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https://www.readbyqxmd.com/read/28110274/c4-photosynthesis-50-years-of-discovery-and-innovation
#1
EDITORIAL
Susanne von Caemmerer, Oula Ghannoum, Robert T Furbank
It is now over half a century since the biochemical characterization of the C4 photosynthetic pathway, and this special issue highlights the sheer breadth of current knowledge. New genomic and transcriptomic information shows that multi-level regulation of gene expression is required for the pathway to function, yet we know it to be one of the most dynamic examples of convergent evolution. Now, a focus on the molecular transition from C3-C4 intermediates, together with improved mathematical models, experimental tools and transformation systems, holds great promise for improving C4 photosynthesis in crops...
January 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28110252/development-of-a-multiphysics-model-to-characterize-the-responsive-behavior-of-urea-sensitive-hydrogel-as-biosensor
#2
K B Goh, Hua Li, K Y Lam
A remarkable feature of biomaterials is their ability to deform in response to certain external bio-stimuli. Here, a novel biochemo-electro-mechanical model is developed for the numerical characterization of the urea-sensitive hydrogel in response to the external stimulus of urea. The urea sensitivity of the hydrogel is usually characterized by the states of ionization and denaturation of the immobilized urease, as such the model includes the effect of the fixed charge groups and temperature coupled with pH on the activity of the urease...
January 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28110067/poly-glycerol-sebacate-elastomer-supports-bone-regeneration-by-its-mechanical-properties-being-closer-to-osteoid-tissue-rather-than-to-mature-bone
#3
S H Zaky, K W Lee, J Gao, A Jensen, K Verdelis, Y Wang, A J Almarza, C Sfeir
: Mechanical load influences bone structure and mass. Arguing the importance of load-transduction, we investigated the mechanisms inducing bone formation using an elastomeric substrate. We characterized Poly (glycerol sebacate) (PGS) in-vitro for its mechanical properties, compatibility with osteoprogenitor cells regarding adhesion, proliferation, differentiation under compression versus static cultures and in-vivo for the regeneration of a rabbit ulna critical size defect. The load-transducing properties of PGS were compared in-vitro to a stiffer poly lactic-co- glycolic-acid (PLA/PGA) scaffold of similar porosity and interconnectivity...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28109891/redox-regulation-of-electrophilic-signaling-by-reactive-persulfides-in-cardiac-cells
#4
REVIEW
Motohiro Nishida, Akiyuki Nishimura, Tetsuro Matsunaga, Hozumi Motohashi, Shingo Kasamatsu, Takaaki Akaike
Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mainly regulated by endogenous electrophiles that are generated from reactive oxygen species, nitric oxide, and the derivative reactive species of nitric oxide during stress responses, as well as by exogenous electrophiles including compounds in foods and environmental pollutants...
January 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28109622/genetics-for-the-identification-of-lipid-targets-beyond-pcsk9
#5
REVIEW
Linda R Wang, Robert A Hegele
From studies of rare families to genome-wide associations in populations, understanding of human genetics has accelerated the search for new drug targets for the prevention of atherosclerotic cardiovascular disease. DNA sequencing and genome-wide analyses of DNA markers have illuminated rare as well as common variants in genes that regulate lipids and ultimately atherosclerosis risk. A recent innovative approach called Mendelian randomization can endorse specific genes and variants as causative not just for lipid disturbances, but also for clinical cardiovascular end points...
November 11, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28109614/onil-stove-innovation-in-the-highlands-of-guatemala
#6
Paul Schultz, Gary Boeke, Stephen Miller, Donald O'Neal
No abstract text is available yet for this article.
January 18, 2017: Surgery
https://www.readbyqxmd.com/read/28109401/melanoma-last-call-for-radiotherapy
#7
REVIEW
Sophie Espenel, Alexis Vallard, Chloé Rancoule, Max-Adrien Garcia, Jean-Baptiste Guy, Cyrus Chargari, Eric Deutsch, Nicolas Magné
Melanoma is traditionally considered to be a radioresistant tumor. However, radiotherapy and immunotherapy latest developments might upset this radiobiological dogma. Stereotactic radiotherapy allows high dose per fraction delivery, with high dose rate. More DNA lethal damages, less sublethal damages reparation, endothelial cell apoptosis, and finally clonogenic cell dysfunction are produced, resulting in improved local control. Radiotherapy can also enhance immune responses, inducing neoantigens formation, tumor antigen presentation, and cytokines release...
February 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28109347/how-is-physician-work-valued
#8
Jeffrey P Jacobs, Stephen J Lahey, Francis C Nichols, James M Levett, George Gilbert Johnston, Richard K Freeman, James D St Louis, Julie Painter, Courtney Yohe, Cameron D Wright, Kirk R Kanter, John E Mayer, Keith S Naunheim, Jeffrey B Rich, Joseph E Bavaria
Strategies to value physician work continue to evolve. The Society of Thoracic Surgeons and The Society of Thoracic Surgeons National Database have an increasingly important role in this evolution. An understanding of the Current Procedural Terminology (CPT) system (American Medical Association [AMA], Chicago, IL) and the Relative Value Scale Update Committee (RUC) is necessary to comprehend how physician work is valued. In 1965, with the dawn of increasingly complex medical care, immense innovation, and the rollout of Medicare, the need for a common language describing medical services and procedures was recognized as being of critical importance...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109341/leadership-and-innovation-listening-to-and-learning-from-young-people-in-burundi
#9
Cédric Nininahazwe, Jacquelyne Alesi, Georgina Caswell, Musah Lumumba, Julie Mellin, Nicholas-Monalisa Ndayizeye, Luisa Orza, Michaela Rahimi, Nienke Westerhof
This commentary describes young people's leadership from the perspective of a youth-led organization in the Link Up project in Burundi, Réseau National des Jeunes vivant avec le VIH. It describes processes that enable young people to guide, influence, deliver, and improve health service provision; the challenges faced by Réseau National des Jeunes vivant avec le VIH and how they are addressing these challenges.
February 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28109266/team-based-care-for-improving-hypertension-management-among-outpatients-tbc-hta-study-protocol-for-a-pragmatic-randomized-controlled-trial
#10
Valérie Santschi, Grégoire Wuerzner, Arnaud Chiolero, Bernard Burnand, Philippe Schaller, Lyne Cloutier, Gilles Paradis, Michel Burnier
BACKGROUND: Blood pressure (BP) is poorly controlled among a large proportion of hypertensive outpatients. Innovative models of care are therefore needed to improve BP control. The Team-Based Care for improving Hypertension management (TBC-HTA) study aims to evaluate the effect of a team-based care (TBC) interprofessional intervention, involving nurses, community pharmacists and physicians, on BP control of hypertensive outpatients compared to usual care in routine clinical practice. METHODS/DESIGN: The TBC-HTA study is a pragmatic randomized controlled study with a 6-month follow-up which tests a TBC interprofessionnal intervention conducted among uncontrolled treated hypertensive outpatients in two ambulatory clinics and among seven nearby community pharmacies in Lausanne and Geneva, Switzerland...
January 21, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28109172/integrated-treatment-options-for-male-perpetrators-of-intimate-partner-violence
#11
Cory A Crane, Caroline J Easton
ISSUES: Male-to-female intimate partner violence remains a worldwide public health issue with adverse physical and psychological consequences for victims, perpetrators and children. Personality disorders, addiction, trauma and mood symptoms are established risk factors for intimate partner violence perpetration and factor prominently into a recovery-oriented treatment approach. APPROACH: We reviewed the partner violence literature for detailed reports of traditional as well as innovative, integrated treatment approaches...
January 21, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28109024/computer-assisted-technologies-used-in-oral-rehabilitation-and-the-clinical-documentation-of-alleged-advantages-a-systematic-review
#12
REVIEW
Asbjørn Jokstad
The objective of this systematic review is to identify current computer-assisted technologies used for managing patients with a need to re-establish craniofacial appearance, subjective discomfort and stomatognathic function, and the extent of their clinical documentation. Electronic search strategies were used for locating clinical studies in MEDLINE through PubMed and in the Cochrane library, and in the grey literature through searches on Google Scholar. The searches for commercial digital products for use in oral rehabilitation resulted in identifying 225 products per November 2016, used for patient diagnostics, communication and therapy purposes, and for other computer-assisted applications in context with oral rehabilitation...
January 21, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28108959/innovative-root-end-filling-materials-based-on-calcium-silicates-and-calcium-phosphates
#13
Ali Abedi-Amin, Arlinda Luzi, Massimo Giovarruscio, Gaetano Paolone, Atanaz Darvizeh, Victoria Vivó Agulló, Salvatore Sauro
This in vitro study evaluated the apical sealing ability, bioactivity and biocompatibility of an experimental calcium silicate-based and two light-curing calcium silicate/calcium-phosphate cements as potential root end filling materials. A calcium silicate Portland-based (Control PC), an experimental calcium silicate (Exp. PC) and two light-curing cements (LC-CaP; LC-Si/CaP) were assessed for their alkalinising activity (pH) and biocompatibility. Single-rooted human canines were endodontically treated, filled with gutta-percha and finally submitted to apicoectomy...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28108887/an-innovative-technology-blueprint-for-medical-education-association-of-directors-of-medical-student-education-in-psychiatry-s-clinical-simulation-initiative-years-1-6
#14
Raed Hawa, Martin Klapheke, Howard Liu, Greg Briscoe, Adriana Foster
No abstract text is available yet for this article.
January 20, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28108774/-hip-dislocation-after-revision-arthroplasty-risk-assessment-and-treatment-strategies
#15
P M Prodinger, J Schauwecker, H Mühlhofer, N Harrasser, F Pohlig, C Suren, R von Eisenhart-Rothe
With a dislocation rate of up to 35% after revision total hip arthroplasty (THA), instability is one of the major causes why this procedure fails. Independent factors for patients at risk are age, sex, and the type of revision needed. The surgical approach, implant choice, and positioning of the components are factors that the surgeon can influence to keep the dislocation rate low. Large femoral heads or double mobility (DM) cups can increase the stability of the joint. After detailed failure analysis, targeted use of different technical innovations enhances stability in revision THA and prevents further revisions...
January 20, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28108747/national-guidelines-for-smoking-cessation-in-primary-care-a-literature-review-and-evidence-analysis
#16
Marjolein Verbiest, Evelyn Brakema, Rianne van der Kleij, Kate Sheals, Georgia Allistone, Siân Williams, Andy McEwen, Niels Chavannes
: National guidelines for smoking cessation in primary care can be effective in improving clinical practice. This study assessed which parties are involved in the development of such guidelines worldwide, which national guidelines address primary care, what recommendations are made for primary care settings, and how these recommendations correlate with each other and with current evidence. We identified national guidelines using an online resource. Only the most recent version of a guideline was included...
December 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28108711/innovation-award-for-sheep-lameness-plan
#17
(no author information available yet)
No abstract text is available yet for this article.
January 21, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28108235/the-use-of-bacteriophages-to-biocontrol-oral-biofilms
#18
Szymon P Szafrański, Andreas Winkel, Meike Stiesch
Infections induced by oral biofilms include caries, as well as periodontal, and peri-implant disease, and may influence quality of life, systemic health, and expenditure. As bacterial biofilms are highly resistant and resilient to conventional antibacterial therapy, it has been difficult to combat these infections. An innovative alternative to the biocontrol of oral biofilms could be to use bacteriophages or phages, the viruses of bacteria, which are specific, non-toxic, self-proliferating, and can penetrate into biofilms...
January 17, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28108189/the-longitudinal-impact-of-an-internet-safety-decision-aid-for-abused-women
#19
Nancy E Glass, Nancy A Perrin, Ginger C Hanson, Tina L Bloom, Jill T Messing, Amber S Clough, Jacquelyn C Campbell, Andrea C Gielen, James Case, Karen B Eden
INTRODUCTION: Women experiencing intimate partner violence (IPV) navigate complex, dangerous decisions. Tailored safety information and safety planning, typically provided by domestic violence service providers, can prevent repeat IPV exposure and associated adverse health outcomes; however, few abused women access these services. The Internet represents a potentially innovative way to connect abused women with tailored safety planning resources and information. The purpose of this study was to compare safety and mental health outcomes at baseline, 6 months, and 12 months among abused women randomized to: (1) a tailored, Internet-based safety decision aid; or (2) control website (typical safety information available online)...
January 17, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28108135/designing-autonomy-opportunities-for-new-wildness-in-the-anthropocene
#20
REVIEW
Bradley Cantrell, Laura J Martin, Erle C Ellis
Maintaining wild places involves increasingly intensive human interventions. Several recent projects use semi-automated mediating technologies to enact conservation and restoration actions, including re-seeding and invasive species eradication. Could a deep-learning system sustain the autonomy of nonhuman ecological processes at designated sites without direct human interventions? We explore here the prospects for automated curation of wild places, as well as the technical and ethical questions that such co-creation poses for ecologists, conservationists, and designers...
January 17, 2017: Trends in Ecology & Evolution
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