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https://www.readbyqxmd.com/read/28426968/map2-defines-a-pre-axonal-filtering-zone-to-regulate-kif1-versus-kif5-dependent-cargo-transport-in-sensory-neurons
#1
Laura F Gumy, Eugene A Katrukha, Ilya Grigoriev, Dick Jaarsma, Lukas C Kapitein, Anna Akhmanova, Casper C Hoogenraad
Polarized cargo transport is essential for neuronal function. However, the minimal basic components required for selective cargo sorting and distribution in neurons remain elusive. We found that in sensory neurons the axon initial segment is largely absent and that microtubule-associated protein 2 (MAP2) defines the cargo-filtering zone in the proximal axon. Here, MAP2 directs axonal cargo entry by coordinating the activities of molecular motors. We show that distinct kinesins differentially regulate cargo velocity: kinesin-3 drives fast axonal cargo trafficking, while kinesin-1 slows down axonal cargo transport...
April 19, 2017: Neuron
https://www.readbyqxmd.com/read/28426954/neuronal-polarity-map2-shifts-secretory-vesicles-into-high-gear-for-long-haul-transport-down-the-axon
#2
Luís F Ribeiro, Joris de Wit
Accurate control of polarized cargo trafficking is essential for neuronal function. In this issue of Neuron, Gumy et al. (2017) show that MAP2 defines a pre-axonal filtering zone and controls axonal cargo transport by influencing the activities of distinct kinesin motors.
April 19, 2017: Neuron
https://www.readbyqxmd.com/read/28426290/development-of-a-thoracic-personal-sampler-system-for-co-sampling-of-sulfuric-acid-mist-and-sulfur-dioxide-gas
#3
Chih-Hsiang Chien, Alexandros Theodore, Chufan Zhou, Chang-Yu Wu, Yu-Mei Hsu, Brian Birky
A novel personal sampler was designed to measure inorganic acid mists and gases for determining human exposure levels to these acids in workplaces. This sampler consists of (1) a parallel impactor for classifying aerosol by size following the ISO/CEN/ACGIH defined human thoracic fraction, (2) a cellulose filter to collect the residual acid mist but allowing penetration of sulfur dioxide gas, and (3) an accordion-shaped porous membrane denuder (aPMD) for adsorbing the penetrating sulfur dioxide gas. Acid-resistant PTFE was chosen as the housing material to minimize sampling interference...
April 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28426205/euro-6-unregulated-pollutant-characterization-and-statistical-analysis-of-aftertreatment-device-and-driving-condition-impact-on-recent-passenger-car-emissions
#4
Simon Martinet, Yao Liu, Cédric Louis, Patrick Tassel, Pascal Perret, Agnès Chaumond, Michel Andre
This study aims to measure and analyze unregulated compound emissions for two Euro 6 diesel and gasoline vehicles. The vehicles were tested on a chassis dynamometer under various driving cycles: Artemis driving cycles (urban, road and motorway), the New European Driving Cycle (NEDC) and the World Harmonized Light-Duty Test Cycle (WLTC) for Europe, and world approval cycles. The emissions of unregulated compounds - such as total particle number (PN) (over 5.6 nm), black carbon (BC), NO2, BTEX (benzene, toluene, ethylbenzene and xylene), carbonyl compounds and polycyclic aromatic hydrocarbons (PAHs) - were measured with several on-line devices and different samples were collected using cartridges and quartz filters...
April 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28425955/homomorphic-filtering-for-improving-time-synchronization-in-wireless-networks
#5
José María Castillo-Secilla, José Manuel Palomares, Fernando León, Joaquín Olivares
Wireless sensor networks are used to sample the environment in a distributed way. Therefore, it is mandatory for all of the measurements to be tightly synchronized in order to guarantee that every sensor is sampling the environment at the exact same instant of time. The synchronization drift gets bigger in environments suffering from temperature variations. Thus, this work is focused on improving time synchronization under deployments with temperature variations. The working hypothesis demonstrated in this work is that the clock skew of two nodes (the ratio of the real frequencies of the oscillators) is composed of a multiplicative combination of two main components: the clock skew due to the variations between the cut of the crystal of each oscillator and the clock skew due to the different temperatures affecting the nodes...
April 20, 2017: Sensors
https://www.readbyqxmd.com/read/28425946/robot-beacon-distributed-range-only-slam-for-resource-constrained-operation
#6
Arturo Torres-González, Jose Ramiro Martínez-de Dios, Anibal Ollero
This work deals with robot-sensor network cooperation where sensor nodes (beacons) are used as landmarks for Range-Only (RO) Simultaneous Localization and Mapping (SLAM). Most existing RO-SLAM techniques consider beacons as passive devices disregarding the sensing, computational and communication capabilities with which they are actually endowed. SLAM is a resource-demanding task. Besides the technological constraints of the robot and beacons, many applications impose further resource consumption limitations...
April 20, 2017: Sensors
https://www.readbyqxmd.com/read/28425394/near-infrared-spectrum-detection-of-wheat-gluten-protein-content-based-on-a-combined-filtering-method
#7
Jian-Hua Cai
To eliminate the random error of the derivative near-IR (NIR) spectrum and to improve model stability and the prediction accuracy of the gluten protein content, a combined method is proposed for pretreatment of the NIR spectrum based on both empirical mode decomposition and the wavelet soft-threshold method. The principle and the steps of the method are introduced and the denoising effect is evaluated. The wheat gluten protein content is calculated based on the denoised spectrum, and the results are compared with those of the nine-point smoothing method and the wavelet soft-threshold method...
April 20, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28424331/filtering-more-than-light-in-the-developing-retina
#8
Maria K Lehtinen
Restricting transcytosis is essential for blood-retinal barrier formation.
April 19, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28423844/identifying-emerging-trends-in-medical-informatics-a-synthesis-approach
#9
Yasmin Van Kasteren, Patricia A H Williams, Anthony Maeder
Medical informatics is a young and rapidly evolving field, influenced by and impacting on many different knowledge domains. Recent contributions on scoping the associated body of knowledge are confounded both by variations in popular use of terminology for established areas, and by the advent of new areas without yet established terminology. Determining the scope of a topic through online bibliographic search filters is a well-established approach in scientific research and has been developed as a human-directed task...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423781/learning-differentially-expressed-gene-pairs-in-microarray-data
#10
Xiao-Lei Xia, Sinead Brophy, Shang-Ming Zhou
To identify differentially expressed genes (DEGs) in analysis of microarray data, a majority of existing filter methods rank gene individually. Such a paradigm could overlook the genes with trivial individual discriminant powers but significant powers of discrimination in their combinations. This paper proposed an impurity metric in which the number of split intervals for each feature is considered as a parameter to be optimized for gaining maximal discrimination. The proposed method was first evaluated by applying to a synthesized noisy rectangular grid dataset, in which the significant feature pair which forms a rectangular grid pattern was successfully recognized...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423775/combining-different-privacy-preserving-record-linkage-methods-for-hospital-admission-data
#11
Jürgen Stausberg, Andreas Waldenburger, Christian Borgs, Rainer Schnell
Record linkage (RL) is the process of identifying pairs of records that correspond to the same entity, for example the same patient. The basic approach assigns to each pair of records a similarity weight, and then determines a certain threshold, above which the two records are considered to be a match. Three different RL methods were applied under privacy-preserving conditions on hospital admission data: deterministic RL (DRL), probabilistic RL (PRL), and Bloom filters. The patient characteristics like names were one-way encrypted (DRL, PRL) or transformed to a cryptographic longterm key (Bloom filters)...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423624/assessment-of-female-breast-dose-for-thoracic-cone-beam-ct-using-mosfet-dosimeters
#12
Wenzhao Sun, Bin Wang, Bo Qiu, Jian Liang, Weihao Xie, Xiaowu Deng, Zhenyu Qi
OBJECTIVE: To assess the breast dose during a routine thoracic cone-beam CT (CBCT) check with the efforts to explore the possible dose reduction strategy. MATERIALS AND METHODS: Metal oxide semiconductor field-effect transistor (MOSFET) dosimeters were used to measure breast surface doses during a thorax kV CBCT scan in an anthropomorphic phantom. Breast doses for different scanning protocols and breast sizes were compared. Dose reduction was attempted by using partial arc CBCT scan with bowtie filter...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423571/predictive-analysis-of-long-non-coding-rna-expression-profiles-in-diffuse-large-b-cell-lymphoma
#13
Danxia Zhu, Cheng Fang, Xiaodong Li, Yiting Geng, Ruiqi Li, Chen Wu, Jingting Jiang, Changping Wu
Long non-coding RNAs (lncRNAs) are implicated in many tumors. To find novel targets for study of diffuse large B-cell lymphoma (DLBCL), our team performed genome-wide analyses of lncRNA expression in 5 DLBCL cell lines using the 4*180K Agilent lncRNA Chip system, and in normal B cells. Five lncRNAs were validated by quantitative reverse transcription polymerase chain reaction. The differentially expressed lncRNAs and mRNAs were identified via false discovery rate and fold-change filtering. Potential targets correlated with DLBCL were recognized via gene ontology and pathway analysis...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422922/the-spatial-epidemiology-of-pediatric-trauma-a-statewide-assessment
#14
Allison Ertl, Kirsten Beyer, Sergey Tarima, Yuhong Zhou, Jonathan I Groner, Laura D Cassidy
INTRODUCTION: Despite significant advances in the prevention and treatment of pediatric trauma, preventable injuries continue to burden the lives of millions of children. In order to target prevention strategies, it is critical to identify areas with high burdens of pediatric trauma. Therefore, this study analyzed statewide data from the Ohio Trauma Registry (OTR) from 2007-2012 to identify geographical patterns in pediatric injury. METHODS: Data from the first hospital of care for 16,330 pediatric trauma patients under 16 years old were analyzed using the disease mapping method adaptive spatial filtering to estimate a series of maps that display age- and sex-adjusted rates of pediatric trauma, severe trauma, and standardized mortality ratios (SMR) while controlling for population size to create stable estimates throughout the study area...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28422703/differential-hemoglobin-a-sequestration-between-hemodialysis-modalities
#15
Uzma Naseeb, Shamshad Zarina, Theres Jägerbrink, Jawed Shafqat, Hans Jörnvall, Jonas Axelsson
This report evaluates plasma protein patterns, dialysates and protein analysis of used dialysis membranes from the same patient under hemodialysis in three separate modalities, using high-flux membranes in concentration-driven transport (HD), convection-driven hemofiltration (HF) and combined hemodialfiltration (HDF). The plasma protein changes induced by each of the three dialysis modalities showed small differences in proteins identified towards our previous plasma analyses of chronic kidney disease (CKD) patients...
April 19, 2017: Biomolecular Concepts
https://www.readbyqxmd.com/read/28422698/dissipativity-based-resilient-filtering-of-periodic-markovian-jump-neural-networks-with-quantized-measurements
#16
Renquan Lu, Jie Tao, Peng Shi, Hongye Su, Zheng-Guang Wu, Yong Xu
The problem of dissipativity-based resilient filtering for discrete-time periodic Markov jump neural networks in the presence of quantized measurements is investigated in this paper. Due to the limited capacities of network medium, a logarithmic quantizer is applied to the underlying systems. Considering the fact that the filter is realized through a network, randomly occurring parameter uncertainties of the filter are modeled by two mode-dependent Bernoulli processes. By establishing the mode-dependent periodic Lyapunov function, sufficient conditions are given to ensure the stability and dissipativity of the filtering error system...
April 12, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28422697/manifold-regularized-correlation-object-tracking
#17
Hongwei Hu, Bo Ma, Jianbing Shen, Ling Shao
In this paper, we propose a manifold regularized correlation tracking method with augmented samples. To make better use of the unlabeled data and the manifold structure of the sample space, a manifold regularization-based correlation filter is introduced, which aims to assign similar labels to neighbor samples. Meanwhile, the regression model is learned by exploiting the block-circulant structure of matrices resulting from the augmented translated samples over multiple base samples cropped from both target and nontarget regions...
April 12, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28422682/mri-based-medial-axis-extraction-and-boundary-segmentation-of-cranial-nerves-through-discrete-deformable-3d-contour-and-surface-models
#18
Sharmin Sultana, Jason Blatt, Benjamin Gilles, Tanweer Rashid, Michel Audette
This paper presents a segmentation technique to identify the medial axis and the boundary of cranial nerves. We utilize a 3D deformable 1-simplex discrete contour model to ex-tract the medial axis of each cranial nerve. This contour model represents a collection of 2-connected vertices linked by edges, where vertex position is determined by a Newtonian expression for vertex kinematics featuring internal and external forces, the latter of which include attractive forces towards the nerve medial axis. We exploit multiscale vesselness filtering and minimal path techniques in the medial axis extraction method, which also com-putes a radius estimate along the path...
April 12, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28422681/fast-median-filtering-for-phase-or-orientation-data
#19
Martin Storath, Andreas Weinmann
Median filtering is among the most utilized tools for smoothing real-valued data, as it is robust, edge-preserving, valuepreserving, and yet can be computed efficiently. For data living on the unit circle, such as phase data or orientation data, a filter with similar properties is desirable. For these data, there is no unique means to define a median; so we discuss various possibilities. The arc distance median turns out to be the only variant which leads to robust, edge-preserving and value-preserving smoothing...
April 12, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28422678/correlation-filter-learning-toward-peak-strength-for-visual-tracking
#20
Yao Sui, Guanghui Wang, Li Zhang
This paper presents a novel visual tracking approach to correlation filter learning toward peak strength of correlation response. Previous methods leverage all features of the target and the immediate background to learn a correlation filter. Some features, however, may be distractive to tracking, like those from occlusion and local deformation, resulting in unstable tracking performance. This paper aims at solving this issue and proposes a novel algorithm to learn the correlation filter. The proposed approach, by imposing an elastic net constraint on the filter, can adaptively eliminate those distractive features in the correlation filtering...
April 13, 2017: IEEE Transactions on Cybernetics
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