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https://www.readbyqxmd.com/read/28346467/characterization-and-interstrain-transfer-of-prophage-pp3-of-pseudomonas-aeruginosa
#1
Gang Li, Shuguang Lu, Mengyu Shen, Shuai Le, Wei Shen, Yinling Tan, Jing Wang, Xia Zhao, Yan Zhao, Yali Gong, Yuhui Yang, Hongbin Zhu, Fuquan Hu, Ming Li
Prophages are major contributors to horizontal gene transfer and drive the evolution and diversification of bacteria. Here, we describe the characterization of a prophage element designated pp3 in the clinical Pseudomonas aeruginosa isolate PA1. pp3 spontaneously excises from the PA1 genome and circularizes at a very high frequency of 25%. pp3 is likely to be a defective prophage due to its inability to form plaques on P. aeruginosa indicator strains, and no phage particles could be detected in PA1 supernatants...
2017: PloS One
https://www.readbyqxmd.com/read/28346350/fast-and-selective-plasmonic-serotonin-detection-with-aptamer-gold-nanoparticle-conjugates
#2
Jorge L Chávez, Joshua A Hagen, Nancy Kelley-Loughnane
Neurotransmitters detection is critical to understanding communication between the brain and peripheral tissue. Serotonin is a key neurotransmitter linked to a number of conditions, but a full understanding of its role in disease is still lacking. The development of fast and selective serotonin detection platforms will provide researchers with tools to monitor serotonin in individuals before and after treatment for the condition of interest. Aptamer-gold nanoparticles conjugates that responded colorimetrically to serotonin with minimal response to its metabolite and other neurotransmitters were designed by simply adsorbing the DNA on the surface of AuNPs...
March 25, 2017: Sensors
https://www.readbyqxmd.com/read/28346346/an-effective-terrain-aided-navigation-for-low-cost-autonomous-underwater-vehicles
#3
Ling Zhou, Xianghong Cheng, Yixian Zhu, Chenxi Dai, Jinbo Fu
Terrain-aided navigation is a potentially powerful solution for obtaining submerged position fixes for autonomous underwater vehicles. The application of terrain-aided navigation with high-accuracy inertial navigation systems has demonstrated meter-level navigation accuracy in sea trials. However, available sensors may be limited depending on the type of the mission. Such limitations, especially for low-grade navigation sensors, not only degrade the accuracy of traditional navigation systems, but further impact the ability to successfully employ terrain-aided navigation...
March 25, 2017: Sensors
https://www.readbyqxmd.com/read/28346338/smartfluo-a-method-and-affordable-adapter-to-measure-chlorophyll-a-fluorescence-with-smartphones
#4
Anna Friedrichs, Julia Anke Busch, Hendrik Jan van der Woerd, Oliver Zielinski
In order to increase the monitoring capabilities of inland and coastal waters, there is a need for new, affordable, sensitive and mobile instruments that could be operated semi-automatically in the field. This paper presents a prototype device to measure chlorophyll a fluorescence: the SmartFluo. The device is a combination of a smartphone offering an intuitive operation interface and an adapter implying a cuvette holder, as well as a suitable illumination source. SmartFluo is based on stimulated fluorescence of water constituents such as chlorophyll a...
March 25, 2017: Sensors
https://www.readbyqxmd.com/read/28346098/filter-plate-based-screening-of-mip-spe-materials-for-capture-of-the-biomarker-pro-gastrin-releasing-peptide
#5
Kishore Kumar Jagadeesan, Cecilia Rossetti, Abed Abdel Qader, Léon Reubsaet, Börje Sellergren, Thomas Laurell, Simon Ekström
Affinity-based solid-phase extraction (SPE) is an attractive low-cost sample preparation strategy for biomarker analysis. Molecularly imprinted polymers (MIPs) as affinity sorbents offer unique opportunities for affinity SPE, due to their low manufacturing cost and high robustness. A limitation is the prediction of their affinity; therefore, screening of analyte recovery and specificity within a large range of SPE conditions is important in order to ensure high-sensitivity detection and assay reproducibility...
January 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28346089/a-chemogenomic-screening-platform-used-to-identify-chemotypes-perturbing-hsp90-pathways
#6
Fiona M Thomas, Kourtney M Goode, Bartek Rajwa, Andrew B Bieberich, Larisa V Avramova, Tony R Hazbun, V Jo Davisson
Compounds that modulate the heat shock protein (HSP) network have potential in a broad range of research applications and diseases. A yeast-based liquid culture assay that measured time-dependent turbidity enabled the high-throughput screening of different Saccharomyces cerevisae strains to identify HSP modulators with unique molecular mechanisms. A focused set of four strains, with differing sensitivities to Hsp90 inhibitors, was used to screen a compound library of 3680 compounds. Computed turbidity curve functions were used to classify strain responses and sensitivity to chemical effects across the compound library...
January 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28346014/intestinal-absorption-and-renal-reabsorption-of-calcium-throughout-postnatal-development
#7
Megan R Beggs, R Todd Alexander
Calcium is vital for many physiological functions including bone mineralization. Postnatal deposition of calcium into bone is greatest in infancy and continues through childhood and adolescence until peek mineral density is reached in early adulthood. Thereafter, bone mineral density remains static until it eventually declines in later life. A positive calcium balance, i.e. more calcium absorbed than excreted, is crucial to bone deposition during growth and thus to peek bone mineral density. Dietary calcium is absorbed from the intestine into the blood...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28345932/formation-of-turmeric-based-thin-films-universal-and-transparent-coating
#8
Do Kyoung Yeon, So Hyun Ki, Jeanne Choi, Sung Min Kang, Woo Kyung Cho
Curry stains on clothes and dishes in daily life inspired us to investigate the potential use of a turmeric powder, major ingredient of curry, as a universal-coating material. After condition optimization, the coating solution was made by boiling and filtering a turmeric slurry, and the coating was performed at pH 3, leading to the formation of ultrathin and transparent films. Various inorganic and polymeric substrates were successfully coated with turmeric-based materials, including gold, TiO2, SiO2, glass, stainless steel, indium tin oxide, nylon, polyethylene, polycarbonate, polypropylene, acryl, and polyethylene terephthalate...
March 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28345760/effect-of-temperature-on-lysosomal-enzyme-activity-during-preparation-and-storage-of-dried-blood-spots
#9
Manjunath Supriya, Tanima De, Rita Christopher
BACKGROUND: The use of dried blood spots (DBS) for the assay of lysosomal enzymes has facilitated the implementation of pilot studies for newborn screening for lysosomal storage disorders in various developed countries. The aim of the study was to determine the influence of ambient temperature during DBS preparation and storage on lysosomal enzyme activity in a developing, tropical country. METHODS: Blood samples from 12 healthy subjects collected on a S&S 903 filter paper were dried and stored at different temperatures for different periods of time...
March 27, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28345700/electronic-structure-and-magnetic-properties-of-penta-graphene-nanoribbons
#10
P F Yuan, Z H Zhang, Z Q Fan, M Qiu
2D penta-graphene sheets were cut along typical crystallographic orientations in order to construct various penta-graphene nanoribbon (P-GNR) models, and their electronic structures and magnetic properties were systemically investigated. It was demonstrated that P-GNRs are very versatile with rich and unique electronic and magnetic properties. In particular, bipolar magnetic semiconducting features can be achieved in the ferromagnetic state for all magnetic P-GNRs, which makes P-GNRs valuable for developing next-generation information storage devices...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28345583/synergistic-effects-of-micro-electrolysis-photocatalysis-on-water-treatment-and-fish-performance-in-saline-recirculating-aquaculture-system
#11
Zhangying Ye, Shuo Wang, Weishan Gao, Haijun Li, Luowei Pei, Mingwei Shen, Songming Zhu
A new physico-chemical process for TAN (total ammonia nitrogen) removal and disinfection is introduced in saline recirculating aquaculture system (RAS), in which the biofilter is replaced with an integrated electrolysis cell and an activated carbon filter. The electrolysis cell which is based on micro current electrolysis combined with UV-light was self-designed. After the fundamental research, a small pilot scale RAS was operated for 30 days to verify the technical feasibility. The system was stocked by 42 GIFT tilapia (Oreochromis niloticus) fish with the rearing density of 13 kg/m(3)...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345564/innovations-in-glaucoma-surgery-from-dr-rajendra-prasad-centre-for-ophthalmic-sciences
#12
Tanuj Dada, Neha Midha, Pooja Shah, Talvir Sidhu, Dewang Angmo, Ramanjit Sihota
Trabeculectomy surgery is the current standard of care in glaucoma for achieving a low target intraocular pressure if medical therapy is not adequate. Augmentation of trabeculectomy with antimetabolites brought a revolutionary change in the long-term success rates of trabeculectomy, but along with it came a plethora of complications. There still is a big window for therapeutic innovations on this subject. The foremost target for these innovations is to modulate the wound healing response after glaucoma drainage surgery...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28345547/contrast-dose-and-radiation-dose-reduction-in-abdominal-enhanced-computerized-tomography-scans-with-single-phase-dual-energy-spectral-computerized-tomography-mode-for-children-with-solid-tumors
#13
Tong Yu, Jun Gao, Zhi-Min Liu, Qi-Feng Zhang, Yong Liu, Ling Jiang, Yun Peng
BACKGROUND: Contrast dose and radiation dose reduction in computerized tomography (CT) scan for adult has been explored successfully, but there have been few studies on the application of low-concentration contrast in pediatric abdominal CT examinations. This was a feasibility study on the use of dual-energy spectral imaging and adaptive statistical iterative reconstruction (ASiR) for the reduction of radiation dose and iodine contrast dose in pediatric abdominal CT patients with solid tumors...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28345368/sponsors-and-investigative-staffs-perceptions-of-the-current-investigational-new-drug-safety-reporting-process-in-oncology-trials
#14
Raymond Perez, Patrick Archdeacon, Nancy Roach, Robert Goodwin, Jonathan Jarow, Nina Stuccio, Annemarie Forrest
BACKGROUND/AIMS: The Food and Drug Administration's final rule on investigational new drug application safety reporting, effective from 28 March 2011, clarified the reporting requirements for serious and unexpected suspected adverse reactions occurring in clinical trials. The Clinical Trials Transformation Initiative released recommendations in 2013 to assist implementation of the final rule; however, anecdotal reports and data from a Food and Drug Administration audit indicated that a majority of reports being submitted were still uninformative and did not result in actionable changes...
March 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28345344/unravelling-and-quantifying-the-nmr-invisible-metabolites-interacting-with-human-serum-albumin-by-binding-competition-and-t2-relaxation-based-decomposition-analysis
#15
Ruben Barrilero, Noelia Ramirez, Joan Carles Vallvé, Delia Taverner, Rocío Fuertes, Núria Amigó, Xavier Correig
Quantitative profiling of low-molecular-weight metabolites (LMWM) by 1H-NMR is routinely used in high-throughput serum metabolomics. First, the protein background is attenuated using a T2 filter, then the LMWM signals are resolved by line-shape fitting. However, protein binding modifies the motional properties of LMWM and their signal partially attenuates with the T2 filter, along with the protein background. Consequently, the quantified LMWM signal does not reflect the total concentration in serum but the non-binding part...
March 27, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28344725/sensitive-and-predictable-separation-of-microfluidic-droplets-by-size-using-in-line-passive-filter
#16
Ruihua Ding, W Lloyd Ung, John A Heyman, David A Weitz
Active manipulation of droplets is crucial in droplet microfluidics. However, droplet polydispersity decreases the accuracy of active manipulation. We develop a microfluidic "droplet filter" that accurately separates droplets by size. The droplet filter has a sharp size cutoff and is capable of distinguishing droplets differing in volume by 20%. A simple model explains the behavior of the droplets as they pass through the filter. We show application of the filter in improving dielectric sorting efficiency.
January 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28344618/patient-and-lesion-tailored-algorithm-of-endovascular-treatment-for-arterial-occlusive-disease-of-extracranial-arteries-supplying-the-brain-safety-of-the-treatment-at-30-day-follow-up
#17
Paweł Latacz, Marian Simka, Paweł Brzegowy, Piotr Janas, Marek Kazibudzki, Piotr Pieniążek, Andrzej Ochała, Tadeusz Popiela, Tomasz Mrowiecki
INTRODUCTION: Although surgical endarterectomy remains the treatment of choice for carotid artery stenosis, stenting plays an important role as an alternative treatment modality, especially in high-risk patients. The actual safety profile associated with stenting procedures is probably better than that reported by randomized controlled trials. AIM: To assess the safety of stent implantations in extracranial arteries supplying the brain, and also to identify risk factors associated with this procedure...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28343986/the-hemodynamic-signal-as-a-first-order-low-pass-temporal-filter-evidence-and-implications-for-neuroimaging-studies
#18
Antoine Sauvage, Guillaume Hubert, Jonathan Touboul, Jérôme Ribot
Neuronal activation triggers local changes in blood flow and hemoglobin oxygenation. These hemodynamic signals can be recorded through functional magnetic resonance imaging or intrinsic optical imaging, and allows inferring neural activity in response to stimuli. These techniques are widely used to uncover functional brain architectures. However, their accuracy suffers from distortions inherent to hemodynamic responses and noise. The analysis of these signals currently relies on models of impulse hemodynamic responses to brief stimuli...
March 23, 2017: NeuroImage
https://www.readbyqxmd.com/read/28343964/the-temporal-tuning-of-the-drosophila-motion-detectors-is-determined-by-the-dynamics-of-their-input-elements
#19
Alexander Arenz, Michael S Drews, Florian G Richter, Georg Ammer, Alexander Borst
Detecting the direction of motion contained in the visual scene is crucial for many behaviors. However, because single photoreceptors only signal local luminance changes, motion detection requires a comparison of signals from neighboring photoreceptors across time in downstream neuronal circuits. For signals to coincide on readout neurons that thus become motion and direction selective, different input lines need to be delayed with respect to each other. Classical models of motion detection rely on non-linear interactions between two inputs after different temporal filtering...
March 18, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28343934/hitchhiker-s-guide-to-the-red-cell-storage-galaxy-omics-technologies-and-the-quality-issue
#20
REVIEW
Angelo D'Alessandro, Jerard Seghatchian
Red blood cell storage in the blood bank makes millions of units of available for transfusion to civilian and military recipients every year. From glass bottles to plastic bags, from anticoagulants to complex additives, from whole blood to leukocyte filtered packed red blood cells: huge strides have been made in the field of blood component processing and storage in the blood bank during the last century. Still, refrigerated preservation of packed red blood cells under blood bank conditions results in the progressive accumulation of a wide series of biochemical and morphological changes to the stored erythrocytes, collectively referred to as the storage lesion(s)...
March 9, 2017: Transfusion and Apheresis Science
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