Emma Carrothers, Meghan Appleby, Vita Lai, Tatiana Kozbenko, Dalya Alomar, Benjamin J Smith, Nobuyuki Hamada, Patricia Hinton, Elizabeth A Ainsbury, Robyn Hocking, Carole Yauk, Ruth C Wilkins, Vinita Chauhan
Cataracts are one of the leading causes of blindness, with an estimated 95 million people affected worldwide. A hallmark of cataract development is lens opacification, typically associated not only with aging but also radiation exposure as encountered by interventional radiologists and astronauts during the long-term space mission. To better understand radiation-induced cataracts, the adverse outcome pathway (AOP) framework was used to structure and evaluate knowledge across biological levels of organization (e...
April 21, 2024: Environmental and Molecular Mutagenesis