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https://www.readbyqxmd.com/read/28110410/neurophysiological-assessment-of-brain-dysfunction-in-critically-ill-patients-an-update
#1
REVIEW
Eric Azabou, Catherine Fischer, Jean Michel Guerit, Djillali Annane, François Mauguiere, Fréderic Lofaso, Tarek Sharshar
The aim of this review was to provide up-to-date information about the usefulness of clinical neurophysiology testing in the management of critically ill patients. Evoked potentials (EPs) and electroencephalogram (EEG) are non-invasive clinical neurophysiology tools that allow an objective assessment of the central nervous system's function at the bedside in intensive care unit (ICU). These tests are quite useful in diagnosing cerebral complications, and establishing the vital and functional prognosis in ICU...
January 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28110208/inflammatory-pathway-genes-associated-with-inter-individual-variability-in-the-trajectories-of-morning-and-evening-fatigue-in-patients-receiving-chemotherapy
#2
Fay Wright, Marilyn Hammer, Steven M Paul, Bradley E Aouizerat, Kord M Kober, Yvette P Conley, Bruce A Cooper, Laura B Dunn, Jon D Levine, Gail DEramo Melkus, Christine Miaskowski
Fatigue, a highly prevalent and distressing symptom during chemotherapy (CTX), demonstrates diurnal and interindividual variability in severity. Little is known about the associations between variations in genes involved in inflammatory processes and morning and evening fatigue severity during CTX. The purposes of this study, in a sample of oncology patients (N=543) with breast, gastrointestinal (GI), gynecological (GYN), or lung cancer who received two cycles of CTX, were to determine whether variations in genes involved in inflammatory processes were associated with inter-individual variability in initial levels as well as in the trajectories of morning and evening fatigue...
January 19, 2017: Cytokine
https://www.readbyqxmd.com/read/28110196/application-of-modern-anticoincidence-ac-system-in-hpge-%C3%AE-spectrometry-for-the-detection-limit-lowering-of-the-radionuclides-in-air-filters
#3
Magdalena Długosz-Lisiecka
The use of active and passive shields can substantially reduce the Minimum Detectable Activity (MDA) of the γ-ray counting systems, rejecting events induced by cosmic-rays or by environmental radioactivity. However, the size and geometry of the samples lead to limitations in the background reduction in routine measurements. The Minimum Detectable Activity (MDA) values for low energy of γ-ray emitting radionuclides (<200 keV) deposited in three typical air filter geometries have been compared for anticoincidence and single HPGe detector mode of γ-spectrometry systems...
January 19, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28110015/rapid-assessment-of-estrogenic-compounds-by-cxcl-test-illustrated-by-the-screening-of-the-uv-filter-derivative-benzophenones
#4
Denis Habauzit, Catherine Martin, Gwenneg Kerdivel, Farzad Pakdel
CXCL-test is a method that uses the estrogen-dependent secretion of the natural endogenous chemokine CXCL12 to evaluate the estrogenic activity of molecules. CXCL12 chemokine is involved in the estrogen dependent proliferation of breast cancer cells. Its measure is an indicator of cell proliferation and is used as an alternative test to classical proliferation test. Here we aimed to optimize this test, first to increase the number of tested molecules in a single assay and then to decrease the number of intermediate steps...
January 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28109919/the-ozone-like-syndrome-in-durum-wheat-triticum-durum-desf-mechanisms-underlying-the-different-symptomatic-responses-of-two-sensitive-cultivars
#5
Valentina Picchi, Robert Monga, Riccardo Marzuoli, Giacomo Gerosa, Franco Faoro
Colombo and Sculptur are two modern durum wheat cultivars that, in previous studies, proved to be very sensitive to ozone injury in terms of eco-physiological parameters and significant grain yield loss. Nevertheless, their response regarding leaf visible symptoms was very different; Sculptur showed almost no symptoms, even after several weeks of ozone exposure, whereas Colombo showed in a few weeks typical ozone-like symptoms (chlorotic/necrotic spots). The mechanisms underlying this different response has been studied with a biochemical and microscopical approach...
January 12, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28109880/dynamics-of-the-eag1-k-channel-selectivity-filter-assessed-by-molecular-dynamics-simulations
#6
Harald Bernsteiner, Michael Bründl, Anna Stary-Weinzinger
EAG1 channels belong to the KCNH family of voltage gated potassium channels. They are expressed in several brain regions and increased expression is linked to certain cancer types. Recent cryo-EM structure determination finally revealed the structure of these channels in atomic detail, allowing computational investigations. In this study, we performed molecular dynamics simulations to investigate the ion binding sites and the dynamical behavior of the selectivity filter. Our simulations suggest that sites S2 and S4 form stable ion binding sites, while ions placed at sites S1 and S3 rapidly switched to sites S2 and S4...
January 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28109742/development-of-a-new-uplc-esi-ms-ms-method-for-the-determination-of-biopterin-and-neopterin-in-dried-blood-spot
#7
Silvia Santagata, Emanuele Di Carlo, Carla Carducci, Vincenzo Leuzzi, Antonio Angeloni, Claudia Carducci
BACKGROUND: (6R)-5,6,7,8-tetrahydrobiopterin (BH4) deficiencies are rare inherited defects of synthesis or regeneration of BH4. Due to the resulting hyperphenylalaninemia (HPA), some of them are detectedby newborn screening and require the assessment of the pattern of neopterin (Neo) and biopterin (Bio) excretion in urine to be confirmed. Aim of presentstudy was to develop a method for the measurement of these diagnostic biomarkers in dried blood spot (DBS). METHODS: After DBS extraction, samples were filtered and injected into the UPLC column coupled with atandem mass spectrometer working in positive electrospray ionization...
January 18, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28109666/diminished-auditory-sensory-gating-during-active-auditory-verbal-hallucinations
#8
Robert J Thoma, Andrew Meier, Jon Houck, Vincent P Clark, Jeffrey D Lewine, Jessica Turner, Vince Calhoun, Julia Stephen
Auditory sensory gating, assessed in a paired-click paradigm, indicates the extent to which incoming stimuli are filtered, or "gated", in auditory cortex. Gating is typically computed as the ratio of the peak amplitude of the event related potential (ERP) to a second click (S2) divided by the peak amplitude of the ERP to a first click (S1). Higher gating ratios are purportedly indicative of incomplete suppression of S2 and considered to represent sensory processing dysfunction. In schizophrenia, hallucination severity is positively correlated with gating ratios, and it was hypothesized that a failure of sensory control processes early in auditory sensation (gating) may represent a larger system failure within the auditory data stream; resulting in auditory verbal hallucinations (AVH)...
January 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28109427/filter-aided-sample-preparation-the-versatile-and-efficient-method-for-proteomic-analysis
#9
J R Wiśniewski
Filter-aided sample preparation (FASP) is a versatile and efficient way of processing protein extracts for bottom-up proteomic analysis. The method repurposes centrifugal ultrafiltration concentrators for removal of detergents, protein cleavage, and isolation of pure peptide fractions. FASP can be used for protein cleavage with different proteinases either with single enzymes or in a mode of successive multienzyme digestion (MED)-FASP. The FASP methods are useful for processing of samples ranging in their sizes from submicrogram to several milligram amounts of total protein...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28108758/composition-of-gut-microbiota-in-the-gibel-carp-carassius-auratus-gibelio-varies-with-host-development
#10
Xinghao Li, Li Zhou, Yuhe Yu, Jiajia Ni, Wenjie Xu, Qingyun Yan
To understand how a bacteria-free fish gut ecosystem develops microbiota as the fish ages, we performed a 1-year study on the gut microbiota of hatchling gibel carp (Carassius auratus gibelio). Our results indicate that the gut microbial diversity increases significantly as the fish develop. The gut microbial community composition showed significant shifts corresponding to host age and appeared to shift at two time points despite consistent diet and environmental conditions, suggesting that some features of the gut microbial community may be determined by the host's development...
January 20, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28108380/the-taste-of-heat-how-humoral-qualities-act-as-a-cultural-filter-for-chemosensory-properties-guiding-herbal-medicine
#11
Matthias S Geck, Stefano Cabras, Laura Casu, Alberto J Reyes García, Marco Leonti
ETHNOPHARMACOLOGICAL RELEVANCE: Organoleptic properties, and more specifically chemosensory cues, have been shown to guide therapeutic applications of medicinal plants. Humoral qualities, on the other hand, are widely believed to be an abstract concept, mainly applied post hoc to validate therapy. However, the nexus between humoral qualities, chemosensory properties, and medicinal plant uses has never been systematically assessed. AIM OF THE STUDY: To systematically analyse the correlations between chemosensory properties, humoral qualities, and medicinal uses of selected botanical drugs...
January 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28108092/the-analysis-and-application-of-a-new-hybrid-pollutants-forecasting-model-using-modified-kolmogorov-zurbenko-filter
#12
Peizhi Li, Yong Wang, Qingli Dong
Cities in China suffer from severe smog and haze, and a forecasting system with high accuracy is of great importance to foresee the concentrations of the airborne particles. Compared with chemical transport models, the growing artificial intelligence models can simulate nonlinearities and interactive relationships and getting more accurate results. In this paper, the Kolmogorov-Zurbenko (KZ) filter is modified and firstly applied to construct the model using an artificial intelligence method. The concentration of inhalable particles and fine particulate matter in Dalian are used to analyze the filtered components and test the forecasting accuracy...
January 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28107976/sensitive-fluorescent-detection-of-h2o2-and-glucose-in-human-serum-based-on-inner-filter-effect-of-squaric-acid-iron-iii-on-the-fluorescence-of-upconversion-nanoparticle
#13
Hongyu Chen, Aijin Fang, Li He, Youyu Zhang, Shouzhuo Yao
Diabetes mellitus is an epidemic disease that it has became a worldwide public health problem. Thus, blood glucose monitoring has attracted extensive attention. Here, we report a nanosensor based on inner filter effect (IFE) between upconversion nanoparticles (UCNPs) and squaric acid (SQA)-iron(III) for the highly sensitive and selective detection of glucose levels in human serum. In this assay, GOx-catalyzed oxidization of glucose produces gluconic acid and hydrogen peroxide (H2O2). The latter can catalytically oxidize iron(II) to iron(III) which can rapidly (<1min) coordinate with the SQA to produce (SQA)-iron(III)...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107902/electrolyzing-synthesis-of-boron-doped-graphene-quantum-dots-for-fluorescence-determination-of-fe-3-ions-in-water-samples
#14
Li Chen, Chuanli Wu, Pan Du, Xiaowei Feng, Ping Wu, Chenxin Cai
This work reports a facile electrolyzing method to synthesize boron-doped graphene quantum dots (BGQDs) and uses the BGQDs as a fluorescent probe to determine Fe(3+) ion levels in water samples. The BGQDs were produced by oxidizing graphite in an aqueous borax solution at pH 7; then, the borate solution was filtered with BGQDs, and the borate was dialyzed from the filtrate, leaving a solution of BGQDs in water. The amount of the B in the BGQDs can be adjusted by changing the concentration of borax used for the electrolyte...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107832/a-simple-method-to-produce-2d-and-3d-microfluidic-paper-based-analytical-devices-for-clinical-analysis
#15
Ricardo A G de Oliveira, Fiamma Camargo, Naira C Pesquero, Ronaldo Censi Faria
This paper describes the fabrication of 2D and 3D microfluidic paper-based analytical devices (μPADs) for monitoring glucose, total protein, and nitrite in blood serum and artificial urine. A new method of cutting and sealing filter paper to construct μPADs was demonstrated. Using an inexpensive home cutter printer soft cellulose-based filter paper was easily and precisely cut to produce pattern hydrophilic microchannels. 2D and 3D μPADs were designed with three detection zones each for the colorimetric detection of the analytes...
March 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28107542/temporal-segregation-between-dung-inhabiting-beetle-and-fly-species
#16
Frantisek Xaver Jiri Sladecek, Simon Tristram Segar, Colin Lee, Richard Wall, Martin Konvicka
The coexistence of ecologically similar species (i.e. species utilizing the same resource) is a major topic in ecology. Communities are assembled either through the biotic interactions of ecologically similar species, e.g. competition, or by the abiotic separation of species along gradients of environmental conditions. Here, we investigated the temporal segregation, succession and seasonality of dung-inhabiting Coleoptera and Diptera that utilize an identical resource in exactly the same way. The data were collected from two temperate pastures, one in the United Kingdom and the second in the Czech Republic...
2017: PloS One
https://www.readbyqxmd.com/read/28107309/-delay-to-operating-room-fails-to-identify-adverse-outcomes-at-a-level-i-trauma-center
#17
Paul R Lewis, Jayraan Badiee, Michael J Sise, Richard Y Calvo, Jason B Brill, James D Wallace, Steven R Shackford, Casey E Dunne, Vishal Bansal, C Beth Sise
BACKGROUND: The American College of Surgeons Committee on Trauma devised process audit filters to identify opportunities for improvement (OFI), prevent adverse outcomes, and improve quality. Delay to the operating room for primary trauma laparotomy is a process audit filter that has not been definitively associated with improved outcomes. We sought to evaluate the effectiveness of delay to the operating room of greater than 2 hours (DOR) to independently identify an adverse outcome or an OFI at our Level I trauma center...
February 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28106813/transcriptome-profiling-of-the-lungs-reveals-molecular-clock-genes-expression-changes-after-chronic-exposure-to-ambient-air-particles
#18
Pengcheng Song, Zhigang Li, Xiaoqian Li, Lixin Yang, Lulu Zhang, Nannan Li, Chen Guo, Shuyu Lu, Yongjie Wei
The symptoms of asthma, breathlessness, insomnia, etc. all have relevance to pulmonary rhythmic disturbances. Epidemiology and toxicology studies have demonstrated that exposure to ambient air particles can result in pulmonary dysfunction. However, there are no data directly supporting a link between air pollution and circadian rhythm disorder. In the present study, we found that breathing highly polluted air resulted in changes of the molecular clock genes expression in lung by transcriptome profiling analyses in a rodent model...
January 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28106748/two-dimensional-numerical-simulations-of-ultrasound-in-liquids-with-gas-bubble-agglomerates-examples-of-bubbly-liquid-type-acoustic-metamaterials-blamms
#19
Christian Vanhille
This work deals with a theoretical analysis about the possibility of using linear and nonlinear acoustic properties to modify ultrasound by adding gas bubbles of determined sizes in a liquid. We use a two-dimensional numerical model to evaluate the effect that one and several monodisperse bubble populations confined in restricted areas of a liquid have on ultrasound by calculating their nonlinear interaction. The filtering of an input ultrasonic pulse performed by a net of bubbly-liquid cells is analyzed. The generation of a low-frequency component from a single cell impinged by a two-frequency harmonic wave is also studied...
January 17, 2017: Sensors
https://www.readbyqxmd.com/read/28106716/tracking-and-classification-of-in-air-hand-gesture-based-on-thermal-guided-joint-filter
#20
Seongwan Kim, Yuseok Ban, Sangyoun Lee
The research on hand gestures has attracted many image processing-related studies, as it intuitively conveys the intention of a human as it pertains to motional meaning. Various sensors have been used to exploit the advantages of different modalities for the extraction of important information conveyed by the hand gesture of a user. Although many works have focused on learning the benefits of thermal information from thermal cameras, most have focused on face recognition or human body detection, rather than hand gesture recognition...
January 17, 2017: Sensors
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