keyword
MENU ▼
Read by QxMD icon Read
search

filter

keyword
https://www.readbyqxmd.com/read/28637216/qualitative-analysis-and-detection-of-the-pyrolytic-products-of-jwh-018-and-11-additional-synthetic-cannabinoids-in-the-presence-of-common-herbal-smoking-substrates
#1
Stephen Raso, Suzanne Bell
Synthetic cannabinoids have become a ubiquitous challenge in forensic toxicology and seized drug analysis. Thermal degradation products have yet to be identified and evaluated for toxicity in comparison to parent and metabolic compounds. An investigation into these pyrolytic products, as the major route of ingestion is inhalation, may produce additional insight to understand the toxicity of synthetic cannabinoids. The pyrolysis of JWH-018 and 11 additional synthetic cannabinoids and six herbal plant substrates were conducted using an in-house constructed smoking simulator...
June 20, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28636944/transduction-of-repetitive-mechanical-stimuli-by-piezo1-and-piezo2-ion-channels
#2
Amanda H Lewis, Alisa F Cui, Malcolm F McDonald, Jörg Grandl
Several cell types experience repetitive mechanical stimuli, including vein endothelial cells during pulsating blood flow, inner ear hair cells upon sound exposure, and skin cells and their innervating dorsal root ganglion (DRG) neurons when sweeping across a textured surface or touching a vibrating object. While mechanosensitive Piezo ion channels have been clearly implicated in sensing static touch, their roles in transducing repetitive stimulations are less clear. Here, we perform electrophysiological recordings of heterologously expressed mouse Piezo1 and Piezo2 responding to repetitive mechanical stimulations...
June 20, 2017: Cell Reports
https://www.readbyqxmd.com/read/28636762/european-diabetes-research-and-its-funding-2002-2013
#3
M Begum, G Lewison, S Sommariva, O Ciani, R Tarricone, R Sullivan
AIM: This study examined the outputs of research papers in diabetes from 31 European countries between 2002 and 2013, and their funding. METHODS: Diabetes research papers in the Web of Science were identified by means of a filter based on journals and title words. For 2009-2013 papers, the funders were coded to show their sector and nationality. RESULTS: Europe published 40 547 diabetes papers in the 12 years between 2002 and 2013. Denmark, Sweden and Finland published the most relative to their wealth, but the UK published the most absolutely despite an apparently low burden (as measured by disability-adjusted life years)...
June 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28636601/crystal-structure-of-the-potassium-importing-kdpfabc-membrane-complex
#4
Ching-Shin Huang, Bjørn Panyella Pedersen, David L Stokes
Cellular potassium import systems play a fundamental role in osmoregulation, pH homeostasis and membrane potential in all domains of life. In bacteria, the kdp operon encodes a four-subunit potassium pump that maintains intracellular homeostasis, cell shape and turgor under conditions in which potassium is limiting. This membrane complex, called KdpFABC, has one channel-like subunit (KdpA) belonging to the superfamily of potassium transporters and another pump-like subunit (KdpB) belonging to the superfamily of P-type ATPases...
June 21, 2017: Nature
https://www.readbyqxmd.com/read/28635678/evaluation-of-classifier-performance-for-multiclass-phenotype-discrimination-in-untargeted-metabolomics
#5
Patrick J Trainor, Andrew P DeFilippis, Shesh N Rai
Statistical classification is a critical component of utilizing metabolomics data for examining the molecular determinants of phenotypes. Despite this, a comprehensive and rigorous evaluation of the accuracy of classification techniques for phenotype discrimination given metabolomics data has not been conducted. We conducted such an evaluation using both simulated and real metabolomics datasets, comparing Partial Least Squares-Discriminant Analysis (PLS-DA), Sparse PLS-DA, Random Forests, Support Vector Machines (SVM), Artificial Neural Network, k-Nearest Neighbors (k-NN), and Naïve Bayes classification techniques for discrimination...
June 21, 2017: Metabolites
https://www.readbyqxmd.com/read/28635670/single-lead-fetal-ecg-extraction-based-on-a-parallel-marginalized-particle-filter
#6
Zhidong Zhao, Huiling Tong, Yanjun Deng, Wen Xu, Yefei Zhang, Haihui Ye
This paper presents a novel method for extracting the fetal ECG (FECG) from a single-lead abdominal signal. A dynamical model for a modified abdominal signal is proposed, in which both the maternal ECG (MECG) and the FECG are modeled, and then a parallel marginalized particle filter (par-MPF) is used for tracking the abdominal signal. Finally, the FECG and MECG are simultaneously separated. Several experiments are conducted using both simulated and clinical signals. The results indicate that the method proposed in this paper effectively extracts the FECG and outperforms other Bayesian filtering algorithms...
June 21, 2017: Sensors
https://www.readbyqxmd.com/read/28635653/virtual-screening-against-phosphoglycerate-kinase-1-in-quest-of-novel-apoptosis-inhibitors
#7
Jie Xia, Bo Feng, Qianhang Shao, Yuhe Yuan, Xiang Simon Wang, Naihong Chen, Song Wu
Inhibition of apoptosis is a potential therapy to treat human diseases such as neurodegenerative disorders (e.g., Parkinson's disease), stroke, and sepsis. Due to the lack of druggable targets, it remains a major challenge to discover apoptosis inhibitors. The recent repositioning of a marketed drug (i.e., terazosin) as an anti-apoptotic agent uncovered a novel target (i.e., human phosphoglycerate kinase 1 (hPgk1)). In this study, we developed a virtual screening (VS) pipeline based on the X-ray structure of Pgk1/terazosin complex and applied it to a screening campaign for potential anti-apoptotic agents...
June 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28635621/the-charge-and-spin-transport-properties-in-hexagonal-silicene-nanorings
#8
Ning Xu, Haiyang Zhang, Xiuqiang Wu, Chen Qiao, Jian-Wen Ding
Based on the tight-binding model, charge and spin transport properties of hexagonal silicene rings are investigated within the nonequilibrium Green's function technique. The effects of external electric, magnetic and exchange fields are taken into account. The calculated results reveal that the hexagonal silicene nanorings act as a controllable spin filter. The near-perfect spin polarization can be achieved by adjusting electric, magnetic and exchange fields. The calculated results offer new possibilities for silicene ring based spin nanodevices...
June 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28635138/snake-spectacle-vessel-permeability-to-sodium-fluorescein
#9
Roy W Bellhorn, Ann R Strom, Monica J Motta, John Doval, Michelle G Hawkins, Joanne Paul-Murphy
OBJECTIVE: Assess vascular permeability of the snake spectacle to sodium fluorescein during resting and shedding phases of the ecdysis cycle. ANIMAL STUDIED: Ball python (Python regius). PROCEDURES: The snake was anesthetized, and spectral domain optic coherence tomography was performed prior to angiographic procedures. An electronically controlled digital single-lens reflex camera with a dual-head flash equipped with filters suitable for fluorescein angiography was used to make images...
June 20, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28634796/effects-of-perfluorooctanoic-acid-and-perfluorooctane-sulfonate-on-acute-toxicity-superoxide-dismutase-and-cellulase-activity-in-the-earthworm-eisenia-fetida
#10
Zuoqing Yuan, Jianyong Zhang, Lili Zhao, Jing Li, Hongbin Liu
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are the two best-known perfluorinated chemicals and have received much attention due to their ubiquity in the environment. In the present study, we evaluated the effects of PFOS and PFOA on acute toxicity, superoxide dismutase (SOD), and cellulase activities in Eisenia fetida. The results of acute toxicity testing using a filter paper contact test and a natural field soil test showed that PFOA and PFOS exhibited acute toxicity in earthworms, and the toxic effect of PFOS was greater than that of PFOA...
June 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28634756/a-high-throughput-targeted-and-non-targeted-method-for-the-analysis-of-microcystins-and-anatoxin-a-using-on-line-solid-phase-extraction-coupled-to-liquid-chromatography-quadrupole-time-of-flight-high-resolution-mass-spectrometry
#11
Xavier Ortiz, Eva Korenkova, Karl J Jobst, Karen A MacPherson, Eric J Reiner
Microcystins are cyclic heptapeptide hepatotoxins produced by cyanobacteria in freshwater. Sample preparation for the analysis of these cyanotoxins in water from algal blooms can take up to several days due to the matrix complexity and the low detection limits required to comply with current legislation. Moreover, there is a large number of unknown microcystins that could potentially exist in the environment resulting from different amino acid substitutions into the microcystin skeletal structure. To tackle these problems, the present study involved the development of a high throughput method based on on-line solid phase extraction coupled to liquid chromatography that could provide quantitative results for 12 microcystin variants (LR, YR, RR, HtyR, HilR, WR, LW, LA, LF, LY, Dha(7)-LR, and Dha(7)-RR) and anatoxin-A in less than 3 h with detection limits between 0...
June 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28634701/the-50-most-cited-articles-in-facial-plastic-surgery
#12
Michael T Chang, Zachary G Schwam, Christopher A Schutt, Emily M Kamen, Boris Paskhover
Bibliometric analysis is a common method to determine the most influential articles in medical specialties, as it is an objective measure of peer recognition of scientific work. This study is the first bibliometric analysis of the literature in facial plastic surgery, to determine the most cited papers in the field. Bibliometric analysis was performed using the Science Citation Index from the Institute for Scientific Information, accessed through the Web of Science™. Filter terms relevant to the field of facial plastic surgery were used to identify the 50 most cited journal articles between 1900 and 2016...
June 20, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28634475/cesarean-or-vaginal-birth-does-not-impact-the-longitudinal-development-of-the-gut-microbiome-in-a-cohort-of-exclusively-preterm-infants
#13
Christopher J Stewart, Nicholas D Embleton, Elizabeth Clements, Pamela N Luna, Daniel P Smith, Tatiana Y Fofanova, Andrew Nelson, Gillian Taylor, Caroline H Orr, Joseph F Petrosino, Janet E Berrington, Stephen P Cummings
The short and long-term impact of birth mode on the developing gut microbiome in neonates has potential implications for the health of infants. In term infants, the microbiome immediately following birth across multiple body sites corresponds to birth mode, with increased Bacteroides in vaginally delivered infants. We aimed to determine the impact of birth mode of the preterm gut microbiome over the first 100 days of life and following neonatal intensive care unit (NICU) discharge. In total, 867 stool samples from 46 preterm infants (21 cesarean and 25 vaginal), median gestational age 27 weeks, were sequenced (V4 region 16S rRNA gene, Illumina MiSeq)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28634449/electromyography-data-processing-impacts-muscle-synergies-during-gait-for-unimpaired-children-and-children-with-cerebral-palsy
#14
Benjamin R Shuman, Michael H Schwartz, Katherine M Steele
Muscle synergies calculated from electromyography (EMG) data identify weighted groups of muscles activated together during functional tasks. Research has shown that fewer synergies are required to describe EMG data of individuals with neurologic impairments. When considering potential clinical applications of synergies, understanding how EMG data processing impacts results and clinical interpretation is important. The aim of this study was to evaluate how EMG signal processing impacts synergy outputs during gait...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28634086/towards-building-a-more-complex-view-of-the-lateral-geniculate-nucleus-recent-advances-in-understanding-its-role
#15
REVIEW
Masoud Ghodrati, Seyed-Mahdi Khaligh-Razavi, Sidney R Lehky
The lateral geniculate nucleus (LGN) has often been treated in the past as a linear filter that adds little to retinal processing of visual inputs. Here we review anatomical, neurophysiological, brain imaging, and modeling studies that have in recent years built up a much more complex view of LGN. These include effects related to nonlinear dendritic processing, cortical feedback, synchrony and oscillations across LGN populations, as well as involvement of LGN in higher level cognitive processing Although recent studies have provided valuable insights into early visual processing including the role of LGN, a unified model of LGN responses to real-world objects has not yet been developed...
June 17, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28633113/transformation-and-toxicity-assessment-of-two-uv-filters-using-uv-h2o2-process
#16
Mingguo Peng, Erdeng Du, Zhihong Li, Dongdong Li, Huajie Li
The treatment of two typical UV filters benzophenone-4 (BP4) and benzophenone-9 (BP9) was evaluated in aqueous solutions by UV/H2O2 process. High-resolution accurate mass spectrometry (HRMS) was used to identify the degradation intermediates. A total of 12 BP4 degradation products and 17 BP9 degradation products were identified. A series of OH-initiated reactions, including hydroxylation, dihydroxylation, decarboxylation, demethylation, and ring breaking, lead to the final mineralization of BP4 and BP9. The degradation mechanisms of BP4 and BP9 are also proposed, separately...
June 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28632740/soft-bilateral-filtering-volumetric-shadows-using-cube-shadow-maps
#17
Hatam H Ali, Mohd Shahrizal Sunar, Hoshang Kolivand
Volumetric shadows often increase the realism of rendered scenes in computer graphics. Typical volumetric shadows techniques do not provide a smooth transition effect in real-time with conservation on crispness of boundaries. This research presents a new technique for generating high quality volumetric shadows by sampling and interpolation. Contrary to conventional ray marching method, which requires extensive time, this proposed technique adopts downsampling in calculating ray marching. Furthermore, light scattering is computed in High Dynamic Range buffer to generate tone mapping...
2017: PloS One
https://www.readbyqxmd.com/read/28632737/supervised-filters-for-eeg-signal-in-naturally-occurring-epilepsy-forecasting
#18
Francisco Javier Muñoz-Almaraz, Francisco Zamora-Martínez, Paloma Botella-Rocamora, Juan Pardo
Nearly 1% of the global population has Epilepsy. Forecasting epileptic seizures with an acceptable confidence level, could improve the disease treatment and thus the lifestyle of the people who suffer it. To do that the electroencephalogram (EEG) signal is usually studied through spectral power band filtering, but this paper proposes an alternative novel method of preprocessing the EEG signal based on supervised filters. Such filters have been employed in a machine learning algorithm, such as the K-Nearest Neighbor (KNN), to improve the prediction of seizures...
2017: PloS One
https://www.readbyqxmd.com/read/28631281/detecting-large-scale-networks-in-the-human-brain-using-high-density-electroencephalography
#19
Quanying Liu, Seyedehrezvan Farahibozorg, Camillo Porcaro, Nicole Wenderoth, Dante Mantini
High-density electroencephalography (hdEEG) is an emerging brain imaging technique that can be used to investigate fast dynamics of electrical activity in the healthy and the diseased human brain. Its applications are however currently limited by a number of methodological issues, among which the difficulty in obtaining accurate source localizations. In particular, these issues have so far prevented EEG studies from reporting brain networks similar to those previously detected by functional magnetic resonance imaging (fMRI)...
June 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28631220/applicability-of-upflow-anaerobic-sludge-blanket-and-dynamic-membrane-coupled-process-for-the-treatment-of-municipal-wastewater
#20
Pei Jun Quek, Tsuey Shan Yeap, How Yong Ng
This study investigated the applicability of dynamic membrane filter (DMF) technology in an upflow anaerobic sludge blanket (UASB) and DMF-coupled process for the treatment of municipal wastewater. The overall treatment performance and effects of hydraulic retention time (HRT), operating flux, and mesh pore size on the UASB + DMF were assessed. The UASB + DMF-coupled process demonstrated removal efficiencies of over 64 and 86% for TCOD and TSS, respectively. The effects of filtration flux and support mesh pore size were investigated and it was found that while there was little impact on the treatment performance, a 67% increase in operating flux resulted in a 25% increase in fouling rate...
June 19, 2017: Applied Microbiology and Biotechnology
keyword
keyword
63389
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"