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https://www.readbyqxmd.com/read/28212540/expression-of-met-in-circulating-tumor-cells-correlates-with-expression-in-tumor-tissue-from-advanced-stage-lung-cancer-patients
#1
Marius Ilie, Edith Szafer-Glusman, Véronique Hofman, Elodie Long-Mira, Rebecca Suttmann, Walter Darbonne, Catherine Butori, Salomé Lalvée, Julien Fayada, Eric Selva, Wei Yu, Charles-Hugo Marquette, David S Shames, Elizabeth Punnoose, Paul Hofman
Given the difficulty in obtaining adequate tissue in NSCLC, we investigated the utility of circulating tumor cells (CTCs) for MET status assessment in NSCLC patients. We used two platforms for CTC capture, and assessed MET expression in CTCs and matched-bronchial biopsies in patients with advanced-stage III/IV lung adenocarcinoma. Baseline peripheral blood was collected from 256 advanced-stage III/IV NSCLC patients from Genentech clinical trials, and from 106 patients with advanced-stage III/IV lung adenocarcinoma treated at the Department of Pneumology, Pasteur Hospital, Nice...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212418/experimental-evidence-of-formation-of-transparent-exopolymer-particles-tep-and-poc-export-provoked-by-dust-addition-under-current-and-high-pco2-conditions
#2
Justine Louis, Maria Luiza Pedrotti, Frédéric Gazeau, Cécile Guieu
The evolution of organic carbon export to the deep ocean, under anthropogenic forcing such as ocean warming and acidification, needs to be investigated in order to evaluate potential positive or negative feedbacks on atmospheric CO2 concentrations, and therefore on climate. As such, modifications of aggregation processes driven by transparent exopolymer particles (TEP) formation have the potential to affect carbon export. The objectives of this study were to experimentally assess the dynamics of organic matter, after the simulation of a Saharan dust deposition event, through the measurement over one week of TEP abundance and size, and to evaluate the effects of ocean acidification on TEP formation and carbon export following a dust deposition event...
2017: PloS One
https://www.readbyqxmd.com/read/28212409/pathogenic-waterborne-free-living-amoebae-an-update-from-selected-southeast-asian-countries
#3
Mohamad Azlan Abdul Majid, Tooba Mahboob, Brandon G J Mong, Narong Jaturas, Reena Leeba Richard, Tan Tian-Chye, Anusorn Phimphila, Panomphanh Mahaphonh, Kyaw Nyein Aye, Wai Lynn Aung, Joon Chuah, Alan D Ziegler, Atipat Yasiri, Nongyao Sawangjaroen, Yvonne A L Lim, Veeranoot Nissapatorn
Data on the distribution of free-living amoebae is still lacking especially in Southeast Asian region. The aquatic environment revealed a high occurrence of free-living amoebae (FLA) due to its suitable condition and availability of food source, which subsequently causes infection to humans. A total of 94 water samples consisted of both treated and untreated from Laos (31), Myanmar (42), and Singapore (21) were investigated for the presence of pathogenic FLA. Each water sample was filtered and cultured onto non-nutrient agar seeded with live suspension of Escherichia coli and incubated at room temperature...
2017: PloS One
https://www.readbyqxmd.com/read/28212382/de-novo-assembly-of-the-sea-trout-salmo-trutta-m-trutta-skin-transcriptome-to-identify-putative-genes-involved-in-the-immune-response-and-epidermal-mucus-secretion
#4
Magdalena Malachowicz, Roman Wenne, Artur Burzynski
In fish, the skin is a multifunctional organ and the first barrier against pathogens. Salmonids differ in their susceptibility to microorganisms due to varied skin morphology and gene expression patterns. The brown trout is a salmonid species with important commercial and ecological value in Europe. However, there is a lack of knowledge regarding the genes involved in the immune response and mucus secretion in the skin of this fish. Thus, we characterized the skin transcriptome of anadromous brown trout using next-generation sequencing (NGS)...
2017: PloS One
https://www.readbyqxmd.com/read/28212291/tracking-the-turn-maneuvering-target-using-the-multi-target-bayes-filter-with-an-adaptive-estimation-of-turn-rate
#5
Zong-Xiang Liu, De-Hui Wu, Wei-Xin Xie, Liang-Qun Li
Tracking the target that maneuvers at a variable turn rate is a challenging problem. The traditional solution for this problem is the use of the switching multiple models technique, which includes several dynamic models with different turn rates for matching the motion mode of the target at each point in time. However, the actual motion mode of a target at any time may be different from all of the dynamic models, because these models are usually limited. To address this problem, we establish a formula for estimating the turn rate of a maneuvering target...
February 15, 2017: Sensors
https://www.readbyqxmd.com/read/28212096/system-level-design-of-a-64-channel-low-power-neural-spike-recording-sensor
#6
Manuel Delgado-Restituto, Alberto Rodriguez-Perez, Angela Darie, Cristina Soto-Sanchez, Eduardo Fernandez-Jover, Angel Rodriguez-Vazquez
This paper reports an integrated 64-channel neural spike recording sensor, together with all the circuitry to process and configure the channels, process the neural data, transmit via a wireless link the information and receive the required instructions. Neural signals are acquired, filtered, digitized and compressed in the channels. Additionally, each channel implements an auto-calibration algorithm which individually configures the transfer characteristics of the recording site. The system has two transmission modes; in one case the information captured by the channels is sent as uncompressed raw data; in the other, feature vectors extracted from the detected neural spikes are released...
February 13, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28212085/contextual-noise-reduction-for-domain-adaptive-near-duplicate-retrieval-on-merchandize-images
#7
Zhen-Qun Yang, Xiao-Yong Wei, Zhang Yi, Gerald Friedland
In this paper, we have proposed a novel method which utilizes the contextual relationship among visual words for reducing the Quantization errors in near-duplicate image retrieval (NDR). Instead of following the track of conventional NDR techniques which usually search new solutions by borrowing ideas from the text domain, we propose to model the problem back to image domain, which results in a more natural way of solution search. The idea of the proposed method is to construct a context graph that encapsulates the contextual relationship within an image and treat the graph as a pseudo-image, so that classical image filters can be adopted to reduce the mismapped visual words which are contextually inconsistent with others...
February 15, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28212077/robust-guided-image-filtering-using-nonconvex-potentials
#8
Bumsub Ham, Minsu Cho, Jean Ponce
Filtering images using a guidance signal, a process called guided or joint image filtering, has been used in various tasks in computer vision and computational photography, particularly for noise reduction and joint upsampling. This uses an additional guidance signal as a structure prior, and transfers the structure of the guidance signal to an input image, restoring noisy or altered image structure. The main drawbacks of such a data-dependent framework are that it does not consider structural differences between guidance and input images, and that it is not robust to outliers...
February 14, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28212075/towards-photoplethysmography-based-estimation-of-instantaneous-heart-rate-during-physical-activity
#9
Delaram Jarchi, Alex Casson
OBJECTIVE: Recently numerous methods have been proposed for estimating average heart rate using photoplethysmography (PPG) during physical activity, overcoming the significant interference that motion causes in PPG traces. We propose a new algorithm framework for extracting instantaneous heart rate from wearable PPG and ECG signals to provide an estimate of heart rate variability during exercise. METHODS: For ECG signals we propose a new spectral masking approach which modifies a particle filter tracking algorithm, and for PPG signals constrains the instantaneous frequency obtained from the Hilbert transform to a region of interest around a candidate heart rate measure...
February 13, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28212006/effect-of-sand-bed-depth-and-media-age-on-escherichia-coli-and-turbidity-removal-in-biosand-filters
#10
Julie A Napotnik, Derek Baker, Kristen L Jellison
The main objective of this study was to build several full-scale biosand filters (BSFs) and assess the long-term (9 month) efficacy for particulate and Escherichia coli removal under simulated real-world usage. Four replicates of three different filter designs were built: the traditional concrete BSF, and two scaled-down versions that use a 5-gal or 2-gal bucket, respectively, as the casing material. The smaller sand bed depths in the bucket-sized filters did not impact filter performance with respect to (i) turbidity and E...
February 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28211506/wide-band-angle-blazed-surfaces-using-multiple-coupled-blazing-resonances
#11
Mohammad Memarian, Xiaoqiang Li, Yasuo Morimoto, Tatsuo Itoh
Blazed gratings can reflect an oblique incident wave back in the path of incidence, unlike mirrors and metal plates that only reflect specular waves. Perfect blazing (and zero specular scattering) is a type of Wood's anomaly that has been observed when a resonance condition occurs in the unit-cell of the blazed grating. Such elusive anomalies have been studied thus far as individual perfect blazing points. In this work, we present reflective blazed surfaces that, by design, have multiple coupled blazing resonances per cell...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211332/3-3-dichlorobiphenyl-non-aroclor-pcb-11-as-a-marker-of-non-legacy-pcb-contamination-in-marine-species-comparison-between-antarctic-and-mediterranean-bivalves
#12
Sarah Pizzini, Chiara Sbicego, Fabiana Corami, Marco Grotti, Emanuele Magi, Tiziano Bonato, Giulio Cozzi, Carlo Barbante, Rossano Piazza
In this study the accumulation of the 3,3'-dichlorobiphenyl (PCB-11) in monitoring organisms from the Antarctic and Mediterranean coastal environments has been investigated. This lesser-known PCB congener, unrelated to the industrial use of commercial mixtures, continues to be generated and released into the environment mainly as an unintentional by-product of pigment manufacturing. Specimens of the filter-feeders Adamussium colbecki from Terra Nova Bay and of Mytilus galloprovincialis and Ruditapes philippinarum from the north-western Adriatic coasts were collected and analyzed for PCB-11 by Gas Chromatography coupled both to Low-Resolution and High-Resolution Mass Spectrometry (LRMS, HRMS)...
February 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28211288/imaging-evaluating-of-the-implant-bone-interface-an-in-vitro-radiographic-study
#13
M M Vidor, G S Liedke, M B Vizzotto, Hld da Silveira, P F da Silveira, C W Araujo, Hed da Silveira
OBJECTIVES: To analyze the diagnostic accuracy of conventional and digital radiographic images and the impact of digital filters in evaluating the bone/implant interface. METHODS: Titanium implants were inserted into 74 fresh bovine ribs blocks, 37 fitting tight to the bone walls (simulating the existence of osseointegration), and 37 with a gap of 0.125 mm (simulating a failure in the osseointegration process). Periapical radiographs were taken with conventional film and two phosphor-plate systems (Vista Scan and Express)...
February 17, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28211276/tuning-the-pseudospin-polarization-of-graphene-by-a-pseudo-magnetic-field
#14
Alexander Georgi, Peter Nemes-Incze, Ramon Carrillo-Bastos, Daiara Faria, Silvia Viola Kusminskiy, Dawei Zhai, Martin Schneider, Dinesh Subramaniam, Torge Mashoff, Nils Michael Freitag, Marcus Liebmann, Marco Pratzer, Ludger Wirtz, Colin R Woods, Roman Vladislavovich Gorbachev, Yang Cao, Kostya S Novoselov, Nancy Sandler, Markus Morgenstern
One of the intriguing characteristics of honeycomb lattices is the appearance of a pseudo-magnetic field as a result of mechanical deformation. In the case of graphene, the Landau quantization resulting from this pseudo-magnetic field has been measured using scanning tunneling microscopy. Here we show that a signature of the pseudo-magnetic field is a local sublattice symmetry breaking observable as a redistribution of the local density of states. This can be interpreted as a polarization of graphene's pseudospin due to a strain induced pseudo-magnetic field, in analogy to the alignment of a real spin in a magnetic field...
February 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28210977/genetic-characterization-of-adenoid-cystic-carcinoma-of-the-minor-salivary-glands-a-potential-familial-occurrence-in-first-degree-relatives
#15
Hani Ibrahim Channir, Thomas van Overeem Hansen, Simon Andreasen, Christina Westmose Yde, Katalin Kiss, Birgitte Wittenborg Charabi
Adenoid cystic carcinoma (AdCC) is a malignant salivary gland tumor. To date, no cases of AdCC in first-degree relatives have been reported in the literature. We present a 50-year-old female (Case 1) and this patients' father (Case 2), both of whom were diagnosed with AdCC of the minor salivary glands. Histology of Case 1 demonstrated a tubulocribriform AdCC whereas Case 2 primarily was an AdCC of solid type. Both cases harbored the MYB-NFIB gene fusion as demonstrated by FISH and RNA-sequencing. After filtering and selection of putative deleterious variants, whole exome sequencing identified 18 germline variants in common between Case 1 and Case 2...
February 16, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28210953/combined-toxicity-of-imidacloprid-and-three-insecticides-to-the-earthworm-eisenia-fetida-annelida-oligochaeta
#16
Tao Cang, Dejiang Dai, Guiling Yang, Yijun Yu, Lu Lv, Leiming Cai, Qiang Wang, Yanhua Wang
Although the earthworm Eisenia fetida has been used in many ecotoxicological studies in recent years, most of these studies have only focused on assessing the effects of individual insecticides. In the present study, we aimed to compare the individual and combined toxic effects of imidacloprid and three insecticides (phoxim, chlorpyrifos, and lambda-cyhalothrin) on E. fetida. We showed that imidacloprid had the highest intrinsic toxicity to the worms in filter paper contact test, followed by phoxim and lambda-cyhalothrin, while the least toxicity was found from chlorpyrifos...
February 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28210719/clogging-transition-induced-by-self-filtration-in-a-slit-pore
#17
B Dersoir, A B Schofield, H Tabuteau
Particles that flow through porous environments like soils, inside a filter or within our arteries, often lead to pore clogging. Even though tremendous efforts have been made in analysing this to circumvent this issue, the clog formation and its dynamics remain poorly understood. Coupling two experimental techniques, we elucidate the clogging mechanism at the particle scale of a slit pore with its height slightly larger than the particle diameter. We identify all the particle deposition modes during the clog formation and accurately predict the corresponding deposition rate...
February 17, 2017: Soft Matter
https://www.readbyqxmd.com/read/28210234/a-spiking-neuron-model-of-word-associations-for-the-remote-associates-test
#18
Ivana Kajić, Jan Gosmann, Terrence C Stewart, Thomas Wennekers, Chris Eliasmith
Generating associations is important for cognitive tasks including language acquisition and creative problem solving. It remains an open question how the brain represents and processes associations. The Remote Associates Test (RAT) is a task, originally used in creativity research, that is heavily dependent on generating associations in a search for the solutions to individual RAT problems. In this work we present a model that solves the test. Compared to earlier modeling work on the RAT, our hybrid (i.e., non-developmental) model is implemented in a spiking neural network by means of the Neural Engineering Framework (NEF), demonstrating that it is possible for spiking neurons to be organized to store the employed representations and to manipulate them...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28210224/skin-mucus-of-gilthead-sea-bream-sparus-aurata-l-protein-mapping-and-regulation-in-chronically-stressed-fish
#19
Jaume Pérez-Sánchez, Genciana Terova, Paula Simó-Mirabet, Simona Rimoldi, Ole Folkedal, Josep A Calduch-Giner, Rolf E Olsen, Ariadna Sitjà-Bobadilla
The skin mucus of gilthead sea bream was mapped by one-dimensional gel electrophoresis followed by liquid chromatography coupled to high resolution mass spectrometry using a quadrupole time-of-flight mass analyzer. More than 2,000 proteins were identified with a protein score filter of 30. The identified proteins were represented in 418 canonical pathways of the Ingenuity Pathway software. After filtering by canonical pathway overlapping, the retained proteins were clustered in three groups. The mitochondrial cluster contained 59 proteins related to oxidative phosphorylation and mitochondrial dysfunction...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28209483/a-new-size-based-platform-for-circulating-tumor-cell-detection-in-colorectal-cancer-patients
#20
Bo Young Oh, Jhingook Kim, Woo Yong Lee, Hee Cheol Kim
BACKGROUND: Circulating tumor cells (CTCs) might play a significant role in cancer progression and metastasis. However, the ability to detect CTCs is limited, especially in cells undergoing epithelial-mesenchymal transition. In this study, we evaluated a new size-based CTC detection platform and its clinical efficacy in colorectal cancer. PATIENTS AND METHODS: Blood samples were obtained from 76 patients with colorectal cancer and 20 healthy control subjects for CTC analysis...
January 25, 2017: Clinical Colorectal Cancer
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