Read by QxMD icon Read


Corinthia Fabien-Dupuis, Benjamin Niver, Nick Shillingford, Larry Wang, Paul J Kokorowski, Shengmei Zhou
Testicular melanotic neuroectodermal tumor of infancy (MNTI) is extremely rare, with 2 cases reported in the literature. Its rarity and rapid and infiltrative growth pattern pose a diagnostic challenge. A previously healthy 3-month-old male, presented with a history of worsening left hemiscrotal swelling for 1 week. An outside ultrasound was suggestive of testicular torsion. Left orchiectomy demonstrated a mass occupying almost entire testicle with a variegated cut surface, with areas of pigmentation, necrosis, and hemorrhage...
September 2017: Pediatric and Developmental Pathology
Matthew J O'Hara, Anthony J Krzysko, Cynthia M Niver, Samuel S Morrison, Stanley L Owsley, Donald K Hamlin, Eric F Dorman, D Scott Wilbur
Astatine-211 (211 At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy. The wet chemical isolation of trace quantities of211 At, produced within several grams of Bi metal deposited onto an aluminum cyclotron target assembly, involves a multi-step procedure. Because the211 At isolation method is labor-intensive and complex, automation of the method is being developed to facilitate routine processing at the University of Washington and to make it easier to transfer the process to other institutions...
April 2017: Applied Radiation and Isotopes
Elena W Adlaf, Ryan J Vaden, Anastasia J Niver, Allison F Manuel, Vincent C Onyilo, Matheus T Araujo, Cristina V Dieni, Hai T Vo, Gwendalyn D King, Jacques I Wadiche, Linda Overstreet-Wadiche
Adult-born neurons are continually produced in the dentate gyrus but it is unclear whether synaptic integration of new neurons affects the pre-existing circuit. Here we investigated how manipulating neurogenesis in adult mice alters excitatory synaptic transmission to mature dentate neurons. Enhancing neurogenesis by conditional deletion of the pro-apoptotic gene Bax in stem cells reduced excitatory postsynaptic currents (EPSCs) and spine density in mature neurons, whereas genetic ablation of neurogenesis increased EPSCs in mature neurons...
January 30, 2017: ELife
Ben E Niver, Siamak Daneshmand, Raj Satkunasivam
PURPOSE OF REVIEW: Surgical techniques to spare female reproductive organs at the time of radical cystectomy [reproductive organ-sparing radical cystectomy (ROSRC)] have been advocated to improve quality of life with respect to sexual and urinary function. These potential benefits must be weighed against the risk of inappropriate patient selection and related oncologic risk. RECENT FINDINGS: In this review, we describe the evidence to define the appropriate selection criteria to minimize clinical understaging...
March 2015: Current Opinion in Urology
Ellen Goldmark, Benjamin Niver, David A Ginsberg
Patients with spinal cord injury (SCI) present with a wide range and variety of urologic manifestations, depending upon the level of injury. Historically, patients with spinal cord injury experienced significant mortality related to renal failure. Greater knowledge of the pathophysiology of SCI, however, has contributed to a reduction in mortality. It is essential to perform a thorough initial evaluation and regular follow-up of these patients to achieve the primary goal of preservation of renal function, with the secondary goal of optimizing the patient's quality of life...
October 2014: Current Urology Reports
Dominic Mintalucci, Kevin F Lutsky, Jonas L Matzon, Michael Rivlin, Genghis Niver, Pedro K Beredjiklian
PURPOSE: To determine the radiographic dimensions of the distal interphalangeal (DIP) joint and to compare these measurements with commonly used headless compression screws. METHODS: Using standard posteroanterior and lateral radiographs of the hand, we measured the dimensions of the distal and middle phalanges in 60 index, middle, ring, and little fingers. We then compared these measurements with the diameters and lengths of 16 commercially available headless compression screws commonly used to perform DIP joint arthrodesis...
June 2014: Journal of Hand Surgery
Danielle Niver
Bronchopulmonary dysplasia (BPD) continues to be a significant cause of morbidity and mortality for premature infants. Currently, most treatment strategies are mainly palliative and do not address the underlying structural changes of the lungs leading to the symptoms. New research and ongoing experiments with mesenchymal stem cells are showing capabilities to mitigate structural damage and promote vascular growth that leads to normal lung architecture in animal models. Looking at the pathophysiology that contributes to BPD and assessing current treatment options available, there still appears to be a gap in treatment that addresses the structural issues within the lungs...
February 2014: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Genghis E Niver, Asif M Ilyas
Radial nerve palsy is the most common peripheral nerve injury following a humerus fracture, occurring in 2% to 17% of cases. Radial nerve palsies associated with closed humerus fractures have traditionally been treated with observation, with late exploration restricted to cases without spontaneous nerve recovery at 3 to 6 months. Advocates for early exploration believe that late exploration can result in increased muscular atrophy, motor endplate loss, compromised nerve recovery upon delayed repair, and significant interval loss of patient function and livelihood...
July 2013: Orthopedic Clinics of North America
Genghis E Niver, Asif M Ilyas
Carpal tunnel syndrome is a common condition and is a well-recognized phenomenon following a distal radius fracture. The treating surgeon should be vigilant in noticing the signs and symptoms. If acute carpal tunnel syndrome is noted, then surgical release of the carpal tunnel and fracture fixation should be performed urgently. If early carpal tunnel syndrome findings are noted during distal radius fracture management, all potential causes should be evaluated. Delayed carpal tunnel syndrome presenting after a distal radius fracture has healed is best managed in standard fashion...
October 2012: Orthopedic Clinics of North America
Andrew B Rosenkrantz, Eric E Sigmund, Aaron Winnick, Benjamin E Niver, Bradley Spieler, Glyn R Morgan, Cristina H Hajdu
OBJECTIVES: The objective was to perform ex vivo evaluation of non-Gaussian diffusion kurtosis imaging (DKI) for assessment of hepatocellular carcinoma (HCC), including presence of treatment-related necrosis, using fresh liver explants. METHODS: Twelve liver explants underwent 1.5-T magnetic resonance imaging using a DKI sequence with maximal b-value of 2000 s/mm(2). A standard monoexponential fit was used to calculate apparent diffusion coefficient (ADC), and a non-Gaussian kurtosis fit was used to calculate K, a measure of excess kurtosis of diffusion, and D, a corrected diffusion coefficient accounting for this non-Gaussian behavior...
December 2012: Magnetic Resonance Imaging
Ben E Niver, Ilir Agalliu, Romy Bareket, Patrick Mufarrij, Ojas Shah, Michael D Stifelman
OBJECTIVE: To analyze the outcomes of our robotic-assisted pyeloplasty series for primary ureteropelvic junction obstruction (UPJO) and compare them with our series of robotic-assisted pyeloplasty for secondary UPJO. The repair of secondary UPJO can pose additional challenges to surgeons. Robotic assistance could aid in these repairs. METHODS: Using an institutional review board-approved database, we reviewed 119 consecutive patients who had undergone robotic-assisted laparoscopic pyeloplasty at our institution during an 8-year period (May 2002 to February 2010)...
March 2012: Urology
Andrew B Rosenkrantz, Pippa Storey, Anthony G Gilet, Benjamin E Niver, James S Babb, Cristina H Hajdu, Vivian S Lee
PURPOSE: To evaluate the ability of magnetization transfer (MT) contrast-prepared magnetic resonance (MR) imaging to help distinguish healthy from cirrhotic liver by using a spectrum of MT pulse frequency offsets. MATERIALS AND METHODS: This HIPAA-compliant prospective study was approved by the institutional review board. Written informed consent was obtained from all subjects. After optimization of the MT sequence by using agar phantoms with protein concentrations ranging from 0% to 4%, 20 patients with cirrhosis and portal hypertension and 20 healthy volunteers with no known liver disease underwent liver MR imaging that included eight separate breath-hold MT contrast sequences, each performed by using a different MT pulse frequency offset (range, 200-2500 Hz)...
January 2012: Radiology
E L Niver, N Leong, J Greene, D Curtis, M I Ryder, S P Ho
BACKGROUND AND OBJECTIVE: Adaptive properties of the bone-periodontal ligament-tooth complex have been identified by changing the magnitude of functional loads using small-scale animal models, such as rodents. Reported adaptive responses as a result of lower loads due to softer diet include decreased muscle development, change in structure-function relationship of the cranium, narrowed periodontal ligament space, and changes in the mineral level of the cortical bone and alveolar jaw bone and in the glycosaminoglycans of the alveolar bone...
December 2011: Journal of Periodontal Research
Knut Beitzel, Elifho Obopilwe, David M Chowaniec, Genghis E Niver, Michael D Nowak, Bryan T Hanypsiak, James J Guerra, Robert A Arciero, Augustus D Mazzocca
BACKGROUND: Arthroscopic procedures for reconstruction of acromioclavicular (AC) joint separations are increasingly used in clinical practice. Multiple surgical techniques exist, but there are still few data on biomechanical performances of commonly used arthroscopic techniques and fixation methods. HYPOTHESIS: Single and double clavicular tunnel reconstructions show comparable primary stability with a modified Weaver-Dunn procedure, and double tunnel constructs show superior horizontal stability...
October 2011: American Journal of Sports Medicine
Andrew B Rosenkrantz, Lorenzo Mannelli, Xiangtian Kong, Ben E Niver, Douglas S Berkman, James S Babb, Jonathan Melamed, Samir S Taneja
PURPOSE: To retrospectively assess the utility of fusion of T2-weighted images (T2WI) and high b-value diffusion-weighted images (DWI) for prostate cancer detection and localization. MATERIALS AND METHODS: In this IRB-approved HIPAA-compliant study, 42 patients with prostate cancer underwent MRI including multiplanar T2WI and axial DWI before prostatectomy. Two independent radiologists first assessed multiplanar T2WI and axial DWI(b-1000) images and recorded whether tumor was present in each sextant...
July 2011: Journal of Magnetic Resonance Imaging: JMRI
Andrew B Rosenkrantz, Benjamin E Niver, Martin Kopec, Douglas S Berkman, Herbert Lepor, James S Babb, Elizabeth M Hecht
OBJECTIVE: The purpose of this study was to assess the possible clinical significance of bladder urine T1 hyperintensity based upon comparison with urinalysis findings, using a cohort of patients who underwent prostate MRI and urinalysis at a similar point in time during preoperative work-up. METHODS: We identified 56 patients who underwent prostatectomy at our institution who obtained prostate MRI and urinalysis within 1 day of each other preoperatively. A control group of 160 consecutive adult men who underwent pelvic MRI during the same time period for other indications was also identified...
May 2011: Clinical Imaging
B E Niver, A J Megibow, M J Faust, A B Rosenkrantz
No abstract text is available yet for this article.
July 2011: Clinical Radiology
Andrew B Rosenkrantz, Marcel Oei, James S Babb, Benjamin E Niver, Bachir Taouli
PURPOSE: To compare single-shot echo-planar imaging (SS EPI) diffusion-weighted MRI (DWI) of abdominal organs between 1.5 Tesla (T) and 3.0T in healthy volunteers in terms of image quality, apparent diffusion coefficient (ADC) values, and ADC reproducibility. MATERIALS AND METHODS: Eight healthy volunteers were prospectively imaged in this HIPAA-compliant IRB-approved study. Each subject underwent two consecutive scans at both 1.5 and 3.0T, which included breathhold and free-breathing DWI using a wide range of b-values (0 to 800 s/mm²)...
January 2011: Journal of Magnetic Resonance Imaging: JMRI
Andrew B Rosenkrantz, Xiangtian Kong, Benjamin E Niver, Douglas S Berkman, Jonathan Melamed, James S Babb, Samir S Taneja
OBJECTIVE: The purpose of our study was to compare the visibility of prostate cancer on trace diffusion-weighted (DW) images and the apparent diffusion coefficient (ADC) map. MATERIALS AND METHODS: In this retrospective study, 45 patients with prostate cancer underwent preoperative MRI, including DW imaging (DWI) (b values 0, 500, and 1,000 s/mm(2)). A single observer reviewed the images in conjunction with tumor maps constructed from prostatectomy. For 132 peripheral zone (PZ) tumor foci, the visibility and contrast relative to benign PZ were recorded for T2-weighted imaging, trace DWI b500 images, trace DWI b1,000 images, and ADC maps...
January 2011: AJR. American Journal of Roentgenology
Andrew B Rosenkrantz, Nicole Hindman, Erin F Fitzgerald, Benjamin E Niver, Jonathan Melamed, James S Babb
OBJECTIVE: The purpose of this study was to retrospectively describe the MRI features of the pathologically related entities renal oncocytoma and chromophobe renal cell carcinoma (RCC). MATERIALS AND METHODS: Twenty-eight cases of histologically proven renal oncocytoma and 15 of chromophobe RCC evaluated with preoperative MRI from January 2003 through June 2009 at our institution were independently reviewed for an array of MRI features by two radiologists blinded to the final histopathologic diagnosis...
December 2010: AJR. American Journal of Roentgenology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"