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https://www.readbyqxmd.com/read/27879294/cxcr2-is-involved-in-pulmonary-intravascular-macrophage-accumulation-and-angiogenesis-in-a-rat-model-of-hepatopulmonary-syndrome
#1
Xujiong Li, Yunxia Chen, Yongli Chang, Shufen Li, Zhongfu Zhao, HuiYing Zhang
Hepatopulmonary syndrome (HPS) is a lung complication in various liver diseases, with high incidence, poor prognosis and no effective non-surgical treatments in patients with hepatocirrhosis. Therefore, assessing HPS pathogenesis to explore proper therapy strategies is clinically relevant. In this study, male Sprague-Dawley rats underwent sham operation or common bile duct ligation (CBDL). Two weeks post-surgery, the following groups were setup for 2 weeks of treatment: Sham + normal saline, CBDL + CXCR2 antagonist SB225002, CBDL + TNF-α antagonist PTX, and CBDL + normal saline groups...
November 22, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27851335/1700-va-ecmo-for-a-pediatric-patient-with-worsening-hepatopulmonary-syndrome-following-liver-transplant
#2
Laura Schroeder, Gregory Yurasek, Khalid Khan, David Steinhorn
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27833324/hepatocellular-carcinoma-with-intra-atrial-tumor-extension-identified-on-99m-tc-labeled-macroaggregated-albumin-single-photon-emission-computed-tomography-computed-tomography
#3
Piyush Chandra, Sneha Shah, Nilendu Purandare, Archi Agrawal, Venkatesh Rangarajan
(99)mTc macroaggregated albumin (MAA) scintigraphy is always performed before administration of (90)Y--microspheres for the treatment of liver tumors for hepatopulmonary shunt calculation. Tumor thrombus visualization in the hepatic vasculature is an infrequent finding on the (99)m Tc--MAA single photon emission computed tomography. We present a rare case of a hepatocellular carcinoma extending as a tumor thrombus through hepatic vein, inferior vena cava into the right atrium.
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27816135/anesthesia-for-patients-with-concomitant-hepatic-and-pulmonary-dysfunction
#4
REVIEW
Geraldine C Diaz, Michael F O'Connor, John F Renz
Hepatic function and pulmonary function are interrelated with failure of one organ system affecting the other. With improved therapies, patients with concomitant hepatic and pulmonary failure increasingly enjoy a good quality of life and life expectancy. Therefore, the prevalence of such patients is increasing with more presenting for both emergent and elective surgical procedures. Hypoxemia requires a thorough evaluation in patients with end-stage liver disease. The most common etiologies respond to appropriate therapy...
December 2016: Anesthesiology Clinics
https://www.readbyqxmd.com/read/27777895/hypoxic-hepatitis-a-review-and-clinical-update
#5
REVIEW
Najeff Waseem, Po-Hung Chen
Hypoxic hepatitis (HH), also known as ischemic hepatitis or shock liver, is characterized by a massive, rapid rise in serum aminotransferases resulting from reduced oxygen delivery to the liver. The most common predisposing condition is cardiac failure, followed by circulatory failure as occurs in septic shock and respiratory failure. HH does, however, occur in the absence of a documented hypotensive event or shock state in 50% of patients. In intensive care units, the incidence of HH is near 2.5%, but has been reported as high as 10% in some studies...
September 28, 2016: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/27721918/implication-of-the-intestinal-microbiome-in-complications-of-cirrhosis
#6
Mamatha Bhat, Bianca M Arendt, Venkat Bhat, Eberhard L Renner, Atul Humar, Johane P Allard
The intestinal microbiome (IM) is altered in patients with cirrhosis, and emerging literature suggests that this impacts on the development of complications. The PubMed database was searched from January 2000 to May 2015 for studies and review articles on the composition, pathophysiologic effects and therapeutic modulation of the IM in cirrhosis. The following combination of relevant text words and MeSH terms were used, namely intestinal microbiome, microbiota, or dysbiosis, and cirrhosis, encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome, variceal bleeding, hepatopulmonary syndrome, portopulmonary hypertension and hepatocellular carcinoma...
September 28, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27720430/the-role-of-splenectomy-before-liver-transplantation-in-biliary-atresia-patients
#7
Yoshiaki Takahashi, Toshiharu Matsuura, Yusuke Yanagi, Koichiro Yoshimaru, Tomoaki Taguchi
BACKGROUND/PURPOSE: There is currently no unified view regarding whether liver transplantation or splenectomy should be performed for hypersplenism before liver transplantation in biliary atresia (BA) patients. We herein describe the efficacy of splenectomy before liver transplantation. METHODS: Splenectomy was performed in ten patients with hypersplenism associated with BA. We retrospectively reviewed their perioperative and postoperative courses, the number of leukocytes and thrombocytes, and the MELD score...
September 26, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27650268/biliary-atresia-indications-and-timing-of-liver-transplantation-and-optimization-of-pre-transplant-care
#8
Shikha S Sundaram, Cara L Mack, Amy G Feldman, Ronald J Sokol
Biliary Atresia is a progressive, fibro-obliterative disorder of the intra and extrahepatic bile ducts in infancy. The majority of affected children will eventually develop end-stage liver disease and require liver transplantation. Indications for liver transplant in biliary atresia include failed Kasai portoenterostomy, significant and recalcitrant malnutrition, recurrent cholangitis, and the progressive manifestations of portal hypertension. Extra-hepatic complications of this disease, such as hepatopulmonary syndrome and portopulmonary hypertension, are also indications for liver transplantation...
September 21, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27607172/hepatopulmonary-shunt-reduction-with-177lu-dotatate-therapy
#9
Emine Acar, Gamze Çapa Kaya, Hatice Durak
A 72-year-old man was diagnosed with well-differentiated neuroendocrine tumor of unknown primary with liver metastasis. All liver lesions were detectable only on Ga-DOTATATE PET/CT and were negative on F-FDG PET/CT. Intrahepatic Y radioembolization therapy was planned, but the hepatopulmonary shunt fraction was found to be 31.6%. Because the hepatopulmonary shunt fraction greater than 20% is an absolute contraindication to radioembolization, we decided to give him Lu-DOTATATE therapy. He received 4 courses of Lu-DOTATATE and showed regression in posttherapy Ga-DOTATATE PET/CT imaging...
November 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27594286/management-of-extra-hepatopulmonary-hydatid-cysts-157-cases
#10
Murat Çakır, Mehmet Balasar, Tevfik Küçükkartallar, Ahmet Tekin, Adil Kartal, Ömer Karahan, Süleyman Kargın
OBJECTIVE: Hydatid cyst disease (HCD) is a zoonotic infestation of Echinococcus granulosus, which is frequently seen in some regions of the world. Unusual localization of Echinococcus granulosus is very rare. Hence, we would like to present our experience of identifying an extra-hepatopulmonary location of hydatid cysts. METHODS: A total of 157 patients with an unusual location of hydatid cysts treated between 2000 and 2012 were retrospectively evaluated according to their age, sex, symptoms, diagnosis, stage, location of the cyst, and treatment modality...
December 0: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27580545/pulmonary-arterial-hypertension-associated-with-congenital-portosystemic-shunts-treated-with-transcatheter-embolization-and-pulmonary-vasodilators
#11
Haruka Sato, Masanobu Miura, Nobuhiro Yaoita, Saori Yamamoto, Shunsuke Tatebe, Tatsuo Aoki, Kimio Satoh, Hideki Ota, Kei Takase, Koichiro Sugimura, Hiroaki Shimokawa
Cardiopulmonary abnormalities are often present in patients with liver diseases. We herein report a case of congenital portosystemic shunts complicated by hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PoPH). A 57-year-old woman complained of dyspnea and was subsequently diagnosed with HPS and PoPH caused by congenital portosystemic shunts. Although shunt closure by transcatheter embolization was successfully performed, her dyspnea worsened and pulmonary artery pressure and pulmonary vascular resistance elevated...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27509319/microrna-196a2-rs11614913-c%C3%A2-%C3%A2-t-polymorphism-correlates-with-an-increased-risk-of-hepatopulmonary-syndrome-in-liver-cirrhosis-a-case-control-study-in-china
#12
Hai-Yong Chen, Yao-Min Chen, Jian Wu, Fu-Chun Yang, Zhen Lv, Xiao-Feng Xu, Shu-Sen Zheng, Sang-Sang Liao, Yi-Hui Luo
OBJECTIVE: This case-control study is designed to explore the relationship between microRNA-196a2 (miR-196a2) rs11614913 C > T polymorphism and the risk of hepatopulmonary syndrome (HPS) in liver cirrhosis METHODS: From January 2013 to January 2015, 163 liver cirrhosis patients with HPS (case group), 264 liver cirrhosis patients without HPS (control group) and 195 healthy people (normal group) were selected. DNA extraction Kit was used to extract plasma DNA from peripheral blood...
August 10, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27504083/very-early-presentation-of-extrahepatic-portal-vein-obstruction-causing-portal-hypertension-in-an-infant-uncertainties-in-the-management-and-therapeutic-limitations
#13
Parisá Khodayar-Pardo, Andrés Peña Aldea, Ana Ramírez González, Adela Meseguer Carrascosa, Cristina Calabuig Bayo
Extrahepatic portal vein obstruction, although rare in children, is a significant cause of portal hypertension (PHT) leading to life-threatening gastrointestinal bleeding in the pediatric age group. PHT may also lead to other complications such as hyperesplenism, cholangyopathy, ascites, and even hepatopulmonary syndrome and portopulmonary hypertension that may require organ transplantation. Herein we report the case of an asymptomatic 11-month-old infant wherein a hepatomegaly and cavernous transformation of the portal vein was detected by liver ultrasound...
May 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27484427/-a-man-with-slowly-progressive-dyspnea-on-exertion
#14
S T Lauren, S O Simons, A I J Arens
A 42-year-old man with a medical history of liver cirrhosis and portal hypertension was admitted to the hospital because of slowly progressive shortness of breath and hypoxemia. The diagnosis hepatopulmonary syndrome was confirmed by a pulmonary perfusion scan with 99m Tc-albumin. The scan showed a right-left shunt, because the 99m Tc-albumin transited the lungs and appeared in the brain, the thyroid gland, the kidneys and the spleen. The patient received a liver transplantation, which is considered the only definitive treatment...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27470899/-advances-in-diagnosis-and-treatment-of-hepatopulmonary-syndrome
#15
H Y Ma, X Li
Hepatopulmonary syndrome is a disease with abnormal gas exchange caused by liver diseases, with the feature of abnormal oxygenation caused by intrapulmonary vasodilation. This article introduces the pathogenesis, natural course, clinical manifestations, diagnostic methods, and therapeutic measures of this disease and discusses potential therapeutic measures besides liver transplantation.
May 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27468192/pulmonary-complications-of-hepatic-diseases
#16
REVIEW
Salim R Surani, Yamely Mendez, Humayun Anjum, Joseph Varon
Severe chronic liver disease (CLD) may result from portal hypertension, hepatocellular failure or the combination of both. Some of these patients may develop pulmonary complications independent from any pulmonary pathology that they may have. Among them the hepatopulmonary syndrome (HPS), portopulmonary hypertension (PPH) and hepatic hydrothorax (HH) are described in detail in this literature review. HPS is encountered in approximately 15% to 30% of the patients and its presence is associated with increase in mortality and also requires liver transplantation in many cases...
July 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27440733/hepatopulmonary-shunting-a-prognostic-indicator-of-survival-in-patients-with-metastatic-colorectal-adenocarcinoma-treated-with-90-y-radioembolization
#17
Kazim H Narsinh, Mark Van Buskirk, Andrew S Kennedy, Mohammed Suhail, Naif Alsaikhan, Carl K Hoh, Kenneth Thurston, Jeet Minocha, David S Ball, Steven J Cohen, Michael Cohn, Douglas M Coldwell, Alain Drooz, Eduardo Ehrenwald, Samir Kanani, Charles W Nutting, Fred M Moeslein, Michael A Savin, Sabine Schirm, Samuel G Putnam, Navesh K Sharma, Eric A Wang, Steven C Rose
: Purpose To determine if high lung shunt fraction (LSF) is an independent prognostic indicator of poor survival in patients who undergo yttrium 90 radioembolization for unresectable liver-dominant metastatic colorectal cancer. Materials and Methods Retrospective data were analyzed from 606 patients (62% men; mean age, 62 years) who underwent radioembolization to treat liver metastases from colorectal adenocarcinoma between July 2002 and December 2011 at 11 U.S. CENTERS: Institutional review board exemptions were granted prior to the collection of data at each site...
July 19, 2016: Radiology
https://www.readbyqxmd.com/read/27433178/acute-respiratory-failure-caused-by-hepatopulmonary-fistula-in-a-patient-with-hepatocellular-carcinoma
#18
Jungsil Lee, Yoon Jun Kim, Hyung-Jun Kim, Jee-Min Kim, Young-Chan Kim, Sun Mi Choi
A 59-year-old man presented with acute dyspnea following sudden productive cough and expectoration of a full cup of "blood-tinged" sputum. He had been diagnosed with hepatitis B virus-related hepatocellular carcinoma and had received transarterial chemoembolization 5 years ago for a 20-cm hepatic mass; he denied any history of hematemesis and the last esophagogastroduodenoscopy from a year ago showed absence of varix. Chest computed tomography (CT) with angiography showed new appearance of right basal lung consolidation but no bleeding focus...
July 2016: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27433086/hepatopulmonary-syndrome-what-we-know-and-what-we-would-like-to-know
#19
REVIEW
Israel Grilo-Bensusan, Juan Manuel Pascasio-Acevedo
Hepatopulmonary syndrome (HPS) is characterized by abnormalities in blood oxygenation caused by the presence of intrapulmonary vascular dilations (IPVD) in the context of liver disease, generally at a cirrhotic stage. Knowledge about the subject is still only partial. The majority of the information about the etiopathogenesis of HPS has been obtained through experiments on animals. Reported prevalence in patients who are candidates for a liver transplantation (LT) varies between 4% and 32%, with a predominance of mild or moderate cases...
July 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27392817/successful-long-term-outcome-of-liver-transplantation-in-late-onset-lysosomal-acid-lipase-deficiency
#20
S Sreekantam, I Nicklaus-Wollenteit, J Orr, K Sharif, S Vijay, P J McKiernan, S Santra
Late-onset LAL deficiency, previously referred to as cholesteryl ester storage disorder, is a rare lysosomal storage disorder characterized by accumulation of cholesteryl esters. It has a heterogeneous clinical phenotype including abdominal pain, poor growth, hyperlipidemia with vascular complications and hepatosplenomegaly. End-stage liver disease may occur, but there are few reports of successful LT. There are also concerns that systemic manifestations of the disease might persist post-LT. We report a case with excellent outcome eight yr following LT...
September 2016: Pediatric Transplantation
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