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https://www.readbyqxmd.com/read/27913229/a-single-arm-phase-iii-study-exploring-the-efficacy-and-safety-of-lng-ius-8-a-low-dose-levonorgestrel-intrauterine-contraceptive-system-total-content-13-5-mg-in-an-asia-pacific-population
#1
Guangsheng Fan, Sukho Kang, Mulan Ren, Edith Weisberg, Eeva Lukkari-Lax, Katrin Roth, SoYoung Shin
OBJECTIVE: To evaluate the efficacy and safety of a low-dose levonorgestrel intrauterine system with total content 13.5 mg (average approx. 8 μg/24 h over the first year; LNG-IUS 8; Jaydess®) in an Asia-Pacific population. STUDY DESIGN: An open-label, single-arm Phase III study conducted at 25 centers in China, Australia, and Korea assessed LNG-IUS 8 use over 3 years in nulliparous and parous women (N=1114) aged 18-40 years with regular menstrual cycles (21-35 days)...
November 29, 2016: Contraception
https://www.readbyqxmd.com/read/27898763/fine-mapping-of-resistance-genes-from-five-brown-stem-rot-resistance-sources-in-soybean
#2
Keith Rincker, Glen L Hartman, Brian W Diers
Brown stem rot (BSR) of soybean [ (L.) Merr.] caused by (Allington & Chamb.) T.C. Harr. & McNew can be controlled effectively with genetic host resistance. Three BSR resistance genes , , and , have been identified and mapped to a large region on chromosome 16. Marker-assisted selection (MAS) will be more efficient and gene cloning will be facilitated with a narrowed genomic interval containing an gene. The objective of this study was to fine map the positions of genes from five sources. Mapping populations were developed by crossing the resistant sources 'Bell', PI 84946-2, PI 437833, PI 437970, L84-5873, and PI 86150 with either the susceptible cultivar Colfax or Century 84...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27853310/non-coding-rnas-match-the-deleted-genomic-regions-in-humans
#3
Boseon Byeon, Igor Kovalchuk
RNA is transcribed from DNA, and therefore, there should be no RNA transcript from the deleted DNA region. Our study attempted to analyse whether any RNA cache that maps the deleted regions is present in human cells. Using data from the 1000 genome project, we selected 41 CEPH (CEU) and 38 Yoruba (YRI) samples that included the data for the entire genome sequence and ncRNA and mRNA sequences. Aligning the ncRNA reads against the genomic DNA in individual samples has revealed that 229 out of 1114 homozygous deletions have ncRNA reads that map to them...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27850751/1114-an-objective-measure-for-vai-predicts-mortality-in-pediatric-patients-not-treated-with-antibiotics
#4
Andrew Beardsley, Douglas Willson
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27780481/poultry-the-most-common-food-in-outbreaks-with-known-pathogens-united-states-1998-2012
#5
S J Chai, D Cole, A Nisler, B E Mahon
As poultry consumption continues to increase worldwide, and as the United States accounts for about one-third of all poultry exports globally, understanding factors leading to poultry-associated foodborne outbreaks in the United States has important implications for food safety. We analysed outbreaks reported to the United States' Foodborne Disease Outbreak Surveillance System from 1998 to 2012 in which the implicated food or ingredient could be assigned to one food category. Of 1114 outbreaks, poultry was associated with 279 (25%), accounting for the highest number of outbreaks, illnesses, and hospitalizations, and the second highest number of deaths...
October 26, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27681800/hospital-local-palliative-care-network-and-public-health-how-do-they-involve-terminally-ill-patients
#6
Gianlorenzo Scaccabarozzi, Fabrizio Limonta, Emanuele Amodio
BACKGROUND: Over one quarter of the health care expenditures is estimated to be spent for patients in the last year of life (LYL). For these patients, palliative care (PC) has been suggested as a response for improving the standards of care and reducing health costs. The aim of this study was to analyze a cohort of LYL people, in terms of comparing hospitalised patients who had been referred for PC to patients receiving usual care (UC). METHODS: Retrospective study carried out on patients resident in Lecco (Italy) who died between 2012 and 2013...
September 28, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/27671493/prognosis-of-stress-only-spect-myocardial-perfusion-imaging-with-prone-imaging
#7
Ariel Gutstein, Tamir Bental, Ajejandro Solodky, Israel Mats, Nili Zafrir
BACKGROUND: Stress-only single-photon emission computed tomography myocardial perfusion imaging (SO SPECT MPI) is associated with similarly benign prognosis as stress-rest SPECT MPI. However, previous studies have used attenuation correction rather than prone imaging to increase the rate of SO studies. OBJECTIVES: To assess the prognosis of SO SPECT MPI performed with prone imaging. METHODS: We performed a retrospective cohort analysis of all patients who underwent a Tc-99m gated SPECT MPI over a 58-month period...
September 26, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27658870/association-of-age-baseline-kidney-function-and-medication-exposure-with-declines-in-creatinine-clearance-on-pre-exposure-prophylaxis-an-observational-cohort-study
#8
Monica Gandhi, David V Glidden, Kenneth Mayer, Mauro Schechter, Susan Buchbinder, Beatriz Grinsztejn, Sybil Hosek, Martin Casapia, Juan Guanira, Linda-Gail Bekker, Alexander Louie, Howard Horng, Leslie Z Benet, Albert Liu, Robert M Grant
BACKGROUND: As pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine for the prevention of HIV infection is rolled out internationally, strategies to maintain effectiveness and to minimise adverse effects merit consideration. In this study, we aimed to assess reductions in renal function and predictors of renal toxicity in a large open-label study of PrEP. METHODS: As part of the iPrEx open-label extension (OLE) study, men who have sex with men or transgender women aged 18-70 years who were HIV negative and had participated in three previous PrEP trials from Brazil, Ecuador, Peru, South Africa, Thailand, and the USA were enrolled into an open-label PrEP study...
November 2016: Lancet HIV
https://www.readbyqxmd.com/read/27641950/identification-of-a-novel-mutation-in-hps6-in-a-patient-with-hemophilia-b-and-oculocutaneous-albinism
#9
Kevin J O'Brien, Jay Lozier, Andrew R Cullinane, Brigitte Osorio, Khanh Nghiem, Vladislav Speransky, Wadih M Zein, James C Mullikin, Anne T Neff, Karen L Simon, May Christine V Malicdan, William A Gahl, Lisa R Young, Bernadette R Gochuico
PURPOSE: Hemophilia B, an X-linked disease, manifests with recurrent soft tissue bleeding episodes. Hermansky-Pudlak syndrome, a rare autosomal recessive disorder, is characterized by oculocutaneous albinism and an increased tendency to bleed due to a platelet storage pool defect. We report a novel mutation in HPS6 in a Caucasian man with hemophilia B and oculocutaneous albinism. RESULTS: The patient was diagnosed with hemophilia B at age 4months due to recurrent soft tissue bleeding episodes, and he was also diagnosed with Hermansky-Pudlak syndrome at 32years of age due to unexplained oculocutaneous albinism...
November 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27628324/mash1-is-highly-specific-for-neuroendocrine-carcinomas-an-immunohistochemical-evaluation-on-normal-and-various-neoplastic-tissues
#10
David Altree-Tacha, Jillian Tyrrell, Faqian Li
Context .- High-grade neuroendocrine carcinomas and carcinoids can arise in different sites such as lung, gastrointestinal tract, prostate, and skin. Classic neuroendocrine markers such as CD56, synaptophysin, and chromogranin cannot distinguish carcinoids from high-grade neuroendocrine carcinomas. Recently, mouse monoclonal mASH1 has been shown to help discriminate carcinoids from high-grade neuroendocrine carcinomas in various neoplastic sites. To date, there have been no comprehensive immunohistochemistry studies with mASH1 on nonneuroendocrine neoplasms...
September 15, 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27606428/the-active-metabolite-of-warfarin-3-hydroxywarfarin-and-correlation-with-inr-warfarin-and-drug-weekly-dosage-in-patients-under-oral-anticoagulant-therapy-a-pharmacogenetics-study
#11
Donato Gemmati, Francesco Burini, Anna Talarico, Matteo Fabbri, Cesare Bertocco, Marco Vigliano, Stefano Moratelli, Antonio Cuneo, Maria Luisa Serino, Francesco Maria Avato, Veronica Tisato, Rosa Maria Gaudio
OBJECTIVES: Warfarin oral anticoagulant therapy (OAT) requires regular and frequent drug adjustment monitored by INR. Interindividual variability, drug and diet interferences, and genetics (VKORC1 and CYP2C9) make the maintenance/reaching of stable INR a not so easy task. HPLC assessment of warfarin/enantiomers was suggested as a valid monitoring-tool along with INR, but definite results are still lacking. We evaluated possible correlations between INR, warfarin/3'-hydroxywarfarin, and drug weekly dosage aimed at searching novel alternatives to OAT monitoring...
2016: PloS One
https://www.readbyqxmd.com/read/27602974/econazole-nitrate-foam-1-improves-the-itch-of-tinea-pedis
#12
Alan B Fleischer, Isabelle Raymond
Econazole nitrate topical foam, 1%, is indicated for the treatment of interdigital tinea pedis caused by <em>Trichophyton rubrum, Trichophyton mentagrophytes,</em> and <em>Epidermophyton floccosum</em> in patients 12 years of age and older. The symptom of itch or pruritus was evaluated in two randomized, double-blind, parallel-group, vehicle-controlled, multicenter Phase III studies in which econazole foam was compared with foam vehicle in subjects with interdigital tinea pedis. A thin, uniform layer of study treatment was applied once daily to all clinically affected interdigital regions of both feet for four weeks...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27589022/uhplc-esi-ms-ms-for-the-quantification-of-eight-major-gingerols-and-shogaols-in-ginger-products-effects-of-ionization-polarity-and-mobile-phase-modifier-on-the-sensitivity
#13
Su Yeon Park, Mun Yhung Jung
We developed and validated an improved ultra high performance liquid chromatography (UHPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) method for the fast separation and quantification of 8 major gingerols and shogaols (4-, 6-, 8-, 10-, and 12-gingerols, and 6-, 8-, and 10-shogaols) in gingerol products. The ionization polarity and mobile phase modifier greatly affected the mass ion profiles and sensitivity of the analytes. A mobile phase modifier of 0.05 mM ammonium formate dramatically decreased the sodium adduct ions and greatly increased the protonated ions of the gingerols and shogaols...
October 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27584270/metabolic-and-performance-responses-to-repeated-sprint-exercise-in-hypoxia-in-female-athletes-1114-board-3-june-1-3-15-pm-5-15-pm
#14
Nobukazu Kasai, Chihiro Kojima, Kazushige Goto
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27544525/fine-mapping-of-the-rsv1-h-gene-in-the-soybean-cultivar-suweon-97-that-confers-resistance-to-two-chinese-strains-of-the-soybean-mosaic-virus
#15
Fang-Fang Ma, Xiao-Yi Wu, Yun-Xia Chen, Ying-Na Liu, Zhu-Qing Shao, Ping Wu, Mian Wu, Cheng-Chen Liu, Wen-Ping Wu, Jia-Yin Yang, De-Xiao Li, Jian-Qun Chen, Bin Wang
The Rsv1 - h gene in cultivar Suweon 97, which confers resistance to SMVs, was mapped to a 97.5-kb location (29,815,195-29,912,667 bp on chromosome 13) in the Rsv1 locus, thereby providing additional insights into the molecular nature underlying variations in resistance alleles in this particular locus. Soybean mosaic virus (SMV) is a well-known devastating pathogen of soybean (Glycine max (L.) Merrill.) causing significant yield losses and seed quality deterioration. A single dominant allele, Rsv1-h, which confers resistance to multiple SMV strains, was previously reported in the cultivar Suweon 97, but its exact location is unknown...
August 20, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27505299/synthetic-utilization-of-%C3%AE-aminoalkyl-radicals-and-related-species-in-visible-light-photoredox-catalysis
#16
Kazunari Nakajima, Yoshihiro Miyake, Yoshiaki Nishibayashi
Single electron oxidation of amines provides an efficient way to access synthetically useful α-aminoalkyl radicals as reactive intermediates. After the single electron oxidation of amines, fragmentation of the resulting radical cations proceeds to give the α-aminoalkyl radicals along with generation of a proton. In the synthetic utilization of the α-aminoalkyl radicals, precise control of single electron transfer is essential, because further oxidation of the α-aminoalkyl radicals occurs more easily than the starting amines and the α-aminoalkyl radicals are converted into the corresponding iminium ions...
September 20, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27498913/monogenic-and-polygenic-determinants-of-sarcoma-risk-an-international-genetic-study
#17
Mandy L Ballinger, David L Goode, Isabelle Ray-Coquard, Paul A James, Gillian Mitchell, Eveline Niedermayr, Ajay Puri, Joshua D Schiffman, Gillian S Dite, Arcadi Cipponi, Robert G Maki, Andrew S Brohl, Ola Myklebost, Eva W Stratford, Susanne Lorenz, Sung-Min Ahn, Jin-Hee Ahn, Jeong Eun Kim, Sue Shanley, Victoria Beshay, Robert Lor Randall, Ian Judson, Beatrice Seddon, Ian G Campbell, Mary-Anne Young, Rajiv Sarin, Jean-Yves Blay, Seán I O'Donoghue, David M Thomas
BACKGROUND: Sarcomas are rare, phenotypically heterogeneous cancers that disproportionately affect the young. Outside rare syndromes, the nature, extent, and clinical significance of their genetic origins are not known. We aimed to investigate the genetic basis for bone and soft-tissue sarcoma seen in routine clinical practice. METHODS: In this genetic study, we included 1162 patients with sarcoma from four cohorts (the International Sarcoma Kindred Study [ISKS], 966 probands; Project GENESIS, 48 probands; Asan Bio-Resource Center, 138 probands; and kConFab, ten probands), who were older than 15 years at the time of consent and had a histologically confirmed diagnosis of sarcoma, recruited from specialist sarcoma clinics without regard to family history...
September 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27488698/growth-hormone-co-treatment-within-a-gnrh-agonist-long-protocol-improves-implantation-and-pregnancy-rates-in-patients-undergoing-ivf-et
#18
Xiao-Fang Du, Xin-Hong Yang, Jing Li, Mengmeng Hao, Yi-Hong Guo
OBJECTIVE: The efficacy of growth hormone (GH) co-treatment within a GnRH agonist long regimen, in women with a normal ovarian response to controlled ovarian hyperstimulation (COH), for IVF was assessed. METHODS: This retrospective clinical trial was performed in a private-assisted reproduction centre. The study involved 1114 patients who responded normally to high-dose gonadotropin treatment. The study group of 556 patients was given in a daily subcutaneous injection of 4...
October 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27473366/the-role-of-circulating-thrombospondin-1-in-patients-with-precapillary-pulmonary-hypertension
#19
Ralf Kaiser, Christian Frantz, Robert Bals, Heinrike Wilkens
BACKGROUND: The vasoconstrictive protein TSP-1 is released from endothelial cells upon increased shear stress and hypoxia. Both conditions are prevalent in pulmonary hypertension (PH). TSP-1 damages the local microcirculation by disrupting pathways, which are essential for specific medical therapeutics. Furthermore, TSP-1 induces excessive fibrosis and smooth muscle proliferation - a common finding in advanced PH - via TGF-ß and might promote disease progression. The prognostic impact of circulating TSP-1, influence on hemodynamic parameters and interaction with other biomarkers in patients with PH is incompletely understood...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27470154/gambling-and-problem-gambling-among-canadian-urban-aboriginals
#20
Robert J Williams, Yale D Belanger, S Yvonne Prusak
OBJECTIVE: To assess the prevalence of gambling and problem gambling in urban Aboriginals in the Canadian Prairie provinces and to determine the predictors of problem gambling. METHOD: In total, 1114 Aboriginals living in 15 cities in Alberta, Saskatchewan, and Manitoba were recruited via posters and direct solicitation at Native Friendship Centres, shopping malls, and other locations where Aboriginals congregated. They each completed a self-administered 5- to 10-minute survey...
November 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
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