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https://www.readbyqxmd.com/read/29240922/prevalence-magnitude-and-correlates-of-hiv-1-genital-shedding-in-women-on-antiretroviral-therapy
#1
Caroline C King, Sascha R Ellington, Nicole L Davis, Robert W Coombs, Maria Pyra, Ting Hong, Nelly Mugo, Rena C Patel, Jairam R Lingappa, Jared M Baeten, Athena P Kourtis
Background: Genital human immunodeficiency virus (HIV) RNA shedding can continue despite HIV being undetectable in blood, and can be associated with transmission. Methods: We included African women on antiretroviral therapy (ART). Linear and generalized linear mixed models were used to compare the magnitude and prevalence of genital shedding, respectively, by time since ART initiation. Multivariable logistic regression with generalized estimating equations was used to assess predictors of genital shedding among women with undetectable plasma viral load (VL)...
December 12, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29239711/interval-breast-cancer-rates-and-histopathologic-tumor-characteristics-after-false-positive-findings-at-mammography-in-a-population-based-screening-program
#2
Solveig Hofvind, Silje Sagstad, Sofie Sebuødegård, Ying Chen, Marta Roman, Christoph I Lee
Purpose To compare rates and tumor characteristics of interval breast cancers (IBCs) detected after a negative versus false-positive screening among women participating in the Norwegian Breast Cancer Screening Program. Materials and Methods The Cancer Registry Regulation approved this retrospective study. Information about 423 445 women aged 49-71 years who underwent 789 481 full-field digital mammographic screening examinations during 2004-2012 was extracted from the Cancer Registry of Norway. Rates and odds ratios of IBC among women with a negative (the reference group) versus a false-positive screening were estimated by using logistic regression models adjusted for age at diagnosis and county of residence...
December 14, 2017: Radiology
https://www.readbyqxmd.com/read/29227273/-poisoning-by-psychopharmacological-drugs-in-azerbaijan-the-results-of-8-year-prospective-observation
#3
I Afandiyev, V Azizov
Acute poisoning of chemical etiology is a significant global public health problem. The aim of this study was the analysis of the toxicoepidemiological structure of psychopharmacological drugs poisoning in Azerbaijan. We collected and analyzed the data on all cases of acute poisoning by psychopharmacological drugs (codes of categories T42/T43 ICD-10) undergoing inpatient treatment at the Center of Clinical Toxicology in Baku, Azerbaijan in 2009-2016. The total number of patients with acute intoxication by psychopharmacological drugs was 3,413, which was 48...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29208861/etiology-of-early-renal-allograft-dysfunction-and-comparison-between-dysfunction-and-function-group-a-single-center-study
#4
K M Hadiuzzaman, S F Islam, M O Faroque, R M Hossain, M Munirunnessa, S I Selim, M Morshed
Over a period of two years thirty five renal allograft recipients & donors were evaluated to find out the aetiology of early renal allograft dysfunction, in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from March 2010 to February 2012. A comparison was made between dysfunction & functioning graft group. Mean age of recipients were (36.4±9.4) years, mean age of donors were (41.7±8.3) years, with a male and female ratio of 3:1. Fifty percent recipients showed one heliotype match, ninety percent recipients were anti CMV antibody IgG positive, few were anti CMV antibody IgM positive...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29148842/erratum
#5
(no author information available yet)
Yao H, Lu H, Zhao H, et al. Open reduction assisted with an external fixator and internal fixation with calcaneal locking plate for intra-articular calcaneal fractures. Foot Ankle Int. 2017;38(10):1107-1114. (Original DOI: 10.1177/1071100717715908) The above article appeared with the incorrect corresponding author. The correct corresponding author is Huading Lu, PhD. The corrected corresponding author information is below: Corresponding Author: Huading Lu, PhD, Department of Orthopaedics, The Fifth Affiliated Hospital of Sun Yat-sen University, NO...
November 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29134925/effects-of-ssri-exposure-on-hemorrhagic-complications-and-outcome-following-thrombolysis-in-ischemic-stroke
#6
Schellen Christoph, Ferrari Julia, Lang Wilfried, Sykora Marek
Background Selective serotonin reuptake inhibitors (SSRI) may interfere with platelet function, and pre-stroke SSRI treatment has been associated with increased hematoma volumes and mortality in hemorrhagic stroke patients. The effects of SSRI on the risk of hemorrhagic complications after thrombolysis in ischemic stroke patients are unclear. Aims To examine the effects of pre-stroke SSRI exposure on bleeding complications, functional outcome, and mortality following thrombolysis in ischemic stroke. Methods Data including standard demographic and clinical variables as well as baseline and follow-up stroke severity (measured by National Institutes of Health Stroke Score), functional outcome (measured by modified Rankin Scale) at 3 months, and mortality at 7 and 90 days were extracted from the Virtual International Stroke Trials Archive...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29107379/engineered-designer-biochar-for-the-removal-of-phosphate-in-water-and-wastewater
#7
Kumar Vikrant, Ki-Hyun Kim, Yong Sik Ok, Daniel C W Tsang, Yiu Fai Tsang, Balendu Shekhar Giri, Ram Sharan Singh
During the past decade, biochar has attracted immense scientific interest for agricultural and environmental applications. A broad range of biochars with advantageous properties (e.g., high surface area, flexible architecture, and high porosity) has been developed for pollution abatement. Nevertheless, biochar suffers from certain drawbacks (e.g., limited sorption capacity for anions and poor mechanical properties) that limit their practical applicability. This review focuses on recent advancements in biochar technology, especially with respect to its technical aspects, the variables associated with removing phosphates from water, and the challenges for such abatement...
October 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29092921/contrast-induced-acute-kidney-injury-and-mortality-in-st-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#8
Johanne Silvain, Lee S Nguyen, Vincent Spagnoli, Mathieu Kerneis, Paul Guedeney, Nicolas Vignolles, Kristel Cosker, Olivier Barthelemy, Claude Le Feuvre, Gérard Helft, Jean-Philippe Collet, Gilles Montalescot
OBJECTIVES: Contrast-induced acute kidney injury (CI-AKI) is a common and potentially severe complication in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). There is no consensus on the best definition of CI-AKI to identify patients at risk of haemodialysis or death. The objective of this study was to assess the association of CI-AKI, using four definitions, on inhospital mortality, mortality or haemodialysis requirement over 1-year follow-up, in patients with STEMI treated with pPCI...
November 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29092898/patient-preference-and-choice-of-healthcare-providers-in-shanghai-china-a-cross-sectional-study
#9
Wenya Yu, Meina Li, Feng Ye, Chen Xue, Lulu Zhang
OBJECTIVES: This study aimed to assess patients' healthcare-seeking preferences in mild, chronic, and serious illness; identify influential factors; and examine the reasons underlying patients' healthcare-seeking preference. DESIGN: A retrospective study. SETTING: The study was conducted in 14 tertiary hospitals in Shanghai, China. PARTICIPANTS: Questionnaires were distributed to 1519 patients, and 1114 were completed and returned...
November 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/29076974/on-the-role-of-illness-duration-and-nutrient-restriction-in-cholestatic-alterations-that-occur-during-critical-illness
#10
Marc Jenniskens, Fabian Güiza, Marlies Oorts, Sarah Vander Perre, Sarah Derde, Thomas Dufour, Steven Thiessen, Pieter Annaert, Greet Van den Berghe, Lies Langouche
BACKGROUND AND AIMS: Elevated markers of cholestasis are common in response to critical illness, and associated with adverse outcome. The role of illness duration and of nutrient restriction on underlying molecular pathways of such cholestatic responses have not been thoroughly investigated. METHODS: In a mouse model of surgery- and sepsis-induced critical illness, molecular pathways of cholestasis were investigated up to 7 days. To assess which changes are explained by illness-induced lack of feeding, nutrient-restricted healthy mice were studied and compared with ad libitum fed healthy mice...
October 25, 2017: Shock
https://www.readbyqxmd.com/read/29048369/effect-of-curcumin-on-the-diversity-of-gut-microbiota-in-ovariectomized-rats
#11
Zhiguo Zhang, Yanjing Chen, Lihua Xiang, Zhen Wang, Gary Guishan Xiao, Jingqing Hu
Curcumin has been proven to have a weight-loss effect in a menopausal rat model induced by ovariectomy. However, the effects of curcumin on gut microfloral communities of ovariectomized (OVX) rats remains unclear. Here, we used high-throughput 16S rDNA sequencing to explore the effects of curcumin on microbial diversity in the gut of OVX rats. Female Wistar rats were subjected to either ovariectomy or a sham operation (SHAM group). The OVX rats were treated with vehicle (OVX group) or curcumin (CUR group) by oral gavage...
October 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28992258/risk-and-complications-of-venous-thromboembolism-in-dialysis-patients
#12
Amber O Molnar, Sarah E Bota, Eric McArthur, Ngan N Lam, Amit X Garg, Ron Wald, Deborah Zimmerman, Manish M Sood
Background: Contemporary data on venous thromboembolism (VTE) risk in dialysis patients are limited. Our objective was to determine the risk and complications of VTE among incident maintenance dialysis patients. Methods: We performed a retrospective cohort study using administrative databases. We included adult incident dialysis patients from 2004 to 2010 ( n  = 13 315). Dialysis patients were age- and sex-matched to individuals of the general population using a 1:4 ratio ( n  = 53 260)...
July 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28968138/safety-immunogenicity-and-lot-to-lot-consistency-of-a-split-virion-quadrivalent-influenza-vaccine-in-younger-and-older-adults-a-phase-iii-randomized-double-blind-clinical-trial
#13
Sanie Sesay, Jerzy Brzostek, Ingo Meyer, Yves Donazzolo, Geert Leroux-Roels, Régine Rouzier, Béatrice Astruc, Henryk Szymanski, Nicole Toursarkissian, Corinne Vandermeulen, Edyta Kowalska, Pierre Van Damme, Camille Salamand, Stephanie Pepin
Here, we report a randomized multicenter phase III trial assessing the lot-to-lot consistency of the 2014-2015 Northern Hemisphere quadrivalent split-virion inactivated influenza vaccine (IIV4; Sanofi Pasteur) and comparing its immunogenicity and safety with that of trivalent inactivated influenza vaccine (IIV3) in younger and older adults (EudraCT no. 2014-000785-21). Younger (18-60 y, n = 1114) and older (>60 y, n = 1111) adults were randomized 2:2:2:1:1 to receive a single dose of one of three lots of IIV4, the licensed IIV3 containing the B Yamagata lineage strain, or an investigational IIV3 containing the B Victoria lineage strain...
October 2, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28965233/prediction-of-liver-toxicity-and-mode-of-action-using-metabolomics-in-vitro-in-hepg2-cells
#14
Tzutzuy Ramirez, Alexander Strigun, Andreas Verlohner, Hans-Albrecht Huener, Erik Peter, Michael Herold, Natalie Bordag, Werner Mellert, Tilmann Walk, Michael Spitzer, Xiaoqi Jiang, Saskia Sperber, Thomas Hofmann, Thomas Hartung, Hennicke Kamp, Ben van Ravenzwaay
Liver toxicity is a leading systemic toxicity of drugs and chemicals demanding more human-relevant, high throughput, cost effective in vitro solutions. In addition to contributing to animal welfare, in vitro techniques facilitate exploring and understanding the molecular mechanisms underlying toxicity. New 'omics technologies can provide comprehensive information on the toxicological mode of action of compounds, as well as quantitative information about the multi-parametric metabolic response of cellular systems in normal and patho-physiological conditions...
September 30, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28951961/a-16-7%C3%A2-kb-deletion-in-sipa1l3-is-associated-with-juvenile-cataract-in-mice
#15
Lianna R Walker, Emily R Tosky, Kylee M Sutton, Rhonda Griess, Marytza D Abebe, Sarah Y Barnes, Tom Cunnigham, Stephen D Kachman, Merlyn K Nielsen, Daniel C Ciobanu
Congenital or juvenile cataract is a disease condition in which opacification of the lenses is present at birth or manifests early in life. It has been attributed to different monogenic factors with a high degree of heterogeneity and is often studied using mouse models. A spontaneous mutation was identified in a mouse line selected for heat loss that influenced lens formation and resulted in juvenile cataracts in mice homozygous for the recessive allele. Genetic dissection of this selection line by combining high-density genotypes and homozygosity mapping uncovered a 906 kb fragment on MMU7 encompassing 21 SNPs split into two groups of consecutive, homozygous segments specific to the cataract phenotype...
December 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28949373/-corrigendum-suppression-of-cul4a-attenuates-tgf-%C3%AE-1-induced-epithelial-to-mesenchymal-transition-in-breast-cancer-cells
#16
Yunshan Wang, Xiaoyan Liu, Hui Zheng, Qin Wang, Li An, Guangwei Wei
Following the publication of this article, a reader drew to our attention an anomaly associated with the data presented in Fig. 8. The reader found that the two images of the Control group treated with TGF-β1 in Fig. 8 have some overlap. After careful scrutiny, we found that we somehow misused a migation image for invasion (lower pannel) when constructing the final figure. This does not affect the interpretation of the experiments and the conclusions of the study. A corrected version of Fig. 8 is presented here...
September 14, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28904920/antimicrobial-susceptibility-pattern-of-extended-spectrum-beta-lactamases-producing-organisms-isolated-in-a-tertiary-care-hospital-bangladesh
#17
Mohammad Jobayer, Zeenat Afroz, Sultana Shazeda Nahar, Ayesha Begum, Shahin Ara Begum, S M Shamsuzzaman
CONTEXT: Infection caused by extended-spectrum beta-lactamases (ESBL) producing organism is a major problem regarding antibiotic resistance. AIMS: The aim of this study was to find out the antibiogram of ESBL producing organisms isolated from various samples. SETTINGS AND DESIGN: This cross-sectional study was carried out in the Department of Microbiology of a Tertiary Care Hospital, Dhaka, Bangladesh from January to June 2014. SUBJECTS AND METHODS: One Hundred and seventy-nine ESBL producing Gram-negative organisms detected phenotypically by double-disc synergy test were enrolled in this study...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28892506/does-progestin-only-contraceptive-use-after-pregnancy-affect-recovery-from-pelvic-girdle-pain-a-prospective-population-study
#18
Elisabeth Krefting Bjelland, Katrine Mari Owe, Hedvig Marie Egeland Nordeng, Bo Lars Engdahl, Per Kristiansson, Siri Vangen, Malin Eberhard-Gran
OBJECTIVE: To estimate associations of progestin-only contraceptives with persistent pelvic girdle pain 18 months after delivery. METHODS: Prospective population based cohort study during the years 2003-2011. We included 20,493 women enrolled in the Norwegian Mother and Child Cohort Study who reported pelvic girdle pain in pregnancy week 30. Data were obtained by 3 self-administered questionnaires and the exposure was obtained by linkage to the Prescription Database of Norway...
2017: PloS One
https://www.readbyqxmd.com/read/28855755/comparison-of-apical-debris-extrusion-during-root-canal-preparation-using-instrumentation-techniques-with-two-operating-principles-an-in-vitro-study
#19
Mudita Verma, N Meena, R Anitha Kumari, Sudhanva Mallandur, R Vikram, Vishwas Gowda
AIMS: The aim of this study was to quantify the debris extruded apically from teeth using rotary and reciprocation instrumentation systems. SUBJECTS AND METHODS: Eighty extracted human mandibular premolars with single canals and similar lengths were instrumented using ProTaper Universal (40, 06; Dentsply Maillefer, Ballaigues, Switzerland), ProTaper Next (40, 06; Dentsply Maillefer, Ballaigues, Switzerland), WaveOne (40, 06; Dentsply Maillefer, Ballaigues, Switzerland), and Reciproc (R40; VDW GmbH, Munich, Germany)...
March 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/28798726/systems-biology-analysis-of-temporal-in-vivo-brucella-melitensis-and-bovine-transcriptomes-predicts-host-pathogen-protein-protein-interactions
#20
Carlos A Rossetti, Kenneth L Drake, Sara D Lawhon, Jairo S Nunes, Tamara Gull, Sangeeta Khare, Leslie G Adams
To date, fewer than 200 gene-products have been identified as Brucella virulence factors, and most were characterized individually without considering how they are temporally and coordinately expressed or secreted during the infection process. Here, we describe and analyze the in vivo temporal transcriptional profile of Brucella melitensis during the initial 4 h interaction with cattle. Pathway analysis revealed an activation of the "Two component system" providing evidence that the in vivo Brucella sense and actively regulate their metabolism through the transition to an intracellular lifestyle...
2017: Frontiers in Microbiology
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