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https://www.readbyqxmd.com/read/28798726/systems-biology-analysis-of-temporal-in-vivo-brucella-melitensis-and-bovine-transcriptomes-predicts-host-pathogen-protein-protein-interactions
#1
Carlos A Rossetti, Kenneth L Drake, Sara D Lawhon, Jairo S Nunes, Tamara Gull, Sangeeta Khare, Leslie G Adams
To date, fewer than 200 gene-products have been identified as Brucella virulence factors, and most were characterized individually without considering how they are temporally and coordinately expressed or secreted during the infection process. Here, we describe and analyze the in vivo temporal transcriptional profile of Brucella melitensis during the initial 4 h interaction with cattle. Pathway analysis revealed an activation of the "Two component system" providing evidence that the in vivo Brucella sense and actively regulate their metabolism through the transition to an intracellular lifestyle...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28758518/allometric-scaling-of-power-force-velocity-ergometry-profiles-in-men
#2
Hamdi Jaafar
AIM: To examine the appropriate magnitude of allometric scaling of the force-velocity relationship according to body dimensions and to establish normative data for the power-force-velocity relationship for active men. SUBJECTS AND METHODS: Ninety-seven participants completed a force-velocity test on a Monark cycle ergometer. Allometric exponents and percentile ranks were established for maximal power (Pmax), maximal force (F0) and maximal velocity (V0). RESULTS: The mean (± SD) of Pmax, F0 and V0 were 1114...
July 31, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/28753391/differences-in-forearm-strength-endurance-and-hemodynamic-kinetics-between-male-boulderers-and-lead-rock-climbers
#3
S Fryer, K J Stone, J Sveen, T Dickson, V España-Romero, D Giles, J Baláš, L Stoner, N Draper
This study examined differences in the oxygenation kinetics and strength and endurance characteristics of boulderers and lead sport climbers. Using near infrared spectroscopy, 13-boulderers, 10-lead climbers, and 10-controls completed assessments of oxidative capacity index and muscle oxygen consumption (mV˙O2) in the flexor digitorum profundus (FDP), and extensor digitorum communis (EDC). Additionally, forearm strength (maximal volitional contraction MVC), endurance (force-time integral FTI at 40% MVC), and forearm volume (FAV and ΔFAV) was assessed...
July 28, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28746323/ocular-morbidity-among-children-of-government-schools-of-kathmandu-valley-a-follow-up-study
#4
R K Shrestha, G S Shrestha
INTRODUCTION: Ocular and vision defects are common among school going children. Vision disorders, especially refractive errors are the main disabilities of children and the leading cause of handicapping conditions of childhood. The present study was conducted to find out ocular morbidity among students of government schools of Kathmandu valley. METHODS: In the descriptive and cross-sectional study, 2412 students, comprising of 1114 (46.2%) males and 1298 (53.8%) females were enrolled in to the study from the five government schools of Kathmandu valley from 2012 to 2013...
April 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28662110/back-pain-in-elite-sports-a-cross-sectional-study-on-1114-athletes
#5
Daniela Fett, Katharina Trompeter, Petra Platen
OBJECTIVES: To establish the prevalence of back pain in German elite athletes; examine the influence of age, sex, sports discipline and training volume; and compare elite athletes with a physically active control group. METHODS: A standardized and validated online back pain questionnaire was sent by the German Olympic Sports Confederation to approximately 4,000 German national and international elite athletes, and a control group of 253 physically active but non-elite sports students...
2017: PloS One
https://www.readbyqxmd.com/read/28651296/early-discharge-hospital-at-home
#6
REVIEW
Daniela C Gonçalves-Bradley, Steve Iliffe, Helen A Doll, Joanna Broad, John Gladman, Peter Langhorne, Suzanne H Richards, Sasha Shepperd
BACKGROUND: Early discharge hospital at home is a service that provides active treatment by healthcare professionals in the patient's home for a condition that otherwise would require acute hospital inpatient care. This is an update of a Cochrane review. OBJECTIVES: To determine the effectiveness and cost of managing patients with early discharge hospital at home compared with inpatient hospital care. SEARCH METHODS: We searched the following databases to 9 January 2017: the Cochrane Effective Practice and Organisation of Care Group (EPOC) register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, and EconLit...
June 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28648882/transcriptome-analysis-of-the-hepatopancreas-in-exopalaemon-carinicauda-infected-with-an-ahpnd-causing-strain-of-vibrio-parahaemolyticus
#7
Qianqian Ge, Jian Li, Jiajia Wang, Jitao Li, Hongxing Ge, Qianqian Zhai
Acute hepatopancreatic necrosis disease (AHPND) caused by Vibrio parahaemolyticus carrying toxin-producing plasmid, has led to severe mortalities in multiple shrimp species throughout Asia. In order to understand the immunological response of shrimp to infection by AHPND-causing strain of V. parahaemolyticus (VPAHPND), the transcriptomic profiles of the hepatopancreas from severe AHPND-infected (BS_G), AHPND-survived (KB_G) and non-infected (PBS_G) Exopalaemon carinicauda groups were obtained using HiSeq™ 2500 (Illumina)...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28644012/sigma-2-receptor-tmem97-agonists-produce-long-lasting-antineuropathic-pain-effects-in-mice
#8
James J Sahn, Galo L Mejia, Pradipta R Ray, Stephen F Martin, Theodore J Price
Neuropathic pain is an important medical problem with few effective treatments. The sigma 1 receptor (σ1R) is known to be a potential target for neuropathic pain therapeutics, and antagonists for this receptor are effective in preclinical models and are currently in phase II clinical trials. Conversely, relatively little is known about σ2R, which has recently been identified as transmembrane protein 97 (Tmem97). We generated a series of σ1R and σ2R/Tmem97 agonists and antagonists and tested them for efficacy in the mouse spared nerve injury (SNI) model...
August 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28627725/proteomic-analysis-of-host-cell-protein-dynamics-in-the-supernatant-of-fc-fusion-protein-producing-cho-dg44-and-dukx-b11-cell-lines-in-batch-and-fed-batch-cultures
#9
Jin Hyoung Park, Jong Hwa Jin, In Jung Ji, Hyun Joo An, Jong Won Kim, Gyun Min Lee
Chinese hamster ovary (CHO) cells are the most widely used host cell lines for the commercial production of therapeutic proteins including Fc-fusion proteins. During the culture of recombinant CHO (rCHO) cells, host cell proteins (HCPs), secreted from viable cells and released from dead cells, accumulate extracellularly, potentially impairing product quality. In this study, the HCPs that accumulated extracellularly in batch and fed-batch cultures of Fc-fusion protein-producing rCHO cell lines (DG-Fc and DUKX-Fc) were identified and quantified using nanoflow liquid chromatography-tandem mass spectrometry (LC-MS/MS), followed by gene ontology and functional analysis...
June 19, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28623596/impact-of-residency-training-level-on-the-surgical-quality-following-general-surgery-procedures
#10
Dominik Loiero, Maja Slankamenac, Pierre-Alain Clavien, Ksenija Slankamenac
OBJECTIVE: To investigate the safety of surgical performance by residents of different training level performing common general surgical procedures. METHODS: Data were consecutively collected from all patients undergoing general surgical procedures such as laparoscopic cholecystectomy, laparoscopic appendectomy, inguinal, femoral and umbilical hernia repair from 2005 to 2011 at the Department of Surgery of the University Hospital of Zurich, Switzerland. The operating surgeons were grouped into junior residents, senior residents and consultants...
June 16, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28618777/rare-earth-pcu-metal-organic-framework-platform-based-on-re4-%C3%AE-3-oh-4-coo-6-2-clusters-rational-design-directed-synthesis-and-deliberate-tuning-of-excitation-wavelengths
#11
Tian-Yi Luo, Chong Liu, Svetlana V Eliseeva, Patrick F Muldoon, Stéphane Petoud, Nathaniel L Rosi
The Td point group symmetry of rare earth (RE(3+)) metal clusters RE4(μ3-OH)4(COO)6(2+) makes them attractive building blocks for creating metal-organic frameworks (MOFs) with controllable topologies. Herein, we describe the design and synthesis of a series of isoreticular MOFs featuring pcu topology [MOF-1114(RE) and MOF-1115(RE)] with variable rare earth metal ions (RE(3+) = Y(3+), Sm(3+), Eu(3+), Gd(3+), Tb(3+), Dy(3+), Ho(3+), Er(3+), Tm(3+), Yb(3+)) and linear amino-functionalized dicarboxylate linkers of different lengths...
June 30, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28595343/sequencing-de-novo-assembling-and-annotating-the-genome-of-the-endangered-chinese-crocodile-lizard-shinisaurus-crocodilurus
#12
Jian Gao, Qiye Li, Zongji Wang, Yang Zhou, Paolo Martelli, Fang Li, Zijun Xiong, Jian Wang, Huanming Yang, Guojie Zhang
The Chinese crocodile lizard, Shinisaurus crocodilurus, is the only living representative of the monotypic family Shinisauridae under the order Squamata. It is an obligate semi-aquatic, viviparous, diurnal species restricted to specific portions of mountainous locations in southwestern China and northeastern Vietnam. However, in the past several decades, this species has undergone a rapid decrease in population size due to illegal poaching and habitat disruption, making this unique reptile species endangered and listed in CITES Appendix II since 1990...
June 8, 2017: GigaScience
https://www.readbyqxmd.com/read/28587952/the-effect-of-trimetazidine-treatment-in-patients-with-type-2-diabetes-undergoing-percutaneous-coronary-intervention-for-acute-myocardial-infarction
#13
Runjun Li, Xiuying Tang, Quanmin Jing, Qingsheng Wang, Meihong Yang, Xiaoyu Han, Jiayu Zhao, Xiangyou Yu
PURPOSE: Trimetazidine (TMZ) improves clinical outcomes in patients with chronic heart failure and stable coronary artery disease. No study has yet evaluated the efficacy of TMZ in type 2 diabetes patients with acute myocardial infarction (AMI) undergoing Percutaneous Coronary Intervention (PCI). We performed this study to evaluate the efficacy TMZ in DM patients with AMI undergoing PCI, such as the effect on reductions in myocardial enzyme, improvements in liver function, modulation of glucose levels, and improvement in cardiac function...
May 23, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28559234/etiology-and-clinical-presentation-of-birth-defects-population-based-study
#14
Marcia L Feldkamp, John C Carey, Janice L B Byrne, Sergey Krikov, Lorenzo D Botto
Objective To assess causation and clinical presentation of major birth defects.Design Population based case cohort.Setting Cases of birth defects in children born 2005-09 to resident women, ascertained through Utah's population based surveillance system. All records underwent clinical re-review.Participants 5504 cases among 270 878 births (prevalence 2.03%), excluding mild isolated conditions (such as muscular ventricular septal defects, distal hypospadias).Main outcome measures The primary outcomes were the proportion of birth defects with a known etiology (chromosomal, genetic, human teratogen, twinning) or unknown etiology, by morphology (isolated, multiple, minors only), and by pathogenesis (sequence, developmental field defect, or known pattern of birth defects)...
May 30, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28550019/measuring-ability-to-assess-claims-about-treatment-effects-a-latent-trait-analysis-of-items-from-the-claim-evaluation-tools-database-using-rasch-modelling
#15
Astrid Austvoll-Dahlgren, Øystein Guttersrud, Allen Nsangi, Daniel Semakula, Andrew D Oxman
BACKGROUND: The Claim Evaluation Tools database contains multiple-choice items for measuring people's ability to apply the key concepts they need to know to be able to assess treatment claims. We assessed items from the database using Rasch analysis to develop an outcome measure to be used in two randomised trials in Uganda. Rasch analysis is a form of psychometric testing relying on Item Response Theory. It is a dynamic way of developing outcome measures that are valid and reliable. OBJECTIVES: To assess the validity, reliability and responsiveness of 88 items addressing 22 key concepts using Rasch analysis...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28532075/can-pei-microgels-become-biocompatible-upon-betainization
#16
Nurettin Sahiner, Sahin Demirci
Polyethylene imine (PEI) microgels prepared via micro emulsion polymerization technique were treated with 1,3-propane sultone to obtained betainized PEI (b-PEI) microgels. The betainization reaction generated zwitterions on PEI microgel that are positive charges from quarternized amine groups of PEI, and the newly formed negative charges from SO3(-) groups from the modifying agent, 1,3-propane sultone offered interesting properties. The smaller size of b-PEI microgels that are obtained by simple filtration were increased with betainization from 512±14 to 1114±86nm...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28527104/low-income-as-a-multiplicative-risk-factor-for-oral-pain-and-dental-problems-among-u-s-veteran-smokers
#17
Terrell A Hicks, Sarah M Wilson, Shaun P Thomas, Paul A Dennis, Julia M Neal, Patrick S Calhoun
PURPOSE: Compared to the United States (U.S.) general population, military veterans are at an increased risk of experiencing dental problems. This study documented associations between cigarette use and measures of dental/oral concern in a population of U.S. veterans who served in Iraq and Afghanistan. METHOD: A cross-sectional analysis of survey data from the Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans Health and Needs Study, a study of U...
May 19, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28526495/automated-external-defibrillator-and-operator-performance-in-out-of-hospital-cardiac-arrest
#18
Jolande A Zijlstra, Loes E Bekkers, Michiel Hulleman, Stefanie G Beesems, Rudolph W Koster
AIM: An increasing number of failing automated external defibrillators (AEDs) is reported: AEDs not giving a shock or other malfunction. We assessed to what extent AEDs are 'failing' and whether this had a device-related or operator-related cause. METHODS: We studied analysis periods from AEDs used between January 2012 and December 2014. For each analysis period we assessed the correctness of the (no)-shock advice (sensitivity/specificity) and reasons for an incorrect (no)-shock advice...
September 2017: Resuscitation
https://www.readbyqxmd.com/read/28455131/echocardiographic-pulmonary-artery-pressure-estimation-and-heart-failure-rehospitalization-burden-in-patients-with-acute-heart-failure
#19
Enrique Santas, Rafael de la Espriella-Juan, Anna Mollar, Ernesto Valero, Gema Miñana, Juan Sanchis, Francisco Javier Chorro, Julio Núñez
Pulmonary hypertension (PH) is a strong predictor of mortality in patients with heart failure (HF). However, the relationship between PH, through echocardiographic pulmonary artery pressure (PASP) estimation, and the risk of HF rehospitalizations remains unclear. METHODS: We prospectively included 2343 consecutive patients discharged for acute heart failure (AHF). PH was estimated by echocardiography through PASP determination during the index admission. Patients were categorized as follows across PASP: non-measurable, normal (≤35mmHg), mild (36-45mmHg), moderate (46-60mmHg), or severe PH (>60mmHg)...
August 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28446915/pruning-system-and-foliar-application-of-mgso-4-alter-yield-and-secondary-metabolite-profile-of-rosa-damascena-under-rainfed-acidic-conditions
#20
Probir K Pal, Mitali Mahajan
Damask rose (Rosa damascena Mill.) is one of the most high-value essential oil-bearing plants in the world. However, the flower yield and quality of essential oil of R. damascena are largely influenced by the pruning practices and balanced supply of plant nutrition. The objective of this study was to test the hypothesis whether the pruning system and foliar fertilization of MgSO4 would influence the flower yield, growth and secondary metabolites profile of R. damascena. A field experiment of 10 treatment combinations comprising two pruning systems (complete and partial) and five levels of MgSO4 (water spray, MgSO4 @ 5...
2017: Frontiers in Plant Science
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