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https://www.readbyqxmd.com/read/29053997/association-of-polycyclic-aromatic-hydrocarbons-exposure-with-atherosclerotic-cardiovascular-disease-risk-a-role-of-mean-platelet-volume-or-club-cell-secretory-protein
#1
Chen Hu, Jian Hou, Yun Zhou, Huizhen Sun, Wenjun Yin, Youjian Zhang, Xian Wang, Guiyang Wang, Weihong Chen, Jing Yuan
BACKGROUND: Inflammation may play an important role in the association between exposure to polycyclic aromatic hydrocarbons (PAHs) and atherosclerotic cardiovascular disease (ASCVD) risk. However, the underlying mechanisms remain unclear. OBJECTIVES: To investigate the association of PAHs exposure with ASCVD risk and effects of mean platelet volume (MPV) or Club cell secretory protein (CC16) on the association. METHODS: A total of 2022 subjects (689 men and 1333 women) were drawn from the baseline Wuhan residents of the Wuhan-Zhuhai Cohort study...
October 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29053901/familial-hypercholesterolaemia-in-patients-with-ischemic-stroke-or-transient-ischemic-attack
#2
Thomas Toell, Lukas Mayer, Raimund Pechlaner, Stefan Krebs, Karin Willeit, Clemens Lang, Christian Boehme, Barbara Prantl, Michael Knoflach, Julia Ferrari, Philipp Fuchs, Wolfgang Prokop, Andrea Griesmacher, Wilfried Lang, Stefan Kiechl, Johann Willeit
BACKGROUND AND AIMS: Identification of patients with familial hypercholesterolemia (FH) is a prerequisite for the appropriate management of their excess cardiovascular risk. It is currently unknown how many patients with acute ischemic stroke or transient ischemic attack (TIA) are affected by FH and whether systematic screening for FH is warranted in these patients. METHODS: The prevalence of a clinical diagnosis of FH was estimated in a large representative series of patients with acute ischemic stroke or TIA (ABCD2 score ≥3) using the Dutch Lipid Clinic Network Algorithm (DLCNA; possible FH ≥3, probable/definite FH ≥6)...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053810/associations-between-cellular-aging-markers-and-metabolic-syndrome-findings-from-the-cardia-study
#3
Dóra Révész, Josine E Verhoeven, Martin Picard, Jue Lin, Stephen Sidney, Elissa S Epel, Brenda W J H Penninx, Eli Puterman
Background: Metabolic syndrome (MetS) is thought to promote biological aging, which might lead to cardiovascular and aging-related complications. This large-scale study investigated longitudinal relationships between MetS, its components, and cellular aging markers: leukocyte mitochondrial DNA copy number (mtDNAcn) and telomere length (TL). Methods: We included 989 participants from the Coronary Artery Risk Development in Young Adults Study. MtDNAcn (CARDIA Years 15, 25) and TL (Y15, Y20, Y25) were measured using quantitative PCR...
October 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29052106/effect-of-low-density-lipoprotein-cholesterol-on-the-geometry-of-coronary-bifurcation-lesions-and-clinical-outcomes-of-coronary-interventions-in-the-j-reverse-registry
#4
Yoshinobu Murasato, Yoshihisa Kinoshita, Masahiro Yamawaki, Toshiro Shinke, Yoshihiro Takeda, Kenichi Fujii, Shin-Ichiro Yamada, Yoshihisa Shimada, Takehiro Yamashita, Kazuhiko Yumoto
We investigated the effect of low-density lipoprotein cholesterol (LDL-C) on the geometry of coronary bifurcation lesions. A total of 300 non-left main bifurcation lesions in 298 patients from J-REVERSE registry were classified according to statin treatment status at admission (NT, non-treated; ST, statin-treated) and were further subdivided based on LDL-C levels with a cutoff of 100 mg/dL (NT-high, n = 76 lesions; NT-low, n = 46; ST-high, n = 99 and ST-low, n = 79). In addition, a group with strict control of LDL-C (< 70 mg/dL) was defined (ST-SC; n = 19)...
October 19, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29052105/impact-of-previous-drug-eluting-stent-restenosis-in-non-left-main-coronary-artery-lesions-on-long-term-outcomes-after-left-main-coronary-artery-stenting-an-observation-from-the-aoi-lmca-registry
#5
Hirooki Higami, Mamoru Toyofuku, Takeshi Morimoto, Masanobu Ohya, Yasushi Fuku, Kyohei Yamaji, Hiromi Muranishi, Yuhei Yamaji, Koji Nishida, Daisuke Furukawa, Tomohisa Tada, Euihong Ko, Kenji Ando, Hiroki Sakamoto, Takashi Tamura, Kazuya Kawai, Kazushige Kadota, Takeshi Kimura
We hypothesized that patients who had previous target-lesion revascularization (TLR) for DES restenosis in non-left main coronary artery (LMCA) lesions might have a higher risk for restenosis after subsequent DES implantation for a de novo unprotected LMCA lesion. Among 1809 patients enrolled in the Assessing Optimal Percutaneous Coronary Intervention for LMCA (AOI-LMCA) registry, which is a retrospective 6-centre registry of consecutive patients undergoing LMCA stenting in Japan, 251 patients with previous DES implantation for non-LMCA lesions were subdivided into the 2 groups with (N = 56) or without (N = 195) previous TLR in non-LMCA lesions...
October 19, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29051975/impact-of-lesion-complexity-on-long-term-vascular-response-to-cobalt-chromium-everolimus-eluting-stent-five-year-follow-up-optical-coherence-tomography-study
#6
Shoichi Kuramitsu, Shinjo Sonoda, Tomohiro Shinozaki, Hiroyuki Jinnouch, Yoshitaka Muraoka, Takenori Domei, Makoto Hyodo, Shinichi Shirai, Kenji Ando, Yutaka Otsuji
The impact of lesion complexity on long-term vascular response to cobalt-chromium everolimus-eluting stent (CoCrEES) remains unclear. We sought to evaluate them using optical coherence tomography (OCT). A total of 47 patients with 58 lesions treated only with CoCrEES and no target-vessel events within 5 years after implantation were prospectively enrolled and underwent 5-year follow-up OCT. Quantitative parameters and qualitative characteristics of the neointima were evaluated using multilevel logistic or linear regression models with random effects at three levels: lesion, cross-section (CS), and strut...
October 19, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29051974/cardiac-disease-in-familial-mediterranean-fever
#7
REVIEW
Eren Erken, Ertugrul Erken
Familial Mediterranean fever (FMF) is an autoinflammatory disease manifested by inflammatory attacks of peritonitis, pleuritis, pericarditis accompanied by fever and arthritis. Mutations of MEFV gene results in pyrin dysfunction, which causes uncontrolled interleukin-1 beta production and triggers the inflammatory attacks. Inflammation persists even during attack-free periods in one-third of the FMF patients. Findings of elevated proinflammatory cytokine patterns during remission as well as inflammatory attacks indicate the continuous subclinical disease activity and inflammation...
October 20, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29051141/coronary-artery-ectasia-predicts-future-cardiac-events-in-patients-with-acute-myocardial-infarction
#8
Takahito Doi, Yu Kataoka, Teruo Noguchi, Tatsuhiro Shibata, Takahiro Nakashima, Shoji Kawakami, Kazuhiro Nakao, Masashi Fujino, Toshiyuki Nagai, Tomoaki Kanaya, Yoshio Tahara, Yasuhide Asaumi, Etsuko Tsuda, Michikazu Nakai, Kunihiro Nishimura, Toshihisa Anzai, Kengo Kusano, Hiroaki Shimokawa, Yoichi Goto, Satoshi Yasuda
OBJECTIVE: Coronary artery ectasia (CAE) is an infrequently observed vascular phenotype characterized by abnormal vessel dilatation and disturbed coronary flow, which potentially promote thrombogenicity and inflammatory reactions. However, whether or not CAE influences cardiovascular outcomes remains unknown. APPROACH AND RESULTS: We investigated major adverse cardiac events (MACE; defined as cardiac death and nonfatal myocardial infarction [MI]) in 1698 patients with acute MI...
October 19, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29051139/mining-the-stiffness-sensitive-transcriptome-in-human-vascular-smooth-muscle-cells-identifies-long-noncoding-rna-stiffness-regulators
#9
Christopher Yu, Tina Xu, Richard Assoian, Daniel J Rader
OBJECTIVE: Vascular extracellular matrix stiffening is a risk factor for aortic and coronary artery disease. How matrix stiffening regulates the transcriptome profile of human aortic and coronary vascular smooth muscle cells (VSMCs) is not well understood. Furthermore, the role of long noncoding RNAs (lncRNAs) in the cellular response to stiffening has never been explored. This study characterizes the stiffness-sensitive (SS) transcriptome of human aortic and coronary VSMCs and identifies potential key lncRNA regulators of stiffness-dependent VSMC functions...
October 19, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29051079/reduced-myocardial-flow-reserve-is-associated-with-diastolic-dysfunction-and-decreased-left-atrial-strain-in-patients-with-normal-ejection-fraction-and-epicardial-perfusion
#10
Matthew C Konerman, Joshua C Greenberg, Theodore J Kolias, James R Corbett, Ravi V Shah, Venkatesh L Murthy, Scott L Hummel
INTRODUCTION: Coronary microvascular dysfunction (MVD) may contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF). Speckle-tracking echocardiography is a feasible and reproducible method for identifying abnormalities in left ventricular (LV) and left atrial (LA) function among HFpEF patients. By assessing myocardial flow reserve (MFR), positron emission tomography (PET) imaging enables quantitative assessment of coronary MVD. We hypothesized that, in patients with risk factors for HFpEF and normal epicardial perfusion on cardiac PET, abnormal MFR is associated with LV diastolic dysfunction (DD) and reduced LV and LA strain...
October 16, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29050980/association-of-low-density-lipoprotein-pattern-with-mortality-after-myocardial-infarction-insights-from-the-triumph-study
#11
Yashashwi Pokharel, Yuanyuan Tang, Bhaskar Bhardwaj, Krishna K Patel, Mohammed Qintar, James H O'Keefe, Krishnaji R Kulkarni, Peter H Jones, Seth S Martin, Salim S Virani, John A Spertus
BACKGROUND: Studies of incident coronary heart disease risk within low-density lipoprotein (LDL) subclass (small, dense vs large, buoyant) have shown mixed results. No prospective cohort study has examined the association of small, dense, or large, buoyant LDL with mortality after myocardial infarction (MI). OBJECTIVE: The objective of the study was to examine association of LDL pattern after MI and death. METHODS: In 2476 patients hospitalized for MI, LDL pattern (A [large, buoyant], A/B [mixed], and B [small, dense]) was established by ultracentrifugation using Vertical Auto Profile...
October 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29050847/anomalous-origin-of-the-left-coronary-artery-from-the-pulmonary-artery-presenting-in-adulthood-a-french-nationwide-retrospective-study
#12
Laura Le Berre, Alban-Elouen Baruteau, Alain Fraisse, Dominique Boulmier, Maria Jimenez, Bruno Gallet, Karine Warin Fresse, Jacques Mansourati, Patrice Guerin
Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital heart disease usually diagnosed during the first months of life. Without surgical treatment, ALCAPA carries a high mortality risk, and disease presentation in adulthood is rare. We describe the diagnosis and management of patients presenting with ALCAPA in adulthood. This multicenter French nationwide retrospective study included adult patients diagnosed from 1980 to 2014. Eleven adult patients (mean age: 38 ± 17 years) were analyzed...
August 25, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29050805/modelling-of-thrombin-generation-under-flow-in-realistic-left-anterior-descending-geometries
#13
Konstantinos P Papadopoulos, Grigoris T Gerotziafas, Manolis Gavaises
Currently there are no available methods for prediction of thrombotic complications in Coronary Artery disease. Additionally, blood coagulation tests are mainly performed in a steady system while coagulation in vivo occurs under flow conditions. In this work, a phenomenological model for coagulation up-to thrombin generation is proposed; the model is mainly based on the results of thrombin generation assays and therefore it can account for the variation of the coagulability that is observed in different individuals...
October 16, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29050797/25-year-physical-activity-trajectories-and-development-of-subclinical-coronary-artery-disease-as-measured-by-coronary-artery-calcium-the-coronary-artery-risk-development-in-young-adults-cardia-study
#14
Deepika R Laddu, Jamal S Rana, Rosenda Murillo, Michael E Sorel, Charles P Quesenberry, Norrina B Allen, Kelley P Gabriel, Mercedes R Carnethon, Kiang Liu, Jared P Reis, Donald Lloyd-Jones, J Jeffrey Carr, Stephen Sidney
OBJECTIVE: To evaluate 25-year physical activity (PA) trajectories from young to middle age and assess associations with the prevalence of coronary artery calcification (CAC). PATIENTS AND METHODS: This study includes 3175 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study who self-reported PA by questionnaire at 8 follow-up examinations over 25 years (from March 1985-June 1986 through June 2010-May 2011). The presence of CAC (CAC>0) at year 25 was measured using computed tomography...
October 13, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29050742/-sudden-cardiac-death-and-anomalous-connections-of-the-coronary-arteries-what-is-known-and-what-is-unknown
#15
P Aubry, X Halna du Fretay, P Degrell, V Waldmann, N Karam, E Marijon
Some anomalous connections of the coronary arteries may be associated with a risk of sudden cardiac death. In opposite with others cardiac diseases at risk of sudden cardiac death, the relationship between these congenital abnormalities and the risk of sudden cardiac death are not well understood. A correction of the anomaly is generally indicated after an aborted sudden cardiac death. Primary prevention strategy after the discovery of an anomaly at risk is debated. Even if the absolute risk of sudden death is very low, a pre-participation screening in young athletes may be discussed due to a non-rare incidence...
October 16, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29050566/how-low-to-go-with-glucose-cholesterol-%C3%A2-and-blood-pressure-in-primary%C3%A2-prevention-of-cvd
#16
REVIEW
Kimberly N Hong, Valentin Fuster, Robert S Rosenson, Clive Rosendorff, Deepak L Bhatt
Diabetes, hyperlipidemia, and hypertension are modifiable risk factors that predict cardiovascular disease events. The effect of these risk factors on incident cardiovascular disease increases with progressively higher levels of glucose, low-density lipoprotein cholesterol, and blood pressure. The thresholds for initiating treatment of these modifiable risk factors and the optimal goals of risk factor modification are a focus of primary prevention research. Although an aggressive approach is appealing, adverse events may occur, and potential physiological barriers may exist...
October 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29050558/similarity-and-difference-of-resting-distal%C3%A2-to-aortic-coronary-pressure-and%C3%A2-instantaneous-wave-free-ratio
#17
Joo Myung Lee, Jonghanne Park, Doyeon Hwang, Chee Hae Kim, Ki Hong Choi, Tae-Min Rhee, Yaliang Tong, Jin Joo Park, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Bon-Kwon Koo
BACKGROUND: Instantaneous wave-free ratio (iFR) has been used in clinical practice to identify functionally significant stenosis and to guide treatment strategy. However, there are limited clinical data regarding another resting pressure-derived index, resting distal to aortic coronary pressure (Pd/Pa), and similarities and differences between resting Pd/Pa and iFR. OBJECTIVES: The authors investigated the changes in resting Pd/Pa and iFR according to anatomic and hemodynamic stenosis severity and their prognostic implications...
October 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29050351/the-prognostic-significance-of-preoperative-left-ventricular-diastolic-dysfunction-and-left-atrial-enlargement-on-acute-coronary-syndrome-in-kidney-transplantation
#18
Jin Ho Hwang, Jun-Bean Park, Yong-Jin Kim, Jung Nam An, Jaeseok Yang, Curie Ahn, In Mok Jung, Chun Soo Lim, Yon Su Kim, Young Hoon Kim, Jung Pyo Lee
Echocardiography is commonly performed as a screening test to evaluate perioperative risks before kidney transplantation. However, only limited data are available on echocardiographic parameters of left ventricular diastolic dysfunction (LVDD) and left atrial enlargement (LAE) on acute coronary syndrome and mortality in kidney transplant recipients. We reviewed 2779 adult recipients who underwent pretransplant echocardiography from 1997 to 2012. We divided the patients into two and four groups by two categories: LVDD grades 0-1 vs...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050285/high-dose-atorvastatin-reduces-the-risk-of-cardiovascular-events-in-patients-with-percutaneous-coronary-intervention
#19
Changqing Lu, Helei Jia, Zhentao Wang
We systematically searched in PubMed, Web of Science, Embase and China National Knowledge Infrastructure from the inception to March 31, 2017, identified relevant trials about efficacy of high-does Atorvastatin for patients with percutaneous coronary intervention. Twelve studies with the number of 2801 patients were included in the meta-analysis. Compared with control group, high-does Atorvastatin significantly reduced the risk of myocardial infarction in patients with percutaneous coronary intervention (Relative risk =0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049831/improving-myocardial-fractional-flow-reserve-in-coronary-atherosclerosis-via-cx37-gene-silence-a-preclinical-validation-study-in-pigs
#20
Suxia Guo, Ying Yang, Zhenyu Yang, Huayan You, Yunke Shi, Zhao Hu, Zhaohui Meng, Jianming Xiao
OBJECTIVES: The purpose of this study was to evaluate the effect of CX37 gene silence on myocardial fractional flow reserve (FFR). METHODS: A total of 90 male pigs were randomly divided into saline, mock and 3 different doses (5, 10 and 20 µl) of CX37 viral suspension groups that could induce coronary plaque formation with high-fat diet. After performing myocardial FFR by intravascular ultrasound, different doses of CX37 viral suspension, saline and mock small interfering RNA (siRNA) were transfected into the related coronary...
July 31, 2017: Interactive Cardiovascular and Thoracic Surgery
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