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coronary disease biom

Andrew DeRouin, Roger Guillory, Weilue He, Megan Frost, Jeremy Goldman, Keat Ghee Ong
The gold standard of care for coronary artery disease, a leading cause of death for in the world, is balloon angioplasty in conjunction with stent deployment. However, implantation injuries and long-term presence of foreign material often promotes significant luminal tissue growth, leading to a narrowing of the artery and severely restricted blood flow. A promising method to mitigate this process is the use of biodegradable metallic stents, but thus far they have either degraded too slowly (iron) or disappeared prematurely (magnesium)...
March 23, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Rajesh Lakshmanan, Nilanjana Maulik
Cardiovascular diseases (CVDs) rank, next to cancer and stroke, among the deadliest diseases in the world. Among the major CVDs, acute myocardial infarction is a life-threatening disorder resulting from permanent damage to the left ventricular cardiac tissue. The major coronary arteries that supply blood to the functional left ventricle become blocked due to thrombotic plaque occlusion. During myocardial ischemia, oxidative stress and free radicals destroy healthy cardiomyocytes, smooth muscle cells, and endothelial cells, followed by degradation of the extracellular matrix, which results in ventricular wall-thinning and dilation...
September 26, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Rita Pavasini, Matteo Serenelli, Francesco Gallo, Giulia Bugani, Salvatore Geraci, Paolo Vicinelli, Gianluca Campo
BACKGROUND: In the last years bioresorbable vascular scaffold (BVS) become a new therapeutic option for interventional cardiologists, with the advantage of a scaffold inducing a possible vessel wall restoration. Nevertheless, several trials tried to prove the safety and efficacy profile of scaffolds, but with conflicting results. METHODS: A systematic review and meta-analysis was performed. The search was carried out in PubMed, Google Scholar, Biomed Central and Cochrane Library between January and March 2017...
August 2017: Journal of Thoracic Disease
William Herrington, Jonathan Emberson, Borislava Mihaylova, Lisa Blackwell, Christina Reith, Marit Solbu, Patrick Mark, Bengt Fellström, Alan Jardine, Christoph Wanner, Hallvard Holdaas, Jordan Fulcher, Richard Haynes, Martin Landray, Anthony Keech, John Simes, Rory Collins, Colin Baigent
BACKGROUND: Statin therapy is effective for the prevention of coronary heart disease and stroke in patients with mild-to-moderate chronic kidney disease, but its effects in individuals with more advanced disease, particularly those undergoing dialysis, are uncertain. METHODS: We did a meta-analysis of individual participant data from 28 trials (n=183 419), examining effects of statin-based therapy on major vascular events (major coronary event [non-fatal myocardial infarction or coronary death], stroke, or coronary revascularisation) and cause-specific mortality...
October 2016: Lancet Diabetes & Endocrinology
Fu-Bin Yang, Wan-Liang Guo, Mao Sheng, Ling Sun, Yue-Yue Ding, Qiu-Qin Xu, Ming-Guo Xu, Hai-Tao Lv
OBJECTIVES: To conduct a meta-analysis and investigate the diagnostic value of 64-slice computed tomography (CT) angiography for diagnosing coronary artery disease (CAD) in patients. METHODS: A comprehensive literature search from March 2005 to August 2014 was performed on the following databases: Cochrane Library; Medline; EmBase; PubMed; and BioMed Central database. As a reference standard, studies that assessed 64-slice CT angiography in detecting coronary artery stenosis (CAS) with invasive coronary angiography were included...
October 2015: Saudi Medical Journal
Hualin Lan, Yi Wang, Tieyin Yin, Yazhou Wang, Wanqian Liu, Xiaojuan Zhang, Qinsong Yu, Zhaoxu Wang, Guixue Wang
Drug-eluting stents (DES) have been widely used to treat coronary artery disease (CAD) since their clinical use has significantly reduced the occurrence of in-stent restenosis (ISR) as compared with the initially applied bare-metal stents (BMS). However, analyses of long-term clinical outcome have raised concerns about the serious safety problem of DES, such as ISR caused by late or very late thrombosis. Various studies showed that those complications were associated with vascular endothelial injury/dysfunction or endothelialization delaying...
August 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
S Braune, M Groß, M Walter, S Zhou, S Dietze, S Rutschow, A Lendlein, C Tschöpe, F Jung
On the basis of the clinical studies in patients with coronary artery disease (CAD) presenting an increased percentage of activated platelets, we hypothesized that hemocompatibility testing utilizing platelets from healthy individuals may result in an underestimation of the materials' thrombogenicity. Therefore, we investigated the interaction of polymer-based biomaterials with platelets from CAD patients in comparison to platelets from apparently healthy individuals. In vitro static thrombogenicity tests revealed that adherent platelet densities and total platelet covered areas were significantly increased for the low (polydimethylsiloxane, PDMS) and medium (Collagen) thrombogenic surfaces in the CAD group compared to the healthy subjects group...
January 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Jordan Fulcher, Rachel O'Connell, Merryn Voysey, Jonathan Emberson, Lisa Blackwell, Borislava Mihaylova, John Simes, Rory Collins, Adrienne Kirby, Helen Colhoun, Eugene Braunwald, John La Rosa, T R Pedersen, Andrew Tonkin, Barry Davis, Peter Sleight, Maria Grazia Franzosi, Colin Baigent, Anthony Keech
BACKGROUND: Whether statin therapy is as effective in women as in men is debated, especially for primary prevention. We undertook a meta-analysis of statin trials in the Cholesterol Treatment Trialists' (CTT) Collaboration database to compare the effects of statin therapy between women and men. METHODS: We performed meta-analyses on data from 22 trials of statin therapy versus control (n=134,537) and five trials of more-intensive versus less-intensive statin therapy (n=39,612)...
April 11, 2015: Lancet
Yang Liu, Jiang Zhang, Jian Wang, Yuan Wang, Zheng Zeng, Tao Liu, Junying Chen, Nan Huang
Coronary artery disease is a great threat to human health and is the leading killer worldwide. Percutaneous coronary intervention is the most effective therapy; however, thrombus, and restenosis caused by endothelium injury continue to be problematic after treatment. It is widely accepted that surface biofunctional modification to improve blood compatibility and accelerate endothelialization may be an effective approach to prevent the occurrence of adverse cardiac events. In this study, novel VEGF-loaded heparin/poly-L-lysine (Hep/PLL) particles were developed and immobilized on a dopamine coated titanium surface...
June 2015: Journal of Biomedical Materials Research. Part A
Enrico Cerrato, Fabrizio D'Ascenzo, Giuseppe Biondi-Zoccai, Andrea Calcagno, Simone Frea, Walter Grosso Marra, Davide Castagno, Pierluigi Omedè, Giorgio Quadri, Filippo Sciuto, Davide Presutti, Giacomo Frati, Stefano Bonora, Claudio Moretti, Fiorenzo Gaita
AIMS: Human immunodeficiency virus infection (HIV) has been associated with cardiac dysfunction that, if present, can negatively affect morbidity and mortality of HIV-infected patients. Unfortunately, many of the studies on this topic were performed before the highly active antiretroviral therapy (HAART) was established. Thus, we performed a comprehensive meta-analysis to critically appraise the incidence of cardiac dysfunction in HIV-infected pauci symptomatic patients. METHODS AND RESULTS: Medline, Cochrane Library, and Biomed Central were systematically screened for studies reporting on systolic and/or diastolic dysfunctions in HIV pauci-symptomatic patients...
May 2013: European Heart Journal
Fabrizio D'Ascenzo, Pierfrancesco Agostoni, Antonio Abbate, Davide Castagno, Michael J Lipinski, George W Vetrovec, Giacomo Frati, Davide Giacomo Presutti, Giorgio Quadri, Claudio Moretti, Fiorenzo Gaita, Giuseppe Biondi Zoccai
INTRODUCTION: Atherosclerotic coronary plaques represent the main substrate for coronary artery disease (CAD), and changes in plaque volume, investigated with intravascular ultrasound (IVUS), have been used as surrogate end-points in several clinical trials. However, no conclusive data are available to support the exploitation of IVUS-based plaque changes as a measure of clinically meaningful treatment's effect. METHODS: Biomed Central, CENTRAL, and Medline/PubMed were searched for randomized clinical trials investigating IVUS variations of plaque and reporting clinical events...
January 2013: Atherosclerosis
B Mihaylova, J Emberson, L Blackwell, A Keech, J Simes, E H Barnes, M Voysey, A Gray, R Collins, C Baigent
BACKGROUND: Statins reduce LDL cholesterol and prevent vascular events, but their net effects in people at low risk of vascular events remain uncertain. METHODS: This meta-analysis included individual participant data from 22 trials of statin versus control (n=134,537; mean LDL cholesterol difference 1·08 mmol/L; median follow-up 4·8 years) and five trials of more versus less statin (n=39,612; difference 0·51 mmol/L; 5·1 years). Major vascular events were major coronary events (ie, non-fatal myocardial infarction or coronary death), strokes, or coronary revascularisations...
August 11, 2012: Lancet
C Baigent, L Blackwell, J Emberson, L E Holland, C Reith, N Bhala, R Peto, E H Barnes, A Keech, J Simes, R Collins
BACKGROUND: Lowering of LDL cholesterol with standard statin regimens reduces the risk of occlusive vascular events in a wide range of individuals. We aimed to assess the safety and efficacy of more intensive lowering of LDL cholesterol with statin therapy. METHODS: We undertook meta-analyses of individual participant data from randomised trials involving at least 1000 participants and at least 2 years' treatment duration of more versus less intensive statin regimens (five trials; 39 612 individuals; median follow-up 5·1 years) and of statin versus control (21 trials; 129 526 individuals; median follow-up 4·8 years)...
November 13, 2010: Lancet
Colin Baigent, Lisa Blackwell, Rory Collins, Jonathan Emberson, Jon Godwin, Richard Peto, Julie Buring, Charles Hennekens, Patricia Kearney, Tom Meade, Carlo Patrono, Maria Carla Roncaglioni, Alberto Zanchetti
BACKGROUND: Low-dose aspirin is of definite and substantial net benefit for many people who already have occlusive vascular disease. We have assessed the benefits and risks in primary prevention. METHODS: We undertook meta-analyses of serious vascular events (myocardial infarction, stroke, or vascular death) and major bleeds in six primary prevention trials (95,000 individuals at low average risk, 660,000 person-years, 3554 serious vascular events) and 16 secondary prevention trials (17,000 individuals at high average risk, 43,000 person-years, 3306 serious vascular events) that compared long-term aspirin versus control...
May 30, 2009: Lancet
Michèle Hamon, Olivier Lepage, Patrizia Malagutti, John W Riddell, Rémy Morello, Denis Agostini, Martial Hamon
PURPOSE: To perform a meta-analysis to evaluate the accuracy of 16- and 64-section spiral computed tomography (CT) to help assess coronary artery bypass grafts (CABGs). MATERIALS AND METHODS: The MEDLINE, Cochrane library, and BioMed Central databases were searched for relevant original articles published up to May 2007. Major criteria for article inclusion were that it (a) used multisection CT as a diagnostic test for the assessment of significant lesions (occlusion or >50% stenosis) of CABG, (b) used a 16- or 64-section scanner, and (c) used coronary angiography as the reference standard...
June 2008: Radiology
Hua Wang, Hui-Min Wang, Qing-Hui Jin, Hui Cong, Gui-Sheng Zhuang, Jian-Long Zhao, Cheng-Long Sun, Hong-Wei Song, Wei Wang
Small, dense low-density lipoprotein (sdLDL) has been accepted as an emerging cardiovascular risk factor, and there has been an increasing interest in analytical methods for sdLDL profiling for diagnosis. Serum sdLDL may be measured by different laboratory techniques, but all these methods are laborious, time-consuming, and costly. Recently, we have demonstrated that a low-temperature bonding of quartz microfluidic chips for serum lipoproteins analysis (Zhuang, G., Jin, Q., Liu, J., Cong, H. et al., Biomed...
May 2008: Electrophoresis
P de Smet, S Sans, M Dramaix, C Boulenguez, G de Backer, M Ferrario, G Cesana, I Houtman, S O Isacsson, F Kittel, P O Ostergren, I Peres, E Pelfrene, M Romon, A Rosengren, L Wilhelmsen, M Kornitzer
BACKGROUND: Over the last 20 years stress at work has been found to be predictive of several conditions such as coronary heart disease, high blood pressure and non-specific sick leave. The Karasek demand/control/strain concept has been the most widely used in prospective epidemiological studies. OBJECTIVES: To describe distribution in Karasek's demand/control (DC) dimensions as well as prevalence of strain in samples from different parts of Europe grouped into three regions (South, Middle, Sweden), adjusting for occupation...
October 2005: European Journal of Public Health
G G L Biondi-Zoccai, P Agostoni, L Testa, A Abbate, Q Parisi, F Burzotta, C Trani, R Mongiardo, C Vassanelli, L M Biasucci
AIM: Clopidogrel is an established alternative to ticlopidine in addition to aspirin after coronary stenting because of its hematologic safety, but its efficacy in comparison to ticlopidine is debated. We thus systematically reviewed randomized trials comparing clopidogrel vs ticlopidine after coronary stenting. METHODS: Medline (1/1986-10/2003), BioMed Central, Central, Current Contents, LILACS and mRCT were searched. Fixed-effect relative risks (RR [95% CI]) were computed, and the primary end-point was death...
June 2004: Minerva Cardioangiologica
E Ackerman
The first tutorial in this series (Ackerman E: Simulation of micropopulations in epidemiology: Tutorial 1. Simulation: an introduction, Int J Biomed Comput, 36 (1994) 229-238) introduces the general approach of simulation of micropopulation models of coronary disease using Monte Carlo techniques. The modeling process includes the selection of functional forms to represent the probability of state transfers. Alternative functional forms are described in the second tutorial (Ackerman E: Simulation of micropopulations in epidemiology: Tutorial 2...
May 1995: International Journal of Bio-medical Computing
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