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https://www.readbyqxmd.com/read/28647468/influence-of-rabbit-notochordal-cells-on-symptomatic-intervertebral-disc-degeneration-anti-angiogenic-capacity-on-human-endothelial-cell-proliferation-under-hypoxia
#1
Woo-Keun Kwon, Hong Joo Moon, Taek-Hyun Kwon, Youn-Kwan Park, Joo Han Kim
OBJECTIVES: Symptomatic degenerative disc disease (DDD) is associated with neovascularization and nerve ingrowth into intervertebral discs (IVDs). Notochordal cells (NCs) are key cells that may lead to regeneration of IVDs. However, their activities under conditions of hypoxia, the real environment of IVD, are not well known. We hypothesized that NCs may inhibit neovascularization by interacting with endothelial cells (ECs) under hypoxia. DESIGN: Human IVDs were isolated and cultured to produce nucleus pulposus (NP) cell conditioned medium (NPCM)...
June 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28646455/human-nucleus-pulposus-intervertebral-disc-cells-becoming-senescent-using-different-treatments-exhibit-a-similar-transcriptional-profile-of-catabolic-and-inflammatory-genes
#2
Sotiris-Spyros Vamvakas, Eleni Mavrogonatou, Dimitris Kletsas
PURPOSE: Chronic low back pain has been associated with intervertebral disc (IVD) degeneration, which is characterized by the accumulation of extracellular matrix (ECM)-degrading proteases and inflammatory molecules in the degenerate tissue. IVD degeneration could be the outcome of natural organismal ageing and/or of the exposure of the disc to cumulative stressful environmental stimuli and is accompanied by an increased population of senescent cells in the tissue. On the other hand, senescent cells are known to secrete proteolytic enzymes and inflammatory molecules, which can contribute to ECM catabolism...
June 23, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28646230/il-1%C3%AE-increases-asporin-expression-via-the-nf-%C3%AE%C2%BAb-p65-pathway-in-nucleus-pulposus-cells-during-intervertebral-disc-degeneration
#3
Shengjie Wang, Chao Liu, Zhongyi Sun, Peng Yan, He Liang, Kai Huang, Changwei Li, Jiwei Tian
Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular matrix (ECM) proteins in the disc are the leading factors contributing to DD. Asporin is an ECM protein that has been shown to be increased in degenerated intervertebral discs, but little is known about how asporin is regulated during DD. In exploring the intricate mechanism, we confirmed that asporin was abundantly increased in patients' degenerated nucleus pulposus...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645289/degenerative-changes-of-the-canine-cervical-spine-after-discectomy-procedures-an-in-vivo-study
#4
Peter Grunert, Yu Moriguchi, Brian P Grossbard, Rodolfo J Ricart Arbona, Lawrence J Bonassar, Roger Härtl
BACKGROUND: Discectomies are a common surgical treatment for disc herniations in the canine spine. However, the effect of these procedures on intervertebral disc tissue is not fully understood. The objective of this study was to assess degenerative changes of cervical spinal segments undergoing discectomy procedures, in vivo. RESULTS: Discectomies led to a 60% drop in disc height and 24% drop in foraminal height. Segments did not fuse but showed osteophyte formation as well as endplate sclerosis...
June 23, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28645219/pullulan-microbeads-si-hpmc-hydrogel-injectable-system-for-the-sustained-delivery-of-gdf-5-and-tgf-%C3%AE-1-new-insight-into-intervertebral-disc-regenerative-medicine
#5
Nina Henry, Johann Clouet, Audrey Fragale, Louise Griveau, Claire Chédeville, Joëlle Véziers, Pierre Weiss, Jean Le Bideau, Jérôme Guicheux, Catherine Le Visage
Discogenic low back pain is considered a major health concern and no etiological treatments are today available to tackle this disease. To clinically address this issue at early stages, there is a rising interest in the stimulation of local cells by in situ injection of growth factors targeting intervertebral disc (IVD) degenerative process. Despite encouraging safety and tolerability results in clinic, growth factors efficacy may be further improved. To this end, the use of a delivery system allowing a sustained release, while protecting growth factors from degradation appears of particular interest...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28642835/differential-carbonyl-stress-expression-in-the-intervertebral-disc-between-singular-and-persistent-mechanical-injuries
#6
Itaru Hibino, Simon Tang
Low back pain is a significant public health problem worldwide. Intervertebral disc degeneration is most significant known risk factor for low back pain. Yet the mechanisms of degeneration remain relatively unknown. Carbonyl stress and oxidation have been implicated in cartilage and fibrocartilage degeneration. Here we investigate the role of oxidative stress and carbonyl production in the intervertebral disc after mechanical injury using an in vitro organ model of the mouse functional spine unit. We use a single-stab insult to model mild injury, and the three-stab insult to model severe trauma...
2017: Nagoya Gakuin Daigaku Ronshu Igaku Kenko Kagaku Supotsu Kagakuhen
https://www.readbyqxmd.com/read/28640098/the-characteristics-of-stem-cells-in-human-degenerative-intervertebral-disc
#7
Lin Liang, Xuefeng Li, Dapeng Li, Weimin Jiang, Heng Wang, Jie Chen, Zhiyong Sun, Niannian Zhang, Yangyi Zhu
BACKGROUND: The aim of this study is to identify which possessed the best stem-cell-like characteristics in 3 kinds of cell in human degenerative intervertebral disc: NPSCs (nucleus pulposus-derived stem cells), AFSCs (annulus fibrosus-derived stem cells), or CESCs (cartilage endplate-derived stem cells). METHODS: We separated the disc samples obtained from 15 surgically treated patients with disc degenerative diseases into nucleus pulposus, annulus fibrosus, and cartilage endplate...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28638296/ultrasound-guided-percutaneous-cervical-and-upper-thoracic-sympathetic-chain-neuromodulation-for-upper-extremity-complex-regional-pain-syndrome
#8
Samer Narouze, Dmitri Souzdalnitski
BACKGROUND: Complex regional pain syndrome (CRPS) comprises a group of conditions characterized by severe, debilitating pain that is disproportionate to any inciting event and is not distributed in a specific nerve distribution or dermatome. CASE REPORT: A 42-year-old female with a 2-year history of right upper extremity CRPS type I refractory to conventional management underwent an ultrasound-guided and fluoroscopy confirmed percutaneous peripheral nerve stimulation trial with a lead extending from the C6 to the T3 level to cover the cervical and upper thoracic sympathetic chain...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28634047/the-study-of-the-intervertebral-disc-microstructure-in-matured-rats-with-diffusion-kurtosis-imaging
#9
Li Li, Wenzhen Zhu, Weiwei Chen, Jicheng Fang, Jing Li
OBJECTIVES: The aim of this study was to use DKI to detect the microstructural change of the discs in matured normal rats. METHODS: Total 24 normal SD rats (12 males/12 females) underwent DWI/DKI and T2 sequences with a 3T MRI scanner to get the values of ADC, FA, MD, Da, Dr, MK, Ka and Kr. The discs were categorized using a five-grade degeneration grading system in the T2-images. The height of the discs and the parameters in DWI/DKI were measured to compare between the different grades and sexes...
June 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28632557/vertebral-end-plate-perforation-for-intervertebral-disc-height-preservation-after-single-level-lumbar-discectomy-a-randomized-controlled-trial
#10
Miha Vodičar, Robert Košak, Matevž Gorenšek, Robert Korez, Tomaž Vrtovec, Jadran Koder, Vane Antolič, Rok Vengust
STUDY DESIGN: Pilot single-centre, stratified, prospective, randomized, double-blinded, parallel-group, controlled study. OBJECTIVE: To determine whether vertebral end-plate perforation after lumbar discectomy causes annulus reparation and intervertebral disc volume restoration. To determine that after 6 months there would be no clinical differences between the control and study group. SUMMARY OF BACKGROUND DATA: Low back pain is the most common long-term complication after lumbar discectomy...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28631843/age-related-spontaneous-lumbar-intervertebral-disc-degeneration-in-a-mouse-model
#11
Takashi Ohnishi, Hideki Sudo, Takeru Tsujimoto, Norimasa Iwasaki
The pathogenesis of intervertebral disc degeneration is unclear, but it is a major cause of several spinal diseases. Animal models have historically provided an appropriate benchmark for understanding the human spine. However, there is little information about when intervertebral disc degeneration begins in the mouse or regarding the relationship between magnetic resonance imaging and histological findings. The aim for this study was to obtain information about age-related spontaneous intervertebral disc degeneration in the mouse lumbar spine using magnetic resonance imaging and a histological score regarding when the intervertebral disc degeneration started and how rapidly it progressed, as well as how our histological score detected the degeneration...
June 20, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28630396/comparison-of-lavage-techniques-for-preventing-incision-infection-following-posterior-lumbar-interbody-fusion
#12
Jun Fei, Jianhua Gu
BACKGROUND The main purpose of this study was to compare the effects of various lavage techniques - traditional saline lavage (SL), pulse lavage (PL), closed drainage (CD), and iodine lavage (IL) - on preventing incision-related infection after posterior lumbar interbody fusion. MATERIAL AND METHODS Patients with prolapsed lumbar (intervertebral) discs (PLID) undergoing posterior lumbar interbody fusion surgery (PLIF) over the course of 2 years were included and were randomly allocated into 4 groups: the SL group, the PL group, the CD group, and the IL group...
June 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28624722/age-related-differences-in-the-response-of-the-l5-s1-intervertebral-disc-to-spinal-traction
#13
Ulrike H Mitchell, Paul F Beattie, Jennifer Bowden, Robert Larson, Haonan Wang
BACKGROUND: Lumbar traction is a common treatment for low back pain; however its mechanisms of action are poorly understood. It has been hypothesized that a key effect of lumbar traction is its capacity to influence fluid movement within the intervertebral disc (IVD). OBJECTIVES: To determine differences in the apparent diffusion coefficient (ADC) obtained with lumbar diffusion-weighted imaging (DWI) of the L5-S1 IVD before, and during, the application of lumbar traction...
June 9, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28622909/biomechanical-evaluation-of-a-novel-pedicle-screw-based-interspinous-spacer-a-finite-element-analysis
#14
Hsin-Chang Chen, Jia-Lin Wu, Shou-Chieh Huang, Zheng-Cheng Zhong, Shiu-Ling Chiu, Yu-Shu Lai, Cheng-Kung Cheng
Interspinous spacers have been designed to provide a minimally invasive surgical technique for patients with lumbar spinal stenosis or foraminal stenosis. A novel pedicle screw-based interspinous spacer has been developed in this study, and the aim of this finite element experiment was to investigate the biomechanical differences between the pedicle screw-based interspinous spacer (M-rod system) and the typical interspinous spacer (Coflex-F™). A validated finite element model of an intact lumbar spine was used to analyze the insertions of the Coflex-F™, titanium alloy M-rod (M-Ti), and polyetheretherketone M-rod (M-PEEK), independently...
June 13, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28622896/biomechanical-modeling-of-spine-flexibility-and-its-relationship-to-spinal-range-of-motion-and-idiopathic-scoliosis
#15
Tishya A L Wren, Skorn Ponrartana, Ervin Poorghasamians, Sarah Moreau, Patricia C Aggabao, Tracy L Zaslow, Bianca R Edison, Vicente Gilsanz
STUDY DESIGN: Cross-sectional. OBJECTIVE: To examine the relationships between spine morphology, spine flexibility, and idiopathic scoliosis. BACKGROUND: Girls have a higher incidence of clinically significant scoliosis than boys, along with smaller vertebrae and greater flexibility. Based on biomechanical modeling, we hypothesized that smaller vertebral width relative to intervertebral disc (IVD) height would be associated with both greater lateral flexibility of the spine and with idiopathic scoliosis...
July 2017: Spine Deformity
https://www.readbyqxmd.com/read/28621199/sciatic-nerve-regeneration-by-transplantation-of-in-vitro-differentiated-nucleus-pulposus-progenitor-cells
#16
Takayuki Ishii, Daisuke Sakai, Jordy Schol, Tomoko Nakai, Kaori Suyama, Masahiko Watanabe
AIM: To assess the applicability of mouse intervertebral disc-derived nucleus pulposus (NP) progenitor cells as a cell source for sciatic nerve regeneration. MATERIALS & METHODS: P0-Cre/Floxed-EGFP-transgenic mouse-derived NP progenitor cells were differentiated to Schwann-like cells in conventional induction medium. Schwann-like cells were subsequently transplanted into a mouse model of sciatic nerve transection, and nerve regeneration assessed by immunohistochemistry, electron microscopy and functional walking track analysis and heat stimulus reflex...
June 16, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28620118/role-of-p38-mapk-pathway-in-the-effects-of-high-magnitude-compression-on-nucleus-pulposus-cell-senescence-in-a-disc-perfusion%C3%A2-culture
#17
Pei Li, Ruijie Zhang, Yuan Xu, Lei Song, Qiang Zhou
Nucleus pulposus (NP) cell senescence is a typical pathological feature within the degenerative intervertebral disc. As a potential inducing and aggregating factor of disc degeneration, mechanical overloading affects disc biology in multiple ways. This study was to investigate the NP cell senescence-associated phenotype under intermittent high compression in an ex vivo disc bioreactor culture, and the role of the p38-MAPK pathway in this regulatory process. Porcine discs were cultured in culture chambers of a self-developed mechanically active bioreactor and subjected to different magnitudes of dynamic compression (low-magnitude and high-magnitude: 0...
June 15, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28619001/icariin-attenuates-interleukin-1%C3%AE-induced-inflammatory-response-in-human-nucleus-pulposus-cells
#18
Wen-Bin Hua, Yu-Kun Zhang, Xing-Huo Wu, Liang Kang, Ji Tu, Kang-Cheng Zhao, Shuai Li, Kun Wang, Yu Song, Rong-Jin Luo, Zeng-Wu Shao, Cao Yang
BACKGROUND: Low back pain is a common problem, mainly caused by intervertebral disc degeneration (IDD). An important pathophysiological characteristic of IDD is the loss of homeostatic balance of the extracellular matrix metabolism. Interleukin-1β (IL-1β) is one of the inflammatory mediators stimulating the degradation of extracellular matrix in the nucleus pulposus (NP) and contributing to IDD pathogenesis. Icariin, which is isolated from Epimedium brevicornum, acts as an anti-inflammatory drug...
June 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28615510/formation-function-and-exhaustion-of-notochordal-cytoplasmic-vacuoles-within-intervertebral-disc-current-understanding-and-speculation
#19
REVIEW
Feng Wang, Zeng-Xin Gao, Feng Cai, Arjun Sinkemani, Zhi-Yang Xie, Rui Shi, Ji-Nan Wei, Xiao-Tao Wu
Notochord nucleus pulposus cells are characteristic of containing abundant and giant cytoplasmic vacuoles. This review explores the embryonic formation, biological function, and postnatal exhaustion of notochord vacuoles, aiming to characterize the signal network transforming the vacuolated nucleus pulposus cells into the vacuole-less chondrocytic cells. Embryonically, the cytoplasmic vacuoles within vertebrate notochord originate from an evolutionarily conserved vacuolation process during neurulation, which may continue to provide mechanical and signal support in constructing a mammalian intervertebral disc...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28612187/enhancement-of-energy-production-of-the-intervertebral-disc-by-the-implantation-of-polyurethane-mass-transfer-devices
#20
Yu-Fu Wang, Howard B Levene, Weiyong Gu, C -Y Charles Huang
Insufficient nutrient supply has been suggested to be one of the etiologies for intervertebral disc (IVD) degeneration. We are investigating nutrient transport into the IVD as a potential treatment strategy for disc degeneration. Most cellular activities in the IVD (e.g., cell proliferation and extracellular matrix production) are mainly driven by adenosine-5'-triphosphate (ATP) which is the main energy currency. The objective of this study was to investigate the effect of increased mass transfer on ATP production in the IVD by the implantation of polyurethane (PU) mass transfer devices...
June 13, 2017: Annals of Biomedical Engineering
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