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https://www.readbyqxmd.com/read/29222837/low-melt-bioactive-glass-reinforced-3d-printing-akermanite-porous-cages-with-highly-improved-mechanical-properties-for-lumbar-spinal-fusion
#1
Xiurong Ke, Lei Zhang, Xianyan Yang, Juncheng Wang, Chen Zhuang, Zhouwen Jin, An Liu, Tengfei Zhao, Sanzhong Xu, Changyou Gao, Zhongru Gou, Guojing Yang
Although great strides have been made in medical technology, low back/neck pain and intervertebral disc degeneration initiated from disc degenerative disease remains a clinical challenge. Within the field of regenerative medicine therapy, we have sought to improve the biomechanical transformation of spinal fusion procedures conducted using biodegradable porous implants. Specifically, we have focused on developing mechanically strong bioceramic cages for spinal fusion and functional recovery. Herein we fabricated the akermanite (AKE) ceramic-based porous cages using low-melting bioactive glass (BG) and 3D printing technology...
December 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29221904/tensile-behaviour-of-individual-fibre-bundles-in-the-human-lumbar-anulus-fibrosus
#2
Diana T Pham, Joe G Shapter, John J Costi
Disc degeneration is a common medical affliction whose origins are not fully understood. An improved understanding of its underlying mechanisms could lead to the development of more effective treatments. The aim of this paper was to investigate the effect of (1) degeneration, (2) circumferential region and (3) strain rate on the microscale mechanical properties (toe region modulus, linear modulus, extensibility, phase angle) of individual fibre bundles in the anulus fibrosus lamellae of the human intervertebral disc...
November 28, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29220729/comparison-of-dynamic-cervical-implant-versus-anterior-cervical-discectomy-and-fusion-for-the-treatment-of-single-level-cervical-degenerative-disc-disease-a-five-year-follow-up
#3
Ce Zhu, Xi Yang, Lei Wang, Bo-Wen Hu, Li-Min Liu, Lin-Nan Wang, Hao Liu, Yue-Ming Song
OBJECTIVE: To compare clinical and radiographic outcomes of dynamic cervical implant(DCI) with anterior cervical discectomy and fusion(ACDF) in the treatment of single-level cervical degenerative disc disease (CDDD) 5 years after surgery. PATIENTS AND METHODS: Forty-three patients with DCI were matched one-to-one with patients with ACDF based on age, gender, and operative segment in this retrospective study. All patients had been followed up for more than 5 years...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29218230/spondylodiscitis-revisited
#4
Andreas F Mavrogenis, Panayiotis D Megaloikonomos, Vasileios G Igoumenou, Georgios N Panagopoulos, Efthymia Giannitsioti, Antonios Papadopoulos, Panayiotis J Papagelopoulos
Spondylodiscitis may involve the vertebral bodies, intervertebral discs, paravertebral structures and spinal canal, with potentially high morbidity and mortality rates.A rise in the susceptible population and improved diagnosis have increased the reported incidence of the disease in recent years.Blood cultures, appropriate imaging and biopsy are essential for diagnosis and treatment.Most patients are successfully treated by conservative means; however, some patients may require surgical treatment.Surgical indications include doubtful diagnosis, progressive neurological deficits, progressive spinal deformity, failure to respond to treatment, and unresolved pain...
November 2017: EFORT Open Reviews
https://www.readbyqxmd.com/read/29215065/toll-like-receptor-activation-induces-degeneration-of-human-intervertebral-discs
#5
Emerson Krock, Derek H Rosenzweig, J Brooke Currie, Daniel G Bisson, Jean A Ouellet, Lisbet Haglund
Toll-like receptors (TLR) are activated by endogenous alarmins such as fragmented extracellular matrix compounds found in the degenerating disc. TLRs regulate cytokine, neurotrophin, and protease expression in human disc cells in vitro, and thus control key factors in disc degeneration. However, whether TLR activation leads to degenerative changes in intact human discs is unclear. Nucleus pulposus (NP) cells isolated from non-degenerating discs increase IL-1β and nerve growth factor gene expression following treatment with Pam2CSK4 (TLR2/6 agonist) but not Pam3CSK4 (TLR1/2 agonist)...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214889/cell-seeded-adhesive-biomaterial-for-repair-of-annulus-fibrosus-defects-in-intervertebral-discs
#6
Michelle A Cruz, Warren W Hom, Distefano Tyler, Robert Merrill, Olivia M Torre, Huizi A Lin, Andrew Hecht, Svenja Illien-Junger, James C Iatridis
Defects in the annulus fibrosus (AF) of intervertebral discs allow nucleus pulposus tissue to herniate causing painful disability. Microdiscectomy procedures remove herniated tissue fragments but unrepaired defects remain allowing reherniation or progressive degeneration. Cell therapies show promise to enhance repair but methods are undeveloped and carriers are required to prevent cell leakage. To address this challenge, this study developed and evaluated genipin-crosslinked fibrin (FibGen) as an adhesive cell carrier optimized for AF repair that can deliver cells, match AF material properties and have low risk of extrusion during loading...
December 7, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29214370/lumbar-intervertebral-disc-allograft-transplantation-the-revascularisation-pattern
#7
Yong-Can Huang, Jun Xiao, Victor Y Leung, William W Lu, Yong Hu, Keith D K Luk
PURPOSE: Fresh frozen intervertebral disc allograft transplantation has been reported to be a viable treatment option for advanced degenerative disc diseases, but rapid degeneration of the postoperative allograft was found. Loss of nutrient supply is believed to be the most likely inducer because the disc allografts have to endure in an ischaemic environment until the nutrient pathway is re-established. The aim of this study was to focus on the revascularisation of the disc allograft after transplantation in goats...
December 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29212437/k-rod-dynamic-internal-fixation-versus-microendoscopic-discectomy-for-the-treatment-of-single-segment-lumbar-disc-herniation
#8
Yang Qu, Meng Cheng, Rongpeng Dong, Mingyang Kang, Haohan Zhou, Jianwu Zhao
PURPOSE: This study compared the clinical outcome of K-rod dynamic internal fixation versus microendoscopic discectomy (MED) for the treatment of single-segment lumbar disc herniation. METHODS: This retrospective study included 34 patients with L4-L5 single-segment lumbar disc herniation who underwent K-rod dynamic internal fixation ( n = 18) or MED ( n = 16). The pain was evaluated by the Oswestry disability index (ODI) and visual analogue scale (VAS). The neurological function was assessed by the Japanese Orthopaedic Association (JOA) scores...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29208967/a-selective-inhibition-of-c-fos-activator-protein-1-as-a-potential-therapeutic-target-for-intervertebral-disc-degeneration-and-associated-pain
#9
Hiroto Makino, Shoji Seki, Yasuhito Yahara, Shunichi Shiozawa, Yukihiko Aikawa, Hiraku Motomura, Makiko Nogami, Kenta Watanabe, Takeshi Sainoh, Hisakatsu Ito, Noriyuki Tsumaki, Yoshiharu Kawaguchi, Mitsuaki Yamazaki, Tomoatsu Kimura
Intervertebral disc (IVD) degeneration is a major cause of low back pain. The transcription factor c-Fos/Activator Protein-1 (AP-1) controls the expression of inflammatory cytokines and matrix metalloproteinases (MMPs) that contribute to the pathogenesis IVD degeneration. We investigated the effects of inhibition of c-Fos/AP-1 on IVD degeneration and associated pain. A selective inhibitor, T-5224, significantly suppressed the interleukin-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription in human nucleus pulposus cells and in a mouse explant culture model of IVD degeneration...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208559/pilose-antler-peptide-attenuates-lps-induced-inflammatory-reaction
#10
Yu Dong, Li Liu, Xin Shan, Juanjuan Tang, Baomei Xia, Xiaolan Cheng, Yanyan Chen, Weiwei Tao
The present study was designed to study the effects of pilose antler peptide (PAP) on primary culture of nucleus pulposus cells in intervertebral disc. We demonstrated that PAP significantly inhibited lipopolysaccharides (LPS) induced over-production of inflammatory factors including interleukin-1β (IL-1β), tumor necrosis Factor-α (TNF-α) and interleukin-6 (IL-6) in nucleus pulposus cells. PAP also attenuated increase of malondialdehyde (MDA) and decrease of superoxide dismutase (SOD) induced by LPS challenge in a concentration-dependent manner...
December 2, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29207021/stromal-cell%C3%A2-derived-factor%C3%A2-1-induces-matrix-metalloproteinase-expression-in-human-endplate-chondrocytes-cartilage-endplate-degradation-in-explant-culture-and-the-amelioration-of-nucleus-pulposus-degeneration-in-vivo
#11
Hua Zhang, Ting Zhu, Li Zhang, Qionghua Wu
Intervertebral disc (IVD) degeneration is a strong etiological factor in chronic lower back pain. Stem cell migration toward the site of IVD degeneration for regeneration is restricted by avascularity and distance. Our previous study indicated that the expression of stromal cell‑derived factor‑1 (SDF‑1) and its receptor, C-X-C chemokine receptor type 4 (CXCR4) was upregulated in degenerated cartilage endplate (CEP) and nucleus pulposus (NP). In the present study, SDF‑1 increased CXCR4 mRNA and protein expression in human endplate chondrocytes in a dose‑dependent manner...
November 22, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29207013/effects-of-kartogenin-on-the-attenuated-nucleus-pulposus-cell-degeneration-of-intervertebral-discs-induced-by-interleukin-1%C3%AE-and-tumor-necrosis-factor-%C3%AE
#12
Yao Huang, Tao Jiang, Jian Chen, Guo-Yong Yin, Jin Fan
Cytokines are the main cause of intervertebral disc degeneration. Kartogenin (KGN) is found to protect chondrocytes from cytokines. To explore whether KGN can slow down the degeneration on intervertebral discs following exposure to interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF‑α), the expression of type II collagen (Col II) and aggrecan were detected by immunofluorescence, immunohistochemistry and tissue staining. An in vitro model of disc degeneration using human nucleus pulposus cells (hNPCs) and ex vivo culture of mouse intervertebral discs organs under the actions of inflammatory cytokines were used, and the expression of Col II and aggrecan in hNPCs were detected by semi-quantitative western blot analysis, and the mRNA expression of the genes than encode Col II and aggrecan were detected by reverse transcription‑quantitative polymerase chain reaction (RT-qPCR)...
November 24, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29204735/inflammaging-in-cervical-and-lumbar-degenerated-intervertebral-discs-analysis-of-proinflammatory-cytokine-and-trp-channel-expression
#13
Aleksandra Sadowska, Ermioni Touli, Wolfgang Hitzl, Helen Greutert, Stephen J Ferguson, Karin Wuertz-Kozak, Oliver N Hausmann
PURPOSE: To investigate and compare the occurrence of inflammatory processes in the sites of disc degeneration in the lumbar and cervical spine by a gene array and subsequent qPCR and to investigate the mechanistic involvement of transient receptor potential channels TRPC6 and TRPV4. METHODS: The gene expression of inflammatory cytokines and TRP channels was measured in human disc samples obtained from patients undergoing discectomy at the cervical (n = 24) or lumbar (n = 27) spine for degenerative disc disease (DDD) and disc herniation (DH) and analyzed for differences with regard to spinal level, IVD degeneration grade, Modic grade, age, sex, disc region and surgical extent...
December 4, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29203308/magnetic-resonance-imaging-undetectable-epiduroscopic-hotspot-in-chronic-discogenic-back-pain-does-sinuvertebral-neuropathy-actually-exists
#14
Sung Ho Choi, Nitin Adsul, Hyeun Sung Kim, Jee-Soo Jang, Il-Tae Jang, Seong-Hoon Oh
BACKGROUND: The causes of chronic discogenic back pain have not yet been clearly identified. Neural ingrowth around the annulus is widely considered to be one of the possible cause. However, neuropathy around the annulus has yet to be observed visually. We report a case of a hotspot that was observed in an epiduroscopic view, but not in imaging findings. CASE DESCRIPTION: A 46-year-old woman was admitted with pain in the back, left buttock, and posterior thigh for 2 years...
December 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29202505/incidence-of-abnormalities-of-the-second-and-third-cervical-vertebral-junction-in-dogs-with-atlantoaxial-instability-a-multicentre-study
#15
M Schneider, M Waschk, M C Precht, C Nathues, P Moissonnier, T Aikawa, D Schnötzinger, M Schmidt, D Garosi, F Forterre
Objective To evaluate the occurrence and frequency of abnormalities at the second and third cervical vertebral junction (C2/3) in dogs with and without atlantoaxial instability (AAI). Study Design Retrospective multi-institutional case-controlled case series. Animals One hundred and seventeen dogs with AAI and 117 dogs without AAI. Methods Radiographs, together with computer tomographic images or magnetic resonance images or both, of the cranial cervical spine of dogs were reviewed for the presence or absence of intervertebral disc-related anomalies, osseous fusion of the vertebrae, spondylosis, or any other anomaly of the C2/3...
November 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29201301/effects-of-different-angles-of-the-traction-table-on-lumbar-spine-ligaments-a-finite-element-study
#16
Hekmat Farajpour, Nima Jamshidi
Background: The traction bed is a noninvasive device for treating lower back pain caused by herniated intervertebral discs. In this study, we investigated the impact of the traction bed on the lower back as a means of increasing the disc height and creating a gap between facet joints. Methods: Computed tomography (CT) images were obtained from a female volunteer and a three-dimensional (3D) model was created using software package MIMICs 17.0. Afterwards, the 3D model was analyzed in an analytical software (Abaqus 6...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29201299/the-relationship-between-superior-disc-endplate-complex-injury-and-correction-loss-in-young-adult-patients-with-thoracolumbar-stable-burst-fracture
#17
Kyu Yeol Lee, Min-Woo Kim, Sang Yun Seok, Dong Ryul Kim, Chul Soon Im
Background: To determine the relationship between superior disc-endplate complex injury and correction loss after surgery in a group of young adult patients with a stable thoracolumbar burst fracture. Methods: The study group was comprised of young adult patients who had undergone short-segment posterior fixation and bone grafting under the diagnosis of a stable thoracolumbar burst fracture from March 2008 to February 2014. Follow-up was available for more than 1 year...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29199133/innovative-strategies-for-intervertebral-disc-regenerative-medicine-from-cell-therapies-to-multiscale-delivery-systems
#18
REVIEW
Nina Henry, Johann Clouet, Jean Le Bideau, Catherine Le Visage, Jérôme Guicheux
As our understanding of the physiopathology of intervertebral disc (IVD) degeneration has improved, novel therapeutic strategies have emerged, based on the local injection of cells, bioactive molecules, and nucleic acids. However, with regard to the harsh environment constituted by degenerated IVDs, protecting biologics from in situ degradation while allowing their long-term delivery is a major challenge. Yet, the design of the optimal approach for IVD regeneration is still under debate and only a few papers provide a critical assessment of IVD-specific carriers for local and sustained delivery of biologics...
November 30, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29197741/exploration-about-changes-of-il-10-nf-%C3%AE%C2%BAb-and-mmp-3-in-a-rat-model-of-cervical-spondylosis
#19
Jianjian Yin, Kewei Ren, Yongjing Huang, Gongming Gao, Luming Nong, Nanwei Xu
OBJECTIVES: To investigate the relationship and mechanism between IL-10, NF-κB and MMP-3 in cervical degenerative disease induced by unbalanced dynamic and static forces in rats. METHODS: Sixty Sprague Dawley rats were randomized into test (n=45) and control (n=15) groups, which were randomly subdivided into three groups corresponding to one-month, three-month and six-month post-operation. Test group included 10, 15, 20 rats at corresponding postoperative stage and control group had five rats at each time point...
November 30, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29196764/differences-in-trabecular-microarchitecture-and-simplified-boundary-conditions-limit-the-accuracy-of-qct-based-finite-element-models-of-vertebral-failure
#20
Amira I Hussein, Daniel Louzeiro, Ginu U Unnikrishnan, Elise F Morgan
Vertebral fractures are common in the elderly, but efforts to reduce their incidence have been hampered by incomplete understanding of the failure processes that are involved. This study's goal was to elucidate failure processes in the lumbar vertebra and to assess the accuracy of quantitative computed tomography (QCT)-based finite element (FE) simulations of these processes. Following QCT scanning, spine segments (n=27) consisting of L1 with adjacent intervertebral discs and neighboring endplates of T12 and L2 were compressed axially in a stepwise manner...
December 1, 2017: Journal of Biomechanical Engineering
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