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Albino Petrone, Flaminio Mormile, Giacomo Bruni, Michela Quartieri, Maria R Bonsignore, Oreste Marrone
OBJECTIVE: In obstructive sleep apnea (OSA), while both hypothyroidism and hyperthyroidism have been studied, the occurrence of non-thyroidal illness syndrome (NTIS) (normal thyroid stimulating hormone [TSH] with low triiodotironine) has not been investigated. We explored the occurrence of NTIS in patients with moderate to severe OSA and its relationship to the severity of nocturnal respiratory disorders. We also studied the occurrence of subclinical hypothyroidism (SH, ie, high TSH with normal thyroxine) in OSA and changes in circulating TSH, free triiodotironine (fT3) and free thyroxine (fT4) after CPAP treatment...
July 2016: Sleep Medicine
Güínever Eustáquio do Império, Isalira Peroba Ramos, Letícia Aragão Santiago, Guilherme Faria Pereira, Norma Aparecida dos Santos Almeida, Cesar Seigi Fuziwara, Carmen C Pazos-Moura, Edna Teruko Kimura, Emerson Lopes Olivares, Tania Maria Ortiga-Carvalho
BACKGROUND/AIMS: Thyroid hormone (TH) signalling is critical for heart function. The heart expresses thyroid hormone receptors (THRs); THRα1 and THRβ1. We aimed to investigate the regulation mechanisms of the THRβ isoform, its association with gene expression changes and implications for cardiac function. METHODS: The experiments were performed using adult male mice expressing TRβΔ337T, which contains the Δ337T mutation of the human THRB gene and impairs ligand binding...
2015: Cellular Physiology and Biochemistry
Monica A Ercolano, Monica L Drnovsek, Maria C Silva Croome, Monica Moos, Ana M Fuentes, Fanny Viale, Ulla Feldt-Rasmussen, Alicia T Gauna
BACKGROUND: Thyrotoxicosis is a cause of secondary osteoporosis. High concentrations of triiodotironine (T3) in Graves' disease stimulate bone turnover, but it is unclear if euthyroidism will always normalize bone metabolism. Thyrotropin (TSH) is known to affect directly the bone metabolism through the TSH receptor and TSH receptor antibodies (TRAb) may have an important role in bone turn-over.The aim of our study was to determine, in pre and postmenopausal euthyroidism patients with previous overt hyperthyroidism due to Graves' disease the bone mineral density (BMD) as well as factors that could affect BMD in each group, including TRAb...
September 11, 2013: Thyroid Research
C S Bittencourt, A E C S Azzolini, D A Ferreira, A I Assis-Pandochi
This study evaluated antibody production against sheep red blood cells (SRBC) in hyperthyroid rats during treatment with triiodothyronine (T(3)). The immune response was evaluated by measuring plaque forming cells (PFC) in the spleen and by enzyme-linked immunosorbent assay (ELISA) in serum of male Wistar rats (180+/-10 g) treated with 25 mug/day of triiodotironine (T(3)) during 7-12 days and immunized with SRBC at the 8th day of treatment. The results showed that anti-SRBC antibody production was significantly decreased in animals treated for 12 days when compared to normal rats immunized with the same antigen, as evaluated by the two assays...
July 2007: International Immunopharmacology
Fabrizio Aghini-Lombardi, Aghini-Lombardi Fabrizio, Vitantonio Di Bello, Di Bello Vitantonio, Enrica Talini, Talini Enrica, Andrea Di Cori, Di Cori Andrea, Fabio Monzani, Monzani Fabio, Lucia Antonangeli, Antonangeli Lucia, Caterina Palagi, Palagi Caterina, Nadia Caraccio, Caraccio Nadia, Maria Grazia Delle Donne, Delle Donne Maria Grazia, Carmela Nardi, Nardi Carmela, Angela Dardano, Dardano Angela, Alberto Balbarini, Balbarini Alberto, Mario Mariani, Mariani Mario, Aldo Pinchera, Pinchera Aldo
The aim of the present study was to evaluate cardiac function and texture in patients with subclinical hypothyroidism (sHT) both by conventional and new ultrasonic intramyocardial tissue techniques. sHT was characterized by normal serum free tetraiodotironine and free triiodotironine levels and slightly increased serum TSH level. Twenty-four patients affected by sHT and 24 sex- and age-matched healthy volunteers were studied. All subjects were submitted to conventional two-dimensional (2D)-color Doppler echocardiography, pulsed wave tissue Doppler imaging (PWTDI) for the analysis of the diastolic function, color Doppler myocardial imaging (CDMI) for the analysis of regional strain and strain-rate and integrated backscatter (IBS) for the evaluation of intrinsic contractility and tissue characterization...
July 2006: European Journal of Endocrinology
I Bucci, G Napolitano, C Giuliani, S Lio, A Minnucci, F Di Giacomo, G Calabrese, G Sabatino, G Palka, F Monaco
In subjects affected by trisomy 21 (Down syndrome), hypothyroidism is the most common endocrinological deficit. Plasma zinc levels, which are commonly detected below the normal range in Down patients, are related to some endocrinological and immunological functions; in fact, zinc deficiency has been shown to impair immune response and growth rate. Aims of this study were to evaluate (1) the role of zinc deficiency in subclinical hypothyroidism and (2) thyroid function changes in Down children cyclically supplemented with zinc sulfate...
March 1999: Biological Trace Element Research
I Orden, J Pié, M G Juste, A Giner, M E Gómez, J F Escanero
The purpose of this work was to estimate the 24 h urinary excretion of free and conjugated triiodotironine (T3) using a direct radioimmunoassay and enzyme hydrolysis. Mean urinary values of free and total T3 (mean +/- 1 SD) in euthyroid controls were 2074 +/- 673 and 2819 +/- 809 pmol/24 h respectively. In patients with hyperthyroidism, values of free hormone were about 4.2 times higher than the mean value of the euthyroid controls, and about one-third in patients with hypothyroidism. These results show this measurement to be useful as an indicator of thyroid function...
June 1988: Revista Española de Fisiología
M Terzolo, A Piovesan, B Puligheddu, M Torta, G Osella, P Paccotti, A Angeli
Six healthy adult male volunteers underwent serial blood drawings at 4-hour intervals over 24 hours for the definition of melatonin (MT), prolactin (PRL), cortisol, and testosterone circadian patterns. Serum levels of triiodotironine (T3) and thyroxine (T4) were determined at 0800. Systolic and diastolic blood pressure and heart rate were automatically recorded every 30 minutes for 24 hours. The responses of luteinizing hormone (LH), follicle stimulating hormone (FSH), PRL, thyroid stimulating hormone (TSH), cortisol, and aldosterone to a stimulation test with gonadotrophin-releasing hormone (Gn-RH), thyrotrophin-releasing hormone (TRH), adrenocorticotrophin (ACTH), and testosterone to human chorionic gonadotrophin (HCG) were also evaluated...
1990: Journal of Pineal Research
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