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Arteriovenous Malformations

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https://www.readbyqxmd.com/read/29444560/cohort-studies-trials-and-tribulations-systematic-review-and-an-evidence-based-approach-to-avm-treatment
#1
Mary Simons, Michael K Morgan, Andrew S Davidson
INTRODUCTION: There is uncertainty as to the best management of arteriovenous malformations of the brain (bAVM). However, the Spetzler-Martin grade (SMG) has been validated as an effective determinant of surgical risks. We performed a systematic review for the best evidence regarding the management of bAVM for series that incorporate an analysis based upon SMG. EVIDENCE ACQUISITION: Medline, Embase, Scopus and Cochrane databases were searched for series between January 2000 and January 2018, with a minimum of 100 cases and that incorporated SMG stratification...
February 13, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29444556/transvenous-embolization-of-brain-arteriovenous-malformations-a-systematic-review-and-meta-analysis
#2
Yi-Bin Fang, Jun-Soo Byun, Jian-Min Liu, Timo Krings, Vitor M Pereira, Waleed Brinjikji
INTRODUCTION: The safety and efficacy of transvenous embolization of brain arteriovenous malformations (AVM) remains relatively poorly understood. We performed a systematic review of the literature to determine outcomes of transvenous embolization of brain AVMs. EVIDENCE ACQUISITION: Data Sources include Ovid MEDLINE, Ovid EMBASE and the Web of Science. All case series with ≥4 patients receiving transvenous embolization of brain AVMs published through September 2017 were included...
February 13, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29444212/loss-of-function-mutations-in-ephb4-are-responsible-for-vein-of-galen-aneurysmal-malformation
#3
Alexandre Vivanti, Augustin Ozanne, Cynthia Grondin, Guillaume Saliou, Loic Quevarec, Helène Maurey, Patrick Aubourg, Alexandra Benachi, Marta Gut, Ivo Gut, Jelena Martinovic, Marie Victoire Sénat, Marcel Tawk, Judith Melki
Vein of Galen aneurysmal malformation is a congenital anomaly of the cerebral vasculature representing 30% of all paediatric vascular malformations. We conducted whole exome sequencing in 19 unrelated patients presenting this malformation and subsequently screened candidate genes in a cohort of 32 additional patients using either targeted exome or Sanger sequencing. In a cohort of 51 patients, we found five affected individuals with heterozygous mutations in EPHB4 including de novo frameshift (p.His191Alafs*32) or inherited deleterious splice or missense mutations predicted to be pathogenic by in silico tools...
February 9, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29440838/arterial-duct-and-pulmonary-arteriovenous-malformations-a-shunt-masking-a-shunt
#4
Mario Giordano, Giuseppe Santoro, Maria Teresa Palladino, Maria Giovanna Russo
A 5-month-old infant, referred to our institution for percutaneous arterial duct (AD) embolization, showed multiple huge pulmonary arteriovenous malformations (PAVMs) associated with a small AD and several tiny systemic-to-pulmonary collaterals. This anatomic arrangement was a possible cause of lack of cyanosis and disproportionately higher hemodynamic relevance of the ductal shunt. The PAVMs became pathophysiologically evident immediately after the closure of AD and systemic to pulmonary artery collaterals and presented clinically with a life-threatening cyanosis...
January 2018: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/29438587/managing-penetrating-renal-trauma-experience-from-two-uk-major-trauma-centres
#5
Marios Hadjipavlou, Edmund Grouse, Robert Gray, Denosshan Sri, Dean Huang, Christian Brown, Davendra Sharma
OBJECTIVES: To present our series of patients with penetrating renal trauma from two urban major trauma centres and discuss contemporary management of these injuries. METHODS: We reviewed prospective urological trauma databases for all patients presenting with penetrating renal trauma between January 2005 and October 2016. Patient demographics, clinical characteristics, imaging, management and follow-up data were analysed. RESULTS: Over the 11 year period, 63 patients presented with penetrating renal injuries...
February 13, 2018: BJU International
https://www.readbyqxmd.com/read/29438260/endothelial-cell-biology-of-endoglin-in-hereditary-hemorrhagic-telangiectasia
#6
Wade W Sugden, Arndt F Siekmann
PURPOSE OF REVIEW: Mutations in the Endoglin (Eng) gene, an auxiliary receptor in the transforming growth factor beta (TGFβ)-superfamily signaling pathway, are responsible for the human vascular disorder hereditary hemorrhagic telangiectasia (HHT) type 1, characterized in part by blood vessel enlargement. A growing body of work has uncovered an autonomous role for Eng in endothelial cells. We will highlight the influence of Eng on distinct cellular behaviors, such as migration and shape control, which are ultimately important for the assignment of proper blood vessel diameters...
February 12, 2018: Current Opinion in Hematology
https://www.readbyqxmd.com/read/29436856/chondroitinase-abc-for-neurological-recovery-after-acute-brain-injury-systematic-review-and-meta-analyses-of-preclinical-studies
#7
Chan Hee Koh, Savva Pronin, Mark Hughes
OBJECTIVES: Damage to critical brain regions causes deficits in important neurological functions. Chondroitinase ABC (ChABC) has been shown to promote neuroplasticity and may ameliorate neurological deficits caused by disease or trauma. This systematic review identifies and evaluates preclinical studies of ChABC as a treatment for acute brain injury. METHODS: Four databases were searched for studies relating to ChABC and brain or brain injuries. Controlled studies in mammals with acute brain injuries treated with ChABC were included in meta-analyses of neurobehavioural outcomes...
February 13, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29433331/pseudoaneurysm-formation-and-rupture-after-stereotactic-radiotherapy-for-cerebral-arteriovenous-malformation-a-case-report-and-review-of-literature
#8
Anderson Chun On Tsang, Derek Ping Hong Wong, Wah Cheuk, Kam Fuk Fok
We report a rare delayed complication of de novo pseudoaneurysm formation and rupture after stereotactic radiotherapy for cerebral arteriovenous malformation. The patient presented with intracerebral haemorrhage due to rupture of a pseudoaneurysm in the previously irradiated field, which was excised for histological examination. The literature was reviewed for similar cases.
February 12, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29432871/tertiary-referral-hospital-experiences-of-men-presenting-with-painless-post-coital-gross-hematuria-and-a-suggestion-for-the-management-algorithm
#9
Dong Hyuk Kang, Joo Yong Lee, Dae Chul Jung, Young Taik Oh, Eun Suk Cho, Sung Yoon Park, Ki Soo Lee, Kang Su Cho
OBJECTIVE: To review the tertiary referral hospital experiences of men presenting with painless post-coital gross hematuria (PCGH) and suggest the management algorithm. MATERIALS AND METHODS: We reviewed clinical data from 19 male patients who first visited a clinic because of PCGH between 2009 and 2016. The patients were evaluated according to our tentative management algorithm for painless PCGH. First, a general work-up for painless gross hematuria (GH) was performed...
February 9, 2018: Urology
https://www.readbyqxmd.com/read/29429141/utility-of-second-generation-single-energy-metal-artifact-reduction-in-helical-lung-computed-tomography-for-patients-with-pulmonary-arteriovenous-malformation-after-coil-embolization
#10
Yudai Asano, Akihiro Tada, Takayoshi Shinya, Yoshihisa Masaoka, Toshihiro Iguchi, Shuhei Sato, Susumu Kanazawa
PURPOSE: The quality of images acquired using single-energy metal artifact reduction (SEMAR) on helical lung computed tomography (CT) in patients with pulmonary arteriovenous malformation (PAVM) after coil embolization was retrospectively evaluated. MATERIALS AND METHODS: CT images were reconstructed with and without SEMAR. Twenty-seven lesions [20 patients (2 males, 18 females), mean age 61.2 ± 11.0 years; number of embolization coils, 9.8 ± 5.0] on contrast-enhanced CT and 18 lesions of non-enhanced lung CT concurrently performed were evaluated...
February 10, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29424187/vascular-malformations-classification-diagnosis-and-treatment
#11
Inês M Carqueja, Joel Sousa, Armando Mansilha
BACKGROUND: Vascular malformations are congenital lesions with complex clinical presentations and management. Their classification and treatment options have considerably changed throughout the years, with conflicting evidence in the literature. In this article, we aim to review the classification, diagnosis and treatment of the main vascular malformations. METHODS: A thorough non-systematic review of the literature was conducted using PubMed/Medline. Seventy-nine articles were selected and included, according to their scientific relevance and relation with the subject...
February 8, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29423315/temporal-evolution-of-a-patient-with-a-spinal-dural-arteriovenous-fistula-on-serial-mri
#12
Michael G Kim, Seung W Jeong, Elena Solli, Anubhav G Amin, Jennifer S Ronecker, Shalabh Bobra
Introduction: A spinal dural arteriovenous fistula is a rare type of vascular malformation. If left untreated, these fistulas can result in significant neurological deficits secondary to spinal cord infarct or hemorrhage. Case presentation: A 70-year-old female with a longstanding history of episodic progressive bilateral lower extremity weakness and sensory disturbances was previously misdiagnosed with multiple sclerosis. Imaging revealed a T2 signal change from T7 to the conus with associated signal change and she subsequently underwent a T10-L1 laminectomy for clip ligation of a spinal dural arteriovenous fistula...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29417325/preoperative-right-sided-cardiac-congestion-is-associated-with-gastrointestinal-bleeding-in-patients-with-continuous-flow-left-ventricular-assist-devices
#13
Yutaka Tomizawa, Akiko Tanaka, Hiroto Kitahara, Atsushi Sakuraba, Nir Uriel, Valluvan Jeevanandam, Takeyoshi Ota
BACKGROUND: Large scale data on preoperative risk stratification for gastrointestinal bleeding (GIB) following continuous-flow left ventricular assist device (CF-LVAD) implantation are scarce. AIMS: To identify independent predictors for GIB following CF-LVAD implantation. METHODS: We conducted a retrospective cohort study of consecutive 243 patients who underwent CF-LVAD implantation (HeartMateII) from January 2009 to March 2015 at the University of Chicago Medical Center...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29417264/polidocanol-sclerotherapy-combined-with-transarterial-embolization-using-n-butyl-cyanoacrylate-for-extracranial-arteriovenous-malformations
#14
Akira Kitagawa, Takahiro Yamamoto, Nozomu Matsunaga, Mayako Yamaji, Shuji Ikeda, Yuichiro Izumi, Makiyo Hagihara, Toyohiro Ota, Tsuneo Ishiguchi
PURPOSE: To assess the safety and effectiveness of polidocanol sclerotherapy combined with transarterial embolization using a liquid adhesive agent (n-butyl cyanoacrylate, NBCA) for treatment of extracranial arteriovenous malformations (AVMs). MATERIALS AND METHODS: Twenty-three patients with symptomatic AVMs in the head and neck (6), upper (7) and lower extremity (10) with a mean age of 42 years (range 4-74) treated with polidocanol sclerotherapy were retrospectively assessed...
February 7, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29415296/vascular-anomalies-part-ii-interventional-therapy-of-peripheral-vascular-malformations
#15
René Müller-Wille, Moritz Wildgruber, Maliha Sadick, Walter A Wohlgemuth
BACKGROUND:  The International Society for the Study of Vascular Anomalies (ISSVA) categorizes vascular anomalies into vascular tumors and vascular malformations. Vascular malformations are further divided into slow-flow (venous, lymphatic, and capillary malformation) and fast-flow malformations (arteriovenous malformation and arteriovenous fistula). This interdisciplinary classification has therapeutic implications. METHODS:  The objective of this article is to provide concise information about the current terminology and treatment strategies of peripheral vascular malformations, based on the currently available literature, with a focus on interventional therapy of venous malformations (VM), lymphatic malformations (LM), arteriovenous malformations (AVM) and arteriovenous fistulae (AVF)...
February 7, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29410371/trans-venous-embolization-of-a-basal-ganglia-ruptured-arteriovenous-malformation-with-open-surgical-arterial-control-a-hybrid-technique
#16
Zsolt Kulcsár, Paolo Machi, Karl Schaller, Karl Olof Lovblad, Philippe Bijlenga
Treatment of ruptured deep-seated arteriovenous malformations is challenging and associated with elevated risks. This is due to the proximity or involvement of critical brain structures and the specifically fine and delicate angioarchitecture of these lesions, making both endovascular and surgical access technically complicated. We present the advantages of a true combined, open surgical and endovascular transvenous approach in a hybrid operating room. The technique may overcome in part the difficulties and may improve safety and risk related concerns...
February 1, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29406356/gastrointestinal-bleeding-in-left-ventricular-assist-device-octreotide-and-other-treatment-modalities
#17
Tara L Molina, Jill Krisl, Kevin Donahue, Sara Varnado
Left ventricular assist devices (LVADs) offer a therapeutic strategy for patients with end-stage heart failure. Increased device utilization has also increased the incidence of device-related complications including gastrointestinal bleeding (GIB). Multiple mechanisms have been proposed in the pathophysiology of continuous-flow LVAD-associated GIB including physiologic changes associated with high shear and nonpulsatile flow such as gastrointestinal arteriovenous malformations and acquired von Willebrand syndrome...
February 5, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29405446/role-of-hemostatic-powders-in-the-management-of-lower-gastrointestinal-bleeding-a-review
#18
REVIEW
Fadi H Mourad, Rupert W Leong
Despite the recent advances in endoscopic hemostatic techniques, the management of lower gastrointestinal bleeding could be sometimes challenging. Hemostatic powders such as hemospray, endoclot and Ankafred Blood Stopper have found their way into digestive endoscopy and are licenced in many countries especially for use in upper gastrointestinal bleeding. We reviewed the literature on the use of these hemostatic powders in different situations in lower gastrointestinal bleeding and looked at the success rate and rebleeding rate...
February 6, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29404916/a-case-of-pancreatic-av-malformation-in-an-elderly-man
#19
Vipin Gupta, Saurabh Kedia, Ujjwal Sonika, Kumble Seetharama Madhusudhan, Sujoy Pal, Pramod Garg
A 60-year-old man presented with recurrent abdominal pain and weight loss for 6 months. Abdominal imaging showed a large vascular lesion in the head and neck of pancreas suggestive of arteriovenous malformation (AV malformation). Endoscopic ultrasound was done which showed features of AV malformation with no evidence of pancreatic malignancy. Surgery was planned for definitive treatment of malformation. Digital subtraction angiography with angioembolization was done prior to surgery to reduce vascularity of the lesion...
February 5, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29402604/limited-usefulness-of-endoscopic-evaluation-in-patients-with-continuous-flow-left-ventricular-assist-devices-and-gastrointestinal-bleeding
#20
Jordan E Axelrad, Alberto Pinsino, Pauline N Trinh, Anusorn Thanataveerat, Christian Brooks, Ryan T Demmer, Lisa Effner, Grant Parkis, Barbara Cagliostro, Jiho Han, A Reshad Garan, Veli Topkara, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Ivonne Ramirez, Reuben Garcia-Carrasquillo, Paolo C Colombo, Tamas Gonda, Melana Yuzefpolskaya
BACKGROUND: Gastrointestinal bleeding (GIB) is a frequent cause of re-admission in patients with continuous-flow left ventricular assist devices (CF-LVADs) and is associated with multiple endoscopic procedures and high resource utilization. Our aim was to determine the diagnostic and therapeutic yield of endoscopy and to develop a more cost-effective approach for the management of GIB in CF-LVAD recipients. METHODS: We retrospectively reviewed 428 patients implanted with a CF-LVAD between 2009 and 2016 at the Columbia University Medical Center and identified those hospitalized for GIB...
December 20, 2017: Journal of Heart and Lung Transplantation
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