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https://www.readbyqxmd.com/read/29352651/catheter-injected-bone-marrow-mesenchymal-stem-cells-induce-efficacious-occlusion-of-arteriovenous-nidus-in-a-swine-model
#1
Joseph Touma, Jianping Dai, Andre Gaston, Marianne Gervais, Eric Allaire
OBJECTIVES: Arteriovenous malformations (AVMs) are complex vascular lesions. Surgical excision is the treatment of choice, but is often not achievable. Embolo-sclerotherapy alone is associated with high recurrence rates. This study tested the hypothesis that seeding hydrogel conditioned bone marrow derived mesenchymatous stem cells (BM-MSCs) in an AVM nidus model induces solid microvascular occlusion through endoluminal tissue growth. METHODS: AVMs were modelled as arteriovenous microvascular nidus, using swine rete mirabile, a plexiform intracranial structure composed of arterial microvessels that extensively anastomose...
January 15, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29352055/concomitant-conus-medullaris-arteriovenous-shunts-and-sacral-dural-arteriovenous-fistulas-pathophysiological-links-related-to-the-venous-drainage-of-the-lesions-in-a-series-of-five-cases
#2
Andrea Rosi, Arturo Consoli, Stéphanie Condette-Auliac, Oguzhan Coskun, Federico Di Maria, Georges Rodesch
BACKGROUND: Spinal cord arteriovenous shunts (scAVSs) are a group of lesions located in the spinal cord itself or in the surrounding structures. The most common scAVSs are spinal dural arteriovenous fistulas (sDAVFs), which are acquired lesions. The pathogenesis of sDAVFs involves thrombosis and venous hypertension as trigger factors. Intradural scAVSs such as spinal cord arteriovenous nidus type malformations (AVMs) and pial arteriovenous fistulas are less common than sDAVFs and are considered to have a so-called 'congenital' origin...
January 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29351691/out-of-field-doses-in-children-treated-for-large-arteriovenous-malformations-using-hypofractionated-gamma-knife-radiosurgery-and-intensity-modulated-radiation-therapy
#3
Marijke De Saint-Hubert, Marija Majer, Hrvoje Hršak, Zdravko Heinrich, Željka Kneževic, Saveta Miljanic, Paulina Porwol, Liliana Stolarczyk, Filip Vanhavere, Roger M Harrison
The purpose of this study was to measure out-of-field organ doses in two anthropomorphic child phantoms for the treatment of large brain arteriovenous malformations (AVMs) using hypofractionated gamma knife (GK) radiosurgery and to compare these with an alternative treatment using intensity-modulated radiation therapy (IMRT). Target volume was identical in size and shape in all cases. Radiophotoluminescent (RPL), thermoluminescent (TL) and optically stimulated luminescent (OSL) dosimeters were used for out-of-field dosimetry during GK treatment and a good agreement within 1-2% between results was shown...
January 17, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29334259/development-of-three-dimensional-brain-arteriovenous-malformation-model-for-patient-communication-and-young-neurosurgeon-education
#4
Mengqi Dong, Guangzhong Chen, Kun Qin, Xiaowen Ding, Dong Zhou, Chao Peng, Shaojian Zeng, Xianming Deng
PURPOSE: Rapid prototyping technology is used to fabricate three-dimensional (3D) brain arteriovenous malformation (AVM) models and facilitate presurgical patient communication and medical education for young surgeons. METHODS: Two intracranial AVM cases were selected for this study. Using 3D CT angiography or 3D rotational angiography images, the brain AVM models were reconstructed on personal computer and the rapid prototyping process was completed using a 3D printer...
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29322721/mandibular-av-malformation-a-rare-cause-of-massive-bleeding-from-mouth-managed-with-multiple-vessel-embolization
#5
Rajeev Bhardwaj, Rajesh Sharma
An arteriovenous malformation (AVM) is a site of abnormal connectivity between arteries and veins. Arteriovenous malformations of jaw are extremely rare conditions that can result in disastrous complications, if handled carelessly. Although various treatment modalities have been advocated in the literature, there seems to be no complete consensus on a suitable treatment in these cases. We describe a case of mandibular AVM, who presented with massive bleeding from mouth and each time, embolization of one vessel was done, it recruited new vessel...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29303444/reductions-in-brain-pericytes-are-associated-with-arteriovenous-malformation-vascular-instability
#6
Ethan A Winkler, Harjus Birk, Jan-Karl Burkhardt, Xiaolin Chen, John K Yue, Diana Guo, W Caleb Rutledge, George F Lasker, Carlene Partow, Tarik Tihan, Edward F Chang, Hua Su, Helen Kim, Brian P Walcott, Michael T Lawton
OBJECTIVE Brain arteriovenous malformations (bAVMs) are rupture-prone tangles of blood vessels with direct shunting of blood flow between arterial and venous circulations. The molecular and/or cellular mechanisms contributing to bAVM pathogenesis and/or destabilization in sporadic lesions have remained elusive. Initial insights into AVM formation have been gained through models of genetic AVM syndromes. And while many studies have focused on endothelial cells, the contributions of other vascular cell types have yet to be systematically studied...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29295765/absolute-ethanol-embolization-combined-with-surgical-resection-of-scalp-arteriovenous-malformations-interim%C3%A2-results
#7
Yifeng Han, Xindong Fan, Lixin Su, Zhenfeng Wang
PURPOSE: To assess treatment methods, interim results, and complications of absolute ethanol embolization combined with surgical resection of scalp arteriovenous malformations (AVMs). MATERIALS AND METHODS: From September 2012 to January 2015, 15 consecutive patients (8 male and 7 female) with scalp AVMs underwent staged ethanol embolizations. Ethanol embolization was performed using transcatheter and/or direct puncture techniques. Ten patients with scalp AVMs with a dominant outflow vein (DOV) also underwent coil deployment before ethanol embolization...
December 30, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29291536/skeletonization-method-for-vessel-delineation-of-arteriovenous-malformation
#8
D Babin, A Pižurica, L Velicki, V Matić, I Galić, H Leventić, V Zlokolica, W Philips
Cerebral arteriovenous malformation (AVM) presents a great health threat due to its high probability of rupture that can cause severe brain damage. Image segmentation alone is not sufficient to support AVM embolization procedure. In order to successfully navigate the catheter and perform embolization, the segmented blood vessels need to be classified into feeding arteries, draining veins and the AVM nidus. For this reason we address here the AVM localization and vessel decomposition problem. We propose in this paper a novel AVM localization and vessel delineation method using ordered thinning-based skeletonization...
December 19, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29283148/combined-approach-to-management-of-periocular-arteriovenous-malformation-by-interventional-radiology-and-surgical-excision
#9
Bipasha Mukherjee, Vathsalya Vijay, Swatee Halbe
Periorbital arteriovenous malformations (AVMs) are congenital lesions that may cause significant morbidity such as amblyopia, cosmetic disfigurement, or chronic pain. Due to the rarity of these lesions, they are frequently misdiagnosed and treated inappropriately. We managed a 6-year-old girl with preseptal AVM by endovascular embolization followed by complete surgical excision after 2 days. She was previously diagnosed as capillary hemangioma and was being treated with intralesional steroid injections and oral propranolol...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29281075/transvenous-curative-embolization-of-cerebral-arteriovenous-malformations-a-prospective-cohort-study
#10
George A C Mendes, M Yashar S Kalani, Christina Iosif, Adson F Lucena, Rui Carvalho, Suzana Saleme, Charbel Mounayer
BACKGROUND: Curative transvenous embolization is an emerging strategy for treatment of cerebral arteriovenous malformations (AVMs). OBJECTIVE: To assess contemporary outcomes of transvenous embolization as a stand-alone therapy for cerebral AVMs. METHODS: We prospectively followed 40 patients with 41 AVMs who underwent transvenous endovascular therapy between January 2008 and January 2015. Patient demographics, AVM characteristics, endovascular techniques used, angiographic results, clinical outcomes, and complications were assessed independently...
December 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29274362/a-new-time-resolved-3d-angiographic-technique-4d-dsa-description-and-assessment-of-its-reliability-in-spetzler-martin-grading-of-cerebral-arteriovenous-malformations
#11
Julien Ognard, Elsa Magro, Jildaz Caroff, Douraied Ben Salem, Sebastien Andouard, Michel Nonent, Jean-Christophe Gentric
BACKGROUND AND PURPOSE: The Spetzler and Martin (SM) cerebral arteriovenous malformation (AVM) classification is a widely used 5-tier classification. This common language allows specialists to exchange about AVMs and must be reliably characterized by the imaging methods. We presented an agreement study on a new method of digital subtracted 3D rotational angiography resolved in time (four-dimensional DSA: 4D DSA) compared to the gold standard (two-dimensional digital DSA: 2D DSA) in AVM grading using the SM classification...
December 20, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29258932/rupture-risk-of-cerebral-arteriovenous-malformations-during-pregnancy-and-puerperium-a-single-center-experience-and-pooled-data-analysis
#12
Deyuan Zhu, Puyuan Zhao, Nan Lv, Qiang Li, Yibin Fang, Zhe Li, Hongjian Zhang, Guoli Duan, Bo Hong, Yi Xu, Jianmin Liu, Qinghai Huang
BACKGROUND AND PURPOSE: Whether the rupture risk of cerebral arteriovenous malformation (AVM) is higher during pregnancy and puerperium remains controversial. This study aimed to compare the risk of rupture in pregnant and non-pregnant female patients with AVM in a singer-center series and assess current evidence regarding the rupture risk of AVM during pregnancy and puerperium by pooled data analysis. METHODS: We retrospectively reviewed female patients with AVM in our center from January 2006 to August 2017...
December 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29249075/the-characteristics-of-transcranial-color-coded-duplex-sonography-in-children-with-cerebral-arteriovenous-malformation-presenting-with-headache
#13
Vlasta Duranovic, Katarina Vulin, Ivana Dakovic, Jasna Lenicek Krleza, Sanja Delin, Ivana Galinovic, Josip Marjanovic, Ana Tripalo Batos, Zdenka Plesa Premilovac, Vlatka Mejaski Bosnjak
PURPOSE: Cerebral arteriovenous malformations (AVM) are uncommon lesions. They are most often presented in childhood as intracranial hemorrhage. The aim of this report is to present the use of transcranial color-coded duplex sonography (TCCS) in detection of AVMs in children suffering headache. METHODS: This report describes five pediatric patients with headache and cerebral AVM which were initially discovered by TCCS. Diagnosis was confirmed by magnetic resonance imaging and digital subtraction angiography...
December 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29248377/management-of-a-complex-intracranial-arteriovenous-malformation-with-gamma-knife-radiosurgery-a-case-report-with-review-of-literature
#14
Shyamal C Bir, Subhas K Konar, Devi P Patra, Tanmoy K Maiti, Alireza Minagar, Anil Nanda
The risks and benefits of arteriovenous malformation (AVM) treatment should be considered cautiously in each patient since management strategy of it depends on various factors including age of the patient, location and volume of AVM and presence of other vascular abnormalities. Current management options of AVM include observation, endovascular embolization, radiosurgery and microsurgical resection or in combination of any two of the above procedures. Here, we have discussed a case of intracranial AVM with radiation induced early cyst formation, and performed a literature review to determine the optimum treatment of complex intracranial AVM...
December 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29245106/cerebral-arterio-venous-malformations-in-the-paediatric-population-angiographic-characteristics-multimodal-treatment-strategies-and-outcome
#15
Klaus-Peter Stein, Bernd-Otto Huetter, Sophia Goericke, Neriman Oezkan, Rebecca Leyrer, I Erol Sandalcioglu, Michael Forsting, Ulrich Sure, Oliver Mueller
OBJECTIVES: Cerebral arterio-venous malformations (AVM) are considered congenital lesions, emerging as an important cause of haemorrhagic stroke in children. The potential influence of age on clinical presentation and angio-architecture have been analysed extensively in the last years. Yet, comparative studies comprising ascending age groups may be limited in their conclusions, especially when comparing young children and adults. It is the aim of this study to evaluate characteristic clinical and angiographic features of AVM within a paediatric subgroup and their correlation to age at presentation...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29237147/treatment-of-early-stage-extracranial-arteriovenous-malformations-with-intralesional-interstitial-bleomycin-injection-a-pilot-study
#16
Yunbo Jin, Yun Zou, Chen Hua, Hui Chen, Xi Yang, Gang Ma, Lei Chang, Yajing Qiu, Dongze Lyu, Tianyou Wang, Shih-Jen Chang, Congzhen Qiao, Chunfen Luo, Mathias Tremp, Xiaoxi Lin
Purpose To assess the efficacy and safety of intralesional interstitial bleomycin injection in the treatment of early-stage (Schobinger stage I or II) extracranial arteriovenous malformations (AVMs). Materials and Methods This prospective study involved 34 patients with early-stage AVMs, as defined by the Schobinger staging system. The patients received intralesional interstitial bleomycin injected at a maximum dose of 15 000 IU or 1000 IU per kilogram of body weight for children who weighed less than 15 kg per procedure for a total of 6 months (once every month)...
December 13, 2017: Radiology
https://www.readbyqxmd.com/read/29232026/noncontrast-enhanced-time-resolved-4d-dynamic-intracranial-mr-angiography-at-7t-a-feasibility-study
#17
Fei Cong, Yan Zhuo, Songlin Yu, Xianchang Zhang, Xinyuan Miao, Jing An, Shuo Wang, Yong Cao, Yan Zhang, Hee Kwon Song, Danny Jj Wang, Lirong Yan
BACKGROUND: Arterial spin labeling (ASL) based-noncontrast-enhanced 4D MR angiography (NCE 4D MRA) shows potential in characterizing cerebrovascular hemodynamics in cerebrovascular disorders. Ultrahigh-field theoretically benefits ASL signal with increased inherent signal-to-noise ratio (SNR) and prolonged blood T1 , which may provide improved delineation of vasculature in 4D MRA. PURPOSE: To investigate the feasibility of NCE 4D MRA using 3D Cartesian trajectory and stack-of-stars (SOS) golden angle radial trajectory at 7T...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29221921/ethanol-embolotherapy-for-the-management-of-refractory-chronic-skin-ulcers-caused-by%C3%A2-arteriovenous-malformations
#18
YunBo Jin, Xi Yang, Chen Hua, XiaoXi Lin, Hui Chen, Gang Ma, TianYou Wang, WenXin Yu
PURPOSE: To describe the clinical features and treatment outcomes of ethanol embolotherapy in refractory chronic skin ulcers caused by arteriovenous malformations (AVMs). MATERIALS AND METHODS: From October 2011 to October 2015, 12 patients (5 male; mean age, 26.2 y) with refractory chronic skin ulcers caused by AVMs were treated at a single institution. Ethanol embolotherapy was performed by direct puncture techniques. Needles were directly inserted toward the nidus of the lesion based on imaging analysis...
January 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29217062/arteriovenous-malformations-of-the-head-and-neck
#19
REVIEW
Tara L Rosenberg, James Y Suen, Gresham T Richter
Extracranial arteriovenous malformations (AVMs) are complex vascular malformations to diagnose and treat. They are comprised of congenitally derived arteriovenous shunts with chronic vascular expansion, collateralization, and infiltration of local tissue. Their cause remains unclear, but new genetic and molecular clues are emerging. They may present at any age following an early quiescent period. Diagnosis is based on vascular staining, soft tissue expansion, progressive growth, warmth, and pulsations. Focal lesions can be cured, whereas diffuse AVMs demonstrate highly recidivistic disease...
February 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29216502/intraventricular-hemorrhage-related-to-avm-rupture-description-outcomes-and-impact-of-intraventricular-fibrinolysis
#20
Vianney Gilard, Thomas Metayer, Clement Gakuba, Olivier Langlois, François Proust, Evelyne Emery, Thomas Gaberel
OBJECTIVES: Arteriovenous malformation (AVM) rupture could lead to intraventricular hemorrhage (IVH), a particularly severe form of intracranial bleeding. The epidemiology, presentation, management and outcomes of IVH related to AVM rupture have not been clearly addressed yet. The aim of the present study was to investigate the characteristics of IVH related to AVM rupture, with particular attention paid to functional outcomes and to the impact of intraventricular fibrinolysis (IVF). PATIENTS AND METHODS: Between 2011 and 2015, all patients suffering from IVH admitted in two tertiary neurosurgical centers were included in a prospective register...
December 4, 2017: Clinical Neurology and Neurosurgery
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