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https://www.readbyqxmd.com/read/28431043/male-gender-associated-with-post-treatment-seizure-risk-of-pediatric-arteriovenous-malformation-patients
#1
Wuyang Yang, Erick M Westbroek, Heather Anderson-Keightly, Justin M Caplan, Xiaoming Rong, Alice L Hung, Maria Braileanu, Joanna Y Wang, Geoffrey P Colby, Alexander L Coon, Rafael J Tamargo, Edward S Ahn, Judy Huang
BACKGROUND: Seizure risk has not been fully characterized in pediatric patients with arteriovenous malformations (AVMs). OBJECTIVE: To describe the progression and risk factors of post-treatment seizure in children with AVMs. METHODS: We retrospectively reviewed pediatric patients diagnosed with intracranial AVMs at our institution between 1990 and 2013. Clinical and angiographic variables were included in univariate and multivariate Cox proportional hazard models to explore risk factors associated with time-related seizure outcomes...
April 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28431024/radiosurgery-for-unruptured-brain-arteriovenous-malformations-an-international-multicenter-retrospective-cohort-study
#2
Dale Ding, Robert M Starke, Hideyuki Kano, John Y K Lee, David Mathieu, John Pierce, Paul Huang, Symeon Missios, Caleb Feliciano, Rafael Rodriguez-Mercado, Luis Almodovar, Inga S Grills, Danilo Silva, Mahmoud Abbassy, Douglas Kondziolka, Gene H Barnett, L Dade Lunsford, Jason P Sheehan
BACKGROUND: The role of intervention in the management of unruptured brain arteriovenous malformations (AVM) is controversial. OBJECTIVE: To analyze in a multicenter, retrospective cohort study, the outcomes following radiosurgery for unruptured AVMs and determine predictive factors. METHODS: We evaluated and pooled AVM radiosurgery data from 8 institutions participating in the International Gamma Knife Research Foundation. Patients with unruptured AVMs and ≥12 mo of follow-up were included in the study cohort...
April 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28426709/pdgfrb-is-a-direct-regulatory-target-of-tgf%C3%AE-signaling-in-atrioventricular-cushion-mesenchymal-cells
#3
Yin Peng, Shun Yan, Dongquan Chen, Xiangqin Cui, Kai Jiao
Cushion formation is the initial step for the development of valvuloseptal structures in mammalian hearts. TGFβ signaling plays critical roles in multiple steps of cushion morphogenesis. We used a newly developed conditional immortal atrioventricular cushion mesenchymal cell line, tsA58-AVM, to identify the TGFβ regulatory target genes through microarray analysis. Expression of ~1350 genes was significantly altered by TGFβ1 treatment. Subsequent bioinformatic analysis of TGFβ activated genes revealed that PDGF-BB signaling is the top hit as the potential upstream regulator...
2017: PloS One
https://www.readbyqxmd.com/read/28424275/outcomes-after-intracerebral-hemorrhage-from-arteriovenous-malformations
#4
Santosh B Murthy, Alexander E Merkler, Setareh Salehi Omran, Gino Gialdini, Aaron Gusdon, Benjamin Hartley, David Roh, Halinder S Mangat, Costantino Iadecola, Babak B Navi, Hooman Kamel
OBJECTIVE: To compare outcomes after intracerebral hemorrhage (ICH) from cerebral arteriovenous malformation (AVM) rupture and other causes of ICH. METHODS: We performed a retrospective population-based study using data from the Nationwide Inpatient Sample. We used standard diagnosis codes to identify ICH cases from 2002 to 2011. Our predictor variable was cerebral AVM. Our primary outcomes were inpatient mortality and home discharge. We used logistic regression to compare outcomes between patients with ICH with and without AVM while adjusting for demographics, comorbidities, and hospital characteristics...
April 19, 2017: Neurology
https://www.readbyqxmd.com/read/28424268/favorable-outcome-in-patients-with-intracranial-hemorrhage-due-to-ruptured-brain-avm
#5
EDITORIAL
Dennis R Buis
No abstract text is available yet for this article.
April 19, 2017: Neurology
https://www.readbyqxmd.com/read/28421824/thrombosis-of-the-draining-vein-causes-intracranial-haemorrhage-in-the-natural-history-of-brain-arteriovenous-malformation-case-report
#6
Raita Fukaya, Katsuhiro Mizutani, Masahito Fukuchi, Koji Fujii
Rupture of arteriovenous malformations (AVM) may be caused by venous outflow restriction, but there is no radiographic evidence of this. We report a case showing only a venous thrombus preceding intracranial haemorrhage from AVM. This is the first evidence that venous thrombus results in AVM rupture in its natural history.
April 19, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28415058/-a-case-of-arteriovenous-malformation-of-the-parotid-gland-associated-with-cowden-disease
#7
Kazuhiko Nishi, Satoshi Murai, Hisakazu Itami, Shinji Otsuka, Noboru Kusaka, Tsukasa Nishiura, Nobuhiko Kimura, Kotaro Ogihara
We report a rare case of arteriovenous malformation(AVM)of the parotid gland associated with Cowden disease successfully treated with preoperative embolization followed by surgical removal. A 39-year-old man with a history of Cowden disease presented with a pulsating and growing mass on his left lower jaw. Contrast-enhanced computed tomography(CT)and angiography revealed a high-flow AVM in the deep lobe of the left parotid gland. After intravascular embolization of the feeding arteries, surgery was performed using the NIM-response<sup>®</sup>3...
April 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28414573/phosphatidylserine-translocation-after-radiosurgery-in-an-animal-model-of-arteriovenous-malformation
#8
Newsha Raoufi Rad, Lucinda S McRobb, Zhenjun Zhao, Vivienne S Lee, Nirav J Patel, Anas Sarwar Qureshi, Michael Grace, Joshua J McHattan, Jude V Amal Raj, Hong Duong, Saleh R Kashba, Marcus A Stoodley
Phosphatidylserine (PS) is asymmetrically distributed across the plasma membrane, located predominantly on the inner leaflet in healthy cells. Translocation of PS to the outer leaflet makes it available as a target for biological therapies. We examined PS translocation after radiosurgery in an animal model of brain arteriovenous malformation (AVM). An arteriovenous fistula was created by end-to-side anastomosis of the left external jugular vein to the common carotid artery in 6-week-old, male Sprague Dawley rats...
April 17, 2017: Radiation Research
https://www.readbyqxmd.com/read/28413072/progressive-regression-of-intracranial-arteriovenous-malformations-after-onyx-embolization
#9
Damian Kocur, Nikodem Przybyłko, Mariusz Hofman, Tomasz Jamróz, Hanna Doleżych, Jan Baron, Stanisław Kwiek
Progressive regression of cerebral arteriovenous malformations (AVMs) is a rare phenomenon that may occur spontaneously or after previous surgical or endovascular incomplete obliteration. We present two cases of AVMs occluded partially with Onyx followed by the unexpected cure of the lesions with the angiographic evidences as well as multiannual follow-up.
April 4, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28411709/chronic-refractory-venous-ulcer-exacerbated-by-a-congenital-pelvic-arteriovenous-malformation-successfully-treated-by-transarterial-onyx-embolization
#10
Naiem Nassiri, Dustin T Crystal, Catherine Hoyt, Randy Shafritz
Congenital arteriovenous malformations (AVMs) are an important but often neglected cause of lower extremity venous hypertension. A case of a chronic refractory venous stasis ulcer of the lower extremity exacerbated by a pelvic AVM is presented. Healing of the ulcer was achieved at 2 months without recurrence at 1 year after superselective ethylene vinyl alcohol copolymer (Onyx 34; ev3, Covidien, Plymouth, Minn) embolization of the AVM nidus. Chronic venous arterialization should be considered in cases of refractory, nonhealing venous ulcers...
May 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28410479/analysis-of-sulfonamides-tilmicosin-and-avermectins-residues-in-typical-animal-matrices-with-multi-plug-filtration-cleanup-by-liquid-chromatography-tandem-mass-spectrometry-detection
#11
Yuhong Qin, Freedom Jatamunua, Jingru Zhang, Yanjie Li, Yongtao Han, Nan Zou, Jihao Shan, Yanbin Jiang, Canping Pan
The frequent use of various veterinary drugs could lead to residue bioaccumulation in animal tissues, which could cause dietary risks to human health. In order to quickly analyze the residues, a liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for detecting Sulfonamides, Tilmicosin and Avermectins (AVMs) residues in animal samples. For sample preparation, modified QuEChERS (quick, easy, cheap, effective, rugged and safe) and ultrasound-assisted extraction (UAE) methods were used...
April 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28408632/4d-dsa-for-dynamic-visualization-of-cerebral-vasculature-a-single-center-experience-in-26-cases
#12
S Lang, P Gölitz, T Struffert, J Rösch, K Rössler, M Kowarschik, C Strother, A Doerfler
BACKGROUND AND PURPOSE: 4D DSA allows acquisition of time-resolved 3D reconstructions of cerebral vessels by using C-arm conebeam CT systems. The aim of our study was to evaluate this new method by qualitative and quantitative means. MATERIALS AND METHODS: 2D and 4D DSA datasets were acquired in patients presenting with AVMs, dural arteriovenous fistulas, and cerebral aneurysms. 4D DSA was compared with 2D DSA in a consensus reading of qualitative and quantitative parameters of AVMs (eg, location, feeder, associated aneurysms, nidus size, drainage, Martin-Spetzler Score), dural arteriovenous fistulas (eg, fistulous point, main feeder, diameter of the main feeder, drainage), and cerebral aneurysms (location, neck configuration, aneurysmal size)...
April 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28401589/rhodoid-nevus-syndrome-why-is-this-name-preferable-to-%C3%A2-capillary-malformation-arteriovenous-malformation%C3%A2
#13
Rüdiger Panzer, Rudolf Happle, Regina Fölster-Holst
Until today, the term capillary malformation (CM) designates many quite different skin disorders.(1) One of them - called capillary malformation-arteriovenous malformation (CM-AVM)(2) - represents an autosomal dominant trait caused by mutations in RASA1.(3) We here describe the characteristic CMs of this trait in a child whithout any AVM, and provide arguments why the term CM-AVM should be replaced by "rhodoid nevus syndrome". This article is protected by copyright. All rights reserved.
April 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28400997/congenital-uterine-arteriovenous-malformation-presenting-as-postcoital-bleeding-a-rare-presentation-of-a-rare-clinical-condition
#14
Neha Agarwal, Seema Chopra, Neelam Aggarwal, Ujjwal Gorsi
Congenital uterine arteriovenous malformation (AVM) is an extremely rare condition with <100 cases documented in literature. We report multiparous women presenting to us with a history of postcoital bleed. Initial Doppler ultrasonography was consistent with features suggestive of AVM. Subsequently, computed tomography (CT) angiography confirmed the diagnosis. Embolization was chosen as the treatment because of the large extension of AVM and the risk of hemorrhage during hysterectomy. The patient was discharged in a stable condition with a plan of repeat embolization in the next setting...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28397378/basal-subarachnoid-hemorrhage-by-rupture-of-arteriovenous-malformation-at-the-cerebellopontine-angle
#15
Mio Takayama, Masayuki Kashiwagi, Kenji Hara, Aya Matsusue, Brian Waters, Natsuki Ikematsu, Shin-Ichi Kubo
A man in his late forties had lived as a recluse for more than ten years. He was found dead in his room. At autopsy, subarachnoid hemorrhage (SAH) was detected at the base of the brain, which weighed 1333 g. The cerebellar tonsil was swollen. The cerebral ventricle was enlarged and filled with blood. A hematoma was observed in the upper part of the left side of the cerebellar hemisphere. The location and size of SAH in this case indicated that the rupture of a cerebral aneurysm (CA) had occurred; however, CA was not detected...
April 10, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28389875/european-consensus-conference-on-unruptured-brain-avms-treatment-supported-by-eans-esmint-egks-and-sinch
#16
Marco Cenzato, Edoardo Boccardi, Ettore Beghi, Peter Vajkoczy, Istvan Szikora, Enrico Motti, Luca Regli, Andreas Raabe, Shalva Eliava, Andreas Gruber, Torstein R Meling, Mika Niemela, Alberto Pasqualin, Andrey Golanov, Bengt Karlsson, Andras Kemeny, Roman Liscak, Bodo Lippitz, Matthias Radatz, Alessandro La Camera, René Chapot, Civan Islak, Laurent Spelle, Alberto Debernardi, Elio Agostoni, Martina Revay, Michael K Morgan
In December of 2016, a Consensus Conference on unruptured AVM treatment, involving 24 members of the three European societies dealing with the treatment of cerebral AVMs (EANS, ESMINT, and EGKS) was held in Milan, Italy. The panel made the following statements and general recommendations: (1) Brain arteriovenous malformation (AVM) is a complex disease associated with potentially severe natural history; (2) The results of a randomized trial (ARUBA) cannot be applied equally for all unruptured brain arteriovenous malformation (uBAVM) and for all treatment modalities; (3) Considering the multiple treatment modalities available, patients with uBAVMs should be evaluated by an interdisciplinary neurovascular team consisting of neurosurgeons, neurointerventionalists, radiosurgeons, and neurologists experienced in the diagnosis and treatment of brain AVM; (4) Balancing the risk of hemorrhage and the associated restrictions of everyday activities related to untreated unruptured AVMs against the risk of treatment, there are sufficient indications to treat unruptured AVMs grade 1 and 2 (Spetzler-Martin); (5) There may be indications for treating patients with higher grades, based on a case-to-case consensus decision of the experienced team; (6) If treatment is indicated, the primary strategy should be defined by the multidisciplinary team prior to the beginning of the treatment and should aim at complete eradication of the uBAVM; (7) After having considered the pros and cons of a randomized trial vs...
April 7, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28377246/awake-surgery-for-brain-vascular-malformations-and-moyamoya-disease
#17
Rami James N Aoun, Mithun G Sattur, Chandan Krishna, Amen Gupta, Matthew E Welz, Allan D Nanney, Antoun H Koht, Matthew C Tate, Katherine H Noe, Joseph I Sirven, Barrett J Anderies, Patrick B Bolton, Terry L Trentman, Richard S Zimmerman, Kristin R Swanson, Bernard R Bendok
OBJECTIVE: While a significant amount of experience has accumulated for awake procedures for brain tumor, epilepsy and carotid surgery, its utility for intracranial neurovascular indications remains largely undefined. Awake surgery, for select neurovascular cases, offers the advantage of precise brain mapping and robust neurological monitoring during surgery for lesions in eloquent areas, avoidance of potential hemodynamic instability, and possible faster recovery. Additionally, it opens the window for perilesional epileptogenic tissue resection with potentially less risk for iatrogenic injury...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28373920/pulmonary-arteriovenous-malformation-causing-systemic-hypoxemia-in-early-infancy
#18
V Aggarwal, D M Khan, J F Rhodes
Pulmonary arteriovenous malformation (AVM) is not routinely appreciated during the standard echocardiogram to assess for structural abnormalities or pulmonary hypertension. The distal pulmonary AVM is suspected only if an injection of agitated saline is performed and late entry of particles is appreciated in the left heart structures. A large or complex pulmonary AVM can result in significant right-to-left shunting and consequential systemic hypoxemia in the presence or absence of pulmonary hypertension. For direct visualization of the pulmonary AVM, computerized tomography (CT) scan is the procedure of choice...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28362923/volume-staged-stereotactic-radiosurgery-for-intracranial-arteriovenous-malformations-outcomes-based-on-an-18-year-experience
#19
Bruce E Pollock, Michael J Link, Scott L Stafford, Giuseppe Lanzino, Yolanda I Garces, Robert L Foote
BACKGROUND: Radiation-based treatment options of large intracranial arteriovenous malformations (AVM) must balance the likelihood of obliteration with the risk of adverse radiation effects (ARE). OBJECTIVE: To analyze the efficacy and risks of volume-staged stereotactic radiosurgery (VS-SRS) for AVM. METHODS: Retrospective study of 34 AVM patients having VS-SRS between 1997 and 2012. A median of 2 stages (range, 2-4) was used to treat a median AVM volume of 22...
April 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28359509/autosomal-recessive-cardiomyopathy-presenting-as-acute-myocarditis
#20
Serkan Belkaya, Amy R Kontorovich, Minji Byun, Sonia Mulero-Navarro, Fanny Bajolle, Aurelie Cobat, Rebecca Josowitz, Yuval Itan, Raphaelle Quint, Lazaro Lorenzo, Soraya Boucherit, Cecile Stoven, Sylvie Di Filippo, Laurent Abel, Shen-Ying Zhang, Damien Bonnet, Bruce D Gelb, Jean-Laurent Casanova
BACKGROUND: Myocarditis is inflammation of the heart muscle that can follow various viral infections. Why children only rarely develop life-threatening acute viral myocarditis (AVM), given that the causal viral infections are common, is unknown. Genetic lesions might underlie such susceptibilities. Mouse genetic studies demonstrated that interferon (IFN)-α/β immunity defects increased susceptibility to virus-induced myocarditis. Moreover, variations in human TLR3, a potent inducer of IFNs, were proposed to underlie AVM...
April 4, 2017: Journal of the American College of Cardiology
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