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https://www.readbyqxmd.com/read/28930978/influenza-a-virus-studies-in-a-mouse-model-of-infection
#1
Laura Rodriguez, Aitor Nogales, Luis Martínez-Sobrido
Influenza viruses cause over 500,000 deaths worldwide(1) and are associated with an annual cost of 12 - 14 billion USD in the United States alone considering direct medical and hospitalization expenses and work absenteeism(2). Animal models are crucial in Influenza A virus (IAV) studies to evaluate viral pathogenesis, host-pathogen interactions, immune responses, and the efficacy of current and/or novel vaccine approaches as well as antivirals. Mice are an advantageous small animal model because their immune system is evolutionarily similar to that found in humans, they are available from commercial vendors as genetically identical subjects, there are multiple strains that can be exploited to evaluate the genetic basis of infections, and they are relatively inexpensive and easy to manipulate...
September 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930963/role-of-autophagy-and-its-molecular-mechanisms-in-mice-intestinal-tract-after-severe-burn
#2
Duan Y Zhang, Wei Qiu, PeiS Jin, Peng Wang, Yong Sun
BACKGROUND: Severe burn can lead to hypoxia/ischemia of intestinal mucosa. Autophagy is the process of intracellular degradation, which is essential for cell survival under stresses, such as hypoxia/ischemia and nutrient deprivation. The present study was designed to investigate whether there were changes in intestinal autophagy after severe burn in mice and further to explore the effect and molecular mechanisms of autophagy on intestinal injury. METHODS: This study includes three experiments...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930704/holding-ashley-x-bestowing-identity-through-caregiving-in-profound-intellectual-disability
#3
Lisa Freitag, Joan Liaschenko
The controversy over the so-called Ashley Treatment (AT), a series of medical procedures that inhibited both growth and sexual development in the body of a profoundly intellectually impaired girl, usually centers either on Ashley's rights, including a right to an intact, unaltered body, or on Ashley's parents' rights to make decisions for her. The claim made by her parents, that the procedure would improve their ability to care for her, is often dismissed as inappropriate or, at best, irrelevant. We argue, however, that caregiving is a central issue in the controversy, as Ashley's need for caregiving is a defining characteristic of her life...
2017: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/28930460/imaging-the-photodissociation-dynamics-of-nitrous-acid-hono-the-role-of-torsion
#4
Chandika Amarasinghe, Alexander Kamasah, Casey D Foley, James O F Thompson, Arthur G Suits
We present the findings of the first imaging study of trans-HONO and cis-HONO photodissociation through the band and of the 1A" -1A' transition. The NO photofragment was probed by (1+1) Resonance Enhanced Multiphoton Ionization (REMPI) and studied using the DC slice imaging technique with our Finite Slice reconstruction method (FinA). The NO state-specific translational energy distributions show some rotational structure corresponding to the internal state distribution in the OH co-fragment. All images showed a perpendicular angular distribution with a recoil anisotropy parameter around -0...
September 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28930219/qigong-in-cancer-care-theory-evidence-base-and-practice
#5
Penelope Klein
Background: The purpose of this discussion is to explore the theory, evidence base, and practice of Qigong for individuals with cancer. Questions addressed are: What is qigong? How does it work? What evidence exists supporting its practice in integrative oncology? What barriers to wide-spread programming access exist? Methods: Sources for this discussion include a review of scholarly texts, the Internet, PubMed, field observations, and expert opinion. Results: Qigong is a gentle, mind/body exercise integral within Chinese medicine...
January 12, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930172/rhein-induces-oxidative-stress-and-apoptosis-in-mouse-blastocysts-and-has-immunotoxic-effects-during-embryonic-development
#6
Chien-Hsun Huang, Wen-Hsiung Chan
Rhein, a glucoside chemical compound found in a traditional Chinese medicine derived from the roots of rhubarb, induces cell apoptosis and is considered to have high potential as an antitumor drug. Several previous studies showed that rhein can inhibit cell proliferation and trigger mitochondria-related or endoplasmic reticulum (ER) stress-dependent apoptotic processes. However, the side effects of rhein on pre- and post-implantation embryonic development remain unclear. Here, we show that rhein has cytotoxic effects on blastocyst-stage mouse embryos and induces oxidative stress and immunotoxicity in mouse fetuses...
September 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28929796/a-coordinated-control-strategy-for-insulin-and-glucagon-delivery-in-type-1-diabetes
#7
Pau Herrero, Jorge Bondia, Nick Oliver, Pantelis Georgiou
Type 1 diabetes is an autoimmune condition characterised by a pancreatic insulin secretion deficit, resulting in high blood glucose concentrations, which can lead to micro- and macrovascular complications. Type 1 diabetes also leads to impaired glucagon production by the pancreatic α-cells, which acts as a counter-regulatory hormone to insulin. A closed-loop system for automatic insulin and glucagon delivery, also referred to as an artificial pancreas, has the potential to reduce the self-management burden of type 1 diabetes and reduce the risk of hypo- and hyperglycemia...
September 20, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28929722/-self-perceived-health-status-among-immigrants-in-italy
#8
Alessio Petrelli, Anteo Di Napoli, Alessandra Rossi, Lidia Gargiulo, Concetta Mirisola, Gianfranco Costanzo
OBJECTIVES: to evaluate self-perceived health status of immigrants in Italy. DESIGN: cross-sectional study based on the representative national samples of the multipurpose surveys "Health conditions and use of health services" conducted in 2005 and 2013 by the Italian National Institute of Statistics (Istat). SETTING AND PARTICIPANTS: the study was conducted on the age group of 18-64: No. 80,661 in 2005, among which 3.2% were immigrants, and No...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28929511/dermatotoxicology-of-sulfur-mustard-historical-perspectives-from-world-war-i
#9
REVIEW
Austin Jiang, Howard Maibach
Sulfur mustard has been used as a chemical warfare agent for the past century. After its introduction by the Germans in World War I, investigators quickly began studying its impact on the human body including its deleterious effects on skin. This review focuses on two groups in particular who conducted experiments from 1917 to 1918: the United States Army at the American University Experiment Station Laboratories and Torald Sollmann at Western Reserve University. Through this work, these researchers proved far ahead of their time by anticipating dermatologic phenomena not described in the literature until later in the twentieth century...
September 19, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28929224/long-working-hours-directly-and-indirectly-via-short-sleep-duration-induce-headache-even-in-healthy-white-collar-men-cross-sectional-and-1-year-follow-up-analyses
#10
Teruo Nagaya, Minoru Hibino, Yasuaki Kondo
OBJECTIVE: Headache in employees may be linked with both overwork and sleep restriction induced by long working hours. Inter-relationships among working hours, sleep duration and headache were investigated. METHODS: Cross-sectional analyses for prevalent headache (n = 35,908) and 1-year follow-up analyses for incident headache (n = 19,788) were conducted in apparently healthy white-collar men aged 25-59 years. Headache (yes/no), working hours and sleep duration were based on self-administered questionnaire...
September 19, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28929024/effects-of-long-term-preservation-on-amphibian-body-conditions-implications-for-historical-morphological-research
#11
Guocheng Shu, Yuzhou Gong, Feng Xie, Nicholas C Wu, Cheng Li
Measurements of historical specimens are widely applied in studies of taxonomy, systematics, and ecology, but biologists often assume that the effects of preservative chemicals on the morphology of amphibian specimens are minimal in their analyses. We compared the body length and body mass of 182 samples of 13 live and preserved (up to 10 years) anuran species and found that the body length and body mass of preserved specimens significantly decreased by 6.1% and 24.8%, respectively, compared to those measurements of their live counterparts...
2017: PeerJ
https://www.readbyqxmd.com/read/28928393/high-quality-ecologically-sound-remediation-of-acidic-soil-using-bicarbonate-rich-swine-wastewater
#12
Cheng Qilu, Wu Xueling, Xu Ligen, Lin Hui, Zhao Yuhua, Zhou Qifa
The swine industry in China is experiencing a wastewater crisis. In this work, we found that swine wastewaters were particularly high in bicarbonate (1.52-9.25 g/L, mean = 5.68 g/L, n = 42). The high level of bicarbonate may add to the pollution load during discharge. We therefore suggest a new method for bicarbonate-rich wastewater remediation in acidic soil. In our laboratory irrigation experiments, wastewater irrigation efficiently increased the pH and decreased the exchangeable aluminum in the acidic soil...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927897/does-nutrition-play-a-role-in-the-prevention-and-management-of-sarcopenia
#13
REVIEW
S M Robinson, J Y Reginster, R Rizzoli, S C Shaw, J A Kanis, I Bautmans, H Bischoff-Ferrari, O Bruyère, M Cesari, B Dawson-Hughes, R A Fielding, J M Kaufman, F Landi, V Malafarina, Y Rolland, L J van Loon, B Vellas, M Visser, C Cooper
There is a growing body of evidence that links nutrition to muscle mass, strength and function in older adults, suggesting that it has an important role to play both in the prevention and management of sarcopenia. This review summarises the discussions of a working group [ESCEO working group meeting 8th September 2016] that met to review current evidence and to consider its implications for preventive and treatment strategies. The review points to the importance of 'healthier' dietary patterns that are adequate in quality in older age, to ensure sufficient intakes of protein, vitamin D, antioxidant nutrients and long-chain polyunsaturated fatty acids...
August 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28927864/anorexia-nervosa-and-childhood-sexual-abuse-treatment-outcomes-of-intensive-enhanced-cognitive-behavioural-therapy
#14
Simona Calugi, Cecilia Franchini, Silvia Pivari, Maddalena Conti, Marwan El Ghoch, Riccardo Dalle Grave
Sexual abuse has been widely studied as a risk factor in anorexia nervosa, but data on its influence on treatment outcomes are scarce. Hence, we compared short- and long-term outcomes of inpatient enhanced cognitive-behavioural therapy (CBT-E) in patients with anorexia nervosa who had and had not suffered sexual abuse. Eighty-one patients were recruited, and body mass index (BMI), Eating Disorder Examination, Brief Symptom Inventory, and Work and Social Adjustment Scale scores were recorded before and after treatment, and at 6- and 12-month follow-ups...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28927340/risk-factors-of-perioperative-morbimortality-after-laparoscopic-sleeve-gastrectomy-a-club-coelio-multicenter-study
#15
B Tulelli, P Loi, E van Vyve, H Johanet, G Fromont, A Dabrowski, A Piquart, T Delaunay, P Ledaguenel, B Navez, F Maisonnette, M Lepere, T Dugué, V Demoor, B Bokobza, Jp Staudt, P Hauters, P Malvaux, J Closset
OBJECTIVES: Postoperative complications after Laparoscopic sleeve gastrectomy (LSG) can dramatically compromise patient's outcome. The aim of this study is to analyze the per- and postoperative short-term outcomes after LSG and to assess predictive risk factors of complications. METHODS: The study group consisted of 790 patients (610 women and 180 men) who underwent LSG In 2014. All interventions were performed by 18 experienced surgeons members of the Club Coelio...
September 19, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28926786/polybrominated-diphenyl-ethers-and-indicator-polychlorinated-biphenyls-in-human-milk-from-china-under-the-stockholm-convention
#16
Lei Zhang, Shuaixing Yin, Yunfeng Zhao, Zhixiong Shi, Jingguang Li, Yongning Wu
Seven congeners of polybrominated diphenyl ethers (PBDEs) (BDE-28, BDE-47, BDE-99, BDE-100, BDE-153,BDE-154 and BDE-183) and six indicator polychlorinated biphenyls (PCBs) (PCB-28, PCB-52, PCB-101, PCB-138, PCB-153 and PCB-180) were measured in 32 regional pooled human milk samples originating from 1760 volunteering primiparous mothers to evaluate the current human body burden of general population and the temporal trend in China. Individual human milk samples were collected following a WHO-designed procedure...
September 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28926780/validation-of-a-standard-forensic-anthropology-examination-protocol-by-measurement-of-applicability-and-reliability-on-exhumed-and-archive-samples-of-known-biological-attribution
#17
Raffaela Arrabaça Francisco, Martin Paul Evison, Moacyr Lobo da Costa Junior, Teresa Cristina Pantozzi Silveira, José Marcelo Secchieri, Marco Aurelio Guimarães
Forensic anthropology makes an important contribution to human identification and assessment of the causes and mechanisms of death and body disposal in criminal and civil investigations, including those related to atrocity, disaster and trafficking victim identification. The methods used are comparative, relying on assignment of questioned material to categories observed in standard reference material of known attribution. Reference collections typically originate in Europe and North America, and are not necessarily representative of contemporary global populations...
September 7, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28926615/predicting-the-reward-value-of-faces-and-bodies-from-social-perception
#18
Danielle Morrison, Hongyi Wang, Amanda C Hahn, Benedict C Jones, Lisa M DeBruine
Social judgments of faces are thought to be underpinned by two perceptual components: valence and dominance. Recent work using a standard key-press task to assess reward value found that these valence and dominance components were both positively related to the reward value of faces. Although bodies play an important role in human social interaction, the perceptual dimensions that underpin social judgments of bodies and their relationship to the reward value of bodies are not yet known. The current study investigated these issues...
2017: PloS One
https://www.readbyqxmd.com/read/28926155/idna-screening-disease-vectors-as-vertebrate-samplers
#19
Arthur Kocher, Benoit De Thoisy, François Catzeflis, Sophie Valiere, Anne-Laure Bañuls, Jérôme Murienne
In the current context of global change and human-induced biodiversity decline, there is an urgent need for developing sampling approaches able to accurately describe the state of biodiversity. Traditional surveys of vertebrate fauna involve time-consuming and skill-demanding field methods. Recently, the use of DNA derived from invertebrate parasites (leeches and blowflies) was suggested as a new tool for vertebrate diversity assessment. Blood meal analyses of arthropod disease vectors have long been performed to describe their feeding behaviour, for epidemiological purposes...
September 19, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28925727/the-effect-of-person-order-on-egress-time-a-simulation-model-of-evacuation-from-a-neolithic-visitor-attraction
#20
Arthur Stewart, Eyad Elyan, John Isaacs, Leah McEwen, Lyn Wilson
OBJECTIVE: The aim of this study was to model the egress of visitors from a Neolithic visitor attraction. BACKGROUND: Tourism attracts increasing numbers of elderly and mobility-impaired visitors to our built-environment heritage sites. Some such sites have very limited and awkward access, were not designed for mass visitation, and may not be modifiable to facilitate disabled access. As a result, emergency evacuation planning must take cognizance of robust information, and in this study we aimed to establish the effect of visitor position on egress...
September 1, 2017: Human Factors
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