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https://www.readbyqxmd.com/read/28432297/high-probability-of-comorbidities-in-bronchial-asthma-in-germany
#1
S Heck, S Al-Shobash, D Rapp, D D Le, A Omlor, A Bekhit, M Flaig, B Al-Kadah, W Herian, R Bals, S Wagenpfeil, Q T Dinh
Clinical experience has shown that allergic and non-allergic respiratory, metabolic, mental, and cardiovascular disorders sometimes coexist with bronchial asthma. However, no study has been carried out that calculates the chance of manifestation of these disorders with bronchial asthma in Saarland and Rhineland-Palatinate, Germany. Using ICD10 diagnoses from health care institutions, the present study systematically analyzed the co-prevalence and odds ratios of comorbidities in the asthma population in Germany...
April 21, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28431569/co-colonisation-with-aspergillus-fumigatus-and-pseudomonas-aeruginosa-is-associated-with-poorer-health-in-cystic-fibrosis-patients-an-irish-registry-analysis
#2
Emma Reece, Ricardo Segurado, Abaigeal Jackson, Siobhán McClean, Julie Renwick, Peter Greally
BACKGROUND: Pulmonary infection is the main cause of death in cystic fibrosis (CF). Aspergillus fumigatus (AF) and Pseudomonas aeruginosa (PA) are the most prevalent fungal and bacterial pathogens isolated from the CF airway, respectively. Our aim was to determine the effect of different colonisation profiles of AF and PA on the clinical status of patients with CF. METHODS: A retrospective analysis of data from the Cystic Fibrosis Registry of Ireland from 2013 was performed to determine the effect of intermittent and persistent colonisation with AF or PA or co-colonisation with both microorganisms on clinical outcome measures in patients with CF...
April 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28431001/invasive-aspergillosis-in-patients-with-underlying-liver-cirrhosis-a-prospective-cohort-study
#3
Juergen Prattes, Martin Hoenigl, Robert Krause, Walter Buzina, Thomas Valentin, Frederike Reischies, Christoph Koidl, Ines Zollner-Schwetz
The aim of this study was to determine the prevalence of invasive aspergillosis (IA) in patients with liver cirrhosis and the performance of serum galactomannan (GM) screening. Patients with decompensated liver cirrhosis and patients with compensated liver cirrhosis presenting with fever and/or respiratory symptoms were prospectively enrolled. All patients were screened by serum GM twice weekly irrespective of clinical signs and symptoms. Positive serum GM triggered work-up consisting of chest computed tomography and in case of pathological findings bronchoscopy...
April 20, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28427940/characterization-of-the-rax1-gene-encoding-a-putative-regulator-of-g-protein-signaling-in-aspergillus-fumigatus
#4
Olumuyiwa Ayokunle Igbalajobi, Jae-Hyuk Yu, Kwang-Soo Shin
The filamentous fungus Aspergillus fumigatus is the major cause of life threatening invasive aspergillosis, and its small hydrophobic asexual spores (conidia) are the major infection agent. To better understand biology of A. fumigatus, we have characterized the rax1 gene encoding a putative regulator of G protein signaling (RGS). The deletion (Δ) of rax1 results in restricted colony growth and highly reduced number of conidia in A. fumigatus. Transcript levels of the three central activators of asexual development abaA, brlA, and wetA are significantly reduced in the Δrax1 mutant...
April 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28423094/complications-of-chronic-necrotizing-pulmonary-aspergillosis-review-of-published-case-reports
#5
Aleksandra Barac, Tatjana Adzic Vukicevic, Aleksandra Dudvarski Ilic, Salvatore Rubino, Vladimir Zugic, Goran Stevanovic
Chronic necrotizing pulmonary aspergillosis (CNPA), a form of chronic pulmonary aspergillosis (CPA), affects immunocompetent or mildly immunocompromised persons with underlying pulmonary disease. These conditions are associated with high morbidity and mortality and often require long-term antifungal treatment. The long-term prognosis for patients with CNPA and the potential complications of CNPA have not been well documented. The aim of this study was to review published papers that report cases of CNPA complications and to highlight risk factors for development of CNPA...
April 13, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28422065/detection-of-1-3-%C3%AE-d-glucan-for-the-diagnosis-of-invasive-fungal-infection-in-liver-transplant-recipients
#6
Eric Levesque, Fadi Rizk, Zaid Noorah, Nawel Aït-Ammar, Catherine Cordonnier-Jourdin, Sarra El Anbassi, Christine Bonnal, Daniel Azoulay, Jean-Claude Merle, Françoise Botterel
Invasive fungal infections (IFI) are complications after liver transplantation involving high morbidity and mortality. (1,3)-β-d-glucan (BG) is a biomarker for IFI, but its utility remains uncertain. This study was designed to evaluate the impact of BG following their diagnosis. Between January 2013 and May 2016, 271 liver transplants were performed in our institution. Serum samples were tested for BG (Fungitell(®), Associates Cape Code Inc., Falmouth, MA, USA) at least weekly between liver transplantation and the discharge of patients...
April 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28416540/in-vivo-efficacy-of-liposomal-amphotericin-b-against-wild-type-and-azole-resistant-aspergillus-fumigatus-isolates-in-two-different-immunosuppressed-models-of-invasive-aspergillosis
#7
Seyedmojtaba Seyedmousavi, Johan W Mouton, Willem J G Melchers, Paul E Verweij
Using an immunocompetent murine model of invasive aspergillosis (IA), we previously reported (AAC, 2013, 57, 4, 1866-1871) that the efficacy of liposomal amphotericin B (L-AmB) is not hampered by the presence of azole resistance mutations in Aspergillus fumigatus We here investigated the role of immune suppression, i.e. neutropenic and steroid-treated, on L-AmB efficacy in mice infected with a wild type (WT) and azole-resistant Aspergillus fumigatus harboring TR34/L98H mutation in cyp-51A gene.Survival of treated animals at day 14 in both immunosuppressed models was significantly better than that of non-treated controls...
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28412383/a-prospective-international-aspergillus-terreus-survey-an-efisg-isham-and-ecmm-joint-study
#8
Brigitte Risslegger, Tamara Zoran, Michaela Lackner, Maria Aigner, Ferran Sánchez-Reus, Antonio Rezusta, Anuradha Chowdhary, Saad Jaber Taj-Aldeen, Maiken C Arendrup, Salvatore Oliveri, Dimitrios P Kontoyiannis, Ana Alastruey-Izquierdo, Katrien Lagrou, Giuliana Lo Cascio, Jacques F Meis, Walter Buzina, Claudio Farina, Miranda Drogari-Apiranthitou, Anna Grancini, Anna Maria Tortorano, Birgit Willinger, Axel Hamprecht, Elizabeth Johnson, Lena Klingspor, Valentina Arsic-Arsenijevic, Oliver A Cornely, Joseph Meletiadis, Wolfgang Prammer, Vivian Tullio, Jörg-Janne Vehreschild, Laura Trovato, Russell E Lewis, Esther Segal, Peter-Michael Rath, Petr Hamal, Manuel Rodriguez-Iglesias, Emmanuel Roilides, Sevtap Arikan-Akdagli, Arunaloke Chakrabarti, Arnaldo L Colombo, Mariana S Fernández, M Teresa Martin-Gomez, Hamid Badali, Georgios Petrikkos, Nikolai Klimko, Sebastian M Heimann, Jos Houbraken, Omrum Uzun, Michael Edlinger, Sonia de la Fuente, Cornelia Lass-Flörl
OBJECTIVES: A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B (AMB) susceptibility of Aspergillus terreus species complex infections. METHODS: Three hundred seventy cases from 21 countries were evaluated. RESULTS: The overall prevalence of A. terreus species complex among patients investigated and with mold positive cultures was 5.2% (370/7116). AMB MICs were ranging from 0...
April 13, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28409094/successful-treatment-of-azole-resistant-invasive-aspergillosis-in-a-bottlenose-dolphin-with-high-dose-posaconazole
#9
Paulien E Bunskoek, Seyedmojtaba Seyedmousavi, Steven J M Gans, Peter B J van Vierzen, Willem J G Melchers, Cornelis E van Elk, Johan W Mouton, Paul E Verweij
Invasive aspergillosis due to azole-resistant Aspergillus fumigatus is difficult to manage. We describe a case of azole-resistant invasive aspergillosis in a female bottlenose dolphin, who failed to respond to voriconazole and posaconazole therapy. As intravenous therapy was precluded, high dose posaconazole was initiated aimed at achieving trough levels exceeding 3 mg/l. Posaconazole serum levels of 3-9.5 mg/l were achieved without significant side-effects. Follow-up bronchoscopy and computed tomography showed complete resolution of the lesions...
June 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28397466/absolute-eosinophil-count-was-significantly-associated-with-serum-1-3-%C3%AE-d-glucan-in-patients-with-invasive-fungal-infections
#10
Pengfei Zhu, Jun Lv, Yongkui Kong, Hui Xu, Liang Ming
BACKGROUND: Measurement of serum (1,3)-β-D-glucan has emerged as an important diagnostic strategy for invasive fungal infections (IFI). Previous studies suggested that the eosinophil count would be related with the value of serum (1,3)-β-D-glucan. METHODS: 572 blood samples obtained from 126 patients at the First Affiliated Hospital of Zhengzhou University were analyzed. The unsuitable samples were excluded according to the patient selection. RESULTS: In our study, we found that in the 572 cumulative results, the absolute eosinophil count was significantly associated with the value of (1,3)-β-D-glucan (r = 0...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28395406/-expression-and-differential-diagnostic-value-of-serum-microrna-for-invasive-pulmonary-aspergillosis
#11
Z N Wen, Z G Ling, Y Huang, X Li
Objective: To explore the expression and the clinical diagnostic value of serum miR-21 for invasive pulmonary aspergillosis (IPA). Methods: Outpatients and inpatients from the Fourth Affiliated Hospital of Guangxi Medical University were included in the study during June 2014 to September 2015. The IPA group had 40 patients, male 22, female 18, aged 55-68 years (mean 60 ), while the control groups included 50 patients with pulmonary tuberculosis [male 23, female 27, aged 50-62 years (mean 55 )], 50 patients with lung cancer [male 30, female 20, aged 55-70 years (mean 62)], and 50 healthy controls [male 25, female 25, aged 50-67 years (mean 60) ]...
April 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28394553/drug-induced-oral-ulcerations-case-report
#12
Vanja Vučičević Boras, Snježana Židovec-Lepej, Branka Marinović, Sven Seiwerth, Ivana Škrinjar, Dražen Pulanić, Danica Vidović Juras
A 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency, with complete afunction of the right kidney, asthma, hypertension, gastritis and prostate hyperplasia. Differential diagnosis of oral ulcerations included drug induced oral ulcerations, paraneoplastic pemphigus, viral ulcerations (cytomegalovirus, herpes simplex viruses), fungal ulcerations (candidiasis, aspergillosis, histoplasmosis, cryptococcosis) and bacterial ulcerations, as well as neutropenic ulcers...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28392660/primary-cutaneous-aspergillosis-after-tattoo-removal-using-a-1-064-nm-q-switched-nd-yag-laser-in-an-immunocompetent-patient
#13
Hyeong-Rae Kim, Jung-Min Shin, Jin-Hyup Lee, Hae-Eul Lee, Myung Im, Young Lee, Chang-Deok Kim, Young-Joon Seo, Jeung-Hoon Lee
No abstract text is available yet for this article.
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28389392/il-10-overexpression-predisposes-to-invasive-aspergillosis-by-suppressing-antifungal-immunity
#14
Cristina Cunha, Samuel M Gonçalves, Cláudio Duarte-Oliveira, Luís Leite, Katrien Lagrou, António Marques, Carmen B Lupiañez, Inês Mesquita, Joana Gaifem, Ana Margarida Barbosa, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Cornelia Lass-Flörl, Jürgen Löffler, Manuel Jurado, Margarida Saraiva, Oliver Kurzai, Fernando Rodrigues, António G Castro, Ricardo Silvestre, Juan Sainz, Johan A Maertens, Egídio Torrado, Ilse D Jacobsen, João F Lacerda, António Campos, Agostinho Carvalho
We show that the genetically-determined overexpression of IL-10 is a risk factor for invasive aspergillosis after stem-cell transplantation. Our results identify an IL-10-mediated mechanism that regulates the balance between anti- and proinflammatory antifungal immunity.
April 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28387526/influenza-associated-aspergillosis-in-critically-ill-patients
#15
Frank L van de Veerdonk, Eva Kolwijck, Pieter P A Lestrade, Caspar J Hodiamont, Bart J A Rijnders, Judith van Paassen, Pieter-Jan Haas, Claudy Oliveira Dos Santos, Greetje A Kampinga, Dennis C J J Bergmans, Karin van Dijk, Anton F J de Haan, Jaap van Dissel, Hans G van der Hoeven, Paul E Verweij
No abstract text is available yet for this article.
April 7, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28387203/extensive-mediastinal-aspergillosis-presenting-with-dyspnoea-and-cardiac-tamponade-symptoms
#16
Syed F Mustafa, Hamza Ar Khan, Saulat H Fatimi
No abstract text is available yet for this article.
April 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28384860/fungal-opportunistic-pneumonias-in-hiv-aids-patients-an-indian-tertiary-care-experience
#17
Ravinder Kaur, Bhanu Mehra, Megh Singh Dhakad, Ritu Goyal, Preena Bhalla, Richa Dewan
INTRODUCTION: Opportunistic pneumonias are a major cause of mortality and morbidity in Human Immunodeficiency Virus (HIV) reactive patients. Despite the significant role that fungi play in causation of this opportunistic mycoses, very few Indian studies have attempted to investigate the burden and aetiological spectrum of HIV/AIDS-associated fungal pneumonias. AIM: To document the prevalence of fungal aetiology in HIV/AIDS-related opportunistic pneumonias in an Indian setting; and to elucidate the various fungal opportunists responsible for the same...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28384600/a-prospective-study-of-fungal-biomarkers-to-improve-management-of-invasive-fungal-diseases-in-a-mixed-specialty-critical-care-unit
#18
Alida Fe Talento, Katie Dunne, Eimear Ann Joyce, Michael Palmer, Elizabeth Johnson, P Lewis White, Jan Springer, Juergen Loeffler, Thomas Ryan, Daniel Collins, Thomas R Rogers
PURPOSE: The diagnosis of invasive fungal diseases (IFD) in critical care patients (CrCP) is difficult. The study investigated the performance of a set of biomarkers for diagnosis of IFD in a mixed specialty critical care unit (CrCU). METHODS: A prospective observational study in patients receiving critical care for ≥7days was performed. Serum samples were tested for the presence of: (1-3) - β-d-glucan (BDG), galactomannan (GM), and Aspergillus fumigatus DNA...
March 30, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28380215/recombinant-60-kda-heat-shock-protein-from-paracoccidioides-brasiliensis-is-it-a-good-antigen-for-serological-diagnosis-of-paracoccidioidomycosis
#19
G Peron, F F Fernandes, T N Landgraf, R Martinez, A Panunto-Castelo
Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. lutzii suggests that preparation with only one antigen is not recommended. Heat shock proteins are feasible alternatives as a second antigen because they are often highly immunogenic...
April 3, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28379569/one-health-pathogens-in-the-aspergillus-viridinutans-complex
#20
Jessica J Talbot, Vanessa R Barrs
Cryptic species in Aspergillus section Fumigati are increasingly recognised as pathogens in humans and animals. The A. viridinutans complex (AVC) has recently expanded to comprise 10 species, of which six are known to be pathogenic, including A. udagawae, A. felis, A. pseudofelis, A. parafelis, A. pseudoviridinutans, and A. wyomingensis. They cause locally invasive and disseminated invasive disease syndromes, including chronic pulmonary aspergillosis and invasive aspergillosis in humans, invasive fungal rhinosinusitis in cats, and disseminated invasive aspergillosis in dogs...
March 31, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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