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https://www.readbyqxmd.com/read/28426287/pregnancy-and-the-acceptability-of-computer-based-versus-traditional-mental-health-treatments
#1
Liisa Hantsoo, Jessica Podcasy, Mary Sammel, Cynthia Neill Epperson, Deborah R Kim
BACKGROUND: Recent recommendations urge increased depression screening in pregnant and postpartum women, potentially increasing demand for treatment. Computer-based psychotherapy treatments may address some of perinatal women's unique mental health treatment needs and barriers. MATERIALS AND METHODS: We conducted a quantitative survey of pregnant women (≥12 weeks of gestation) on preferences regarding computer-based therapies compared with traditional therapies (psychotherapy and medication)...
April 20, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28416479/suppression-of-integrin-%C3%AE-3%C3%AE-1-by-%C3%AE-9%C3%AE-1-in-the-epidermis-controls-the-paracrine-resolution-of-wound-angiogenesis
#2
Whitney M Longmate, Scott P Lyons, Sridar V Chittur, Kevin M Pumiglia, Livingston Van De Water, C Michael DiPersio
Development of wound therapies is hindered by poor understanding of combinatorial integrin function in the epidermis. In this study, we generated mice with epidermis-specific deletion of α3β1, α9β1, or both integrins as well as keratinocyte lines expressing these integrin combinations. Consistent with proangiogenic roles for α3β1, α3-null keratinocytes showed reduced paracrine stimulation of endothelial cell migration and survival, and wounds of epidermis-specific α3 knockout mice displayed impaired angiogenesis...
April 17, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28414013/the-efficacy-of-primary-care-chaplaincy-compared-with-antidepressants-a-retrospective-study-comparing-chaplaincy-with-antidepressants
#3
Gordon Macdonald
Aim To determine the effectiveness of primary care chaplaincy (PCC) when used as the sole intervention, with outcomes being compared directly with those of antidepressants. This was to be carried out in a homogenous study population reflective of certain demographics in the United Kingdom. BACKGROUND: Increasing numbers of patients are living with long-term conditions and 'modern maladies' and are experiencing loss of well-being and depression. There is an increasing move to utilise non-pharmacological interventions such as 'talking therapies' within this context...
April 17, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28408544/cost-and-outcome-of-behavioural-activation-versus-cognitive-behavioural-therapy-for-depression-cobra-a-qualitative-process-evaluation
#4
Katie Finning, David A Richards, Lucy Moore, David Ekers, Dean McMillan, Paul A Farrand, Heather A O'Mahen, Edward R Watkins, Kim A Wright, Emily Fletcher, Shelley Rhodes, Rebecca Woodhouse, Faye Wray
OBJECTIVE: To explore participant views on acceptability, mechanisms of change and impact of behavioural activation (BA) delivered by junior mental health workers (MHWs) versus cognitive behavioural therapy (CBT) delivered by professional psychotherapists. DESIGN: Semistructured qualitative interviews analysed using a framework approach. PARTICIPANTS: 36 participants with major depressive disorder purposively sampled from a randomised controlled trial of BA versus CBT (the COBRA trial)...
April 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28403464/supporting-aboriginal-women-to-quit-smoking-antenatal-and-postnatal-care-providers-confidence-attitudes-and-practices
#5
Flora Tzelepis, Justine Daly, Sarah Dowe, Alex Bourke, Karen Gillham, Megan Freund
Introduction: Tobacco use during pregnancy is substantially higher among Aboriginal women compared to non-Aboriginal women in Australia. However, no studies have investigated the amount or type of smoking cessation care that staff from Aboriginal antenatal and postnatal services provide to clients who smoke or staff confidence to do so. This study examined Aboriginal antenatal and postnatal staff confidence, perceived role and delivery of smoking cessation care to Aboriginal women and characteristics associated with provision of such care...
May 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28400917/coronary-stenting-a-matter-of-revascularization
#6
EDITORIAL
Aldo Bonaventura, Fabrizio Montecucco, Luca Liberale
In the last few decades, the recommended treatment for coronary artery disease has been dramatically improved by percutaneous coronary intervention (PCI) and the use of balloon catheters, bare metal stents (BMSs), and drug-eluting stents (DESs). Catheter balloons were burdened by acute vessel occlusion or target-lesion re-stenosis. BMSs greatly reduced those problems holding up the vessel structure, but showed high rates of in-stent re-stenosis, which is characterized by neo-intimal hyperplasia and vessel remodeling leading to a re-narrowing of the vessel diameter...
March 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28389420/the-reviews-are-in-a-qualitative-content-analysis-of-consumer-perspectives-on-apps-for-bipolar-disorder
#7
Jennifer Nicholas, Andrea S Fogarty, Katherine Boydell, Helen Christensen
BACKGROUND: The delivery of mobile health (mHealth) services is acceptable to mental health consumers. However, despite the benefits of accessibility, cost-effectiveness, anonymity, and ability to tailor content to individual needs, consumer engagement remains a hurdle for uptake and continued use. This may be unsurprising as few studies have examined app content from the consumer perspective or assessed consumer preferences for the content of apps for mental health management. An opportunity to examine consumer perspectives exists in using naturally generated data that is publically available in the Google Play and Apple app stores...
April 7, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28388533/brca1-haploinsufficiency-cell-autonomously-activates-rankl-expression-and-generates-denosumab-responsive-breast-cancer-initiating-cells
#8
Elisabet Cuyàs, Bruna Corominas-Faja, María Muñoz-San Martín, Begoña Martin-Castillo, Ruth Lupu, Joan Brunet, Joaquim Bosch-Barrera, Javier A Menendez
Denosumab, a monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), might be a novel preventative therapy for BRCA1-mutation carriers at high risk of developing breast cancer. Beyond its well-recognized bone-targeted activity impeding osteoclastogenesis, denosumab has been proposed to interfere with the cross-talk between RANKL-producing sensor cells and cancer-initiating RANK+ responder cells that reside within premalignant tissues of BRCA1-mutation carriers. We herein tested the alternative but not mutually exclusive hypothesis that BRCA1 deficiency might cell-autonomously activate RANKL expression to generate cellular states with cancer stem cell (CSC)-like properties...
March 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28386299/highlights-from-the-ecancer-future-horizons-in-lung-cancer-conference-1-2-september-2016-focusing-on-the-future-of-treatment-for-nsclc-and-sclc
#9
Kayleigh Bassiri, Linda Cairns, Gordon McVie, Michael Seckl
The 'Future Horizons in Lung Cancer' meeting was designed to bring leading scientists together alongside clinicians to discuss the most recent advances in lung cancer pathophysiology and treatment. The aim was to take those attending the event on a journey through decades of lung cancer research and understanding, with topics spanning from screening and surgical care to "omics" approaches for drug target and biomarker discovery. There were also several talks describing the role of radiotherapy in lung cancer and advancements in imaging techniques, aiding surgeons in their attempts to resect early lesions...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28373060/cross-talk-between-the-ck2-and-akt-signaling-pathways-in-cancer
#10
REVIEW
Maria Ruzzene, Jessika Bertacchini, Alex Toker, Sandra Marmiroli
CK2 and AKT display a high degree of cross-regulation of their respective functions, both directly, through physical interaction and phosphorylation, and indirectly, through an intense cross-talk of key downstream effectors, ultimately leading to sustained AKT activation. Being CK2 and AKT attractive targets for therapeutic intervention, here we would like to emphasize how AKT and CK2 might influence cell fate through their complex isoform-specific and contextual-dependent cross-talk, to the extent that such functional interplay should be considered when devising therapies that target one or both these key signaling kinases...
March 28, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28369805/exosomes-carrying-immunoinhibitory-proteins-and-their-role-in-cancer
#11
REVIEW
Theresa L Whiteside
Recent emergence of exosomes as information carriers between cells has introduced us to a new previously unknown biological communication system. Multi-directional cross-talk mediated by exosomes carrying proteins, lipids, and nucleic acids between normal cells, cells harboring a pathogen or cancer and immune cells has been instrumental in determining outcomes of physiological as well as pathological conditions. Exosomes play a key role in the broad spectrum of human diseases. In cancer, tumor-derived exosomes carry multiple immunoinhibitory signals, disable anti-tumor immune effector cells and promote tumor escape from immune control...
April 2, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28368335/recent-advances-in-targeting-the-egfr-signaling-pathway-for-the-treatment-of-metastatic-colorectal-cancer
#12
REVIEW
Yuji Miyamoto, Koichi Suyama, Hideo Baba
Outcomes for metastatic colorectal cancer (mCRC) patients have been improved by treatment with anti-epidermal growth factor receptor (anti-EGFR) antibodies, particularly when combined with predictive biomarkers to select patients lacking RAS mutations. New technologies such as liquid biopsy and next-generation sequencing have revealed that potential mechanisms of resistance to anti-EGFR therapies act through acquired mutations of KRAS and the EGFR ectodomain. Mutations in cross-talking molecular effectors that participate in downstream EGFR signaling are also negative predictors for anti-EGFR therapy...
April 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28358030/allosteric-cross-talk-in-chromatin-can-mediate-drug-drug-synergy
#13
Zenita Adhireksan, Giulia Palermo, Tina Riedel, Zhujun Ma, Reyhan Muhammad, Ursula Rothlisberger, Paul J Dyson, Curt A Davey
Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of one drug alters the activity of the second. We found two unrelated drugs, RAPTA-T and auranofin, that yield a synergistic activity in killing cancer cells, which coincides with a substantially greater number of chromatin adducts formed by one of the compounds when adducts from the other agent are also present...
March 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28353036/resistance-to-hormonal-therapy-in-prostate-cancer
#14
Alfredo Berruti, Alberto Dalla Volta
Several therapeutic strategies are actually available in the management of prostate cancer: Targeting the androgen receptor (AR) is the goal both for initial androgen deprivation therapy (ADT) and second-generation androgen ablative agents (abiraterone and enzalutamide). Chemotherapy with taxanes, administered upon progression or as first line approach in association with ADT, is another therapeutic option. Unfortunately, none of these therapies is curative and patients are destined to develop a resistant phenotype...
March 29, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28344166/micrornas-as-players-and-signals-in-the-metastatic-cascade-implications-for-the-development-of-novel-anti-metastatic-therapies
#15
REVIEW
Paolo Gandellini, Valentina Doldi, Nadia Zaffaroni
microRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. Increasing evidence emerging from human tumor preclinical models clearly indicates that specific miRNAs, collectively termed "metastamirs," play a functional role in different steps of the metastatic cascade, by exerting either pro- or anti-metastatic functions, and behave as signaling mediators to enable tumor cell to colonize a specific organ. miRNAs also actively participate in the proficient interaction of cancer cells with tumor microenvironment, either at the primary or at the metastatic site...
March 23, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28341889/complement-regulation-and-kidney-diseases-recent-knowledge-of-the-double-edged-roles-of-complement-activation-in-nephrology
#16
REVIEW
Masashi Mizuno, Yasuhiro Suzuki, Yasuhiko Ito
The complement activation system plays important roles to maintain homeostasis in the host and to fight foreign invaders to protect the host. Therefore, the complement system is considered a core part of innate immunity which also cross-talks to acquired immunity. In the history of nephrology, the complement system is familiar to us, because complement protein or fragment deposition, including C3, C4, C1q, and/or C4d, is routinely estimated by immunohistochemistry to diagnose renal pathologies. The relationships between pathological mechanisms and complement activation have been investigated for renal diseases such as post-infectious glomerulonephritis, lupus nephritis, and primary membranoproliferative glomerulonephritis, which are usually accompanied by hypocomplementemia...
March 24, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28329366/ambulatory-voice-biofeedback-relative-frequency-and-summary-feedback-effects-on-performance-and-retention-of-reduced-vocal-intensity-in-the-daily-lives-of-participants-with-normal-voices
#17
Jarrad H Van Stan, Daryush D Mehta, Dagmar Sternad, Robert Petit, Robert E Hillman
Purpose: Ambulatory voice biofeedback has the potential to significantly improve voice therapy effectiveness by targeting carryover of desired behaviors outside the therapy session (i.e., retention). This study applies motor learning concepts (reduced frequency and delayed, summary feedback) that demonstrate increased retention to ambulatory voice monitoring for training nurses to talk softer during work hours. Method: Forty-eight nurses with normal voices wore the Voice Health Monitor (Mehta, Zañartu, Feng, Cheyne, & Hillman, 2012) for 6 days: 3 baseline days, 1 biofeedback day, 1 short-term retention day, and 1 long-term retention day...
March 21, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28325757/loss-of-cd73-prevents-accumulation-of-alternatively-activated-macrophages-and-the-formation-of-prefibrotic-macrophage-clusters-in-irradiated-lungs
#18
Simone de Leve, Florian Wirsdörfer, Federica Cappuccini, Alexandra Schütze, Alina V Meyer, Katharina Röck, Linda F Thompson, Jens W Fischer, Martin Stuschke, Verena Jendrossek
While radiotherapy is a mainstay for cancer therapy, pneumonitis and fibrosis constitute dose-limiting side effects of thorax and whole body irradiation. So far, the contribution of immune cells to disease progression is largely unknown. Here we studied the role of ecto-5'-nucelotidase (CD73)/adenosine-induced changes in the myeloid compartment in radiation-induced lung fibrosis. C57BL/6 wild-type or CD73(-/-) mice received a single dose of whole thorax irradiation (WTI, 15 Gy). Myeloid cells were characterized in flow cytometric, histologic, and immunohistochemical analyses as well as RNA analyses...
March 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28301631/androgen-receptor-function-and-androgen-receptor-targeted-therapies-in-breast-cancer-a-review
#19
Miho Kono, Takeo Fujii, Bora Lim, Meghan Sri Karuturi, Debasish Tripathy, Naoto T Ueno
Importance: The androgen receptor (AR) pathway is emerging as a potential therapeutic target in breast cancer. To date, AR-targeted drugs have been approved only for treatment of prostate cancer; however, AR-targeted treatment for breast cancer is an area of active investigation. Through review of preclinical studies, retrospective clinical studies, and clinical trials, we examined the biology of AR and AR-related pathways, the potential for AR-targeted therapies in breast cancer, and potential biomarkers for AR-targeted treatments...
March 16, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28292731/pathway-cross-talk-network-analysis-identifies-critical-pathways-in-neonatal-sepsis
#20
Yu-Xiu Meng, Quan-Hong Liu, Deng-Hong Chen, Ying Meng
BACKGROUND: Despite advances in neonatal care, sepsis remains a major cause of morbidity and mortality in neonates worldwide. Pathway cross-talk analysis might contribute to the inference of the driving forces in bacterial sepsis and facilitate a better understanding of underlying pathogenesis of neonatal sepsis. OBJECTIVE: This study aimed to explore the critical pathways associated with the progression of neonatal sepsis by the pathway cross-talk analysis. METHODS: By integrating neonatal transcriptome data with known pathway data and protein-protein interaction data, we systematically uncovered the disease pathway cross-talks and constructed a disease pathway cross-talk network for neonatal sepsis...
February 27, 2017: Computational Biology and Chemistry
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