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https://www.readbyqxmd.com/read/29141558/modulation-of-cancer-metabolism-by-phytochemicals-a-brief-overview
#1
Danina Muntean, Sturza Adrian, Ioana Pavel, Oana Duicu
Despite tremendous research efforts for effective therapies, cancer remains the plague of the century and its burden is expected to increase worldwide in the near future. Metabolic reprogramming is a firmly established hallmark of all cancers, regardless their cellular or tissue origin, being a prerequisite for both tumor growth and invasion. Functional dependence of tumors on glycolysis and glutaminolysis and the crucial contribution of mitochondria to the tumor bioenergetic versatility are well recognized features and established therapeutic targets...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29131747/linking-challenges-in-wound-healing-key-highlights-from-the-hartmann-congress
#2
(no author information available yet)
With a special focus on advanced wound healing (wound bed preparation, epithelialisation and hydration) and negative pressure wound therapy, the Hartmann LINK for Wound Healing Congress took place in Belfast, Northern Ireland, on 19 September. The event aimed to promote the latest advances in wound care and highlight the main challenges that clinicians face when treating different types of wounds. Annabel De Coster, editor of the British Journal of Community Nursing, gives an overview of selected talks from the congress...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29130367/development-and-evaluation-of-the-dignity-talk-question-framework-for-palliative-patients-and-their-families-a-mixed-methods-study
#3
Qiaohong Guo, Harvey Max Chochinov, Susan McClement, Genevieve Thompson, Tom Hack
BACKGROUND: Effective patient-family communication can reduce patients' psychosocial distress and relieve family members' current suffering and their subsequent grief. However, terminally ill patients and their family members often experience great difficulty in communicating their true feelings, concerns, and needs to each other. AIM: To develop a novel means of facilitating meaningful conversations for palliative patients and family members, coined Dignity Talk, explore anticipated benefits and challenges of using Dignity Talk, and solicit suggestions for protocol improvement...
October 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29119731/development-and-current-clinical-application-of-ventricular-assist-devices-in-china
#4
Yue Wu, Liang-Fan Zhu, Yun Luo
Heart failure has become one of the biggest threats to human health. Transplantation remains the most effective therapy for heart failure, but because of the shortage of donors, it cannot meet the demand. Ventricular assist devices (VADs) were developed to treat heart failure, and have now been clinically applied worldwide. As the country with the largest population, China is also facing the threat of heart failure. However, the development of VADs in China is very slow and is seldom discussed. This paper first talks about the background for VAD development in China...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29109513/targeting-androgen-receptor-in-treating-her2-positive-breast-cancer
#5
Licai He, Zhuanyun Du, Xusheng Xiong, Hua Ma, Zhenfeng Zhu, Hongwei Gao, Jiawei Cao, Tong Li, Hongzhi Li, Kaiyan Yang, Guorong Chen, Jennifer K Richer, Haihua Gu
Androgen receptor (AR) is widely expressed in different subtypes of breast cancer (BC). However, it is unclear how AR functions in HER2 positive (+) BC. Knockdown of AR with shRNAs and a new generation anti-androgen drug, Enzalutamide, were used to explore the involvement of AR on the growth of HER2 + BC cells (HCC1954 and SKBR3). AR shRNA or Enzalutamide inhibited the growth of SKBR3 cells at a similar extend compared to trastuzumab, an approved HER2 targeted drug. Combining Enzalutamide with trastuzumab further decreased the growth of HCC1954 and SKBR3 cells compared with single agent alone in vitro...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29109492/yes-we-are-still-talking-about-cylosporin-vs-infliximab-in-steroid-resistant-acute-severe-ulcerative-colitis
#6
Charles N Bernstein, Asher Kornbluth
The Spanish IBD Registry (ENEIDA) is reporting in this issue of the Journal on a retrospective assessment of outcomes of cyclosporine use and infliximab use to treat steroid refractory acute severe ulcerative colitis (SR-ASUC) between 1989 and 2013. Overall, they found similar outcomes in terms of 3 month and 1 year colectomy rates. Serious adverse events were lower in cyclosporine users. While this study does not meet the standard of a prospective randomized controlled trial, it does remind us that cyclosporine can be effective in (SR-ASUC) and should be considered in those who have already failed antibody to tumor necrosis factor therapy or as a bridge to immunomodulators that have a slower onset of action...
November 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29105980/extracellular-vesicles-in-the-adaptive-process-of-prostate-cancer-during-inhibition-of-androgen-receptor-signalling-by-enzalutamide
#7
Carolina Soekmadji, Anja Rockstroh, Grant A Ramm, Colleen C Nelson, Pamela J Russell
Current treatments for advanced prostate cancer focus on inhibition of the androgen receptor (AR) by androgen deprivation therapy (ADT). However, complex interactions mediated by tumour suppressors, oncogenes, aberrations of AR expression, or de novo androgen production have been shown to induce the adaptive response of prostate cancer, leading to the development of castration resistant prostate cancer (CRPC). In this study, we report the effects of AR antagonist, enzalutamide on the protein contents of extracellular vesicles (EVs)...
November 6, 2017: Proteomics
https://www.readbyqxmd.com/read/29100896/liver-disease-and-heart-failure-back-and-forth
#8
REVIEW
Michele Correale, Nicola Tarantino, Rossella Petrucci, Lucia Tricarico, Irma Laonigro, Matteo Di Biase, Natale Daniele Brunetti
In their clinical practice, physicians can face heart diseases (chronic or acute heart failure) affecting the liver and liver diseases affecting the heart. Systemic diseases can also affect both heart and liver. Therefore, it is crucial in clinical practice to identify complex interactions between heart and liver, in order to provide the best treatment for both. In this review, we sought to summarize principal evidence explaining the mechanisms and supporting the existence of this complicate cross-talk between heart and liver...
October 31, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29097671/functional-coupling-of-human-pancreatic-islets-and-liver-spheroids-on-a-chip-towards-a-novel-human-ex-vivo-type-2-diabetes-model
#9
Sophie Bauer, Charlotte Wennberg Huldt, Kajsa P Kanebratt, Isabell Durieux, Daniela Gunne, Shalini Andersson, Lorna Ewart, William G Haynes, Ilka Maschmeyer, Annika Winter, Carina Ämmälä, Uwe Marx, Tommy B Andersson
Human in vitro physiological models studying disease and drug treatment effects are urgently needed as more relevant tools to identify new drug targets and therapies. We have developed a human microfluidic two-organ-chip model to study pancreatic islet-liver cross-talk based on insulin and glucose regulation. We have established a robust co-culture of human pancreatic islet microtissues and liver spheroids maintaining functional responses up to 15 days in an insulin-free medium. Functional coupling, demonstrated by insulin released from the islet microtissues in response to a glucose load applied in glucose tolerance tests on different days, promoted glucose uptake by the liver spheroids...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29097609/recent-advances-of-cell-cycle-inhibitor-therapies-for-pediatric-cancer
#10
REVIEW
Christopher C Mills, E A Kolb, Valerie B Sampson
This review describes the pivotal roles of cell-cycle and checkpoint regulators and discusses development of specific cell-cycle inhibitors for therapeutic use for pediatric cancer. The mechanism of action as well as the safety and tolerability of drugs in pediatric patients, including compounds that target CDK4/CDK6 (palbociclib, ribociclib, and abemaciclib), aurora kinases (AT9283 and MLN8237), Wee1 kinase (MK-1775), KSP (ispinesib), and tubulin (taxanes, vinca alkaloids), are presented. The design of mechanism-based combinations that exploit the cross-talk of signals activated by cell-cycle arrest, as well as pediatric-focused drug development, are critical for the advancement of drugs for rare childhood diseases...
November 2, 2017: Cancer Research
https://www.readbyqxmd.com/read/29096891/association-of-cytokines-and-chemokines-in-pathogenesis-of-breast-cancer
#11
Jeronay King, Hina Mir, Shailesh Singh
Breast cancer touches women's life worldwide. Expected outcome is not achieved due to molecular heterogeneity and complex biology despite substantial advancement in diagnosis, prevention and treatment of breast cancer. Patients with estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (Her2) positive tumors receive hormone ablation and Her2 directed therapy. While patients diagnosed with triple-negative breast cancer receive chemotherapy in both the early and advanced stages...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29081191/-analysis-on-tyrosine-kinase-inhibitor-discontinuation-in-patients-with-chronic-myeloid-leukemia-in-the-real-world-experience-from-single-center
#12
L Yu, Y Z Qin, Q Jiang
Objective: To explore status of tyrosine kinase inhibitor (TKI) discontinuation in patients with chronic myeloid leukemia (CML) in the chronic phase (CP) in the real world, to analyze causes, factors and outcomes associated with TKI discontinuation and the possibility of pursuit treatment-free remission (TFR) in China. Methods: From January 2013 to August 2016, data of CML-CP patients in Peking University People's Hospital which were not enrolled in clinical trials were retrospectively collected and analyzed...
September 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29080342/cross-talk-between-bile-acids-and-gastro-intestinal-and-thermogenic-clues-from-bariatric-surgery
#13
Gabriella Garruti, Agostino Di Ciaula, Helen H Wang, David Q-H Wang, Piero Portincasa
Obesity is rapidly increasing and has reached epidemic features worldwide. It´s linked to insulin resistance, systemic low-grade inflammation and common pathogenic pathways with a number of comorbidities (including cancer), leading to high mortality rates. Besides change of lifestyles (diet and physical exercise) and pharmacological therapy, bariatric surgery is able to rapidly improve several metabolic and morphologic features associated with excessive fat storage, and currently represents an in vivo model to study the pathogenic mechanisms underlying obesity and obesity-related complications...
October 28, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29078133/androgen-receptor-in-estrogen-receptor-positive-breast-cancer-beyond-expression
#14
REVIEW
Debora Basile, Marika Cinausero, Donatella Iacono, Giacomo Pelizzari, Marta Bonotto, Maria Grazia Vitale, Lorenzo Gerratana, Fabio Puglisi
In recent years, new therapeutic approaches have reshaped the overall strategy of breast cancer (BC) treatment and have markedly improved patient survival. This is, in part, due to novel therapies for estrogen receptor (ER)-positive BC. Unfortunately, many patients present de novo resistance to these therapies or develop an acquired resistance over time. Therefore, research is now focused on discovering new molecular targets to overcome these resistances. Interestingly, preclinical and clinical studies have shown a critical role for the cross-talk between androgen receptor (AR) and ER in luminal-like BC...
October 6, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29075508/effect-of-alginate-concentration-on-chondrogenesis-of-co-cultured-human-adipose-derived-stem-cells-and-nasal-chondrocytes-a-biological-study
#15
Y W Ewa-Choy, B Pingguan-Murphy, N A Abdul-Ghani, J Jahendran, K H Chua
BACKGROUND: The three-dimensional (3D) system is one of the important factors to engineer a biocompatible and functional scaffold for the applications of cell-based therapies for cartilage repair. The 3D alginate hydrogels system has previously been shown to potentially promote chondrogenesis. The chondrocytic differentiation of co-cultured adipose-derived stem cells (ADSCs) and nasal chondrocytes (NCs) within alginate constructs are hypothesized to be influenced by concentration of alginate hydrogel...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29072515/interactions-between-metabolic-reward-and-cognitive-processes-in-appetite-control-implications-for-novel-weight-management-therapies
#16
Suzanne Higgs, Maartje S Spetter, Jason M Thomas, Pia Rotshtein, Michelle Lee, Manfred Hallschmid, Colin T Dourish
Traditional models of appetite control have emphasised the role of parallel homeostatic and hedonic systems, but more recently the distinction between independent homeostatic and hedonic systems has been abandoned in favour of a framework that emphasises the cross talk between the neurochemical substrates of the two systems. In addition, evidence has emerged more recently, that higher level cognitive functions such as learning, memory and attention play an important role in everyday appetite control and that homeostatic signals also play a role in cognition...
October 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29069787/proteasome-inhibitors-prevent-bi-directional-her2-estrogen-receptor-cross-talk-leading-to-cell-death-in-endocrine-and-lapatinib-resistant-her2-er-breast-cancer-cells
#17
Sonja Thaler, Marcus Schmidt, Sven Roβwag, Gitta Thiede, Arno Schad, Jonathan P Sleeman
Amplification and/or overexpression of the human epidermal growth factor 2 (HER2) oncogene occurs in about 13-15% of invasive breast cancer and triggers breast cancer cell proliferation, survival and metastatic progression. Around half of all breast cancers with HER2 overexpression co-express hormone receptors (HR) such as those for estrogen and progesterone. Aberrant signaling through HER2 and other members of the HER-family mediates endocrine-resistance in estrogen receptor alpha (ERα) positive breast cancer...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29063389/building-psychosocial-capacity-through-training-of-front-line-health-professionals-to-provide-brief-therapy-lessons-learned-from-the-prompt-study
#18
Jane Turner, Lisa Mackenzie, Brian Kelly, David Clarke, Patsy Yates, Sanchia Aranda
PURPOSE: This report describes the views of front-line health professionals who participated in a randomised controlled trial examining a model of care in which depressed cancer patients received a brief psychosocial intervention. Health professionals from four cancer centres received focused training, skill development and clinical supervision in order to deliver the intervention. METHODS: We interviewed 20 health professionals asking them about their perceptions of participation in the study and their views about more widespread implementation of this model of care...
October 23, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29054289/cross-talk-between-the-epigenome-and-neural-circuits-in-drug-addiction
#19
Philipp Mews, Erin S Calipari
Drug addiction is a behavioral disorder characterized by dysregulated learning about drugs and associated cues that result in compulsive drug seeking and relapse. Learning about drug rewards and predictive cues is a complex process controlled by a computational network of neural connections interacting with transcriptional and molecular mechanisms within each cell to precisely guide behavior. The interplay between rapid, temporally specific neuronal activation, and longer-term changes in transcription is of critical importance in the expression of appropriate, or in the case of drug addiction, inappropriate behaviors...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29051371/adrenergic-nerves-activate-an-angio-metabolic-switch-in-prostate-cancer
#20
Ali H Zahalka, Anna Arnal-Estapé, Maria Maryanovich, Fumio Nakahara, Cristian D Cruz, Lydia W S Finley, Paul S Frenette
Nerves closely associate with blood vessels and help to pattern the vasculature during development. Recent work suggests that newly formed nerve fibers may regulate the tumor microenvironment, but their exact functions are unclear. Studying mouse models of prostate cancer, we show that endothelial β-adrenergic receptor signaling via adrenergic nerve-derived noradrenaline in the prostate stroma is critical for activation of an angiogenic switch that fuels exponential tumor growth. Mechanistically, this occurs through alteration of endothelial cell metabolism...
October 20, 2017: Science
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