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https://www.readbyqxmd.com/read/27871326/tryptophan-hydroxylase-1-and-5-ht7-receptor-preferentially-expressed-in-triple-negative-breast-cancer-promote-cancer-progression-through-autocrine-serotonin-signaling
#1
Jaya Gautam, Suhrid Banskota, Sushil Chandra Regmi, Subi Ahn, Yong Hyun Jeon, Hyunyoung Jeong, Seung Joo Kim, Tae-Gyu Nam, Byeong-Seon Jeong, Jung-Ae Kim
BACKGROUND: Triple-negative breast cancer (TNBC) has a high risk of relapse and there are few chemotherapy options. Although 5-hydroxytryptamine (5-HT, serotonin) signaling pathways have been suggested as potential targets for anti-cancer drug development, the mechanism responsible for the action of 5-HT in TNBC remains unknown. METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to measure mRNA and protein levels, respectively...
November 21, 2016: Molecular Cancer
https://www.readbyqxmd.com/read/27850750/1113-an-asthma-score-with-high-interobserver-agreement-for-use-in-a-multidisciplinary-treatment-guideline
#2
Cassandra Louis, Georgia Christakis, Yudy Fonseca, Genevieve Alonge, Peter Eldridge, Qiuhu Shi, John Welter, Simon Li
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27820160/cross-centre-replication-of-suppressed-burrowing-behaviour-as-an-ethologically-relevant-pain-outcome-measure-in-the-rat-a-prospective-multicentre-study
#3
Rachel Wodarski, Ada Delaney, Camilla Ultenius, Rosie Morland, Nick Andrews, Catherine Baastrup, Luke A Bryden, Ombretta Caspani, Thomas Christoph, Natalie J Gardiner, Wenlong Huang, Jeffrey D Kennedy, Suguru Koyama, Dominic Li, Marcin Ligocki, Annika Lindsten, Ian Machin, Anton Pekcec, Angela Robens, Sanziana M Rotariu, Sabrina VoB, Marta Segerdahl, Carina Stenfors, Camilla I Svensson, Rolf-Detlef Treede, Katsuhiro Uto, Kazumi Yamamoto, Kris Rutten, Andrew S C Rice
Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model of inflammatory pain (unilateral, 1 mg/mL in 100 µL) was evaluated in 11 studies across 8 centres. Following a standard protocol, data from participating centres were collected centrally and analysed with a restricted maximum likelihood-based mixed model for repeated measures...
October 2016: Pain
https://www.readbyqxmd.com/read/27805727/reference-intervals-for-biochemical-blood-variables-packed-cell-volume-and-body-temperature-in-pet-rats-rattus-norvegicus-using-point-of-care-testing
#4
Anneleen Houtmeyers, Luc Duchateau, Bettina Grünewald, Katleen Hermans
BACKGROUND: Rats (Rattus norvegicus) are increasingly kept as pets, thus more and more requiring veterinary care. Important differences exist between pet and laboratory rats, but little information is available on pet rats. Diagnosis and treatment of pet rat diseases would benefit from RIs specific for this animal population. OBJECTIVES: The aim was to establish RIs for biochemical blood variables, PCV, and body temperature in pet rats. Additionally, influences of sex and feed rationing method (ad libitum, restricted) on these variables were determined...
November 2, 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27773885/involvement-of-dna-methylation-in-regulating-rat-prop1-gene-expression-during-pituitary-organogenesis
#5
Hiroto Nishihara, Saishu Yoshida, Naoko Kanno, Naoto Nishimura, Hiroki Ueharu, Jun Ohgane, Takako Kato, Yukio Kato
PROP1 is a pituitary specific transcription factor that plays a crucial role in pituitary organogenesis. The Prop1 shows varied expression patterns that promptly emerge and then fade during the early embryonic period. However, the regulatory mechanisms governing Prop1 expression remain unclear. Here, we investigated whether Prop1 was under epigenetic regulation by DNA methylation. Bisulfite sequencing was performed on DNA obtained from the pituitary glands and livers of rats on embryonic days (E) 13.5 and E14...
October 21, 2016: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/27758036/potentially-preventable-deaths-in-the-victorian-audit-of-surgical-mortality
#6
Andrew Chen, Claudia Retegan, Jessele Vinluan, Charles Barry Beiles
BACKGROUND: The Victorian Audit of Surgical Mortality (VASM) seeks to peer-review all deaths associated with surgical care. This study aimed to examine the mortalities that were determined by the assessor to be potentially preventable, and identify the clinical factors associated with these cases. The assessment of preventability of death and its relationship to management issues at different stages of the admission episode, as opposed to whether the management issue(s) alone were preventable have not been reported previously...
October 18, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27658384/the-association-between-dog-walking-physical-activity-and-owner-s-perceptions-of-safety-cross-sectional-evidence-from-the-us-and-australia
#7
Hayley Christian, Lisa Wood, Andrea Nathan, Ichiro Kawachi, Stephen Houghton, Karen Martin, Sandra McCune
BACKGROUND: We examined the relationship between dog walking and physical activity within and between four US cities and Australia and investigated if dog walking is associated with higher perceived safety in US and Australian cities. METHODS: Dog owners (n = 1113) in the Pet Connections Study completed a cross-sectional survey. Data were collected across four study sites; three in the US (San Diego, Nashville, Portland) and a fourth in Australia (Perth). Physical activity, local walking, dog walking, and individual and community perceptions of safety were analysed for dog walkers and non-dog walkers for each study site...
September 22, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27643836/cross-centre-replication-of-suppressed-burrowing-behaviour-as-an-ethologically-relevant-pain-outcome-measure-in-the-rat-a-prospective-multicentre-study
#8
Rachel Wodarski, Ada Delaney, Camilla Ultenius, Rosie Morland, Nick Andrews, Catherine Baastrup, Luke A Bryden, Ombretta Caspani, Thomas Christoph, Natalie J Gardiner, Wenlong Huang, Jeffrey D Kennedy, Suguru Koyama, Dominic Li, Marcin Ligocki, Annika Lindsten, Ian Machin, Anton Pekcec, Angela Robens, Sanziana M Rotariu, Sabrina Vo, Marta Segerdahl, Carina Stenfors, Camilla I Svensson, Rolf-Detlef Treede, Katsuhiro Uto, Kazumi Yamamoto, Kris Rutten, Andrew S C Rice
Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model of inflammatory pain (unilateral, 1 mg/mL in 100 µL) was evaluated in 11 studies across 8 centres. Following a standard protocol, data from participating centres were collected centrally and analysed with a restricted maximum likelihood-based mixed model for repeated measures...
October 2016: Pain
https://www.readbyqxmd.com/read/27622515/trigger-oriented-hiv-testing-at-internal-medicine-hospital-departments-in-northern-italy-an-observational-study-fo-c-s-study
#9
Carlo Cerini, Salvatore Casari, Francesco Donato, Enzo Porteri, Anna Rodella, Luigina Terlenghi, Silvia Compostella, Alessandra Apostoli, Nigritella Brianese, Lucia Urbinati, Andrea Salvi, Angelo Rossini, Enrico Agabiti Rosei, Arnaldo Caruso, Giampiero Carosi, Francesco Castelli
BACKGROUND: Early detection of undiagnosed HIV infected patients is of paramount importance. The attitude of Italian hospital-based Internal Medicine physicians to prescribe HIV testing following the detection of HIV-associated signs, symptoms and behaviours (triggers) has been reported to be poor. The aim of the study is to quantify the extent of the missed opportunities for early HIV diagnosis in Internal Medicine Departments (IMD). METHODS: Patients admitted to IMD of a General University Hospital in Italy in March-June 2013 were interviewed using a structured questionnaire investigating the presence of triggers for HIV testing, including patient's characteristics, symptoms and conditions associated with HIV infection...
November 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27584269/does-arterial-oxygen-saturation-influence-the-relationship-between-hemoglobin-mass-and-vo2peak-at-moderate-altitude-1113-board-2-june-1-3-15-pm-5-15-pm
#10
Jesse A Goodrich, Benjamin J Ryan, William C Byrnes
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27576896/expression-purification-and-characterization-of-an-endoglucanase-from-serratia-proteamaculans-cdbb-1961-isolated-from-the-gut-of-dendroctonus-adjunctus-coleoptera-scolytinae
#11
Claudia Cano-Ramírez, Alejandro Santiago-Hernández, Flor Nohemí Rivera-Orduña, Yolanda García-Huante, Gerardo Zúñiga, María Eugenia Hidalgo-Lara
Serratia proteamaculans CDBB-1961, a gut symbiont from the roundheaded pine beetle Dendroctonus adjunctus, displayed strong cellulolytic activity on agar-plates with carboxymethyl cellulose (CMC) as carbon source. Automatic genome annotation of S. proteamaculans made possible the identification of a single endoglucanase encoding gene, designated spr cel8A. The predicted protein, named Spr Cel8A shows high similarity (59-94 %) to endo-1,4-β-D-glucanases (EC 3.2.1.4) from the glycoside hydrolase family 8 (GH8)...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27557984/reactions-to-testing-hiv-negative-measurement-and-associations-with-sexual-risk-behaviour-among-young-msm-who-recently-tested-hiv-negative
#12
Brian A Feinstein, Brent A Johnson, Jeffrey T Parsons, Brian Mustanski
Receiving an HIV-positive test result is associated with reduced condomless anal sex (CAS), but little is known about negative test results. The recent development of the Inventory of Reactions to Testing HIV Negative confirmed that there are diverse reactions to receiving a negative test result, which have implications for risk behaviour. The goals of the current study were to validate the measure in a sample of young men who have sex with men who recently tested HIV-negative (N = 1113) and to examine its associations with CAS...
August 24, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27554185/maternal-characteristics-associated-with-the-obesogenic-quality-of-the-home-environment-in-early-childhood
#13
Stephanie Schrempft, Cornelia H M van Jaarsveld, Abigail Fisher, Alison Fildes, Jane Wardle
The home environment is likely to influence children's diet and activity patterns and ultimately, their weight trajectories. Identifying family characteristics associated with a more 'obesogenic' home can provide insight into the determinants, and has implications for targeting and tailoring strategies to promote healthier lifestyles. The present study examined maternal characteristics associated with a more obesogenic home environment in 1113 families with preschool children. Primary caregivers (99% mothers) from the Gemini cohort completed the Home Environment Interview (HEI) when their children were 4 years old...
December 1, 2016: Appetite
https://www.readbyqxmd.com/read/27552280/a-community-powered-asset-based-approach-to-intersectoral-urban-health-system-planning-in-chicago
#14
Stacy Tessler Lindau, Katherine Diaz Vickery, HwaJung Choi, Jennifer Makelarski, Amber Matthews, Matthew Davis
OBJECTIVES: To describe, and provide a nomenclature and taxonomy for classifying, the economic sectors and functional assets that could be mobilized as partners in an intersectoral health system. METHODS: MAPSCorps (Meaningful, Active, Productive Science in Service to Community) employed local youths to conduct a census of all operating assets (businesses and organizations) on the South Side of Chicago, Illinois, in 2012. We classified assets by primary function into sectors and described asset and sector distribution and density per 100 000 population...
October 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27515663/genome-wide-identification-of-potato-long-intergenic-noncoding-rnas-responsive-to-pectobacterium-carotovorum-subspecies-brasiliense-infection
#15
Stanford Kwenda, Paul R J Birch, Lucy N Moleleki
BACKGROUND: Long noncoding RNAs (lncRNAs) represent a class of RNA molecules that are implicated in regulation of gene expression in both mammals and plants. While much progress has been made in determining the biological functions of lncRNAs in mammals, the functional roles of lncRNAs in plants are still poorly understood. Specifically, the roles of long intergenic nocoding RNAs (lincRNAs) in plant defence responses are yet to be fully explored. RESULTS: In this study, we used strand-specific RNA sequencing to identify 1113 lincRNAs in potato (Solanum tuberosum) from stem tissues...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27494079/pre-and-perinatal-complications-in-relation-to-tourette-syndrome-and-co-occurring-obsessive-compulsive-disorder-and-attention-deficit-hyperactivity-disorder
#16
Mohamed Abdulkadir, Jay A Tischfield, Robert A King, Thomas V Fernandez, Lawrence W Brown, Keun-Ah Cheon, Barbara J Coffey, Sebastian F T M de Bruijn, Lonneke Elzerman, Blanca Garcia-Delgar, Donald L Gilbert, Dorothy E Grice, Julie Hagstrøm, Tammy Hedderly, Isobel Heyman, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Young Key Kim, Young-Shin Kim, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Andreas Lamerz, Bennett Leventhal, Andrea G Ludolph, Marcos Madruga-Garrido, Athanasios Maras, Marieke D Messchendorp, Pablo Mir, Astrid Morer, Alexander Münchau, Tara L Murphy, Thaïra J C Openneer, Kerstin J Plessen, Judith J G Rath, Veit Roessner, Odette Fründt, Eun-Young Shin, Deborah A Sival, Dong-Ho Song, Jungeun Song, Anne-Marie Stolte, Jennifer Tübing, Els van den Ban, Frank Visscher, Sina Wanderer, Martin Woods, Samuel H Zinner, Matthew W State, Gary A Heiman, Pieter J Hoekstra, Andrea Dietrich
Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study...
November 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27486199/phosphoproteomics-to-characterize-host-response-during-influenza-a-virus-infection-of-human-macrophages
#17
Sandra Söderholm, Denis E Kainov, Tiina Öhman, Oxana V Denisova, Bert Schepens, Evgeny Kulesskiy, Susumu Y Imanishi, Garry Corthals, Petteri Hintsanen, Tero Aittokallio, Xavier Saelens, Sampsa Matikainen, Tuula A Nyman
Influenza A viruses cause infections in the human respiratory tract and give rise to annual seasonal outbreaks, as well as more rarely dreaded pandemics. Influenza A viruses become quickly resistant to the virus-directed antiviral treatments, which are the current main treatment options. A promising alternative approach is to target host cell factors that are exploited by influenza viruses. To this end, we characterized the phosphoproteome of influenza A virus infected primary human macrophages to elucidate the intracellular signaling pathways and critical host factors activated upon influenza infection...
October 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27484461/construction-and-internal-validation-of-a-new-mortality-risk-score-for-patients-admitted-to-the-intensive-care-unit
#18
Cristina Dólera-Moreno, Antonio Palazón-Bru, Francisco Colomina-Climent, Vicente Francisco Gil-Guillén
BACKGROUND: The existing models to predict mortality in intensive care units (ICU) present difficulties in clinical practice. OBJECTIVES: The aim of this study was to develop and internally validate a points system to predict mortality in the ICU, which can be applied instantly and with high discriminating power. METHODS: This cohort study comprised all patients admitted to the ICU in a Spanish region between January 2013 and April 2014, followed from admission to death or discharge (N=1113)...
November 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27469516/anxiety-and-depression-strongly-associated-with-sexual-risk-behaviors-among-networks-of-young-men-in-dar-es-salaam-tanzania
#19
Lauren M Hill, Suzanne Maman, Mrema Noel Kilonzo, Lusajo Joel Kajula
This study tested the association between mental health scores and sexual risk behaviors among male members of social groups known as "camps" in Dar es Salaam, Tanzania. Anxiety and depression were measured using the HSCL-25 and condom use and sexual partner concurrency were assessed through self-report. A total of 1113 sexually active men with an average age of 27 years were included in the analyses. Higher anxiety and depression scores were significantly associated with both condom use (Anxiety AOR = 0...
July 28, 2016: AIDS Care
https://www.readbyqxmd.com/read/27449271/use-of-multiple-tobacco-products-in-a-national-sample-of-persons-enrolled-in-addiction-treatment
#20
Joseph Guydish, Barbara Tajima, Sowmya Pramod, Thao Le, Noah R Gubner, Barbara Campbell, Paul Roman
OBJECTIVE: To explore use of tobacco products in relationship to marketing exposure among persons in addiction treatment. METHOD: A random sample of treatment programs was drawn from the National Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN). Participants in each program completed surveys concerning use of tobacco products (N=1113). Exposure to tobacco marketing and counter-marketing, advertising receptivity, and perceived health risks of smoking were tested for their association with use of multiple tobacco products...
September 1, 2016: Drug and Alcohol Dependence
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