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https://www.readbyqxmd.com/read/29655571/a-rapid-access-chest-pain-clinic-racpc-initial-australian-experience
#1
C Yu, M J Sheriff, A C C Ng, S Brazete, J Gullick, D B Brieger, L Kritharides, H C Lowe
Chest pain is the second most common presenting symptom to emergency departments (ED) in Australia, although up to 85% of these patients do not have an acute coronary syndrome (ACS). Cardiologist-led rapid access chest pain clinics (RACPC) have been proposed overseas to assist in the management of such patients, with prompt outpatient assessment if patients are deemed low risk and discharged from the ED. The use of RACPCs in Australia has been only recently proposed; we therefore sought to examine one such RACPC in an Australian context...
December 11, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29652881/the-simultaneous-assessment-of-glycosylated-hemoglobin-fasting-plasma-glucose-and-oral-glucose-tolerance-test-does-not-improve-the-detection-of-type-2-diabetes-mellitus-in-colombian-adults
#2
Jose Lopez-Lopez, Jennifer Garay, Edwin Wandurraga, Paul A Camacho, Fernando Higuera-Escalante, Daniel Cohen, Patricio Lopez-Jaramillo
INTRODUCTION: Guidelines recommend early detection of type 2 diabetes mellitus (DM2). The objective of the present study was to evaluate the capacity to identify DM2 in subjects that were screened for DM2 simultaneously with all three of the tests recommended-fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and a 2-hour post 75-g oral glucose tolerance test (OGTT). METHODS AND RESULTS: The present analysis of an anonymous database of 1113 adults from a reference clinical laboratory in Bucaramanga, Colombia, was an observational, descriptive, cross-sectional secondary source study...
2018: PloS One
https://www.readbyqxmd.com/read/29606048/relationship-between-tumor-location-size-and-who-grade-in-meningioma
#3
Stephen T Magill, Jacob S Young, Ricky Chae, Manish K Aghi, Philip V Theodosopoulos, Michael W McDermott
OBJECTIVE Prior studies have investigated preoperative risk factors for meningioma; however, no association has been shown between meningioma tumor size and tumor grade. The objective of this study was to investigate the relationship between tumor size and grade in a large single-center study of patients undergoing meningioma resection. METHODS A retrospective chart review of patients undergoing meningioma resection at the University of California, San Francisco, between 1985 and 2015 was performed. Patients with incomplete information, spinal meningiomas, multiple meningiomas, or WHO grade III meningiomas were excluded...
April 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29581131/higher-absolute-lymphocyte-counts-predict-lower-mortality-from-early-stage-triple-negative-breast-cancer
#4
Anosheh Afghahi, Natasha Purington, Summer S Han, Manisha Desai, Emma Pierson, Maya B Mathur, Tina Seto, Caroline A Thompson, Joseph Rigdon, Melinda L Telli, Sunil S Badve, Christina Curtis, Robert B West, Kathleen Horst, Scarlett Lin Gomez, James M Ford, George W Sledge, Allison W Kurian
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) in pre-treatment biopsies are associated with improved survival in triple-negative breast cancer (TNBC). We investigated whether higher peripheral lymphocyte counts are associated with lower breast cancer-specific mortality (BCM) and overall mortality (OM) in TNBC. METHODS: Data on treatments and diagnostic tests from electronic medical records of two healthcare systems were linked with demographic, clinical, pathologic, and mortality data from the California Cancer Registry...
March 26, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29566187/sweet-taste-exposure-and-the-subsequent-acceptance-and-preference-for-sweet-taste-in-the-diet-systematic-review-of-the-published-literature
#5
K M Appleton, H Tuorila, E J Bertenshaw, C de Graaf, D J Mela
Background: There are consistent, evidence-based global public health recommendations to reduce intakes of free sugars. However, the corresponding evidence for recommending reduced exposure to sweetness is less clear. Objective: Our aim was to identify and review the published evidence investigating the impact of dietary exposure to sweet-tasting foods or beverages on the subsequent generalized acceptance, preference, or choice of sweet foods and beverages in the diet...
March 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29558897/upregulation-of-genes-encoding-digestive-enzymes-and-nutrient-transporters-in-the-digestive-system-of-broiler-chickens-by-dietary-supplementation-of-fiber-and-inclusion-of-coarse-particle-size-corn
#6
Sarbast K Kheravii, Robert A Swick, Mingan Choct, Shu-Biao Wu
BACKGROUND: Measures to improve bird performance have been sought due to the imminent phase out of in-feed antibiotics in poultry and continued demand for higher poultry feeding efficiency. Increasing grain particle size and dietary fibre may improve gizzard function, digestive efficiency and nutrient absorption. This study was conducted to evaluate the effect increased particle size of corn and inclusion of sugarcane bagasse (SB) on mRNA expression of genes encoding digestive enzymes and nutrient transporters in broilers...
March 20, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29529072/growth-differentiation-factor-15-levels-and-the-risk-of-contrast-induced-acute-kidney-injury-in-acute-myocardial-infarction-patients-treated-invasively-a-propensity-score-match-analysis
#7
Ling Sun, Xuejun Zhou, Jianguang Jiang, Xuan Zang, Xin Chen, Haiyan Li, Haitao Cao, Qingjie Wang
BACKGROUND: Growth differentiation factor-15 (GDF-15) is an emerging biomarker for risk stratification in cardiovascular disease. Contrast-induced acute kidney injury (AKI) is an important complication in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI). In this retrospectively observational study, we aimed to determine the role of GDF-15 and the risk of AKI in acute myocardial infarction (AMI) patients. METHODS: The medical records of 1195 patients with AMI were reviewed...
2018: PloS One
https://www.readbyqxmd.com/read/29503450/prevalence-of-diabetic-retinopathy-and-visual-impairment-in-patients-with-diabetes-mellitus-in-zambia-through-the-implementation-of-a-mobile-diabetic-retinopathy-screening-project-in-the-copperbelt-province-a-cross-sectional-study
#8
Adam D Lewis, Ruth E Hogg, Manju Chandran, Lillian Musonda, Lorraine North, Usha Chakravarthy, Sobha Sivaprasad, Geeta Menon
AIMS: A paucity of literature exists on prevalence of diabetic retinopathy (DR) in sub-Saharan Africa. We aim to estimate the prevalence of DR and visual impairment in Zambia's Copperbelt province through a cross-sectional study. METHODS: All patients with a diagnosis of diabetes mellitus attending a DR screening programme were eligible to participate. Fundus photographs were graded in accordance with the DR grading system used in the UK National Health service (NHS)...
March 5, 2018: Eye
https://www.readbyqxmd.com/read/29502989/subclinical-lyme-borreliosis-is-common-in-south-eastern-sweden-and-may-be-distinguished-from-lyme-neuroborreliosis-by-sex-age-and-specific-immune-marker-patterns
#9
Hanna Carlsson, Christina Ekerfelt, Anna J Henningsson, Lars Brudin, Ivar Tjernberg
BACKGROUND: Determinants of a subclinical course of Lyme borreliosis (LB) remain largely unknown. The aim of this study was to assess the extent, sex and age profiles of subclinical Borrelia seroconversion in a LB endemic area in Sweden and to map blood cellular Borrelia-specific immune marker patterns in individuals with a previous subclinical LB course compared with patients previously diagnosed with Lyme neuroborreliosis (LNB). METHODS: A large group of 1113 healthy blood donors was screened for multiple IgG anti-Borrelia antibodies and asked to complete a health inquiry regarding previous LB...
February 16, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29468257/aurora-kinase-b-regulates-axonal-outgrowth-and-regeneration-in-the-spinal-motor-neurons-of-developing-zebrafish
#10
Serene S L Gwee, Rowan A W Radford, Sharron Chow, Monisha D Syal, Marco Morsch, Isabel Formella, Albert Lee, Emily K Don, Andrew P Badrock, Nicholas J Cole, Adrian K West, Steve N S Cheung, Roger S Chung
Aurora kinase B (AurkB) is a serine/threonine protein kinase with a well-characterised role in orchestrating cell division and cytokinesis, and is prominently expressed in healthy proliferating and cancerous cells. However, the role of AurkB in differentiated and non-dividing cells has not been extensively explored. Previously, we have described a significant upregulation of AurkB expression in cultured cortical neurons following an experimental axonal transection. This is somewhat surprising, as AurkB expression is generally associated only with dividing cells Frangini et al...
February 21, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29429815/long-term-immunogenicity-of-an-initial-booster-dose-of-an-inactivated-vero-cell-culture-derived-japanese-encephalitis-vaccine-je-vc-and-the-safety-and-immunogenicity-of-a-second-je-vc-booster-dose-in-children-previously-vaccinated-with-an-inactivated-mouse
#11
Ki Wook Yun, Hoan Jong Lee, Ji Young Park, Hye-Kyung Cho, Yae-Jean Kim, Kyung-Hyo Kim, Nam Hee Kim, Young Jin Hong, Dong Ho Kim, Hwang Min Kim, Sung-Ho Cha
BACKGROUND: This study was performed with the aim of determining the long-term immunogenicity of an inactivated, Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) and an inactivated, mouse brain-derived JE vaccine (JE-MB) after the 1st booster dose at 2 years of age, as well as the safety and immunogenicity of the 2nd booster dose of JE-VC at 6 years of age, in children primed and given a 1st booster dose of either JE-VC or JE-MB. METHOD: In this multicenter, open-label clinical trial, the study population consisted of healthy Korean children (aged 6 years) who participated in the previous JE vaccine trial...
March 7, 2018: Vaccine
https://www.readbyqxmd.com/read/29413946/trichomonas-vaginalis-cathepsin-d-like-aspartic-proteinase-tv-catd-is-positively-regulated-by-glucose-and-degrades-human-hemoglobin
#12
Maria Inocente Mancilla-Olea, Jaime Ortega-López, Elisa E Figueroa-Angulo, Leticia Avila-González, Rosa Elena Cárdenas-Guerra, Jesús F T Miranda-Ozuna, Arturo González-Robles, Mar Saraí Hernández-García, Lizbeth Sánchez-Ayala, Rossana Arroyo
Trichomonas vaginalis genome encodes ∼440 proteases, six of which are aspartic proteases (APs). However, only one belongs to a clan AA (EC 3.4.23.5), family A1 (pepsin A), cathepsin D-like protease. This AP is encoded by an 1113-bp gene (tv-catd), which translates into a 370-aa residues zymogen of 40.7-kDa and a theoretical pI of 4.6, generating a ∼35 kDa active enzyme after maturation (Tv-CatD). The goal of this study was to identify and analyze the effect of glucose on the expression of Tv-CatD at the transcript and protein levels, subcellular localization, and proteolytic activity...
January 29, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29413941/effect-of-diclofenac-on-the-production-of-volatile-fatty-acids-from-anaerobic-fermentation-of-waste-activated-sludge
#13
Jiawei Hu, Jianwei Zhao, Dongbo Wang, Xiaoming Li, Dan Zhang, Qiuxiang Xu, Lai Peng, Qi Yang, Guangming Zeng
In this study, the impact of diclofenac (DCF), an antiinflammatory drug being extensively used in human health care and veterinary treatment, on the production of volatile fatty acids (VFAs) from anaerobic fermentation of waste activated sludge (WAS) was investigated for the first time. Experimental results showed that when DCF concentration increased from 2.5 to 25 mg/kg total suspended solid (TSS), the maximum production of VFAs increased from 599 to 1113 mg COD/L, but further increase of DCF to 47...
January 13, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29410275/the-comprehensive-expression-analysis-of-the-g-protein-coupled-receptor-from-penaeus-monodon-indicating-it-participates-in-innate-immunity-and-anti-ammonia-nitrogen-stress
#14
Dandan Zhu, Lishi Yang, Huang Jianhua, Zhou Falin, Yang Qibin, Jiang Song, Shigui Jiang
The G protein-coupled receptors (GPCRs) composed a superfamily that played an important role in physiological processes of crustaceans, with multiple functions such as growth and development, acting as a defense against stimulations from external factors. In this paper, one kind of GPCRs were identified from Penaeus monodon, called PmGPCR, included an open reading frame (ORF) of 1113 bp. Bioinformatic analysis showed that PmGPCR protein had the typical structure of seven transmembrane domains (7TM), especially the special Asp-Arg-Try motif (DRY motif) between the third transmembrane structures (TM3) and the second intracellular loops (IL-2) which can prove that PmGPCR belongs to the rhodopsin-like family...
February 1, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29406579/intraoperative-interventions-for-preventing-surgical-site-infection-an-overview-of-cochrane-reviews
#15
REVIEW
Zhenmi Liu, Jo C Dumville, Gill Norman, Maggie J Westby, Jane Blazeby, Emma McFarlane, Nicky J Welton, Louise O'Connor, Julie Cawthorne, Ryan P George, Emma J Crosbie, Amber D Rithalia, Hung-Yuan Cheng
BACKGROUND: Surgical site infection (SSI) rates vary from 1% to 5% in the month following surgery. Due to the large number of surgical procedures conducted annually, the costs of these SSIs can be considerable in financial and social terms. Many interventions are used with the aim of reducing the risk of SSI in people undergoing surgery. These interventions can be broadly delivered at three stages: preoperatively, intraoperatively and postoperatively. The intraoperative interventions are largely focused on decontamination of skin using soap and antiseptics; the use of barriers to prevent movement of micro-organisms into incisions; and optimising the patient's own bodily functions to promote best recovery...
February 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29388061/clinical-impact-of-pi3k-braf-mutations-in-ras-wild-metastatic-colorectal-cancer-meta-analysis-results
#16
Amr Mohamed, Brandon Twardy, Nadine AbdAllah, Alaa Akhras, Hibah Ismail, Magdi Zordok, Kelly Schrapp, Taraq Attumi, Anteneh Tesfaye, Bassel El-Rayes
BACKGROUND: Understanding the molecular mechanisms of colorectal cancer has evolved during the last decade ushering the era of personalized medicine. Alteration of BRAF and PI3K is common in colorectal cancer, and can affect several signaling pathways including EGFR (epidermal growth factor receptor). The aim of this meta-analysis is to evaluate the clinical role of PI3K and BRAF mutations in patients with KRAS wild-type metastatic colorectal cancer (MCRC) receiving an EGFR monoclonal antibody (anti-EGFR) inhibitor as first-line therapy...
February 1, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29372842/decreased-daytime-light-intensity-at-nonwindow-hospital-beds-comparisons-with-light-intensity-at-window-hospital-beds-and-light-exposure-in-nonhospitalized-elderly-individuals
#17
Junko Iwamoto, Kenji Obayashi, Miwa Kobayashi, Toshimichi Kotsuji, Rie Matsui, Kyoko Ito, Osamu Yoshida, Norio Kurumatani, Keigo Saeki
Light is crucial for the synchronization of internal biological rhythms with environmental rhythms. Hospitalization causes a range of unfavorable medical conditions, including delirium, sleep disturbances, depressed mood, and increased fall, especially in elderly people. The hospital room environment contributes significantly to patients' circadian physiology and behavior; however, few studies have evaluated light intensity in hospital settings. In this study, bedside light intensity during the daytime (6:00-21:00) was measured at 1-min intervals using a light meter on 4869 bed-days at the Inabe General Hospital in Mie, Japan (latitude 35°N), for approximately 1 month in each season...
January 26, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29316054/influence-of-body-mass-index-on-induction-of-labor-a-historical-cohort-study
#18
Ulf Dammer, Roswitha Bogner, Christel Weiss, Florian Faschingbauer, Jutta Pretscher, Matthias W Beckmann, Marc Sütterlin, Sven Kehl
AIM: We aimed to determine the influence of body mass index (BMI) on induction of labor. METHODS: In this historical multicenter cohort study, 2122 labor inductions were analyzed. Women were divided into four groups according to their body mass index (BMI): BMI < 30 (normal group [NG]), 30 ≤ BMI < 35 (group 1 [G1]), 35 ≤ BMI < 40 (group 2 [G2]), and BMI ≥ 40 (group 3 [G3]). The primary outcome measure was the induction-to-delivery interval...
April 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29259030/optical-analysis-of-glioma-fourier-transform-infrared-spectroscopy-reveals-the-idh1-mutation-status
#19
Ortrud Uckermann, Tareq A Juratli, Roberta Galli, Marina Conde, Ralf Wiedemuth, Dietmar Krex, Kathrin D Geiger, Achim Temme, Gabriele Schackert, Edmund Koch, Gerald Steiner, Matthias Kirsch
PURPOSE: Somatic mutations in human cytosolic isocitrate dehydrogenase 1 (IDH1) gene cause profound changes in cell metabolism and are a common feature of gliomas with unprecedented predictive and prognostic impact. Fourier-transform infrared (FT-IR) spectroscopy addresses the molecular composition of cells and tissue and was investigated to deduct the IDH1-mutation status. EXPERIMENTAL DESIGN: We tested the technique on human cell lines that were transduced with IDH1 wild-type or mutated IDH1 and on 34 human glioma samples...
December 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29236165/polyphenol-rich-curry-made-with-mixed-spices-and-vegetables-benefits-glucose-homeostasis-in-chinese-males-polyspice-study-a-dose-response-randomized-controlled-crossover-trial
#20
Sumanto Haldar, Siok Ching Chia, Sze Han Lee, Joseph Lim, Melvin Khee-Shing Leow, Eric Chun Yong Chan, Christiani Jeyakumar Henry
PURPOSE: To investigate acute effects of two doses of a polyphenol-rich curry made with seven different spices and four base vegetables, eaten with white rice, on 24 h glucose response, postprandial insulinemia, triglyceridemia and 24 h urinary total polyphenol excretion (TPE). METHODS: Randomized, controlled, dose-response crossover trial in healthy, Chinese men [n = 20, mean ± standard deviation (SD) age 23.7 ± 2.30 years, BMI 23.0 ± 2.31 kg/m2 ] who consumed test meals matched for calories, macronutrients and total vegetables content, consisting either Dose 0 Control (D0C) or Dose 1 Curry (D1C) or Dose 2 Curry (D2C) meal...
December 13, 2017: European Journal of Nutrition
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