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https://www.readbyqxmd.com/read/28948667/categorical-and-dimensional-perspectives-on-depression-in-elderly-primary-care-patients-results-of-the-agemoode-study
#1
Marie Dorow, Janine Stein, Alexander Pabst, Siegfried Weyerer, Jochen Werle, Wolfgang Maier, Lisa Miebach, Martin Scherer, Anne Stark, Birgitt Wiese, Lilia Moor, Jens-Oliver Bock, Hans-Helmut König, Steffi G Riedel-Heller
An accurate diagnosis is essential for the management of late-life depression in primary care. This study aims to (1) provide information on the agreement on depression diagnoses between general practitioners (GPs), dimensional tools (Geriatric Depression Scale [GDS], Hospital Anxiety and Depression Scale [HADS]) and a categorical tool (Structured Clinical Interview for DSM-IV criteria [SCID]) and (2) identify factors associated with different diagnoses. As part of the multicenter study "Late-life depression in primary care: needs, health care utilization and costs (AgeMooDe)" a sample of 1113 primary care patients aged 75 years and older was assessed...
September 25, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28877196/predicting-active-layer-soil-thickness-using-topographic-variables-at-a-small-watershed-scale
#2
Aidi Li, Xing Tan, Wei Wu, Hongbin Liu, Jie Zhu
Knowledge about the spatial distribution of active-layer (AL) soil thickness is indispensable for ecological modeling, precision agriculture, and land resource management. However, it is difficult to obtain the details on AL soil thickness by using conventional soil survey method. In this research, the objective is to investigate the possibility and accuracy of mapping the spatial distribution of AL soil thickness through random forest (RF) model by using terrain variables at a small watershed scale. A total of 1113 soil samples collected from the slope fields were randomly divided into calibration (770 soil samples) and validation (343 soil samples) sets...
2017: PloS One
https://www.readbyqxmd.com/read/28835393/high-exposure-to-endotoxin-in-farming-is-associated-with-less-new-onset-pollen-sensitisation
#3
Grethe Elholm, Vivi Schlünssen, Gert Doekes, Ioannis Basinas, Anneli Clea Skjelmose Bolund, Charlotte Hjort, Pernille Milvang Grønager, Øyvind Omland, Torben Sigsgaard
OBJECTIVES: Little is known about risk factors for new onset and loss of atopic sensitisation in adulthood. The aim is to examine the longitudinal effect of quantitatively assessed endotoxin exposures on changes in specific allergen sensitisation in young adults. METHODS: The cohort consisted of 1113 young Danish farmers and rural controls, with a mean age of 19 years at baseline. Sensitisation to birch pollen, grass pollen, cat dander and house dust mite was measured by specific IgE levels in serum samples from baseline and at 15 years' follow-up...
August 23, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28760632/effect-of-preoperative-urodynamic-detrusor-underactivity-on-transurethral-surgery-for-benign-prostatic-hyperplasia-a-systematic-review-and-meta-analysis
#4
Myong Kim, Chang Wook Jeong, Seung-June Oh
PURPOSE: To investigate the effect of preoperative urodynamic detrusor underactivity (DUA) on transurethral surgery outcomes for benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: We systematically searched the online PubMed, Embase, and Cochrane Library databases for articles published between January 1989 and June 2017. RESULTS: A total of 10 articles met the eligibility criteria for this systematic review. The eligible studies included a total of 1113 patients with a median number of 73 patients per study (range, 40-382)...
July 28, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28747161/factors-associated-with-perinatal-mortality-among-public-health-deliveries-in-addis-ababa-ethiopia-an-unmatched-case-control-study
#5
Yemisrach Getiye, Mesganaw Fantahun
BACKGROUND: perinatal mortality is the sum of still birth (fetal death) and early neonatal death (ENND) i.e. death of live newborn before the age of 7 completed days. Perinatal mortality accounts three fourth of the deaths of the neonatal period and is one of the major challenges for under-five mortality. Therefore this study was conducted to better understand the common and avoidable factors that affect perinatal mortality in Addis Ababa, Ethiopia. METHODS: An unmatched case control study design using secondary data as a source of information was conducted...
July 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28697188/impact-of-tall-cell-variant-histology-on-predicting-relapse-and-changing-the-management-of-papillary-thyroid-carcinoma-patients
#6
Bengul Gunalp, Kursat Okuyucu, Semra Ince, Aslı Ayan, Engin Alagoz
OBJECTIVE: There has been much discussion recently about the risk category of tall cell variant (TVC) histology and its effects on the management of papillary thyroid carcinoma (PTC). We, therefore, undertook a retrospective study to compare stage-matched risk factors and recurrence rates between classical PTC (cPTC) patients and patients with TCV histology. SUBJECTS AND METHODS: A total of 3128 well-differentiated thyroid carcinoma patients who were treated and followed-up for more than 5 years in our clinic from 1995 to 2016 were included in this study...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28686648/increased-levels-of-soluble-forms-of-e-selectin-and-icam-1-adhesion-molecules-during-human-leptospirosis
#7
Loic Raffray, Claude Giry, Yoga Thirapathi, Anne-Hélène Reboux, Marie-Christine Jaffar-Bandjee, Philippe Gasque
Leptospirosis is a multisystemic zoonotic disease with infiltration of visceral organs by Leptospira. The capacity of the vascular endothelium to grant immune cell recruitment and activation in target organs during the disease course remains poorly characterized. We ascertained the levels of expression of several soluble cell adhesion molecules (CAM) notably expressed by endothelial cells in human leptospirosis. We prospectively enrolled 20 hospitalized patients and compared them to 10 healthy controls. Disease severity was defined by one or more organ failures, or death...
2017: PloS One
https://www.readbyqxmd.com/read/28650917/long-term-changes-in-left-ventricular-mass-echocardiographic-findings-from-a-general-population
#8
Cesare Cuspidi, Fosca Quarti, Raffaella Dell'Oro, Rita Facchetti, Michele Bombelli, Carla Sala, Marijana Tadic, Guido Grassi, Giuseppe Mancia
AIM: We sought to assess the long-term changes in left ventricular (LV) mass in a population-based sample, focusing on new onset, persistence, regression and severity of LV hypertrophy (LVH), as well as on the demographic and clinical variables independently related to this dynamic process. METHODS: A total of 1113 participants with measurable echocardiographic parameters at baseline and after a 10-year follow-up were included in the analysis. Cut points for LVH were derived from current echocardiographic guidelines...
November 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28544337/growth-curves-of-normal-serum-total-ige-levels-throughout-childhood-a-quantile-analysis-in-a-birth-cohort
#9
Chiara Sacco, Serena Perna, Donatella Vicari, Marco Alfò, Carl-Peter Bauer, Ute Hoffman, Johannes Forster, Fred Zepp, Antje Schuster, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi
BACKGROUND: Previous studies of serum total IgE (t-IgE) were not able to discriminate well-enough atopic from non-atopic subjects, that is, with or without serum-specific IgE antibodies to allergens. OBJECTIVES: To model growth curves of the total IgE levels in children without atopic sensitization (hereafter defined as "normal" t-IgE levels) and to test their usefulness in predicting atopic sensitization. METHODS: The German Multicentre Allergy Study (MAS), a birth cohort with 1314 recruited newborns, began in 1990 and examined the participants until age 20 years...
September 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28502135/systemic-lupus-erythmatosus-is-associated-with-disturbed-cytokine-milieu-and-increased-tnf-related-apoptosis-induced-ligand-levels
#10
Amal M Saeed, Mysara M Mogahed
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is cytotoxic to a wide variety of transformed cells, but not to most normal cells. This study measures serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and 10 and soluble TRAIL (sTRAIL) in patients with SLE and assesses their relation to severity of the disease. The study included 70 SLE patients and 20 healthy controls. Patients were diagnosed according to criteria proposed by the American Rheumatism Association for classification of SLE and disease activity was scored using the British Isles Lupus Assessment Group (BILAG-2004)...
June 2016: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/28475591/ketoanalogues-supplementation-decreases-dialysis-and-mortality-risk-in-patients-with-anemic-advanced-chronic-kidney-disease
#11
Che-Hsiung Wu, Ya-Wen Yang, Szu-Chun Hung, Ko-Lin Kuo, Kwan-Dun Wu, Vin-Cent Wu, Tsung-Cheng Hsieh
BACKGROUND: The benefit of alpha-Ketoanalogues (KA) supplementation for chronic kidney disease (CKD) patients that followed low-protein diet (LPD) remains undetermined. METHODS: We extracted longitudinal data for all CKD patients in the Taiwan National Health Insurance from January 1, 2000 through December 31, 2010. A total of 1483 patients with anemic advanced CKD treated with LPD, who started KA supplementation, were enrolled in this study. We analyzed the risks of end stage renal disease and all-cause mortality using Cox proportional hazard models with influential drugs as time-dependent variables...
2017: PloS One
https://www.readbyqxmd.com/read/28456479/age-specific-and-sex-specific-prevalence-of-cerebral-%C3%AE-amyloidosis-tauopathy-and-neurodegeneration-in-cognitively-unimpaired-individuals-aged-50-95-years-a-cross-sectional-study
#12
Clifford R Jack, Heather J Wiste, Stephen D Weigand, Terry M Therneau, David S Knopman, Val Lowe, Prashanthi Vemuri, Michelle M Mielke, Rosebud O Roberts, Mary M Machulda, Matthew L Senjem, Jeffrey L Gunter, Walter A Rocca, Ronald C Petersen
BACKGROUND: A new classification for biomarkers in Alzheimer's disease and cognitive ageing research is based on grouping the markers into three categories: amyloid deposition (A), tauopathy (T), and neurodegeneration or neuronal injury (N). Dichotomising these biomarkers as normal or abnormal results in eight possible profiles. We determined the clinical characteristics and prevalence of each ATN profile in cognitively unimpaired individuals aged 50 years and older. METHODS: All participants were in the Mayo Clinic Study of Aging, a population-based study that uses a medical records linkage system to enumerate all individuals aged 50-89 years in Olmsted County, MN, USA...
June 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28441128/early-career-work-location-of-memorial-university-medical-graduates-why-the-decline-in-rural-practice
#13
Maria Mathews, Dana Ryan, Asoka Samarasena
INTRODUCTION: In a previous study, we found a decline in the proportion of Memorial University of Newfoundland (MUN) medical alumni practising in rural areas, particularly in Newfoundland and Labrador. The current study focused on the work location of recent graduates and examined the predictors of working in rural Canada and in rural Newfoundland and Labrador within the first 15 years following graduation. METHODS: We linked data from graduating class lists and the alumni and postgraduate databases with Scott's Medical Database to create a record of all graduates from 1973 to 2008, including their work location...
2017: Canadian Journal of Rural Medicine
https://www.readbyqxmd.com/read/28413896/congenital-malformations-palliative-care-and-postnatal-redirection-to-more-intensive-treatment-a-review-at-a-swiss-tertiary-center
#14
Ulrich Pfeifer, Deborah Gubler, Eva Bergstraesser, Dirk Bassler
PURPOSE: The so-called lethal malformations pose ethical challenges. Most affected fetuses die before or at birth. Live-born neonates commonly receive palliative care. If the postnatal course is better than expected, redirection towards more treatment may occur. We aimed to analyze this in a Swiss patient cohort. MATERIALS AND METHODS: Over 6 years, fetal malformation was suspected in 1113 cases. We identified patients prenatally assigned to palliative care, assessed pre- and postnatal diagnoses, and outcomes...
April 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28378011/%C3%AE-scores-predict-mild-cognitive-impairment-and-alzheimer-s-disease-conversions-from-nondemented-states
#15
Donald R Royall, Raymond F Palmer
INTRODUCTION: We tested the latent variable "δ" (for "dementia")'s ability to predict conversion to "mild cognitive impairment" (MCI) and Alzheimer's disease (AD). METHODS: An ethnicity equivalent d homolog ("dEQ") was constructed in n = 1113 Mexican- American (MA) and n = 1958 non-Hispanic white (NHW) participants in the Texas Alzheimer's Research and Care Consortium. "Normal Controls" (NC) (n = 1276) and MCI cases (n = 611) were followed annually for up to 6 years [m = 4...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28376340/influence-of-marital-status-on-testosterone-levels-a-ten-year-follow-up-of-1113-men
#16
Stine A Holmboe, Lærke Priskorn, Niels Jørgensen, Niels E Skakkebaek, Allan Linneberg, Anders Juul, Anna-Maria Andersson
Based on a large population of 1113 men aged 30-60 at baseline (mean: 44.1 years, standard deviation: 10.5), we investigated whether intra-individual changes in testosterone (T) and related reproductive hormones during a ten year period were dependent of marital status at baseline and follow-up. The studied men were part of a health survey in Denmark, conducted between 1982 and 1984 with a follow-up examination approximately ten years later. Data on reproductive hormones, measured in serum, and lifestyle and marital status were obtained at both time points...
June 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28374863/genome-wide-study-of-an-elite-rice-pedigree-reveals-a-complex-history-of-genetic-architecture-for-breeding-improvement
#17
Shaoxia Chen, Zechuan Lin, Degui Zhou, Chongrong Wang, Hong Li, Renbo Yu, Hanchao Deng, Xiaoyan Tang, Shaochuan Zhou, Xing Wang Deng, Hang He
Improving breeding has been widely utilized in crop breeding and contributed to yield and quality improvement, yet few researches have been done to analyze genetic architecture underlying breeding improvement comprehensively. Here, we collected genotype and phenotype data of 99 cultivars from the complete pedigree including Huanghuazhan, an elite, high-quality, conventional indica rice that has been grown over 4.5 million hectares in southern China and from which more than 20 excellent cultivars have been derived...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28246015/exome-array-analysis-identifies-variants-in-spocd1-and-btn3a2-that-affect-risk-for-gastric-cancer
#18
MULTICENTER STUDY
Meng Zhu, Caiwang Yan, Chuanli Ren, Xiaodan Huang, Xun Zhu, Haiyong Gu, Meilin Wang, Shouyu Wang, Yong Gao, Yong Ji, Xiaoping Miao, Ming Yang, Jinfei Chen, Jiangbo Du, Tongtong Huang, Yue Jiang, Juncheng Dai, Hongxia Ma, Jianwei Zhou, Zhaoming Wang, Zhibin Hu, Guozhong Ji, Zhengdong Zhang, Hongbing Shen, Yongyong Shi, Guangfu Jin
BACKGROUND & AIMS: Several genetic variants have been associated with gastric cancer risk, although these account for only a fraction of cases of gastric cancer. We aimed to identify low-frequency and other genetic variants that determine gastric cancer susceptibility. METHODS: We performed exome array analysis of DNA in blood samples from 1113 patients with gastric cancer, collected at hospitals from 2006 to 2010 in China, and 1848 individuals without cancer (controls) undergoing physical examinations...
June 2017: Gastroenterology
https://www.readbyqxmd.com/read/28179393/triploid-production-from-interspecific-crosses-of-two-diploid-perennial-helianthus-with-diploid-cultivated-sunflower-helianthus-annuus-l
#19
Zhao Liu, Gerald J Seiler, Thomas J Gulya, Jiuhuan Feng, Khalid Y Rashid, Xiwen Cai, Chao-Chien Jan
Wild Helianthus species are a valuable genetic resource for the improvement of cultivated sunflower. We report the discovery and characterization of a unique high frequency production of triploids when cultivated sunflower was pollinated by specific accessions of diploid Helianthus nuttallii T. & G. and H. maximiliani Schr. Genomic in situ hybridization (GISH) analyses indicated that the triploid F1s had two genomes from the wild pollen sources and one from the cultivated line. Mitotic chromosome analyses indicated that the frequency of triploid progenies from the crosses of cultivated lines × H...
April 3, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28167749/evaluation-of-demands-usage-and-unmet-needs-for-emergency-care-in-yaound%C3%A3-cameroon-a-cross-sectional-study
#20
Young Sun Ro, Sang Do Shin, Joongsik Jeong, Min Jung Kim, Young Hee Jung, Joseph Kamgno, Etoundi Mballa Georges Alain, Bonaventure Hollong
OBJECTIVES: To assess the burden of emergent illnesses and emergency care system usage by Yaoundé residents and to evaluate unmet needs for emergency care and associated barriers. DESIGN: A cross-sectional study using a community-based survey. SETTING: Yaoundé, Cameroon. PARTICIPANTS: All residents living in Yaoundé were selected as the target population to investigate the needs and usage of emergency care in Yaoundé...
February 6, 2017: BMJ Open
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