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https://www.readbyqxmd.com/read/29217955/determinants-of-podoconiosis-a-case-control-study
#1
Berhanu Elfu Feleke
Background: Podoconiosis is a non-filarial swelling of lower extremity endemic in tropical regions, North America and India. The etiology and pathophysiology of the disease remain unknown. The objective of this study was to identify the determinants of Podoconiosis. Methods: Unmatched case control study design was conducted. The sample size was calculated using Epi-info soft ware: 95% CI, 85% power, control to case ratio of 2:1, expected frequency of barefoot among controls 50%, odds ratio of 1...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217027/optic-disc-hemorrhages-in-glaucoma-and-common-clinical-features
#2
Zeynep Kayaarasi Ozturker, Kristen Munro, Neeru Gupta
OBJECTIVE: To analyze optic nerve head stereophotographs for the presence of optic disc hemorrhages, and to describe bleeding patterns and patient characteristics. DESIGN: Retrospective, cross-sectional study. PARTICIPANTS: 1113 optic nerve stereophotograph pairs of 562 consecutive patients. METHODS: Stereophotographs were systematically reviewed for the presence of a disc hemorrhage with careful documentation of optic nerve head features...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29205039/comparison-of-two-static-in-vitro-digestion-methods-for-screening-bioaccessibility-of-carotenoids-in-fruits-vegetables-and-animal-products
#3
Daniele Bobrowski Rodrigues, Chureeporn Chitchumroonchokchai, Lilian Regina Barros Mariutti, Adriana Zerlotti Mercadante, Mark L Failla
In vitro digestion methods are routinely used to assess the bioaccessibility of carotenoids and other dietary lipophilic compounds. Here, we compared the recovery of carotenoids and their efficiency of micellarization in digested fruits, vegetables, egg yolk, salmon and mixed vegetable salad with and without the animal products using the static INFOGEST method (Maniekus et al. Food Funct. 2014, 5, 1113-1124) and the procedure of Failla et al. (Food Funct. 2014, 5, 1101-1112) modified to simulate conditions for the fed state...
December 5, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29172901/correction-to-j-med-food-2017-20-1113-1120-doi-10-1089-jmf-2017-3951
#4
(no author information available yet)
No abstract text is available yet for this article.
November 27, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29168066/changes-in-anxiety-and-depression-symptoms-predict-sexual-risk-behaviors-among-young-men-living-in-dar-es-salaam-tanzania
#5
Lauren M Hill, Nisha C Gottfredson, Lusajo J Kajula, Brian W Pence, Vivian F Go, James Moody, Suzanne Maman
Young men are important targets in HIV prevention in Tanzania and throughout sub-Saharan Africa. Anxiety and depression are common among youth and may be important predictors of HIV risk behaviors; evidence of these relationships in high-risk populations is needed. Using baseline and 1 year follow-up assessments from an HIV prevention trial we assessed the association between changes in symptoms of anxiety and depression and follow-up sexual risk behaviors (condom use and sexual partner concurrency) controlling for baseline sexual risk behaviors among 1113 male members of social groups known as "camps" in Dar es Salaam, Tanzania...
November 22, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29159931/targets-and-teamwork-understanding-differences-in-pediatric-diabetes-centers-treatment-outcomes
#6
Timothy C Skinner, Karin S Lange, Hilary Hoey, Henrik B Mortensen, Henk-Jan Aanstoot, Luis Castaňo, Soren Skovlund, Peter Gf Swift, Fergus J Cameron, Harry R Dorchy, Mark R Palmert, Eero Kaprio, Jean-Jacques Robert, Thomas Danne, Andreas Neu, Shlomit Shalitin, Francesco Chiarelli, Giovanni Chiari, Tatsuhiko Urakami, Pål R Njølstad, Premyslawa K Jarosz-Chobot, Edna F Roche, Cintia G Castro-Correia, Mirjana Kocova, Jan Åman, Eugen Schönle, Timothy G Barrett, Lynda Fisher, Carine E de Beaufort
OBJECTIVE: The reason for center differences in metabolic control of childhood diabetes is still unknown. We sought to determine to what extent the targets, expectations, and goals that diabetes care professionals have for their patients is a determinant of center differences in metabolic outcomes. RESEARCH DESIGN AND METHODS: Children, under the age of 11 with type 1 diabetes and their parents treated at the study centers participated. Clinical, medical, and demographic data were obtained, along with blood sample for centralized assay...
November 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29156358/peer-norms-moderate-the-association-between-mental-health-and-sexual-risk-behaviors-among-young-men-living-in-dar-es-salaam-tanzania
#7
L M Hill, J Moody, N C Gottfredson, L J Kajula, B W Pence, V F Go, S Maman
BACKGROUND: Young men living in Dar es Salaam's informal settlements face environmental stressors that may expose them to multiple determinants of HIV risk including poor mental health and risky sexual behavior norms. We aimed to understand how these co-occurring risk factors not only independently affect men's condom use and sexual partner concurrency, but also how they interact to shape these risk behaviors. METHODS: Participants in the study were male members of 59 social groups known as "camps" in Dar es Salaam, Tanzania...
November 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29126212/hereditary-spastic-paraplegia-type-5-natural-history-biomarkers-and-a-randomized-controlled-trial
#8
Ludger Schöls, Tim W Rattay, Peter Martus, Christoph Meisner, Jonathan Baets, Imma Fischer, Christine Jägle, Matthew J Fraidakis, Andrea Martinuzzi, Jonas Alex Saute, Marina Scarlato, Antonella Antenora, Claudia Stendel, Philip Höflinger, Charles Marques Lourenco, Lisa Abreu, Katrien Smets, Martin Paucar, Tine Deconinck, Dana M Bis, Sarah Wiethoff, Peter Bauer, Alessia Arnoldi, Wilson Marques, Laura Bannach Jardim, Stefan Hauser, Chiara Criscuolo, Alessandro Filla, Stephan Züchner, Maria Teresa Bassi, Thomas Klopstock, Peter De Jonghe, Ingemar Björkhem, Rebecca Schüle
Spastic paraplegia type 5 (SPG5) is a rare subtype of hereditary spastic paraplegia, a highly heterogeneous group of neurodegenerative disorders defined by progressive neurodegeneration of the corticospinal tract motor neurons. SPG5 is caused by recessive mutations in the gene CYP7B1 encoding oxysterol-7α-hydroxylase. This enzyme is involved in the degradation of cholesterol into primary bile acids. CYP7B1 deficiency has been shown to lead to accumulation of neurotoxic oxysterols. In this multicentre study, we have performed detailed clinical and biochemical analysis in 34 genetically confirmed SPG5 cases from 28 families, studied dose-dependent neurotoxicity of oxysterols in human cortical neurons and performed a randomized placebo-controlled double blind interventional trial targeting oxysterol accumulation in serum of SPG5 patients...
November 6, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29121502/the-prognostic-role-of-epigenetic-dysregulation-in-bladder-cancer-a-systematic-review
#9
REVIEW
David Casadevall, Anaïs Yacine Kilian, Joaquim Bellmunt
BACKGROUND: Despite adequate treatment and follow-up, around one fifth of patients with localized bladder cancer will present with disease progression. Adequate prognostic biomarkers are lacking to define patients who are at risk. Mutations in chromatin remodeling genes are more frequently found in bladder cancer than in any other solid tumor. However, the prognostic relevance of epigenetic dysregulation has not been established and may offer an opportunity for biomarker discovery. METHODS: Looking for prognostic epigenetic factors, we performed a comprehensive PubMed search using keywords such as "bladder cancer", "chromatin remodeling", "gene methylation" and "epigenetics"...
November 6, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29105320/impact-of-hepatitis-c-virus-hcv-antiviral-treatment-on-the-need-for-liver-transplantation-lt
#10
Esteban Sáez-González, Carmen Vinaixa, Fernando San Juan, Vanesa Hontangas, Salvador Benlloch, Victoria Aguilera, Angel Rubín, María García, Martín Prieto, Rafa López-Andujar, Marina Berenguer
BACKGROUND: Therapies for hepatitis C virus (HCV) infection have revolutionized the treatment of patients with chronic HCV infection. The effect of these therapies on the epidemiology of liver transplantation (LT) has yet to be elucidated. AIM: To establish whether the indications for LT have changed as a result of the introduction of new therapies for HCV. MATERIALS AND METHODS: We conducted a retrospective study based on a prospectively maintained registry of patients who undergo LT at La Fe Hospital in Valencia from 1997 to 2016...
November 4, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29094339/prospective-study-on-long-term-outcome-after-abdominal-surgery
#11
E D Brynjarsdottir, M I Sigurdsson, E Sigmundsdottir, P H Möller, G H Sigurdsson
BACKGROUND: Complications following major abdominal surgery are common and an important cause of morbidity and mortality. The aim of this study was to describe 1-year mortality and identify factors that influence adverse outcomes after abdominal surgery. METHODS: This prospective observational cohort study was performed in Landspitali University Hospital and included all adult patients undergoing abdominal surgery requiring > 24-h hospital admission over 13 months...
November 1, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29093151/effect-of-anticitrullinated-protein-antibody-status-on-response-to-abatacept-or-antitumor-necrosis-factor-%C3%AE-therapy-in-patients-with-rheumatoid-arthritis-a-us-national-observational-study
#12
Leslie R Harrold, Heather J Litman, Sean E Connolly, Sheila Kelly, Winnie Hua, Evo Alemao, Lisa Rosenblatt, Sabrina Rebello, Joel M Kremer
OBJECTIVE: Assess whether baseline anticyclic citrullinated peptide antibodies (anti-CCP) status is associated with treatment response in patients with rheumatoid arthritis (RA) initiating abatacept (ABA) or a tumor necrosis factor-α inhibitor (TNFi). METHODS: Using the Corrona RA registry, patients were identified who initiated ABA or a TNFi (June 2004-January 2015), had a followup visit 6 months (± 3 mos) after initiation, and anti-CCP measured at or prior to initiation...
November 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29057819/a-national-dietary-assessment-reference-database-ndard-for-the-dutch-population-rationale-behind-the-design
#13
Elske M Brouwer-Brolsma, Martinette T Streppel, Linde van Lee, Anouk Geelen, Diewertje Sluik, Anne M van de Wiel, Jeanne H M de Vries, Pieter van 't Veer, Edith J M Feskens
The development of reliable Food Frequency Questionnaires (FFQs) requires detailed information about the level and variation of dietary intake of the target population. However, these data are often limited. To facilitate the development of new high quality FFQs and validation of existing FFQs, we developed a comprehensive National Dietary Assessment Reference Database (NDARD) detailing information about the level and variation in dietary intake of people 20-70 years old in the general Dutch population. This paper describes the methods and characteristics of the population included in the NDARD database...
October 18, 2017: Nutrients
https://www.readbyqxmd.com/read/29049073/postoperative-outcomes-in-obstructive-sleep-apnea-patients-undergoing-cardiac-surgery-a-systematic-review-and-meta-analysis-of-comparative-studies
#14
Mahesh Nagappa, George Ho, Jayadeep Patra, Jean Wong, Mandeep Singh, Roop Kaw, Davy Cheng, Frances Chung
BACKGROUND: Obstructive sleep apnea (OSA) is a common comorbidity in patients undergoing cardiac surgery and may predispose patients to postoperative complications. The purpose of this meta-analysis is to determine the evidence of postoperative complications associated with OSA patients undergoing cardiac surgery. METHODS: A literature search of Cochrane Database of Systematic Reviews, Medline, Medline In-process, Web of Science, Scopus, EMBASE, Cochrane Central Register of Controlled Trials, and CINAHL until October 2016 was performed...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28948667/categorical-and-dimensional-perspectives-on-depression-in-elderly-primary-care-patients-results-of-the-agemoode-study
#15
Marie Dorow, Janine Stein, Alexander Pabst, Siegfried Weyerer, Jochen Werle, Wolfgang Maier, Lisa Miebach, Martin Scherer, Anne Stark, Birgitt Wiese, Lilia Moor, Jens-Oliver Bock, Hans-Helmut König, Steffi G Riedel-Heller
An accurate diagnosis is essential for the management of late-life depression in primary care. This study aims to (1) provide information on the agreement on depression diagnoses between general practitioners (GPs), dimensional tools (Geriatric Depression Scale [GDS], Hospital Anxiety and Depression Scale [HADS]) and a categorical tool (Structured Clinical Interview for DSM-IV criteria [SCID]) and (2) identify factors associated with different diagnoses. As part of the multicenter study "Late-life depression in primary care: needs, health care utilization and costs (AgeMooDe)" a sample of 1113 primary care patients aged 75 years and older was assessed...
September 25, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28877196/predicting-active-layer-soil-thickness-using-topographic-variables-at-a-small-watershed-scale
#16
Aidi Li, Xing Tan, Wei Wu, Hongbin Liu, Jie Zhu
Knowledge about the spatial distribution of active-layer (AL) soil thickness is indispensable for ecological modeling, precision agriculture, and land resource management. However, it is difficult to obtain the details on AL soil thickness by using conventional soil survey method. In this research, the objective is to investigate the possibility and accuracy of mapping the spatial distribution of AL soil thickness through random forest (RF) model by using terrain variables at a small watershed scale. A total of 1113 soil samples collected from the slope fields were randomly divided into calibration (770 soil samples) and validation (343 soil samples) sets...
2017: PloS One
https://www.readbyqxmd.com/read/28835393/high-exposure-to-endotoxin-in-farming-is-associated-with-less-new-onset-pollen-sensitisation
#17
Grethe Elholm, Vivi Schlünssen, Gert Doekes, Ioannis Basinas, Anneli Clea Skjelmose Bolund, Charlotte Hjort, Pernille Milvang Grønager, Øyvind Omland, Torben Sigsgaard
OBJECTIVES: Little is known about risk factors for new onset and loss of atopic sensitisation in adulthood. The aim is to examine the longitudinal effect of quantitatively assessed endotoxin exposures on changes in specific allergen sensitisation in young adults. METHODS: The cohort consisted of 1113 young Danish farmers and rural controls, with a mean age of 19 years at baseline. Sensitisation to birch pollen, grass pollen, cat dander and house dust mite was measured by specific IgE levels in serum samples from baseline and at 15 years' follow-up...
August 23, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28760632/effect-of-preoperative-urodynamic-detrusor-underactivity-on%C3%A2-transurethral-surgery-for-benign-prostatic-hyperplasia-a%C3%A2-systematic-review-and-meta-analysis
#18
Myong Kim, Chang Wook Jeong, Seung-June Oh
PURPOSE: We investigated the effect of preoperative urodynamic detrusor underactivity on the transurethral surgery outcomes of benign prostatic hyperplasia. MATERIALS AND METHODS: We systematically searched the online PubMed®, Embase® and Cochrane Library databases for articles published between January 1989 and June 2017. RESULTS: A total of 10 articles met the eligibility criteria for this systematic review. The eligible studies included a total of 1,113 patients with a median of 73 per study (range 40 to 382)...
July 29, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28747161/factors-associated-with-perinatal-mortality-among-public-health-deliveries-in-addis-ababa-ethiopia-an-unmatched-case-control-study
#19
Yemisrach Getiye, Mesganaw Fantahun
BACKGROUND: perinatal mortality is the sum of still birth (fetal death) and early neonatal death (ENND) i.e. death of live newborn before the age of 7 completed days. Perinatal mortality accounts three fourth of the deaths of the neonatal period and is one of the major challenges for under-five mortality. Therefore this study was conducted to better understand the common and avoidable factors that affect perinatal mortality in Addis Ababa, Ethiopia. METHODS: An unmatched case control study design using secondary data as a source of information was conducted...
July 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28697188/impact-of-tall-cell-variant-histology-on-predicting-relapse-and-changing-the-management-of-papillary-thyroid-carcinoma-patients
#20
Bengul Gunalp, Kursat Okuyucu, Semra Ince, Aslı Ayan, Engin Alagoz
OBJECTIVE: There has been much discussion recently about the risk category of tall cell variant (TVC) histology and its effects on the management of papillary thyroid carcinoma (PTC). We, therefore, undertook a retrospective study to compare stage-matched risk factors and recurrence rates between classical PTC (cPTC) patients and patients with TCV histology. SUBJECTS AND METHODS: A total of 3128 well-differentiated thyroid carcinoma patients who were treated and followed-up for more than 5 years in our clinic from 1995 to 2016 were included in this study...
May 2017: Hellenic Journal of Nuclear Medicine
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