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https://www.readbyqxmd.com/read/29468257/aurora-kinase-b-regulates-axonal-outgrowth-and-regeneration-in-the-spinal-motor-neurons-of-developing-zebrafish
#1
Serene S L Gwee, Rowan A W Radford, Sharron Chow, Monisha D Syal, Marco Morsch, Isabel Formella, Albert Lee, Emily K Don, Andrew P Badrock, Nicholas J Cole, Adrian K West, Steve N S Cheung, Roger S Chung
Aurora kinase B (AurkB) is a serine/threonine protein kinase with a well-characterised role in orchestrating cell division and cytokinesis, and is prominently expressed in healthy proliferating and cancerous cells. However, the role of AurkB in differentiated and non-dividing cells has not been extensively explored. Previously, we have described a significant upregulation of AurkB expression in cultured cortical neurons following an experimental axonal transection. This is somewhat surprising, as AurkB expression is generally associated only with dividing cells Frangini et al...
February 21, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29429815/long-term-immunogenicity-of-an-initial-booster-dose-of-an-inactivated-vero-cell-culture-derived-japanese-encephalitis-vaccine-je-vc-and-the-safety-and-immunogenicity-of-a-second-je-vc-booster-dose-in-children-previously-vaccinated-with-an-inactivated-mouse
#2
Ki Wook Yun, Hoan Jong Lee, Ji Young Park, Hye-Kyung Cho, Yae-Jean Kim, Kyung-Hyo Kim, Nam Hee Kim, Young Jin Hong, Dong Ho Kim, Hwang Min Kim, Sung-Ho Cha
BACKGROUND: This study was performed with the aim of determining the long-term immunogenicity of an inactivated, Vero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC) and an inactivated, mouse brain-derived JE vaccine (JE-MB) after the 1st booster dose at 2 years of age, as well as the safety and immunogenicity of the 2nd booster dose of JE-VC at 6 years of age, in children primed and given a 1st booster dose of either JE-VC or JE-MB. METHOD: In this multicenter, open-label clinical trial, the study population consisted of healthy Korean children (aged 6 years) who participated in the previous JE vaccine trial...
February 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29413946/trichomonas-vaginalis-cathepsin-d-like-aspartic-proteinase-tv-catd-is-positively-regulated-by-glucose-and-degrades-human-hemoglobin
#3
Maria Inocente Mancilla-Olea, Jaime Ortega-López, Elisa E Figueroa-Angulo, Leticia Avila-González, Rosa Elena Cárdenas-Guerra, Jesús F T Miranda-Ozuna, Arturo González-Robles, Mar Saraí Hernández-García, Lizbeth Sánchez-Ayala, Rossana Arroyo
Trichomonas vaginalis genome encodes ∼440 proteases, six of which are aspartic proteases (APs). However, only one belongs to a clan AA (EC 3.4.23.5), family A1 (pepsin A), cathepsin D-like protease. This AP is encoded by an 1113-bp gene (tv-catd), which translates into a 370-aa residues zymogen of 40.7-kDa and a theoretical pI of 4.6, generating a ∼35 kDa active enzyme after maturation (Tv-CatD). The goal of this study was to identify and analyze the effect of glucose on the expression of Tv-CatD at the transcript and protein levels, subcellular localization, and proteolytic activity...
January 29, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29413941/effect-of-diclofenac-on-the-production-of-volatile-fatty-acids-from-anaerobic-fermentation-of-waste-activated-sludge
#4
Jiawei Hu, Jianwei Zhao, Dongbo Wang, Xiaoming Li, Dan Zhang, Qiuxiang Xu, Lai Peng, Qi Yang, Guangming Zeng
In this study, the impact of diclofenac (DCF), an antiinflammatory drug being extensively used in human health care and veterinary treatment, on the production of volatile fatty acids (VFAs) from anaerobic fermentation of waste activated sludge (WAS) was investigated for the first time. Experimental results showed that when DCF concentration increased from 2.5 to 25 mg/kg total suspended solid (TSS), the maximum production of VFAs increased from 599 to 1113 mg COD/L, but further increase of DCF to 47...
January 13, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29410275/the-comprehensive-expression-analysis-of-the-g-protein-coupled-receptor-from-penaeus-monodon-indicating-it-participates-in-innate-immunity-and-anti-ammonia-nitrogen-stress
#5
Dandan Zhu, Lishi Yang, Huang Jianhua, Zhou Falin, Yang Qibin, Jiang Song, Shigui Jiang
The G protein-coupled receptors (GPCRs) composed a superfamily that played an important role in physiological processes of crustaceans, with multiple functions such as growth and development, acting as a defense against stimulations from external factors. In this paper, one kind of GPCRs were identified from Penaeus monodon, called PmGPCR, included an open reading frame (ORF) of 1113 bp. Bioinformatic analysis showed that PmGPCR protein had the typical structure of seven transmembrane domains (7TM), especially the special Asp-Arg-Try motif (DRY motif) between the third transmembrane structures (TM3) and the second intracellular loops (IL-2) which can prove that PmGPCR belongs to the rhodopsin-like family...
February 1, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29406579/intraoperative-interventions-for-preventing-surgical-site-infection-an-overview-of-cochrane-reviews
#6
REVIEW
Zhenmi Liu, Jo C Dumville, Gill Norman, Maggie J Westby, Jane Blazeby, Emma McFarlane, Nicky J Welton, Louise O'Connor, Julie Cawthorne, Ryan P George, Emma J Crosbie, Amber D Rithalia, Hung-Yuan Cheng
BACKGROUND: Surgical site infection (SSI) rates vary from 1% to 5% in the month following surgery. Due to the large number of surgical procedures conducted annually, the costs of these SSIs can be considerable in financial and social terms. Many interventions are used with the aim of reducing the risk of SSI in people undergoing surgery. These interventions can be broadly delivered at three stages: preoperatively, intraoperatively and postoperatively. The intraoperative interventions are largely focused on decontamination of skin using soap and antiseptics; the use of barriers to prevent movement of micro-organisms into incisions; and optimising the patient's own bodily functions to promote best recovery...
February 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29388061/clinical-impact-of-pi3k-braf-mutations-in-ras-wild-metastatic-colorectal-cancer-meta-analysis-results
#7
Amr Mohamed, Brandon Twardy, Nadine AbdAllah, Alaa Akhras, Hibah Ismail, Magdi Zordok, Kelly Schrapp, Taraq Attumi, Anteneh Tesfaye, Bassel El-Rayes
BACKGROUND: Understanding the molecular mechanisms of colorectal cancer has evolved during the last decade ushering the era of personalized medicine. Alteration of BRAF and PI3K is common in colorectal cancer, and can affect several signaling pathways including EGFR (epidermal growth factor receptor). The aim of this meta-analysis is to evaluate the clinical role of PI3K and BRAF mutations in patients with KRAS wild-type metastatic colorectal cancer (MCRC) receiving an EGFR monoclonal antibody (anti-EGFR) inhibitor as first-line therapy...
February 1, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29372842/decreased-daytime-light-intensity-at-nonwindow-hospital-beds-comparisons-with-light-intensity-at-window-hospital-beds-and-light-exposure-in-nonhospitalized-elderly-individuals
#8
Junko Iwamoto, Kenji Obayashi, Miwa Kobayashi, Toshimichi Kotsuji, Rie Matsui, Kyoko Ito, Osamu Yoshida, Norio Kurumatani, Keigo Saeki
Light is crucial for the synchronization of internal biological rhythms with environmental rhythms. Hospitalization causes a range of unfavorable medical conditions, including delirium, sleep disturbances, depressed mood, and increased fall, especially in elderly people. The hospital room environment contributes significantly to patients' circadian physiology and behavior; however, few studies have evaluated light intensity in hospital settings. In this study, bedside light intensity during the daytime (6:00-21:00) was measured at 1-min intervals using a light meter on 4869 bed-days at the Inabe General Hospital in Mie, Japan (latitude 35°N), for approximately 1 month in each season...
January 26, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29316054/influence-of-body-mass-index-on-induction-of-labor-a-historical-cohort-study
#9
Ulf Dammer, Roswitha Bogner, Christel Weiss, Florian Faschingbauer, Jutta Pretscher, Matthias W Beckmann, Marc Sütterlin, Sven Kehl
AIM: We aimed to determine the influence of body mass index (BMI) on induction of labor. METHODS: In this historical multicenter cohort study, 2122 labor inductions were analyzed. Women were divided into four groups according to their body mass index (BMI): BMI < 30 (normal group [NG]), 30 ≤ BMI < 35 (group 1 [G1]), 35 ≤ BMI < 40 (group 2 [G2]), and BMI ≥ 40 (group 3 [G3]). The primary outcome measure was the induction-to-delivery interval...
January 8, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29259030/optical-analysis-of-glioma-fourier-transform-infrared-spectroscopy-reveals-the-idh1-mutation-status
#10
Ortrud Uckermann, Tareq A Juratli, Roberta Galli, Marina Conde, Ralf Wiedemuth, Dietmar Krex, Kathrin D Geiger, Achim Temme, Gabriele Schackert, Edmund Koch, Gerald Steiner, Matthias Kirsch
PURPOSE: Somatic mutations in human cytosolic isocitrate dehydrogenase 1 (IDH1) gene cause profound changes in cell metabolism and are a common feature of gliomas with unprecedented predictive and prognostic impact. Fourier-transform infrared (FT-IR) spectroscopy addresses the molecular composition of cells and tissue and was investigated to deduct the IDH1-mutation status. EXPERIMENTAL DESIGN: We tested the technique on human cell lines that were transduced with IDH1 wild-type or mutated IDH1 and on 34 human glioma samples...
December 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29236165/polyphenol-rich-curry-made-with-mixed-spices-and-vegetables-benefits-glucose-homeostasis-in-chinese-males-polyspice-study-a-dose-response-randomized-controlled-crossover-trial
#11
Sumanto Haldar, Siok Ching Chia, Sze Han Lee, Joseph Lim, Melvin Khee-Shing Leow, Eric Chun Yong Chan, Christiani Jeyakumar Henry
PURPOSE: To investigate acute effects of two doses of a polyphenol-rich curry made with seven different spices and four base vegetables, eaten with white rice, on 24 h glucose response, postprandial insulinemia, triglyceridemia and 24 h urinary total polyphenol excretion (TPE). METHODS: Randomized, controlled, dose-response crossover trial in healthy, Chinese men [n = 20, mean ± standard deviation (SD) age 23.7 ± 2.30 years, BMI 23.0 ± 2.31 kg/m2] who consumed test meals matched for calories, macronutrients and total vegetables content, consisting either Dose 0 Control (D0C) or Dose 1 Curry (D1C) or Dose 2 Curry (D2C) meal...
December 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29217955/determinants-of-podoconiosis-a-case-control-study
#12
Berhanu Elfu Feleke
Background: Podoconiosis is a non-filarial swelling of lower extremity endemic in tropical regions, North America and India. The etiology and pathophysiology of the disease remain unknown. The objective of this study was to identify the determinants of Podoconiosis. Methods: Unmatched case control study design was conducted. The sample size was calculated using Epi-info soft ware: 95% CI, 85% power, control to case ratio of 2:1, expected frequency of barefoot among controls 50%, odds ratio of 1...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217027/optic-disc-hemorrhages-in-glaucoma-and-common-clinical-features
#13
Zeynep Kayaarasi Ozturker, Kristen Munro, Neeru Gupta
OBJECTIVE: To analyze optic nerve head stereophotographs for the presence of optic disc hemorrhages, and to describe bleeding patterns and patient characteristics. DESIGN: Retrospective, cross-sectional study. PARTICIPANTS: 1113 optic nerve stereophotograph pairs of 562 consecutive patients. METHODS: Stereophotographs were systematically reviewed for the presence of a disc hemorrhage with careful documentation of optic nerve head features...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29205039/comparison-of-two-static-in-vitro-digestion-methods-for-screening-bioaccessibility-of-carotenoids-in-fruits-vegetables-and-animal-products
#14
Daniele Bobrowski Rodrigues, Chureeporn Chitchumroonchokchai, Lilian Regina Barros Mariutti, Adriana Zerlotti Mercadante, Mark L Failla
In vitro digestion methods are routinely used to assess the bioaccessibility of carotenoids and other dietary lipophilic compounds. Here, we compared the recovery of carotenoids and their efficiency of micellarization in digested fruits, vegetables, egg yolk, salmon and mixed vegetable salad with and without the animal products using the static INFOGEST method (Maniekus et al. Food Funct. 2014, 5, 1113-1124) and the procedure of Failla et al. (Food Funct. 2014, 5, 1101-1112) modified to simulate conditions for the fed state...
December 5, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29172901/correction-to-j-med-food-2017-20-1113-1120-doi-10-1089-jmf-2017-3951
#15
(no author information available yet)
No abstract text is available yet for this article.
November 27, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29168066/changes-in-anxiety-and-depression-symptoms-predict-sexual-risk-behaviors-among-young-men-living-in-dar-es-salaam-tanzania
#16
Lauren M Hill, Nisha C Gottfredson, Lusajo J Kajula, Brian W Pence, Vivian F Go, James Moody, Suzanne Maman
Young men are important targets in HIV prevention in Tanzania and throughout sub-Saharan Africa. Anxiety and depression are common among youth and may be important predictors of HIV risk behaviors; evidence of these relationships in high-risk populations is needed. Using baseline and 1 year follow-up assessments from an HIV prevention trial we assessed the association between changes in symptoms of anxiety and depression and follow-up sexual risk behaviors (condom use and sexual partner concurrency) controlling for baseline sexual risk behaviors among 1113 male members of social groups known as "camps" in Dar es Salaam, Tanzania...
November 22, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29159931/targets-and-teamwork-understanding-differences-in-pediatric-diabetes-centers-treatment-outcomes
#17
Timothy C Skinner, Karin S Lange, Hilary Hoey, Henrik B Mortensen, Henk-Jan Aanstoot, Luis Castaňo, Soren Skovlund, Peter Gf Swift, Fergus J Cameron, Harry R Dorchy, Mark R Palmert, Eero Kaprio, Jean-Jacques Robert, Thomas Danne, Andreas Neu, Shlomit Shalitin, Francesco Chiarelli, Giovanni Chiari, Tatsuhiko Urakami, Pål R Njølstad, Premyslawa K Jarosz-Chobot, Edna F Roche, Cintia G Castro-Correia, Mirjana Kocova, Jan Åman, Eugen Schönle, Timothy G Barrett, Lynda Fisher, Carine E de Beaufort
OBJECTIVE: The reason for center differences in metabolic control of childhood diabetes is still unknown. We sought to determine to what extent the targets, expectations, and goals that diabetes care professionals have for their patients is a determinant of center differences in metabolic outcomes. RESEARCH DESIGN AND METHODS: Children, under the age of 11 with type 1 diabetes and their parents treated at the study centers participated. Clinical, medical, and demographic data were obtained, along with blood sample for centralized assay...
November 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29156358/peer-norms-moderate-the-association-between-mental-health-and-sexual-risk-behaviors-among-young-men-living-in-dar-es-salaam-tanzania
#18
L M Hill, J Moody, N C Gottfredson, L J Kajula, B W Pence, V F Go, S Maman
BACKGROUND: Young men living in Dar es Salaam's informal settlements face environmental stressors that may expose them to multiple determinants of HIV risk including poor mental health and risky sexual behavior norms. We aimed to understand how these co-occurring risk factors not only independently affect men's condom use and sexual partner concurrency, but also how they interact to shape these risk behaviors. METHODS: Participants in the study were male members of 59 social groups known as "camps" in Dar es Salaam, Tanzania...
November 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29126212/hereditary-spastic-paraplegia-type-5-natural-history-biomarkers-and-a-randomized-controlled-trial
#19
Ludger Schöls, Tim W Rattay, Peter Martus, Christoph Meisner, Jonathan Baets, Imma Fischer, Christine Jägle, Matthew J Fraidakis, Andrea Martinuzzi, Jonas Alex Saute, Marina Scarlato, Antonella Antenora, Claudia Stendel, Philip Höflinger, Charles Marques Lourenco, Lisa Abreu, Katrien Smets, Martin Paucar, Tine Deconinck, Dana M Bis, Sarah Wiethoff, Peter Bauer, Alessia Arnoldi, Wilson Marques, Laura Bannach Jardim, Stefan Hauser, Chiara Criscuolo, Alessandro Filla, Stephan Züchner, Maria Teresa Bassi, Thomas Klopstock, Peter De Jonghe, Ingemar Björkhem, Rebecca Schüle
Spastic paraplegia type 5 (SPG5) is a rare subtype of hereditary spastic paraplegia, a highly heterogeneous group of neurodegenerative disorders defined by progressive neurodegeneration of the corticospinal tract motor neurons. SPG5 is caused by recessive mutations in the gene CYP7B1 encoding oxysterol-7α-hydroxylase. This enzyme is involved in the degradation of cholesterol into primary bile acids. CYP7B1 deficiency has been shown to lead to accumulation of neurotoxic oxysterols. In this multicentre study, we have performed detailed clinical and biochemical analysis in 34 genetically confirmed SPG5 cases from 28 families, studied dose-dependent neurotoxicity of oxysterols in human cortical neurons and performed a randomized placebo-controlled double blind interventional trial targeting oxysterol accumulation in serum of SPG5 patients...
November 6, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29121502/the-prognostic-role-of-epigenetic-dysregulation-in-bladder-cancer-a-systematic-review
#20
REVIEW
David Casadevall, Anaïs Yacine Kilian, Joaquim Bellmunt
BACKGROUND: Despite adequate treatment and follow-up, around one fifth of patients with localized bladder cancer will present with disease progression. Adequate prognostic biomarkers are lacking to define patients who are at risk. Mutations in chromatin remodeling genes are more frequently found in bladder cancer than in any other solid tumor. However, the prognostic relevance of epigenetic dysregulation has not been established and may offer an opportunity for biomarker discovery. METHODS: Looking for prognostic epigenetic factors, we performed a comprehensive PubMed search using keywords such as "bladder cancer", "chromatin remodeling", "gene methylation" and "epigenetics"...
November 6, 2017: Cancer Treatment Reviews
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