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https://www.readbyqxmd.com/read/28445864/tumor-antigen-glycosaminoglycan-modification-regulates-antibody-drug-conjugate-delivery-and-cytotoxicity
#1
Helena C Christianson, Julien A Menard, Vineesh Indira Chandran, Erika Bourseau-Guilmain, Dmitry Shevela, Jon Lidfeldt, Ann-Sofie Månsson, Silvia Pastorekova, Johannes Messinger, Mattias Belting
Aggressive cancers are characterized by hypoxia, which is a key driver of tumor development and treatment resistance. Proteins specifically expressed in the hypoxic tumor microenvironment thus represent interesting candidates for targeted drug delivery strategies. Carbonic anhydrase (CAIX) has been identified as an attractive treatment target as it is highly hypoxia specific and expressed at the cell-surface to promote cancer cell aggressiveness. Here, we find that cancer cell internalization of CAIX is negatively regulated by post-translational modification with chondroitin or heparan sulfate glycosaminoglycan chains...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28444564/response-to-lead-pollution-mycorrhizal-pinus-sylvestris-forms-the-biomineral-pyromorphite-in-roots-and-needles
#2
Maria L Bizo, Sandor Nietzsche, Ulrich Mansfeld, Falko Langenhorst, Juraj Majzlan, Jörg Göttlicher, Alexandru Ozunu, Steffi Formann, Katrin Krause, Erika Kothe
The development of mycorrhized pine seedlings grown in the presence of lead was assessed in order to investigate how higher plants can tolerate lead pollution in the environment. Examination with scanning electron microscopy (SEM) revealed that Pb uptake was prominent in the roots, while a smaller amount was found in pine needles, which requires symplastic uptake and root-to-shoot transfer. Lead was concentrated in nanocrystalline aggregates attached to the cell wall and, according to elemental microanalyses, is associated with phosphorus and chlorine...
April 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28444481/peer-victimization-and-suicidal-thoughts-and-behaviors-in-depressed-adolescents
#3
Jeremy G Stewart, Linda Valeri, Erika C Esposito, Randy P Auerbach
Suicide is a leading cause of death among youth worldwide, and depressed adolescents are at a significantly elevated risk to report suicidal ideation, planning, and attempts. Peer victimization is a robust predictor of adolescent suicidal thoughts and behaviors (STBs), but little research has focused on why bullying leads to suicidal thoughts and behaviors. To address this empirical gap, we recruited 340 (246 female) depressed adolescents ages 13-19 (M = 15.59, SD = 1.41) within 48 h of admission for acute psychiatric treatment...
April 25, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28444135/prevalence-and-correlates-of-olfactory-dysfunction-in-old-age-a-population-based-study
#4
Janina Seubert, Erika J Laukka, Debora Rizzuto, Thomas Hummel, Laura Fratiglioni, Lars Bäckman, Maria Larsson
Background: Olfactory dysfunction (OD) in old age is associated with poor health outcomes. Interrelationships among different correlates of OD can offer insights into the underlying mechanisms, but to date remain understudied. Methods: Odor identification performance and self-reported olfactory functioning were studied in 2,234 people aged 60-90 years, who were free of neurodegenerative disease and enrolled in the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) study, Stockholm, Sweden...
April 21, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28443984/antifungal-activity-of-caspofungin-in-experimental-infective-endocarditis-caused-by-candida-albicans
#5
Gerardo Becerra Victorio, Lorena Michele Brennan Bourdon, Leonel García Benavides, Selene G Huerta-Olvera, Arturo Plascencia, José Villanueva, Erika Martinez-Lopez, Iván Isidro Hernández-Cañaveral
BACKGROUND: Infective endocarditis is a disease characterised by heart valve lesions, which exhibit extracellular matrix proteins that act as a physical barrier to prevent the passage of antimicrobial agents. The genus Candida has acquired clinical importance given that it is increasingly being isolated from cases of nosocomial infections. OBJECTIVE: To evaluate the activity of caspofungin compared to that of liposomal amphotericin B against Candida albicans in experimental infective endocarditis...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28443975/breastfeeding-assessment-instruments-and-their-use-in-clinical-practice
#6
Bárbara Tideman Sartorio, Kelly Pereira Coca, Karla Oliveira Marcacine, Érika de Sá Vieira Abuchaim, Ana Cristina Freitas de Vilhena Abrão
Objectives: To identify breastfeeding assessment tools, their application in clinical practice, and their validation and cross-cultural adaptation. Method: This is an integrative review of literature obtained from six databases and an online library, conducted from August 2014 to December 2015, without a temporal delimitation. Results: We identified 19 assessment tools, of which 12 were validated and five were cross-culturally adapted. In terms of adaptation, the tools were used to assess the risk of early weaning (BAPT) and the perception/behaviour of mothers during nursing (BSES-SF and IIFAS)...
April 20, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28443132/disease-resistance-and-the-definition-of-genetic-enhancement
#7
Derek So, Erika Kleiderman, Seydina B Touré, Yann Joly
Recent gene editing experiments carried out in human embryos have raised the question of whether interventions like the introduction of a CCR5-Δ32 deletion, which could provide heritable resistance to HIV infection, ought to be considered enhancements. Many authors have used the term "enhancement" in different ways, some based on patients' biomedical outcomes and others on their social context. These classifications are often considered overly imprecise. Nevertheless, the concept of "enhancement" could affect the ways in which these applications are regulated in different jurisdictions, the availability of coverage by insurers or public health care, and the force of public opinion in shaping future policy on gene editing...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28442824/lessons-in-care-insights-into-recent-changes-in-the-american-diabetes-association-s-clinical-practice-recommendations
#8
Erika Gebel Berg
No abstract text is available yet for this article.
April 2017: Clinical Diabetes: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/28442663/histochemical-assessment-for-osteoblastic-activity-coupled-with-dysfunctional-osteoclasts-in-c-src-deficient-mice
#9
Hisashi Toray, Tomoka Hasegawa, Naoko Sakagami, Erika Tsuchiya, Ai Kudo, Shen Zhao, Yasuhito Moritani, Miki Abe, Taiji Yoshida, Tomomaya Yamamoto, Tsuneyuki Yamamoto, Kimimitsu Oda, Nobuyuki Udagawa, Paulo Henrique Luiz de Freitas, Minqi Li
Since osteoblastic activities are believed to be coupled with osteoclasts, we have attempted to histologically verify which of the distinct cellular circumstances, the presence of osteoclasts themselves or bone resorption by osteoclasts, is essential for coupled osteoblastic activity, by examining c-fos(-/-) or c-src(-/-) mice. Osteopetrotic c-fos deficient (c-fos(-/-)) mice have no osteoclasts, while c-src deficient (c-src(-/-)) mice, another osteopetrotic model, develop dysfunctional osteoclasts due to a lack of ruffled borders...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28442450/implementing-an-internet-delivered-skin-cancer-genetic-testing-intervention-to-improve-sun-protection-behavior-in-a-diverse-population-protocol-for-a-randomized-controlled-trial
#10
Jennifer L Hay, Marianne Berwick, Kate Zielaskowski, Kirsten Am White, Vivian M Rodríguez, Erika Robers, Dolores D Guest, Andrew Sussman, Yvonne Talamantes, Matthew R Schwartz, Jennie Greb, Jessica Bigney, Kimberly A Kaphingst, Keith Hunley, David B Buller
BACKGROUND: Limited translational genomic research currently exists to guide the availability, comprehension, and appropriate use of personalized genomics in diverse general population subgroups. Melanoma skin cancers are preventable, curable, common in the general population, and disproportionately increasing in Hispanics. OBJECTIVE: Variants in the melanocortin-1 receptor (MC1R) gene are present in approximately 50% of the population, are major factors in determining sun sensitivity, and confer a 2-to-3-fold increase in melanoma risk in the general population, even in populations with darker skin...
April 25, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28442303/clinical-evaluation-of-ropinirole-controlled-release-formulation-at-18-24%C3%A2-mg-day-in-japanese-patients-with-parkinson-s-disease
#11
Nobutaka Hattori, Kazuko Hasegawa, Katsuaki Sato, Erika Mitsuyama, Yotaro Numachi
INTRODUCTION: There has been no clinical data on Japanese patients with Parkinson's disease with which to examine whether motor symptoms improve and to assess the safety profile after the dose of ropinirole was increased in those who had not achieved an optimal response to the ropinirole immediate-release formulation 15 mg/day or the controlled-release (CR) formulation 16 mg/day. METHODS: This was a multicenter, randomized, double-blind study, followed by an open-label, long-term study...
April 13, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28441360/erythromycin-modification-that-improves-its-acidic-stability-while-optimizing-it-for-local-drug-delivery
#12
Erika L Cyphert, Jaqueline D Wallat, Jonathan K Pokorski, Horst A von Recum
The antibiotic erythromycin has limited efficacy and bioavailability due to its instability and conversion under acidic conditions via an intramolecular dehydration reaction. To improve the stability of erythromycin, several analogs have been developed-such as azithromycin and clarithromycin-which decrease the rate of intramolecular dehydration. We set out to build upon this prior work by developing a conjugate of erythromycin with improved pH stability, bioavailability, and preferential release from a drug delivery system directly at the low pH of an infection site...
April 25, 2017: Antibiotics
https://www.readbyqxmd.com/read/28441313/clinical-evidence-for-spinal-cord-stimulation-for-failed-back-surgery-syndrome-fbss-systematic-review
#13
Leonardo Kapural, Erika Peterson, David A Provenzano, Peter Staats
STUDY DESIGN: A systematic review OBJECTIVE.: A systematic literature review of the clinical data from prospective studies was undertaken to assess the efficacy of spinal cord stimulation (SCS) in the treatment of FBSS in adults. SUMMARY OF BACKGROUND DATA: For patients with unrelenting back pain due to mechanical instability of the spine, degenerative disc disease, spinal injury, or deformity, spinal surgery is a well-accepted treatment option; however, even after surgical intervention, many patients continue to experience chronic back pain that can be notoriously difficult to treat...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28441095/perceived-harms-and-social-norms-in-the-use-of-electronic-cigarettes-and-smokeless-tobacco
#14
Erika A Waters, Georgia Mueller-Luckey, Kelsey LeVault, Wiley D Jenkins
Perceptions of harms and social norms influence the use of conventional tobacco cigarettes, but little research is available about their combined relationship with e-cigarette and smokeless tobacco use. We conducted a cross-sectional survey of 309 individuals from central Illinois. We explored (1) demographic predictors of perceived harms and social norms related to e-cigarette and smokeless tobacco use, and (2) whether perceived harms, social norms, or both were important predictors of e-cigarette and smokeless tobacco use...
April 25, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28441001/-mexican-asthma-guidelines-guima-2017
#15
Désirée Larenas-Linnemann, Jorge Salas-Hernández, Juan Carlos Vázquez-García, Ignacio Ortiz-Aldana, Margarita Fernández-Vega, Blanca Estela Del Río-Navarro, María Del Carmen Cano-Salas, Jorge Agustín Luna-Pech, José Antonio Ortega-Martell, Jade Romero-Lombard, Erika Del Carmen López-Estrada, Jimena Villaverde-Rosas, José Luis Mayorga-Butrón, Mario Humberto Vargas-Becerra, Martín Bedolla-Barajas, Noel Rodríguez-Pérez, Ambrocio Aguilar-Aranda, Carlos Adrián Jiménez-González, Carlos García-Bolaños, Claudia Garrido-Galindo, David Alejandro Mendoza-Hernández, Enrique Mendoza-López, Gerardo López-Pérez, Guillermo Hideo Wakida-Kuzonoki, Héctor Hernán Ruiz-Gutiérrez, Héctor León-Molina, Héctor Martínez-De la Lanza, Héctor Stone-Aguilar, Javier Gómez-Vera, Jorge Olvera-Salinas, José Joel Oyoqui-Flores, José Luis Gálvez-Romero, José Santos Lozano-Sáenz, Juan Ignacio Salgado-Gama, Marcos Alejandro Jiménez-Chobillon, Martha Angélica García-Avilés, Martha Patricia Guinto-Balanzar, Miguel Alejandro Medina-Ávalos, Robert Camargo-Angeles, Rogelio García-Torrentera, Saraí Toral-Freyre, Gabriel Montes-Narváez, Héctor Solorio-Gómez, Juan Rosas-Peña, Sergio Jesús Romero-Tapia, Adela Reyes-Herrera, Francisco Cuevas-Schacht, Joaquín Esquer-Flores, José Antonio Sacre-Hazouri, Lorenzo Compean-Martínez, Pablo Julián Medina-Sánchez, Sergio Garza-Salinas, Carlos Báez-Loyola, Iraís Romero-Alvarado, José Luis Miguel-Reyes, Laura Elizabeth Huerta-Espinosa, Manuel Ángel Correa-Flores, Ricardo Castro-Martínez
BACKGROUND: The need for a national guideline, with a broad basis among specialists and primary care physicians was felt in Mexico, to try unifying asthma management. As several high-quality asthma guidelines exist worldwide, it was decided to select the best three for transculturation. METHODS: Following the internationally recommended methodology for guideline transculturation, ADAPTE, a literature search for asthma guidelines, published 1-1-2007 through 31-12-2015 was conducted...
2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28440334/trends-in-perinatal-mortality-and-its-risk-factors-in-japan-analysis-of-vital-registration-data-1979-2010
#16
Maaya Kita Sugai, Stuart Gilmour, Erika Ota, Kenji Shibuya
As Japan has achieved one of the lowest perinatal mortality rates (PMR), our study aims to estimate trends in and risk factors for perinatal mortality among singleton births in Japan. We used Japanese vital registration data to assess trends in and risk factors for perinatal outcomes between 1979 and 2010. Birth and death registration data were merged. An autoregressive integrated moving average model was fitted separately by sex to the PMR and the proportion of stillbirths. A multilevel Poisson regression model was used to estimate risk factors for perinatal mortality...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438790/psychiatric-associations-of-adult-onset-focal-dystonia-phenotypes
#17
Brian D Berman, Johanna Junker, Erika Shelton, Stefan H Sillau, H A Jinnah, Joel S Perlmutter, Alberto J Espay, Joseph Jankovic, Marie Vidailhet, Cecilia Bonnet, William Ondo, Irene A Malaty, Ramón Rodríguez, William M McDonald, Laura Marsh, Mateusz Zurowski, Tobias Bäumer, Norbert Brüggemann
BACKGROUND: Depression and anxiety frequently accompany the motor manifestations of isolated adult-onset focal dystonias. Whether the body region affected when this type of dystonia first presents is associated with the severity of these neuropsychiatric symptoms is unknown. OBJECTIVES: The aim of this study was to determine whether depression, anxiety and social anxiety vary by dystonia onset site and evaluate whether pain and dystonia severity account for any differences...
April 24, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28438409/health-workers-attitudes-perceptions-and-knowledge-of-influenza-immunization-in-lima-peru-a-mixed-methods-study
#18
Magdalena Bazán, Erika Villacorta, Gisella Barbagelatta, M Michelle Jimenez, Cecilia Goya, Rosario M Bartolini, Mary E Penny
BACKGROUND: Vaccination against seasonal influenza in health workers is recommended but coverage is variable. This study aimed to determine coverage of influenza vaccination among health workers in Lima, Peru in 2010; explore barriers and enabling elements for vaccination; and suggest strategies to improve coverage. METHODS: Qualitative interviews informed the development of a survey instrument that consisted of open and close-ended questions. Sub-analyses were done by occupational group and results were calculated as percentages for each possible response with confidence intervals of 95%...
April 21, 2017: Vaccine
https://www.readbyqxmd.com/read/28438269/stone-eating-fungi-mechanisms-in-bioweathering-and-the-potential-role-of-laccases-in-black-slate-degradation-with-the-basidiomycete-schizophyllum-commune
#19
Julia Kirtzel, Daniela Siegel, Katrin Krause, Erika Kothe
Many enzymes, such as laccases, are involved in the saprotrophic lifestyle of fungi and the effects of those may be linked to enhanced bioweathering on stone surfaces. To test this hypothesis, we studied the decomposition of kerogen-enriched lithologies, especially with black slate containing up to 20% of Corg. Indeed, a formation of ditches with attached hyphal material could be observed. To address enzymes involved, proteomics was performed and one group of enzymes, the multicopper oxidase family members of laccases, was specifically investigated...
2017: Advances in Applied Microbiology
https://www.readbyqxmd.com/read/28437445/knowledge-and-perception-of-cardiovascular-disease-risk-among-patients-with-rheumatoid-arthritis
#20
Sunjoo Boo, Hyunjin Oh, Erika S Froelicher, Chang-Hee Suh
Patients with rheumatoid arthritis are at increased risk for cardiovascular disease. The prerequisites for reducing the risk of cardiovascular disease are adequate levels of knowledge and being aware of the risk. In this study, the levels of knowledge about cardiovascular disease among patients with rheumatoid arthritis and the perception were evaluated in relation to their actual 10-year risk of cardiovascular disease. This cross-sectional study of 200 patients with rheumatoid arthritis was conducted in a university-affiliated hospital in South Korea...
2017: PloS One
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