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https://www.readbyqxmd.com/read/29223716/alkaline-degradation-of-lyophilized-dmsa-prior-to-labeling-with-99mtc-identification-and-development-of-the-degradation-pathway-by-hplc-and-ms
#1
Erika V Almeida, Samuel L De Brito
INTRODUCTION: Complexes of technetium-99m (99mTc) with meso-dimercaptosuccinic acid (DMSA) have been widely used as diagnostic agents in nuclear medicine. The degradation products (DP) of DMSA formed under different forced conditions have been identified through HPLC-DAD and LC-MSn studies. In this study, the DMSA kit was subjected to forced degradation under hydrolysis conditions as prescribed by the International Conference on Harmonization (ICH) guideline Q1A. METHODS: Chromatographic separation was accomplished on a reverse phase Shim-Pack VP-ODS (150 mm × 4...
November 10, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29223686/nourishing-networks-a-social-ecological-analysis-of-a-network-intervention-for-improving-household-nutrition-in-western-kenya
#2
Autumn L DeLorme, Erika R Gavenus, Charles R Salmen, Gor Ouma Benard, Brian Mattah, Elizabeth Bukusi, Kathryn J Fiorella
RATIONALE: A growing body of research emphasizes the need to engage social networks in maternal and child nutrition interventions. However, an understanding of how interventions functionally engage not only mothers but fathers, grandparents, friends, and other social network members remains limited. OBJECTIVE: This study uses an adaptation of a social-ecological model to analyze the multiple levels at which the Kanyakla Nutrition Program operates to change behavior...
November 20, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29222910/associations-between-maoa-uvntr-genotype-maltreatment-maoa-methylation-and-alcohol-consumption-in-young-adult-males
#3
Megha Bendre, Erika Comasco, Dave Checknita, Jari Tiihonen, Sheilagh Hodgins, Kent W Nilsson
BACKGROUND: Epigenetic mechanisms are candidate moderators of the effect of maltreatment on brain and behavior. Interactions between maltreatment and the Monoamine Oxidase A upstream variable number tandem repeat genotype (MAOA-uVNTR) are associated with alcohol-related problems. However, presently it is not known whether DNA methylation moderates this association. The study focused on fifty-three young adult males and aimed to determine: whether MAOA methylation moderated the association of alcohol-related problems with the interaction of MAOA-uVNTR and maltreatment; and whether alcohol consumption moderated the association of MAOA methylation with the interaction of MAOA-uVNTR and maltreatment...
December 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29222611/kiwifruit-svp2-controls-developmental-and-drought-stress-pathways
#4
Rongmei Wu, Tianchi Wang, Ben A W Warren, Susan J Thomson, Andrew C Allan, Richard C Macknight, Erika Varkonyi-Gasic
Genome-wide targets of Actinidia chinensis SVP2 confirm roles in ABA- and dehydration-mediated growth repression and reveal a conservation in mechanism of action between SVP genes of taxonomically distant Arabidopsis and a woody perennial kiwifruit. The molecular mechanisms underlying growth and dormancy in woody perennials are largely unknown. In Arabidopsis, the MADS-box transcription factor SHORT VEGETATIVE PHASE (SVP) plays a key role in the progression from vegetative to floral development, and in woody perennials SVP-like genes are also proposed to be involved in controlling dormancy...
December 8, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/29221995/antimicrobial-susceptibility-testing-of-colistin-evaluation-of-seven-commercial-mic-products-against-standard-broth-microdilution-for-escherichia-coli-klebsiella-pneumoniae-pseudomonas-aeruginosa-and-acinetobacter-spp
#5
Erika Matuschek, Jenny Åhman, Catherine Webster, Gunnar Kahlmeter
OBJECTIVE: Both EUCAST and CLSI recommend broth microdilution (BMD) for antimicrobial susceptibility testing of colistin, but BMD is rarely used in routine microbiology laboratories. The objective of this study was to evaluate five commercially available BMD products and two brands of gradient tests for colistin MIC determination using BMD according to ISO standard 20776-1 as reference. METHODS: Colistin MIC determination was performed according to the manufacturer's instructions on five commercially available BMD products (Sensititre, MICRONAUT-S, MICRONAUT MIC-Strip, SensiTest and UMIC) and two gradient tests (Etest and MIC Test Strip)...
December 5, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29221691/characteristics-and-outcomes-of-pediatric-heart-failure-related-emergency-department-visits-in-the-united-states-a-population-based-study
#6
Erika J Mejia, Matthew J O'Connor, Kimberly Y Lin, Lihai Song, Heather Griffis, Christopher E Mascio, Pirouz Shamszad, Aaron Donoghue, Chitra Ravishankar, Robert E Shaddy, Joseph W Rossano
OBJECTIVES: To describe the frequency, characteristics, and outcomes of heart failure-related emergency department (ED) visits in pediatric patients. We aimed to test the hypothesis that these visits are associated with higher admission rates, mortality, and resource utilization. STUDY DESIGN: A retrospective analysis of the Nationwide Emergency Department Sample for 2010 of patients ≤18 years of age was performed to describe ED visits with and without heart failure...
December 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29220623/the-aging-well-through-interaction-and-scientific-education-agewise-program
#7
Maureen K O'Connor, Malissa L Kraft, Ryan Daley, Michael A Sugarman, Erika L Clark, Arielle A J Scoglio, Steven D Shirk
OBJECTIVE: We conducted a randomized controlled trial of the Aging Well through Interaction and Scientific Education (AgeWISE) program, a 12-week manualized cognitive rehabilitation program designed to provide psychoeducation to older adults about the aging brain, lifestyle factors associated with successful brain aging, and strategies to compensate for age related cognitive decline. METHODS: Forty-nine cognitively intact participants ≥ 60 years old were randomly assigned to the AgeWISE program (n = 25) or a no-treatment control group (n = 24)...
November 2, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29220427/steroid-but-not-biological-therapy-elevates-the-risk-of-venous-thromboembolic-events-in-inflammatory-bowel-disease-a-meta-analysis
#8
Patricia Sarlos, Kata Szemes, Peter Hegyi, Andras Garami, Imre Szabo, Anita Illes, Margit Solymar, Erika Petervari, Aron Vincze, Gabriella Par, Judit Bajor, Jozsef Czimmer, Orsolya Huszar, Peter Varju, Nelli Farkas
Background and aim: Inflammatory bowel disease [IBD] is associated with 1.5- to 3-fold increased risk of venous thromboembolic events [VTE]. The aim of this study was to determine the risk of VTE in IBD as a complication of systemic corticosteroids and anti-tumor necrosis factor alpha [TNFα] therapies. Methods: A systematic review and meta-analysis was conducted, which conforms to the Preferred Reporting Items for Systematic Reviews and Meta-analyses [PRISMA] statement...
December 6, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29219210/bioenergetic-regulation-of-microglia
#9
REVIEW
Soumitra Ghosh, Erika Castillo, Elma S Frias, Raymond A Swanson
Microglia have diverse actions, ranging from synapse pruning in development to cytotoxic effects in disease. Brain energy metabolism and substrate availability vary under normal and disease states, but how these variations influence microglial function is relatively unknown. Microglia, like most other cell types, express the full complement of gene products required for both glycolytic and oxidative metabolism. Evidence suggests that microglia increase aerobic glycolysis and decrease respiration when activated by various stimuli...
December 8, 2017: Glia
https://www.readbyqxmd.com/read/29218364/ultrasound-evaluation-of-stress-injuries-and-physiological-adaptations-in-the-fingers-of-adolescent-competitive-rock-climbers
#10
Kathryn Garcia, Diego Jaramillo, Erika Rubesova
BACKGROUND: The impact of high-intensity, repetitive training on the fingers of adolescent climbers is relatively unknown. OBJECTIVE: To evaluate this effect by ultrasound (US) and to confirm some findings by magnetic resonance imaging (MRI). MATERIALS AND METHODS: The US study was performed in 20 adolescent rock climbers (ages 10-17 years) and 6 non-climbing controls (ages 11-15 years). US was used to examine the third digit of the right hand for differences in thickness of soft tissue, flexor and extensor tendon, volar plate and bony and growth plate adaptations...
December 7, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29218137/low-temperature-limits-for-root-growth-in-alpine-species-are-set-by-cell-differentiation
#11
Sebastian Nagelmüller, Erika Hiltbrunner, Christian Körner
Plant growth in cold climates is not limited by carbon assimilation (source activity) but rather by reduced carbon investment into new tissues (sink limitation). It has been hypothesized that all cold-adapted plants face similar growth constraints at low temperature mainly associated with the formation of new tissues. To explore the thermal limitation of plant tissue formation, we studied root growth and anatomical root tissue characteristics in four cold-adapted alpine species (Ranunculus glacialis, Rumex alpinus, Tussilago farfara, Poa alpina), grown in thermostated soils with a vertical temperature gradient approaching 1 °C...
November 2017: AoB Plants
https://www.readbyqxmd.com/read/29217671/positive-change-in-feedback-perceptions-and-behavior-a-10-year-follow-up-study
#12
Dorene F Balmer, Rebecca Tenney-Soeiro, Erika Mejia, Beth Rezet
BACKGROUND: Providing and learning from feedback are essential components of medical education, and typically described as resistant to change. But given a decade of change in the clinical context in which feedback occurs, the authors asked if, and how, perceptions of feedback and feedback behaviors might have changed in response to contextual affordances. METHODS: In 2017, the authors conducted a follow-up, ethnographic study on 2 general pediatric floors at the same children's hospital where another ethnographic study on a general pediatric floor was conducted in 2007...
December 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/29217296/smaller-hippocampal-volume-in-posttraumatic-stress-disorder-a-multisite-enigma-pgc-study-subcortical-volumetry-results-from-posttraumatic-stress-disorder-consortia
#13
Mark W Logue, Sanne J H van Rooij, Emily L Dennis, Sarah L Davis, Jasmeet P Hayes, Jennifer S Stevens, Maria Densmore, Courtney C Haswell, Jonathan Ipser, Saskia B J Koch, Mayuresh Korgaonkar, Lauren A M Lebois, Matthew Peverill, Justin T Baker, Premika S W Boedhoe, Jessie L Frijling, Staci A Gruber, Ilan Harpaz-Rotem, Neda Jahanshad, Sheri Koopowitz, Ifat Levy, Laura Nawijn, Lauren O'Connor, Miranda Olff, David H Salat, Margaret A Sheridan, Jeffrey M Spielberg, Mirjam van Zuiden, Sherry R Winternitz, Jonathan D Wolff, Erika J Wolf, Xin Wang, Kristen Wrocklage, Chadi G Abdallah, Richard A Bryant, Elbert Geuze, Tanja Jovanovic, Milissa L Kaufman, Anthony P King, John H Krystal, Jim Lagopoulos, Maxwell Bennett, Ruth Lanius, Israel Liberzon, Regina E McGlinchey, Katie A McLaughlin, William P Milberg, Mark W Miller, Kerry J Ressler, Dick J Veltman, Dan J Stein, Kathleen Thomaes, Paul M Thompson, Rajendra A Morey
BACKGROUND: Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. METHODS: We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date...
September 20, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29217121/diagnostic-and-treatment-effects-of-sialendoscopy-for-patients-with-swelling-of-the-parotid-gland-when-sialoliths-are-undetected-with-computed-tomography
#14
Norio Kondo, Toshio Yoshihara, Yukie Yamamura, Kaoru Kusama, Eri Sakitani, Yukako Seo, Mayako Tachikawa, Keiko Kujirai, Erika Ono, Yasuyo Maeda, Tomohito Nojima, Akiko Tamiya, Emiri Sato, Manabu Nonaka
Between August 2009 and May 2016, 74 patients underwent sialoendoscopic surgery. 32 patients had parotid gland disease and 9 patients had intermittent swelling of the parotid gland and sialoliths were not detected with CT imaging. 4 patients were diagnosed with idiopathic Stensen's duct stenosis. Sialendoscopy directly confirmed Stensen's duct stenosis in 2 patients. However, the sialendoscope was unable to be inserted in the other 2 patients, who had stenosis of the orifice of the Stensen's duct. Balloon expansion of the duct was performed in these 2 patients and a steroid drug was injected into the duct in one patient...
December 4, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29216912/changes-in-salivary-oxytocin-after-inhalation-of-clary-sage-essential-oil-scent-in-term-pregnant-women-a-feasibility-pilot-study
#15
Yuriko Tadokoro, Shigeko Horiuchi, Kaori Takahata, Takuya Shuo, Erika Sawano, Kazuyuki Shinohara
OBJECTIVES: This pilot study using a quasi-experimental design was conducted to evaluate the feasibility (i.e., limited efficacy, practicality, and acceptability) of our intervention protocol involving inhalation of the scent of clary sage essential oil by pregnant women and measurement of their preinhalation and postinhalation oxytocin levels. RESULTS: Participants were women of singleton pregnancies between 38 and 40 gestation weeks (N = 11). The experiment group (n = 5) inhaled the scent of clary sage essential oil diluted 50-fold with 10 mL of odorless propylene glycol for 20 min...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29216770/maternal-age-over-40-years-and-pregnancy-outcome-a-hospital-based-survey
#16
Luca Marozio, Elisa Picardo, Claudia Filippini, Erika Mainolfi, Paola Berchialla, Franco Cavallo, Annalisa Tancredi, Chiara Benedetto
OBJECTIVE: Increased risk for adverse pregnancy outcomes with advancing maternal age has been described but the strength of association remains debated, particularly in presence of confounding factors such as parity, twin pregnancy and pregnancy from assisted reproductive technologies. The aim of this study was to evaluate pregnancy outcomes in a large cohort of women aged over 40 years. The hypothesis was that advanced maternal age may be an independent risk factor for adverse pregnancy outcome...
December 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29216482/enantiomeric-profiling-of-chiral-illicit-drugs-in-a-pan-european-study
#17
Erika Castrignanò, Zhugen Yang, Richard Bade, Jose A Baz-Lomba, Sara Castiglioni, Ana Causanilles, Adrian Covaci, Emma Gracia-Lor, Felix Hernandez, Juliet Kinyua, Ann-Kathrin McCall, Alexander L N van Nuijs, Christoph Ort, Benedek G Plósz, Pedram Ramin, Nikolaos I Rousis, Yeonsuk Ryu, Kevin V Thomas, Pim de Voogt, Ettore Zuccato, Barbara Kasprzyk-Hordern
The aim of this paper is to present the first study on spatial and temporal variation in the enantiomeric profile of chiral drugs in eight European cities. Wastewater-based epidemiology (WBE) and enantioselective analysis were combined to evaluate trends in illicit drug use in the context of their consumption vs direct disposal as well as their synthetic production routes. Spatial variations in amphetamine loads were observed with higher use in Northern European cities. Enantioselective analysis showed a general enrichment of amphetamine with the R-(-)-enantiomer in wastewater indicating its abuse...
December 1, 2017: Water Research
https://www.readbyqxmd.com/read/29216333/a-donor-specific-qtl-exhibiting-allelic-variation-for-leaf-sheath-hairiness-in-a-nested-association-mapping-population-is-located-on-barley-chromosome-4h
#18
Stephanie Saade, Burcu Kutlu, Vera Draba, Karin Förster, Erika Schumann, Mark Tester, Klaus Pillen, Andreas Maurer
Leaf sheath hairiness is a morphological trait associated with various advantages, including tolerance to both abiotic and biotic stresses, thereby increasing yield. Understanding the genetic basis of this trait in barley can therefore improve the agronomic performance of this economically important crop. We scored leaf sheath hairiness in a two-year field trial in 1,420 BC1S3 lines from the wild barley nested association mapping (NAM) population HEB-25. Leaf sheath hairiness segregated in six out of 25 families with the reference parent Barke being glabrous...
2017: PloS One
https://www.readbyqxmd.com/read/29215675/association-between-apical-periodontitis-and-tnf-%C3%AE-308-g-a-gene-polymorphism-a-systematic-review-and-meta-analysis
#19
Alessandro Guimarães Salles, Lívia Azeredo Alves Antunes, Patrícia Arriaga Carvalho, Erika Calvano Küchler, Leonardo Santos Antunes
Currently, investigations have focused on the identification of Single Nucleotide Polymorphisms (SNP) involved in host response and its ability to generate an immunity deficiency. The aim of this study was to perform a systematic review (SR) and meta-analysis to evaluate the association between TNF-α -308 G>A polymorphism and apical periodontitis (AP) phenotypes. A broad search for studies was conducted. The following databases were used: PubMed, Scopus, Web of Science, and VHL (Medline, SciELO, Ibecs, and Lilacs)...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29214813/development-implementation-and-evaluation-of-active-lions-a-campaign-to-promote-active-travel-to-a-university-campus
#20
Melissa Bopp, Dangaia Sims, Stephen A Matthews, Liza S Rovniak, Erika Poole, Joanna Colgan
PURPOSE: To outline the development, implementation, and evaluation of a multistrategy intervention to promote active transportation, on a large university campus. DESIGN: Single group pilot study. SETTING: A large university in the Northeastern United States. PARTICIPANTS: University students (n = 563), faculty and staff (employees, n = 999) were included in the study. INTERVENTION: The Active Lions campaign aimed to increase active transportation to campus for all students and employees...
January 1, 2017: American Journal of Health Promotion: AJHP
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