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https://www.readbyqxmd.com/read/29656263/early-improvement-as-a-predictor-of-final-remission-in-major-depressive-disorder-new-insights-in-electroconvulsive-therapy
#1
Erika Martínez-Amorós, Ximena Goldberg, Verònica Gálvez, Aida de Arriba-Arnau, Virginia Soria, José M Menchón, Diego J Palao, Mikel Urretavizcaya, Narcís Cardoner
BACKGROUND: Early improvement to antidepressant drugs predicts remission, but the predictive value of early improvement to electroconvulsive therapy (ECT) is still unclear. The main aim of this study was to determine the optimal definition of early improvement in the treatment of major depressive disorder (MDD) with ECT, by analyzing its value as a predictor of remission. METHODS: A naturalistic study was conducted in 87 adult MDD patients treated with acute ECT...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29656112/influence-of-immunosuppressive-drugs-on-the-cd30-molecule-in-kidney-transplanted-patients
#2
Patricia Cristina Grenzi, Érika Fernandes Campos, Hélio Tedesco-Silva, Claudia Rosso Felipe, Maria Fernanda Soares, José Medina-Pestana, Hinrich Peter Hansen, Maria Gerbase-DeLima
BACKGROUND: Soluble CD30 (sCD30) is a suggested marker for kidney transplantation outcomes. We investigated whether sCD30 serum levels are influenced by immunosuppression and whether they correlate with findings in protocol biopsies and with CD30 gene expression in peripheral blood mononuclear cells (PBMC). METHODS: We studied 118 kidney transplant recipients that initially received tacrolimus (TAC) and, at month-3, were converted or not to sirolimus (SRL). RESULTS: sCD30 serum levels gradually declined after transplantation, being the decline more pronounced in the SRL group...
April 12, 2018: Human Immunology
https://www.readbyqxmd.com/read/29653128/serotonin-specific-lesions-of-the-dorsal-raphe-disrupt-maternal-aggression-and-caregiving-in-postpartum-rats
#3
M Allie Holschbach, Erika V Vitale, Joseph S Lonstein
The behavioral modifications associated with early motherhood, including high aggression, caring for young, and low anxiety are all affected by acute pharmacological manipulation of serotonin signaling. However, the effects on these behaviors of permanently disrupting serotonin signaling at one of its primary sources, the dorsal raphe (DR), have not been examined in detail. To address this, serotonin-specific lesions centered on the dorsomedial DR (DRdm; subregion most implicated in emotional behaviors) were induced at mid-pregnancy (day 15) or early postpartum (day 2) in rats using a saporin-conjugated neurotoxin targeting the serotonin transporter (Anti-SERT-SAP)...
April 10, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29652742/use-of-linezolid-in-a-child-with-tuberculous-meningitis
#4
Maria Vittoria De Vita, Erika Silvestro, Carlotta Canavese, Valentina Pennacchietti, Carlo Scolfaro
No abstract text is available yet for this article.
May 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29652687/ultrasound-guided-transversalis-fascia-plane-block-an-alternative-approach-for-anesthesia-in-inguinal-herniorrhaphy-a-case-report
#5
Paolo Scimia, Erika Basso Ricci, Emiliano Petrucci, Astrid Ursula Behr, Franco Marinangeli, Pierfrancesco Fusco
Ultrasound (US)-guided transversalis fascia plane block (TFPB) was first described by Hebbard as a technique for blockade of T12-L1 nerves. Although this technique appears similar to the quadratus lumborum 1 block, the point of injection is more caudal and anterior, specifically targeting ilioinguinal and iliohypogastric nerves. There are only few published data on US-guided TFPB demonstrating effective postoperative analgesia in iliac crest bone graft harvesting. We report the use of US-guided TFPB in a patient undergoing inguinal herniorrhaphy...
April 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29652093/and-the-winner-of-the-inaugural-sidnie-manton-award-is%C3%A2
#6
EDITORIAL
Kenneth Wilson, Ben C Sheldon, Jean-Michel Gaillard, Nathan J Sanders, Simon P G Hoggart, Erika Newton
No abstract text is available yet for this article.
May 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29651320/movement-activity-determination-with-health-related-variables-of-university-students-in-kosice
#7
Peter Bakalár, Martin Zvonar, Jaromir Sedlacek, Rut Lenkova, Peter Sagat, Lubos Vojtasko, Erika Liptakova, Miroslava Barcalova
Introduction: There is currently a strong scientific evidence about the negative health consequences of physical inactivity. One of the potential tools for promoting physical activity at the institutional level of the Ecological model is to create conditions and settings that would enable pupils, students and employees engage in some form of physical activity. However, physical activities as a subject are being eliminated from the study programs at Slovak universities. The purpose of the study was to find current evidence about the level of structured physical activity and health-related variables in university students in Košice...
June 2018: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/29651165/the-mitochondrial-citrate-carrier-slc25a1-drives-stemness-and-therapy-resistance-in-non-small-cell-lung-cancer
#8
Harvey R Fernandez, Shreyas M Gadre, Mingjun Tan, Garrett T Graham, Rami Mosaoa, Martin S Ongkeko, Kyu Ah Kim, Rebecca B Riggins, Erika Parasido, Iacopo Petrini, Simone Pacini, Amrita Cheema, Rency Varghese, Habtom W Ressom, Yuwen Zhang, Christopher Albanese, Aykut Üren, Mikell Paige, Giuseppe Giaccone, Maria Laura Avantaggiati
Therapy resistance represents a clinical challenge for advanced non-small cell lung cancer (NSCLC), which still remains an incurable disease. There is growing evidence that cancer-initiating or cancer stem cells (CSCs) provide a reservoir of slow-growing dormant populations of cells with tumor-initiating and unlimited self-renewal ability that are left behind by conventional therapies reigniting post-therapy relapse and metastatic dissemination. The metabolic pathways required for the expansion of CSCs are incompletely defined, but their understanding will likely open new therapeutic opportunities...
April 12, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29650492/robotically-driven-orthoses-exert-proximal-to-distal-differential-recovery-on-the-lower-limbs-in-children-with-hemiplegia-early-after-acquired-brain-injury
#9
Elena Beretta, Erika Molteni, Emilia Biffi, Roberta Morganti, Paolo Avantaggiato, Sandra Strazzer
Robotically-driven orthoses (RDO) are promising for treating gait impairment in children with hemiplegia after acquired brain injury (ABI). Despite this, existing literature on the employment of RDO in ABI is scanty, and cohorts' age spans throughout the adult age, with no specific focus on the developmental age. We aim to compare a treatment solely based on conventional physiotherapy (CP) with a program combining RDO training with CP, and to examine the effect of time following ABI on recovery. A prospective two-cohorts study was conducted in a rehabilitation hospital...
March 23, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29650426/-optimisation-of-measures-to-protect-premature-neonates-of-less-than-35-weeks-from-the-cold-in-the-first-hour-of-life
#10
Ana Herranz Barbero, Erika Sánchez Ortiz, M ª Dolors Salvia-Roigés, Rocío Cortés Albuixech, José Manuel Rodríguez-Miguélez
No abstract text is available yet for this article.
April 9, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29650277/pharmacogenetics-of-androgen-signaling-in-prostate-cancer-focus-on-castration-resistance-and-predictive-biomarkers-of-response-to-treatment
#11
REVIEW
Marzia Del Re, Stefania Crucitta, Giuliana Restante, Eleonora Rofi, Elena Arrigoni, Elisa Biasco, Andrea Sbrana, Erika Coppi, Luca Galli, Sergio Bracarda, Daniele Santini, Romano Danesi
Tumor heterogeneity strongly affects the molecular mechanisms driving resistance to hormonal therapies in castration-resistant prostate cancer. Since the current use of available treatments can be optimized on the basis of the molecular profile of tumor, the present review focuses on genetic biomarkers in prostate cancer and their application to a personalized treatment.
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29644082/characterisation-of-anifrolumab-a-fully-human-anti-interferon-receptor-antagonist-antibody-for-the-treatment-of-systemic-lupus-erythematosus
#12
Jeffrey M Riggs, Richard N Hanna, Bhargavi Rajan, Kamelia Zerrouki, Jodi L Karnell, Divya Sagar, Inna Vainshtein, Erika Farmer, Kimberly Rosenthal, Chris Morehouse, Melissa de Los Reyes, Kevin Schifferli, Meina Liang, Miguel A Sanjuan, Gary P Sims, Roland Kolbeck
Objective: We investigated the mechanistic and pharmacological properties of anifrolumab, a fully human, effector-null, anti-type I interferon (IFN) alpha receptor 1 (IFNAR1) monoclonal antibody in development for SLE. Methods: IFNAR1 surface expression and internalisation on human monocytes before and after exposure to anifrolumab were assessed using confocal microscopy and flow cytometry. The effects of anifrolumab on type I IFN pathway activation were assessed using signal transducer and activator of transcription 1 (STAT1) phosphorylation, IFN-stimulated response element-luciferase reporter cell assays and type I IFN gene signature induction...
2018: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29642975/management-of-a-complex-case-of-a-bronchopleural-fistula
#13
Erika L Simmerman, Andrew Simmerman, Nathan Walsh, Melissa Shafer, Zhonglin Hao, Carsten Schroeder
No abstract text is available yet for this article.
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29629847/understanding-the-cognitive-and-affective-mechanisms-that-underlie-proxy-risk-perceptions-among-caregivers-of-asthmatic-children
#14
James A Shepperd, Nikolette P Lipsey, Thorsten Pachur, Erika A Waters
OBJECTIVE: Medical decisions made on behalf of another person-particularly those made by adult caregivers for their minor children-are often informed by the decision maker's beliefs about the treatment's risks and benefits. However, we know little about the cognitive and affective mechanisms influencing such "proxy" risk perceptions and about how proxy risk perceptions are related to prominent judgment phenomena. METHODS: Adult caregivers of minor children with asthma ( N = 132) completed an online, cross-sectional survey assessing 1) cognitions and affects that form the basis of the availability, representativeness, and affect heuristics; 2) endorsement of the absent-exempt and the better-than-average effect; and 3) proxy perceived risk and unrealistic comparative optimism of an asthma exacerbation...
April 1, 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29629728/the-impact-of-drug-metabolism-gene-polymorphisms-on-therapeutic-response-and-survival-in-diffuse-large-b-cell-lymphoma-patients
#15
Ildikó Pál, Árpád Illés, Lajos Gergely, Tibor Pál, Zita Radnay, Zoltán Szekanecz, Erika Zilahi, László Váróczy
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) accounts for 30% of all non-Hodgkin lymphomas (NHL) and 80% of agressive lymphomas. Besides the traditional International Prognostic Index (IPI), some other factors may also influence the prognosis of DLBCL patients. OBJECTIVES: To study how the genetic polymorphisms in the metabolic pathway influence the event-free and overall survivals and therapeutic responses in DLBCL. METHODS: The study was comprised of 51 patients (32 men, 19 women)...
April 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29629624/identification-of-the-7s-and-11s-globulins-as-percutaneously-sensitizing-soybean-allergens-as-demonstrated-through-epidermal-application-of-crude-soybean-extract
#16
Hiroki Murakami, Takashi Ogawa, Akiho Takafuta, Erika Yano, Nobuhiro Zaima, Tatsuya Moriyama
Cutaneous exposure to food allergens can predispose individuals to food allergies. Soybean, a major allergenic food, is an ingredient in various cosmetic products. However, the types of soybean proteins that are percutaneously sensitizing in humans or animal models remain unknown. In this study, BALB/c mice were dorsally shaved and epicutaneously exposed to a crude soybean extract including sodium dodecyl sulfate or distilled water alone. Specific IgEs secreted in response to 7S globulin (Gly m 5), 11S globulin (Gly m 6), Gly m 3, and Gly m 4 were measured using enzyme-linked immunosorbent assays or immunoblots...
April 8, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29629189/trust-fear-stigma-and-disruptions-community-perceptions-and-experiences-during-periods-of-low-but-ongoing-transmission-of-ebola-virus-disease-in-sierra-leone-2015
#17
Azizeh Nuriddin, Mohamed F Jalloh, Erika Meyer, Rebecca Bunnell, Franklin A Bio, Mohammad B Jalloh, Paul Sengeh, Kathy M Hageman, Dianna D Carroll, Lansana Conteh, Oliver Morgan
Social mobilisation and risk communication were essential to the 2014-2015 West African Ebola response. By March 2015, >8500 Ebola cases and 3370 Ebola deaths were confirmed in Sierra Leone. Response efforts were focused on 'getting to zero and staying at zero'. A critical component of this plan was to deepen and sustain community engagement. Several national quantitative studies conducted during this time revealed Ebola knowledge, personal prevention practices and traditional burial procedures improved as the outbreak waned, but healthcare system challenges were also noted...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29628806/reliability-of-infrared-thermography-images-in-the-analysis-of-the-plantar-surface-temperature-in-diabetes-mellitus
#18
Natália C M Silva, Hirlaine A Castro, Leonardo C Carvalho, Érika C L Chaves, Ludmila O Ruela, Denise H Iunes
Objective: The purpose of this study was to evaluate the intraexaminer and interexaminer reliability of image assessment of infrared thermography of the plantar surface of people with diabetes mellitus. Methods: Fifty-one participants with diabetes were included. The interexaminer reliability (test) consisted of measuring the temperature of the plantar surface by 2 evaluators who separately performed the analysis of thermographic images. The intraexaminer reliability (retest) consisted of the revaluation of the images by a single evaluator 10 days after the first analysis...
March 2018: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29628457/hypocarnitinemia-observed-in-an-infant-treated-with-short-term-administration-of-antibiotic-containing-pivalic-acid
#19
Kimitaka Nakazaki, Erika Ogawa, Mika Ishige, Nobuyuki Ishige, Tatsuo Fuchigami, Shori Takahashi
Carnitine is a water-soluble amino acid derivative required for β-oxidation of long-chain fatty acids. In carnitine cycle abnormalities and low carnitine states, fatty acid β-oxidation is inhibited during fasting, resulting in hypoglycemia. Pivalic acid is a substance used in prodrugs to increase absorption of parent drugs, and antibiotics containing pivalic acid are frequently used as wide spectrum antibiotics for pediatric patients in Japan. Pivalic acid released after absorption is conjugated with free carnitine to form pivaloylcarnitine, which is then excreted in urine...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29628412/the-left-ventricle-in-congenital-diaphragmatic-hernia-implications-for-the-management-of-pulmonary-hypertension
#20
John P Kinsella, Robin H Steinhorn, Mary P Mullen, Rachel K Hopper, Roberta L Keller, D Dunbar Ivy, Eric D Austin, Usha S Krishnan, Erika B Rosenzweig, Jeffrey R Fineman, Allen D Everett, Brian D Hanna, Tilman Humpl, J Usha Raj, Steven H Abman
No abstract text is available yet for this article.
April 5, 2018: Journal of Pediatrics
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