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Conran Joseph, Breiffni Leavy, Sara Mattsson, Lynn Falk, Erika Franzén
BACKGROUND: Translating evidence into practice requires adaptation to facilitate the implementation of efficacious interventions. A novel highly challenging balance training program (HiBalance) was found to improve gait, balance, and physical activity in persons with Parkinson's disease (PD) in an earlier randomized controlled trial. This study aimed to describe the adaptation process and feasibility of implementing the HiBalance program for PD within primary healthcare settings. METHOD: Feasibility was assessed in terms of study processes and scientific evaluation...
June 21, 2018: Brain and Behavior
Erika L Thompson, Christopher W Wheldon, Cheryl A Vamos, Stacey B Griner, Ellen M Daley
While Pap testing has significantly reduced the burden of cervical cancer, not all women follow prevention recommendations of cervical cancer screening every 3 years. Health literacy regarding Pap testing may influence the adoption of this behavior. The objective of this study was to assess the health literacy-related factors associated with Pap testing among a nationally representative sample of women in the USA. The Health Information National Trends Survey Cycles 4.4 and 5.1 were restricted to women 21-65 years of age (N = 2992)...
June 21, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Donatella Treppiedi, Marie-Lise Jobin, Erika Peverelli, Elena Giardino, Titiwat Sungkaworn, Ulrike Zabel, Maura Arosio, Anna Spada, Giovanna Mantovani, Davide Calebiro
The cytoskeletal protein filamin A (FLNA) has been suggested to play an important role in the responsiveness of GH-secreting pituitary tumors to somatostatin receptor subtype 2 (SSTR2) agonists, by regulating SSTR2 expression and signaling. However, the underlying mechanisms are unknown. Here, we use fast multi-color single-molecule microscopy to image individual SSTR2 and FLNA molecules at the surface of living cells with unprecedented spatiotemporal resolution. We find that SSTR2 and FLNA undergo transient interactions, which occur preferentially along actin fibers and contribute to restraining SSTR2 diffusion...
June 19, 2018: Endocrinology
Shigeki Kinuhata, Yasuhiko Takemoto, Mariko Senda, Shiho Nakai, Erika Tsumura, Tatsuyuki Otoshi, Sadahiko Hiratani, Kazuo Fukumoto, Hiroki Namikawa, Yoshihiro Tochino, Mina Morimura, Taichi Shuto, Sadahiko Uchimoto
Background: Detecting and treating dementia at an early stage are important. Although the Revised Hasegawa Dementia Scale (HDS-R) is commonly used to detect dementia, it takes about 10 min to complete. In contrast, the 1-min animal test (OMAT) takes only 1 min to complete and may be a helpful screening test for general practitioners in deciding whether to proceed with administering further diagnostic tests such as the HDS-R. We sought to examine the relationship between the OMAT and HDS-R scores, and determine the cut-off OMAT score that balanced the sensitivity and specificity in identifying HDS-R-positive patients...
2018: Asia Pacific Family Medicine
Claude Murat, Alan Kuo, Kerrie W Barry, Alicia Clum, Rhyan B Dockter, Laure Fauchery, Mirco Iotti, Annegret Kohler, Kurt LaButti, Erika A Lindquist, Anna Lipzen, Emmanuelle Morin, Mei Wang, Igor V Grigoriev, Alessandra Zambonelli, Francis M Martin
The ascomycete Tuber borchii (Pezizomycetes) is a whitish edible truffle that establishes ectomycorrhizal symbiosis with trees and shrubs. This fungus is ubiquitous in Europe and is also cultivated outside Europe. Here, we present the draft genome sequence of T. borchii strain Tbo3840 (97.18 Mb in 969 scaffolds, with 12,346 predicted protein-coding genes).
June 21, 2018: Genome Announcements
Yuki Kato, Yusaku Masago, Chiaki Kondo, Erika Yogo, Mikinori Torii, Atsuko Hishikawa, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate
To identify the molecular profiles of islets from alloxan (ALX)- and streptozotocin (STZ)-treated rats, a microarray-based global gene expression analysis was performed on frozen islets isolated via laser capture microdissection. At 6 weeks old, rats were injected with ALX (40 mg/kg) or STZ (50 or 100 mg/kg) and then euthanized 24 hr later. Histopathological analysis showed β-cell necrosis, macrophage infiltration, and islet atrophy. The extent of these changes was more notable in the STZ groups than in the ALX group...
January 1, 2018: Toxicologic Pathology
Adorján Cristea, Andreea Baricz, Nicolae Leopold, Călin Gabriel Floare, Gheorghe Borodi, Irina Kacso, Septimiu Tripon, Paul Adrian Bulzu, Ștefan Andrei Adrian, Oana Cadar, Erika Andrea Levei, Horia Leonard Banciu
AIM: This study aimed at unprecedented physical and chemical evaluation of the 'green plastics' polyhydroxyalkanoates (PHAs), in an extremely halotolerant Halomonas elongata strain 2FF under high salt concentration. METHODS AND RESULTS: The investigated bacterial strain was isolated from the surface water of the hypersaline Fără Fund Lake. The 16S rRNA gene sequence phylogeny and phenotypic analysis indicated that the isolate belonged to Halomonas elongata. PHA inclusions were observed by Sudan Black B, Nile Red staining and by transmission electron microscopy (TEM) during growth at high salinity (10%, w/v, NaCl) on 1% (w/v) D-glucose...
June 21, 2018: Journal of Applied Microbiology
Séphora Louyse Silva Aquino, Aline Tuane Oliveira da Cunha, Hermilla Torres Pereira, Erika Paula Silva Freitas, Ana Paula Trussardi Fayh, Josivan Gomes Lima, Severina Carla Vieira Cunha Lima, Karine Cavalcanti Maurício Sena-Evangelista, Lucia Fátima Campos Pedrosa
Background: The risk of metabolic syndrome can be influenced by inadequate vitamin D levels, and exposure to sunlight is the main external source of vitamin D. The present study assessed the influence of environmental, biological, and nutritional factors in relation to seasonal 25-hydroxyvitamin D (25OHD) concentration in individuals with metabolic syndrome. Methods: This cross-sectional study enrolled 180 individuals with metabolic syndrome aged between 18 and 80 years...
2018: Diabetology & Metabolic Syndrome
Lukrecija Butorac, Katarina Hančević, Katarina Lukšić, Željko Škvorc, Mario Leko, Erika Maul, Goran Zdunić
The Eastern Adriatic region, encompassing Croatia and Bosnia and Herzegovina, is considered an important area of natural populations of wild grapevines (Vitis vinifera ssp. sylvestris). The wild grapevine arises in the Eastern Adriatic region in a contact zone of the EU-Mediterranean and the sub-Mediterranean characterized by typical karst relief. This study focuses on the chloroplast DNA (cpDNA) analysis of wild grapevines and the biodiversity of accompanying woody species to better understand the genetic variation of the sylvestris populations of the Eastern Adriatic region and to investigate how this variation fits within today's wild grapevine distribution in the European continent...
2018: PloS One
Shashi N Kapadia, Carrie D Johnston, Kristen M Marks, Bruce R Schackman, Erika G Martin
CONTEXT: Curative treatments for hepatitis C virus (HCV) can alter the course of a devastating epidemic, but high drug prices have contributed to restrictions on HCV treatment access. OBJECTIVE: We aimed to learn how state health agencies have responded to the challenges of treatment access for HCV. DESIGN: Qualitative study using semistructured key informant interviews focused on aspects of HCV treatment access between June 2016 and March 2017...
June 20, 2018: Journal of Public Health Management and Practice: JPHMP
Richard A Brown, Kathleen M Palm Reed, Erika Litvin Bloom, Haruka Minami, David R Strong, Carl W Lejuez, Michael J Zvolensky, Steven C Hayes
We previously developed a distress tolerance (DT)-based treatment that showed promising results for smokers with a history of early lapse. In the current study, we conducted a randomized controlled trial of this DT treatment for a general population of smokers not limited to those with a history of early lapse. We randomized 116 participants (41% female) to DT or standard treatment (ST). Both treatments included 1 individual session during Week 1 followed by 7 group sessions during Weeks 2-9 (quit date at Session 4), two 20-min phone sessions, and 8 weeks of transdermal nicotine patch...
June 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
Erika Johnson, Long Vu, Laura E Matarese
Short bowel syndrome (SBS) occurs in patients who have had extensive resection. The primary physiologic consequence is malabsorption, resulting in fluid and electrolyte abnormalities and malnutrition. Nutrient digestion, absorption, and assimilation may also be diminished by disturbances in the production of bile acids and digestive enzymes. Small bowel dilation, dysmotility, loss of ileocecal valve, and anatomical changes combined with acid suppression and antimotility drugs increase the risk of small intestinal bacterial overgrowth, further contributing to malabsorption...
June 21, 2018: Nutrition in Clinical Practice
Véronique Humbertclaude, Benjamin Krams, Erika Nogue, Nicolas Nagot, Daniel Annequin, Barbara Tourniaire, Elisabeth Tournier-Lasserve, Florence Riant, Agathe Roubertie
AIM: Benign paroxysmal torticollis (BPT), benign paroxysmal vertigo (BPV), and benign tonic upward gaze (BTU) are characterized by transient and recurrent episodes of neurological manifestations. The purpose of this study was to analyse the clinical relationships between these syndromes, associated comorbidities, and genetic bases. METHOD: In this cross-sectional study, clinical data of patients with BPT, BPV, or BTU were collected with a focus on developmental achievements, learning abilities, and rehabilitation...
June 21, 2018: Developmental Medicine and Child Neurology
Erika Durinikova, Jana Plava, Silvia Tyciakova, Pavel Skvara, Andrea Vojs Stanova, Zuzana Kozovska, Lucia Kucerova, Miroslava Matuskova
Gene-directed enzyme/prodrug therapy (GDEPT) mediated by mesenchymal stromal cells (MSC) was already approved for clinical study on a progressive disease refractory to standard therapy. In this work, we examined the effect of several GDEPT approaches on chemoresistant cells. First, we derived 5-fluorouracil (5-FU)-resistant variant of human colorectal adenocarcinoma cells HT-29 designated HT-29/EGFP/FUR. Our data show that the upregulation of thymidylate synthase (TS) and downregulation of thymidine phosphorylase (TP), orotate phosphoribosyl transferase (OPRT) and dihydropyrimidine dehydrogenase (DPD) contributed to the 5-FU resistance in cancer cells...
June 21, 2018: Cancer Gene Therapy
Matthis Synofzik, Katherine L Helbig, Florian Harmuth, Tine Deconinck, Pranoot Tanpaiboon, Bo Sun, Wenting Guo, Ruiwu Wang, Erika Palmaer, Sha Tang, G Bradley Schaefer, Janina Gburek-Augustat, Stephan Züchner, Ingeborg Krägeloh-Mann, Jonathan Baets, Peter de Jonghe, Peter Bauer, S R Wayne Chen, Ludger Schöls, Rebecca Schüle
We explored the clinico-genetic basis of spinocerebellar ataxia 29 (SCA29) by determining the frequency, phenotype, and functional impact of ITPR1 missense variants associated with early-onset ataxia (EOA). Three hundred thirty one patients from a European EOA target cohort (n = 120), US-American EOA validation cohort (n = 72), and early-onset epileptic encephalopathy (EOEE) control cohort (n = 139) were screened for de novo ITPR1 variants. The target cohort was also screened for inherited ITPR1 variants...
June 20, 2018: European Journal of Human Genetics: EJHG
Elisa Gobbini, Corinne Cassani, Jacopo Vertemara, Weibin Wang, Fabiana Mambretti, Erika Casari, Patrick Sung, Renata Tisi, Giuseppe Zampella, Maria Pia Longhese
Homologous recombination is triggered by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs). DSB resection requires the Mre11-Rad50-Xrs2 (MRX) complex, which promotes the activity of Exo1 nuclease through a poorly understood mechanism. Here, we describe the Mre11-R10T mutant variant that accelerates DSB resection compared to wild-type Mre11 by potentiating Exo1-mediated processing. This increased Exo1 resection activity leads to a decreased association of the Ku complex to DSBs and an enhanced DSB resection in G1, indicating that Exo1 has a direct function in preventing Ku association with DSBs...
June 19, 2018: EMBO Journal
Sven Eggerstedt, Patricia Fliß, Erika Mönch, Christiane Ostermeyer
No abstract text is available yet for this article.
June 21, 2018: Infection Control and Hospital Epidemiology
Brice J Albert, Chukun Gao, Erika L Sesti, Edward P Saliba, Nicholas Alaniva, Faith J Scott, Snorri Th Sigurdsson, Alexander B Barnes
Solid-state nuclear magnetic resonance (NMR) enables atomic resolution characterization of molecular structure and dynamics within complex heterogeneous samples, but it is typically insensitive. Dynamic nuclear polarization (DNP) increases NMR signal intensity by orders of magnitude and can be performed in combination with magic angle spinning (MAS) for sensitive, high-resolution spectroscopy. Here we report MAS DNP experiments, for the first time, within intact human cells with >40-fold DNP enhancement and a sample temperature below 6 K...
June 20, 2018: Biochemistry
Erika Simone Galvão Pinto, Rosimeire Fontes de Queiroz, Gisele Santana Pereira Carreiro, Luana Jordana Morais, Eliabe Rodrigues de Medeiros, Tereza Cristina Scatena Villa
OBJECTIVE: determine the coordination of Primary Health Care with community resources in the clinical management of tuberculosis. METHOD: descriptive study, of quantitative approach, with participation of one hundred health professionals. Part of a questionnaire was used in evaluating local institutional capacity for the model of chronic conditions care, adapted for tuberculosis care. RESULTS: the coordination between health units, individuals with tuberculosis, and community organizations; the partnerships between institutions and local health councils/committees showed limited capacity...
May 2018: Revista Brasileira de Enfermagem
Erika F Augustine, Christopher A Beck, Heather R Adams, Sara Defendorf, Amy Vierhile, Derek Timm, Jill M Weimer, Jonathan W Mink, Frederick J Marshall
Mycophenolate, an immunosuppressant, is commonly used off-label for autoimmune neurological conditions. In CLN3 disease, a neurodegenerative disorder of childhood, preclinical and clinical data suggest secondary autoimmunity and inflammation throughout the central nervous system are key components of pathogenesis. We tested the short-term tolerability of mycophenolate in individuals with CLN3 disease, in preparation for possible long-term efficacy trials of this drug. We conducted a randomized, double-blind, placebo-controlled, crossover study of mycophenolate in 19 ambulatory individuals with CLN3 disease to determine the safety and tolerability of short-term administration (NCT01399047)...
June 20, 2018: JIMD Reports
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