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https://www.readbyqxmd.com/read/28822340/endothelial-glycocalyx-biomarkers-increase-in-patients-with-infection-during-emergency-department-treatment
#1
Lisa Smart, Stephen P J Macdonald, Sally Burrows, Erika Bosio, Glenn Arendts, Daniel M Fatovich
PURPOSE: Endothelial glycocalyx (EG) shedding may promote organ failure in sepsis. This study describes temporal changes in EG biomarkers from Emergency Department (ED) arrival, and associations with clinical characteristics. MATERIALS AND METHODS: This prospective observational study included 23 patients with simple infection, 86 with sepsis and 29 healthy controls. Serum EG biomarkers included syndecan-1, syndecan-4 and hyaluronan. Samples were taken on enrolment in the ED (T0), 1 hour (T1), 3 hours (T3) and 12 to 24 hours (T24) later...
July 2, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28822304/a-flow-through-elevated-temperature-and-pressure-nmr-apparatus-for-in-situ-co2-sequestration-studies
#2
Erika L Sesti, Jinlei Cui, Sophia E Hayes, Mark S Conradi
We report an apparatus for in-situ nuclear magnetic resonance (NMR) studies of chemical reactions of dissolved (13)CO2 with minerals (rock or powder) under continuous flow. The operating range of the apparatus is 18-150°C and 1-140bar. A flow pump is used to circulate a CO2-water solution, with a heated mixing vessel where CO2 gas equilibrates with a water solution. The NMR probe is built around a strong zirconia ceramic vessel, with o-ring sealed connections; the mineral is contained inside. The horizontal orientation of the zirconia vessels allows use of a radio frequency (rf) solenoid for improved spin sensitivity...
August 12, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28822091/effect-of-ap102-a-subtype-2-and-5-specific-somatostatin-analog-on-glucose-metabolism-in-rats
#3
Erika Tarasco, Petra Seebeck, Svende Pfundstein, Adrian F Daly, Philippe J Eugster, Alan G Harris, Eric Grouzmann, Thomas A Lutz, Christina N Boyle
PURPOSE: Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as octreotide and lanreotide, have high affinity for somatostatin receptor subtype 2 (SSTR2), but have incomplete efficacy in many patients. Pasireotide targets multiple SSTRs, having the highest affinity for SSTR5, but causes hyperglycemia and diabetes mellitus in preclinical and clinical studies...
August 18, 2017: Endocrine
https://www.readbyqxmd.com/read/28821679/upf1-governs-synaptic-plasticity-through-association-with-a-stau2-rna-granule
#4
Tyson E Graber, Erika Freemantle, Mina Anadolu, Sarah Hébert-Seropian, Robyn MacAdam, Unkyung Shin, Huy-Dung Hoang, Tommy Alain, Jean-Claude Lacaille, Wayne S Sossin
Neuronal mRNAs can be packaged in reversibly stalled polysome granules prior to their transport to distant synaptic locales. Stimulation of synaptic metabotropic glutamate receptors (mGluRs) reactivates translation of these particular mRNAs to produce plasticity-related protein; a phenomenon exhibited during mGluR-mediated long-term depression (mGluR-LTD). This form of plasticity is deregulated in Fragile X Syndrome, a monogenic form of autism in humans, and understanding the stalling and reactivation mechanism could reveal new approaches to therapies...
August 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28820510/implementation-and-use-of-a-patient-symptom-diary-during-chemotherapy-a-mixed-methods-evaluation-of-the-nurse-perspective
#5
Annemarie Coolbrandt, Erika Bruyninckx, Chris Verslype, Ester Steffens, Ellen Vanhove, Hans Wildiers, Koen Milisen
PURPOSE/OBJECTIVES: To gain a deeper understanding of nurses' experience working with a patient diary for tracking and treating side effects during chemotherapy.
. DESIGN: A mixed-methods design was used to learn about oncology nurses' use and perceptions of a symptom diary. 
. SETTING: Six oncology wards and two outpatient clinics at the University Hospitals Leuven, Belgium.
. SAMPLE: 79 nurses completed a survey, and 14 nurses participated in focus group discussions...
September 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28820507/hematopoietic-stem-cell-transplantation-recipient-and-caregiver-factors-affecting-length-of-stay-and-readmission
#6
Thiruppavai Sundaramurthi, Leslie Wehrlen, Erika Friedman, Sue Thomas, Margaret Bevans
PURPOSE/OBJECTIVES: To evaluate the contributions of patient and caregiver factors to length of stay (LOS) and 30-day readmission status for recipients of allogeneic hematopoietic stem cell transplantation (HSCT).
. DESIGN: Secondary data analysis from a phase 2 clinical trial.
. SETTING: National Institutes of Health Clinical Center in Bethesda, Maryland.
. SAMPLE: 68 dyads (N = 136) comprised of patients receiving HSCT and their caregivers...
September 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28820345/erythema-multiforme-triggered-by-treponema-pallidum-infection-in-an-hiv-infected-patient
#7
Luiz Gfab D'Elia Zanella, Érika F Sampaio, Rute F Lellis
We are currently facing a worldwide epidemic of syphilis. Clinical manifestations that are rarely seen have been encountered, leading the dermatologist to confront unusual clinical conditions in daily practice. Erythema multiforme triggered by syphilis is very rare and is also seldom reported in the literature. We report a case of secondary syphilis in an HIV-positive patient, whose clinical, pathologic and serologic features were consistent with the diagnosis of erythema multiforme triggered by syphilis.
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28819822/endovascular-aneurysm-repair-with-balloon-thrombectomy-for-acute-thrombosis-of-abdominal-aortic-aneurysm
#8
Kensuke Uotani, Akihiro Hamanaka, Keigo Matsushiro, Erika Idaka, Kiyo Ito, Yuko Yamasaki, Takeyuki Kushima, Takaki Sugimoto, Koji Sugimoto
Acute occlusion of abdominal aortic aneurysm (AAA) is a rare complication and is usually treated with surgical reconstruction. We present a case of acute AAA occlusion that was successfully treated by endovascular aneurysm repair (EVAR) with Fogarty balloon thrombectomy. A 77-year-old man with a history of acute myocardial ischemia presented with limb weakness and coldness. Contrast-enhanced computed tomography showed a 42-mm-diameter infrarenal AAA that was completely thrombosed in the distal portion. The proximal neck of the aneurysm was patent, and its shape was suitable for EVAR...
August 17, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28819109/tlr4-mediated-placental-pathology-and-pregnancy-outcome-in-experimental-malaria
#9
Renato Barboza, Flávia Afonso Lima, Aramys Silva Reis, Oscar Javier Murillo, Erika Paula Machado Peixoto, Carla Letícia Bandeira, Wesley Luzetti Fotoran, Luis Roberto Sardinha, Gerhard Wunderlich, Estela Bevilacqua, Maria Regina D'Império Lima, José Maria Alvarez, Fabio Trindade Maranhão Costa, Lígia Antunes Gonçalves, Sabrina Epiphanio, Cláudio Romerso Farias Marinho
Malaria-associate pregnancy has a significant impact on infant morbidity and mortality. The detrimental effects of malaria infection during pregnancy have been shown to correlate with immune activation in the placental tissue. Herein we sought to evaluate the effect of Toll-like receptors (TLRs) activation on placental malaria (PM) development by using the Plasmodium berghei NK65(GFP) infection model. We observed that activation of the innate immune system by parasites leads to PM due to local inflammation...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818836/the-care-continuum-an-evolving-model-for-care-and-research-in-rare-diseases
#10
Erika F Augustine, E Ray Dorsey, Peter L Saltonstall
No abstract text is available yet for this article.
August 17, 2017: Pediatrics
https://www.readbyqxmd.com/read/28818247/alcohol-screening-and-brief-intervention-a-potential-role-in-cancer-prevention-for-young-adults
#11
Lela R McKnight-Eily, S Jane Henley, Patricia P Green, Erika C Odom, Daniel W Hungerford
Excessive or risky alcohol use is a preventable cause of significant morbidity and mortality in the U.S. and worldwide. Alcohol use is a common preventable cancer risk factor among young adults; it is associated with increased risk of developing at least six types of cancer. Alcohol consumed during early adulthood may pose a higher risk of female breast cancer than alcohol consumed later in life. Reducing alcohol use may help prevent cancer. Alcohol misuse screening and brief counseling or intervention (also called alcohol screening and brief intervention among other designations) is known to reduce excessive alcohol use, and the U...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28817620/gtsp1-expression-in-non-smoker-and-non-drinker-patients-with-squamous-cell-carcinoma-of-the-head-and-neck
#12
Pamela de Oliveira Soares, Patrícia Maluf Cury, Rossana Verónica Mendoza López, Cláudio Roberto Cernea, Erika Erina Fukuyama, David Livingstone Alves Figueiredo, Francisco Gorgonio da Nobrega, Otavio Alberto Curioni, Fabio Daumas Nunes, Raquel Ajub Moyses, Maria Lúcia Bueno Garcia
INTRODUCTION: The main risk factors for head and neck squamous cell carcinoma (HNSCC) are tobacco and alcohol consumption and human papillomavirus (HPV) infection. However, in a subset of patients, no risk factors can be identified. Glutathione S-transferase π (GTSP1) is a carcinogen-detoxifying enzyme that is activated by exposure to carcinogens, and it is associated with a reduction in response to toxic therapies. We studied the expression of GTSP1 in tumor and non-tumor tissue samples from patients with and without these risks to identify whether GTSP1 expression differs according to exposure to carcinogens...
2017: PloS One
https://www.readbyqxmd.com/read/28817509/high-intensity-exercise-enhances-conduit-artery-vascular-function-in-older-adults
#13
Erika Iwamoto, Josh M Bock, Darren P Casey
PURPOSE: Modulation of vascular function follows an exercise intensity-dependent pattern in young adults. This study aimed to investigate the potential intensity-dependent effects of an acute bout of exercise on conduit and resistance artery function in healthy older adults. METHODS: Eleven healthy older adults (5 males/6 females, 66±1 years) completed 30 minutes of recumbent cycling at 50-55% (low-intensity) and 75-80% (high-intensity) of their age-predicted maximal heart rate on two separate study visits...
August 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28816566/five-year-motor-functional-outcome-in-children-with-acquired-brain-injury-yet-to-the-end-of-the-story
#14
Elena Beretta, Erika Molteni, Sara Galbiati, Giuseppe Stefanoni, Sandra Strazzer
PURPOSE: The description of motor changes and clinical evolution of a pediatric cohort with acquired brain injury (ABI) over 5 years by the functional independence measure for children (WeeFIM). METHODS: We analyzed retrospective data from 496 patients (aged 0-18 years) with severe ABI admitted for rehabilitation. WeeFIM scores and disability rating scale (reference scale) were collected at admission, discharge and yearly, up to year 5. RESULTS: Functional limitations gradually reduced after ABI, but children still had residual disabilities at the endpoint...
August 17, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/28816367/the-in-vitro-and-in-vivo-antiangiogenic-effects-of-flavokawain-b
#15
Mariana C Rossette, Débora C Moraes, Erika K Sacramento, Marco Aurélio Romano-Silva, Juliana L Carvalho, Dawidson A Gomes, Hanna Caldas, Eitan Friedman, Luciana Bastos-Rodrigues, Luiz De Marco
Angiogenesis is implicated in the development of a variety of pathological processes, most commonly cancer. It is essential for tumor growth and metastasis, making it an important cancer therapeutic target. Naturally occurring substances have led to the discovery of anticancer agents. Flavokawain B (FKB), a chalcone isolated from the root extracts of kava-kava plant, inhibits proliferation and causes apoptosis in vitro and in vivo of various cancer cell lines. The antimetastatic potential of FKB has also been suggested...
August 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28816181/antimicrobial-and-antiproliferative-activity-of-bauhinia-forficata-link-and-cnidoscolus-quercifolius-extracts-commonly-used-in-folk-medicine
#16
Erika P Alves, Rennaly de F Lima, Carolina M de Almeida, Irlan A Freires, Pedro L Rosalen, Ana Ltg Ruiz, Ana F Granville-Garcia, Gustavo P Godoy, Jozinete V Pereira, Edja Mm de Brito Costa
BACKGROUND: Bauhinia forficata and Cnidoscolus quercifolius plants are commonly used in folk medicine. However, few studies have investigated their therapeutic potential. AIM: Herein, we evaluated the antimicrobial activity of B. forficata and C. quercifolius extracts against microorganisms of clinical relevance and their antiproliferative potential against tumor cells. MATERIALS AND METHODS: The following tests were performed: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC)/minimum fungicidal concentration (MFC), inhibition of biofilm adhesion, and effects on cell morphology...
August 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28815580/deciding-to-come-out-to-parents-toward-a-model-of-sexual-orientation-disclosure-decisions
#17
Erika L Grafsky
The purpose of this study was to conduct research to understand nonheterosexual youths' decision to disclose their sexual orientation information to their parents. The sample for this study includes 22 youth between the ages of 14 and 21. Constructivist grounded theory guided the qualitative methodology and data analysis. The findings from this study posit an emerging model of sexual orientation disclosure decisions comprised of four interrelated factors that influence the decision to disclose or not disclose, as well as a description of the mechanism through which disclosure either does or does not occur...
August 16, 2017: Family Process
https://www.readbyqxmd.com/read/28814850/increased-parasympathetic-cardiac-modulation-in-patients-with-acute-exacerbation-of-copd-how-should-we-interpret-it
#18
Erika Zavaglia Kabbach, Adriana Mazzuco, Audrey Borghi-Silva, Ramona Cabiddu, Aline Galvão Agnoleto, Jessica Fernanda Barbosa, Luiz Carlos Soares de Carvalho Junior, Renata Gonçalves Mendes
BACKGROUND: Cardiac autonomic modulation (CAM) is impaired in patients with stable COPD. Exacerbation aggravates the patients' health status and functional capacity. While the clinical and functional effects of exacerbation are known, no studies investigated CAM during exacerbation and whether there is a relationship between CAM and functional capacity and dyspnea. METHODS: Thirty-two patients with moderate to severe COPD were enrolled into two groups: stable COPD (GSta, n=16) and acute exacerbation of COPD (GAE, n=16)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28814388/the-impact-of-poxvirus-vector-priming-protein-co-administration-and-vaccine-intervals-on-hiv-gp120-vaccine-elicited-antibody-magnitude-and-function-in-infant-macaques
#19
Bonnie Phillips, Genevieve G Fouda, Josh Eudailey, Justin Pollara, Alan D Curtis, Erika Kunz, Maria Dennis, Xiaoying Shen, Camden Bay, Michael Hudgens, David Pickup, S Munir Alam, Amir Ardeshir, Pamela A Kozlowski, Koen K A Van Rompay, Guido Ferrari, M Anthony Moody, Sallie Permar, Kristina De Paris
Despite success in reducing vertical HIV transmission by maternal antiretroviral therapy, several obstacles limit its efficacy during breastfeeding, and breast-milk transmission is now the dominant mode of mother-to-child transmission (MTCT) of HIV in infants. Thus, a pediatric vaccine is needed to eradicate oral HIV infections in newborns and infants. Utilizing the infant rhesus macaque model, we compared 3 different vaccine regimens: (i) HIV Env protein only; (ii) a poxvirus vector (MVA)-HIV Env prime/HIV Env protein boost, and (iii) co-administration of HIV Env protein and MVA-HIV Env at all time points...
August 16, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28813676/pharmacologic-or-genetic-targeting-of-glutamine-synthetase-skews-macrophages-toward-an-m1-like-phenotype-and-inhibits-tumor-metastasis
#20
Erika M Palmieri, Alessio Menga, Rosa Martín-Pérez, Annamaria Quinto, Carla Riera-Domingo, Giacoma De Tullio, Douglas C Hooper, Wouter H Lamers, Bart Ghesquière, Daniel W McVicar, Attilio Guarini, Massimiliano Mazzone, Alessandra Castegna
Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy. However, its role in macrophages remains elusive. We report that pharmacologic inhibition of GS skews M2-polarized macrophages toward the M1-like phenotype, characterized by reduced intracellular glutamine and increased succinate with enhanced glucose flux through glycolysis, which could be partly related to HIF1α activation...
August 15, 2017: Cell Reports
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