keyword
https://read.qxmd.com/read/38506406/large-vessel-occlusive-stroke-with-milder-baseline-severity-show-better-collaterals-and-reduced-harm-from-thrombectomy-transfer-delays
#21
JOURNAL ARTICLE
Hannah R Rowling, Dominic Italiano, Leonid Churilov, Logesh Palanikumar, Jackson Harvey, Timothy Kleinig, Mark Parsons, Peter Mitchell, Stephen M Davis, Nyika Kruyt, Bruce Campbell, Henry Zhao
BACKGROUND: Patients with large vessel occlusion (LVO) stroke presenting with milder baseline clinical severity are common and require endovascular thrombectomy. However, such patients are difficult to recognize using pre-hospital severity-based triage tools and therefore are likely to require a secondary inter-hospital transfer if transported to a non-thrombectomy center. Given the potential for milder severity to represent better underlying cerebrovascular collateral circulation, it is unknown whether transfer delays are still associated with poorer post-stroke outcomes in this patient group...
March 20, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38505775/case-report-febrile-infection-related-epilepsy-syndrome-in-a-14-year-old-girl-with-multiple-organ-failure-and-lethal-outcome
#22
Lars Ruttkowski, Ines Wallot, Marie Korell, Elke Daur, Peter Seipelt, Andreas Leonhardt, Stefanie Weber, Nadine Mand
We report a case of an otherwise healthy 14-year-old girl with febrile infection-related epilepsy syndrome (FIRES), multiple organ failure (MOF), and ultimately a lethal outcome. This is a rare case of FIRES with MOF and consecutive death. Only a few cases have been described in the literature. The adolescent girl was initially admitted to our pediatric emergency department with a first episode of generalized tonic-clonic seizures after a short history of fever a week before admission. Seizures progressed rapidly into refractory status epilepticus without any evidence of the underlying cause, and treatment subsequently had to be escalated to thiopental anesthesia...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38505075/cerebral-protection-in-acute-type-a-aortic-dissection-surgery-a-systematic-review-and-meta-analysis
#23
JOURNAL ARTICLE
Mehran Rahimi, Hadi Sahrai, Ali Norouzi, Mohammadreza Taban-Sadeghi, Ahmadali Khalili, Sina Hamzehzadeh, Reza Ali Akbari Khoei, Hossein Hosseinifard, Ralf Martz Sulague, Jacques Kpodonu
BACKGROUND: Acute type A aortic dissection (ATAAD) still challenges physicians and warrants emergent surgical management. Two main methods to reduce cerebrovascular events in ATAAD surgeries are antegrade cerebral perfusion (ACP) and retrograde cerebral perfusion (RCP). We conducted a systematic review and meta-analysis to compare the outcomes of ACP and RCP methods during the ATAAD surgery. METHODS: In this study, we searched the databases until March 29th , 2023...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38502108/reproducibility-of-arterial-spin-labeling-cerebral-blood-flow-image-processing-a-report-of-the-ismrm-open-science-initiative-for-perfusion-imaging-osipi-_and-the-asl-mri-challenge
#24
JOURNAL ARTICLE
Andre M Paschoal, Joseph G Woods, Joana Pinto, Esther E Bron, Jan Petr, Flora A Kennedy McConnell, Laura Bell, Maria-Eleni Dounavi, Cassandra Gould van Praag, Henk J M M Mutsaerts, Aaron Oliver Taylor, Moss Y Zhao, Irène Brumer, Wei Siang Marcus Chan, Jack Toner, Jian Hu, Logan X Zhang, Catarina Domingos, Sara P Monteiro, Patrícia Figueiredo, Alexander G J Harms, Beatriz E Padrela, Channelle Tham, Ahmed Abdalle, Paula L Croal, Udunna Anazodo
PURPOSE: Arterial spin labeling (ASL) is a widely used contrast-free MRI method for assessing cerebral blood flow (CBF). Despite the generally adopted ASL acquisition guidelines, there is still wide variability in ASL analysis. We explored this variability through the ISMRM-OSIPI ASL-MRI Challenge, aiming to establish best practices for more reproducible ASL analysis. METHODS: Eight teams analyzed the challenge data, which included a high-resolution T1-weighted anatomical image and 10 pseudo-continuous ASL datasets simulated using a digital reference object to generate ground-truth CBF values in normal and pathological states...
March 19, 2024: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38501882/mri-hypoperfusion-as-a-determinant-of-cognitive-impairment-in-adults-with-moyamoya-angiopathy
#25
JOURNAL ARTICLE
Marine Giroud, Mélanie Planton, Jean Darcourt, Nicolas Raposo, Pierre Brandicourt, Hélène Mirabel, Dominique Hervé, Alain Viguier, Jean-François Albucher, Jérémie Pariente, Jean Marc Olivot, Fabrice Bonneville, Patrice Péran, Lionel Calviere
INTRODUCTION: In Moyamoya angiopathy (MMA), mechanisms underlying cognitive impairment remain debated. We aimed to assess the association of cognitive impairment with the degree and the topography of cerebral hypoperfusion in MMA. METHODS: A retrospective analysis of neuropsychological and perfusion MRI data from adults with MMA was performed. Ischemic and haemorrhagic lesion masks were created to account for cerebral lesions in the analysis of cerebral perfusion...
March 19, 2024: European Stroke Journal
https://read.qxmd.com/read/38501815/impact-of-cerebral-revascularization-on-pial-collateral-flow-in-patients-with-unilateral-moyamoya-disease-using-quantitative-magnetic-resonance-angiography
#26
JOURNAL ARTICLE
Brandon A Santhumayor, Timothy G White, Danielle Golub, Moses Rivera, Justin Turpin, David Golombeck, Brendan Ryu, Kevin Shah, Rafael Ortiz, Karen Black, Jeffrey M Katz, Amir R Dehdashti, David J Langer
BACKGROUND AND OBJECTIVES: Moyamoya disease (MMD) is a chronic steno-occlusive disease of the intracranial circulation that depends on neoangiogenesis of collateral vessels to maintain cerebral perfusion and is primarily managed with cerebral revascularization surgery. A quantitative assessment of preoperative and postoperative collateral flow using quantitative magnetic resonance angiography with noninvasive optimal vessel analysis (NOVA) was used to illustrate the impact of revascularization on cerebral flow distribution...
March 19, 2024: Neurosurgery
https://read.qxmd.com/read/38501716/beyond-the-final-heartbeat-neurological-perspectives-on-normothermic-regional-perfusion-for-organ-donation-after-circulatory-death
#27
REVIEW
Matthew P Kirschen, Ariane Lewis, Michael A Rubin, Panayiotis N Varelas, David M Greer
Normothermic regional perfusion (NRP) has recently been used to augment organ donation after circulatory death (DCD) to improve the quantity and quality of transplantable organs. In DCD-NRP, after withdrawal of life-sustaining therapies and cardiopulmonary arrest, patients are cannulated onto extracorporeal membrane oxygenation to reestablish blood flow to targeted organs including the heart. During this process, aortic arch vessels are ligated to restrict cerebral blood flow. We review ethical challenges including whether the brain is sufficiently reperfused through collateral circulation to allow reemergence of consciousness or pain perception, whether resumption of cardiac activity nullifies the patient's prior death determination, and whether specific authorization for DCD-NRP is required...
March 19, 2024: Annals of Neurology
https://read.qxmd.com/read/38499758/feasibility-of-assessing-non-invasive-intracranial-compliance-using-fsi-simulation-based-and-mr-elastography-based-brain-stiffness
#28
JOURNAL ARTICLE
Seifollah Gholampour
Intracranial compliance (ICC) refers to the change in intracranial volume per unit change in intracranial pressure (ICP). Magnetic resonance elastography (MRE) quantifies brain stiffness by measuring the shear modulus. Our objective is to investigate the relationship between ICC and brain stiffness through fluid-structure interaction (FSI) simulation, and to explore the feasibility of using MRE to assess ICC based on brain stiffness. This is invaluable due to the clinical importance of ICC, as well as the fast and non-invasive nature of the MRE procedure...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38498919/ruptured-pial-pial-collateral-aneurysm-associated-with-left-internal-carotid-artery-occlusion-nuances-of-surgical-management-illustrative-case
#29
JOURNAL ARTICLE
Juan Silvestre G Pascual, Eddie Guo, Runze Yang, Kristopher D Langdon, Sanju Lama, Garnette R Sutherland
BACKGROUND: Carotid occlusion often leads to the formation of a collateral network. On rare occasions, due to hemodynamic influence, aneurysms can occur. Here, the authors describe a 69-year-old male presenting with intracerebral hemorrhage secondary to a ruptured aneurysm within such a network. OBSERVATIONS: The patient presented to the emergency department with an altered level of consciousness. Imaging showed a left temporal lobe hemorrhage extending into the ventricle, subdural hematoma, and evidence of contrast extravasation...
March 18, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38497182/risk-factors-for-specific-postoperative-ischemic-complications-in-patients-with-moyamoya-disease-a-single-center-retrospective-study
#30
JOURNAL ARTICLE
Huan Zhu, Qihang Zhang, Wenjie Li, Peijiong Wang, Qian Zhang, Dong Zhang, Yan Zhang
AIM: To evaluate and compare postoperative ischemic complications to determine the risk factors for ischemic complications following revascularization surgery for Moyamoya disease (MMD). MATERIAL AND METHODS: This single-center retrospective study included 266 procedures between 2016 and 2021. Three types of revascularization approaches including direct bypass, indirect bypass, and combined bypass were performed. To identify risk factors for postoperative ischemic complications and contralateral cerebral infarction, preoperative clinical characteristics and radiographic features were examined using multivariate and ordinal logistic regression analyses...
2024: Turkish Neurosurgery
https://read.qxmd.com/read/38496517/high-resolution-multi-delay-arterial-spin-labeling-with-transformer-based-denoising-for-pediatric-perfusion-mri
#31
Qinyang Shou, Chenyang Zhao, Xingfeng Shao, Megan M Herting, Danny Jj Wang
Multi-delay arterial spin labeling (MDASL) can quantitatively measure cerebral blood flow (CBF) and arterial transit time (ATT), which is particularly suitable for pediatric perfusion imaging. Here we present a high resolution (iso-2mm) MDASL protocol and performed test-retest scans on 21 typically developing children aged 8 to 17 years. We further proposed a Transformer-based deep learning (DL) model with k-space weighted image average (KWIA) denoised images as reference for training the model. The performance of the model was evaluated by the SNR of perfusion images, as well as the SNR, bias and repeatability of the fitted CBF and ATT maps...
March 6, 2024: medRxiv
https://read.qxmd.com/read/38495722/measuring-pulsatile-cortical-blood-flow-and-volume-during-carotid-endarterectomy
#32
JOURNAL ARTICLE
Alexander I Zavriyev, Kutlu Kaya, Kuan Cheng Wu, Eric T Pierce, Maria Angela Franceschini, Mitchell B Robinson
Carotid endarterectomy (CEA) involves removal of plaque in the carotid artery to reduce the risk of stroke and improve cerebral perfusion. This study aimed to investigate the utility of assessing pulsatile blood volume and flow during CEA. Using a combined near-infrared spectroscopy/diffuse correlation spectroscopy instrument, pulsatile hemodynamics were assessed in 12 patients undergoing CEA. Alterations to pulsatile amplitude, pulse transit time, and beat morphology were observed in measurements ipsilateral to the surgical side...
March 1, 2024: Biomedical Optics Express
https://read.qxmd.com/read/38493187/beyond-the-microcirculation-sequestration-of-infected-red-blood-cells-and-reduced-flow-in-large-draining-veins-in-experimental-cerebral-malaria
#33
JOURNAL ARTICLE
A M Oelschlegel, R Bhattacharjee, P Wenk, K Harit, H-J Rothkötter, S P Koch, P Boehm-Sturm, K Matuschewski, E Budinger, D Schlüter, J Goldschmidt, G Nishanth
Sequestration of infected red blood cells (iRBCs) in the microcirculation is a hallmark of cerebral malaria (CM) in post-mortem human brains. It remains controversial how this might be linked to the different disease manifestations, in particular brain swelling leading to brain herniation and death. The main hypotheses focus on iRBC-triggered inflammation and mechanical obstruction of blood flow. Here, we test these hypotheses using murine models of experimental CM (ECM), SPECT-imaging of radiolabeled iRBCs and cerebral perfusion, MR-angiography, q-PCR, and immunohistochemistry...
March 16, 2024: Nature Communications
https://read.qxmd.com/read/38492021/evaluation-of-the-contribution-of-individual-arteries-to-the-cerebral-blood-supply-in-patients-with-moyamoya-angiopathy-comparison-of-vessel-encoded-arterial-spin-labeling-and-digital-subtraction-angiography
#34
JOURNAL ARTICLE
Leonie Zerweck, Rolf Pohmann, Uwe Klose, Petros Martirosian, Patrick Haas, Ulrike Ernemann, Nadia Khan, Constantin Roder, Till-Karsten Hauser, Florian Hennersdorf
PURPOSE: Vessel-encoded arterial spin labeling (VE-ASL) is able to provide noninvasive information about the contribution of individual arteries to the cerebral perfusion. The aim of this study was to compare VE-ASL to the diagnostic standard digital subtraction angiography (DSA) with respect to its ability to visualize vascular territories. METHODS: In total, 20 VE-ASL and DSA data sets of 17 patients with Moyamoya angiopathy with and without revascularization surgery were retrospectively analyzed...
March 16, 2024: Neuroradiology
https://read.qxmd.com/read/38491407/bilateral-vertebral-artery-injury-leads-to-brain-death-following-traumatic-brain-injury-a-case-report
#35
JOURNAL ARTICLE
Vera Irawany, Vizzi A F Nasution, Noorcahya Amalia
BACKGROUND: Vertebral artery injury is a rare condition in trauma settings. In the advanced stages, it causes death. CASE: A 31-year-old Sundanese woman with cerebral edema, C2-C3 anterolisthesis, and Le Fort III fracture after a motorcycle accident was admitted to the emergency room. On the fifth day, she underwent arch bar maxillomandibular application and debridement in general anesthesia with a hyperextended neck position. Unfortunately, her rigid neck collar was removed in the high care unit before surgery...
March 16, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38491167/ca-2-oscillation-in-vascular-smooth-muscle-cells-control-myogenic-spontaneous-vasomotion-and-counteract-post-ischemic-no-reflow
#36
JOURNAL ARTICLE
Jinze Li, Yiyi Zhang, Dongdong Zhang, Wentao Wang, Huiqi Xie, Jiayu Ruan, Yuxiao Jin, Tingbo Li, Xuzhao Li, Bingrui Zhao, Xiaoxuan Zhang, Jiayi Lin, Hongjun Shi, Jie-Min Jia
Ischemic stroke produces the highest adult disability. Despite successful recanalization, no-reflow, or the futile restoration of the cerebral perfusion after ischemia, is a major cause of brain lesion expansion. However, the vascular mechanism underlying this hypoperfusion is largely unknown, and no approach is available to actively promote optimal reperfusion to treat no-reflow. Here, by combining two-photon laser scanning microscopy (2PLSM) and a mouse middle cerebral arteriolar occlusion (MCAO) model, we find myogenic vasomotion deficits correlated with post-ischemic cerebral circulation interruptions and no-reflow...
March 15, 2024: Communications Biology
https://read.qxmd.com/read/38490814/effect-of-lower-body-negative-pressure-on-cardiac-and-cerebral-function-in-postural-orthostatic-tachycardia-syndrome-a-pilot-mri-assessment
#37
JOURNAL ARTICLE
Rachel J Skow, Stephen J Foulkes, Peter Seres, Meghan A Freer, Eric D Mathieu, Satish R Raj, Richard B Thompson, Mark H Haykowsky, Lawrence Richer
Postural orthostatic tachycardia syndrome (POTS) is characterized by an excessive heart rate (HR) response upon standing and symptoms indicative of inadequate cerebral perfusion. We tested the hypothesis that during lower body negative pressure (LBNP), individuals with POTS would have larger decreases in cardiac and cerebrovascular function measured using magnetic resonance (MR) imaging. Eleven patients with POTS and 10 healthy controls were studied at rest and during 20 min of -25 mmHg LBNP. Biventricular volumes, stroke volume (SV), cardiac output (Qc), and HR were determined by cardiac MR...
March 2024: Physiological Reports
https://read.qxmd.com/read/38489035/hemodynamic-impairments-of-evaluating-symptomatic-intracranial-atherosclerotic-stenosis-using-quantitative-flow-ratio-on-digital-subtraction-angiography-a%C3%A2-comparison-with-computed-tomography-perfusion-mri-and-fractional-flow-reserve
#38
JOURNAL ARTICLE
Yingchun Wu, Feng Gao, Honglin Feng
PURPOSE: Cerebral hemodynamics are important for the management of intracranial atherosclerotic stenosis (ICAS). The quantitative flow ratio (QFR) is a novel angiography-derived index for assessing the functional relevance of ICAS without pressure wires and adenosine. Good diagnostic yield with the hyperemic fractional flow reserve (FFR) have been reported, while data on the comparison of QFR to FFR are scarce. METHODS: In this prospective study 56 patients with anterior circulation symptomatic ICAS who received endovascular treatment were included...
March 15, 2024: Clinical Neuroradiology
https://read.qxmd.com/read/38488878/the-prediction-of-estimated-cerebral-perfusion-pressure-with-trans-systolic-time-in-preterm-and-term-infants
#39
JOURNAL ARTICLE
Masashi Zuiki, Mikito Ohta, Naoe Fujita, Daisuke Uda, Madoka Uesugi, Akio Yamano, Eisuke Ichise, Hidechika Morimoto, Kanae Hashiguchi, Daisuke Kinoshita, Tatsuji Hasegawa, Tomoko Iehara
It is important to monitor cerebral perfusion in infants because hypo- and hyperperfusion can contribute to neurological injury. This study aimed to clarify the relationship between trans-systolic time (TST) and critical closing pressure (CrCP) or estimated cerebral perfusion pressure (CPPe) in neonates. Moreover, we aimed to determine the TST values in preterm and term infants with stable cerebral perfusion to clarify normative reference data. This multicentre prospective study included infants with arterial lines admitted to the neonatal intensive care units between December 2021 and August 2023...
March 15, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38488357/ctp-defined-large-core-is-a-better-predictor-of-poor-outcome-for-endovascular-treatment-than-aspects-defined-large-core
#40
JOURNAL ARTICLE
Yi Sui, Wenhuo Chen, Chushuang Chen, Yanting Chang, Andrew Bivard, Peng Wang, Yu Geng, Mark Parsons, Longting Lin
BACKGROUND: Recent trials confirmed the effectiveness of endovascular therapy in patients with large ischemic cores. Yet the optimal neuroimaging modalities to define large core remains unclear. We tried to address this question by comparing the functional outcomes in patients receiving thrombectomy selected by either noncontrast computed tomography Alberta Stroke Program Early Computed Tomography Score (ASPECTS) or Computed Tomography perfusion (CTP). METHODS: This study retrospectively selected patients enrolled in the International Stroke Perfusion Registry between August 2011 and April 2022...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
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