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JOURNAL ARTICLE
Peter Gambell, Grant Rowley, Tracy Anh Thu Pham, Theresa Loan Dang, Huguette Mulumba, Larry Smith, Gabriella Lakos
INTRODUCTION: White blood cell (WBC) differential by flow cytometry can report a six-part WBC differential and enumerate blasts. Some modern hematology analyzers are also able to provide a six-part WBC differential (including immature granulocytes). Our goal was to compare the WBC differential obtained by the Abbott Alinity hq hematology analyzer to an 8-color single-tube flow cytometry method and to manual WBC differential. METHODS: Samples from 144 patients were tested with Alinity hq, flow cytometry, and microscopic WBC differential...
April 2022: International Journal of Laboratory Hematology
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JOURNAL ARTICLE
Huguette Simo Tchetgna, Francine Sado Yousseu, Basile Kamgang, Armel Tedjou, Philip J McCall, Charles S Wondji
Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using real time RT-PCR on fragments of the 5' and 3' UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria...
October 2021: PLoS Neglected Tropical Diseases
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JOURNAL ARTICLE
Johann Morelle, Céline Marechal, Zanzhe Yu, Huguette Debaix, Tanguy Corre, Mark Lambie, Marion Verduijn, Friedo Dekker, Philippe Bovy, Pieter Evenepoel, Bert Bammens, Rafael Selgas, Maria A Bajo, Annemieke M Coester, Amadou Sow, Nicolas Hautem, Dirk G Struijk, Raymond T Krediet, Jean-Luc Balligand, Eric Goffin, Ralph Crott, Pierre Ripoche, Simon Davies, Olivier Devuyst
BACKGROUND: Variability in ultrafiltration influences prescriptions and outcomes in patients with kidney failure who are treated with peritoneal dialysis. Variants in AQP1 , the gene that encodes the archetypal water channel aquaporin-1, may contribute to that variability. METHODS: We gathered clinical and genetic data from 1851 patients treated with peritoneal dialysis in seven cohorts to determine whether AQP1 variants were associated with peritoneal ultrafiltration and with a risk of the composite of death or technique failure (i...
October 21, 2021: New England Journal of Medicine
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JOURNAL ARTICLE
Fatiha Najioullah, Marie-José Dorival, Clarisse Joachim, Christiane Dispagne, Jonathan Macni, Sylvie Abel, Caroline Sulpicy, Huguette Charpentier-Baltide, Danièle Sainte-Rose, Béatrice Salomon-Frechou, Moustapha Dieye, Jacqueline Véronique-Baudin, Maurice Pré, Maurice Marquet, Gaëlle Wan-Ajouhu, Eustase Janky, Didier Riethmuller, Raymond Cesaire
The Caribbean ranks seventh among the world regions most affected by cervical cancer. HPV-prevalence and genotype distributions also differ from regions. Knowledge of HPV genotype profiles is important for patients care and HPV vaccination implementation. The objective of this study was to describe HPV genotype distribution and risk factors in a population-based cohort of women in Martinique. In this study, 1312 women were included and underwent cervical cancer screening with successful sample collection between 2009 and 2014...
2021: PloS One
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JOURNAL ARTICLE
Rasha Althiab-Almasaud, Huguette Sallanon, Caren Chang, Christian Chervin
The plant hormone ethylene plays vital roles in plant development, including pollen tube (PT) growth. Many studies have used the ethylene precursor, 1-aminocyclopropane-1-carboxylic acid (ACC), as a tool to trigger ethylene signaling. Several studies have suggested that ACC can act as a signal molecule independently of ethylene, inducing responses that are distinct from those induced by ethylene. In this study, we confirmed that ethylene receptor function is essential for promoting PT growth in tomato, but interestingly, we discovered that ACC itself can act as a signal that also promotes PT growth...
December 2021: Physiologia Plantarum
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JOURNAL ARTICLE
Stephanie Tchigui Manga Maffouo, Hippolyte Tene Mouafo, Raymond Simplice Mouokeu, Linda Manet, Alex Kamgain Tchuenchieu, Boris Noutsa Simo, Huguette Tchuitcheu Djeuachi, Gabriel Nama Medoua, François Tchoumbougnang
An investigation was performed to evaluate the braising fish practices and the level of hygiene of the sellers in the city of Yaoundé. Thereafter, five braised carp samples were collected from each of the five selected sites and their microbiological quality assessed. The results showed that all the braising sites do not satisfy the Good Hygiene and Manufacturing Practices. Pathogenic microorganisms such as coliforms (2.17 ± 0.08 to 5.94 ± 0.38 Log cfu/g), E. coli (3.71 ± 0.20 to 6.21 ± 0.48 Log cfu/g) and Salmonella spp...
August 2021: Heliyon
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JOURNAL ARTICLE
Nicolas Berthet, Stéphane Descorps-Declère, Camille Besombes, Manon Curaudeau, Andriniaina Andy Nkili Meyong, Benjamin Selekon, Ingrid Labouba, Ella Cyrielle Gonofio, Rita Sem Ouilibona, Huguette Dorine Simo Tchetgna, Maxence Feher, Arnaud Fontanet, Mirdad Kazanji, Jean-Claude Manuguerra, Alexandre Hassanin, Antoine Gessain, Emmanuel Nakoune
Monkeypox is an emerging infectious disease, which has a clinical presentation similar to smallpox. In the two past decades, Central Africa has seen an increase in the frequency of cases, with many monkeypox virus (MPXV) isolates detected in the Democratic Republic of Congo (DRC) and the Central African Republic (CAR). To date, no complete MPXV viral genome has been published from the human cases identified in the CAR. The objective of this study was to sequence the full genome of 10 MPXV isolates collected during the CAR epidemics between 2001 and 2018 in order to determine their phylogenetic relationships among MPXV lineages previously described in Central Africa and West Africa...
June 22, 2021: Scientific Reports
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JOURNAL ARTICLE
Ross William Boyle, Jordon Sandland, Sam Rimmer, Huguette Savoie
In this study, we present a convenient method for the labelling of tyrosine residues on Bovine Serum Albumin and Human Serum Albumin and report for the first time their subsequent bio-orthogonal conjugation with porphyrins via "click" chemistry. We demonstrate that these serum proteins can be labelled with an alkyne-diazonium heterobifunctional linker and can then undergo chemo-selective bio-orthogonal conjugation with a water-soluble azido metalloporphyrin via "click" chemistry to yield protein-conjugates that retain their photodynamic properties...
June 7, 2021: Chembiochem: a European Journal of Chemical Biology
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JOURNAL ARTICLE
Huguette Simo Tchetgna, Stephane Descorps-Declère, Benjamin Selekon, Aurelia Kwasiborski, Mathias Vandenbogaert, Jean-Claude Manuguerra, Antoine Gessain, Valérie Caro, Emmanuel Nakouné, Nicolas Berthet
Arenaviruses represent a family of viruses that are naturally present in rodents belonging to subfamily Murinae, Neotominae or Sigmodontinae. Except for Lassa virus, little information is available on other Old-World arenaviruses. Here, we describe strain AnRB3214, a virus isolated from a presumed Praomys sp. rodent in the Central African Republic in 1981 and assigned to Ippy virus based on antigenic similarity. The strain was simultaneously sequenced on Illumina NovaSeq 6000 and MinION Mk1B devices and analysed with various bioinformatics tools...
May 13, 2021: Scientific Reports
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JOURNAL ARTICLE
Gabriel Tchuente Kamsu, Dieudonné Pascal Djamen Chuisseu, Siméon Pierre Fodouop Chegaing, Huguette Bocanestine Laure Feudjio, Louis-Claire Ndel Famen, Norbert Kodjio, Jean Baptiste Sokoudjou, Donatien Gatsing
Tectona grandis ( T. grandis ) is a medicinal plant widely used in Cameroon to treat typhoid fever and several other diseases. Despite its heavy use for medical purposes, no study has yet been conducted to assess its potentially toxic effects. This study aimed at evaluating the acute and subchronic toxicological profile of Tectona grandis leaf extract in rats. The acute toxicity study revealed neither behavioral disturbances nor death in rats. The lethal dose (DL50 ) of this extract is greater than 5000 mg/kg body weight...
2021: Journal of Toxicology
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JOURNAL ARTICLE
Karl P Schlingmann, Aparna Renigunta, Ewout J Hoorn, Anna-Lena Forst, Vijay Renigunta, Velko Atanasov, Sinthura Mahendran, Tahsin Stefan Barakat, Valentine Gillion, Nathalie Godefroid, Alice S Brooks, Dorien Lugtenberg, Jennifer Lake, Huguette Debaix, Christoph Rudin, Bertrand Knebelmann, Stephanie Tellier, Caroline Rousset-Rouvière, Daan Viering, Jeroen H F de Baaij, Stefanie Weber, Oleg Palygin, Alexander Staruschenko, Robert Kleta, Pascal Houillier, Detlef Bockenhauer, Olivier Devuyst, Rosa Vargas-Poussou, Richard Warth, Anselm A Zdebik, Martin Konrad
BACKGROUND: The transepithelial transport of electrolytes, solutes, and water in the kidney is a well-orchestrated process involving numerous membrane transport systems. Basolateral potassium channels in tubular cells not only mediate potassium recycling for proper Na+ ,K+ -ATPase function but are also involved in potassium and pH sensing. Genetic defects in KCNJ10 cause EAST/SeSAME syndrome, characterized by renal salt wasting with hypokalemic alkalosis associated with epilepsy, ataxia, and sensorineural deafness...
June 1, 2021: Journal of the American Society of Nephrology: JASN
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JOURNAL ARTICLE
Calvin Didier Njiki, Thierry Ndzana Ndah, Germain H Ben Bolie, Jean Féli Beyala Ateba, Augustin Simo, Yolande Huguette Ebele Yigbedeck
Technical performances of two optically stimulated luminescence readers including, a microStar reader and an Auto 200 reader both manufactured by Landauer, Inc. were studied by the National Radiation Protection Agency Dosimetry Laboratory using manufacturer and International Electrotechnical Commission requirements. The two reader tools demonstrated satisfactory results as they met all the requirements. The two readers showed similar performance for the overall uncertainty and the Coefficient of Variation tests...
March 16, 2021: Radiation Protection Dosimetry
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JOURNAL ARTICLE
Jean-Louis Guéant, Rosa-Maria Guéant-Rodriguez, Julien Fromonot, Abderrahim Oussalah, Huguette Louis, Celine Chery, Mickael Gette, Stanislas Gleye, Jonas Callet, Jeremie Raso, François Blanchecotte, Patrick Lacolley, Régis Guieu, Véronique Regnault
BACKGROUND: Many arguments suggest that neutrophils could play a prominent role in COVID-19. However, the role of key components of neutrophil innate immunity in severe forms of COVID-19 has deserved insufficient attention. We aimed to evaluate the involvement of Neutrophil Elastase, histone-DNA, and DNases in systemic and multi-organ manifestations of COVID-19. METHODS: We performed a multicenter study of markers of neutrophil innate immunity in 155 cases consecutively recruited in a screening center, local hospitals, and two regional university hospitals...
January 23, 2021: Allergy
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JOURNAL ARTICLE
Yolaine Glèlè-Ahanhanzo, Alphonse Kpozèhouen, Charles Sossa-Jerôme, Ghislain E Sopoh, Huguette Tedji, Koovy Yete, Alain Levêque
BACKGROUND: The implementation of road safety interventions in many developing countries usually focuses on the behavior of users. In order to draw more attention on the role of road infrastructure and physical environment in road safety interventions, this study aims to analyze the environmental and road factors associated with the pedestrians involved in traffic crashes in Benin. METHOD: The method used was an analysis of national road crash statistics for the period 2008 to 2015...
January 19, 2021: BMC Public Health
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JOURNAL ARTICLE
Caroline Matis, Dominique Ducloux, Aude Ougier-Bouilloux, Huguette Guisado
No abstract text is available yet for this article.
October 21, 2020: Revue Médicale Suisse
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JOURNAL ARTICLE
Virginie Montiel, Ramona Bella, Lauriane Y M Michel, Hrag Esfahani, Delphine De Mulder, Emma L Robinson, Jean-Philippe Deglasse, Malte Tiburcy, Pak Hin Chow, Jean-Christophe Jonas, Patrick Gilon, Benjamin Steinhorn, Thomas Michel, Christophe Beauloye, Luc Bertrand, Charlotte Farah, Flavia Dei Zotti, Huguette Debaix, Caroline Bouzin, Davide Brusa, Sandrine Horman, Jean-Louis Vanoverschelde, Olaf Bergmann, Dimitri Gilis, Marianne Rooman, Alessandra Ghigo, Simonetta Geninatti-Crich, Andrea Yool, Wolfram H Zimmermann, H Llewelyn Roderick, Olivier Devuyst, Jean-Luc Balligand
Pathological remodeling of the myocardium has long been known to involve oxidant signaling, but strategies using systemic antioxidants have generally failed to prevent it. We sought to identify key regulators of oxidant-mediated cardiac hypertrophy amenable to targeted pharmacological therapy. Specific isoforms of the aquaporin water channels have been implicated in oxidant sensing, but their role in heart muscle is unknown. RNA sequencing from human cardiac myocytes revealed that the archetypal AQP1 is a major isoform...
October 7, 2020: Science Translational Medicine
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JOURNAL ARTICLE
Arielle Lasry, Nathalie K Danho, Erin N Hulland, Annie D Diokouri, Marie-Huguette Kingbo, Nicole I L Doumatey, Alexandre K Ekra, Laurence G Ebah, Hoba Kouamé, Judith Hedje, Anne-Eudes Jean-Baptiste
In Côte d'Ivoire, the Family Approach to Counseling and Testing (FACT) program began in 2015 and provides facility-based HIV testing to the sexual partners, children and other household family members of HIV-positive index cases. We evaluated whether the FACT program is an effective approach to HIV case finding. We reviewed 1762 index patient charts to evaluate outcomes of the FACT program, held across 36 facilities in Abidjan. Index cases enumerated a total of 644 partners, 2301 children and 508 other family members including parents and siblings...
September 1, 2020: AIDS and Behavior
#38
JOURNAL ARTICLE
Steven Y Yap, Huguette Savoie, Isaline Renard, Benjamin P Burke, Harry C Sample, Saul Michue-Seijas, Stephen J Archibald, Ross W Boyle, Graeme J Stasiuk
The goal of "personalised" medicine has seen a growing interest in the development of theranostic agents. Bifunctional, and targeted-trifunctional, theranostic water-soluble porphyrins with a histidine-like chelating group have been synthesised via copper-catalysed azide-alkyne cycloaddition (CuAAC) "click" chemistry in high yield and purity. They are capable of photodynamic treatment and [99mTc(CO)3]+ complexation for single-photon emission computed tomography (SPECT) imaging, with a radiochemical yield of >95%...
August 19, 2020: Chemical Communications: Chem Comm
#39
JOURNAL ARTICLE
Pierre-Antoine Juge, Joyce S Lee, Jessica Lau, Leticia Kawano-Dourado, Jorge Rojas Serrano, Marco Sebastiani, Gouri Koduri, Eric Matteson, Karina Bonfiglioli, Marcio Sawamura, Ronaldo Kairalla, Lorenzo Cavagna, Emanuele Bozzalla Cassione, Andreina Manfredi, Mayra Mejia, Pedro Rodríguez-Henriquez, Montserrat I González-Pérez, Ramcés Falfán-Valencia, Ivette Buendia-Roldán, Gloria Pérez-Rubio, Esther Ebstein, Steven Gazal, Raphaël Borie, Sébastien Ottaviani, Caroline Kannengiesser, Benoît Wallaert, Yurdagul Uzunhan, Hilario Nunes, Dominique Valeyre, Nathalie Saidenberg-Kermanac'h, Marie-Christophe Boissier, Lidwine Wemeau-Stervinou, René-Marc Flipo, Sylvain Marchand-Adam, Pascal Richette, Yannick Allanore, Claire Dromer, Marie-Elise Truchetet, Christophe Richez, Thierry Schaeverbeke, Huguette Lioté, Gabriel Thabut, Kevin D Deane, Joshua J Solomon, Tracy Doyle, Jay H Ryu, Ivan Rosas, V Michael Holers, Catherine Boileau, Marie-Pierre Debray, Raphaël Porcher, David A Schwartz, Robert Vassallo, Bruno Crestani, Philippe Dieudé
QUESTION ADDRESSED BY THE STUDY: Methotrexate (MTX) is a key anchor drug for rheumatoid arthritis (RA) management. Fibrotic interstitial lung disease (ILD) is a common complication of RA. Whether MTX exposure increases the risk of ILD in patients with RA is disputed. We aimed to evaluate the association of prior MTX use with development of RA-ILD. METHODS: Through a case-control study design with discovery and international replication samples, we examined the association of MTX exposure with ILD in 410 patients with chronic fibrotic ILD associated with RA (RA-ILD) and 673 patients with RA without ILD...
February 2021: European Respiratory Journal
#40
JOURNAL ARTICLE
Jasper Deckers, Tom Cardeynaels, Huguette Penxten, Anitha Ethirajan, Marcel Ameloot, Mikalai Kruk, Benoît Champagne, Wouter Maes
Boron dipyrromethene (BODIPY) dyes represent a particular class within the broad array of potential photosensitizers. Their highly fluorescent nature opens the door for theragnostic applications, combining imaging and therapy using a single, easily synthesized chromophore. However, near-infrared absorption is strongly desired for photodynamic therapy to enhance tissue penetration. Furthermore, singlet oxygen should preferentially be generated without the incorporation of heavy atoms, as these often require additional synthetic efforts and/or afford dark cytotoxicity...
June 25, 2020: Chemistry: a European Journal
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