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Sabine Montaut, Gina R De Nicola, Huguette Agnaniet, Yves Issembe, Patrick Rollin, Chantal Menut
Drypetes euryodes (Hiern) Hutch., Drypetes gossweileri S. Moore, Drypetes laciniata Hutch. (Putranjivaceae), Rinorea subintegrifolia O. Ktze, and Rinorea woermanniana (Büttner) Engl. (Violaceae) from Gabon were probed for the presence of glucosinolates (GLs). When present, the GLs were identified and quantified by HPLC analysis. 2-Hydroxy-2-methyl GL (1) was the major GL in the cork of D. euryodes. Moreover, 4-hydroxybenzyl GL (2) was the major GL in the seed of D. gossweileri whereas the bark contained 2 as the minor GL and benzyl GL (3) was the major one...
February 2017: Natural Product Research
Huguette Nguedie Tchouanguem, Florent Ymele Fouelifack, Basile Keugoung, Loic Dongmo Fouelifa, Roger Somo Moyou
INTRODUCTION: Schistosomiasis, the second endemic parasitic infection in the world, is a parasitosis caused by trematodes from the genus Schistosoma. Our study aims to assess the prevalence of different species of schistosomes (Schistosoma mansoni, haematobium and intercalatum) among schoolchildren and to identify risk factors, clinical signs of schistosomiasis, and schistosomiasis intermediate host snails in stagnant water. METHODS: We conducted a cross sectional study over a three months period...
2016: Pan African Medical Journal
Laura J Broughton, Francesca Giuntini, Huguette Savoie, Francesca Bryden, Ross W Boyle, Anthony Maraveyas, Leigh A Madden
Duramycin, through binding with phosphatidylethanolamine (PE), has been shown to be a selective molecular probe for the targeting and imaging of cancer cells. Photodynamic therapy aims to bring about specific cytotoxic damage to tumours through delivery of a photosensitising agent and light irradiation. Conjugation to biological molecules that specifically target cancer has been shown to increase photosensitiser (PS) selectivity and decrease damage to surrounding normal tissue. The aim of this study was to target tumour cells with a PE-specific PS therefore duramycin was conjugated to a porphyrin based PS which was achieved via direct reaction with the ε-amino group on the lysine residue near duramycin's N-terminal...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
Huguette S Brink, Aart Jan van der Lely, Joke van der Linden
Gestational diabetes (GD) is a frequent complication during pregnancy and is associated with maternal and neonatal complications. It is suggested that a disturbing environment for the foetus, such as impaired glucose metabolism during intrauterine life, may result in enduring epigenetic changes leading to increased disease risk in adult life. Hence, early prediction of GD is vital. Current risk prediction models are based on maternal and clinical parameters, lacking a strong predictive value. Adipokines are mainly produced by adipocytes and suggested to be a link between obesity and its cardiovascular complications...
September 2016: Endocrine Connections
Fabrice Vanhuyse, Nicolas Ducrocq, Huguette Louis, Narimane Al Kattani, Nicolas Laurent, Frédérique Joineau-Groubatch, Aude Falanga, Juan-Pablo Maureira, Antoine Kimmoun, Nicolas Girerd, Nguyen Tran, Bruno Levy
Cardiogenic shock (CS) patients treated with ECMO have severe cardiac failure, associated with ischemia-reperfusion. The use of moderate hypothermia during ischemia-reperfusion syndrome is supported by experimental data. We therefore studied the effects of moderate hypothermia on cardiac and vascular function in pig ischemic CS treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO).Cardiogenic shock was induced in 12 anesthetized pigs by coronary ligation. After one hour of CS, VA-ECMO was initiated and pigs were randomized to normothermia (38°C) or moderate hypothermia (34°C) during 8 hours...
August 2, 2016: Shock
Joanna Spinato, Élyse Boivin, Émilie Bélanger-Trudelle, Huguette Fauchon, Cécile Tremblay, Hafid Soualhine
BACKGROUND: The increasing emergence of drug-resistant tuberculosis presents a threat to the effective control of tuberculosis (TB). Rapid detection of drug-resistance is more important than ever to address this scourge. The purpose of this study was to genotypically characterize the first-line antitubercular drug-resistant isolates collected over 11 years in Quebec. RESULTS: The main mutations found in our resistant strains collection (n = 225) include: the S315T substitution in katG (50...
2016: BMC Microbiology
Huguette Gaelle Ngassa Mbenda, Aparup Das
Understanding the population genetics of genes which shape resistance to antimalarial drugs can help in devising novel control strategies. The high spread of the resistant strains of the malaria parasite Plasmodium falciparum pose a greater challenge than before to the control programs across the world. Specific mutations in the P. falciparum chloroquine resistant transporter gene "Pfcrt" have been associated with resistance to not only chloroquine, but also to amodiaquine, one of the artemisinin partners used in Cameroon for the treatment of uncomplicated malaria...
October 2016: Infection, Genetics and Evolution
Huguette Turgeon O'Brien, Rosanne Blanchet, Doris Gagné, Julie Lauzière, Carole Vézina
The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs. Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive protein (CRP) level and (2) SF < 15 or <50 μg/L with CRP ≤ 5 or >5 mg/L, respectively. IDE corresponded to iron depletion combined with total iron binding capacity > 72 μmol/L and/or transferrin saturation < 16%...
2016: Anemia
Huguette Gaelle Ngassa Mbenda, Inocent Gouado, Aparup Das
No abstract text is available yet for this article.
2016: Journal of Infection in Developing Countries
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Oscar Pacheco, Mauricio Beltrán, Christina A Nelson, Diana Valencia, Natalia Tolosa, Sherry L Farr, Ana V Padilla, Van T Tong, Esther L Cuevas, Andrés Espinosa-Bode, Lissethe Pardo, Angélica Rico, Jennita Reefhuis, Maritza González, Marcela Mercado, Pablo Chaparro, Mancel Martínez Duran, Carol Y Rao, María M Muñoz, Ann M Powers, Claudia Cuéllar, Rita Helfand, Claudia Huguett, Denise J Jamieson, Margaret A Honein, Martha L Ospina Martínez
Background Colombia began official surveillance for Zika virus disease (ZVD) in August 2015. In October 2015, an outbreak of ZVD was declared after laboratory-confirmed disease was identified in nine patients. Methods Using the national population-based surveillance system, we assessed patients with clinical symptoms of ZVD from August 9, 2015, to April 2, 2016. Laboratory test results and pregnancy outcomes were evaluated for a subgroup of pregnant women. Concurrently, we investigated reports of microcephaly for evidence of congenital ZVD...
June 15, 2016: New England Journal of Medicine
Christian Schmied, Albina Nowak, Christiane Gruner, Eric Olinger, Huguette Debaix, Andreas Brauchlin, Michelle Frank, Saskia Reidt, Pierre Monney, Frédéric Barbey, Dipen Shah, Mehdi Namdar
OBJECTIVE: Best treatment outcomes in Fabry disease (FD) associated cardiomyopathy can be obtained when treatment is started as early as possible. The rationale of this study was to assess the role of ECG changes for identification of cardiac involvement and patients at an earlier stage of the disease more likely deriving a benefit from enzyme replacement therapy (ERT). METHODS: A retrospective analysis of patient data was performed from an observational, longitudinal, prospective cohort...
August 15, 2016: Heart: Official Journal of the British Cardiac Society
Chaojie Wei, Narimane Al Kattani, Huguette Louis, Eliane Albuisson, Bruno Levy, Antoine Kimmoun
OBJECTIVE: Previous studies have suggested that lowering heart rate (HR) by selective β1-blockers improves sepsis-induced cardiac and vascular dysfunction primarily by decreasing proinflammatory pathways. However, the impact of isolated heart rate reduction (HRR) on hemodynamics and inflammatory pathways remains unknown. The present study was designed to assess the effects of HRR by ivabradine, an If channel inhibitor, on cardiovascular function and inflammatory pathways in peritonitis-induced septic shock in rats...
September 2016: Shock
Huguette Agnaniet, Elvis Jolinom Mbot, Ousmane Keita, Jean-Alain Fehrentz, Anita Ankli, Audrey Gallud, Marcel Garcia, Magali Gary-Bobo, Jacques Lebibi, Thierry Cresteil, Chantal Menut
BACKGROUND: Diabetes mellitus is a metabolic disorder which is rising globally in rich and developing countries. In the African region this rate is the highest, with 20 million diagnosed diabetics. Despite a noticeable progress in the treatment of diabetes mellitus by synthetic drugs, the search for new natural anti-diabetic agents is going on. Nauclea diderrichii (De Wild.) Merr. (ND) and Sarcocephalus pobeguinii Hua ex Pellegr. (SP) are used as traditional medicines in Gabon for the treatment of different diseases, especially in the case of diabetes...
2016: BMC Complementary and Alternative Medicine
(no author information available yet)
CLEAR AND accessible, this guide does exactly what it says on the cover. After providing a guided tour of the basics of research, the authors explain how to identify research problems and shape the question behind them.
February 2016: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
Bertrand Hugo Mbatchou Ngahane, Huguette Atangana Ekobo, Christopher Kuaban
BACKGROUND: Tobacco is the most important avoidable risk for non communicable diseases. While tobacco consumption is stable or declining in developed countries, it is increasing in the developing world with a rate of 3.4 % per annum. The objective of this study was to estimate the prevalence and factors associated with cigarette smoking among college students. METHODS: A cross-sectional study was conducted from December 2012 to April 2013 in secondary schools in Douala, Cameroon...
2015: Archives of Public Health, Archives Belges de Santé Publique
Guy M Entract, Francesca Bryden, Juozas Domarkas, Huguette Savoie, Louis Allott, Stephen J Archibald, Chris Cawthorne, Ross W Boyle
Synthesis of the first water-soluble porphyrin radiolabeled with fluorine-18 is described: a new molecular theranostic agent which integrates the therapeutic selectivity of photodynamic therapy (PDT) with the imaging efficacy of positron emission tomography (PET). Generation of the theranostic was carried out through the conjugation of a cationic water-soluble porphyrin bearing an azide functionality to a fluorine-18 radiolabeled prosthetic bearing an alkyne functionality through click conjugation, with excellent yields obtained in both cold and hot synthesis...
December 7, 2015: Molecular Pharmaceutics
Huguette Young
No abstract text is available yet for this article.
December 8, 2015: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Reine El Omar, Yu Xiong, Gabriel Dostert, Huguette Louis, Monique Gentils, Patrick Menu, Jean-François Stoltz, Émilie Velot, Véronique Decot
Wharton's jelly mesenchymal stromal cells (WJ-MSCs) are promising candidates for tissue engineering, as their immunomodulatory activity allows them to escape immune recognition and to suppress several immune cell functions. To date, however, few studies have investigated the effect of differentiation of the MSCs on this immunomodulation. To address this question, we sought to determine the impact of differentiation toward endothelial cells on immunoregulation by WJ-MSCs. Following differentiation, the endothelial-like cells (ELCs) were positive for CD31, vascular endothelial cadherin and vascular endothelial growth factor receptor 2, and able to take up acetylated low-density lipoproteins...
April 2016: Immunology and Cell Biology
(no author information available yet)
This is a guide that does what it says on the cover. The writing is accessible and each chapter starts with clear aims and finishes with learning points, offering activities for nursing and midwifery students to practise.
October 28, 2015: Nursing Standard
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