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https://www.readbyqxmd.com/read/28868558/delayed-release-singlet-oxygen-sensitizers-based-on-pyridone-appended-porphyrins
#1
Susan Callaghan, Mikhail A Filatov, Elisabeth Sitte, Huguette Savoie, Ross W Boyle, Keith J Flanagan, Mathias O Senge
A new type of porphyrin photosensitizer capable of generating singlet oxygen upon irradiation, storing it through binding to pyridone subunits, followed by slow release at 20-40 °C, is reported. The timescale of singlet oxygen release can be varied depending on the pyridone group substitution pattern, forming endoperoxides of different stabilities. Modified tetra- and octa-substituted pyridone-porphyrins showed solubility in water, allowing for straightforward delivery into cells. The effect of delayed singlet oxygen formation due to endoperoxide decomposition was demonstrated on cancer cells in vitro...
September 13, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28636039/a-convenient-method-for-multicolour-labelling-of-proteins-with-bodipy-fluorophores-via-tyrosine-residues
#2
Miffy H Y Cheng, Huguette Savoie, Francesca Bryden, Ross W Boyle
Fluorescence is an essential imaging modality for labelling and visualising cells and sub-cellular structures. Multicolour labelling is especially challenging due to differences in physicochemical and photophysical behaviour of structurally unrelated fluorophores in the heterogeneous environments found in sub-cellular compartments. Herein, we report the conjugation of three azide-bearing BODIPYs with similar core structures but widely different emission wavelengths (green, red and NIR) to tyrosine residues of a model globular protein (BSA) via a common linking methodology...
August 9, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28579553/new-sesquiterpene-acid-and-inositol-derivatives-from-inula-montana-l
#3
Elnur Garayev, Gaëtan Herbette, Carole Di Giorgio, Philippe Chiffolleau, David Roux, Huguette Sallanon, Evelyne Ollivier, Riad Elias, Béatrice Baghdikian
A phytochemical investigation of the ethanol extract of leaves and flowers of Inula montana L. led to the isolation of one new sesquiterpene acid called Eldarin (1) and four new inositol derivatives, Myoinositol,1,5-diangelate-4,6-diacetate (2), Myoinositol,1,6-diangelate-4,5-diacetate (3), Myoinositol-1-angelate-4,5-diacetate-6-(2-methylbutirate) (4), Myoinositol-1-angelate-4,5-diacetate-6-isovalerate (5) isolated for the first time, along with eleven known compounds described for the first time in Inula montana, 1β-Hydroxyarbusculin A (6), Artemorin (7), Santamarin (8), Chrysosplenol C (9), 6-Hydroxykaempferol 3,7-dimethyl ether (10), Reynosin (11), Calenduladiol-3-palmitate (12), Costunolide (13), 4-Hydroxy-3,5-dimethoxybenzenemethanol (14), 9β-Hydroxycostunolide (15) and Hispidulin (16)...
July 2017: Fitoterapia
https://www.readbyqxmd.com/read/28560631/genetics-of-hiv-associated-sensory-neuropathy-and-related-pain-in-africans
#4
REVIEW
Huguette Gaelle Ngassa Mbenda, Antonia Wadley, Zane Lombard, Catherine Cherry, Patricia Price, Peter Kamerman
Despite the use of safer antiretroviral medications, the rate of HIV-associated sensory neuropathy (HIV-SN), the most common neurological complication of HIV, remains high. This condition is often painful and has a negative effect on quality of life. Up to 90% of those with HIV-SN experience pain for which there is no effective analgesic treatment. Genetic factors are implicated, but there is a lack of a comprehensive body of research for African populations. This knowledge gap is even more pertinent as Africans are most affected by HIV...
May 30, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28495692/shared-genetic-predisposition-in-rheumatoid-arthritis-interstitial-lung-disease-and-familial-pulmonary-fibrosis
#5
Pierre-Antoine Juge, Raphaël Borie, Caroline Kannengiesser, Steven Gazal, Patrick Revy, Lidwine Wemeau-Stervinou, Marie-Pierre Debray, Sébastien Ottaviani, Sylvain Marchand-Adam, Nadia Nathan, Gabriel Thabut, Christophe Richez, Hilario Nunes, Isabelle Callebaut, Aurélien Justet, Nicolas Leulliot, Amélie Bonnefond, David Salgado, Pascal Richette, Jean-Pierre Desvignes, Huguette Lioté, Philippe Froguel, Yannick Allanore, Olivier Sand, Claire Dromer, René-Marc Flipo, Annick Clément, Christophe Béroud, Jean Sibilia, Baptiste Coustet, Vincent Cottin, Marie-Christophe Boissier, Benoit Wallaert, Thierry Schaeverbeke, Florence Dastot le Moal, Aline Frazier, Christelle Ménard, Martin Soubrier, Nathalie Saidenberg, Dominique Valeyre, Serge Amselem, Catherine Boileau, Bruno Crestani, Philippe Dieudé
Despite its high prevalence and mortality, little is known about the pathogenesis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Given that familial pulmonary fibrosis (FPF) and RA-ILD frequently share the usual pattern of interstitial pneumonia and common environmental risk factors, we hypothesised that the two diseases might share additional risk factors, including FPF-linked genes. Our aim was to identify coding mutations of FPF-risk genes associated with RA-ILD.We used whole exome sequencing (WES), followed by restricted analysis of a discrete number of FPF-linked genes and performed a burden test to assess the excess number of mutations in RA-ILD patients compared to controls...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28407710/generation-of-triplet-excited-states-via-photoinduced-electron-transfer-in-meso-anthra-bodipy-fluorogenic-response-toward-singlet-oxygen-in-solution-and-in-vitro
#6
Mikhail A Filatov, Safakath Karuthedath, Pavel M Polestshuk, Huguette Savoie, Keith J Flanagan, Cindy Sy, Elisabeth Sitte, Maxime Telitchko, Frédéric Laquai, Ross W Boyle, Mathias O Senge
Heavy atom-free BODIPY-anthracene dyads (BADs) generate locally excited triplet states by way of photoinduced electron transfer (PeT), followed by recombination of the resulting charge-separated states (CSS). Subsequent quenching of the triplet states by molecular oxygen produces singlet oxygen ((1)O2), which reacts with the anthracene moiety yielding highly fluorescent species. The steric demand of the alkyl substituents in the BODIPY subunit defines the site of (1)O2 addition. Novel bis- and tetraepoxides and bicyclic acetal products, arising from rearrangements of anthracene endoperoxides were isolated and characterized...
May 1, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28372562/aqueous-extract-of-peperomia-pellucida-l-hbk-accelerates-fracture-healing-in-wistar-rats
#7
Ngueguim Tsofack Florence, Sakouong Talle Suewellyne Huguette, Donfack Jean Hubert, Gounoue Kamkumo Raceline, Dzeufiet Djomeni Paul Desire, Kamtchouing Pierre, Dimo Theophile
BACKGROUND: Peperomia pellucida (L.) HBK is consumed as vegetable and used in Cameroonian traditional medicine for the management of diseases and for fracture healing. Therefore the aim of this study was to evaluate the effects of the aqueous whole plant extract of Peperomia pellucida on fracture healing in female Wistar rats. METHODS: A drill hole injury was created by inserting a drill bit inthe diaphysis of the femur. The aqueous extract of the whole plant of Peperomia pellucida was administered orally at the doses of 100, 200 and 400 mg/kg to adult female Wistar rats...
April 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28350284/molecular-characterization-of-the-kamese-virus-an-unassigned-rhabdovirus-isolated-from-culex-pruina-in-the-central-african-republic
#8
Huguette Dorine Simo Tchetgna, Emmanuel Nakoune, Benjamin Selekon, Antoine Gessain, Jean-Claude Manuguerra, Mirdad Kazanji, Nicolas Berthet
Rhabdoviridae is one of the most diversified families of RNA viruses whose members infect a wide range of plants, animals, and arthropods. The members of this family are classified into 13 genera and >150 unassigned viruses. Here, we sequenced the complete genome of a rhabdovirus belonging to the Hart Park serogroup, the Kamese virus (KAMV), isolated in 1977 from Culex pruina in the Central African Republic. The genomic sequence showed an organization typical of rhabdoviruses with additional genes in the P-M and G-L intergenic regions, as already reported for the Hart Park serogroup...
June 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28151569/nanososg-a-nanostructured-fluorescent-probe-for-the-detection-of-intracellular-singlet-oxygen
#9
Rubén Ruiz-González, Roger Bresolí-Obach, Òscar Gulías, Montserrat Agut, Huguette Savoie, Ross W Boyle, Santi Nonell, Francesca Giuntini
A biocompatible fluorescent nanoprobe for singlet oxygen ((1) O2 ) detection in biological systems was designed, synthesized, and characterized, that circumvents many of the limitations of the molecular probe Singlet Oxygen Sensor Green(®) (SOSG). This widely used commercial singlet oxygen probe was covalently linked to a polyacrylamide nanoparticle core using different architectures to optimize the response to (1) O2 . In contrast to its molecular counterpart, the optimum SOSG-based nanoprobe, which we call NanoSOSG, is readily internalized by E...
February 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28143656/bone-marrow-transplantation-improves-proximal-tubule-dysfunction-in-a-mouse-model-of-dent-disease
#10
Sarah S Gabriel, Hendrica Belge, Alkaly Gassama, Huguette Debaix, Alessandro Luciani, Thomas Fehr, Olivier Devuyst
Dent disease is a rare X-linked tubulopathy caused by mutations in the endosomal chloride-proton exchanger (ClC-5) resulting in defective receptor-mediated endocytosis and severe proximal tubule dysfunction. Bone marrow transplantation has recently been shown to preserve kidney function in cystinosis, a lysosomal storage disease causing proximal tubule dysfunction. Here we test the effects of bone marrow transplantation in Clcn5(Y/-) mice, a faithful model for Dent disease. Transplantation of wild-type bone marrow in Clcn5(Y/-) mice significantly improved proximal tubule dysfunction, with decreased low-molecular-weight proteinuria, glycosuria, calciuria, and polyuria four months after transplantation, compared to Clcn5(Y/-) mice transplanted with ClC-5 knockout bone marrow...
January 28, 2017: Kidney International
https://www.readbyqxmd.com/read/28074415/proceedings-of-r%C3%A3-animation-2017-the-french-intensive-care-society-international-congress
#11
Wulfran Bougouin, Eloi Marijon, Benjamin Planquette, Nicole Karam, Florence Dumas, David Celermajer, Daniel Jost, Lionel Lamhaut, Frankie Beganton, Alain Cariou, Guy Meyer, Xavier Jouven, Côme Bureau, Julien Charpentier, Omar Ben Hadj Salem, Lucie Guillemet, Michel Arnaout, Alexis Ferre, Guillaume Geri, Nicolas Mongardon, Frédéric Pène, Jean-Daniel Chiche, Jean-Paul Mira, Guylaine Labro, François Belon, Vinh-Phuc Luu, Julien Chenet, Guillaume Besch, Marc Puyraveau, Gaël Piton, Gilles Capellier, Maëlle Martin, Jean-Baptiste Lascarrou, Aurélie Le Thuaut, Jean-Claude Lacherade, Laurent Martin-Lefèvre, Maud Fiancette, Isabelle Vinatier, Christine Lebert, Konstantinos Bachoumas, Aihem Yehia, Matthieu Henry-Laguarrigue, Gwenhaël Colin, Jean Reignier, Elodie Privat, Joséphine Escutnaire, Cyrielle Dumont, Valentine Baert, Christian Vilhelm, Hervé Hubert, Vincent Robert-Edan, Karim Lakhal, Andrew Quartin, Brian Hobbs, Cynthia Cely, Cynthia Bell, Tai Pham, Roland Schein, Yimin Geng, Chaan Ng, Stephan Ehrmann, Charlotte Salmon Gandonnière, Julie Boisramé-Helms, Olivier Le Tilly, Isabelle Benz De Bretagne, Emmanuelle Mercier, Julie Mankikian, Anne Bretagnol, Ferhat Meziani, Jean Michel Halimi, Chantal Barin Le Guellec, Stéphane Gaudry, David Hajage, Florence Tubach, Bertrand Pons, Eric Boulet, Alexandre Boyer, Guillaume Chevrel, Nicolas Lerolle, Dorothée Carpentier, Nicolas de Prost, Alexandre Lautrette, Julien Mayaux, Saad Nseir, Jean-Damien Ricard, Didier Dreyfuss, René Robert, Franscesco Garzotto, Eric Kipnis, Ciro Tetta, Claudio Ronco, David Schnell, Bourmaud Aurelie, Marie Reynaud, Christophe Clec'h, Mourad Benyamina, François Vincent, Christophe Mariat, Caroline Bornstain, Stephane Rouleau, Christophe Leroy, Yves Cohen, Jerome Morel, Matthieu Legrand, Jeremy Terreaux, Michaël Darmon, Marie Cantier, Adeline Morisot, Emmanuel Guérot, Emmanuel Canet, Etienne De Montmollin, Guillaume Voiriot, Mathilde Neuville, Jean-François Timsit, Romain Sonneville, Abdallah Fayssoil, Tania Stojkovic, Anthony Behin, Adam Ogna, Frédéric Lofaso, Pascal Laforet, Karim Wahbi, Helene Prigent, Denis Duboc, David Orlikowski, Bruno Eymard, Djillali Annane, Loic Le Guennec, Clémentine Cholet, Nicolas Bréchot, Guillaume Hekimian, Sébastien Besset, Guillaume Lebreton, Ania Nieszkowska, Jean Louis Trouillet, Pascal Leprince, Alain Combes, Charles-Edouard Luyt, Marion Griton, Musa Sesay, Nadia Sibaï De Panthou, Thomas Bienvenu, Matthieu Biais, Karine Nouette-Gaulain, Guillaume Fossat, Florian Baudin, Cécile Coulanges, Sabrine Bobet, Arnaud Dupont, Léa Courtes, Dalila Benzekri, Toufik Kamel, Grégoire Muller, Nicolas Bercault, François Barbier, Isabelle Runge, Marie Skarzynski, Armelle Mathonnet, Thierry Boulain, Youenn Jouan, Noémie Teixera, Claire Hassen-Khodja, Antoine Guillon, Christophe Gaborit, Leslie Grammatico-Guillon, Cécile Rebière, Elie Azoulay, Benoit Misset, Stephane Ruckly, Maïté Garrouste-Orgeas, Nancy Kentish-Barnes, Jacques Duranteau, Marie Thuong, Liliane Joseph, Anne Renault, Olivier Lesieur, Anne-Gaelle Si Larbi, Gérald Viquesnel, Benjamin Zuber, Sophie Marque, Stanislas Kandelman, Nicolas Pichon, Bernard Floccard, Marion Galon, Sylvie Chevret, Nancy Kentish-Barnes, Valérie Seegers, Stéphane Legriel, Samir Jaber, Jean Yves Lefrant, Danielle Reuter, Olivier Guisset, Christophe Cracco, Amélie Seguin, Jacques Durand-Gasselin, Marine Thirion, Zoé Cohen-Solal, Hélène Foulgoc, Julien Rogier, Elsa Delobbe, Frédérique Schortgen, Pierre Asfar, Boisramé-Helms Julie, David Grimaldi, Grelon Fabien, Nadia Anguel, Lasocki Sigismond, Henry-Lagarrigue Matthieu, Frédéric Gonzalez, Legay François, Christophe Guitton, Maleka Schenck, Doise Jean-Marc, Peter Radermacher, Nancy Kentish-Barnes, Joseph Nsiala Makunza, Mejeni Kamdem Nathalie, Akilimali Pierre, Kilembe Manzanza Adolphe, Rafael Mahieu, Thomas Reydel, Angéline Jamet, Nicolas Chudeau, Julien Huntzinger, Steven Grange, Anne Courte, Jérémie Lemarie, Sébastien Gibot, Julia Champey, Jean Dellamonica, Damien Du Cheyron, Damien Contou, Jean-Marc Tadié, Martin Cour, Gaetan Beduneau, Antoine Marchalot, Laurent Guérin, Sebastien Jochmans, Nicolas Terzi, Sebastien Preau, Christian Brun-Buisson, Armand Mekontso Dessap, Meryl Vedrenne-Cloquet, Sophie Breinig, Camille Jung, Maxime Brussieux, Marie-Odile Marcoux, Xavier Durrmeyer, Renaud Blondé, François Angoulvant, Jérôme Grasset, Jérôme Naudin, Stéphane Dauger, Solenn Remy, Karine Kolev-Descamp, Julie Demaret, Guillaume Monneret, Etienne Javouhey, Maryline Chomton, Michaël Sauthier, Emilie Vallieres, Philippe Jouvet, Guillaume Geslain, Isabelle Guellec, Jérôme Rambaud, Matthieu Schmidt, Peter Schellongowski, Amandine Dorget, Nicolo Patroniti, Fabio Silvio Taccone, Dinis Reis Miranda, Jean Reuter, Hélène Prodanovic, Marc Pierrot, Martin Balik, Sunghoon Park, Claude Guérin, Laurent Papazian, Reignier Jean, Louis Ayzac, Anderson Loundou, Jean-Marie Forel, Mehdi Mezidi, Mylène Aublanc, Sophie Perinel-Ragey, Floriane Lissonde, Aurore Louf-Durier, Romain Tapponnier, Hodane Yonis, Remi Coudroy, Jean-Pierre Frat, Florence Boissier, Arnaud W Thille, Flore Richard, Hélène Le Gullou-Guillemette, Jonathan Fahri, Achille Kouatchet, Laetitia Bodet-Contentin, Denis Garot, Déborah Le Pennec, Laurent Vecellio, Elsa Tavernier, Pierre François Dequin, Jonathan Messika, Yolaine Martin, Natacha Maquigneau, Christelle Puechberty, Annabelle Stoclin, Serge Villard, Aline Dechanet, Audrey De Jong, Marion Monnin, Mehdi Girard, Gérald Chanques, Nicolas Molinari, Maxens Decavèle, Sébastien Campion, Roukia Ainsouya, Marie-Cécile Niérat, Mathieu Raux, Thomas Similowski, Alexandre Demoule, Keyvan Razazi, Martial Tchir, Faten May, Guillaume Carteaux, Rougevin-Baville Pauline, Andronikof Marc, Jean Pierre Bedos, Koukabi Mehrsa, Carole Mauger-Briche, François Mijon, Pierre Trouiller, Benjamin Sztrymf, Pierre Cretallaz, Romain Mermillod-Blondin, Dominique Savary, Ines Sedghiani, Hamdi Doghri, Asma Jendoubi, Dhekra Hamdi, Mohamed Ali Cherif, Youssef Zied El Hechmi, Jerbi Zouheir, Nicolas Persico, Francois Maltese, Cécile Ferrigno, Amandine Bablon, Cécile Marmillot, Antoine Roch, Ines Sedghiani, Grégory Papin, Marc Gainnier, Laurent Argaud, Adrie Christophe, Bertrand Souweine, Dany Goldgran-Toledano, Guillaume Marcotte, Anne Sylvie Dumenil, Schwebel Carole, Jerôme Cecchini, Samuel Tuffet, Muriel Fartoukh, Damien Roux, Martial Thyrault, Mekontso Dessap Armand, Simon Chauveau, Nadège Wesner, Laurence Monnier-Cholley, Naïke Bigé, Hafid Ait-Oufella, Bertrand Guidet, Vincent Dubée, Pierre Labroca, Jérémie Lemarié, Gérard Chiesa, Isabelle Laroyenne, Léo Borrini, Rémi Klotz, Quoc Phan Sy, Marie-Christine Cristina, Jean Paysant, Pierre Fillâtre, Arnaud Gacouin, Matthieu Revest, Pierre Tattevin, Erwan Flecher, Yves Le Tulzo, Matthieu Jamme, Fabrice Daviaud, Nathalie Marin, Michael Thy, Baptiste Duceau, Fanny Ardisson, Valade Sandrine, Marion Venot, Benoît Schlemmer, Lara Zafrani, Stéphanie Pons, Lenka Styfalova, Lila Bouadma, Aguila Radjou, Jordane Lebut, Bruno Mourvillier, Richard Dorent, Marie-Pierre Dilly, Patrick Nataf, Michel Wolff, Aëlle Le Gall, Simon Bourcier, Yacine Tandjaoui-Lambiotte, Vincent Das, Mikael Alves, Naïke Bigé, Chtara Kamilia, Ammar Rania, Najeh Baccouch, Olfa Turki, Hmida Chokri Ben, Mabrouk Bahloul, Mounir Bouaziz, Claire Dupuis, Anne Perozziello, Julien Letheulle, Marc Valette, Cécile Herrmann-Storck, Laura Crosby, Khalid Elkoun, Benjamin Madeux, Frédéric Martino, Hélène Migueres, Pascale Piednoir, Matthias Posch, Guillaume Thiery, Minh-Tu Huynh-Ky, Pierre Alexandre Bouchard, Jean-François Sarrazin, François Lellouche, Mai-Anh Nay, Brice Lortat-Jacob, Bertrand Rozec, Marion Colnot, Nicolas Belin, Loïc Barrot, Jean-Christophe Navellou, Cyrille Patry, Claire Chaignat, Melanie Claveau, Frédéric Claude, Cécile Aubron, Zoe Mcquilten, Michael Bailey, Jasmin Board, Heidi Buhr, Bruce Cartwright, Mark Dennis, Paul Forrest, Carol Hodgson, David Mcilroy, Deirdre Murphy, Lynnette Murray, Vincent Pellegrino, David Pilcher, Jayne Sheldrake, Huyen Tran, Shirley Vallance, Jamie Cooper, Camille Bombled, Charles Vidal, Dimitri Margetis, Julien Amour, Domien Coart, Jasperina Dubois, Tom Van Herpe, Dieter Mesotten, Sébastien Bailly, Jc Lucet, Alain Lepape, François L'hériteau, Martine Aupée, Caroline Bervas, Sandrine Boussat, Anne Berger-Carbonne, Anaïs Machut, Anne Savey, Jean-Jacques Tudesq, Sandrine Valade, Lionel Galicier, Cédric De Bazelaire, Nicolas Munoz-Bongrand, Xavier Mignard, Lucie Biard, Djamel Mokart, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Pierre Perez, Anne Pascale Meert, Dominique Benoit, Eric Mariotte, Franck Ehooman, Rebecca Hamidfar-Roy, Yannick Hourmant, Arnaud Mailloux, Alexandra Beurton, Jean-Louis Teboul, Valentina Girroto, Galarza Laura, Christian Richard, Xavier Monnet, Vincent Dubée, Hamid Merdji, Julien Dang, Gabriel Preda, Jean-Luc Baudel, Cyrielle Desnos, Michel Zeitouni, Ines Belaroussi, Antoine Parrot, Clarisse Blayau, Jean-Pierre Fulgencio, Christophe Quesnel, Vincent Labbe, Marc Pineton De Chambrun, François Beloncle, Sybille Merceron, Yannick Fedun, Bernard Lecomte, Jérôme Devaquet, Marc Puidupin, Bruno Verdière, Zahir Amoura, Constance Vuillard, Jais Xavier, Delphine Bourlier, Amar David, Sattler Caroline, Montani David, Simmoneau Gerald, Sitbon Olivier, Marc Humbert, Savale Laurent, Olivier Dujardin, Adrien Bouglé, Hamou Nora Ait, Joe Elie Salem, Najoua El-Helali, Zoé Coppere, Aude Gibelin, Clementine Taconet, Michel Djibre, Adel Maamar, Elen Colobert, Pierre Fillatre, Fabrice Uhel, Christophe Camus, Josquin Moraly, Redouane Dahoumane, Eric Maury, Boun Kim Tan, Vivier Emmanuel, Misslin Pauline, Parmeland Laurence, Poirié Philippe, Jean-Ralph Zahar, Haond Catherine, Pommier Christian, Ait-Bouziad Karim, Hocine Mounia, Témime Laura, Vero Hanitra Rasoldier, Guy Mager, Jean-Pierre Eraldi, Stéphanie Gelinotte, François Bougerol, Julien Dehay, Jean-Philippe Rigaud, Pierre Louis Declercq, Julien Michel, Nejla Aissa, Sandrine Henard, Philippe Guerci, Ichraq Latar, Bruno Levy, Nicolas Girerd, Antoine Kimmoun, Saousen Ben Abdallah, Sabrine Nakaa, Kmar Hraiech, Dhouha Ben Braiek, Ali Adhieb, Abdelwaheb M'ghirbi, Ali Ousji, Zeineb Hammouda, Fekri Abroug, Walid Sellami, Zied Hajjej, Walid Samoud, Iheb Labbene, Mustapha Ferjani, Fatma Kaaniche Medhioub, Rania Allela, Najla Ben Algia, Samar Cherif, Delphine Attia, Andrianjafy Herinjatovo, Xavier Laborne Francois, Med Aziz Bouhouri, Mohamed Taoufik Slaoui, A Soufi, K Khaleq, D Hamoudi, A Nsiri, R Harrar, Eric Maury, Suzanne Goursaud, Maxime Gauberti, Paul-Emile Labeyrie, Thomas Gaberel, Véronique Agin, Eric Maubert, Denis Vivien, Clément Gakuba, Anwar Armel, Rchi Abdou, Samira Kalouch, Khalid Yaqini, Aziz Chlilek, Walid Sellami, Soumaya Ben Yedder, Alexandre Tonnelier, Fabien Hervé, Guillaume Halley, Jean-Luc Frances, Mickael Moriconi, Mathieu Saoli, Aude Garnero, Didier Demory, Jean Michel Arnal, Bertrand Canoville, Cédric Daubin, Jennifer Brunet, Hassen Ben Ghezala, Salah Snouda, Chiekh Imen Ben, Moez Kaddour, Islem Ouanes, Mahdi Marzouk, Françoise Haniez, Hélène Jaillet, Henri Maas, Pierre Andrivet, Christian Darné, François Viau, Hassen Ben Ghezala, Islem Ouanes, Laurence Dangers, Claire Montlahuc, Sébastien Perbet, Islem Ouanes, Zeineb Hamouda, Sabrine Nakee, Lamia Ouanes-Besbes, Khaoula Meddeb, Ahmed Khedher, Nesrine Sma, Jihene Ayachi, Messaouda Khelfa, Nesrine Fraj, Hend Ben Lakhal, Hedia Hammed, Raja Boukadida, Hajer Hafsa, Imed Chouchene, Mohamed Boussarsar, Braiek Dhouha Ben, Lamia Ouanes-Besbes, Kaoutar Benatti, A Dafir, W Aissaoui, W Elallame, W Haddad, R Cherkab, C Elkettani, L Barrou, Zakaria Ait Hamou, Xavier Repessé, Cyril Charron, Alix Aubry, Alexis Paternot, Julien Maizel, Michel Slama, Antoine Vieillard-Baron, Ahlem Trifi, Sami Abdellatif, Meriem Fatnassi, Foued Daly, Rochdi Nasri, Khaoula Ben Ismail, Salah Ben Lakhal, Florian Bazalgette, Aurelien Daurat, Claire Roger, Laurent Muller, Denis Doyen, Rémi Plattier, Alexandre Robert, Hervé Hyvernat, Gilles Bernardin, Mathieu Jozwiak, Julia Gimenez, Pablo Mercado, François Depret, Najla Tilouch, Houda Mater, Ben Sik Ali Habiba, Oussama Jaoued, Rim Gharbi, Mohamed Fekih Hassen, Souheil Elatrous, Pierre Pasquier, Quentin Vuillemin, Jean-Vivien Schaal, Thibault Martinez, Sandrine Duron, Marion Trousselard, Pierre-Eric Schwartzbrod, Thomas Baugnon, Laurent Dupic, Caroline Duracher Gout, Laure De Saint Blanquat, Sylvie Séguret, Gaelle Le Ficher, Gilles Orliaguet, Philippe Hubert, Naïke Bigé, Guillaume Leblanc, Raphael Briand, Lucas Brousse, Valentine Brunet, Léonard Chatelain, Dominique Prat, Frédéric Jacobs, Nadège Demars, Olfa Hamzaoui, Guy Moneger, Benjamin Sztrymf, Emilie Duburcq-Gury, Léa Satre-Buisson, Thibault Duburcq, Julien Poissy, Laurent Robriquet, Merce Jourdain, Thierry Sécheresse, Mattéo Miquet, Alexis Simond, Pascal Usseglio, Yamina Hamdaoui, Mohamed Boussarsar, Victoire Desailly, Patrick Brun, Pauline Iglesias, Jérémie Huet, Clémence Masseran, Antoine Claudon, Clément Ebeyer, Thomas Truong, Antoine Tesnière, Alexandre Mignon, Stéphane Gaudry, Dabor Resiere, Ruddy Valentino, Julien Fabre, Benoit Roze, Jean-Louis Ferge, Cyrille Charbatier, Sabia Marie, Michel Scholsser, Signate Aitsatou, Mathieu Raad, Andre Cabie, Hossein Mehdaoui, Clement Cousin, Christophe Rousseau, Jean-François Llitjos, Fanny Alby-Laurent, Julie Toubiana, Nadia Belaidouni, Marlène Cherruault, Jérome Tamburini, Didier Bouscary, Sarah Fert, Eugénie Delile, Emmanuel Besnier, David Coquerel, Rémi Nevière, Vincent Richard, Fabienne Tamion, Chaojie Wei, Huguette Louis, Schmitt Margaux, Albuisson Eliane, Orlowski Sophie, Antoine Kimmoun, Zakaria Riad, Marine Coroir, Bernard Rémy, Bombled Camille, Jeremie Joffre, Philippe Aegerter, Dejan Ilic, Marc Ginet, Caroline Pignard, Philippe Nguyen, Guillaume Mourey, Emmanuel Samain, Sebastien Pili-Floury, Romain Jouffroy, Caill Nicolas, Jean-Claude Alvarez, Maraffi Tomasso, Pascal Philippe, Jean-Herlé Raphalen, J Baud Frédéric, Benoit Vivien, Carli Pierre, Frederic Baud, Hana Fredj, Youssef Blel, Nozha Brahmi, Hassen Ben Ghezala, Anne-Sophie Hanak, Isabelle Malissin, Joel Poupon, Patricia Risede, Lucie Chevillard, Bruno Megarbane, Manel Barghouth, Aymen M'rad, Marwa Ben Hmida, Hafedh Thabet, Hao Liang, Jacques Callebert, Camille Lagard, Bruno Megarbane, Sahar Habacha, Bassem Chatbri, Christophe Camillerapp, Laurence Labat, Marion Soichot, Pierre Garçon, Antoine Goury, Lamia Kerdjana, Sebastian Voicu, Nicolas Deye, Bruno Megarbane, Anwar Armel, Benqqa Anas, Mezgui Othman, S Moumine, S Kalouch, K K Yakini, A Chlilek, Ahmed Hajji, Assaad Louati, Ammar Khaldi, Aida Borgi, Nargess Ghali, Asma Bouziri, Khaled Menif, Jaballah Najla Ben, Anwar Armel, Jeanne Brochon, Mihaela Dumitrescu, Sarah Thévenot, Jean-Pascal Saulnier, Khaled Husseini, Catherine Laland, Julie Cremniter, Anne Bousseau, Olivier Castel, Cassandra Brémaud-Csizmadia, Margot Diss, Aurélie Portefaix, Julien Berthiller, Yves Gillet, Nabil Tabet Aoul, Ali Douah, Zakaria Addou, Houari Youbi, Mohamed Moussati, Kamel Belhabiche, Souad Mir, Sanaa Abada, Zerhouni Amel, Nabil Aouffen, Zina Bouzit, Ahmed H Grati, Gilles F Dhonneur, Mohamed Boussarsar, Nicolas Lau, Ilham Mezhari, Nicolas Roucaud, Matthieu Le Meur, Rémi Paulet, Jean-Michel Coudray, Wahiba Imène Ghomari, Reda Boumlik, Vincent Peigne, Jean-Louis Daban, Mathieu Boutonnet, Bernard Lenoir, Hafiani Yassine, Cheikh Chaigar Mohamed, Allali Khalid, Moussaid Ihssan, Elyoussoufi Said, Salmi Said, Amira Ben Jazia, Jaziri Fatima, Skouri Wafa, Bennasr Maha, Ben Abdelghni Khaoula, Turki Sami, B Abdallah Taeib, Fatma Kaaniche Medhioub, Virginie Rollet-Cohen, Philippe Sachs, Zied Merchaoui, Sylvain Renolleau, Mehdi Oualha, Maxime Eloi, Sandrine Jean, Maryne Demoulin, Cécile Valentin, Julia Guilbert, Hervé Walti, Ricardo Carbajal, Pierre-Louis Leger, Yasemin Karaca-Altintas, Astrid Botte, Julien Labreuche, Elodie Drumez, Patrick Devos, Franck Bour, Francis Leclerc, Ayari Ahmed, Menif Khaled, Assaad Louati, Borgi Aida, Khaldi Ammar, Ghali Narjess, Hajji Ahmed, Bouziri Asma, Nejla Ben Jaballah, Pierre-Louis Leger, Julien Pansiot, Valérie Besson, Bruno Palmier, Olivier Baud, Bruno Cauli, Christiane Charriaut-Marlangue, Amélie Mansuy, Fabrice Michel, Stéphane Le Bel, Julia Boubnova, Fabrice Ughetto, Caroline Ovaert, Virginie Fouilloux, Olivier Paut, Matthias Jacquet-Lagrèze, Nicolas Tiebergien, Najib Hanna, Jean-Noël Evain, Florent Baudin, Sonia Courtil-Teyssedre, Dominique Bompard, Marc Lilot, Laurent Chardonal, Jean-Luc Fellahi, Claire Claverie, Guillaume Pouessel, Aimée Dorkenoo, Jean-Marie Renaudin, Mireille Eb, Antoine Deschildre, Stéphane Leteurtre, Hafiani Yassine, Belkadi Kamal, Oboukhlik Adil, Aalalam Ouafa, Moussaoui Mouhamed, Charkab Rachid, Barrou Lahoucine, Fahmi Dachraoui, Sabrine Nakkaa, Hammouda Zaineb, Dorra Mlika, Olfa Gloulou, Mohamed Boussarsar, Setti-Aouicha Zelmat, Djamila-Djahida Batouche, Belkacem Chaffi, Fatima Mazour, Nadia Benatta, Ines Fathallah, Rafaa Aloui, Aymen Zoubli, Nadia Kouraichi, Ines Fathallah, N Kouraichi, Shireen Salem, Eric Vicaut, Bruno Megarbane, David Ambroise, Anne-Marie Loriot, Emmanuel Bourgogne, Bruno Megarbane, Hatem Ghadhoune, Guissouma Jihene, Insaf Trabelsi, Hend Allouche, Habib Brahmi, Mohamed Samet, Hatem El Ghord, Rodolphe Lebeau, Jean-Louis Laplanche, Nadia Benturquia, Bruno Megarbane, Youssef Blel, A M'rad, Fatma Essafi, A Benabderrahim, Romain Jouffroy, Dabor Resiere, Bruno Sanchez, Jocelyn Inamo, Bruno Megarbane, Djamila-Djahida Batouche, Amel Zerhouni, Kheira Tabeliouna, Amine Negadi, Zahia Mentouri, Fanny Le Gall, Jean-Luc Hanouz, Hervé Normand, Abdo Khoury, Fatimata Seydou Sall, Alban De Luca, Aurore Pugin, Lionel Pazart, Chrystelle Vidal, Franck Leroux, Abdo Khoury, Erwan L'Her, Nicolas Marjanovic, Abdo Khoury, Thibault Desmettre, Christophe Lambert, Sophie Perinel Ragey, Loredana Baboi, Jean-Etienne Bazin, Catherine Koffel, Gilles Dhonneur, Zina Bouzit, Larbi Bradai, Issam Ben Ayed, Fethi Aissa, Hakim Haouache, Yoann Marechal, Patrick Biston, Michael Piagnerelli, Perrine Bortolotti, Delphine Colling, Vincent Colas, Benoit Voisin, Florent Dewavrin, Thierry Onimus, Patrick Girardie, Fabienne Saulnier, Tomas Urbina, Yann Nguyen, Anne-Lise Druoton, Marc Soudant, Damien Barraud, Marie Conrad, Aurélie Cravoisy-Popovic, Lionel Nace, Pierre-Edouard Bollaert, Ruste Martin, Laurent Bitker, Jean-Christophe Richard, David Brossier, Isabelle Goyer, Christopher Marquis, Marie Lampin, Alain Duhamel, Hélène Béhal, Tahar Dhaoui, Véronique Godeffroy, Eve Devouge, Dominique Evrard, Florence Delepoulle, Sylvie Racoussot, Bruno Grandbastien, Marie Lampin, Claire Heilbronner, Emeline Roy, Alexandra Masson, Alice Hadchouel-Duvergé, Virginie Rigourd, Elise Delacroix, Isabelle Wroblewski, Isabelle Pin, Anne Ego, Valerie Payen, Thierry Debillon, Anne Millet, Julien Denot, Véronique Berthelot, Emilie Thueux, Marie Reymond, Alexandra De Larrard, Alain Amblard, Pierre-Louis Leger, Nabil Tabet Aoul, Virginie Lemiale, Johanna Oziel, Noelle Brule, Anne-Sophie Moreau, Takoua Marhbène, Salma Sellami, Amira Jamoussi, Samia Ayed, Emna Mhiri, Leila Slim, Jalila Ben Khelil, Mohamed Besbes, Sylvain Chawki, Aicha Hamdi, Magali Ciroldi, Alice Cottereau, Edouard Obadia, Yoann Zerbib, Claire Andrejak, Sylvie Ricome, Hervé Dupont, François Baudin, Pauline Dureau, Audrey Tanguy, Charlotte Arbelot, Hassen Kais Ben, Ahmed Charfeddine, Benjamin Granger, Lucile Laporte, Coralie Hermetet, Kais Regaieg, Rim Khemakhem, Hedi Chelly, Chaigar Mohammed Cheikh, Hamid Mountij, Kawtar Rghioui, Wafae Haddad, Rachid Cherkab, Houcine Barrou, Aitmouden Naima, Othmani M Bennani, Kais Regaieg, Ahmed Douib, Amal Samet, Pierre-Julien Cungi, Cédric Nguyen, Jean Cotte, Erwan D'aranda, Eric Meaudre, Jean-Phillipe Avaro, Mohamed Taoufik Slaoui, Amel Mokline, Imene Rahmani, Achraf Laajili, Helmi Amri, Lazheri Gharsallah, Bahija Gasri, Sofiene Tlaili, Rym Hammouda, Amen Allah Messadi
No abstract text is available yet for this article.
January 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/27998289/effects-of-low-doses-of-esmolol-on-cardiac-and-vascular-function-in-experimental-septic-shock
#12
Chaojie Wei, Huguette Louis, Margaux Schmitt, Eliane Albuisson, Sophie Orlowski, Bruno Levy, Antoine Kimmoun
BACKGROUND: Administration of a selective β1-blocker, such as esmolol, in human septic shock has demonstrated cardiovascular protective effects related to heart rate reduction. Certain experimental data also indicate that esmolol exerts systemic anti-inflammatory and beneficial effects on vascular tone. Thus, the present study aimed to determine whether a non-chronotropic dose of esmolol maintains its protective cardiovascular and anti-inflammatory effects in experimental septic shock...
December 21, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27858487/probing-for-the-presence-of-glucosinolates-in-three-drypetes-spp-drypetes-euryodes-hiern-hutch-drypetes-gossweileri-s-moore-drypetes-laciniata-hutch-and-two-rinorea-spp-rinorea-subintegrifolia-o-ktze-and-rinorea-woermanniana-b%C3%A3-ttner-engl-from-gabon
#13
Sabine Montaut, Gina R De Nicola, Huguette Agnaniet, Yves Issembe, Patrick Rollin, Chantal Menut
Drypetes euryodes (Hiern) Hutch., Drypetes gossweileri S. Moore, Drypetes laciniata Hutch. (Putranjivaceae), Rinorea subintegrifolia O. Ktze, and Rinorea woermanniana (Büttner) Engl. (Violaceae) from Gabon were probed for the presence of glucosinolates (GLs). When present, the GLs were identified and quantified by HPLC analysis. 2-Hydroxy-2-methyl GL (1) was the major GL in the cork of D. euryodes. Moreover, 4-hydroxybenzyl GL (2) was the major GL in the seed of D. gossweileri whereas the bark contained 2 as the minor GL and benzyl GL (3) was the major one...
February 2017: Natural Product Research
https://www.readbyqxmd.com/read/27642475/-current-status-of-schistosomiasis-in-santchou-health-area-santchou-health-district-cameroon-western-region
#14
Huguette Nguedie Tchouanguem, Florent Ymele Fouelifack, Basile Keugoung, Loic Dongmo Fouelifa, Roger Somo Moyou
INTRODUCTION: Schistosomiasis, the second endemic parasitic infection in the world, is a parasitosis caused by trematodes from the genus Schistosoma. Our study aims to assess the prevalence of different species of schistosomes (Schistosoma mansoni, haematobium and intercalatum) among schoolchildren and to identify risk factors, clinical signs of schistosomiasis, and schistosomiasis intermediate host snails in stagnant water. METHODS: We conducted a cross sectional study over a three months period...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27619739/duramycin-porphyrin-conjugates-for-targeting-of-tumour-cells-using-photodynamic-therapy
#15
Laura J Broughton, Francesca Giuntini, Huguette Savoie, Francesca Bryden, Ross W Boyle, Anthony Maraveyas, Leigh A Madden
Duramycin, through binding with phosphatidylethanolamine (PE), has been shown to be a selective molecular probe for the targeting and imaging of cancer cells. Photodynamic therapy aims to bring about specific cytotoxic damage to tumours through delivery of a photosensitising agent and light irradiation. Conjugation to biological molecules that specifically target cancer has been shown to increase photosensitiser (PS) selectivity and decrease damage to surrounding normal tissue. The aim of this study was to target tumour cells with a PE-specific PS therefore duramycin was conjugated to a porphyrin based PS which was achieved via direct reaction with the ε-amino group on the lysine residue near duramycin's N-terminal...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27492245/the-potential-role-of-biomarkers-in-predicting-gestational-diabetes
#16
REVIEW
Huguette S Brink, Aart Jan van der Lely, Joke van der Linden
Gestational diabetes (GD) is a frequent complication during pregnancy and is associated with maternal and neonatal complications. It is suggested that a disturbing environment for the foetus, such as impaired glucose metabolism during intrauterine life, may result in enduring epigenetic changes leading to increased disease risk in adult life. Hence, early prediction of GD is vital. Current risk prediction models are based on maternal and clinical parameters, lacking a strong predictive value. Adipokines are mainly produced by adipocytes and suggested to be a link between obesity and its cardiovascular complications...
September 2016: Endocrine Connections
https://www.readbyqxmd.com/read/27488087/moderate-hypothermia-improves-cardiac-and-vascular-function-in-a-pig-model-of-ischemic-cardiogenic-shock-treated-with-veno-arterial-ecmo
#17
Fabrice Vanhuyse, Nicolas Ducrocq, Huguette Louis, Narimane Al Kattani, Nicolas Laurent, Frédérique Joineau-Groubatch, Aude Falanga, Juan-Pablo Maureira, Antoine Kimmoun, Nicolas Girerd, Nguyen Tran, Bruno Levy
Cardiogenic shock (CS) patients treated with extracorporeal membrane oxygenation (ECMO) have severe cardiac failure, associated with ischemia-reperfusion. The use of moderate hypothermia during ischemia-reperfusion syndrome is supported by experimental data. We therefore studied the effects of moderate hypothermia on cardiac and vascular function in pig ischemic CS treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO). CS was induced in 12 anesthetized pigs by coronary ligation. After 1 h of CS, VA-ECMO was initiated and pigs were randomized to normothermia (38°C) or moderate hypothermia (34°C) during 8 h...
February 2017: Shock
https://www.readbyqxmd.com/read/27459848/genotypic-characterization-of-drug-resistant-mycobacterium-tuberculosis-in-quebec-2002-2012
#18
Joanna Spinato, Élyse Boivin, Émilie Bélanger-Trudelle, Huguette Fauchon, Cécile Tremblay, Hafid Soualhine
BACKGROUND: The increasing emergence of drug-resistant tuberculosis presents a threat to the effective control of tuberculosis (TB). Rapid detection of drug-resistance is more important than ever to address this scourge. The purpose of this study was to genotypically characterize the first-line antitubercular drug-resistant isolates collected over 11 years in Quebec. RESULTS: The main mutations found in our resistant strains collection (n = 225) include: the S315T substitution in katG (50...
July 26, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27389361/analysis-of-genetic-diversity-in-the-chloroquine-resistant-gene-pfcrt-in-field-plasmodium-falciparum-isolates-from-five-regions-of-the-southern-cameroon
#19
Huguette Gaelle Ngassa Mbenda, Aparup Das
Understanding the population genetics of genes which shape resistance to antimalarial drugs can help in devising novel control strategies. The high spread of the resistant strains of the malaria parasite Plasmodium falciparum pose a greater challenge than before to the control programs across the world. Specific mutations in the P. falciparum chloroquine resistant transporter gene "Pfcrt" have been associated with resistance to not only chloroquine, but also to amodiaquine, one of the artemisinin partners used in Cameroon for the treatment of uncomplicated malaria...
October 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27382488/using-soluble-transferrin-receptor-and-taking-inflammation-into-account-when-defining-serum-ferritin-cutoffs-improved-the-diagnosis-of-iron-deficiency-in-a-group-of-canadian-preschool-inuit-children-from-nunavik
#20
Huguette Turgeon O'Brien, Rosanne Blanchet, Doris Gagné, Julie Lauzière, Carole Vézina
The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs. Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive protein (CRP) level and (2) SF < 15 or <50 μg/L with CRP ≤ 5 or >5 mg/L, respectively. IDE corresponded to iron depletion combined with total iron binding capacity > 72 μmol/L and/or transferrin saturation < 16%...
2016: Anemia
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