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Nadine Homagk, Tina Jarmuzek, Gunther O Hofmann, Lars Homagk
Spondylodiscitis is a rare but serious infection of the spine. Recognised methods of treatment include immobilisation and systemic antibiotics. However, available data for specific and recommendations for continuing treatment are also rare. The aim of the present study is the optimisation of the therapy of spondylodiscitis using a clinical pathway that depends on a classification of spondylodiscitis. From 1 October 1998 to 31 December 2013, a classification of the severity of spondylodiscitis was established, including specific treatment recommendations...
October 19, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
Tim Bobrowski, Elena González Arribas, Roland Ludwig, Miguel D Toscano, Sergey Shleev, Wolfgang Schuhmann
We present a transparent and flexible self-charging biosupercapacitor based on an optimised mediator- and membrane-free enzymatic glucose/oxygen biofuel cell. Indium tin oxide (ITO) nanoparticles were spray-coated on transparent conducting ITO supports resulting in a flocculent, porous and nanostructured electrode surface. By this, high capacitive currents caused by an increased electrochemical double layer as well as enhanced catalytic currents due to a higher number of immobilised enzyme molecules were obtained...
October 11, 2017: Biosensors & Bioelectronics
Elisabeth Maria Haas, Elias Volkmer, Riccardo E Giunta
Background/Aim Preliminary data suggest that an intraarticular autologous fat transplant may be useful in osteoarthritis (OA) of the CMC-1 joint. This prospective, non-randomised pilot study investigates this new method with a view to clinical outcomes compared with intraarticular corticosteroid injection. Patients and Methods 17 women and 7 men with an average age of 63.3 (47-75) years with symptomatic OA were included in the study. In 12 patients, a radiologically guided injection of 1-1.5 ml of adipose tissue was carried out after transumbilical liposuction of 10 ml of abdominal fat...
October 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Majid Kazemian Abyaneh, Tohru Araki, Burkhard Kaulich
Gold nanorods (GNRs) have been fabricated by a novel polymer-immobilised seed mediated method using ultraviolet (UV) photoreduced gold-polymethylmethacrylate (Au-PMMA) nanocomposites as a seed platform and characterised at sub-micron scale regime with synchrotron-based techniques; near-edge X-ray absorption fine structure (NEXAFS) spectroscopy and X-ray fluorescence (XRF) mapping. In this report, it is shown that investigating polymer nanocomposites using combination of XRF mapping and NEXAFS spectromicroscopy can help to see the growth phenomenon from different perspective than conventional characterisation techniques...
October 16, 2017: Nanomaterials
Haiying Yang, Xiuting Li, Christopher Batchelor-McAuley, Stanislav V Sokolov, Enno Kätelhön, Richard G Compton
Nafion particles novelly doped with ruthenium (II) tris(2,2'-bipyridyl) are synthesized by using the re-precipitation method. Characterization including SEM sizing and quantification of Ru(bpy)32+ in the Nafion particles via UV-Vis spectroscopy was conducted. The synthesized Ru-Nafion particles were investigated electrochemically at both ensemble and single particle levels. Voltammetry of the drop-cast Ru-Nafion particles evidences the successful incorporation of Ru(bpy)32+ into the Nafion particle but only a small fraction of the incorporated Ru(bpy)32+ was detected due at least in part to the formation of the likely agglomerated and irregular 'mat' associated with the dropcast technique...
October 16, 2017: Chemistry: a European Journal
Axel Fudickar, Matthias Gruenewald, Beate Fudickar, Moritz Hill, Martin Wallenfang, Julia Hüllemann, Dana Voss, Amke Caliebe, Johann B Roider, Markus Steinfath, Felix Treumer
BACKGROUND: For intraocular surgery, most authors recommend general anaesthesia including intubation and neuromuscular blockade to avoid complications by patient movements. However, anaesthesia using a laryngeal mask and avoidance of muscle relaxants is common clinical practice. Purpose of this prospective observational study was to compare the incidence of eye movement and deviation of the eye axis during general anaesthesia adjusted to minimal alveolar concentration (MAC) for pars plana-vitrectomy (PPV) using a laryngeal mask without neuromuscular blockade (LM) versus endotracheal intubation and neuromuscular blockade (INT)...
October 12, 2017: Minerva Anestesiologica
Samer Aphrham, Qing Pan, Sarah F Zaccarine, Kevin M Felter, Jos Thieme, Karin J H van den Nieuwenhuijzen, Johan E Ten Elshof, Annemarie Huijser
The effect of water addition during preparation of a CH3NH3PbI3 layer on the photodynamics is studied by femtosecond transient absorption. Both the regular perovskite and the aqueous analogue show charge thermalisation on a ca. 500 fs time scale. This process is however less pronounced in the latter layer. The spectral feature associated with hot charges does not fully decay on this time scale, but also shows a long-lived (sub-ns) component. As water molecules may interfere with the hydrogen bonding between the CH3NH3+ cations and the inorganic cage, this effect is possibly caused by immobilisation of cation motion, suggesting a key role of CH3NH3+ dipole reorientation in charge thermalisation...
October 12, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Susana Velasco-Lozano, Eunice S da Silva, Jordi Llop, Fernando López-Gallego
The enzymatic synthesis of -amino acids appears as a sustainable and efficient alternative to chemical processes, where achieving enantiopure products is a hard task. To more efficiently adress this synthesis, we desinged and fabricate a hierarchical architecture that irreversibly co-immobilises an amino acid dehydrogenase with polyethyleneimine on porous agarose beads. The cationic polymer acts as an irreversible anchoring layer for the formate dehydrogenase. In this architecture, the two enzymes and the polymer co-localise across the whole microstructure of the porous carrier...
October 9, 2017: Chembiochem: a European Journal of Chemical Biology
Nur Hasiba Kamaruddin, Ahmad Ashrif A Bakar, Nadhratun Naiim Mobarak, Mohd Saiful Dzulkefly Zan, Norhana Arsad
The study of binding affinity is essential in surface plasmon resonance (SPR) sensing because it allows researchers to quantify the affinity between the analyte and immobilised ligands of an SPR sensor. In this study, we demonstrate the derivation of the binding affinity constant, K, for Pb(2+) and Hg(2+) ions according to their SPR response using a gold/silver/gold/chitosan-graphene oxide (Au/Ag/Au/CS-GO) sensor for the concentration range of 0.1-5 ppm. The higher affinity of Pb(2+) to binding with the CS-GO sensor explains the outstanding sensitivity of 2...
October 6, 2017: Sensors
Jacques Henry O'Dell, Michael David Kock, Peter Neil Thompson, Leith Carl Rodney Meyer
Naltrexone is used to antagonise etorphine immobilisation, but a safe and effective dose for this purpose has not been objectively determined. Eight domestic goats were immobilised with etorphine (0.07 mg/kg) eight times at ≥13 day intervals. Naltrexone at doses of 0.5, 1, 2, 5, 10, 20 and 40 mg/mg etorphine were administered intravenously 17 minutes after etorphine injection. Effectiveness of antagonism was recorded based on recovery and renarcotisation scores and clinical observations. All doses produced rapid recovery to the point of standing (median 59 seconds, range 33-157 seconds), with no significant differences in recovery times (P=0...
October 4, 2017: Veterinary Record
M Nambiar, D Owen, P Moore, A Carr, M Thomas
INTRODUCTION: Traumatic inferior shoulder dislocation (ISD) is rare, estimated to occur in 0.5% of all shoulder dislocations. We describe the demographics, natural history and outcome of this injury. HYPOTHESIS/AIM: The aim of the study is to provide a summary of the demographics, clinical presentation, management and outcome of patients who suffer ISD METHODS: We conducted a systematic review of the English language literature on ISD using PubMed, Medline, CINHAL, Cochrane Database and Evidence-Based Medicine Reviews...
October 3, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Jane J Leung, Julien Warnan, Dong Heon Nam, Jenny Z Zhang, Janina Willkomm, Erwin Reisner
The development of photoelectrodes capable of light-driven hydrogen evolution from water is an important approach for the storage of solar energy in the form of a chemical energy carrier. However, molecular catalyst-based photocathodes remain scarcely reported and typically suffer from low efficiencies and/or stabilities due to inadequate strategies for interfacing the molecular component with the light-harvesting material. In this study, we report the straightforward preparation of a p-silicon|mesoporous titania|molecular catalyst photocathode assembly that is active towards proton reduction in aqueous media with an onset potential of +0...
July 1, 2017: Chemical Science
H M Jang, S-E Jang, M J Han, D-H Kim
To better understand the role of gut microbiota in the anxiety, we isolated bifidobacteria and lactobacilli from the human faecal microbiota, investigated their inhibitory effects on the expression of interleukin (IL)-6 and tumour necrosis factor (TNF)-α in lipopolysaccharide-stimulated macrophages, and examined the anxiolytic-like effect of Bifidobacterium adolescentis IM38 in mice treated with or without immobilisation stress using the elevated plus maze (EPM) task. Oral administration of IM38 at a dose of 1×10(9) cfu/mouse showed a significant anxiolytic-like effect both in mice exposed to immobilisation stress and in control mice using the EPM test (P<0...
October 3, 2017: Beneficial Microbes
R Sinha, P Srivastava
Numerous antibiotics as secondary metabolites have been isolated from microbes specifically Streptomyces sp. Rapamycin is one of these, which exhibits many roles as immunosuppressant, antifungal antibiotic, anti-tumour etc. Constant thrust has been put by many researchers to improve the production of rapamycin by Streptomyces hygroscopicus. Past research show that whole cell immobilisation is a useful strategy for antibiotic production with economical advantage. This study is another attempt in this direction which involves immobilisation of producer organism on various supports such as polyutherane foam, sintered beads, glass beads and foam peanuts...
July 31, 2017: Cellular and Molecular Biology
Sara Muñoz-Pina, José V Ros-Lis, Ángel Argüelles, Carmen Coll, Ramón Martínez-Máñez, Ana Andrés
Darkening processed fruits and vegetables is caused mainly by enzymatic browning through polyphenol oxidase (PPO) action. Accordingly, we explored the potential of four silica-based materials (MCM-41 nanometric size, MCM-41 micrometric size, UVM-7 and aerosil), non-functionalised and functionalised with thiol groups, to inhibit PPO activity in the model system and apple juice. All materials showed relevant performance when immobilising and inhibiting PPO in model systems, and support topology is a main factor for enzyme immobilisation and inhibition...
February 15, 2018: Food Chemistry
Pjotrs A Žguns, Andrei V Ruban, Natalia V Skorodumova
Ordering of dopants and oxygen vacancies is studied for Gd-doped ceria (xGd ≤ 0.25) by means of a combined density functional theory (DFT) and cluster expansion approach, where the cluster interactions derived from DFT calculations are further used in Monte Carlo simulations. The methodology is meticulously tested and the stability of the obtained solutions with respect to the volume change, applied exchange-correlation approximation and other modelling parameters is carefully analysed. We study Gd and vacancy ordering in the case of thermodynamic equilibrium and vacancy ordering for quenched Gd configurations...
October 11, 2017: Physical Chemistry Chemical Physics: PCCP
Yu Liu, Anthony P F Turner, Maojun Zhao, Wing Cheung Mak
A new approach for the facile fabrication of electrochemical biosensors using a biohybrid conducting polymer was demonstrated using glucose oxidase (GOx) and poly (3, 4-ethylenedioxythiophene) (PEDOT) as a model. The biohybrid conducting polymer was prepared based on a template-assisted chemical polymerisation leading to the formation of PEDOT microspheres (PEDOT-MSs), followed by in-situ deposition of platinum nanoparticles (PtNPs) and electrostatic immobilisation of glucose oxidase (GOx) to form water processable GOx-PtNPs-PEDOT-MSs...
September 18, 2017: Biosensors & Bioelectronics
Mudassir Iqbal, Mukesh Dubey, Kerstin McEwan, Uwe Menzel, Mikael Andersson Franko, Maria Viketoft, Dan Funck Jensen, Magnus Karlsson
Biological control is a promising approach to reduce plant diseases caused by nematodes. We tested the effect of the fungus Clonostachys rosea strain IK726 inoculation on nematode community composition in a naturally nematode infested soil in a pot experiment, and the effect of C. rosea on plant health. The numbers of plant-parasitic nematode genera extracted from soil and plant roots decreased by 40 to 73 % when C. rosea was applied, while genera of non-parasitic nematodes were not affected. Soil inoculation of C...
September 12, 2017: Phytopathology
Andrea M Bruder, Nora Shields, Karen J Dodd, Nicholas F Taylor
QUESTION: What is the effect of exercise on increasing participation and activity levels and reducing impairment in the rehabilitation of people with upper limb fractures? DESIGN: Systematic review of controlled trials. PARTICIPANTS: Adults following an upper limb fracture. INTERVENTION: Any exercise therapy program, including trials where exercise was delivered to both groups provided that the groups received different amounts of exercise...
October 2017: Journal of Physiotherapy
Nur Hamidah Abdul Halim, Yook Heng Lee, Radha Swathe Priya Malon Marugan, Uda Hashim
An impedimetric-based biosensor constructed using gold nanoparticles (AuNP) entrapped within titanium dioxide (TiO₂) particles for hydrogen peroxide (H₂O₂) detection is the main feature of this research. The matrix of the biosensor employed the surface of TiO₂, which was previously modified with an amine terminal group using 3-Aminopropyltriethoxysilane (APTS) at a low temperature to create a ready to immobilise surface for the biosensor application. Hemoglobin (Hb), which exhibits peroxidase-like activity, was used as the bioreceptor in the biosensor to detect H₂O₂ in solution...
September 18, 2017: Biosensors
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