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Daniel S Hill, Hans Marynissen
STUDY DESIGN: A retrospective cross-sectional analysis. OBJECTIVE: To describe the provision of a spinal service using an electronic platform to direct management from an external spinal unit, and quantify time taken to obtain definitive management plans whilst under prescribed spinal immobilization. SUMMARY OF BACKGROUND DATA: Most attending district general hospitals following spinal trauma will have stable injuries and normal neurology, with only a small proportion requiring urgent transfer to a specialist centre...
April 12, 2018: Spine
Wejdan Al-Shakarchi, Ali Alsuraifi, Mohammed Abed, Marwan Abdullah, Alan Richardson, Anthony Curtis, Clare Hoskins
Hepatocellular carcinoma is an aggressive form of liver cancer that displays minimal symptoms until its late stages. Unfortunately, patient prognosis still remains poor with only 10% of patients surviving more than five years after diagnosis. Current chemotherapies alone are not offering efficient treatment, hence alternative therapeutic approaches are urgently required. In this work, we highlight the potential of combination of treatment of hepatocellular carcinoma with existing chemotherapies in combination with pro-apoptotic factor cytochrome C...
April 12, 2018: Pharmaceutics
A Khoriati, C Jones, A Abdulkareem, N Ellahee
Fractures of the capitate bone are the second most common injury to a child's wrist but are rarely encountered in isolation. This is reflected in the paucity of described cases in the literature. Their true incidence is unknown as they often do not appear on plain radiographs and may heal without immobilisation. The easiest way to detect these fractures is with an MRI scan. The authors present a rare case of isolated capitate fracture that was initially missed on plain films. This case is important as it highlights the need for a high index of suspicion in paediatric patients with unresolving wrist pain...
December 2017: Trauma Case Reports
Charles E Creissen, Julien Warnan, Erwin Reisner
Dye-sensitised photoelectrochemical (DSPEC) cells have emerged in recent years as a route to solar fuel production. However, fuel-forming photocathodes are presently limited by photo-corrodible narrow band gap semiconductors or the small range of available wide bandgap p-type semiconductors such as NiO that display low performance with dyes. Here, we introduce CuCrO2 as a suitable p-type semiconductor for visible light-driven H2 generation upon co-immobilisation of a phosphonated diketopyrrolopyrrole dye with a Ni-bis(diphosphine) catalyst...
February 14, 2018: Chemical Science
Seyedeh Zeinab Mousavisani, Jahan Bakhsh Raoof, Reza Ojani, Zahra Bagheryan
The detection and inhibition of DNA damage are of great importance in the prevention and treatment of diseases. Developing a simple and sensitive tool for this purpose would be a chance to monitor the DNA damage and could be helpful in introducing some drugs which can prevent this phenomenon. Here, we report a novel and sensitive electrochemical biosensor based on DNA/Au nanoparticles (AuNPs) modified screen printed gold electrode (DNA/AuNPs/SPGE) to investigate the DNA damage process and also to study the protective behavior of deferoxamine (DFO)...
March 28, 2018: Bioelectrochemistry
José M Soriano-Disla, Ulrich Spille, María Gabarrón, Ángel Faz, José A Acosta
The main objective was to evaluate and optimise strategies for the immobilisation or mobilisation of Cd, Cu, Cr, Ni, Pb, and Zn from pyrite ash. Alkaline amendments were used for the immobilisation test: cement, sandstone, marl, marble waste and calcareous crust. The amendments were mixed with pyrite ash at a 1:2 rate, incubated for 28 days, and leachates analysed at the beginning of the experiment (day 0) and after 2, 7, 14 and 28 days. The mobilisation experiment tested metal release from pyrite ash by four concentrations of H2 SO4 (0...
April 4, 2018: Journal of Environmental Management
Katharina Hiebler, Georg J Lichtenegger, Manuel C Maier, Eun Sung Park, Renie Gonzales-Groom, Bernard P Binks, Heidrun Gruber-Woelfler
Within the "compartmentalised smart factory" approach of the ONE-FLOW project the implementation of different catalysts in "compartments" provided by Pickering emulsions and their application in continuous flow is targeted. We present here the development of heterogeneous Pd catalysts that are ready to be used in combination with biocatalysts for catalytic cascade synthesis of active pharmaceutical ingredients (APIs). In particular, we focus on the application of the catalytic systems for Suzuki-Miyaura cross-coupling reactions, which is the key step in the synthesis of the targeted APIs valsartan and sacubitril...
2018: Beilstein Journal of Organic Chemistry
Alisa Palaveniene, Volodymyr Harkavenko, Vitalina Kharchenko, Povilas Daugela, Mindaugas Pranskunas, Gintaras Juodzbalys, Nataliya Babenko, Jolanta Liesiene
The use of synthetic materials for biomedical applications still presents issues owing to the potential for unfavourable safety characteristics. Currently, there is increasing interest in using natural, marine-derived raw materials for bone tissue engineering. In our study, the endoskeleton of the mollusc Sepia, i.e. cuttlebone (CB), was used with regenerated cellulose (RC) to prepare three-dimensional composite bone grafts. CB microparticles were mechanically immobilised within a cellulose gel, resulting in a macroporous structure upon lyophilisation...
April 3, 2018: Marine Biotechnology
Kan-Na Tomioku, Mikiko Shigekuni, Hiroki Hayashi, Akane Yoshida, Taiki Futagami, Hisanori Tamaki, Kenji Tanabe, Akikazu Fujita
In budding yeast Saccharomyces cerevisiae, PtdIns(4)P serves as an essential signalling molecule in the Golgi complex, endosomal system, and plasma membrane, where it is involved in the control of multiple cellular functions via direct interactions with PtdIns(4)P-binding proteins. To analyse the distribution of PtdIns(4)P in yeast cells at a nanoscale level, we employed an electron microscopy technique that specifically labels PtdIns(4)P on the freeze-fracture replica of the yeast membrane. This method minimizes the possibility of artificial perturbation, because molecules in the membrane are physically immobilised in situ...
March 27, 2018: European Journal of Cell Biology
Sana Ullah, Fadi Hamade, Urte Bubniene, Johan Engblom, Arunas Ramanavicius, Almira Ramanaviciene, Tautgirdas Ruzgas
Pig ear skin membrane-covered glucose biosensor based on oxygen electrode has been assessed as a tool to evaluate glucose penetration through skin in-vitro. For this, glucose oxidase (GOx) was immobilised on oxygen electrode and covered with the skin membrane. Exposing this electrode to the solution of glucose resulted in glucose penetration though skin membrane, its oxidation catalysed by GOx, consumption of O2 and decrease of the current of the oxygen electrode. By processing the biosensor responses to glucose, we found that glucose penetration through 250 µm thick skin membrane is slow; 90% of steady-state current response was reached in 32( ± 22) min...
March 22, 2018: Biosensors & Bioelectronics
C Taylor, J Parker, J Stratford, M Warren
INTRODUCTION: Although all systematic and random positional setup errors can be corrected for in entirety during on-line image-guided radiotherapy, the use of a specified action level, below which no correction occurs, is also an option. The following service evaluation aimed to investigate the use of this 3 mm action level for on-line image assessment and correction (online, systematic set-up error and weekly evaluation) for lower extremity sarcoma, and understand the impact on imaging frequency and patient positioning error within one cancer centre...
May 2018: Radiography
Antonio Carlos Moscon, Ana Luiza Cabrera Martimbianco, Aires Duarte Junior, Guilherme Conforto Gracitelli
We present the case of a 40-year-old man who suffered an isolated proximal tibiofibular dislocation of the left knee after a trauma during a soccer game. Physical examination and radiographic imaging revealed an anterolateral dislocation of the proximal fibula. The diagnosis was confirmed by MRI. The treatment choice was open reduction and internal fixation under direct visualisation using flexible and permanent internal fixation. Postoperative treatment includes knee immobilisation during the first week, and partial weight was allowed for 2 weeks progressing to full weight bearing over 4 weeks...
March 30, 2018: BMJ Case Reports
Tim D Nalder, Ivan Kurtovic, Colin J Barrow, Susan N Marshall
The aim of this work was to develop a simple and accurate protocol to measure the functional active site concentration of lipases immobilised on highly hydrophobic supports. We used the potent lipase inhibitor methyl 4-methylumbelliferyl hexylphosphonate to titrate the active sites of Candida rugosa lipase (CrL) bound to three highly hydrophobic supports: octadecyl methacrylate (C18), divinylbenzene crosslinked methacrylate (DVB) and styrene. The method uses correction curves to take into account the binding of the fluorophore (4-methylumbelliferone, 4-MU) by the support materials...
June 2018: Enzyme and Microbial Technology
J D Metaizeau, D Denis
Leg fractures are common and further increasing in prevalence in paediatric patients. The diagnosis is readily made in most cases. Choosing the best treatment is the main issue. Non-operative treatment is the reference standard for non-displaced or reducible and stable fractures but requires considerable expertise and close monitoring, as well as an immobilisation period that far exceeds 3 months in many cases. Some surgical teams therefore offer elastic stable intramedullary nailing (ESIN) as an alternative to children who do not want to be immobilised for several months...
March 27, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Dawid Aleksandrowicz, Andrzej Wieczorek, Tomasz Gaszyński
No abstract text is available yet for this article.
May 2018: European Journal of Anaesthesiology
Richard Mayne, James Whiting, Andrew Adamatzky
The nanotechnology revolution has allowed us to speculate on the possibility of hybridising nanoscale materials with live substrates, yet significant doubt still remains pertaining to the effects of nanomaterials on biological matter. In this investigation, we cultivate the ciliated protistic pond-dwelling microorganism Paramecium caudatum in the presence of excessive quantities of magnetite nanoparticles in order to deduce potential beneficial applications for this technique, as well as observe any deleterious effects on the organisms' health...
2018: BioNanoScience
Fei Wang, Zhengtao Shen, Abir Al-Tabbaa
The leaching performance of stabilised/solidified contaminated model soil was studied to investigate the benefit of stabilisation/solidification treatment using novel binders over conventional binders. Different combinations of Portland cement (PC), ground granulated blast-furnace slag (GGBS), pulverised fly ash (PFA), and magnesia (MgO) were used and grouped into PC-based and MgO-based binders. A semi-dynamic leaching test was used, where the cumulative releases of Zn, Cu, Ni, Pb, Ca, and Mg were measured and the effective diffusion coefficients (De) and the leachability indices (LX) were calculated...
March 28, 2018: Environmental Science and Pollution Research International
Alexander Kuznetsov, Natalia Komarova, Maria Andrianova, Vitaliy Grudtsov, Evgeniy Kuznetsov
An aptamer for vanillin was obtained and then used for the development of an aptasensor based on an ion-sensitive field-effect transistor (ISFET). This aptamer (a single-stranded DNA;ssDNA) was selected using the Capture-SELEX protocol, which suites well for selection of aptamers to small molecules. Among six aptamer candidates, the aptamer Van_74 with the highest affinity for vanillin was chosen (elution of 35% of the aptamer from a solid support in the presence of 2 mM of vanillin). Van_74 was characterized using nondenaturating PAGE of washouts from magnetic beads...
December 2, 2017: Mikrochimica Acta
Shirley Jf Collocott, Edel Kelly, Richard F Ellis
Introduction: Early mobilisation protocols after repair of extensor tendons in zone V and VI provide better outcomes than immobilisation protocols. This systematic review investigated different early active mobilisation protocols used after extensor tendon repair in zone V and VI. The purpose was to determine whether any one early active mobilisation protocol provides superior results. Methods: An extensive literature search was conducted to identify articles investigating the outcomes of early active mobilisation protocols after extensor tendon repair in zone V and VI...
March 2018: Hand Therapy
Dhanasekaran Sakthivel, Jaclyn Swan, Sarah Preston, M D Shakif-Azam, Pierre Faou, Yaqing Jiao, Rachael Downs, Harinda Rajapaksha, Robin Gasser, David Piedrafita, Travis Beddoe
Haemonchus contortus is the most pathogenic nematode of small ruminants. Infection in sheep and goats results in anaemia that decreases animal productivity and can ultimately cause death. The involvement of ruminant-specific galectin-11 (LGALS-11) and galectin-14 (LGALS-14) has been postulated to play important roles in protective immune responses against parasitic infection; however, their ligands are unknown. In the current study, LGALS-11 and LGALS-14 ligands in H. contortus were identified from larval (L4) and adult parasitic stages extracts using immobilised LGALS-11 and LGALS-14 affinity column chromatography and mass spectrometry...
2018: PeerJ
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