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https://www.readbyqxmd.com/read/28106352/a-year-in-review-in-minerva-anestesiologica-2016-critical-care-experimental-and-clinical-studies
#1
Franco Cavaliere, Guillermo M Albaiceta, Gianni Biancofiore, Elena Bignami, Edoardo DE Robertis, Alberto Giannini, Salvatore Grasso, Sabino Scolletta, Peter Spieth, Fabio S Taccone, Pierpaolo Terragni
No abstract text is available yet for this article.
January 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28101307/review-and-recommendations-on-management-of-adult-female-thalassemia-patients-with-hypogonadism-based-on-literature-review-and-experience-of-icet-a-network-specialists
#2
REVIEW
Vincenzo De Sanctis, Ashraf T Soliman, Heba Elsedfy, Alice Albu, Soad Al Jaouni, Salvatore Anastasi, Maria Grazia Bisconte, Duran Canatan, Soteroula Christou, Shahina Daar, Salvatore Di Maio, Mohamed El Kholy, Doaa Khater, Mohamed Elshinawy, Yurdanur Kilinc, Roberto Mattei, Hala H Mosli, Alessandra Quota, Maria Grazia Roberti, Praveen Sobti, Saif Al Yaarubi, Saveria Canpisi, Christos Kattamis
BACKGROUND: Multi-transfused thalassemia major (TM) patients frequently develop severe endocrine complications, mainly due to iron overload, anemia, and chronic liver disease, which require prompt diagnosis, treatment and follow-up by specialists. The most common endocrine complication documented is hypogonadotropic hypogonadism which increases with age and associated comorbidities. It is thus important for physicians to have a clear understanding of the pathophysiology and management of this disorder...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28077504/influence-of-history-of-cannabis-smoking-in-selected-donors-on-the-outcomes-of-lung-transplantation
#3
Prashant N Mohite, Mohamed Zeriouh, Diana G Sáez, Aron-Frederik Popov, Anton Sabashnikov, Bartlomiej Zych, Ashok Padukone, Levente Fazekas, Olga Ananiadou, Fabio De Robertis, Simona Soresi, Anna Reed, Martin Carby, André R Simon
OBJECTIVES: Cannabis is the most commonly abused illicit drug and the smokers are at the risk of lung infections, bullous emphysema and lung cancer. However, no evidence about the outcomes of lung transplantation (LTx) utilizing the lungs from such donors is available in the literature. METHODS: We retrospectively analysed lung 'organ offers' and LTx at our centre between January 2007 and November 2013. The outcomes of LTx utilizing lungs from donors with a history of cannabis smoking were compared with the outcomes of those with no such history using unadjusted model as well as propensity score matching...
January 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28068360/exploring-serum-levels-of-brain-derived-neurotrophic-factor-and-nerve-growth-factor-across-glaucoma-stages
#4
Francesco Oddone, Gloria Roberti, Alessandra Micera, Anna Busanello, Stefano Bonini, Luciano Quaranta, Luca Agnifili, Gianluca Manni
PURPOSE: To investigate the serum levels of Brain Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in patients affected by primary open angle glaucoma with a wide spectrum of disease severity compared to healthy controls and to explore their relationship with morphological and functional glaucoma parameters. MATERIALS AND METHODS: 45 patients affected by glaucoma at different stages and 15 age-matched healthy control subjects underwent visual field testing, peripapillary retinal nerve fibre layer thickness measurement using Spectral Domain Optical Coherence Tomography and blood collection for both neurotrophins detection by Enzyme-Linked Immunosorbent Assay...
2017: PloS One
https://www.readbyqxmd.com/read/28064079/tacrine-resveratrol-fused-hybrids-as-multi-target-directed-ligands-against-alzheimer-s-disease
#5
Jakub Jeřábek, Elisa Uliassi, Laura Guidotti, Jan Korábečný, Ondřej Soukup, Vendula Sepsova, Martina Hrabinova, Kamil Kuča, Manuela Bartolini, Luis Emiliano Peña-Altamira, Sabrina Petralla, Barbara Monti, Marinella Roberti, Maria Laura Bolognesi
Multi-target drug discovery is one of the most followed approaches in the active central nervous system (CNS) therapeutic area, especially in the search for new drugs against Alzheimer's disease (AD). This is because innovative multi-target-directed ligands (MTDLs) could more adequately address the complexity of this pathological condition. In a continuation of our efforts aimed at a new series of anti-AD MTDLs, we combined the structural features of the cholinesterase inhibitor drug tacrine with that of resveratrol, which is known for its purported antioxidant and anti-neuroinflammatory activities...
December 26, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28040358/bladder-endometriosis-a-systematic-review-of-pathogenesis-diagnosis-treatment-impact-on-fertility-and-risk-of-malignant-transformation
#6
REVIEW
Umberto Leone Roberti Maggiore, Simone Ferrero, Massimo Candiani, Edgardo Somigliana, Paola Viganò, Paolo Vercellini
CONTEXT: The bladder is the most common site affected in urinary tract endometriosis. There is controversy regarding the pathogenesis, clinical management (diagnosis and treatment), impact on fertility, and risk of malignant transformation of bladder endometriosis (BE). OBJECTIVE: To systematically evaluate evidence regarding the pathogenesis, diagnosis, medical and surgical treatment, impact on female fertility, and risk of malignant transformation of BE. EVIDENCE ACQUISITION: A systematic review of PubMed/Medline from inception until October 2016 was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement and was registered in the PROSPERO registry (www...
December 28, 2016: European Urology
https://www.readbyqxmd.com/read/28039759/human-papillomavirus-hpv-persistence-and-hpv-31-predict-the-risk-of-recurrence-in-high-grade-vaginal-intraepithelial-neoplasia
#7
Giorgio Bogani, Fabio Martinelli, Antonino Ditto, Francesca Taverna, Claudia Lombardo, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Caterina Fontanella, Ilaria Sabatucci, Chiara Borghi, Dario Recalcati, Alice Indini, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: High-grade vaginal intraepithelial neoplasia (vaginal HSIL) represents an uncommon entity. Here, we sought to identify predictors for recurrence and risk factor for developing genital cancers after primary treatment for vaginal HSIL. METHODS: Data of consecutive 5104 women who had human papillomavirus (HPV) DNA test were searched for identify women with histological confirmed vaginal HSIL. Disease-free interval and the risk of developing HPV-related gynecological cancers were assessed using Kaplan-Meier and Cox proportional hazard models...
December 23, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28038726/comparison-of-outcomes-of-coronary-artery-bypass-grafting-using-internal-mammary-graft-versus-percutaneous-coronary-intervention-for-isolated-proximal-left-anterior-descending-narrowing
#8
M Bilal Iqbal, Charles Ilsley, Fabio De Robertis, Rebecca Lane, Tito Kabir, Toufan Bahrami, Andre Simon, Aron Popov, Mohamed Amrani, Miles C Dalby, Mark Mason, Richard Grocott-Mason, Robert D Smith, Shahzad G Raja
There are limited contemporary studies comparing coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for isolated proximal left anterior descending (LAD) disease. Increasing stent length and decreasing stent diameters are associated with increased risk of restenosis and adverse outcomes after PCI. Whether these parameters influence outcomes when comparing CABG and PCI is unclear. We compared CABG and PCI in 3,473 patients who underwent revascularization for isolated proximal LAD disease from 2004 to 2015 at Harefield Hospital, UK; 3,078 patients (89%) had PCI and 384 patients had CABG (11%)...
December 2, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27956791/percutaneous-ablation-of-pancreatic-cancer
#9
EDITORIAL
Mirko D'Onofrio, Valentina Ciaravino, Riccardo De Robertis, Emilio Barbi, Roberto Salvia, Roberto Girelli, Salvatore Paiella, Camilla Gasparini, Nicolò Cardobi, Claudio Bassi
Pancreatic ductal adenocarcinoma is a highly aggressive tumor with an overall 5-year survival rate of less than 5%. Prognosis and treatment depend on whether the tumor is resectable or not, which mostly depends on how quickly the diagnosis is made. Chemotherapy and radiotherapy can be both used in cases of non-resectable pancreatic cancer. In cases of pancreatic neoplasm that is locally advanced, non-resectable, but non-metastatic, it is possible to apply percutaneous treatments that are able to induce tumor cytoreduction...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27942790/is-mirabegron-equally-as-effective-when-used-as-first-or-second-line-therapy-in-women-with-overactive-bladder
#10
Maurizio Serati, Umberto Leone Roberti Maggiore, Paola Sorice, Simona Cantaluppi, Enrico Finazzi Agrò, Fabio Ghezzi
INTRODUCTION AND HYPOTHESIS: No previous studies have investigated the efficacy of mirabegron 50 mg as the first-line therapy in OAB patients. Hence, the primary objective of this study was to evaluate the efficacy of mirabegron in treatment-naive patients in comparison with those who had discontinued antimuscarinic therapy because of insufficient efficacy. METHODS: All consecutive women who had pure OAB symptoms (including urgency with or without urgency incontinence and frequency) for at least 3 months were considered for this study...
December 10, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27924688/susceptibility-to-vaccine-preventable-diseases-and-vaccination-adherence-among-healthcare-workers-in-italy-a-cross-sectional-survey-at-a-regional-acute-care-university-hospital-and-a-systematic-review
#11
Umberto Leone Roberti Maggiore, Carolina Scala, Alessandra Toletone, Nicoletta Debarbieri, Mauro Perria, Beatrice D'Amico, Alfredo Montecucco, Mariano Martini, Guglielmo Dini, Paolo Durando
Healthcare Workers (HCWs) have an increased risk both to acquire and to spread vaccine preventable diseases (VPDs) both to their colleagues and, especially, to vulnerable patients. The prevention of occupational hazards among HCWs is based on proper adoption of the standard and additional precautions, immunizations, and secondary preventive measures, such as post-exposure prophylaxis. Moreover, HCWs are often referred to as the most trusted source of vaccine-related information for their patients. In the present article, we report the findings of a cross-sectional study investigating the compliance to vaccinations among HCWs employed at the Obstetric Unit of a regional acute-care University Hospital in Northern Italy...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27906872/role-of-combined-68ga-dotatoc-and-18f-fdg-positron-emission-tomography-computed-tomography-in-the-diagnostic-workup-of-pancreas-neuroendocrine-tumors-implications-for-managing-surgical-decisions
#12
Sara Cingarlini, Silvia Ortolani, Matteo Salgarello, Giovanni Butturini, Anna Malpaga, Veronica Malfatti, Mirko DʼOnofrio, Maria Vittoria Davì, Paola Vallerio, Andrea Ruzzenente, Paola Capelli, Elia Citton, Elisabetta Grego, Chiara Trentin, Riccardo De Robertis, Aldo Scarpa, Claudio Bassi, Giampaolo Tortora
OBJECTIVES: Ga-DOTATOC (Ga) positron emission tomography (PET)/computed tomography (CT) is recommended in the workup of pancreas neuroendocrine tumors (PanNETs); evidence suggests that F-FDG (F) PET/CT can also provide prognostic information. Aims of this study were to assess the role of combined Ga- and F-PET/CT in the evaluation of grade (G) 1-2 PanNETs and to test the correlation between F-PET/CT positivity and tumor grade. METHODS: Preoperative Ga- and F-PET/CT of 35 patients with surgically resected G1-2 PanNETs were evaluated...
January 2017: Pancreas
https://www.readbyqxmd.com/read/27896229/effect-of-%C3%AE-2-adrenergic-agonists-and-antagonists-on-cytokine-release-from-human-lung-macrophages-cultured-in-vitro
#13
O Piazza, R I Staiano, E De Robertis, G Conti, V Di Crescenzo, S Loffredo, G Marone, G Zito Marinosci, M M Cataldi
The most trusted hypothesis to explain how α2-adrenergic agonists may preserve pulmonary functions in critically ill patients is that they directly act on macrophages by interfering with an autocrine/paracrine adrenergic system that controls cytokine release through locally synthetized noradrenaline and α1- and α2-adrenoreceptors. We tested this hypothesis in primary cultures of resident macrophages from human lung (HLMs). HLMs were isolated by centrifugation on percoll gradients from macroscopically healthy human lung tissue obtained from four different patients at the time of lung resection for cancer...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27890797/3-bromopyruvate-treatment-induces-alterations-of-metabolic-and-stress-related-pathways-in-glioblastoma-cells
#14
Davide Chiasserini, Magdalena Davidescu, Pier Luigi Orvietani, Federica Susta, Lara Macchioni, Maya Petricciuolo, Emilia Castigli, Rita Roberti, Luciano Binaglia, Lanfranco Corazzi
: Glioblastoma (GBM) is the most common and aggressive brain tumour of adults. The metabolic phenotype of GBM cells is highly dependent on glycolysis; therefore, therapeutic strategies aimed at interfering with glycolytic pathways are under consideration. 3-Bromopyruvate (3BP) is a potent antiglycolytic agent, with a variety of targets and possible effects on global cell metabolism. Here we analyzed the changes in protein expression on a GBM cell line (GL15 cells) caused by 3BP treatment using a global proteomic approach...
January 30, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27888705/chemotherapy-related-leukopenia-as-a-biomarker-predicting-survival-outcomes-in-locally-advanced-cervical-cancer
#15
Giorgio Bogani, Ilaria Sabatucci, Giuseppa Maltese, Francesca Lecce, Mauro Signorelli, Fabio Martinelli, Valentina Chiappa, Alice Indini, Umberto Leone Roberti Maggiore, Chiara Borghi, Giovanni Fucà, Antonino Ditto, Francesco Raspagliesi, Domenica Lorusso
OBJECTIVE: To investigate the impact of hematologic toxicity and leukopenia in locally advanced cervical cancer patients undergoing neoadjuvant chemotherapy (NACT). STUDY DESIGN: Data of consecutive patients undergoing platinum-based NACT followed by surgery were retrospectively searched in order to evaluate the impact of chemotherapy-related toxicity on survival outcomes. Toxicity was graded per the Common Terminology Criteria for Adverse Events (CTCAEv.4.03). Survival outcomes were evaluated using Kaplan-Meir and Cox hazard models...
January 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27867855/laparoscopic-approach-for-gonadectomy-in-pediatric-patients-with-intersex-disorders
#16
REVIEW
Andres Calvo, Maria Escolino, Alessandro Settimi, Agnese Roberti, Maria Grazia Caprio, Ciro Esposito
The birth of a child with a disorder of sex development (DSD) prompts a long-term management strategy that involves a myriad of professionals working with the family. There has been progress in diagnosis, surgical techniques and in understanding psychosocial issues related to this condition. However, since these kinds of disorders are rare and have many anatomical variations, individual care is necessary, especially regarding surgical management. Gonadectomy is indicated in a number of intersex disorders with a Y chromosome to reduce the associated risk of cancer...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27867847/retroperitoneal-and-laparoscopic-heminephrectomy-in-duplex-kidney-in-infants-and-children
#17
Ciro Esposito, Maria Escolino, Marco Castagnetti, Antonio Savanelli, Angela La Manna, Alessandra Farina, Francesco Turrà, Agnese Roberti, Alessandro Settimi, Francois Varlet, Holger Till, Jean Stephan Valla
BACKGROUND: Two main techniques are adopted to perform partial nephrectomy in children: laparoscopy and retroperitoneoscopy. The aim of this paper is to review the larger multicentric experience recently published by our group to review indications, techniques and results of both approaches. METHODS: Data of 102 patients underwent partial nephrectomy in a 5-year period using minimally invasive surgery (MIS) procedures were analyzed. Fifty-two children underwent laparoscopic partial nephrectomy (LPN), and 50 children underwent retroperitoneoscopic partial nephrectomy (RPN)...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27867844/surgical-approaches-for-varicocele-in-pediatric-patient
#18
Alejandra Parrilli, Agnese Roberti, Maria Escolino, Ciro Esposito
BACKGROUND: Varicocele represents one of the most common surgically correctible urologic anomalies in adolescent males. The best procedure for the treatment of adolescent varicocele has not been established, but with recent advances in minimal access surgery, there have been many reports praising the safety and efficacy of laparoscopy and retroperitoneoscopy for the surgical correction of varicocele in adolescent. The aim of this review is to compare the results of Palomo's technique, with retroperitoneoscopic and transperitoneoscopic approaches in adolescent, analyzing recurrence, testicular growth and complications...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27861198/digital-subtraction-of-magnetic-resonance-images-improves-detection-and-characterization-of-pancreatic-neuroendocrine-neoplasms
#19
Riccardo De Robertis, Paolo Tinazzi Martini, Sara Cingarlini, Silvia Ortolani, Giovanni Butturini, Paolo Regi, Luca Landoni, Giampaolo Tortora, Paolo Pederzoli, Mirko D'Onofrio
OBJECTIVE: The aim of this study was to evaluate the usefulness of digital image subtraction of contrast-enhanced magnetic resonance (MR) images for detection and characterization of pancreatic neuroendocrine neoplasms (PanNENs). METHODS: Magnetic resonance examinations of 50 histologically verified PanNENs were retrospectively evaluated by 2 radiologists; 50 ductal adenocarcinomas were included as a control group. Late arterial phase images and correspondent subtracted images were analyzed...
November 17, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27827510/synthesis-of-natural-urolithin-m6-a-galloflavin-mimetic-as-a-potential-inhibitor-of-lactate-dehydrogenase-a
#20
Sebastiano Rupiani, Laura Guidotti, Marcella Manerba, Lorenza Di Ianni, Elisa Giacomini, Federico Falchi, Giuseppina Di Stefano, Marinella Roberti, Maurizio Recanatini
Glycolysis is the main route for energy production in tumors. LDH-A is a key enzyme of this process and its inhibition represents an attractive strategy to hamper cancer cell metabolism. Galloflavin is a reliable LDH-A inhibitor as previously identified by us; however, its poor physicochemical properties and chemical tractability render it unsuitable for further development. Therefore, a rational design was undertaken with the aim to reproduce the pharmacophore of galloflavin on simpler, potentially more soluble and synthetic accessible scaffolds...
November 9, 2016: Organic & Biomolecular Chemistry
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