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Sara Bobisse, Raphael Genolet, Annalisa Roberti, Janos L Tanyi, Julien Racle, Brian J Stevenson, Christian Iseli, Alexandra Michel, Marie-Aude Le Bitoux, Philippe Guillaume, Julien Schmidt, Valentina Bianchi, Denarda Dangaj, Craig Fenwick, Laurent Derré, Ioannis Xenarios, Olivier Michielin, Pedro Romero, Dimitri S Monos, Vincent Zoete, David Gfeller, Lana E Kandalaft, George Coukos, Alexandre Harari
Immunotherapy directed against private tumor neo-antigens derived from non-synonymous somatic mutations is a promising strategy of personalized cancer immunotherapy. However, feasibility in low mutational load tumor types remains unknown. Comprehensive and deep analysis of circulating and tumor-infiltrating lymphocytes (TILs) for neo-epitope specific CD8+ T cells has allowed prompt identification of oligoclonal and polyfunctional such cells from most immunotherapy-naive patients with advanced epithelial ovarian cancer studied...
March 15, 2018: Nature Communications
Sabrina L Roberti, Romina Higa, Verónica White, Theresa L Powell, Thomas Jansson, Alicia Jawerbaum
STUDY QUESTION: What are the consequences of inhibiting mTOR, the mechanistic target of rapamycin, and the peroxisome proliferator activated receptor gamma (PPARγ) and PPARδ pathways in the early post-implantation period on decidual function, embryo viability and feto-placental growth in the rat? SUMMARY ANSWER: mTOR inhibition from day 7 to day 9 of pregnancy in rats caused decidual PPARγ and PPARδ upregulation on day 9 of pregnancy and resulted in embryo resorption by day 14 of pregnancy...
March 12, 2018: Molecular Human Reproduction
Antonino Ditto, Giorgio Bogani, Umberto Leone Roberti Maggiore, Fabio Martinelli, Valentina Chiappa, Carlos Lopez, Stefania Perotto, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Nerve-sparing radical hysterectomy (NSRH) was introduced with the aim to reduce pelvic dysfunctions related to conventional radical hysterectomy (RH). Here, we sought to assess the effectiveness and safety of NSRH in a relatively large number of the patients of cervical cancer (CC) patients undergoing either primary surgery or neoadjuvant chemotherapy (NACT) followed by surgery. METHODS: Outcomes of consecutive patients undergoing NSRH and of a historical cohort of patients undergoing conventional RH were retrospectively reviewed...
February 28, 2018: Journal of Gynecologic Oncology
Giorgio Bogani, Elena Tagliabue, Mauro Signorelli, Antonino Ditto, Fabio Martinelli, Valentina Chiappa, Lavinia Mosca, Ilaria Sabatucci, Umberto Leone Roberti Maggiore, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To test the applicability of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) and Memorial Sloan Kettering (MSK) criteria in predicting complete cytoreduction (CC) in patients undergoing secondary cytoreductive surgery (SCS) for recurrent ovarian cancer (ROC). METHODS: Data of consecutive patients undergoing SCS were reviewed. The Arbeitsgemeinschaft Gynäkologische Onkologie OVARian cancer study group (AGO-OVAR) and MSK criteria were retrospectively applied...
February 23, 2018: Journal of Gynecologic Oncology
L De Riccardis, A Buccolieri, M Muci, E Pitotti, F De Robertis, G Trianni, D Manno, M Maffia
Although many studies have been carried out in order to understand the implication of copper (Cu) in the pathogenesis of multiple sclerosis (MS), the exact role that this metal plays in the disease is not still clear. Because of the lack of information in this subject, the present study compared the serum and cerebrospinal (CSF) levels of copper in MS patients in respect to a control group, matched for age and sex, finding a significant increase of metal concentrations, in both biological fluids of MS subjects...
March 7, 2018: Biochimica et Biophysica Acta
Federico Cicora, Jorgelina Petroni, Javier Roberti
PURPOSE OF REVIEW: Kidney transplant recipients have an increased risk of pulmonary embolism; however, thromboprophylaxis poses a challenge as the risk of thrombosis must be balanced against the risk of bleeding. This review summarizes the evidence on whether thromboprophylaxis is required in kidney transplantation. RECENT FINDINGS: Incidence of venous thromboembolism, comprising pulmonary embolism and deep venous thrombosis, is increased in kidney transplant recipients compared to the general population, with augmented risk of death and graft loss...
February 23, 2018: Current Urology Reports
Geneviève Leduc-Robert, Wayne P Maddison
BACKGROUND: Habronattus is a diverse clade of jumping spiders with complex courtship displays and repeated evolution of Y chromosomes. A well-resolved species phylogeny would provide an important framework to study these traits, but has not yet been achieved, in part because the few genes available in past studies gave conflicting signals. Such discordant gene trees could be the result of incomplete lineage sorting (ILS) in recently diverged parts of the phylogeny, but there are indications that introgression could be a source of conflict...
February 22, 2018: BMC Evolutionary Biology
Giorgio Bogani, Umberto Leone Roberti Maggiore, Mauro Signorelli, Fabio Martinelli, Antonino Ditto, Ilaria Sabatucci, Lavinia Mosca, Domenica Lorusso, Francesco Raspagliesi
Human papillomavirus (HPV) is the most common sexually transmitted disease, worldwide. Primary prevention thorough vaccination si able to reduce the burden of HPV-related lesions. Ten years ago the Food and drug Administration (FDA) approved the first vaccine against HPV. In the last decades, growing data on safety and effectiveness have been collected. In the present review we report the current knowledge on vaccine against HPV, highlighting the current value and prospective regarding the widespread diffusion of HPV vaccines...
February 2018: Critical Reviews in Oncology/hematology
Kota Nagasaka, M Julius Hossain, M Julia Roberti, Jan Ellenberg, Toru Hirota
In the version of this Letter originally published, the authors omitted a citation of an early study demonstrating topoisomerase-II-dependent sister chromatid resolution. This reference has now been added to the reference list as reference number 28, and the relevant text has been amended as follows to include its citation: 'Resolution must reflect the removal of sister-sister contacts, and we show here that Topo-IIα-mediated release of DNA catenation plays a major role (Fig. 4), in agreement with previous findings28, whereas, surprisingly, cohesin dissociation is not strictly required (Fig...
February 12, 2018: Nature Cell Biology
Michael D SanClements, Ivan J Fernandez, Robert A Lee, Joshua A Roberti, Mary Beth Adams, Garret A Rue, Diane M McKnight
Over the last several decades dissolved organic carbon concentrations (DOC) in surface waters have increased throughout much of the northern hemisphere. Several hypotheses have been proposed regarding the drivers of this phenomenon including decreased sulfur (S) deposition working via an acidity- change mechanism. Using fluorescence spectroscopy and data from two long-term (24+ years at completion of this study) whole watershed acidification experiments, that is, the Bear Brook Watershed in Maine (BBWM) and Fernow Experimental Forest in West Virginia (FEF) allowed us to control for factors other than the acidity-change mechanism (e...
February 12, 2018: Environmental Science & Technology
Gianfranco Diletti, Giampiero Scortichini, Maria Cesarina Abete, Giovanni Binato, Luca Candeloro, Roberta Ceci, Giannina Chessa, Annamaria Conte, Alessandra Di Sandro, Mauro Esposito, Giorgio Fedrizzi, Vincenzo Ferrantelli, Enrica Ferretti, Simonetta Menotta, Valeria Nardelli, Bruno Neri, Arianna Piersanti, Francesca Roberti, Alessandro Ubaldi, Gianfranco Brambilla
The implementation of the European Union strategy for polychlorodibenzo-dioxins and -furans (PCDD/Fs), and dioxin-like polychlorobiphenyls (DL-PCBs) is determining a general reduction of their presence in the environment and in the food chain. The most important route for human exposure to these substances is food consumption and, as a consequence, a progressive decrease of their dietary intake has been observed in the last decades. In this context, it seemed worth updating the PCDD/F and DL-PCB intake estimation for the Italian population...
January 27, 2018: Science of the Total Environment
Emanuele Porru, Placido Franco, Donato Calabria, Silvia Spinozzi, Marinella Roberti, Cristiana Caliceti, Aldo Roda
Berberine (BBR) is a natural alkaloid obtained from Berberis species plants, known for its protective effects against several diseases. Among the primary BBR metabolites, berberrubine (M1) showed the highest plasma concentration but few and conflicting data are available regarding its concentration in biological fluids related to its new potential activity on vascular cells. A combined analytical approach was applied to study biodistribution of M1 in comparison with BBR. The optimization of sample clean-up combined with a fully validated HPLC-ESI-MS/MS tailored for M1 allows sufficient detectability and accuracy to be reached in the different studied organs even when administered at low dose, comparable to that assumed by human...
February 7, 2018: Analytical and Bioanalytical Chemistry
Shahzad G Raja, Charles Ilsley, Fabio De Robertis, Rebecca Lane, Tito Kabir, Toufan Bahrami, Andre Simon, Aron Popov, Miles C Dalby, Mark Mason, Richard Grocott-Mason, Robert D Smith, M Bilal Iqbal
BACKGROUND: Studies comparing coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) have largely been performed in the bare-metal stent (BMS) and first-generation drug eluting stent (F-DES) era. Second-generation DES (S-DES) have shown improved outcomes when compared to F-DES, but data comparing CABG with PCI using S-DES is limited. We compared mortality following CABG versus PCI for patients with multivessel disease and analyzed different stent types. METHODS: A total of 6,682 patients underwent multivessel revascularization at Harefield Hospital, UK...
2018: PloS One
C Scala, U Leone Roberti Maggiore, F Barra, P L Venturini, S Ferrero
INTRODUCTION: This patient preference prospective study was designed to compare patients' satisfaction in women with endometriosis treated either by an extended-cycle oral contraception (OC) or by norethindrone acetate (NETA). METHODS: This patient preference prospective study included women of reproductive age with endometriosis. Patients were submitted to one of the following 12 months' treatments: Group A, continuous oral treatment with NETA (2.5 mg/day) and Group B, a 91-day extended-cycle OC (LNG/EE 150/30 mcg for 84 days and EE 10 mcg for 7 days)...
March 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Giorgio Bogani, Francesca Taverna, Claudia Lombardo, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Lavinia Mosca, Ilaria Sabatucci, Cono Scaffa, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To assess the risk of developing high-grade cervical dysplasia among women with low-grade cervical cytology and nonvisible squamocolumnar junction (SCJ) at colposcopic examination. METHODS: Data of consecutive women with low-grade intraepithelial lesion(≤LSIL) undergoing colposcopic examination, which was unsatisfactory (due to the lack of the visualization of the entire SCJ), were retrospectively reviewed. The risk of developing high-grade cervical intraepithelial neoplasia (CIN2+) was assessed using Kaplan-Meier and Cox models...
January 1, 2018: Reproductive Sciences
D'Onofrio Mirko, Ciaravino Valentina, Cardobi Nicolò, De Robertis Riccardo, Tinazzi Martini Paolo, Girelli Roberto, Barbi Emilio, Paiella Salvatore, Marrano Enrico, Salvia Roberto, Butturini Giovanni, Pederzoli Paolo, Bassi Claudio
No abstract text is available yet for this article.
December 2017: Endoscopic Ultrasound
Bernd W Böttiger, Luca Brazzi, Edorado De Robertis, Jochen Hinkelbein, Jannicke Mellin-Olsen, Kurt Rützler, Eldar Søreide, Lorenz Theiler, Karl-Christian Thies
No abstract text is available yet for this article.
March 2018: European Journal of Anaesthesiology
Karl-Christian Thies, Edoardo De Robertis, Bernd W Böttiger, Jannicke Mellin-Olsen
No abstract text is available yet for this article.
March 2018: European Journal of Anaesthesiology
Edoardo De Robertis, Karl-Christian Thies, Bernd W Böttiger, Jannicke Mellin-Olsen
No abstract text is available yet for this article.
March 2018: European Journal of Anaesthesiology
Eldar Søreide, Jannicke Mellin-Olsen, Luca Brazzi, Edoardo De Robertis
No abstract text is available yet for this article.
March 2018: European Journal of Anaesthesiology
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