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https://www.readbyqxmd.com/read/29774729/intermediate-care-unit-an-efficient-and-flexible-facility-or-a-limbo-between-icu-and-ward
#1
Edoardo De Robertis
No abstract text is available yet for this article.
May 15, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29773710/arginine-methylation-is-required-for-canonical-wnt-signaling-and-endolysosomal-trafficking
#2
Lauren V Albrecht, Diego Ploper, Nydia Tejeda-Muñoz, Edward M De Robertis
Arginine methylation has emerged as a widespread and reversible protein modification with the potential to regulate a multitude of cellular processes, but its function is poorly understood. Endolysosomes play an important role in Wnt signaling, in which glycogen synthase kinase 3 (GSK3) becomes sequestered inside multivesicular bodies (MVBs) by the process known as microautophagy, causing the stabilization of many proteins. Up to 20% of cellular proteins contain three or more consecutive putative GSK3 sites, and of these 33% also contain methylarginine (meArg) modifications...
May 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29759566/role-of-bevacizumab-in-uterine-leiomyosarcoma
#3
REVIEW
Giorgio Bogani, Antonino Ditto, Fabio Martineli, Mauro Signorelli, Valentina Chiappa, Caterina Fonatella, Roberta Sanfilippo, Umberto Leone Roberti Maggiore, Simone Ferrero, Domenica Lorusso, Francesco Raspagliesi
In the recent years, angiogenetic inhibitors have emerged for the treatment of several malignancies. In particular, bevacizumab has proved to be effective in many types of cancers (including sarcoma), but the limitations of antiangiogenic therapy have been shown in practice. Here, we sought to review the current evidence on the role and efficacy of bevacizumab in patients affected by uterine leiomyosarcoma. On April 2017, Literature was searched in order to identify studies reporting outcomes of patients affected either by early stage or advanced/recurred uterine leiomyosarcoma undergoing treatment with bevacizumab, alone or in combination with other chemotherapeutic regimens...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29756652/laser-treatment-for-women-with-high-grade-vaginal-intraepithelial-neoplasia-a-propensity-matched-analysis-on-the-efficacy-of-ablative-versus-excisional-procedures
#4
Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Lavinia Mosca, Valentina Chiappa, Diego Rossetti, Umberto Leone Roberti Maggiore, Ilaria Sabatrucci, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To investigate the long-term effectiveness of LASER treatment in women affected by high-grade vaginal intra-epithelial neoplasia. METHODS: Data of consecutive women treated for high-grade vaginal intra-epithelial neoplasia were retrieved. Efficacy and long-term effectiveness of ablative and excisional procedures were tested using a propensity-matched algorithm. Risk of recurrence over the time was assessed using Kaplan-Meier and Cox models. RESULTS: Overall, 204 patients met the inclusion criteria...
May 14, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29756616/treatment-of-cholesteatoma-with-intact-ossicular-chain-anatomic-and-functional-results
#5
V Pontillo, F Barbara, V DE Robertis, N Quaranta
In case of cholesteatoma with intact ossicular chain, the primary aims of surgery are complete removal of the cholesteatoma matrix and reconstruction of a dry and safe middle ear; if possible, ossicular chain continuity and therefore the preoperative hearing must be preserved. The aim of this retrospective study is to present the experience of the U.O.C. Otorinolaringoiatria Universitaria of University of Bari "Aldo Moro" in treatment of intact ossicular chain cholesteatoma with Bondy modified radical mastoidectomy (BMRM) and canal wall up tympanoplasty (CWUT)...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29754033/abdominoplasty-with-scarpa-fascia-preservation-case-report
#6
Antonio Iannelli, Francesco Ciancio, Paolo Annoscia, Michelangelo Vestita, Rosario Emanuele Perrotta, Giuseppe Giudice, Michele De Robertis
INTRODUCTION: Abdominoplasty is one of the most performed operations in Plastic Surgery in the world. Postoperative seroma is one of the most frequently cited complications in literature. The aim of this study is to propose our experience with abdominoplasty with Scarpa Fascia preservationand compare it with recent scientific literature. PRESENTATION OF CASE: We present the case of a 55-year-old woman underwent bariatric surgery in 2014, after which she lost 55 kg of weight...
May 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29742219/assessment-of-delirium-using-the-pre-deliric-model-in-an-intensive-care-unit-in-argentina
#7
Fernando Ariel Sosa, Javier Roberti, Margarita Tovar Franco, María Mercedes Kleinert, Agustina Risso Patrón, Javier Osatnik
OBJECTIVE: To describe the incidence of and risk factors for delirium in the intensive care unit of a tertiary care teaching hospital in Argentina and to conduct the first non-European study exploring the performance of the PREdiction of DELIRium in ICu patients (PRE-DELIRIC) model. METHODS: Prospective observational study in a 20-bed intensive care unit of a tertiary care teaching hospital in Buenos Aires, Argentina. The PRE-DELIRIC model was applied to 178 consecutive patients within 24 hours of admission to the intensive care unit; delirium was assessed with the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)...
March 2018: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29734319/-a-critical-analysis-of-the-degree-of-care-humanization-in-the-hospitals-of-the-provincia-romana-san-giovanni-di-dio-fatebenefratelli-fbf
#8
Flavia Verginelli, Rosaria Gallo, Annalisa Teti, Claudia Franco, Patrizia Piscioneri, Giovanni Pimpinella, Rosalia Fiore, Angela Primavera, Adriana Sorrentino, Giovanni Guglielmucci, Michele Venditti, Alberto Carbone, Mariateresa Iannuzzo, Giampiero Seroni, Pietro Civello, Maria Cardarelli, Giovanni Roberti
In the Hospitals of the Ordine della Provincia Romana San Giovanni di Dio Fatebenefratelli (FBF) (consisting of four hospitals located in three Italian regions) Patient Centeredness has always been considered a central point. In 2015, the Central Hospitals' Health Direction decided to use a check-list for the evaluation of the degree of Patient Centered Care Facilities, drawn up by the National Agency for Regional Health Services (Age.Na.S) during the 2010 Research Project "Experimentation and transfer of organizational empowerment models for evaluating and improving the quality of health services...
January 2018: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29730774/in-flight-cardiac-arrest-and-in-flight-cardiopulmonary-resuscitation-during-commercial-air-travel-consensus-statement-and-supplementary-treatment-guideline-from-the-german-society-of-aerospace-medicine-dglrm
#9
Jochen Hinkelbein, Lennert Böhm, Stefan Braunecker, Harald V Genzwürker, Steffen Kalina, Fabrizio Cirillo, Matthieu Komorowski, Andreas Hohn, Jörg Siedenburg, Michael Bernhard, Ilse Janicke, Christoph Adler, Stefanie Jansen, Eckard Glaser, Pawel Krawczyk, Mirko Miesen, Janusz Andres, Edoardo De Robertis, Christopher Neuhaus
By the end of the year 2016, approximately 3 billion people worldwide travelled by commercial air transport. Between 1 out of 14,000 and 1 out of 50,000 passengers will experience acute medical problems/emergencies during a flight (i.e., in-flight medical emergency). Cardiac arrest accounts for 0.3% of all in-flight medical emergencies. So far, no specific guideline exists for the management and treatment of in-flight cardiac arrest (IFCA). A task force with clinical and investigational expertise in aviation, aviation medicine, and emergency medicine was created to develop a consensus based on scientific evidence and compiled a guideline for the management and treatment of in-flight cardiac arrests...
May 5, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29709409/screening-surveillance-programs-for-pancreatic-cancer-in-familial-high-risk-individuals-a-systematic-review-and-proportion-meta-analysis-of-screening-results
#10
REVIEW
Salvatore Paiella, Roberto Salvia, Matteo De Pastena, Tommaso Pollini, Luca Casetti, Luca Landoni, Alessandro Esposito, Giovanni Marchegiani, Giuseppe Malleo, Giulia De Marchi, Aldo Scarpa, Mirko D'Onofrio, Riccardo De Robertis, Teresa Lucia Pan, Laura Maggino, Stefano Andrianello, Erica Secchettin, Deborah Bonamini, Davide Melisi, Massimiliano Tuveri, Claudio Bassi
BACKGROUND/OBJECTIVES: Screening/surveillance programs for pancreatic cancer (PC) in familial high-risk individuals (FPC-HRI) have been widely reported, but their merits remain unclear. The data reported so far are heterogeneous-especially in terms of screening yield. We performed a systematic review and meta-analysis of currently available data coming from screening/surveillance programs to evaluate the proportion of screening goal achievement (SGA), overall surgery and unnecessary surgery...
April 10, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29708905/pre-operative-evaluation-of-adults-undergoing-elective-noncardiac-surgery-updated-guideline-from-the-european-society-of-anaesthesiology
#11
Stefan De Hert, Sven Staender, Gerhard Fritsch, Jochen Hinkelbein, Arash Afshari, Gabriella Bettelli, Matthias Bock, Michelle S Chew, Mark Coburn, Edoardo De Robertis, Hendrik Drinhaus, Aarne Feldheiser, Götz Geldner, Daniel Lahner, Andrius Macas, Christopher Neuhaus, Simon Rauch, Maria Angeles Santos-Ampuero, Maurizio Solca, Nima Tanha, Vilma Traskaite, Gernot Wagner, Frank Wappler
: The purpose of this update of the European Society of Anaesthesiology (ESA) guidelines on the pre-operative evaluation of the adult undergoing noncardiac surgery is to present recommendations based on the available relevant clinical evidence. Well performed randomised studies on the topic are limited and therefore many recommendations rely to a large extent on expert opinion and may need to be adapted specifically to the healthcare systems of individual countries. This article aims to provide an overview of current knowledge on the subject with an assessment of the quality of the evidence in order to allow anaesthesiologists all over Europe to integrate - wherever possible - this knowledge into daily patient care...
June 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29690291/two-new-species-of-freshwater-crayfish-of-the-genus-faxonius-decapoda-cambaridae-from-the-ozark-highlands-of-arkansas-and-missouri
#12
James W Jr Fetzner, Christopher A Taylor
Two new species of freshwater crayfish are described from the Ozarks Plateau of northern Arkansas and southern Missouri. Both species are restricted to the mainstem of rocky streams that are at least fourth-order or greater in size. Recent genetic and morphological investigations of the coldwater crayfish, Faxonius eupunctus Williams, 1952, indicated that it was actually composed of several undescribed species. Faxonius eupunctus is herein restricted to just the Eleven Point River system. Faxonius roberti, new species is found in the mainstem of the Spring and Strawberry river systems in northern Arkansas...
March 22, 2018: Zootaxa
https://www.readbyqxmd.com/read/29687335/prospective-randomized-single-masked-parallel-study-exploring-the-effects-of-a-preservative-free-ophthalmic-solution-containing-hyaluronic-acid-0-4-and-taurine-0-5-on-the-ocular-surface-of-glaucoma-patients-under-multiple-long-term-topical-hypotensive-therapy
#13
Gloria Roberti, Luca Agnifili, Francesca Berardo, Ivano Riva, Michele Figus, Gianluca Manni, Luciano Quaranta, Francesco Oddone
INTRODUCTION: To compare the effects of a preservative-free (PF) ophthalmic solution containing hyaluronic acid (HA) 0.4% and taurine (TAU) 0.5% with those of a PF ophthalmic solution containing HA 0.2% on ocular surface signs, symptoms, and morphological parameters in glaucoma patients under multiple long-term topical hypotensive therapy. METHODS: Eligible patients underwent evaluation of ocular surface parameters by ocular surface disease index (OSDI) and glaucoma symptom scale (GSS) questionnaires, breakup time test (BUT), Schirmer I test, corneal and conjunctival staining (Oxford scale), and conjunctival in vivo confocal microscopy (Heidelberg Retina Tomograph 3, Heidelberg Engineering GmbH, Heidelberg, Germany)...
April 23, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29686106/embryonic-regeneration-by-relocalization-of-the-spemann-organizer-during-twinning-in-xenopus
#14
Yuki Moriyama, Edward M De Robertis
The formation of identical twins from a single egg has fascinated developmental biologists for a very long time. Previous work had shown that Xenopus blastulae bisected along the dorsal-ventral (D-V) midline (i.e., the sagittal plane) could generate twins but at very low frequencies. Here, we have improved this method by using an eyelash knife and changing saline solutions, reaching frequencies of twinning of 50% or more. This allowed mechanistic analysis of the twinning process. We unexpectedly observed that the epidermis of the resulting twins was asymmetrically pigmented at the tailbud stage of regenerating tadpoles...
April 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29683876/factors-predictive-of-90-day-morbidity-readmission-and-costs-in-patients-undergoing-pelvic-exenteration
#15
Giorgio Bogani, Mauro Signorelli, Antonino Ditto, Fabio Martinelli, Jvan Casarin, Lavinia Mosca, Umberto Leone Roberti Maggiore, Valentina Chiappa, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Pelvic exenteration for recurrent gynecological malignancies is characterized by a high rate of severe complications. Factors predictive of morbidity, readmission, and cost were analyzed. METHODS: Data of consecutive patients undergoing pelvic exenteration between January 2007 and December 2016 were prospectively evaluated. RESULTS: Fifty-eight patients were included in the analysis. Anterior, posterior, and total exenterations were executed in 39 (67%), 9 (16%), and 10 (17%) patients, respectively...
April 21, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29683399/seroprevalence-of-dengue-virus-west-nile-virus-chikungunya-virus-and-zika-virus-in-international-travelers-attending-a-travel-and-migration-center-in-2015-2017-southern-italy
#16
Daniela Loconsole, Angela Metallo, Anna Lisa De Robertis, Anna Morea, Michele Quarto, Maria Chironna
International travelers to areas endemic for vector-borne diseases (VBDs) may be at risk of contracting and spreading these diseases. The aim of this study was to evaluate the prevalence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies that are specific for Dengue Virus (DV), West Nile Virus (WNV), Chikungunya Virus (CHIKV), or Zika Virus (ZV) in a cohort of international travelers. The study enrolled travelers who attended the Travel Medicine and Migration outpatient service of Local Health Unit of Bari, Italy, in March 2015-June 2017 for counseling and vaccine prophylaxis before travel...
April 23, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29675501/does-donor-age-of-nonirradiated-achilles-tendon-allograft-influence-mid-term-results-of-revision-acl-reconstruction
#17
Stefano Zaffagnini, Tommaso Roberti di Sarsina, Tommaso Bonanzinga, Marco Nitri, Luca Macchiarola, Federico Stefanelli, Gianandrea Lucidi, Alberto Grassi
Purpose  The purpose of the present study was to investigate if the donor age of nonirradiated Achilles tendon allograft could influence the clinical results of revision anterior cruciate ligament (ACL) reconstruction. Methods  All patients that underwent ACL revision between 2004 and 2008 with at least 4 years of follow-up were included. For all the patients that met the inclusion criteria, the age of the graft donor was obtained from the tissue bank. Lysholm score was administered to patients that met inclusion criteria...
March 2018: Joints
https://www.readbyqxmd.com/read/29658896/safety-and-quality-of-procedural-sedation-and-analgesia-practice-for-adult-patients-throughout-europe-a-step-forward
#18
Edoardo De Robertis, Dan Longrois, Thomas Fuchs-Buder
No abstract text is available yet for this article.
January 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29650408/normothermic-ex-vivo-preservation-with-the-portable-organ-care-system-lung-device-for-bilateral-lung-transplantation-inspire-a-randomised-open-label-non-inferiority-phase-3-study
#19
Gregor Warnecke, Dirk Van Raemdonck, Michael A Smith, Gilbert Massard, Jasleen Kukreja, Federico Rea, Gabriel Loor, Fabio De Robertis, Jayan Nagendran, Kumud K Dhital, Francisco Javier Moradiellos Díez, Christoph Knosalla, Christian A Bermudez, Steven Tsui, Kenneth McCurry, I-Wen Wang, Tobias Deuse, Guy Lesèche, Pascal Thomas, Igor Tudorache, Christian Kühn, Murat Avsar, Bettina Wiegmann, Wiebke Sommer, Arne Neyrinck, Marco Schiavon, Fiorella Calebrese, Nichola Santelmo, Anne Olland, Pierre-Emanuel Falcoz, Andre R Simon, Andres Varela, Joren C Madsen, Marshall Hertz, Axel Haverich, Abbas Ardehali
BACKGROUND: Severe primary graft dysfunction (PGD) of grade 3 (PGD3) is a common serious complication following lung transplantation. We aimed to assess physiological donor lung preservation using the Organ Care System (OCS) Lung device compared with cold static storage. METHODS: In this non-inferiority, randomised, controlled, open-label, phase 3 trial (INSPIRE) recipients were aged 18 years or older and were registered as standard criteria primary double lung transplant candidates...
April 9, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29643231/personalized-cancer-vaccine-effectively-mobilizes-antitumor-t-cell-immunity-in-ovarian-cancer
#20
Janos L Tanyi, Sara Bobisse, Eran Ophir, Sandra Tuyaerts, Annalisa Roberti, Raphael Genolet, Petra Baumgartner, Brian J Stevenson, Christian Iseli, Denarda Dangaj, Brian Czerniecki, Aikaterini Semilietof, Julien Racle, Alexandra Michel, Ioannis Xenarios, Cheryl Chiang, Dimitri S Monos, Drew A Torigian, Harvey L Nisenbaum, Olivier Michielin, Carl H June, Bruce L Levine, Daniel J Powell, David Gfeller, Rosemarie Mick, Urania Dafni, Vincent Zoete, Alexandre Harari, George Coukos, Lana E Kandalaft
We conducted a pilot clinical trial testing a personalized vaccine generated by autologous dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC), which was injected intranodally in platinum-treated, immunotherapy-naïve, recurrent ovarian cancer patients. OCDC was administered alone (cohort 1, n = 5), in combination with bevacizumab (cohort 2, n = 10), or bevacizumab plus low-dose intravenous cyclophosphamide (cohort 3, n = 10) until disease progression or vaccine exhaustion. A total of 392 vaccine doses were administered without serious adverse events...
April 11, 2018: Science Translational Medicine
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