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https://www.readbyqxmd.com/read/28815565/generation-of-animal-form-by-the-chordin-tolloid-bmp-gradient-100%C3%A2-years-after-d-arcy-thompson
#1
Edward M De Robertis, Yuki Moriyama, Gabriele Colozza
The classic book "On Growth and Form" by naturalist D'Arcy Thompson was published 100 years ago. To celebrate this landmark, we present experiments in the Xenopus embryo that provide a framework for understanding how simple, quantitative transformations of a morphogen gradient might have affected evolution and morphological diversity of organisms. D'Arcy Thompson proposed that different morphologies might be generated by modifying physical parameters in an underlying system of Cartesian coordinates that pre-existed in Nature and arose during evolutionary history...
August 16, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28779965/assessing-the-risk-of-pelvic-and-para-aortic-nodal-involvement-in-apparent-early-stage-ovarian-cancer-a-predictors-and-nomogram-based-analyses
#2
Giorgio Bogani, Elena Tagliabue, Antonino Ditto, Mauro Signorelli, Fabio Martinelli, Jvan Casarin, Valentina Chiappa, Giulia Dondi, Umberto Leone Roberti Maggiore, Cono Scaffa, Chiara Borghi, Luca Montanelli, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To estimate the prevalence of lymph node involvement in early-stage epithelial ovarian cancer in order to assess the prognostic value of lymph node dissection. METHODS: Data of consecutive patients undergoing staging for early-stage epithelial ovarian cancer were retrospectively evaluated. Logistic regression and a nomogram-based analysis were used to assess the risk of lymph node involvement. RESULTS: Overall, 290 patients were included...
August 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28716306/tertiary-cytoreductive-surgery-in-recurrent-epithelial-ovarian-cancer-a-multicentre-mito-retrospective-study
#3
F Falcone, G Scambia, P Benedetti Panici, M Signorelli, G Cormio, G Giorda, S Bogliolo, M Marinaccio, F Ghezzi, E Rabaiotti, E Breda, G Casella, F Fanfani, V Di Donato, U Leone Roberti Maggiore, S Greggi
OBJECTIVES: To evaluate the impact of tertiary cytoreductive surgery (TCS) on survival in recurrent epithelial ovarian cancer (EOC), and to determine predictors of complete cytoreduction. METHODS: A multi-institutional retrospective study was conducted within the MITO Group on a 5-year observation period. RESULTS: A total of 103 EOC patients with a ≥6month treatment-free interval (TFI) undergoing TCS were included. Complete cytoreduction was achieved in 71 patients (68...
July 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28678537/pharmacokinetic-drug-evaluation-of-pazopanib-for-the-treatment-of-uterine-leiomyosarcomas
#4
REVIEW
Simone Ferrero, Umberto Leone Roberti Maggiore, Nicoletta Aiello, Fabio Barra, Antonino Ditto, Giorgio Bogani, Francesco Raspagliesi, Domenica Lorusso
Uterine leiomyosarcomas (ULMS) represent 1.3% of all uterine malignant tumors. Surgery is the curative treatment for patients with early stage disease. In case of advanced, persistent or recurrent tumor, chemotherapy represents the standard of care, but these patients have a poor prognosis. As the results with available therapies are far from being satisfactory, research is focusing on identification of new compounds. In 2012 the Food and Drug Administration (FDA) licensed pazopanib for the treatment of advanced soft-tissue sarcomas failing previous chemotherapy...
August 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28677005/tumor-thrombosis-a-peculiar-finding-associated-with-pancreatic-neuroendocrine-neoplasms-a-pictorial-essay
#5
REVIEW
Riccardo De Robertis, Salvatore Paiella, Nicolò Cardobi, Luca Landoni, Paolo Tinazzi Martini, Silvia Ortolani, Giulia De Marchi, Stefano Gobbo, Alessandro Giardino, Giovanni Butturini, Giampaolo Tortora, Claudio Bassi, Mirko D'Onofrio
While abutment, encasement or vessel occlusion are identified in most patients with a pancreatic tumor, tumor thrombosis is an uncommon finding. In particular, there are no description in the literature of tumor thrombosis associated with ductal adenocarcinoma, the most common pancreatic tumor. On the other hand, surgical series reveal that tumor thrombosis is associated with about 5% of pancreatic neuroendocrine neoplasms (PanNENs), and literature data suggest that this finding is frequently underreported on pre-operative imaging examinations...
July 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28676014/citicoline-and-retinal-ganglion-cells-effects-on-morphology-and-function
#6
Vincenzo Parisi, Francesco Oddone, Lucia Ziccardi, Gloria Roberti, Gianluca Coppola, Gianluca Manni
Retinal ganglion cells (RGCs) are the nervous retinal elements that connect the visual receptors to the brain forming the nervous visual system. Functional and/or morphological involvement of RGCs occurs in several ocular and neurological disorders and therefore these cells are targeted in neuroprotective strategies. Cytidine 5-diphosphocholine or Citicoline is an endogenous compound that acts in the biosynthesis of phospholipids of cell membranes and increases neurotransmitters' levels in the Central Nervous System...
July 3, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28648635/pro-oxidant-pro-inflammatory-alterations-in-the-offspring%C3%A2-s-heart-of-mild-diabetic-rats-are-regulated-by-maternal-treatments-with-a-mitochondrial-antioxidant
#7
Romina Higa, Sabrina L Roberti, Evangelina Capobianco, Daiana Fornes, Verónica White, Alicia Jawerbaum
Maternal diabetes programs metabolic and cardiovascular diseases in the offspring. Here, we demonstrated increased pro-oxidant/pro-inflammatory markers in the heart of 2-day-old offspring of diabetic rats, previous to the induction of metabolic alterations. At a pre-pubertal stage, sex-dependent changes were evidenced in the diabetic group, as only males showed increased glycemia as well as increased concentrations of nitrated proteins, matrix metalloproteinase-9 and peroxisome proliferator activated receptor α (PPARα) in the heart...
June 23, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28612716/-molecular-oncogenesis-of-lymphomas-role-of-the-setd2-gene-in-intestinal-t-cell-lymphomas
#8
David Vallois, Annalisa Roberti, Bettina Bisig, Philippe Gaulard, Laurence de Leval
No abstract text is available yet for this article.
May 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28609854/a-revision-of-the-ewartia-oldfieldi-distant-species-complex-hemiptera-cicadidae-cicadettinae-with-five-new-species-from-eastern-and-northern-australia
#9
Lindsay W Popple
The identity of Ewartia oldfieldi (Distant) is re-examined and this species is redescribed. Five new species belonging to the genus Ewartia Moulds are described. Ewartia oldfieldi s. str. occurs in association with wattles (Acacia spp.; Mimosaceae) with large or fleshy phyllodes growing in soils derived from sandstone and coarse-grained metasediments throughout the south-eastern third of Queensland. Ewartia roberti n. sp. is associated with wattles that possess narrow or delicate phyllodes, growing in loam soils in southern Queensland and northern New South Wales...
May 10, 2017: Zootaxa
https://www.readbyqxmd.com/read/28591287/large-colloid-drusen-analyzed-with-structural-en-face-optical-coherence-tomography
#10
Nathália Corbelli Roberti, João Rafael de Oliveira Dias, Eduardo Amorim Novais, Caio Saito Regatieri, Rubens Belfort
Drusen are extracellular deposits between the basal lamina of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch's membrane. Large colloid drusen (LCD) are located below the RPE and are characterized by multiple, large, dome-shaped RPE detachments, with marked attenuation of the ellipsoid zone overlaying the drusen. This report presents the structural en face optical coherence tomography (OCT) findings of LCD and relates them to findings from fluorescein and indocyanine green angiography...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28586782/are-cystic-pancreatic-neuroendocrine-tumors-an-indolent-entity-results-from-a-single-center-surgical-series
#11
Salvatore Paiella, Giovanni Marchegiani, Marco Miotto, Anna Malpaga, Harmony Impellizzeri, Greta Montagnini, Tommaso Pollini, Chiara Nessi, Giovanni Butturini, Paola Capelli, Ilaria Posenato, Aldo Scarpa, Mirko D'Onofrio, Riccardo De Robertis, Sara Cingarlini, Letizia Boninsegna, Claudio Bassi, Roberto Salvia, Luca Landoni
No abstract text is available yet for this article.
June 7, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28564643/prevent-pancreatic-fistula-after-pancreatoduodenectomy-possible-role-of-ultrasound-elastography
#12
Mirko D'Onofrio, Giulia Tremolada, Riccardo De Robertis, Stefano Crosara, Valentina Ciaravino, Nicolò Cardobi, Giovanni Marchegiani, Alessandra Pulvirenti, Valentina Allegrini, Roberto Salvia, Claudio Bassi, Roberto Pozzi Mucelli
BACKGROUND: The purpose of the study is to evaluate the utility of acoustic radiation force impulse (ARFI) on pancreatic tissue as a preoperative predictor of postoperative pancreatic fistula (POPF). Studied patients underwent exclusively to pancreaticoduodenectomy (PD) surgery. METHODS: Shear wave velocity of pancreas was measured using ARFI in 71 patients scheduled for PD. An intraoperative pancreas palpation was made by surgeons. A postoperative clinical evaluation to detect occurrence of POPF was performed...
June 1, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28533666/comparison-of-imaging-based-and-pathological-dimensions-in-pancreatic-neuroendocrine-tumors
#13
Salvatore Paiella, Harmony Impellizzeri, Elisabetta Zanolin, Giovanni Marchegiani, Marco Miotto, Anna Malpaga, Riccardo De Robertis, Mirko D'Onofrio, Borislav Rusev, Paola Capelli, Sara Cingarlini, Giovanni Butturini, Maria Vittoria Davì, Antonio Amodio, Claudio Bassi, Aldo Scarpa, Roberto Salvia, Luca Landoni
AIM: To establish the ability of magnetic resonance (MR) and computer tomography (CT) to predict pathologic dimensions of pancreatic neuroendocrine tumors (PanNET) in a caseload of a tertiary referral center. METHODS: Patients submitted to surgery for PanNET at the Surgical Unit of the Pancreas Institute with at least 1 preoperative imaging examination (MR or CT scan) from January 2005 to December 2015 were included and data retrospectively collected. Exclusion criteria were: multifocal lesions, genetic syndromes, microadenomas or mixed tumors, metastatic disease and neoadjuvant therapy...
May 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28529325/anticancer-effects-of-the-microbiome-and-its-products
#14
REVIEW
Laurence Zitvogel, Romain Daillère, María Paula Roberti, Bertrand Routy, Guido Kroemer
The human gut microbiome modulates many host processes, including metabolism, inflammation, and immune and cellular responses. It is becoming increasingly apparent that the microbiome can also influence the development of cancer. In preclinical models, the host response to cancer treatment has been improved by modulating the gut microbiome; this is known to have an altered composition in many diseases, including cancer. In addition, cancer treatment with microbial agents or their products has the potential to shrink tumours...
August 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28505706/the-three-vessel-and-trachea-view-3vtv-in-the-first-trimester-of-pregnancy-an-additional-tool-in-screening-for-congenital-heart-defects-chd-in-an-unselected-population
#15
Valentina De Robertis, Georgios Rembouskos, Tiziana Fanelli, Grazia Volpe, Brunella Muto, Paolo Volpe
OBJECTIVE: The aim of the study was to evaluate the feasibility of obtaining the three-vessel and trachea view (3VTV) in an unselected population undergoing first trimester screening for aneuploidy, and to investigate its role in the early detection of congenital heart defects (CHD). METHODS: Cardiac examination was performed by expert sonographers. Abnormal findings of 3VTV were classified in three different subgroups: number, size and spatial relationship of the vessels...
July 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28501492/ldh-inhibition-impacts-on-heat-shock-response-and-induces-senescence-of-hepatocellular-carcinoma-cells
#16
Marcella Manerba, Lorenza Di Ianni, Marzia Govoni, Marinella Roberti, Maurizio Recanatini, Giuseppina Di Stefano
In normal cells, heat shock response (HSR) is rapidly induced in response to a variety of harmful conditions and represents one of the most efficient defense mechanism. In cancer tissues, constitutive activation converts HSR into a life-threatening process, which plays a major role in helping cell survival and proliferation. Overexpression of heat shock proteins (HSPs) has been widely reported in human cancers and was found to correlate with tumor progression. Hepatocellular carcinoma is one of the conditions in which HSR activation was shown to have the highest clinical significance...
May 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28499814/selected-cholesterol-biosynthesis-inhibitors-produce-accumulation-of-the-intermediate-ff-mas-that-targets-nucleus-and-activates-lxr%C3%AE-in-hepg2-cells
#17
Leonardo Gatticchi, Bruno Cerra, Paolo Scarpelli, Lara Macchioni, Bartolomeo Sebastiani, Antimo Gioiello, Rita Roberti
Sterol intermediates of the cholesterol biosynthetic pathway have drawn attention for novel biological activities. Follicular fluid meiosis activating sterol (FF-MAS) is a LXRα ligand and a potential modulator of physiologic processes regulated by nuclear receptors, such as lipid homeostasis and cell proliferation. In this work, we established a model to selectively accumulate FF-MAS in HepG2 cells, by using a combination of the inhibitors AY9944 and 17-hydroxyprogesterone to block C14-sterol reductases and the downstream C4-demethylase complex...
May 9, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28482343/fetal-tricuspid-regurgitation-in-the-first-trimester-as-a-screening-marker-for-congenital-heart-defects-systematic-review-and-meta-analysis
#18
Carolina Scala, Maddalena Morlando, Alessandra Familiari, Umberto Leone Roberti Maggiore, Simone Ferrero, Francesco D'Antonio, Asma Khalil
BACKGROUND: Assessment of tricuspid flow has been reported to improve the performance of screening for aneuploidies and congenital heart defects (CHD). However, the performance of tricuspid regurgitation (TR) as a screening marker for CHD in euploid fetuses is yet to be established. The main aim of this meta-analysis was to establish the predictive accuracy of TR for CHD. METHODS: MEDLINE, Embase, and the Cochrane Library were searched electronically utilizing combinations of the relevant medical subject heading for "fetus," "tricuspid regurgitation," and "first trimester...
2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28475092/technological-advances-in-endodontics-treatment-of-a-mandibular-molar-with-internal-root-resorption-using-a-reciprocating-single-file-system
#19
Samir Noronha de Souza, André Augusto Franco Marques, EmÍlio Carlos Sponchiado-Júnior, Lucas da Fonseca Roberti Garcia, Matheus Franco da Frota, Fredson Márcio Acris de Carvalho
The field of endodontics has become increasingly successful due to technological advances that allow clinicians to solve clinical cases that would have been problematic a few years ago. Despite such advances, endodontic treatment of teeth with internal root resorption remains challenging. This article presents a clinical case in which a reciprocating single-file system was used for endodontic treatment of a mandibular molar with internal root resorption. Radiographic examination revealed the presence of internal root resorption in the distobuccal root canal of the mandibular right first molar...
May 2017: General Dentistry
https://www.readbyqxmd.com/read/28473928/dka-induced-takotsubo-cardiomyopathy-in-patient-with-known-hocm
#20
Ayla Gordon, Gina LaCapra, Roberto Roberti
The first published case of Diabetic Ketoacidosis-induced Takotsubo cardiomyopathy was in 2009. Our patient is the 1st reported case of Diabetic Ketoacidosis- (DKA-) induced Takotsubo cardiomyopathy (TC) in a patient with known hypertrophic cardiomyopathy (HOCM) in the United States. In the literature, there are only two examples linking DKA to TC; however, this report focuses on the biochemical and physiological causes of TC in a patient with known HOCM and new-onset DKA. TC in previously diagnosed HOCM poses particular complications...
2017: Case Reports in Critical Care
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