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https://www.readbyqxmd.com/read/29679770/easy-to-read-informed-consent-form-for-hematopoietic-cell-transplantation-clinical-trials-results-from-bmt-ctn-1205-study
#1
Ryan Spellecy, Sergey Tarima, Ellen Denzen, Heather Moore, Sunil Abhyankar, Peter Dawson, Amy Foley, Iris Gersten, Mitchell Horwitz, Lensa Idossa, Steven Joffe, Naynesh Kamani, Roberta King, Aleksandr Lazaryan, Lawrence Morris, Mary M Horowitz, Navneet S Majhail
PURPOSE: Due to the complexity of hematopoietic cell transplant trial treatments, informed consent forms are often long and difficult to read. We evaluated a two-column easy-to-read informed consent (ETRIC) form that incorporates elements of health literacy and readability in participants and centers participating in Blood and Marrow Transplant Clinical Trials Network (BMT CTN) clinical trials. METHODS: In a randomized study, 198 adult patients from 25 centers potentially eligible to participate in four BMT CTN interventional trials were randomized to ETRIC or standard consent form for that trial...
April 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29679373/cytokine-producing-b-cells-promote-immune-mediated-bile-duct-injury-in-murine-biliary-atresia
#2
Joseph Bednarek, Brianna Traxinger, Dania Brigham, Jonathan Roach, David Orlicky, Dong Wang, Roberta Pelanda, Cara L Mack
Biliary atresia (BA) is a neonatal T cell-mediated inflammatory, sclerosing cholangiopathy. In the Rhesus rotavirus (RRV)-induced neonatal mouse model of BA (murine BA), mice lacking B cells do not develop BA, and the lack of B cells is associated with loss of T cell and macrophage activation. The aim of this study was to determine the mechanism of B cell-mediated immune activation (antigen presentation versus cytokine production) in murine BA. RESULTS: Normal neonatal B cells in the liver are predominantly at pro-B and pre-B cellular development...
April 20, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29679222/warranty-period-of-normal-stress-myocardial-perfusion-imaging-in-hypertensive-patients-a-parametric-survival-analysis
#3
Wanda Acampa, Francesco Rozza, Emilia Zampella, Roberta Assante, Teresa Mannarino, Carmela Nappi, Ciro Mainolfi, Mario Petretta, Bruno Trimarco, Alberto Cuocolo
BACKGROUND: We evaluated the warranty period of a normal stress myocardial perfusion single-photon emission computed tomography (MPS) in hypertensive patients. METHODS AND RESULTS: A total of 471 consecutive hypertensive patients with suspected coronary artery disease and normal perfusion at stress MPS were followed for a mean of 76 ± 21 months. Endpoint events were cardiac death or nonfatal myocardial infarction. With Cox analysis, age (hazard ratio 1.1, P < ...
April 20, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29679150/ten-year-comparative-analysis-of-incidence-prognosis-and-associated-factors-for-dialysis-and-renal-transplantation-in-type-1-and-type-2-diabetes-versus-non-diabetes
#4
Carlo Bruno Giorda, Paolo Carnà, Mario Salomone, Roberta Picariello, Giuseppe Costa, Barbara Tartaglino, Roberto Gnavi
AIMS: To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM). METHODS: Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative database (Piedmont, Italy), and the crude (cumulative) incidence of dialysis was calculated. Overall cumulative survival was estimated using the Kaplan-Meier method and compared using the log-rank test...
April 20, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29678865/economic-evaluation-of-quality-improvement-interventions-designed-to-improve-glycemic-control-in-diabetes-a-systematic-review-and-weighted-regression-analysis
#5
REVIEW
Teryl K Nuckols, Emmett Keeler, Laura J Anderson, Jonas Green, Sally C Morton, Brian J Doyle, Kanaka Shetty, Aziza Arifkhanova, Marika Booth, Roberta Shanman, Paul Shekelle
OBJECTIVE: Quality improvement (QI) interventions can improve glycemic control, but little is known about their value. We systematically reviewed economic evaluations of QI interventions for glycemic control among adults with type 1 or type 2 diabetes. RESEARCH DESIGN AND METHODS: We used English-language studies from high-income countries that evaluated organizational changes and reported program and utilization-related costs, chosen from PubMed, EconLit, Centre for Reviews and Dissemination, New York Academy of Medicine's Grey Literature Report, and WorldCat (January 2004 to August 2016)...
May 2018: Diabetes Care
https://www.readbyqxmd.com/read/29678768/safety-assessment-of-ethanolic-extract-of-olea-europaea-l-leaves-after-acute-and-subacute-administration-to-wistar-rats
#6
Camille Gaube Guex, Fernanda Ziegler Reginato, Kássia Caroline Figueredo, Andreia Regina Haas da Silva, Fernanda Brum Pires, Roberta da Silva Jesus, Cibele Lima Lhamas, Gilberti Helena Hübscher Lopes, Liliane de Freitas Bauermann
Olea europaea L., popularly known as olive, is a plant widely used worldwide. Its leaves, fruit and oil are extensively consumed and present important pharmacological properties. However, studies regarding the toxicity of olive leaves are still limited in the literature. Therefore, the aim of the study was to investigate acute and subacute oral toxicities of the ethanolic extract of olive leaves (EEO) in Wistar rats through histopathology and biochemical and hematological parameters. Acute toxicity was assessed using a single dose of 2000 mg/kg of EEO administered by oral gavage to male and female rats...
April 17, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29678640/changes-of-glucose-levels-precede-dementia-in-african-americans-with-diabetes-but-not-in-caucasians
#7
Hugh C Hendrie, Mengjie Zheng, Kathleen A Lane, Roberta Ambuehl, Christianna Purnell, Shanshan Li, Frederick W Unverzagt, Michael D Murray, Ashok Balasubramanyam, Chris M Callahan, Sujuan Gao
INTRODUCTION: Changes in glucose levels may represent a powerful metabolic indicator of dementia in African-Americans with diabetes. It is unclear whether these changes also occur in Caucasians. METHODS: A secondary data analysis using electronic medical records from 5228 African-Americans and Caucasians aged ≥65 years was carried out. Mixed effects models with repeated serum glucose measurements were used to compare changes in glucose levels between African-Americans and Caucasian patients with and without incident dementia...
April 17, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29678535/design-synthesis-molecular-modelling-and-in-vitro-cytotoxicity-analysis-of-novel-carbamate-derivatives-as-inhibitors-of-monoacylglycerol-lipase
#8
Simone Lauria, Cristiana Perrotta, Silvana Casati, Ilaria Di Renzo, Roberta Ottria, Ivano Eberini, Luca Palazzolo, Chiara Parravicini, Pierangela Ciuffreda
Monoacylglycerol lipase (MAGL) has an essential role in the catabolic pathway of the endocannabinoid 2-arachidonoylglycerol, which makes it a potential target for highly specific inhibitors for the treatment of a number of diseases. We designed and synthesized a series of carbamate analogues of URB602. We evaluated their inhibitory activity toward human MAGL in vitro both in cell culture and lysates. The target compounds exhibited moderate to excellent inhibitory activity against MAGL. The most promising compound 2b showed good inhibitory activity with IC50 value of 4...
April 12, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29678187/an-unexpected-cause-of-sacroiliitis-in-a-patient-with-gout-and-chronic-psoriasis-with-inflammatory-arthritis-a-case-report
#9
Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan, Grainne Murphy
BACKGROUND: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. In this case, it is difficult to specifically identify gout as a cause by ordinary imaging like magnetic resonance imaging (MRI) or ultrasound...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29677698/air-water-and-soil-which-alternatives-alternative-models-in-environmental-toxicology
#10
Yula Sambuy, Susanna Alloisio, Giorgio Bertanza, Donatella Ferretti, Silvia Letasiova, Giovanna Mazzoleni, Roberta Pedrazzani, Francesca Caloni
No abstract text is available yet for this article.
2018: ALTEX
https://www.readbyqxmd.com/read/29677319/focusing-and-orienting-spatial-attention-differently-modulate-crowding-in-central-and-peripheral-vision
#11
Andrea Albonico, Marialuisa Martelli, Emanuela Bricolo, Eleonora Frasson, Roberta Daini
The allocation of attentional resources to a particular location or object in space involves two distinct processes: an orienting process and a focusing process. Indeed, it has been demonstrated that performance of different visual tasks can be improved when a cue, such as a dot, anticipates the position of the target (orienting), or when its dimensions (as in the case of a small square) inform about the size of the attentional window (focusing). Here, we examine the role of these two components of visuo-spatial attention (orienting and focusing) in modulating crowding in peripheral (Experiment 1 and Experiment 3a) and foveal (Experiment 2 and Experiment 3b) vision...
March 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29675627/rectal-cancer-mri-protocols-signs-and-future-perspectives-radiologists-should-consider-in-everyday-clinical-practice
#12
REVIEW
Andrea Delli Pizzi, Raffaella Basilico, Roberta Cianci, Barbara Seccia, Mauro Timpani, Alessandra Tavoletta, Daniele Caposiena, Barbara Faricelli, Daniela Gabrielli, Massimo Caulo
Magnetic resonance imaging (MRI) allows to non-invasively evaluate rectal cancer staging and to assess the presence of "prognostic signs" such as the distance from the anorectal junction, the mesorectal fascia infiltration and the extramural vascular invasion. Moreover, MRI plays a crucial role in the assessment of treatment response after chemo-radiation therapy, especially considering the growing interest in the new conservative policy (wait and see, minimally invasive surgery). We present a practical overview regarding the state of the art of the MRI protocol, the main signs that radiologists should consider for their reports during their clinical activity and future perspectives...
April 19, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29674199/the-impact-of-female-fetal-sex-on-preeclampsia-and-the-maternal-immune-milieu
#13
Brandie D Taylor, Roberta B Ness, Mark A Klebanoff, Gong Tang, James M Roberts, David M Hougaard, Kristin Skogstrand, Catherine L Haggerty
OBJECTIVE: Small studies suggest that fetal sex alters maternal inflammation. We examined the association between fetal sex, preeclampsia and circulating maternal immune markers. METHODS: This was a secondary data analysis within a nested case-control study of 216 preeclamptic women and 432 randomly selected normotensive controls from the Collaborative Perinatal Project. All women had singleton, primiparous pregnancies without chronic health conditions. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between female fetal sex and preeclampsia...
February 24, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673795/electrochemotherapy-for-breast-cancer-results-from-the-inspect-database
#14
Louise Wichmann Matthiessen, Mohammed Keshtgar, Pietro Curatolo, Christian Kunte, Eva-Maria Grischke, Joy Odili, Tobian Muir, David Mowatt, James P Clover, Se Hwang Liew, Karin Dahlstroem, Jackie Newby, Valerie Letulé, Eva Stauss, Alison Humphreys, Shramana Banerjee, Annette Klein, Roberta Rotunno, Francesca de Terlizzi, Julie Gehl
BACKGROUND: Cutaneous recurrence from breast cancer can pose a clinical challenge. It might be the only disease site, or could be part of disseminated disease, and often profoundly affects quality of life. Electrochemotherapy is a palliative treatment using electric pulses to locally permeabilize tumor cells and thereby significantly increase bleomycin cytotoxicity. Collaborating with the International Network for Sharing Practice on ElectroChemoTherapy (INSPECT), we consecutively and prospectively accrued data on patients treated with electrochemotherapy for cutaneous metastases from breast cancer...
March 14, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29673166/revisiting-strephosymbolie-the-connection-between-interhemispheric-transfer-and-developmental-dyslexia
#15
Roberta Daini, Paola De Fabritiis, Chiara Ginocchio, Carlo Lenti, Cristina Michela Lentini, Donatella Marzorati, Maria Luisa Lorusso
The hypothesis that an atypical hemispheric specialization is associated to developmental dyslexia (DD) is receiving renewed interest, lending some support to Orton&rsquo;s theory. In this article, we investigated whether interhemispheric transfer processes (IHT) are likely to be involved in developmental dyslexia. In this study, we tested 13 children with developmental dyslexia and 13 matched controls (aged 8 to 13 years) in four different tasks. In a tactile transfer task, the dyslexic children&rsquo;s performance was less accurate...
April 17, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29673020/cucurbit-7-uril-dimethyllysine-recognition-in-a-model-protein
#16
Francesca Guagnini, Pawel Antonik, Martin Rennie, Peter O'Byrne, Amir Khan, Roberta Pinalli, Enrico Dalcanale, Peter B Crowley
Here, we provide the first structural characterization of host-guest complexation between cucurbit[7]uril (Q7) and dimethyl-lysine (KMe2) in a model protein. Binding was dominated by complete encapsulation of the dimethylammonium functional group. While selectivity for the most sterically accessible dimethyllysine was observed both in solution and in the solid state, three different modes of Q7-KMe2 complexation were revealed by X-ray crystallography. The crystal structures revealed also entrapped water molecules that persisted in solvating the ammonium group within the Q7 cavity...
April 19, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29670593/technologies-and-trends-to-improve-table-olive-quality-and-safety
#17
REVIEW
Marco Campus, Nurcan Değirmencioğlu, Roberta Comunian
Table olives are the most widely consumed fermented food in the Mediterranean countries. Peculiar processing technologies are used to process olives, which are aimed at the debittering of the fruits and improvement of their sensory characteristics, ensuring safety of consumption at the same time. Processors demand for novel techniques to improve industrial performances, while consumers' attention for natural and healthy foods has increased in recent years. From field to table, new techniques have been developed to decrease microbial load of potential spoilage microorganisms, improve fermentation kinetics and ensure safety of consumption of the packed products...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29670571/electromyographical-gait-characteristics-in-parkinson-s-disease-effects-of-combined-physical-therapy-and-rhythmic-auditory-stimulation
#18
Christopher A Bailey, Federica Corona, Mauro Murgia, Roberta Pili, Massimiliano Pau, Julie N Côté
Background: In persons with Parkinson's disease (PD), gait dysfunctions are often associated with abnormal neuromuscular function. Physical therapy combined with auditory stimulation has been recently shown to improve motor function and gait kinematic patterns; however, the underlying neuromuscular control patterns leading to this improvement have never been identified. Objectives: (1) Assess the relationships between motor dysfunction and lower limb muscle activity during gait in persons with PD; (2) Quantify the effects of physical therapy with rhythmic auditory stimulation (PT-RAS) on lower limb muscle activity during gait in persons with PD...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29670177/proton-decoupled-carbon-magnetic-resonance-spectroscopy-in-human-calf-muscles-at-7-t-using-a-multi-channel-radiofrequency-coil
#19
Sigrun Goluch, Roberta Frass-Kriegl, Martin Meyerspeer, Michael Pichler, Jürgen Sieg, Martin Gajdošík, Martin Krššák, Elmar Laistler
13 C magnetic resonance spectroscopy is a viable, non-invasive method to study cell metabolism in skeletal muscles. However, MR sensitivity of 13 C is inherently low, which can be overcome by applying a higher static magnetic field strength together with radiofrequency coil arrays instead of single loop coils or large volume coils, and 1 H decoupling, which leads to a simplified spectral pattern. 1 H-decoupled 13 C-MRS requires RF coils which support both, 1 H and 13 C, Larmor frequencies with sufficient electromagnetic isolation between the pathways of the two frequencies...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29668978/atazanavir-ritonavir-with-lamivudine-as-maintenance-therapy-in-virologically-suppressed-hiv-infected-patients-96-week-outcomes-of-a-randomized-trial
#20
Massimiliano Fabbiani, Roberta Gagliardini, Nicoletta Ciccarelli, Eugenia Quiros Roldan, Alessandra Latini, Gabriella d'Ettorre, Andrea Antinori, Antonella Castagna, Giancarlo Orofino, Daniela Francisci, Pierangelo Chinello, Giordano Madeddu, Pierfrancesco Grima, Stefano Rusconi, Barbara Del Pin, Francesca Lombardi, Alessandro D'Avino, Emanuele Focà, Manuela Colafigli, Roberto Cauda, Simona Di Giambenedetto, Andrea De Luca
Objectives: To investigate the long-term safety and efficacy of a treatment switch to dual ART with atazanavir/ritonavir + lamivudine versus continuing a standard regimen with atazanavir/ritonavir + 2NRTI in virologically suppressed patients. Methods: ATLAS-M is a 96 week open-label, randomized, non-inferiority (margin -12%) trial enrolling HIV-infected adults on atazanavir/ritonavir + 2NRTI, with stable HIV-RNA <50 copies/mL and CD4 counts >200 cells/mm3...
April 12, 2018: Journal of Antimicrobial Chemotherapy
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