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https://www.readbyqxmd.com/read/27923116/new-evidence-in-support-of-staging-approaches-in-schizophrenia-differences-in-clinical-profiles-between-first-episode-early-stage-and-late-stage
#1
Bruno Bertolucci Ortiz, Fernanda Dal Medico Eden, Aline Silva Rodrigues de Souza, Carla Agostinho Teciano, Daniela Malatesta de Lima, Cristiano Noto, Cinthia Hiroko Higuchi, Hugo Cogo-Moreira, Rodrigo Affonseca Bressan, Ary Gadelha
Few studies have examined the progression of symptom dimensions in schizophrenia patients over the course of the illness. The objective of this study was to investigate whether clinical and psychopathological differences exist between first-episode schizophrenia (FES) and multiple-episode patients in an inpatient setting. Patients (N=203) were evaluated using the Positive and Negative Syndrome Scale (PANSS) over time. Five different generalized estimating equations were built for the PANSS factors using the following as covariates: sex, patient's age, assessment time point (i...
November 18, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27922552/novel-use-of-all-trans-retinoic-acid-in-a-model-of-lipopolysaccharide-immunosuppression-to-decrease-the-generation-of-myeloid-derived-suppressor-cells-by-reducing-the-proliferation-of-cd34-precursor-cells
#2
Daiana Martire-Greco, Nahuel Rodriguez-Rodrigues, Luis A Castillo, María Belén Vecchione, Marcelo de Campos-Nebel, Marlina Córdoba Moreno, Roberto Meiss, Mónica Vermeulen, Veronica I Landoni, Gabriela C Fernandez
All-trans-Retinoic Acid (ATRA) is a derivative of vitamin A with anti-proliferative properties. Endotoxin shock and subsequent immunosuppression (IS) by lipopolysaccharide (LPS) stimulates myelopoiesis with expansion of myeloid-derived suppressor cells (MDSC). Since we have previously shown that ATRA reverses the IS state by decreasing functional MDSC, our aim was to investigate if ATRA was able to modulate MDSC generation by regulating myelopoiesis in murine hematopoietic organs. We found that ATRA administration in vivo and in vitro decreased the number of CD34+ precursor cells that were increased in IS mice...
November 25, 2016: Shock
https://www.readbyqxmd.com/read/27921359/modulation-of-vegf-signaling-in-a-mouse-model-of-diabetes-by-xanthohumol-and-8-prenylnaringenin-unveiling-the-angiogenic-paradox-and-metabolism-interplay
#3
Raquel Costa, Ilda Rodrigues, Luísa Guardão, Joana Quelhas Lima, Emília Sousa, Raquel Soares, Rita Negrão
SCOPE: Imbalance in kidney and heart neovascularization is common in type2 Diabetes (T2DM) patients. Nevertheless, the mechanisms governing this angiogenic paradox have not been elucidated. Xanthohumol (XN) and 8-prenylnaringenin (8PN) beer polyphenols modulate angiogenesis, being thus targets for T2DM-related complications. Our work examined whether polyphenols consumption affects angiogenic paradox and metabolism in a T2DM mouse model. METHODS AND RESULTS: An increase in kidney and a reduction in left ventricle (LV) microvessels of diabetic C57Bl/6 mice were observed...
December 6, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27921341/unexpected-effect-of-the-vehicle-grain-ethanol-of-homeopathic-fsh-on-the-in-vitro-survival-and-development-of-isolated-ovine-preantral-follicles
#4
Lartiza F Lima, Rebeca M P Rocha, Ana Beatriz G Duarte, Ivina R Brito, Gerlane M Silva, Giovanna Q Rodrigues, Diana C S Nunes-Pinheiro, Antônia D Sales, Arlindo A Moura, Matthew B Wheeler, Ana Paula R Rodrigues, Cláudio C Campello, José Ricardo Figueiredo
The aims of this study were to investigate the effects of medium replacement system (experiment I) and of FSH presentations (homeopathic - FSH 6cH and allopathic FSH - rFSH; experiment II) on the in vitro development, hormone production and gene expression of isolated ovine preantral follicles cultured for 6 days. In experiment I, secondary follicles were cultured in the α-MEM(+) supplemented with FSH 6cH (0.05 fg/ml) or recombinant bovine FSH (100 ng/ml) without/with daily medium addition. The homeopathic FSH treatments with/without medium addition improved (p < ...
December 5, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27920870/pyle-disease-metaphyseal-dysplasia-presenting-in-two-adult-sisters
#5
Diego Ximenes Soares, Amália Mapurunga Almeida, André Rodrigues Façanha Barreto, Ilze Jucá Alencar E Silva, José Daniel Vieira de Castro, Francisco José Magalhães Pinto, Daniel Aguiar Dias, Lindenberg Barbosa Aguiar
Pyle's disease is an extremely rare skeletal disorder characterized by a benign course and an autosomal recessive genetic pattern of inheritance. Its causal mutation is still unknown. In the medical literature, fewer than 30 cases have been described to date. We report the case of two female siblings, daughters of consanguineous parents, referred to the radiology department complaining of genu valgum. Laboratory tests showed no other relevant findings. Conventional radiography plain films revealed Erlenmeyer flask deformity in bilateral femorotibial metaphyses, metaphyseal flaring of long bones, and mild sclerosis of the skull base...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920084/caffeine-consumption-during-pregnancy-and-adhd-at-the-age-of-11%C3%A2-years-a-birth-cohort-study
#6
Bianca Del-Ponte, Iná S Santos, Luciana Tovo-Rodrigues, Luciana Anselmi, Tiago N Munhoz, Alicia Matijasevich
OBJECTIVE: Studies evaluating caffeine intake during pregnancy and long-term outcomes, such as the child's neurobehaviour, are still scarce and their results are inconsistent. The objective of the present study was to evaluate the association between maternal consumption of caffeine during pregnancy and attention deficit hyperactivity disorder (ADHD) at the age of 11 years. METHODOLOGY: All children born in the city of Pelotas, Brazil, during the year 2004, were selected for a cohort study...
December 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27919786/increasing-in-cysteine-proteinase-b-expression-and-enzymatic-activity-during-in-vitro-differentiation-of-leishmania-viannia-braziliensis-first-evidence-of-modulation-during-morphological-transition
#7
Cinthia Bernardes Gomes, Franklin Souza da Silva, Karen Dos Santos Charret, Bernardo Acácio Santini Pereira, Léa Cysne Finkelstein, Raquel Santos de Souza, Luzia Monteiro de Castro Côrtes, Mirian Claudia Souza Pereira, Francisco Odêncio Rodrigues de Oliveira, Carlos Roberto Alves
Leishmania (Viannia) braziliensis presents adaptive protease-dependent mechanisms, as cysteine proteinases B (CPB). This work focuses on the expression of three cpb gene isoforms and CPB enzymatic activity during the parasite differentiation. Relative expression levels of LbrM.08.0810 gene was assessed, showing a higher quantity of transcripts in the logarithmic promastigotes phase than in the stationary promastigotes phase (> 1.5 times). The cbp gene tends to decrease during acid pH shock and increases when the temperature rises (> 1...
December 2, 2016: Biochimie
https://www.readbyqxmd.com/read/27919270/delayed-hyperbaric-oxygen-therapy-for-air-emboli-after-open-heart-surgery-case-report-and-review-of-a-success-story
#8
Eva Niyibizi, Guillaume Elyes Kembi, Claude Lae, Rodrigue Pignel, Tornike Sologashvili
BACKGROUND: The current case describes a rare diagnosis of iatrogenic air emboli after elective cardiopulmonary bypass that was successfully treated with delayed hyperbaric oxygen therapy, with good clinical evolution in spite of rare complications. CASE PRESENTATION: A 35 years old male was admitted to the intensive care unit (ICU) for post-operative management after being placed on cardiopulmonary bypass (CPB) for an elective ventricular septal defect closure and aortic valvuloplasty...
December 5, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27918732/relationship-between-889-c-t-polymorphism-in-interleukin-1a-gene-and-risk-of-chronic-periodontitis-evidence-from-a-meta-analysis-with-new-published-findings
#9
F-R-P da Silva, A-C-C Guimarães-Vasconcelos, L-F de-Carvalho-França, D di-Lenardo, L-S Rodrigues, M-L-L Barreto-do-Nascimento, D-F-P Vasconcelos
BACKGROUND: Periodontitis results from an inflammatory response caused by accumulative microorganisms in periodontal sites. Several factors are involved in pathogenesis of periodontitis, for example the -889 C/T polymorphism in interleukin-1A gene. This study aimed to evaluate the relationship between this polymorphism and risk of development of chronic periodontitis by a meta-analysis based in new published findings. MATERIAL AND METHODS: Thereunto a review in literature was performed in the electronic biomedical and education databases (Cochrane Library, Google Scholar, MEDLINE and PubMed) to studies published before August 2, 2015, the abstracts were evaluated and the data extraction performed by two calibrated examiners...
December 6, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27918598/sighted-and-visually-impaired-students-perspectives-of-illustrations-diagrams-and-drawings-in-school-science
#10
Celia McDonald, Susan Rodrigues
Background In this paper we report on the views of students with and without visual impairments on the use of illustrations, diagrams and drawings (IDD) in science lessons. Method Our findings are based on data gathered through a brief questionnaire completed by a convenience sample of students prior to trialling new resource material. The questionnaire sought to understand the students' views about using IDD in science lessons. The classes involved in the study included one class from a primary school, five classes from a secondary school and one class from a school for visually impaired students...
2016: Wellcome Open Res
https://www.readbyqxmd.com/read/27916942/evidence-of-bioactive-compounds-from-vernonia-polyanthes-leaves-with-topical-anti-inflammatory-potential
#11
Kamilla C M Rodrigues, Lucas A Chibli, Bruna C S Santos, Vanessa S Temponi, Nícolas C C Pinto, Elita Scio, Glauciemar Del-Vechio-Vieira, Maria S Alves, Orlando V Sousa
Vernonia polyanthes Less. (Asteraceae), popularly known as "assa-peixe", is a plant species used in Brazilian traditional medicine for the treatment of cutaneous damage, cicatrization, inflammation, and rheumatism. Based on these ethnopharmacological findings, the current study evaluated the topical anti-inflammatory effects of the hexane (HEVP) and ethyl acetate (EAEVP) extracts from V. polyanthes leaves in experimental models of skin inflammation. Chemical characterization was carried out by HPLC-UV/DAD analysis...
December 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27916585/perinatal-exposure-to-glyphosate-based-herbicide-alters-the-thyrotrophic-axis-and-causes-thyroid-hormone-homeostasis-imbalance-in-male-rats
#12
Janaina Sena de Souza, Marina Malta Letro Kizys, Rodrigo Rodrigues da Conceição, Gabriel Glebocki, Renata Marino Romano, Tania Maria Ortiga-Carvalho, Gisele Giannocco, Ismael Dale Cotrim Guerreiro da Silva, Magnus Regios Dias da Silva, Marco Aurélio Romano, Maria Izabel Chiamolera
Glyphosate-based herbicides (GBHs) are widely used in agriculture. Recently, several animal and epidemiological studies have been conducted to understand the effects of these chemicals as an endocrine disruptor for the gonadal system. The aim of the present study was to determine whether GBHs could also disrupt the hypothalamic-pituitary-thyroid (HPT) axis. Female pregnant Wistar rats were exposed to a solution containing GBH Roundup(®)Transorb (Monsanto). The animals were divided into three groups (control, 5mg/kg/day or 50mg/kg/day) and exposed from gestation day 18 (GD18) to post-natal day 5 (PND5)...
December 1, 2016: Toxicology
https://www.readbyqxmd.com/read/27916273/identification-of-agnors-and-cytopathological-changes-in-oral-lichen-planus-lesions
#13
Stefânia Jeronimo Ferreira, Maria Ângela Naval Machado, Antônio Adilson Soares de Lima, Aline Cristina Batista Rodrigues Johann, Ana Maria Trindade Grégio, Luciana Reis Azevedo-Alanis
OBJECTIVE: To evaluate cytopathological changes in epithelial cells of the oral mucosa of patients with oral lichen planus (OLP) compared with patients without OLP. SUBJECTS AND METHODS: Swabs were collected from the oral mucosa of 20 patients with OLP (case group) and 20 patients without OLP (control group) using liquid-based cytology. After Papanicolaou staining, the smears were characterized based on Papanicolaou classification and degree of maturation. Nuclear area (NA) measurements, cytoplasmic area (CA) measurements, and the NA/CA ratio were determined from 50 epithelial cells per slide...
December 1, 2016: Acta Histochemica
https://www.readbyqxmd.com/read/27915452/chronic-enalapril-treatment-increases-transient-outward-potassium-current-in-cardiomyocytes-isolated-from-right-ventricle-of-spontaneously-hypertensive-rats
#14
Luiz Fernando Rodrigues Junior, Ana Carolina de Azevedo Carvalho, Enildo Broetto Pimentel, José Geraldo Mill, José Hamilton Matheus Nascimento
It has been well established that chronic pressure overload resulting from hypertension leads to ventricular hypertrophy and electrophysiological remodeling. The transient outward potassium current (I to) reduction described in hypertensive animals delays ventricular repolarization, leading to complex ventricular arrhythmias and sudden death. Antihypertensive drugs, as angiotensin-converting enzyme inhibitors (ACEi), can restore I to and reduce the incidence of arrhythmic events. The purpose of this study was to evaluate the differential effects of long-term treatment with ACEi or direct-acting smooth muscle relaxant on the I to of left and right ventricle myocytes of spontaneously hypertensive rats (SHR)...
December 3, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27914800/discovery-of-a-new-isomannide-based-peptidomimetic-synthetized-by-ugi-multicomponent-reaction-as-human-tissue-kallikrein-1-inhibitor
#15
Thalita G Barros, Jorge A N Santos, Bruno E G de Souza, Ana Carolina R Sodero, Alessandra M T de Souza, Dayane P da Silva, Carlos Rangel Rodrigues, Sergio Pinheiro, Luiza R S Dias, Bárbara Abrahim-Vieira, Luciano Puzer, Estela M F Muri
Human kallikrein 1 (KLK1) is the most extensively studied member of this family and plays a major role in inflammation processes. From Ugi multicomponent reactions, isomannide-based peptidomimetic 10 and 13 where synthesized and showed low micromolar values of IC50 for KLK1 The most active compound (10) presented competitive mechanism, with three structural modifications important to interact with active site residues which corroborates its KLK1 inhibition. Finally, the most active compound also showed good ADMET profile, which indicates compound 10 as a potential hit in the search for new KLK1 inhibitors with low side effects...
November 18, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27914594/association-of-pdcd1-polymorphism-to-systemic-lupus-erythematosus-and-rheumatoid-arthritis-susceptibility
#16
Luisa Matos do Canto, Ticiana Della Justina Farias, Mayara Delagnelo Medeiros, Cíntia Callegari Coêlho, Aline Fernanda Rodrigues Sereia, Lia Kubelka Fernandes de Carlos Back, Filipe Martins de Mello, Adriana Fontes Zimmermann, Ivânio Alves Pereira, Ilíada Rainha de Souza
OBJECTIVE: This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A - rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy-Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p≤0...
November 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27914363/new-insights-into-the-sar-and-drug-combination-synergy-of-2-quinolin-4-yloxy-acetamides-against-mycobacterium-tuberculosis
#17
Bruno Couto Giacobbo, Kenia Pissinate, Valnês Rodrigues-Junior, Anne Drumond Villela, Estêvão Silveira Grams, Bruno Lopes Abbadi, Fernanda Teixeira Subtil, Nathalia Sperotto, Rogério Valim Trindade, Davi Fernando Back, Maria Martha Campos, Luiz Augusto Basso, Pablo Machado, Diógenes Santiago Santos
2-(Quinolin-4-yloxy)acetamides have been described as potent and selective in vitro inhibitors of Mycobacterium tuberculosis (Mtb) growth. Herein, a new series of optimized compounds were found to demonstrate highly potent antitubercular activity, with minimum inhibitory concentration (MIC) values against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains in the submicromolar range. Furthermore, the most active compounds had no apparent toxicity to mammalian cells, and they showed intracellular activities similar to those of isoniazid and rifampin in a macrophage model of Mtb infection...
November 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27914160/infectious-postpartum-sacroiliitis-the-importance-and-difficulty-of-early-diagnosis
#18
Emídio Vale-Fernandes, Fedra Rodrigues, Carla Monteiro, Luís Carvalho
The sacroiliitis accounts for about 1.5% - 10% of all cases of septic arthritis and it is strongly associated with gynaecological infections, pelvic trauma or drug abuse (3.4% - 12.8% of cases occur during the postpartum period). Early diagnosis is difficult because the symptoms are nonspecific in pregnancy and in the postpartum period, making the delay of treatment a serious risk of irreversible damage to the joint and development of post-infectious complications. The authors describe the case of a 37-year-old puerperal woman presented to hospital, weeks after urgent caesarean section, with endometritis, post-anesthetic epidural hematoma and secondary infectious postpartum sacroiliitis...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27914154/short-and-long-term-efficacy-of-laparoscopic-ovarian-diathermy-in-women-with-polycystic-ovary-syndrome
#19
Rita Luz, Joana Barros, Ana Aguiar, Cátia Rodrigues, Ana Paula Soares, Joaquim Nunes, Sandra Sousa, Carlos Calhaz-Jorge
INTRODUCTION: Polycystic ovary syndrome is the most frequent cause of anovulatory infertility and management involves a multistep approach. Laparoscopic ovarian diathermy is accepted as a second-line treatment of patients who failed to respond to clomiphene citrate. The aims of this study were to determine the efficacy of this technique at short and long-term and to perform an analysis of predictive factors of spontaneous pregnancy. MATERIAL AND METHODS: This retrospective study involved 76 women who underwent laparoscopic ovarian diathermy between 2004 and 2013 in a university hospital...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27914151/-analysis-of-the-cochrane-review-portion-package-or-tableware-size-for-changing-selection-and-consumption-of-food-alcohol-and-tobacco-cochrane-database-syst-rev-2015-09-cd011045
#20
Gonçalo S Duarte, Filipe Brogueira Rodrigues, João Costa, António Vaz-Carneiro
Some of the main causes of mortality and morbidity among the developed countries - such as the cardiovascular, neurological and oncologic diseases - are deeply associated with modifiable risk factors. Primordial/primary prevention strategies that alter our environment can have an impact on these risk factors. The authors of this Cochrane systematic review sought evidence from randomized controlled trials to study the effect of the size of portions, packages, dishes and cups, as well as their respective formats, on the consumption and selection of food, alcoholic and non-alcoholic beverages and tobacco products...
August 2016: Acta Médica Portuguesa
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