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https://www.readbyqxmd.com/read/29353360/in-situ-monitoring-of-the-sinos-river-southern-brazil-water-quality-parameters-biomarkers-and-metal-bioaccumulation-in-fish
#1
Thaís Dalzochio, Gabriela Zimmermann Prado Rodrigues, Leonardo Airton Ressel Simões, Mateus Santos de Souza, Ismael Evandro Petry, Natália Bordin Andriguetti, Gláucia Joselaine Herbert Silva, Luciano Basso da Silva, Günther Gehlen
The Sinos River is an important water supply in Southern Brazil and receives industrial, agricultural, and domestic effluents which may affect aquatic biota. Water physicochemical and microbiological analyses, biomarker responses (scaled mass index (SMI), gill histopathology, and micronucleus and nuclear abnormality (MN and NA) frequencies), and metal bioaccumulation in muscle were assessed in the fish species Bryconamericus iheringii (Characidae) captured at three sampling sites (S1, S2, and S3) in four sampling periods...
January 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29353198/a-tiered-approach-to-assess-effects-of-diclofenac-on-the-brown-mussel-perna-perna-a-contribution-to-characterize-the-hazard
#2
Mayana Karoline Fontes, Paloma Kachel Gusso-Choueri, Luciane Alves Maranho, Denis Moledo de Souza Abessa, Wesley Almeida Mazur, Bruno Galvão de Campos, Luciana Lopes Guimarães, Marcos Sergio de Toledo, Daniel Lebre, Joyce Rodrigues Marques, Andreia Arantes Felicio, Augusto Cesar, Eduardo Alves Almeida, Camilo Dias Seabra Pereira
Pharmaceutical discharges into the aquatic ecosystem are of environmental concern and sewage treatment plants (STPs) have been pointed out as the major source of these compounds to coastal zones, where oceanic disposal of sewage occurs through submarine outfalls. Diclofenac (DCF) is one of the most frequently detected pharmaceuticals in water, but little is known about the effects on marine organisms. In this study, we employed a tiered approach involving the determination of environmental concentrations of DCF in marine water and the adverse biological effects for fertilization, embryo-larval development and biomarker responses of the mussel Perna perna...
December 29, 2017: Water Research
https://www.readbyqxmd.com/read/29353169/integrated-biomarkers-response-confirm-the-antioxidant-role-of-diphenyl-diselenide-against-atrazine
#3
Aline Teixeira Marins, Cíntia Côrte Real Rodrigues, Charlene Cavalheiro de Menezes, Jeane de Lima Costa Gomes, Maiara Dorneles Costa, Mauro Eugênio Medina Nunes, Mariela de Souza Vieira, Filipe Fagan Donato, Renato Zanella, Leila Picolli da Silva, Vania Lucia Loro
Atrazine (ATZ) is a herbicide worldwide used. That can cause oxidative damage in non-target organisms, such as fish. Furthermore, the threat of exposure to pesticides together with poor nutrition is hazardous to the normal development of fish, and supplementation of the fish diet with antioxidants compounds is an alternative approach to prevent the hazardous effects of pesticide exposure. Here we aimed to investigate the capacity of diphenyl diselenide (PhSe)2 diet supplementation to improve the antioxidant defense of Cyprinus carpio (carp) exposed to environmental concentrations of ATZ...
January 16, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29352746/the-common-bean-cok-4-and-the-arabidopsis-fer-kinase-domain-share-similar-function-in-plant-growth-and-defense
#4
Rafhael Felipin Azevedo, Maria Celeste Gonçalves Vidigal, Paula Rodrigues Oblessuc, Maeli Melotto
Receptor-like kinases are membrane proteins that can be shared by diverse signaling pathways. Among them, the Arabidopsis thaliana FERONIA (FER) plays a role in the balance between distinct signals to control growth and defense. We have found that COK-4, a putative kinase encoded in the common bean anthracnose resistance locus Co-4 that is transcriptionally regulated during immune response, is highly similar to the kinase domain of FER. To assess whether COK-4 is a functional ortholog of FER, we expressed COK-4 in the wild type Col-0 and the fer-5 mutant of Arabidopsis and evaluated FER-associated traits...
January 20, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29352482/influence-of-pharmacogenetic-polymorphisms-and-demographic-variables-on-metformin-pharmacokinetics-in-an-admixed-brazilian-cohort
#5
Ana Beatriz Santoro, Mariana Rodrigues Botton, Claudio José Struchiner, Guilherme Suarez-Kurtz
AIM: To identify pharmacogenetic and demographic variables that influence the systemic exposure to metformin in an admixed Brazilian cohort. METHODS: The extreme discordant phenotype was used to select 106 data sets from nine metformin bioequivalence trials, comprising 256 healthy adults. Eleven single-nucleotide polymorphisms in SLC22A1, SLC22A2, SLC47A1 SLC47A2 and in transcription factor SP1 were genotyped and a validated panel of ancestry informative markers was used to estimate the individual proportions of biogeographical ancestry...
January 20, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29352453/measuring-surgical-safety-during-minimally-invasive-surgical-procedures-a-validation-study
#6
Mathijs D Blikkendaal, Sara R C Driessen, Sharon P Rodrigues, Johann P T Rhemrev, Maddy J G H Smeets, Jenny Dankelman, John J van den Dobbelsteen, Frank Willem Jansen
BACKGROUND: During the implementation of new interventions (i.e., surgical devices and technologies) in the operating room, surgical safety might be compromised. Current safety measures are insufficient in detecting safety hazards during this process. The aim of the study was to observe whether surgical teams are capable of measuring surgical safety, especially with regard to the introduction of new interventions. METHODS: A Surgical Safety Questionnaire was developed that had to be filled out directly postoperative by three surgical team members...
January 19, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29352381/myocardial-perfusion-in-patients-with-suspected-coronary-artery-disease-comparison-between-320-mdct-and-rubidium-82-pet
#7
Roberto Nery Dantas, Antonildes Nascimento Assuncao, Ismar Aguiar Marques, Mateus Guimaraes Fahel, Cesar Higa Nomura, Luiz Francisco Rodrigues Avila, Maria Clementina Pinto Giorgi, Jose Soares, Jose Claudio Meneghetti, Jose Rodrigues Parga
OBJECTIVES: Despite advances in non-invasive myocardial perfusion imaging (MPI) evaluation, computed tomography (CT) multiphase MPI protocols have not yet been compared with the highly accurate rubidium-82 positron emission tomography (82RbPET) MPI. Thus, this study aimed to evaluate agreement between 82RbPET and 320-detector row CT (320-CT) MPI using a multiphase protocol in suspected CAD patients. METHODS: Forty-four patients referred for MPI evaluation were prospectively enrolled and underwent dipyridamole stress 82RbPET and multiphase 320-CT MPI (five consecutive volumetric acquisitions during stress)...
January 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29352348/metarhizium-anisopliae-s-l-modulation-of-lipid-metabolism-during-tick-infection-is-independent-of-ampk-and-erk-pathways
#8
Fillipe A Sá, Caio Junior B Coutinho-Rodrigues, Isabele C Angelo, Jéssica P Fiorotti, Georgia C Atella, Vânia Rita E P Bittencourt, Mário Alberto C Silva-Neto
Despite the importance of fat body in metabolism of arthropods, studies in ticks are scarce. This study evaluated the lipid composition and activation of extracellular signal-regulated protein kinase (ERK) and AMP-activated protein kinase (AMPK) enzymes in Rhipicephalus microplus fat body after infection with different isolates of the fungus Metarhizium anisopliae sensu lato (Metschnikoff, 1879) Sorokin, 1883. The isolates CG 32, GC 112, GC 148, GC 347, and GC 629 were inoculated as viable or non-viable conidia in the ticks...
January 19, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29351811/rate-and-determinants-of-non-adherence-to-a-gluten-free-diet-and-nutritional-status-assessment-in-children-and-adolescents-with-celiac-disease-in-a-tertiary-brazilian-referral-center-a-cross-sectional-and-retrospective-study
#9
Maraci Rodrigues, Glauce Hiromi Yonaminez, Carla Aline Satiro
BACKGROUND: Compliance with a gluten-free diet (GFD) is difficult at all ages but particularly for teenagers due to social, cultural, economic, and practical pressures. The multidisciplinary team responsible for the treatment of patients with celiac disease and give support to their parents plays a special role on strengthening GFD and assessing the nutritional and physical health. METHODS: A cross-sectional and retrospective study including patients under 20 years of age, with biopsy-confirmed CD, followed regularly at the Department of Pediatrics, Division of Gastroenterology, Hospital das Clínicas, University of Sao Paulo, School of Medicine, Sao Paulo, Brazil, were surveyed using a questionnaire and serologic test applied between November 2011 and February 2012...
January 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29351494/factors-associated-with-sarcopenia-in-patients-with-colorectal-cancer
#10
Bianca Umbelino de Souza, Nilian Carla Silva Souza, Renata Brum Martucci, Viviane Dias Rodrigues, Nivaldo Barroso de Pinho, Maria Cristina Gonzalez, Carla Maria Avesani
Introduction; Sarcopenia are frequently observed in cancer patients and was associated with poor prognosis. Objectives; to determine the association of nutritional status, body composition, and clinic parameters with sarcopenia in patients with colorectal cancer (CRC). Methods; We conducted a cross-sectional study of 197 patients with CRC. The sarcopenia elements, including lumbar skeletal muscle index (SMI), handgrip strength, and gait speed were measured. The SMI was assessed by computed tomography at third lumbar vertebra...
January 19, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29351158/physical-performance-measures-of-flexibility-hip-strength-lower-limb-power-and-trunk-endurance-in-healthy-navy-cadets-normative-data-and-differences-between-sex-and-limb-dominance
#11
Thiago Jambo Alves Lopes, Milena Simic, Daniel de Souza Alves, Priscila Dos Santos Bunn, Allan Inoue Rodrigues, Bruno de Souza Terra, Maicom da Silva Lima, Fabrício Miranda Ribeiro, Patrick Vilão, Evangelos Pappas
The objectives were to provide normative data on commonly used physical performance tests that may be associated with musculoskeletal injuries in Navy cadets, and assess for sex and limb dominance differences. A large cohort of Navy cadets were assessed for physical performance tests of flexibility (ankle dorsiflexion range of motion and sit and reach), isometric hip strength, lower limb power (single leg hop), and trunk endurance (plank and side plank tests). Besides providing normative data tables, sex and limb dominance differences were assessed by a two-way mixed ANOVA...
January 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29348648/specific-cyclic-adp-ribose-phosphohydrolase-obtained-by-mutagenic-engineering-of-mn2-dependent-adp-ribose-cdp-alcohol-diphosphatase
#12
João Meireles Ribeiro, José Canales, Alicia Cabezas, Joaquim Rui Rodrigues, Rosa María Pinto, Iralis López-Villamizar, María Jesús Costas, José Carlos Cameselle
Cyclic ADP-ribose (cADPR) is a messenger for Ca2+ mobilization. Its turnover is believed to occur by glycohydrolysis to ADP-ribose. However, ADP-ribose/CDP-alcohol diphosphatase (ADPRibase-Mn) acts as cADPR phosphohydrolase with much lower efficiency than on its major substrates. Recently, we showed that mutagenesis of human ADPRibase-Mn at Phe37, Leu196 and Cys253 alters its specificity: the best substrate of the mutant F37A + L196F + C253A is cADPR by a short difference, Cys253 mutation being essential for cADPR preference...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348479/prime-boost-vaccination-with-recombinant-protein-and-adenovirus-vector-expressing-plasmodium-vivax-circumsporozoite-protein-csp-partially-protects-mice-against-pb-pv-sporozoite-challenge
#13
Tarsila Mendes de Camargo, Elisângela Oliveira de Freitas, Alba Marina Gimenez, Luciana Chagas Lima, Karina de Almeida Caramico, Kátia Sanches Françoso, Oscar Bruna-Romero, Chiara Andolina, François Nosten, Laurent Rénia, Hildegund C J Ertl, Ruth S Nussenzweig, Victor Nussenzweig, Mauricio M Rodrigues, Arturo Reyes-Sandoval, Irene S Soares
Vaccine development against Plasmodium vivax malaria lags behind that for Plasmodium falciparum. To narrow this gap, we administered recombinant antigens based on P. vivax circumsporozoite protein (CSP) to mice. We expressed in Pichia pastoris two chimeric proteins by merging the three central repeat regions of different CSP alleles (VK210, VK247, and P. vivax-like). The first construct (yPvCSP-AllFL) contained the fused repeat regions flanked by N- and C-terminal regions. The second construct (yPvCSP-AllCT) contained the fused repeat regions and the C-terminal domain, plus RI region...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348181/intensity-of-exposure-to-pulmonary-tuberculosis-determines-risk-of-tuberculosis-infection-and-disease
#14
Carlos Acuña-Villaorduña, Edward C Jones-López, Geisa Fregona, Patricia Marques-Rodrigues, Mary Gaeddert, Carolina Geadas, David Jamil Hadad, Laura F White, Lucilia Pereira Dutra Molina, Solange Vinhas, Rodrigo Ribeiro-Rodrigues, Padmini Salgame, Moises Palaci, David Alland, Jerrold J Ellner, Reynaldo Dietze
Household contacts of pulmonary tuberculosis (TB) patients are at increased risk of TB infection and disease. However, their risk in relation to the intensity of exposure remains unknown.We studied smear-positive TB cases and their household contacts in Vitória, Brazil. We collected clinical, demographic and radiographic information from TB cases, and obtained tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT) results from household contacts. We measured intensity of exposure using a proximity score and sleep location in relation to the TB index case and defined infection by TST ≥10 mm or QFT ≥0...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29347940/domestic-feline-contribution-in-the-transmission-of-sporothrix-in-rio-de-janeiro-state-brazil-a-comparison-between-infected-and-non-infected-populations
#15
Pãmella A Macêdo-Sales, Simone R L S Souto, Carolina A Destefani, Ricardo P Lucena, Ricardo Luiz D Machado, Marcia R Pinto, Anderson M Rodrigues, Leila M Lopes-Bezerra, Elisabeth M S Rocha, Andréa Regina S Baptista
BACKGROUND: Sporotrichosis is a neglected zoonosis caused by pathogenic fungi belonging to the Sporothrix schenckii complex. In Rio de Janeiro state, this disease reached an epidemic status with over 4700 domestic felines and around 4000 humans affected since the mid-90s. The present study evaluated clinical and epidemiological aspects and also the frequency of colonization and infection by these fungi in healthy cats and among those with suspicious cutaneous lesions, inhabiting four Rio de Janeiro state distinct areas...
January 18, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29347429/collapse-transition-in-polymer-models-with-multiple-monomers-per-site-and-multiple-bonds-per-edge
#16
Nathann T Rodrigues, Tiago J Oliveira
We present results from extensive Monte Carlo simulations of polymer models where each lattice site can be visited by up to K monomers and no restriction is imposed on the number of bonds on each lattice edge. These multiple monomer per site (MMS) models are investigated on the square and cubic lattices, for K=2 and 3, by associating Boltzmann weights ω_{0}=1, ω_{1}=e^{β_{1}}, and ω_{2}=e^{β_{2}} to sites visited by 1, 2, and 3 monomers, respectively. Two versions of the MMS models are considered for which immediate reversals of the walks are allowed (RA) or forbidden (RF)...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347162/scaling-properties-of-multilayer-random-networks
#17
J A Méndez-Bermúdez, Guilherme Ferraz de Arruda, Francisco A Rodrigues, Yamir Moreno
Multilayer networks are widespread in natural and manmade systems. Key properties of these networks are their spectral and eigenfunction characteristics, as they determine the critical properties of many dynamics occurring on top of them. Here, we numerically demonstrate that the normalized localization length β of the eigenfunctions of multilayer random networks follows a simple scaling law given by β=x^{*}/(1+x^{*}), with x^{*}=γ(b_{eff}^{2}/L)^{δ}, δ∼1, and b_{eff} being the effective bandwidth of the adjacency matrix of the network, whose size is L...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346775/brd4-promotes-dna-repair-and-mediates-the-formation-of-tmprss2-erg-gene-rearrangements-in-prostate-cancer
#18
Xiangyi Li, GuemHee Baek, Susmita G Ramanand, Adam Sharp, Yunpeng Gao, Wei Yuan, Jon Welti, Daniel N Rodrigues, David Dolling, Ines Figueiredo, Semini Sumanasuriya, Mateus Crespo, Adam Aslam, Rui Li, Yi Yin, Bipasha Mukherjee, Mohammed Kanchwala, Ashley M Hughes, Wendy S Halsey, Cheng-Ming Chiang, Chao Xing, Ganesh V Raj, Sandeep Burma, Johann de Bono, Ram S Mani
BRD4 belongs to the bromodomain and extraterminal (BET) family of chromatin reader proteins that bind acetylated histones and regulate gene expression. Pharmacological inhibition of BRD4 by BET inhibitors (BETi) has indicated antitumor activity against multiple cancer types. We show that BRD4 is essential for the repair of DNA double-strand breaks (DSBs) and mediates the formation of oncogenic gene rearrangements by engaging the non-homologous end joining (NHEJ) pathway. Mechanistically, genome-wide DNA breaks are associated with enhanced acetylation of histone H4, leading to BRD4 recruitment, and stable establishment of the DNA repair complex...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346403/prime-incision-a-minimally-invasive-approach-to-breast-cancer-surgical-treatment-a-2-cohort-retrospective-comparison-with-conventional-breast-conserving-surgery
#19
Silvio Eduardo Bromberg, Patricia Rodrigues Alves de Figueiredo Moraes, Felipe Ades
The prime incision technique is an oncoplastic surgery aimed to remove both the breast tumor and the sentinel lymph node through one incision, thus providing better aesthetic results than the conventional breast conservative two incision technique. We retrospectively evaluated 2 cohorts of 60 consecutive breast cancer patients operated by either conventional breast conservative surgery (N = 26) or one incision surgery (N = 34). There were no recurrence or death events observed in any group. No difference was seen regarding the incidence of surgical complications...
2018: PloS One
https://www.readbyqxmd.com/read/29346088/intense-olfactory-stimulation-blocks-seizures-in-an-experimental-model-of-epilepsy
#20
Polianna Delfino-Pereira, Poliana Bertti-Dutra, Eduardo Henrique de Lima Umeoka, José Antônio Cortes de Oliveira, Victor Rodrigues Santos, Artur Fernandes, Simone Saldanha Marroni, Flávio Del Vecchio, Norberto Garcia-Cairasco
There are reports of patients whose epileptic seizures are prevented by means of olfactory stimulation. Similar findings were described in animal models of epilepsy, such as the electrical kindling of amygdala, where olfactory stimulation with toluene (TOL) suppressed seizures in most rats, even when the stimuli were 20% above the threshold to evoke seizures in already kindled animals. The Wistar Audiogenic Rat (WAR) strain is a model of tonic-clonic seizures induced by acute acoustic stimulation, although it also expresses limbic seizures when repeated acoustic stimulation occurs - a process known as audiogenic kindling (AK)...
January 12, 2018: Epilepsy & Behavior: E&B
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