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https://www.readbyqxmd.com/read/28527955/neuroprotective-effect-of-the-alpha-7-nicotinic-receptor-agonist-pha-543613-in-an-in-vivo-excitotoxic-adult-rat-model
#1
Laura Foucault-Fruchard, Aurélie Doméné, Guylène Page, Marguerite Windsor, Patrick Emond, Nuno Rodrigues, Frédéric Dollé, Annelaure Damont, Frédéric Buron, Sylvain Routier, Sylvie Chalon, Daniel Antier
Neuroinflammation is a key component of the pathophysiology of neurodegenerative diseases. The link between nicotine intake and positive outcome has been established, suggesting a role played by nicotinic receptors (nAChRs), especially α7nAChRs. The objective of this study was to evaluate the potential dose effects of PHA 543613 on neuron survival and striatal microglial activation in a rat model of brain excitotoxicity. A preliminary study was performed in vitro to confirm PHA 543613 agonist properties on α7nAChRs...
May 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28527839/modulation-of-matrix-metalloproteinase-14-tissue-inhibitor-of-metalloproteinase-3-tissue-inhibitor-of-metalloproteinase-4-and-inducible-nitric-oxide-synthase-in-the-development-of-periapical-lesions
#2
Lorena Teodoro de Castro Cassanta, Virmondes Rodrigues, Jose Roberto Violatti-Filho, Benedito Alves Teixeira Neto, Vinícius Marques Tavares, Eduarda Castelo Branco Araujo Bernal, Danila Malheiros Souza, Marcelo Sivieri Araujo, Sanivia Aparecida de Lima Pereira, Denise Bertulucci Rocha Rodrigues
INTRODUCTION: Periapical cysts and granulomas are chronic lesions caused by an inflammatory immune response against microbial challenge in the root canal. Different cell types, cytokines, and molecules have been associated with periapical lesion formation and expansion. Therefore, because of the chronic inflammatory state of these lesions, the aim of this study was to evaluate the in situ expression of matrix metalloproteinase (MMP)-14 and -19, tissue inhibitor of metalloproteinase (TIMP)-3 and -4, CD68, and inducible nitric oxide synthase (iNOS) in periapical cysts and granulomas...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28527785/the-effectiveness-of-a-fixed-dose-combination-pour-on-formulation-of-1-25-fipronil-and-2-5-fluazuron-against-economically-important-ectoparasites-and-associated-pharmacokinetics-in-cattle
#3
Welber Daniel Zanetti Lopes, Rafael Marin Chiummo, Luis Fernando Vettorato, Daniel de Castro Rodrigues, Rafael Bazaglia Sonada
The present work consisted of eight studies to evaluate the ectoparasiticidal spectrum and determine the pharmacokinetic parameters of a pour-on combination of fipronil 1.25mg/kg+fluazuron 2.5mg/kg for cattle against Rhipicephalus microplus, Haematobia irritans and the larvae of Dermatobia hominis and Cochliomyia hominivorax. The analysis fipronil and fluazuron were performed by liquid chromatography using a mass detector for the detection and quantification of analytes (LC-MS/MS). Additionally, in two of these studies, the animals were artificially infested with R...
May 17, 2017: Parasitology International
https://www.readbyqxmd.com/read/28527729/the-hospitalization-profiles-of-patients-with-or-without-diabetes-treated-for-nontraumatic-lower-extremity-amputation-in-ribeir%C3%A3-o-preto-s%C3%A3-o-paulo-state-brazil-2001-2008
#4
Flávia F L Rodrigues, Domingos Alves, Carla R S Teixeira, Clarissa C A Arrelias, Maria T C G Torquato, Manoel A Santos, Maria Lucia Zanetti
The aim of this retrospective study was to assess the hospitalizations of patients with or without diabetes mellitus (DM) who underwent nontraumatic lower extremity amputation (NLEA) with regard to demographic and hospitalization-related variables. It is a high proportion of hospital beds in developing countries, for patients with diabetes mellitus with lower extremity complications. Nontraumatic amputations of lower extremities rates is an important indicator to assess the effectiveness of efforts to reduce chronic complications related to diabetic foot...
June 2017: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/28527693/two-hit-model-of-schizophrenia-induced-by-neonatal-immune-activation-and-peripubertal-stress-in-rats-study-of-sex-differences-and-brain-oxidative-alterations
#5
Aline Santos Monte, Bruna Stefânia Ferreira Mello, Vládia Célia Moreira Borella, Tatiane da Silva Araujo, Francisco Eliclécio Rodrigues da Silva, Francisca Cléa F de Sousa, Antônio Carlos Pinheiro de Oliveira, Clarissa Severino Gama, Mary V Seeman, Silvânia Maria Mendes Vasconcelos, David Freitas De Lucena, Danielle Macêdo
Schizophrenia is considered to be a developmental disorder with distinctive sex differences. Aiming to simulate the vulnerability of the third trimester of human pregnancy to the developmental course of schizophrenia, an animal model was developed, using neonatal poly(I:C) as a first-hit, and peripubertal stress as a second-hit, i.e. a two-hit model. Since, to date, there have been no references to sex differences in the two-hit model, our study sought to determine sex influences on the development of behavior and brain oxidative change in adult rats submitted to neonatal exposure to poly(I:C) on postnatal days 5-7 as well as peripubertal unpredictable stress (PUS)...
May 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28527479/-biliary-anastomosis-in-liver-transplantation-with-or-without-t-tube
#6
Janine Carmelino, Susana Rodrigues, Hugo Pinto Marques, Vasco Ribeiro, Daniel Virella, Marta Alves, Américo Martins, Eduardo Barroso
INTRODUCTION: Biliary complications occur in 10-30% of liver transplants. The aim of this study was to compare the incidence of these complications in liver transplants when the T-tube was or was not used during the biliary anastomosis. MATERIAL AND METHODS: Analysis of 2 groups of patients undergoing liver transplantation between 2008 and 2012. Patients were divided considering if the T-tube was used (G1) or if it was not (G2). We sought explanatory models of the occurrence of biliary complications by logistic regression, including the variables identified in the univariate analysis...
February 27, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28527475/the-oximapa-study-hypertension-control-by-abpm-and-association-with-sleep-apnea-syndrome-by-pulse-oximetry
#7
Tiago Maricoto, Eurico Alves Rodrigues Silva, Pedro Damião, José Mesquita Bastos
INTRODUCTION: Ambulatory blood pressure monitoring by automatic device is the best blood pressure evaluation method and sleep apnea syndrome is the leading cause of poor control. Oximetry allows screening these individuals but its usefulness has been poorly explored in Primary Health Care. The aim was to evaluate the blood pressure control at the office and with ambulatory blood pressure monitoring by automatic device and to relate it to sleep apnea syndrome. MATERIAL AND METHODS: We selected a sample of 50 participants, representative of 3036 hypertensive patients...
February 27, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28527140/effect-of-tannery-effluent-on-oxidative-status-of-brain-structures-and-liver-of-rodents
#8
Felipe Dos Santos Moysés, Karine Bertoldi, Viviane Rostirola Elsner, Laura Reck Cechinel, Carla Basso, Simone Stülp, Marco Antônio Siqueira Rodrigues, Ionara Rodrigues Siqueira
Oxidative stress has been considered as a central mechanism of toxicity induced by xenobiotics. Previously, it was demonstrated that mice exposed to tannery effluent showed an anxiety-like behavior, without any comparable behavioral effects in rats. The aim of the present study was to investigate the impact of tannery wastewater on oxidative status in in vitro and in vivo assays with two mammal species, mice and rats. Specifically, homogenates of two brain areas and the liver were incubated with tannery wastewater; reactive species and lipid peroxidation levels and antioxidant enzyme activities were detected...
May 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28527122/effects-of-cigarette-smoke-exposure-during-suckling-on-food-intake-fat-mass-hormones-and-biochemical-profile-of-young-and-adult-female-rats
#9
Patricia Cristina Lisboa, Patricia Novaes Soares, Thamara Cherem Peixoto, Janaine Cavalcanti Carvalho, Camila Calvino, Vanessa Silva Tavares Rodrigues, Dayse Nascimento Bernardino, Viviane Younes-Rapozo, Alex Christian Manhães, Elaine de Oliveira, Egberto Gaspar de Moura
PURPOSE: Children from smoking mothers have a higher risk of developing obesity and associated comorbidities later in life. Different experimental models have been used to assess the mechanisms involved with this increased risk. Using a rat model of neonatal nicotine exposure via implantation of osmotic minipumps in lactating dams, we have previously shown marked sexual dimorphisms regarding metabolic and endocrine outcomes in the adult progeny. Considering that more than four thousand substances are found in tobacco smoke besides nicotine, we then studied a rat model of neonatal tobacco smoke exposure: adult male offspring had hyperphagia, obesity, hyperglycemia, hypertriglyceridemia, secondary hyperthyroidism and lower adrenal hormones...
May 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28526068/heat-pretreatment-of-canine-samples-to-evaluate-efficacy-of-imidacloprid%C3%A2-%C3%A2-moxidectin-and-doxycycline-in-heartworm-treatment
#10
Alexandre José Rodrigues Bendas, Flavya Mendes-de-Almeida, Cristiano Von Simson, Norma Labarthe
BACKGROUND: Considering the recent information on the increase of Dirofilaria immitis antigen detection by rapid assays in canine blood samples after heat treatment, the proposal that immune complexes block D. immitis antigen detection and that macrocyclic lactone + doxycycline (alternative protocol) might lead to increased production of those immune complexes, resulting in the erroneous diagnosis of adult worm elimination, and that there is no recommended adulticide marketed in Brazil, a study was performed to evaluate the interference of moxidectin + doxycycline (moxi-doxy) on diagnostic procedures when heartworm positive dogs are treated with this alternative protocol...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28525867/evaluation-of-alternative-environmentally-friendly-matrix-solid-phase-dispersion-solid-supports-for-the-simultaneous-extraction-of-15-pesticides-of-different-chemical-classes-from-drinking-water-treatment-sludge
#11
Karina Lotz Soares, Maristela Barnes Rodrigues Cerqueira, Sergiane Souza Caldas, Ednei Gilberto Primel
This study describes the development, optimization and validation of a method for the extraction of 15 pesticides of different chemical classes in drinking water treatment sludge (DWTS) by vortex-assisted Matrix Solid Phase Dispersion (MSPD) with determination by gas chromatography coupled to mass spectrometry. It focused on the application of alternative and different solid supports to the extraction step of the MSPD. The main parameters that influenced the extraction were studied in order to obtain better recovery responses...
May 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28525655/genetic-parameters-and-path-analysis-in-cowpea-genotypes-grown-in-the-cerrado-pantanal-ecotone
#12
K V Lopes, P E Teodoro, F A Silva, M T Silva, R L Fernandes, T C Rodrigues, T C Faria, A M Corrêa
Estimating genetic parameters in plant breeding allows us to know the population potential for selecting and designing strategies that can maximize the achievement of superior genotypes. The objective of this study was to evaluate the genetic potential of a population of 20 cowpea genotypes by estimating genetic parameters and path analysis among the traits to guide the selection strategies. The trial was conducted in randomized block design with four replications. Its morphophysiological components, components of green grain production and dry grain yield were estimated from genetic use and correlations between the traits...
May 18, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28525651/selecting-elephant-grass-families-and-progenies-to-produce-bioenergy-through-mixed-models-reml-blup
#13
E V Rodrigues, R F Daher, A Dos Santos, M Vivas, J C Machado, G do A Gravina, Y P de Souza, A K Vidal, A Dos S Rocha, R S Freitas
Brazil has great potential to produce bioenergy since it is located in a tropical region that receives high incidence of solar energy and presents favorable climatic conditions for such purpose. However, the use of bioenergy in the country is below its productivity potential. The aim of the current study was to select full-sib progenies and families of elephant grass (Pennisetum purpureum S.) to optimize phenotypes relevant to bioenergy production through mixed models (REML/BLUP). The circulating diallel-based crossing of ten elephant grass genotypes was performed...
May 18, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28525268/rational-design-of-novel-allosteric-dihydrofolate-reductase-inhibitors-showing-antibacterial-effects-on-drug-resistant-e-coli-escape-variants
#14
Bharath Srinivasan, João V Rodrigues, Sam Tonddast-Navaei, Eugene Shakhnovich, Jeffrey Skolnick
In drug-discovery, systematic variations of substituents on a common scaffold and bioisosteric replacements are often used to generate diversity and obtain molecules with better biological effects. However, this could saturate the small-molecule diversity pool resulting in drug-resistance. On the other hand, conventional drug-discovery relies on targeting known pockets on protein surfaces leading to drug resistance by mutations of critical pocket residues. Here, we present a two-pronged strategy of designing novel drugs that target unique pockets on a protein's surface to overcome the above problems...
May 19, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28524774/cytotoxicity-and-anti-leishmania-amazonensis-activity-of-citrus-sinensis-leaf-extracts
#15
Andreza R Garcia, Ana Claudia F Amaral, Mariana M B Azevedo, Suzana Corte-Real, Rosana C Lopes, Celuta S Alviano, Anderson S Pinheiro, Alane B Vermelho, Igor A Rodrigues
CONTEXT: Leishmania amazonensis is the main agent of diffuse cutaneous leishmaniasis, a disease characterized by lesional polymorphism and the commitment of skin surface. Previous reports demonstrated that the Citrus genus possess antimicrobial activity. OBJECTIVE: This study evaluated the anti-L. amazonensis activity of Citrus sinensis (L.) Osbeck (Rutaceae) extracts. MATERIALS AND METHODS: Citrus sinensis dried leaves were subjected to maceration with hexane (CH), ethyl acetate (CEA), dichloromethane/ethanol (CD/Et - 1:1) or ethanol/water (CEt/W - 7:3)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28524728/a-reduction-in-dna-damage-in-neural-tissue-and-peripheral-blood-of-old-mice-treated-with-caffeine
#16
Adriani Paganini Damiani, Michelle Lima Garcez, Larissa Letieli de Abreu, Taís Helena Tavares, Carina Rodrigues Boeck, Vanessa Moraes de Andrade
Studies on caffeine consumption have shown a negative correlation with development of some diseases with subsequent beneficial manifestations. Our aim was to assess the effects of caffeine on peripheral blood and neural tissue DNA in young adult and aged mice. Male Swiss mice (age 2-3 or 16-18 months, respectively) were treated with a caffeine solution (0.3 g/l) for 4 weeks, while controls received water. After the treatments, blood and hippocampal cells (for a comet assay) and femurs (for a micronucleus [MN] test) were collected...
May 19, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28524669/observation-of-five-new-narrow-%C3%AE-_-c-0-states-decaying-to-%C3%AE-_-c-k
#17
R Aaij, B Adeva, M Adinolfi, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, S Ali, G Alkhazov, P Alvarez Cartelle, A A Alves, S Amato, S Amerio, Y Amhis, L An, L Anderlini, G Andreassi, M Andreotti, J E Andrews, R B Appleby, F Archilli, P d'Argent, J Arnau Romeu, A Artamonov, M Artuso, E Aslanides, G Auriemma, M Baalouch, I Babuschkin, S Bachmann, J J Back, A Badalov, C Baesso, S Baker, V Balagura, W Baldini, A Baranov, R J Barlow, C Barschel, S Barsuk, W Barter, F Baryshnikov, M Baszczyk, V Batozskaya, B Batsukh, V Battista, A Bay, L Beaucourt, J Beddow, F Bedeschi, I Bediaga, A Beiter, L J Bel, V Bellee, N Belloli, K Belous, I Belyaev, E Ben-Haim, G Bencivenni, S Benson, S Beranek, A Berezhnoy, R Bernet, A Bertolin, C Betancourt, F Betti, M-O Bettler, M van Beuzekom, Ia Bezshyiko, S Bifani, P Billoir, A Birnkraut, A Bitadze, A Bizzeti, T Blake, F Blanc, J Blouw, S Blusk, V Bocci, T Boettcher, A Bondar, N Bondar, W Bonivento, I Bordyuzhin, A Borgheresi, S Borghi, M Borisyak, M Borsato, F Bossu, M Boubdir, T J V Bowcock, E Bowen, C Bozzi, S Braun, T Britton, J Brodzicka, E Buchanan, C Burr, A Bursche, J Buytaert, S Cadeddu, R Calabrese, M Calvi, M Calvo Gomez, A Camboni, P Campana, D H Campora Perez, L Capriotti, A Carbone, G Carboni, R Cardinale, A Cardini, P Carniti, L Carson, K Carvalho Akiba, G Casse, L Cassina, L Castillo Garcia, M Cattaneo, G Cavallero, R Cenci, D Chamont, M Charles, Ph Charpentier, G Chatzikonstantinidis, M Chefdeville, S Chen, S F Cheung, V Chobanova, M Chrzaszcz, A Chubykin, X Cid Vidal, G Ciezarek, P E L Clarke, M Clemencic, H V Cliff, J Closier, V Coco, J Cogan, E Cogneras, V Cogoni, L Cojocariu, P Collins, A Comerma-Montells, A Contu, A Cook, G Coombs, S Coquereau, G Corti, M Corvo, C M Costa Sobral, B Couturier, G A Cowan, D C Craik, A Crocombe, M Cruz Torres, S Cunliffe, R Currie, C D'Ambrosio, F Da Cunha Marinho, E Dall'Occo, J Dalseno, P N Y David, A Davis, K De Bruyn, S De Capua, M De Cian, J M De Miranda, L De Paula, M De Serio, P De Simone, C T Dean, D Decamp, M Deckenhoff, L Del Buono, H-P Dembinski, M Demmer, A Dendek, D Derkach, O Deschamps, F Dettori, B Dey, A Di Canto, P Di Nezza, H Dijkstra, F Dordei, M Dorigo, A Dosil Suárez, A Dovbnya, K Dreimanis, L Dufour, G Dujany, K Dungs, P Durante, R Dzhelyadin, M Dziewiecki, A Dziurda, A Dzyuba, N Déléage, S Easo, M Ebert, U Egede, V Egorychev, S Eidelman, S Eisenhardt, U Eitschberger, R Ekelhof, L Eklund, S Ely, S Esen, H M Evans, T Evans, A Falabella, N Farley, S Farry, R Fay, D Fazzini, D Ferguson, G Fernandez, A Fernandez Prieto, F Ferrari, F Ferreira Rodrigues, M Ferro-Luzzi, S Filippov, R A Fini, M Fiore, M Fiorini, M Firlej, C Fitzpatrick, T Fiutowski, F Fleuret, K Fohl, M Fontana, F Fontanelli, D C Forshaw, R Forty, V Franco Lima, M Frank, C Frei, J Fu, W Funk, E Furfaro, C Färber, A Gallas Torreira, D Galli, S Gallorini, S Gambetta, M Gandelman, P Gandini, Y Gao, L M Garcia Martin, J García Pardiñas, J Garra Tico, L Garrido, P J Garsed, D Gascon, C Gaspar, L Gavardi, G Gazzoni, D Gerick, E Gersabeck, M Gersabeck, T Gershon, Ph Ghez, S Gianì, V Gibson, O G Girard, L Giubega, K Gizdov, V V Gligorov, D Golubkov, A Golutvin, A Gomes, I V Gorelov, C Gotti, E Govorkova, R Graciani Diaz, L A Granado Cardoso, E Graugés, E Graverini, G Graziani, A Grecu, R Greim, P Griffith, L Grillo, B R Gruberg Cazon, O Grünberg, E Gushchin, Yu Guz, T Gys, C Göbel, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, S C Haines, B Hamilton, X Han, S Hansmann-Menzemer, N Harnew, S T Harnew, J Harrison, M Hatch, J He, T Head, A Heister, K Hennessy, P Henrard, L Henry, E van Herwijnen, M Heß, A Hicheur, D Hill, C Hombach, P H Hopchev, Z-C Huard, W Hulsbergen, T Humair, M Hushchyn, D Hutchcroft, M Idzik, P Ilten, R Jacobsson, J Jalocha, E Jans, A Jawahery, F Jiang, M John, D Johnson, C R Jones, C Joram, B Jost, N Jurik, S Kandybei, M Karacson, J M Kariuki, S Karodia, M Kecke, M Kelsey, M Kenzie, T Ketel, E Khairullin, B Khanji, C Khurewathanakul, T Kirn, S Klaver, K Klimaszewski, T Klimkovich, S Koliiev, M Kolpin, I Komarov, R Kopecna, P Koppenburg, A Kosmyntseva, S Kotriakhova, A Kozachuk, M Kozeiha, L Kravchuk, M Kreps, P Krokovny, F Kruse, W Krzemien, W Kucewicz, M Kucharczyk, V Kudryavtsev, A K Kuonen, K Kurek, T Kvaratskheliya, D Lacarrere, G Lafferty, A Lai, G Lanfranchi, C Langenbruch, T Latham, C Lazzeroni, R Le Gac, J van Leerdam, A Leflat, J Lefrançois, R Lefèvre, F Lemaitre, E Lemos Cid, O Leroy, T Lesiak, B Leverington, T Li, Y Li, Z Li, T Likhomanenko, R Lindner, F Lionetto, X Liu, D Loh, I Longstaff, J H Lopes, D Lucchesi, M Lucio Martinez, H Luo, A Lupato, E Luppi, O Lupton, A Lusiani, X Lyu, F Machefert, F Maciuc, O Maev, K Maguire, S Malde, A Malinin, T Maltsev, G Manca, G Mancinelli, P Manning, J Maratas, J F Marchand, U Marconi, C Marin Benito, M Marinangeli, P Marino, J Marks, G Martellotti, M Martin, M Martinelli, D Martinez Santos, F Martinez Vidal, D Martins Tostes, L M Massacrier, A Massafferri, R Matev, A Mathad, Z Mathe, C Matteuzzi, A Mauri, E Maurice, B Maurin, A Mazurov, M McCann, A McNab, R McNulty, B Meadows, F Meier, D Melnychuk, M Merk, A Merli, E Michielin, D A Milanes, M-N Minard, D S Mitzel, A Mogini, J Molina Rodriguez, I A Monroy, S Monteil, M Morandin, M J Morello, O Morgunova, J Moron, A B Morris, R Mountain, F Muheim, M Mulder, M Mussini, D Müller, J Müller, K Müller, V Müller, P Naik, T Nakada, R Nandakumar, A Nandi, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, M Neuner, T D Nguyen, C Nguyen-Mau, S Nieswand, R Niet, N Nikitin, T Nikodem, A Nogay, A Novoselov, D P O'Hanlon, A Oblakowska-Mucha, V Obraztsov, S Ogilvy, R Oldeman, C J G Onderwater, J M Otalora Goicochea, P Owen, A Oyanguren, P R Pais, A Palano, M Palutan, A Papanestis, M Pappagallo, L L Pappalardo, C Pappenheimer, W Parker, C Parkes, G Passaleva, A Pastore, M Patel, C Patrignani, A Pearce, A Pellegrino, G Penso, M Pepe Altarelli, S Perazzini, P Perret, L Pescatore, K Petridis, A Petrolini, A Petrov, M Petruzzo, E Picatoste Olloqui, B Pietrzyk, M Pikies, D Pinci, A Pistone, A Piucci, V Placinta, S Playfer, M Plo Casasus, T Poikela, F Polci, M Poli Lener, A Poluektov, I Polyakov, E Polycarpo, G J Pomery, S Ponce, A Popov, D Popov, B Popovici, S Poslavskii, C Potterat, E Price, J Prisciandaro, C Prouve, V Pugatch, A Puig Navarro, G Punzi, C Qian, W Qian, R Quagliani, B Rachwal, J H Rademacker, M Rama, M Ramos Pernas, M S Rangel, I Raniuk, F Ratnikov, G Raven, F Redi, S Reichert, A C Dos Reis, C Remon Alepuz, V Renaudin, S Ricciardi, S Richards, M Rihl, K Rinnert, V Rives Molina, P Robbe, A B Rodrigues, E Rodrigues, J A Rodriguez Lopez, P Rodriguez Perez, A Rogozhnikov, S Roiser, A Rollings, V Romanovskiy, A Romero Vidal, J W Ronayne, M Rotondo, M S Rudolph, T Ruf, P Ruiz Valls, J J Saborido Silva, E Sadykhov, N Sagidova, B Saitta, V Salustino Guimaraes, D Sanchez Gonzalo, C Sanchez Mayordomo, B Sanmartin Sedes, R Santacesaria, C Santamarina Rios, M Santimaria, E Santovetti, A Sarti, C Satriano, A Satta, D M Saunders, D Savrina, S Schael, M Schellenberg, M Schiller, H Schindler, M Schlupp, M Schmelling, T Schmelzer, B Schmidt, O Schneider, A Schopper, H F Schreiner, K Schubert, M Schubiger, M-H Schune, R Schwemmer, B Sciascia, A Sciubba, A Semennikov, A Sergi, N Serra, J Serrano, L Sestini, P Seyfert, M Shapkin, I Shapoval, Y Shcheglov, T Shears, L Shekhtman, V Shevchenko, B G Siddi, R Silva Coutinho, L Silva de Oliveira, G Simi, S Simone, M Sirendi, N Skidmore, T Skwarnicki, E Smith, I T Smith, J Smith, M Smith, L Soares Lavra, M D Sokoloff, F J P Soler, B Souza De Paula, B Spaan, P Spradlin, S Sridharan, F Stagni, M Stahl, S Stahl, P Stefko, S Stefkova, O Steinkamp, S Stemmle, O Stenyakin, H Stevens, S Stoica, S Stone, B Storaci, S Stracka, M E Stramaglia, M Straticiuc, U Straumann, L Sun, W Sutcliffe, K Swientek, V Syropoulos, M Szczekowski, T Szumlak, S T'Jampens, A Tayduganov, T Tekampe, G Tellarini, F Teubert, E Thomas, J van Tilburg, M J Tilley, V Tisserand, M Tobin, S Tolk, L Tomassetti, D Tonelli, S Topp-Joergensen, F Toriello, R Tourinho Jadallah Aoude, E Tournefier, S Tourneur, K Trabelsi, M Traill, M T Tran, M Tresch, A Trisovic, A Tsaregorodtsev, P Tsopelas, A Tully, N Tuning, A Ukleja, A Ustyuzhanin, U Uwer, C Vacca, V Vagnoni, A Valassi, S Valat, G Valenti, R Vazquez Gomez, P Vazquez Regueiro, S Vecchi, M van Veghel, J J Velthuis, M Veltri, G Veneziano, A Venkateswaran, T A Verlage, M Vernet, M Vesterinen, J V Viana Barbosa, B Viaud, D Vieira, M Vieites Diaz, H Viemann, X Vilasis-Cardona, M Vitti, V Volkov, A Vollhardt, B Voneki, A Vorobyev, V Vorobyev, C Voß, J A de Vries, C Vázquez Sierra, R Waldi, C Wallace, R Wallace, J Walsh, J Wang, D R Ward, H M Wark, N K Watson, D Websdale, A Weiden, M Whitehead, J Wicht, G Wilkinson, M Wilkinson, M Williams, M P Williams, M Williams, T Williams, F F Wilson, J Wimberley, M A Winn, J Wishahi, W Wislicki, M Witek, G Wormser, S A Wotton, K Wraight, K Wyllie, Y Xie, Z Xing, Z Xu, Z Yang, Z Yang, Y Yao, H Yin, J Yu, X Yuan, O Yushchenko, K A Zarebski, M Zavertyaev, L Zhang, Y Zhang, A Zhelezov, Y Zheng, X Zhu, V Zhukov, S Zucchelli
The Ξ_{c}^{+}K^{-} mass spectrum is studied with a sample of pp collision data corresponding to an integrated luminosity of 3.3  fb^{-1}, collected by the LHCb experiment. The Ξ_{c}^{+} is reconstructed in the decay mode pK^{-}π^{+}. Five new, narrow excited Ω_{c}^{0} states are observed: the Ω_{c}(3000)^{0}, Ω_{c}(3050)^{0}, Ω_{c}(3066)^{0}, Ω_{c}(3090)^{0}, and Ω_{c}(3119)^{0}. Measurements of their masses and widths are reported.
May 5, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28523647/computational-investigation-of-growth-hormone-receptor-trp169arg-heterozygous-mutation-in-a-child-with-short-stature
#18
William Farias Porto, Felipe Albuquerque Marques, Huri Brito Pogue, Maria Teresinha de Oliveira Cardoso, Maria Gabriela Rodrigues do Vale, Állan da Silva Pires, Octavio Luiz Franco, Sérgio Amorim de Alencar, Robert Pogue
Mutations in the growth hormone receptor (GHR) gene can cause disruption of the growth hormone signaling pathway, resulting in growth deficiency due to growth hormone (GH) resistance. Both recessive and apparently dominant mutations have been described in the literature. In order to shed some light on the molecular mechanism of partial growth hormone resistance caused by heterozygous mutations we performed an in-depth in silico analysis of a mutation found in a girl with a previous diagnosis of idiopathic short stature...
May 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28523625/identification-of-a-novel-putative-inhibitor-of-the-plasmodium-falciparum-purine-nucleoside-phosphorylase-exploring-the-purine-salvage-pathway-to-design-new-antimalarial-drugs
#19
Luciano Porto Kagami, Gustavo Machado das Neves, Ricardo Pereira Rodrigues, Vinicius Barreto da Silva, Vera Lucia Eifler-Lima, Daniel Fábio Kawano
Malaria, a tropical parasitic disease caused by Plasmodium spp., continues to place a heavy social burden, with almost 200 million cases and more than 580,000 deaths per year. Plasmodium falciparum purine nucleoside phosphorylase (PfPNP) can be targeted for antimalarial drug design since its inhibition kills malaria parasites both in vitro and in vivo. Although the currently known inhibitors of PfPNP, immucillins, are orally available and of low toxicity to animals and humans, to the best of our knowledge, none of these compounds has entered clinical trials for the treatment of malaria...
May 18, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28523135/use-of-co2-in-video-assisted-thoracic-surgery-and-single-lumen-endotracheal-tube-a-new-less-invasive-approach
#20
REVIEW
Javier Gallego-Poveda, Nuno Carvalho Guerra, Catarina Carvalheiro, Hugo Ferreira, André Sena, Nádia Junqueira, Tiago Rodrigues Velho, Ângelo Nobre
Carbon dioxide (CO2) has been extensively used to allow laparoscopic procedures, due to its extensive advantages in obtaining a fairly innocuous pneumoperitoneum to allow visceral dissection. Its use in video assisted thoracic surgery (VATS) has seldom been described. We present our experience in more than 100 patients, operated for various thoracic pathologies, in whom we created a surgical pneumothorax to allow different surgeries to be undertaken.
April 2017: Journal of Thoracic Disease
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