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https://www.readbyqxmd.com/read/28432808/mechanism-of-the-vasorelaxant-effect-induced-by-trans-4-methyl-%C3%AE-nitrostyrene-a-synthetic-nitroderivative-in-rat-thoracic-aorta
#1
Taylena Maria Teófilo, Loeste Arruda-Barbosa, Jussara Mathyelle Rodrigues-Silva, Joyce Karen Lima Vale, Rosivaldo Dos Santos Borges, Gloria Pinto Duarte, Pedro Jorge Caldas Magalhães, Saad Lahlou
Mechanisms underlying the vasorelaxant effects of trans-4-methyl-β-nitrostyrene (T4MeN) were studied in rat aortic rings. In endothelium-intact preparations, T4MeN fully and similarly relaxed contractions induced by phenylephrine (PHE) (IC50 = 61.41 [35.40-87.42] μM) and KCl (IC50 = 83.50 [56.63-110.50] μM). The vasorelaxant effect of T4MeN was unchanged by endothelium removal, pretreatment with L-NAME, indomethacin, tetraethylammonium, ODQ or MDL-12,330A. Under Ca(2+) -free conditions, T4MeN significantly reduced with a similar potency: (i) phasic contractions induced by PHE, but not by caffeine; (ii) contractions due to CaCl2 in aortic preparations stimulated with PHE (in the presence of verapamil) or high KCl; (iii) contractions evoked by the restoration of external Ca(2+) levels after depletion of intracellular Ca(2+) stores in the presence of thapsigargin...
April 22, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28432679/potential-use-of-cowpea-vigna-unguiculata-l-walp-stover-treated-with-white-rot-fungi-as-rabbit-feed
#2
Ederson Andrade, Victor Pinheiro, Alexandre Gonçalves, John W Cone, Guilhermina Marques, Valéria Silva, Luis Ferreira, Miguel Rodrigues
BACKGROUND: Lignin inhibitory effects within the cell wall structure constitute a serious drawback in maximizing the utilization of fibrous feedstuffs in animal feeding. In this way, treatments that promote efficient delignification of these materials must be applied. This study evaluated the potential of white-rot fungi to upgrade the nutritive value of cowpea stover for rabbits feeding. RESULTS: There was an increase in the crude protein content of all substrates as a result of fungi treatments reaching a net gain of 13% for Pleurotus citrinopileatus incubation...
April 22, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28431525/membrane-enriched-proteome-changes-and-prion-protein-expression-during-neural-differentiation-and-in-neuroblastoma-cells
#3
J A Macedo, D Schrama, I Duarte, E Tavares, J Renaut, M E Futschik, P M Rodrigues, E P Melo
BACKGROUND: The function of the prion protein, involved in the so-called prion diseases, remains a subject of intense debate and the possibility that it works as a pleiotropic protein through the interaction with multiple membrane proteins is somehow supported by recent reports. Therefore, the use of proteomic and bioinformatics combined to uncover cellular processes occurring together with changes in the expression of the prion protein may provide further insight into the putative pleiotropic role of the prion protein...
April 22, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28431366/efficacy-and-safety-of-a-video-eeg-protocol-for-genetic-generalized-epilepsies
#4
Luciana Rodrigues De Marchi, Jeana Torres Corso, Ana Carolina Zetehaku, Carina Gonçalves Pedroso Uchida, Mirian Salvadori Bittar Guaranha, Elza Márcia Targas Yacubian
INTRODUCTION: Video-EEG has been used to characterize genetic generalized epilepsies (GGE). For best performance, sleep recording, photic stimulation, hyperventilation, and neuropsychological protocols are added to the monitoring. However, risks and benefits of these video-EEG protocols are not well established. The aim of this study was to analyze the efficacy and safety of a video-EEG neuropsychological protocol (VNPP) tailored for GGE and compare its value with that of routine EEG (R-EEG)...
April 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28431322/xanthohumol-and-8-prenylnaringenin-ameliorate-diabetic-related-metabolic-dysfunctions-in-mice
#5
Raquel Costa, Ilda Rodrigues, Luísa Guardão, Sílvia Rocha-Rodrigues, Carolina Silva, José Magalhães, Manuel Ferreira-de-Almeida, Rita Negrão, Raquel Soares
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyze the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipid and glycolytic metabolism in T2DM mice model. Thirty C57Bl/6 mice were randomly divided into five groups: standard diet (control), high-fat diet (DM), high-fat diet plus ethanol (DM-Ethanol), high-fat diet plus 10 mg/L XN (DM-XN) and high-fat diet plus 10 mg/L 8PN (DM-8PN) during 20 weeks...
April 6, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28431242/structural-and-functional-analysis-of-a-%C3%AE-2-adrenergic-receptor-complex-with-grk5
#6
Konstantin E Komolov, Yang Du, Nguyen Minh Duc, Robin M Betz, João P G L M Rodrigues, Ryan D Leib, Dhabaleswar Patra, Georgios Skiniotis, Christopher M Adams, Ron O Dror, Ka Young Chung, Brian K Kobilka, Jeffrey L Benovic
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling. While a structural understanding of GPCR/G-protein and GPCR/arrestin complexes has emerged in recent years, the molecular architecture of a GPCR/GRK complex remains poorly defined. We used a comprehensive integrated approach of cross-linking, hydrogen-deuterium exchange mass spectrometry (MS), electron microscopy, mutagenesis, molecular dynamics simulations, and computational docking to analyze GRK5 interaction with the β2-adrenergic receptor (β2AR)...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28431211/oxyuricassis-coronatus-n-gen-n-sp-and-o-hexaspinatus-n-sp-oxyurida-pharyngodonidae-parasites-of-lasiancistrus-saetiger-siluriformes-loricariidae-in-freshwater-rivers-of-the-brazilian-amazon
#7
Allan Rodrigo Oliveira Rodrigues, Jeannie Nascimentodos Santos, Adriano Penha Furtado, Francisco Tiago Vasconcelos Melo
A new nematode genus is described from intestines of Lasiancistrus saetiger Ambruster from freshwater rivers in the Brazilian Amazon. Oxyuricassis n. gen. is characterized by, a cephalic hood, buccal cavity small , long oesophagus with a well-developed isthmus and a conical tail with spines. Two new species are described: O. coronatus n. sp. is characterized by the absence of lateral alae, a conical tail with truncated extremity with sclerotized projections spine-like around the tail tip, male of O. coronatus has a caudal alae sucker-like...
April 21, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28430881/stroke-in-the-young
#8
André Correia, Bruno Silva, João Manuel-Rodrigues, Nuno Jardim, Rafael Freitas
No abstract text is available yet for this article.
March 14, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28430669/low-previous-cardiovascular-risk-of-patients-with-st-elevation-myocardial-infarction
#9
Gustavo Rodrigues, Pedro de Araújo Gonçalves, Francisco Moscoso Costa, Rui Campante Teles, Dores Hélder, Luís Mariano, João Brito, Henrique Mesquita Gabriel, Manuel Almeida, Miguel Mendes
BACKGROUND: Myocardial infarction is frequently the initial form of presentation of coronary artery disease (CAD). Systemic Coronary Risk Estimation (SCORE) risk tables are used in primary prevention and provide an estimate of cardiovascular (CV) risk through known risk factors. The aim of this study was to evaluate the performance of the SCORE, calculated using data previous to the event, to estimate CV risk of a population of patients presenting with ST-elevation myocardial infarction (STEMI) as the first manifestation of CAD...
April 20, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28429368/-aralar-agc1-deficiency-a-neurodevelopmental-disorder-with-severe-impairment-of-neuronal-mitochondrial-respiration-does-not-produce-a-primary-increase-in-brain-lactate
#10
Inés Juaristi, María L García-Martin, Tiago B Rodrigues, Jorgina Satrústegui, Irene Llorente-Folch, Beatriz Pardo
ARALAR/AGC1 (aspartate-glutamate mitochondrial carrier 1) is an important component of the NADH malate-aspartate shuttle (MAS). AGC1-deficiency is a rare disease causing global cerebral hypomyelination, developmental arrest, hypotonia, and epilepsy (OMIM ID #612949); the aralar-KO mouse recapitulates the major findings in humans. This study was aimed at understanding the impact of ARALAR-deficiency in brain lactate levels as a biomarker. We report that lactate was equally abundant in wild-type and aralar-KO mouse brain in vivo at PND 17...
April 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28426907/frontal-fibrosing-alopecia-clinical-and-prognostic-classification
#11
O M Moreno-Arrones, D Saceda-Corralo, P Fonda-Pascual, A R Rodrigues-Barata, D Buendía-Castaño, A Alegre-Sánchez, C Pindado-Ortega, M Molins, D Perosanz, G Segurado-Miravalles, P Jaén, S Vañó-Galván
BACKGROUND: Frontal fibrosing alopecia (FFA) is a chronic scarring alopecia with an unpredictable evolution. There are no current classifications of this disease that may predict its prognosis. OBJECTIVE: To analyze the differences in clinical presentation and evolution of FFA patients and to create a clinical and prognostic classification METHODS: We conducted a retrospective analytical study of FFA patients. Clinical characteristics of frontal hairline recession were used as the sorting variable between patterns of presentation...
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28426648/pregnancy-swimming-causes-short-and-long-term-neuroprotection-against-hypoxia-ischemia-in-very-immature-rats
#12
Eduardo Farias Sanches, Luz Elena Duran Carabali, Andrea Tosta, Fabrício Nicola, Felipe Schmitz, André Rodrigues, Cassiana Siebert, Angela Wyse, Carlos Alexandre Netto
BACKGROUND: Hypoxia-ischemia (HI) is a major cause of neurological damage in preterm. Pregnancy swimming alters the pup's brain development. We tested the effects of swimming during pregnancy in the very immature rat brain. METHODS: Female Wistar rats (n=12) were assigned to sedentary (SE, n=6) or swimming groups (SW, n=6). From the gestational day 0 (DG0) to GD21 they performed 20 min/daily swimming sessions. HI on postnatal day 3 rat cause sensorimotor and cognitive impairments...
April 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28426404/the-ruby-crowned-tanager-tachyphonus-coronatus-vieillot-1822-passeriformes-thraupidae-as-a-new-host-for-isospora-ramphoceli-berto-flausino-luz-ferreira-lopes-2010-in-brazil
#13
Mariana Borges Rodrigues, Irlane Faria de Pinho, Lidiane Maria da Silva, Bruno doBomfim Lopes, Hermes Ribeiro Luz, Ildemar Ferreira, Carlos Wilson Gomes Lopes, Bruno Pereira Berto
Despite 12 coccidian species had been recorded from passerines of the Thraupidae family, none of them has been reported in the Parque Nacional do Itatiaia, in Southeastern Brazil. This locality is a protected area with a high degree of vulnerability, and is considered a "conservation island" of biodiversity. The aim of the current work was describe Isospora ramphoceli Berto, Flausino, Luz, Ferreira, Lopes, 2010 from ruby-crowned tanagers Tachyphonus coronatus Vieillot, 1822 in the Parque Nacional do Itatiaia...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28425939/fructose-consumption-in-the-development-of-obesity-and-the-effects-of-different-protocols-of-physical-exercise-on-the-hepatic-metabolism
#14
REVIEW
Rodrigo Martins Pereira, José Diego Botezelli, Kellen Cristina da Cruz Rodrigues, Rania A Mekary, Dennys Esper Cintra, José Rodrigo Pauli, Adelino Sanchez Ramos da Silva, Eduardo Rochete Ropelle, Leandro Pereira de Moura
Fructose consumption has been growing exponentially and, concomitant with this, the increase in the incidence of obesity and associated complications has followed the same behavior. Studies indicate that fructose may be a carbohydrate with greater obesogenic potential than other sugars. In this context, the liver seems to be a key organ for understanding the deleterious health effects promoted by fructose consumption. Fructose promotes complications in glucose metabolism, accumulation of triacylglycerol in the hepatocytes, and alterations in the lipid profile, which, associated with an inflammatory response and alterations in the redox state, will imply a systemic picture of insulin resistance...
April 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28424961/tillandsia-usneoides-a-successful-alternative-for-biomonitoring-changes-in-air-quality-due-to-a-new-highway-in-s%C3%A3-o-paulo-brazil
#15
EDITORIAL
Poliana Cardoso-Gustavson, Francine Faia Fernandes, Edenise Segala Alves, Mariana Pereira Victorio, Barbara Baesso Moura, Marisa Domingos, Caroline Albuquerque Rodrigues, Andreza Portella Ribeiro, Catarina Carvalho Nievola, Ana Maria G Figueiredo
No abstract text is available yet for this article.
April 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28424735/tongue-necrosis-secondary-to-giant-cell-arteritis-a-case-report-and-literature-review
#16
Rafael Alex Barbosa de Siqueira Sobrinho, Karolina Cayres Alvino de Lima, Helena Carvalho Moura, Mônica Modesto Araújo, Christyanne Maria Rodrigues Barreto de Assis, Pedro Alves da Cruz Gouveia
Giant cell arteritis is a form of vasculitis involving the medium- and large-sized arteries that chiefly affects older people. Clinical findings are headache, jaw claudication, fever, pain, and thickening of the temporal artery. The most feared complication is visual loss due to impairment of the ophthalmic artery and posterior ciliary arteries. This a case report of an 85-year-old male presenting with headache and jaw pain, who was admitted with tongue necrosis as an initial manifestation of giant cell arteritis...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28424146/excess-all-cause-and-influenza-attributable-mortality-in-europe-december-2016-to-february-2017
#17
Lasse S Vestergaard, Jens Nielsen, Tyra G Krause, Laura Espenhain, Katrien Tersago, Natalia Bustos Sierra, Gleb Denissov, Kaire Innos, Mikko J Virtanen, Anne Fouillet, Theodore Lytras, Anna Paldy, Janos Bobvos, Lisa Domegan, Joan O'Donnell, Matteo Scortichini, Annamaria de Martino, Kathleen England, Neville Calleja, Liselotte van Asten, Anne C Teirlinck, Ragnhild Tønnessen, Richard A White, Susana P Silva, Ana P Rodrigues, Amparo Larrauri, Inmaculada Leon, Ahmed Farah, Christoph Junker, Mary Sinnathamby, Richard G Pebody, Arlene Reynolds, Jennifer Bishop, Diane Gross, Cornelia Adlhoch, Pasi Penttinen, Kåre Mølbak
Since December 2016, excess all-cause mortality was observed in many European countries, especially among people aged ≥ 65 years. We estimated all-cause and influenza-attributable mortality in 19 European countries/regions. Excess mortality was primarily explained by circulation of influenza virus A(H3N2). Cold weather snaps contributed in some countries. The pattern was similar to the last major influenza A(H3N2) season in 2014/15 in Europe, although starting earlier in line with the early influenza season start...
April 6, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28423971/intrauterine-infection-immune-system-and-premature-birth
#18
Fernanda Rodrigues Helmo, Eduardo Arthur Rodovalho Alves, Renata Alves de Andrade Moreira, Viviane Oliveira Severino, Laura Penna Rocha, Maria Luíza Gonçalves Dos Reis Monteiro, Marlene Antônia Dos Reis, Renata Margarida Etchebehere, Juliana Reis Machado, Rosana Rosa Miranda Corrêa
Preterm birth accounts for nearly one million deaths among children under five years of age, and although its etiopathogenesis is not fully elucidated, ascending intrauterine infection and fetal inflammatory response seem to be the main triggers. The intense inflammatory response mediated by IL-1β, TNF-α, PAF, IFN-γ and IL-6, PGE2 and MMP-1 and MMP-9 causes fetal membrane damage and rupture, increased uterine contractions and biochemical and structural changes in the cervix. Furthermore, preterm neonates have deficient innate and adaptive immune responses characterized by reduced levels of IgG, opsonization and phagocytosis, as well as increased activation of Th1 cells in relation to Th2 cells...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28423379/excessive-weight-favours-skin-physiology-up-to-a-point-another-expression-of-the-obesity-paradox
#19
Luís Monteiro Monteiro Rodrigues, Lídia Palma, Osvaldo Santos, Maria Angélica Almeida, Julia Bujan, Liliana Tavares
BACKGROUND/AIMS: Recently classified as an epidemic by the WHO, obesity (as well as the state of being overweight) clearly affects significant populations across all ages. The relationship between obesity and some diseases (e.g. cardiovascular ones) is known, although many paradoxes remain to be explained. Very little information is available, however, regarding its impact on skin physiology and skin disease. This study aims to examine the influence of excessive weight on epidermal hydration and transepidermal water loss, key variables of skin water balance and skin biomechanics...
April 20, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28423089/phenotypic-and-genotypic-detection-of-candida-albicans-and-candida-dubliniensis-strains-isolated-from-oral-mucosa-of-aids-pediatric-patients
#20
Harisson Oliveira Livério, Luciana da Silva Ruiz, Roseli Santos de Freitas, Angela Nishikaku, Ana Clara de Souza, Claudete Rodrigues Paula, Carina Domaneschi
The aim of this study was to assess a collection of yeasts to verify the presence of Candida dubliniensis among strains isolated from the oral mucosa of AIDS pediatric patients which were initially characterized as Candida albicans by the traditional phenotypic method, as well as to evaluate the main phenotypic methods used in the discrimination between the two species and confirm the identification through genotypic techniques, i.e., DNA sequencing. Twenty-nine samples of C. albicans isolated from this population and kept in a fungi collection were evaluated and re-characterized...
April 13, 2017: Revista do Instituto de Medicina Tropical de São Paulo
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