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https://www.readbyqxmd.com/read/28732178/reproductive-plasticity-in-the-nematode-gyrinicola-batrachiensis-does-an-intermediate-reproductive-strategy-exist-in-sexually-reproducing-didelphic-pinworms
#1
Jasmine N Childress, Sean C Rogers, Matthew G Bolek, Gabriel J Langford
Phenotypic plasticity is a process in which multiple phenotypes arise from one genotype due to environmental selection pressures. Gyrinicola batrachiensis has a heterogeneous reproductive strategy such that females reproduce either via parthogenesis with thick-shelled eggs in a single uterus or sexual reproduction with thick and thin-shelled eggs in separate uterine horns. No evidence exists that strains of G. batrachiensis are able to switch between parthenogenetic and sexual reproduction. Thin-shelled eggs are autoinfective while thick-shelled eggs act as transmission agents once shed into the aquatic environment...
July 21, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28732127/editorial
#2
EDITORIAL
Roger Dmochowski
No abstract text is available yet for this article.
August 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28731045/renal-cell-tumors-with-clear-cell-histology-and-intact-vhl-and-chromosome-3p-a-histological-review-of-tumors-from-the-cancer-genome-atlas-database
#3
Laura Favazza, Dhananjay A Chitale, Ravi Barod, Craig G Rogers, Shanker Kalyana-Sundaram, Nallasivam Palanisamy, Nilesh S Gupta, Sean R Williamson
Clear cell renal cell carcinoma is by far the most common form of kidney cancer; however, a number of histologically similar tumors are now recognized and considered distinct entities. The Cancer Genome Atlas published data set was queried (http://cbioportal.org) for clear cell renal cell carcinoma tumors lacking VHL gene mutation and chromosome 3p loss, for which whole-slide images were reviewed. Of the 418 tumors in the published Cancer Genome Atlas clear cell renal cell carcinoma database, 387 had VHL mutation, copy number loss for chromosome 3p, or both (93%)...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28729683/a-positive-feedback-loop-mediated-by-sigma-x-enhances-expression-of-the-streptococcal-regulator-comr
#4
Rabia Khan, Roger Junges, Heidi A Åmdal, Tsute Chen, Donald A Morrison, Fernanda C Petersen
Natural transformation is used by bacteria to take up DNA from their surroundings and incorporate it into their genomes. Streptococci do so during a transient period of competence, triggered by pheromones that they produce, secrete and sense under conditions influenced by the environment. In Streptococcus mutans, Streptococcus suis, and species of the bovis, salivarius and pyogenic groups of streptococci, the pheromone XIP is sensed by the intra-cellular regulator ComR, that in turn activates the transcription of comS, encoding the XIP precursor, and of sigX, encoding the only known alternative sigma factor in streptococci...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729539/comparative-proteomic-analysis-of-human-embryonic-stem-cell-derived-and-primary-human-retinal-pigment-epithelium
#5
Heidi Hongisto, Antti Jylhä, Janika Nättinen, Jochen Rieck, Tanja Ilmarinen, Zoltán Veréb, Ulla Aapola, Roger Beuerman, Goran Petrovski, Hannu Uusitalo, Heli Skottman
Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) provide an unlimited cell source for retinal cell replacement therapies. Clinical trials using hESC-RPE to treat diseases such as age-related macular degeneration (AMD) are currently underway. Human ESC-RPE cells have been thoroughly characterized at the gene level but their protein expression profile has not been studied at larger scale. In this study, proteomic analysis was used to compare hESC-RPE cells differentiated from two independent hESC lines, to primary human RPE (hRPE) using Isobaric tags for relative quantitation (iTRAQ)...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729374/a-patient-with-a-painful-and-swollen-hand
#6
Alexander Ej Trevatt, William Maynard, Roger Adlard
No abstract text is available yet for this article.
July 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28729029/impact-of-micrornas-in-the-cellular-response-to-hypoxia
#7
Thomas Bertero, Roger Rezzonico, Nicolas Pottier, Bernard Mari
In mammalian cells, hypoxia, or inadequate oxygen availability, regulates the expression of a specific set of MicroRNAs (MiRNAs), termed "hypoxamiRs." Over the past 10 years, the appreciation of the importance of hypoxamiRs in regulating the cellular adaptation to hypoxia has grown dramatically. At the cellular level, each hypoxamiR, including the master hypoxamiR MiR-210, can simultaneously regulate expression of multiple target genes in order to fine-tune the adaptive response of cells to hypoxia. This review addresses the complex molecular regulation of MiRNAs in both physiological and pathological conditions of low oxygen adaptation and the multiple functions of hypoxamiRs in various hypoxia-associated biological processes, including apoptosis, survival, proliferation, angiogenesis, inflammation, and metabolism...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28728590/chikungunya-virus-infection-in-cynomolgus-macaques-following-intradermal-and-aerosol-exposure
#8
Chris M Cirimotich, Eric M Vela, Jennifer Garver, Roy E Barnewall, Brian D Miller, Gabriel T Meister, James V Rogers
BACKGROUND: Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeutics to protect against CHIKV infection in humans. Animal models recapitulating human disease, especially for transmission by aerosol, are needed for licensure of such medical countermeasures. METHODS: Cynomolgus macaques (CMs) were challenged by intradermal (ID) inoculation or exposure to an aerosol containing CHIKV Ross strain at different target infectious doses (10(3)-10(7) plaque forming units (PFU))...
July 20, 2017: Virology Journal
https://www.readbyqxmd.com/read/28728577/integrating-data-from-randomized-controlled-trials-and-observational-studies-to-predict-the-response-to-pregabalin-in-patients-with-painful-diabetic-peripheral-neuropathy
#9
Joe Alexander, Roger A Edwards, Alberto Savoldelli, Luigi Manca, Roberto Grugni, Birol Emir, Ed Whalen, Stephen Watt, Marina Brodsky, Bruce Parsons
BACKGROUND: More patient-specific medical care is expected as more is learned about variations in patient responses to medical treatments. Analytical tools enable insights by linking treatment responses from different types of studies, such as randomized controlled trials (RCTs) and observational studies. Given the importance of evidence from both types of studies, our goal was to integrate these types of data into a single predictive platform to help predict response to pregabalin in individual patients with painful diabetic peripheral neuropathy (pDPN)...
July 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28728505/in-vitro-comparison-of-stone-fragmentation-when-using-various-settings-with-modern-variable-pulse-holmium-lasers
#10
John Roger Bell, Kristina L Penniston, Stephen Y Nakada
INTRODUCTION AND OBJECTIVE There is limited data regarding optimal laser and energy settings during stone fragmentation. We assessed effects on fragmentation using a variety of energy and frequency settings with two laser systems. METHODS Artificial stones were created using BegoStone (Streeper et al 2016). A clear PVC tube with an inner diameter of 13mm was closed at one end with a removable plug to create the in vitro ureteral and calyceal environments. The Lumenis Pulse 120H and the Cook Rhapsody H-30 holmium lasers were studied in the calyceal and ureteral models...
July 20, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28728468/the-roles-of-chronological-age-and-time-perspective-in-memory-positivity
#11
Irene P Kan, Shaina L Garrison, Anna B Drummey, Brian E Emmert, Leeland L Rogers
The observation that older adults show enhanced cognition for emotionally positive information has been labeled the positivity effect (Reed, Chan, & Mikels, 2014). According to the Socioemotional Selectivity Theory (SST, Carstensen, 1991), a prominent lifespan development theory, cognition is strongly influenced by motivational goals, and these goals are impacted by subjective time perspective. Although the positivity effect is most commonly observed in older adults, as age usually co-varies with time perspective, the SST posits that time perspective, not age, is the key explanatory factor of positivity...
July 21, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28728165/active-multiple-myeloma-suppresses-and-typically-eliminates-coexisting-mgus
#12
John P Campbell, Jennifer L J Heaney, Sankalp Pandya, Zaheer Afzal, Martin Kaiser, Roger Owen, J Anthony Child, Walter Gregory, Gareth J Morgan, Graham H Jackson, Chris M Bunce, Mark T Drayson
BACKGROUND: Myeloma is consistently preceded by premalignant monoclonal gammopathy of undetermined significance (MGUS). In >5% of MGUS patients there is a second MGUS clone (biclonal gammopathy of undetermined significance; BGUS), yet, at myeloma diagnosis, presentation of biclonal gammopathy myeloma (BGMy) is considered less frequent, implying that myeloma eradicates coexisting MGUS. METHODS: In the largest study of its kind, we assessed BGMy frequency amongst 6399 newly diagnosed myeloma patients enrolled in recent UK clinical trials...
July 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28727913/alpha-l-fucosidase-immunoassay-for-early-detection-of-hepatocellular-carcinoma
#13
Eric Waidely, Abdulrahman Obaid Al-Youbi, Abdulaziz Saleh Omar Bashammakh, Mohammad Soror El-Shahawi, Roger M Leblanc
Detection of alpha-L-fucosidase has been shown to have relevance in diagnosing hepatocellular carcinoma. Few assays have been developed to measure this enzyme, with most relying on colorimetric techniques involving the enzyme's kinetics. While these assays are facile and quick, the sensitivity is not always sufficient for early tumor detection. To improve upon previous assays for alpha-L-fucosidase, a fluorescence based immunoassay was produced implementing an alpha-L-fucosidase specific antibody (FUCA2). The immobilization of the alpha-L-fucosidase-specific antibody onto a quartz slide was investigated with several bioconjugation approaches and an immunoassay for detection of alpha-L-fucosidase was produced...
July 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28727890/surfactant-concentration-and-type-affects-the-removal-of-escherichia-coli-from-pig-skin-during-a-simulated-handwash
#14
Dane A Jensen, Michael A Rogers, Donald W Schaffner
The effect of surfactant type and concentration on a bland soap formulations ability to remove bacteria from hands remains largely unstudied. Several combinations of surfactants and water were combined to test bacterial removal efficacy using a handwashing device (two pieces of pig skin and a mechanical motor) to simulate a handwash. A nalidixic acid resistant, non-pathogenic strain of Escherichia coli (ATCC 11229) was used. Two anionic surfactants, sodium lauryl sulfate and sodium stearoyl lactylate, and two nonionic surfactants, poloxamer 407 and sorbitan monostearate, each in concentrations of 2%, 5%, and 10% were studied...
July 20, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28727715/a-pilot-cross-sectional-study-of-postpartum-wrist-pain-in-an-urban-chinese-population-its-prevalence-and-risk-factors
#15
Regina W S Sit, Wing-Hung Tam, Dicken C C Chan, Benjamin H K Yip, Lucia W Y Tam, Lyan L Y Chow, Vincent C H Chung, Roger Y Chung, Samuel Y S Wong
BACKGROUND: Wrist pain after childbirth is commonly encountered in clinical practice. Little is known about the prevalence of this musculoskeletal disorder which is important to overall maternal health. OBJECTIVE: To examine the prevalence of and risk factors for de novo wrist pain in women after childbirth. STUDY DESIGN: A pilot cross-sectional survey. SETTING: A telephone interview was conducted 2 months after childbirth among women who delivered at a tertiary hospital in Hong Kong...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28727689/do-robots-get-burnout
#16
EDITORIAL
Frank Frizelle, Roger Mulder
No abstract text is available yet for this article.
July 21, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28727681/notes-from-the-field-cluster-of-acute-flaccid-myelitis-in-five-pediatric-patients-maricopa-county-arizona-2016
#17
Sally A Iverson, Scott Ostdiek, Siru Prasai, David M Engelthaler, Melissa Kretschmer, Nicole Fowle, Harlori K Tokhie, Janell Routh, James Sejvar, Tracy Ayers, Jolene Bowers, Shane Brady, Shannon Rogers, W Allan Nix, Ken Komatsu, Rebecca Sunenshine
No abstract text is available yet for this article.
July 21, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28727518/therapeutic-and-prognostic-implications-of-braf-v600e-in-pediatric-low-grade-gliomas
#18
Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, Ofelia Cruz, Carmen de Torres, Cheng-Ying Ho, Roger J Packer, Ruth Tatevossian, Ibrahim Qaddoumi, Julie H Harreld, James D Dalton, Jean Mulcahy-Levy, Nicholas Foreman, Matthias A Karajannis, Shiyang Wang, Matija Snuderl, Amulya Nageswara Rao, Caterina Giannini, Mark Kieran, Keith L Ligon, Maria Luisa Garre, Paolo Nozza, Samantha Mascelli, Alessandro Raso, Sabine Mueller, Theodore Nicolaides, Karen Silva, Romain Perbet, Alexandre Vasiljevic, Cécile Faure Conter, Didier Frappaz, Sarah Leary, Courtney Crane, Aden Chan, Ho-Keung Ng, Zhi-Feng Shi, Ying Mao, Elizabeth Finch, David Eisenstat, Bev Wilson, Anne Sophie Carret, Peter Hauser, David Sumerauer, Lenka Krskova, Valerie Larouche, Adam Fleming, Shayna Zelcer, Nada Jabado, James T Rutka, Peter Dirks, Michael D Taylor, Shiyi Chen, Ute Bartels, Annie Huang, David W Ellison, Eric Bouffet, Cynthia Hawkins, Uri Tabori
Purpose BRAF V600E is a potentially highly targetable mutation detected in a subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group of tumors remains unknown. Patients and Methods A combined clinical and genetic institutional study of patients with PLGGs with long-term follow-up was performed (N = 510). Clinical and treatment data of patients with BRAF V600E mutated PLGG (n = 99) were compared with a large international independent cohort of patients with BRAF V600E mutated-PLGG (n = 180)...
July 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28727295/in-memoriam-roger-tsien
#19
Alan Waggoner
No abstract text is available yet for this article.
July 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28727281/defaunation-leads-to-interaction-deficits-not-interaction-compensation-in-an-island-seed-dispersal-network
#20
Evan C Fricke, Joshua J Tewksbury, Haldre S Rogers
Following defaunation, the loss of interactions with mutualists such as pollinators or seed dispersers may be compensated through increased interactions with remaining mutualists, ameliorating the negative cascading impacts on biodiversity. Alternatively, remaining mutualists may respond to altered competition by reducing the breadth or intensity of their interactions, exacerbating negative impacts on biodiversity. Despite the importance of these responses for our understanding of the dynamics of mutualistic networks and their response to global change, the mechanism and magnitude of interaction compensation within real mutualistic networks remains largely unknown...
July 20, 2017: Global Change Biology
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