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https://www.readbyqxmd.com/read/29040866/carbon-dependent-alleviation-of-ammonia-toxicity-for-algae-cultivation-and-associated-mechanisms-exploration
#1
Qian Lu, Paul Chen, Min Addy, Renchuan Zhang, Xiangyuan Deng, Yiwei Ma, Yanling Cheng, Fida Hussain, Chi Chen, Yuhuan Liu, Roger Ruan
Ammonia toxicity in wastewater is one of the factors that limit the application of algae technology in wastewater treatment. This work explored the correlation between carbon sources and ammonia assimilation and applied a glucose-assisted nitrogen starvation method to alleviate ammonia toxicity. In this study, ammonia toxicity to Chlorella sp. was observed when NH3-N concentration reached 28.03mM in artificial wastewater. Addition of alpha-ketoglutarate in wastewater promoted ammonia assimilation, but low utilization efficiency and high cost of alpha-ketoglutarate limits its application in wastewater treatment...
September 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29040862/fast-microwave-assisted-ex-catalytic-co-pyrolysis-of-bamboo-and-polypropylene-for-bio-oil-production
#2
Yunfeng Zhao, Yunpu Wang, Dengle Duan, Roger Ruan, Liangliang Fan, Yue Zhou, Leilei Dai, Jiaqian Lv, Yuhuan Liu
The ex-catalytic co-pyrolysis of bamboo and polypropylene (PP) with HZSM-5 was investigated with microwave assistance. The influences of catalytic temperature, feedstock/catalyst ratio, and bamboo/PP ratio on the product yields and chemical components of bio-oil from the co-pyrolysis were studied. When the catalytic temperature, feedstock/catalyst ratio, and bamboo/PP ratio were 250 °C, 1:2, and 2:1, respectively, the bio-oil yield reached its maximum value at 61.62 wt%. The oxygenate proportion compounds decreased with increasing catalyst content...
September 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29040828/neuropsychological-functioning-and-brain-energetics-of-drug-resistant-mesial-temporal-lobe-epilepsy-patients
#3
Camila Moreira Osório, Alexandra Latini, Rodrigo Bainy Leal, Maria Emília Rodrigues de Oliveira Thais, Helena Dresch Vascouto, Aline Pertile Remor, Mark William Lopes, Marcelo Neves Linhares, Juliana Ben, Roberta de Paula Martins, Rui Daniel Prediger, Alexandre Ademar Hoeller, Hans Joachim Markowitsch, Peter Wolf, Kátia Lin, Roger Walz
Interictal hypometabolism is commonly measured by 18-fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) in the temporal lobe of patients with mesial temporal lobe epilepsy (MTLE-HS). Left temporal lobe interictal FDG-PET hypometabolism has been associated with verbal memory impairment, while right temporal lobe FDG-PET hypometabolism is associated with nonverbal memory impairment. The biochemical mechanisms involved in these findings remain unknown. In comparison to healthy controls (n=21), surgically treated patients with MTLE-HS (n=32, left side=17) had significant lower scores in the Rey Auditory Verbal Learning Test (RAVLT retention and delayed), Logical Memory II (LMII), Boston Naming test (BNT), Letter Fluency and Category Fluency...
October 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29040808/independently-tuning-the-biochemical-and-mechanical-properties-of-3d-hyaluronan-based-hydrogels-with-oxime-and-diels-alder-chemistry-to-culture-breast-cancer-spheroids
#4
Alexander E G Baker, Roger Y Tam, Molly S Shoichet
In order to mimic native breast cancer cell growth in vitro as spheroids, a well-defined matrix that mimics the tumor microenvironment is required. Finding a biomimetic material for 3D cell culture, other than Matrigel, has challenged the field. Since hyaluronan is naturally abundant in the tumor microenvironment and can be chemically modified, we synthesized a hyalu-ronan hydrogel with independently tunable mechanical and chemical properties for 3D culture of breast cancer cells. By modifying HA with distinct bioorthogonal functional groups, its mechanical properties are controlled by chemical crosslinking via oxime liga-tion while its biochemical properties are controlled by grafting bioactive peptides via Diels-Alder chemistry...
October 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29040668/aurora-kinase-b-a-novel-regulator-of-terf1-binding-and-telomeric-integrity
#5
Foong Lyn Chan, Benjamin Vinod, Karel Novy, Ralf B Schittenhelm, Cheng Huang, Maheshi Udugama, Juan Nunez-Iglesias, Jane I Lin, Linda Hii, Julie Chan, Hilda A Pickett, Roger J Daly, Lee H Wong
AURKB (Aurora Kinase B) is a serine/threonine kinase better known for its role at the mitotic kinetochore during chromosome segregation. Here, we demonstrate that AURKB localizes to the telomeres in mouse embryonic stem cells, where it interacts with the essential telomere protein TERF1. Loss of AURKB function affects TERF1 telomere binding and results in aberrant telomere structure. In vitro kinase experiments successfully identified Serine 404 on TERF1 as a putative AURKB target site. Importantly, in vivo overexpression of S404-TERF1 mutants results in fragile telomere formation...
October 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040598/effect-of-metformin-on-vascular-function-in-children-with-type-1-diabetes-a-12-month-randomized-controlled-trial
#6
Jemma J A Anderson, Jennifer J Couper, Lynne C Giles, Catherine E Leggett, Roger Gent, Brian Coppin, Alexia S Peña
Context: Children with type 1 diabetes have vascular dysfunction preceding atherosclerosis. Early interventions are needed to reduce cardiovascular disease. Objective: To evaluate the effect of metformin on vascular function in type 1 diabetes children. Design: 12 month double blind, randomized, placebo-controlled trial. Setting: Tertiary pediatric diabetes clinic. Participants: 90 type 1 diabetes children(8-18 years), above 50th percentile body mass index (BMI)...
October 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29036023/percutaneous-mesh-expansion-pme-a-regenerative-wound-closure-alternative
#7
Kimberly S Khouri, Eufemiano Cardoso, Roger K Khouri
BACKGROUND: Puncture wounds in the 1-mm range usually heal without scars. Stacking rows of these punctures offers a scarless method to generate tissue by mesh expansion. We developed a percutaneous mesh expansion (PME) procedure and present our experience for its wound closure application. METHODS: Over a six-year period we applied PME to 65 consecutive patients 58-101 years-old (mean, 72) with 67 full thickness calvarial defects 2.5x3-7x8cm (mean, 14cm2) that would have all required flaps for closure...
October 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29035106/does-the-hispanic-health-advantage-extend-to-better-management-of-hypertension-the-role-of-socioeconomic-status-sociobehavioral-factors-and-health-care-access
#8
Emily Bacon, Fernando Riosmena, Richard G Rogers
Hispanics in the United States (and foreign-born Hispanics in particular) have relatively favorable health given their lower socioeconomic status compared to, for example, non-Hispanic whites. This phenomenon is often called the Hispanic health paradox (HHP). This study examines whether the previously documented HHP in hypertension prevalence extends to its management using clinical and self-reported measures from the 2007-2012 National Health and Nutrition Examination Surveys. Multivariate models adjusting for demographic, socioeconomic, and sociobehavioral characteristics show an advantage among foreign-born Mexicans in hypertension prevalence relative to non-Hispanic whites (adjusted OR = 0...
2017: Biodemography and Social Biology
https://www.readbyqxmd.com/read/29035105/racial-ethnic-differences-in-early-life-mortality-in-the-united-states
#9
Richard G Rogers, Elizabeth M Lawrence, Robert A Hummer, Andrea M Tilstra
U.S. early-life (ages 1-24) deaths are tragic, far too common, and largely preventable. Yet demographers have focused scant attention on U.S. early-life mortality patterns, particularly as they vary across racial and ethnic groups. We employed the restricted-use 1999-2011 National Health Interview Survey-Linked Mortality Files and hazard models to examine racial/ethnic differences in early-life mortality. Our results reveal that these disparities are large, strongly related to differences in parental socioeconomic status, and expressed through different causes of death...
2017: Biodemography and Social Biology
https://www.readbyqxmd.com/read/29035076/internal-and-external-sources-of-variability-in-perceptual-decision-making
#10
Roger Ratcliff, Chelsea Voskuilen, Gail McKoon
It is important to identify sources of variability in processing to understand decision-making in perception and cognition. There is a distinction between internal and external variability in processing, and double-pass experiments have been used to estimate their relative contributions. In these and our experiments, exact perceptual stimuli are repeated later in testing, and agreement on the 2 trials is examined to see if it is greater than chance. In recent research in modeling decision processes, some models implement only (internal) variability in the decision process whereas others explicitly represent multiple sources of variability...
October 16, 2017: Psychological Review
https://www.readbyqxmd.com/read/29034479/scaling-of-the-ankle-extensor-muscle-tendon-units-and-the-biomechanical-implications-for-bipedal-hopping-locomotion-in-the-post-pouch-kangaroo-macropus-fuliginosus
#11
Edward P Snelling, Andrew A Biewener, Qiaohui Hu, David A Taggart, Andrea Fuller, Duncan Mitchell, Shane K Maloney, Roger S Seymour
Bipedal hopping is used by macropods, including rat-kangaroos, wallabies and kangaroos (superfamily Macropodoidea). Interspecific scaling of the ankle extensor muscle-tendon units in the lower hindlimbs of these hopping bipeds shows that peak tendon stress increases disproportionately with body size. Consequently, large kangaroos store and recover more strain energy in their tendons, making hopping more efficient, but their tendons are at greater risk of rupture. This is the first intraspecific scaling analysis on the functional morphology of the ankle extensor muscle-tendon units (gastrocnemius, plantaris and flexor digitorum longus) in one of the largest extant species of hopping mammal, the western grey kangaroo Macropus fuliginosus (5...
October 16, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29034171/does-exposure-to-new-transport-infrastructure-result-in-modal-shifts-patterns-of-change-in-commute-mode-choices-in-a-four-year-quasi-experimental-cohort-study
#12
Eva Heinen, Amelia Harshfield, Jenna Panter, Roger Mackett, David Ogilvie
BACKGROUND: Intervention studies suggest that changing the built environment may encourage a modal shift from car travel towards active travel. However, little is known about the detail of patterns of changes in travel behaviour. METHOD: Adult commuters working in Cambridge (UK) completed annual questionnaires between 2009 and 2012. Commuting was assessed using a validated seven-day travel-to-work record. The intervention consisted of the opening of a guided busway with a path for walking and cycling in 2011...
September 2017: Journal of Transport & Health
https://www.readbyqxmd.com/read/29033812/the-successful-use-of-a-novel-microwave-device-in-the-treatment-of-a-plantar-wart
#13
Ivan Robert Bristow, Christopher Webb, Michael Roger Ardern-Jones
Plantar warts, caused by the human papilloma virus (HPV), are a commonly encountered condition presenting in clinic. In adults, an array of various therapies exists, frequently with modest results particularly with plantar lesions. Microwaves have had limited uses for medical purposes. Recently a new portable microwave device has been approved for the treatment of skin lesions. Prior research has demonstrated immuno-stimulatory effects against HPV infection. We report the application of a novel portable medical microwave unit to treat a long-standing plantar wart which had failed to respond to other treatment modalities...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29033781/direct-neuronal-reprogramming-for-disease-modeling-studies-using-patient-derived-neurons-what-have-we-learned
#14
REVIEW
Janelle Drouin-Ouellet, Karolina Pircs, Roger A Barker, Johan Jakobsson, Malin Parmar
Direct neuronal reprogramming, by which a neuron is formed via direct conversion from a somatic cell without going through a pluripotent intermediate stage, allows for the possibility of generating patient-derived neurons. A unique feature of these so-called induced neurons (iNs) is the potential to maintain aging and epigenetic signatures of the donor, which is critical given that many diseases of the CNS are age related. Here, we review the published literature on the work that has been undertaken using iNs to model human brain disorders...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29033551/healthcare-provider-relational-quality-is-associated-with-better-self-management-and-less-treatment-burden-in-people-with-multiple-chronic-conditions
#15
David T Eton, Jennifer L Ridgeway, Mark Linzer, Deborah H Boehm, Elizabeth A Rogers, Kathleen J Yost, Lila J Finney Rutten, Jennifer L Sauver, Sara Poplau, Roger T Anderson
PURPOSE: Having multiple chronic conditions (MCCs) can lead to appreciable treatment and self-management burden. Healthcare provider relational quality (HPRQ) - the communicative and interpersonal skill of the provider - may mitigate treatment burden and promote self-management. The objectives of this study were to 1) identify the associations between HPRQ, treatment burden, and psychosocial outcomes in adults with MCCs, and 2) determine if certain indicators of HPRQ are more strongly associated than others with these outcomes...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29032761/investigation-on-the-effects-of-antimicrobial-imidazo-2-1-b-thiazole-derivatives-on-the-genitourinary-microflora
#16
Rita Morigi, Beatrice Vitali, Cecilia Prata, Rogers A A Palomino, Alessandra Graziadio, Alessandra Locatelli, Mirella Rambaldi, Alberto Leoni
BACKGROUND: Fused five-membered heterocyclic rings containing bridgehead nitrogen atom are particularly versatile in the field of medicinal chemistry because of their different biological activities. Among them, the imidazo[2,1-b]thiazole is an attractive fused heterocyclic core that has been extensively studied. OBJECTIVE: The aim of the current study was to study the therapeutic applications of imidazo[2,1-b]thiazole derivatives as antimicrobial agents for the treatment of genitourinary infections...
October 10, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/29032464/nutritional-composition-of-honey-bee-food-stores-vary-with-floral-composition
#17
Philip Donkersley, Glenn Rhodes, Roger W Pickup, Kevin C Jones, Eileen F Power, Geraldine A Wright, Kenneth Wilson
Sufficiently diverse and abundant resources are essential for generalist consumers, and form an important part of a suite of conservation strategies for pollinators. Honey bees are generalist foragers and are dependent on diverse forage to adequately meet their nutritional needs. Through analysis of stored pollen (bee bread) samples obtained from 26 honey bee (Apis mellifera L.) hives across NW-England, we quantified bee bread nutritional content and the plant species that produced these stores from pollen...
October 14, 2017: Oecologia
https://www.readbyqxmd.com/read/29032235/variation-in-radiologic-and-urologic-computed-tomography-interpretation-of-urinary-tract-stone-burden-results-from-resku
#18
David T Tzou, Dylan Isaacson, Manint Usawachintachit, Zhen J Wang, Kazumi Taguchi, Nancy K Hills, Ryan S Hsi, Benjamin A Sherer, Shalonda Reliford-Titus, Brian Duty, Jonathan Harper, Mathew Sorensen, Roger L Sur, Marshall L Stoller, Thomas Chi
OBJECTIVE: To compare the measured stone burden recorded between urologists and radiologists, and examine how these differences could potentially impact stone management. As current urologic stone surgery guideline recommendations are based on stone size, accurate stone measurements are crucial to direct appropriate treatment. This study investigated the discrepant interpretation that often exists between urologic surgeons and radiologists' estimation of patient urinary stone burden. MATERIALS AND METHODS: From November 2015 through August 2016, new patients prospectively enrolled into the Registry for Stones of the Kidney and Ureter (ReSKU™) were included if they had computed tomography images available and an accompanying official radiologic report at the time of their urologist provider visit...
October 12, 2017: Urology
https://www.readbyqxmd.com/read/29032206/divalent-copper-complexes-as-influenza-a-m2-inhibitors
#19
Nathan A Gordon, Kelly L McGuire, Spencer K Wallentine, Gregory A Mohl, Jonathan D Lynch, Roger G Harrison, David D Busath
New M2 blockers effective against the ubiquitous amantadine-resistant S31N M2 mutation in influenza A are needed. Six copper complexes, 2, 4, 6, 8, 9, and 10, were synthesized and found to block both wild type and S31N M2. Free Cu(2+) also blocks M2 S31N but not S31N/H37A. The copper complexes do not block M2 H37A (either S31 or S31N). The complexes were effective against three influenza A strains in cell-culture assays, but less toxic to cells than CuCl2. For example 4, Cu(cyclooctylamineiminodiacetate), which was stable at pH > 4 in the buffers used, had an EC50 against A/Calif/07/2009 H1N1 of 0...
October 11, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29032111/paranormal-belief-and-errors-of-probabilistic-reasoning-the-role-of-constituent-conditional-relatedness-in-believers-susceptibility-to-the-conjunction-fallacy
#20
Paul Rogers, John E Fisk, Emma Lowrie
The present study examines the extent to which stronger belief in either extrasensory perception, psychokinesis or life-after-death is associated with a proneness to making conjunction errors (CEs). One hundred and sixty members of the UK public read eight hypothetical scenarios and for each estimated the likelihood that two constituent events alone plus their conjunction would occur. The impact of paranormal belief plus constituents' conditional relatedness type, estimates of the subjectively less likely and more likely constituents plus relevant interaction terms tested via three Generalized Linear Mixed Models...
October 12, 2017: Consciousness and Cognition
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