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https://www.readbyqxmd.com/read/29908366/g-d3-ganglioside-enriched-extracellular-vesicles-stimulate-melanocyte-migration
#1
Andreia Hanada Otake, Renata de Freitas Saito, Ana Paula Marques Duarte, Alexandre Ferreira Ramos, Roger Chammas
Melanomas often accumulate gangliosides, sialic acid-containing glycosphingolipids found in the outer leaflet of plasma membranes, as disialoganglioside GD3 and its derivatives. Here, we have transfected the GD3 synthase gene (ST8Sia I) in a normal melanocyte cell line in order to evaluate changes in the biological behavior of non-transformed cells. GD3 -synthase expressing cells converted GM3 into GD3 and accumulated both GD3 and its acetylated form, 9-O-acetyl-GD3 . Melanocytes were rendered more migratory on laminin-1 surfaces...
June 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29908046/sepsis-induced-acute-kidney-injury-a-disease-of-the-microcirculation
#2
Shuai Ma, Roger G Evans, Naoya Iguchi, Marianne Tare, Helena C Parkington, Rinaldo Bellomo, Clive N May, Yugeesh R Lankadeva
Acute kidney injury (AKI) is a common complication of sepsis and is significantly associated with mortality. Sepsis accounts for more than 50% of the cases of AKI, with a mortality rate of up to 40%. The pathogenesis of septic AKI is complex, but there is emerging evidence that, at least in the first 48 hours, the defects may be functional rather than structural in nature. For example, septic AKI is associated with an absence of histopathological changes, but with microvascular abnormalities and tubular stress...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29907924/heat-acclimation-increases-inflammatory-and-apoptotic-responses-to-subsequent-lps-challenge-in-c2c12-myotubes
#3
Meghan G Patton, Trevor L Gillum, Mandy C Szymanski, Lacey M Gould, Claire J Lauterbach, Roger A Vaughan, Matthew R Kuennen
This work investigated the ability of a 6-day heat acclimation protocol to impart heat acclimation-mediated cross-tolerance (HACT) in C2C12 myotubes, as indicated by changes in inflammatory and apoptotic responses to subsequent lipopolysaccharide (LPS) challenge. Myotubes were incubated at 40 °C for 2 h/day over 6 days (HA) or maintained for 6 days at 37 °C (C). Following 24 h recovery, myotubes from each group received either no stimulation or 500 ng/ml LPS for 2 h (HA + LPS and C + LPS, respectively)...
June 16, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29907345/situational-fears-association-with-negative-affect-related-smoking-cognition-among-treatment-seeking-smokers
#4
Jafar Bakhshaie, Andrew H Rogers, Brooke Y Kauffman, Melissa Fasteau, Julia D Buckner, Norman B Schmidt, Michael J Zvolensky
Despite the consistent clinically-significant relation between smoking and anxiety and its disorders, there is limited understanding of how specific fears relate to smoking processes. To isolate therapeutic targets for smoking-anxiety treatment development, there is a need to identify the underlying situational fears most related to smoking processes. Thus, the present study examined the association between interoceptive, agoraphobic, and social fears in terms of clinically significant negative affect-related smoking cognitions including negative affect reduction expectancies, coping motives, and perceived internal barriers to cessation...
June 9, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29907106/activation-and-polarization-of-circulating-monocytes-in-severe-chronic-obstructive-pulmonary-disease
#5
William D Cornwell, Victor Kim, Xiaoxuan Fan, Marie Elena Vega, Frederick V Ramsey, Gerard J Criner, Thomas J Rogers
BACKGROUND: The ability of circulating monocytes to develop into lung macrophages and promote lung tissue damage depends upon their phenotypic pattern of differentiation and activation. Whether this phenotypic pattern varies with COPD severity is unknown. Here we characterize the activation and differentiation status of circulating monocytes in patients with moderate vs. severe COPD. METHODS: Blood monocytes were isolated from normal non-smokers (14), current smokers (13), patients with moderate (9), and severe COPD (11)...
June 15, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29906718/review-adjunctive-pharmacologic-approaches-for-benzodiazepine-tapers
#6
REVIEW
Justine W Welsh, Valeria Tretyak, R Kathryn McHugh, Roger D Weiss, Olivera Bogunovic
BACKGROUND: Many patients require discontinuation of benzodiazepines due to a reduction in drug efficacy over time, the development of a sedative use disorder, or unwanted side effects. Benzodiazepine discontinuation can pose a significant challenge for prescribing clinicians due to potential withdrawal symptoms and a recurrence of psychiatric complaints. METHODS: A PubMed literature search was conducted using the medical subject heading of benzodiazepines in combination with the following key words: discontinuation, withdrawal, detoxification, cessation, dependence, addiction, substance use disorders, or long term...
May 31, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29906608/evolutionary-relationships-and-climatic-niche-evolution-in-the-genus-handleyomys-sigmodontinae-oryzomyini
#7
REVIEW
Ana Laura Almendra, Francisco X González-Cózatl, Mark D Engstrom, Duke S Rogers
Mesoamerica is considered a biodiversity hot spot with levels of endemism and species diversity likely underestimated. Unfortunately, the region continues to experience some of the highest deforestation rates in the world. For mammals, the evolutionary relationships of many endemic taxa are controversial, as it is the case for members of the genus Handleyomys. Estimation of a time-calibrated hypothesis for the evolution of these six genera (Euryoryzomys, Handleyomys, Hylaeamys, Nephelomys, Oecomys and Transandinomys) supported a monophyletic Handleyomys sensu lato...
June 12, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29906476/adar1-affects-hcv-infection-by-modulating-innate-immune-response
#8
Maria Pujantell, Sandra Franco, Iván Galván-Femenía, Roger Badia, Marc Castellví, Edurne Garcia-Vidal, Bonaventura Clotet, Rafael de Cid, Cristina Tural, Miguel A Martínez, Eva Riveira-Muñoz, José A Esté, Ester Ballana
The hepatitis C virus (HCV) is a globally prevalent infectious pathogen. As many as 80% of people infected with HCV do not control the virus and develop a chronic infection. Response to interferon (IFN) therapy is widely variable in chronic HCV infected patients, suggesting that HCV has evolved mechanisms to suppress and evade innate immunity responsible for its control and elimination. Adenosine deaminase acting on RNA 1 (ADAR1) is a relevant factor in the regulation of the innate immune response. The loss of ADAR1 RNA-editing activity and the resulting loss of inosine bases in RNA are critical in producing aberrant RLR-mediated innate immune response, mediated by RNA sensors MDA5 and RIG-I...
June 12, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29906466/tarps-differentially-affect-the-pharmacology-of-ampakines
#9
Daniel P Radin, Yong-Xin Li, Gary Rogers, Richard Purcell, Arnold Lippa
Transmembrane AMPA receptor regulatory proteins (TARPs) govern AMPA receptor cell surface expression and distinct physiological properties including agonist affinity, desensitization and deactivation kinetics. The prototypical TARP, STG or γ2 and TARPs γ3, γ4, γ7 and γ8 are all expressed to varying degrees in the mammalian brain and differentially regulate AMPAR gating parameters. Positive allosteric AMPA receptor modulators or ampakines alter receptor rates of agonist binding/unbinding, channel opening and can offset receptor desensitization and deactivation...
June 12, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29905884/proximal-and-distal-effects-of-sensation-seeking-and-parenting-environments-on-alcohol-use-trajectories-from-early-adolescence-to-early-adulthood
#10
Adam A Rogers, Kit K Elam, Laurie Chassin, Ariel Sternberg, Leena Bui
Adolescent alcohol use is related to disinhibition traits and family environments. However, research is scarce on whether these factors predict alcohol use trajectories distally, from early adolescence into early adulthood. We examined whether sensation seeking and parenting environments in early adolescence predicted adolescents' alcohol use trajectories proximally (middle-adolescence) and distally (early adulthood). Using four waves of data from 345 adolescents (51.3% female; 80% white) and their primary caregivers, we estimated adolescents' alcohol use trajectories and examined variability in these by sensation seeking and parental control...
June 15, 2018: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29905769/serologic-follow-up-of-middle-east-respiratory-syndrome-coronavirus-cases-and-contacts-abu-dhabi-united-arab-emirates
#11
Farida Ismail Al Hosani, Lindsay Kim, Ahmed Khudhair, Huong Pham, Mariam Al Mulla, Zyad Al Bandar, Krishna Pradeep, Kheir Abou Elkheir, Stefan Weber, Mary Khoury, George Donnelly, Naima Younis, Feda El Saleh, Muna Abdalla, Hala Imambaccus, Lia M Haynes, Natalie J Thornburg, Jennifer L Harcourt, Congrong Miao, Azaibi Tamin, Aron J Hall, Elizabeth S Russell, Aaron M Harris, Craig Kiebler, Roger A Mir, Kimberly Pringle, Negar N Alami, Glen R Abedi, Susan I Gerber
Background: Although there is evidence of person-to-person transmission of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in household and healthcare settings, more data are needed to describe and better understand the risk factors and transmission routes in both settings, as well as the extent that disease severity affects transmission. Methods: A sero-epidemiological investigation was conducted among Middle East Respiratory Syndrome Coronavirus (MERS-CoV) case-patients and their household contacts to investigate transmission risk in Abu Dhabi, United Arab Emirates...
June 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29905470/ultrasensitive-plasmonic-biosensors-for-real-time-parallel-detection-of-alpha-l-fucosidase-and-cardiac-troponin-i-in-whole-human-blood
#12
Xu Han, Hossein Shokri Kojori, Roger M Leblanc, Sung Jin Kim
Cancers and many other diseases, such as hepatocellular carcinoma (HCC) and cardiovascular diseases (CVD), have threatened human lives for centuries. Therefore, a novel technique for such disease prediction, therefore, is in an urgent demand for timely treatment. Biomarkers - alpha-L-fucosidase (AFU) for HCC and cardiac troponin I (cTnI) for CVD - have proven to be essential in the role of disease detection. Herein, we report on an ultrasensitive plasmonic biosensor that converts plasmonic absorption to electrical current in order to detect AFU and cTnI using whole human blood in a real-time and parallel fashion...
June 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29904176/cancer-prevention-by-aspirin-in-children-with-constitutional-mismatch-repair-deficiency-cmmrd
#13
REVIEW
Erika K S M Leenders, Harm Westdorp, Roger J Brüggemann, Jan Loeffen, Christian Kratz, John Burn, Nicoline Hoogerbrugge, Marjolijn C J Jongmans
Constitutional MisMatch Repair Deficiency (CMMRD) is caused by homozygous or compound heterozygous germline variants in one of the mismatch repair (MMR) genes (MSH2, MSH6, PMS2, MLH1). This syndrome results in early onset colorectal cancer, leukemia and lymphoma, brain tumors and other malignancies. Children with CMMRD are at high risk of developing multiple cancers and cancer surveillance does not guarantee detection of cancer at a curable stage. The development of a preventive treatment strategy would be a major step forward...
June 14, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29903854/development-of-a-consensus-approach-for-return-of-pathology-incidental-findings-in-the-genotype-tissue-expression-gtex-project
#14
Nicole C Lockhart, Carol J Weil, Latarsha J Carithers, Susan E Koester, A Roger Little, Simona Volpi, Helen M Moore, Benjamin E Berkman
The active debate about the return of incidental or secondary findings in research has primarily focused on return to research participants, or in some cases, family members. Particular attention has been paid to return of genomic findings. Yet, research may generate other types of findings that warrant consideration for return, including findings related to the pathology of donated biospecimens. In the case of deceased biospecimen donors who are also organ and/or tissue transplant donors, pathology incidental findings may be relevant not to family members, but to potential organ or tissue transplant recipients...
June 14, 2018: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29903623/immune-checkpoint-mediated-myositis-and-myasthenia-gravis-a-case-report-and-review-of-evaluation-and-management
#15
Kylie H Kang, William Grubb, Komal Sawlani, Michael K Gibson, Christopher J Hoimes, Lisa R Rogers, Pierre Lavertu, Min Yao
BACKGROUND: We present a case of myositis and possible overlapping neuromuscular junction disorder following treatment with nivolumab for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). METHODS: We report a 75-year-old man with recurrent stage IVA, T1N2cM0 oral cavity HNSCC treated with weight-dosed nivolumab who presented three weeks later with severe fatigue, generalized weakness, and bilateral ptosis. Evaluation demonstrated elevated creatine kinase and myopathic motor units on electromyography, supporting a diagnosis of an underlying muscle disease...
June 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29902576/lymphomas-with-pseudo-double-hit-bcl6-myc-translocations-due-to-t-3-8-q27-q24-are-associated-with-a-germinal-center-immunophenotype-extranodal-involvement-and-frequent-bcl2-translocations
#16
Steven M Johnson, Jayadev Manikkam Umakanthan, Ji Yuan, Yuri Fedoriw, R Gregory Bociek, Kathleen Kaiser-Rogers, Jennifer N Sanmann, Nathan D Montgomery
High-grade B-cell lymphomas with MYC, BCL2, and/or BCL6 rearrangements, "double hit" or "triple hit" lymphomas (DTHL), are aggressive neoplasms associated with a poor prognosis. A t(3;8)(q27;q24) rarely occurs in B-cell lymphomas that results in a unique "pseudo-double hit" BCL6-MYC fusion, indistinguishable by interphase fluorescence in situ hybridization (FISH) from more conventional DTHL with independent MYC and BCL6 translocations. Reports of t(3;8)(q27;q24) lymphomas are sparse, and to better characterize their pathologic, cytogenetic, and clinical features, 6 new cases from 2 institutions and 19 previously published cases were reviewed...
June 11, 2018: Human Pathology
https://www.readbyqxmd.com/read/29902446/a-conceptual-framework-for-the-impact-of-obesity-on-risk-of-cesarean-delivery
#17
Anna Joy G Rogers, Lorie M Harper, Giancarlo Mari
Cesarean deliveries accounted for 32.2% of nearly 4 million births in the United States in 2014. Obesity affects a third of reproductive age women and is associated with worse cesarean delivery outcomes. Studies have shown that increasing maternal body mass index correlates linearly with cesarean delivery rates, but little is known about the potential mediating and moderating mechanisms. Thus, a conceptual framework for understanding how obesity correlates with risk of cesarean delivery is crucial to determining safe ways to reduce the cesarean delivery rate among obese gravidas...
June 11, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29902235/elevated-co2-mitigates-the-effect-of-surface-drought-by-stimulating-root-growth-to-access-sub-soil-water
#18
Shihab Uddin, Markus Löw, Shahnaj Parvin, Glenn J Fitzgerald, Sabine Tausz-Posch, Roger Armstrong, Garry O'Leary, Michael Tausz
Through stimulation of root growth, increasing atmospheric CO2 concentration ([CO2]) may facilitate access of crops to sub-soil water, which could potentially prolong physiological activity in dryland environments, particularly because crops are more water use efficient under elevated [CO2] (e[CO2]). This study investigated the effect of drought in shallow soil versus sub-soil on agronomic and physiological responses of wheat to e[CO2] in a glasshouse experiment. Wheat (Triticum aestivum L. cv. Yitpi) was grown in split-columns with the top (0-30 cm) and bottom (31-60 cm; 'sub-soil') soil layer hydraulically separated by a wax-coated, root-penetrable layer under ambient [CO2] (a[CO2], ∼400 μmol mol-1) or e[CO2] (∼700 μmol mol-1) [CO2]...
2018: PloS One
https://www.readbyqxmd.com/read/29902157/therapeutic-potential-of-jak-stat-pathway-modulation-in-mood-disorders
#19
Aisha S Shariq, Elisa Brietzke, Joshua D Rosenblat, Zihang Pan, Carola Rong, Renee-Marie Ragguett, Caroline Park, Roger S McIntyre
Convergent evidence demonstrates that immune dysfunction (e.g. chronic low-grade inflammatory activation) plays an important role in the development and progression of mood disorders. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is a pleiotropic cellular cascade that transduces numerous signals, including signals from the release of cytokines and growth factors. The JAK/STAT signaling pathway is involved in mediating several functions of the central nervous system, including neurogenesis, synaptic plasticity, gliogenesis, and microglial activation, all of which have been implicated in the pathophysiology of mood disorders...
June 14, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29902056/age-related-differences-in-mind-wandering-in-daily-life
#20
David Maillet, Roger E Beaty, Megan L Jordano, Dayna R Touron, Areeba Adnan, Paul J Silvia, Thomas R Kwapil, Gary R Turner, R Nathan Spreng, Michael J Kane
In recent years, several laboratory studies have indicated that healthy older adults exhibit a reduction in mind-wandering frequency compared with young adults. However, it is unclear if these findings extend to daily life settings. In the current study, using experience sampling over the course of a week in the daily life of 31 young and 20 older adults, we assessed age-related differences in: (a) mind-wandering frequency, (b) the relationship between affect and mind-wandering frequency, and (c) content of mind wandering...
June 2018: Psychology and Aging
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