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https://www.readbyqxmd.com/read/29656237/vascularized-microfluidic-organ-chips-for-drug-screening-disease-models-and-tissue-engineering
#1
REVIEW
Tatsuya Osaki, Vivek Sivathanu, Roger D Kamm
Vascularization of micro-tissues in vitro has enabled formation of tissues larger than those limited by diffusion with appropriate nutrient/gas exchange as well as waste elimination. Furthermore, angiocrine signaling from the vasculature may be essential in mimicking organ-level functions in these micro-tissues. In drug screening applications, the presence of an appropriate blood-organ barrier in the form of a vasculature and its supporting cells (pericytes, appropriate stromal cells) may be essential to reproducing organ-scale drug delivery pharmacokinetics...
April 12, 2018: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29655973/robust-workflow-and-instrumentation-for-cryo-focused-ion-beam-milling-of-samples-for-electron-cryotomography
#2
João M Medeiros, Désirée Böck, Gregor L Weiss, Romain Kooger, Roger A Wepf, Martin Pilhofer
Electron cryotomography is able to visualize macromolecular complexes in their cellular context, in a frozen-hydrated state, and in three dimensions. The method, however, is limited to relatively thin samples. Cryo-focused ion beam (FIB) milling is emerging as a powerful technique for sample thinning prior to cryotomography imaging. Previous cryo-FIB milling reports utilized custom-built non-standard equipment. Here we present a workflow and the required commercially available instrumentation to either implement the method de novo, or as an upgrade of pre-existing dual beam milling instruments...
April 6, 2018: Ultramicroscopy
https://www.readbyqxmd.com/read/29655754/green-and-fast-determination-of-the-alcoholic-content-of-wines-using-thermal-infrared-enthalpimetry
#3
Alessandra S Oliveira, Cristiano A Ballus, Cristiano R Menezes, Roger Wagner, José Neri G Paniz, Bruna Tischer, Adilson B Costa, Juliano S Barin
An innovative use of thermal infrared enthalpimetry (TIE) is proposed for the determination of alcoholic content of red and white wines. Notwithstanding the presence of ethanol in beverages, absolute ethanol was added directly to wines, and the temperature rise caused by the heat of dilution was monitored using an infrared camera. Analytical signals were obtained in only 10 s for four samples simultaneously, and a calibration curve was constructed with hydroalcoholic reference solutions. A linear calibration curve was obtained from 3...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29655580/canadian-association-of-radiologists-white-paper-on-artificial-intelligence-in-radiology
#4
REVIEW
An Tang, Roger Tam, Alexandre Cadrin-Chênevert, Will Guest, Jaron Chong, Joseph Barfett, Leonid Chepelev, Robyn Cairns, J Ross Mitchell, Mark D Cicero, Manuel Gaudreau Poudrette, Jacob L Jaremko, Caroline Reinhold, Benoit Gallix, Bruce Gray, Raym Geis
Artificial intelligence (AI) is rapidly moving from an experimental phase to an implementation phase in many fields, including medicine. The combination of improved availability of large datasets, increasing computing power, and advances in learning algorithms has created major performance breakthroughs in the development of AI applications. In the last 5 years, AI techniques known as deep learning have delivered rapidly improving performance in image recognition, caption generation, and speech recognition...
April 11, 2018: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/29653348/increased-oxidative-stress-in-the-mitochondria-isolated-from-lymphocytes-of-bipolar-disorder-patients-during-depressive-episodes
#5
Samira S Valvassori, Daniela V Bavaresco, Gustavo Feier, Kelen Cechinel-Recco, Amanda V Steckert, Roger B Varela, Cenita Borges, Milena Carvalho-Silva, Lara M Gomes, Emílio L Streck, João Quevedo
The present study aims to investigate the oxidative stress parameters in isolated mitochondria, as well as looking at mitochondrial complex activity in patients with Bipolar Disorder (BD) during depressive or euthymic episodes. This study evaluated the levels of mitochondrial complex (I, II, II-III and IV) activity in lymphocytes from BD patients. We evaluated the following oxidative stress parameters: superoxide, thiobarbituric acid reactive species (TBARS) and carbonyl levels in submitochondrial particles of lymphocytes from bipolar patients...
April 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29653088/nodal-and-bmp-dispersal-during-early-zebrafish-development
#6
REVIEW
Katherine W Rogers, Patrick Müller
The secreted TGF-β superfamily signals Nodal and BMP coordinate the patterning of vertebrate embryos. Nodal specifies endoderm and mesoderm during germ layer formation, and BMP specifies ventral fates and patterns the dorsal/ventral axis. Five major models have been proposed to explain how the correct distributions of Nodal and BMP are achieved within tissues to orchestrate embryogenesis: source/sink, transcriptional determination, relay, self-regulation, and shuttling. Here, we discuss recent experiments probing these signal dispersal models, focusing on early zebrafish development...
April 10, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29652794/the-voice-of-the-heart-vowel-like-sound-in-pulmonary-artery-hypertension
#7
Mohamed Elgendi, Prashant Bobhate, Shreepal Jain, Long Guo, Jennifer Rutledge, Yashu Coe, Roger Zemp, Dale Schuurmans, Ian Adatia
Increased blood pressure in the pulmonary artery is referred to as pulmonary hypertension and often is linked to loud pulmonic valve closures. For the purpose of this paper, it was hypothesized that pulmonary circulation vibrations will create sounds similar to sounds created by vocal cords during speech and that subjects with pulmonary artery hypertension (PAH) could have unique sound signatures across four auscultatory sites. Using a digital stethoscope, heart sounds were recorded at the cardiac apex, 2nd left intercostal space (2LICS), 2nd right intercostal space (2RICS), and 4th left intercostal space (4LICS) undergoing simultaneous cardiac catheterization...
April 13, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29652739/commentary-roger-baxter
#8
Steven Black
No abstract text is available yet for this article.
May 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29652345/impact-of-mechanical-stress-induced-in-silica-vacuum-windows-on-laser-induced-damage
#9
Clémence Gingreau, Thomas Lanternier, Laurent Lamaignère, Thierry Donval, Roger Courchinoux, Christophe Leymarie, Jérôme Néauport
At the interface between vacuum and air, optical windows must keep their optical properties, despite being subjected to mechanical stress. In this Letter, we investigate the impact of such stress on the laser-induced damage of fused silica windows at the wavelength of 351 nm in the nanosecond regime. Different stress values, from 1 to 30 MPa, both tensile and compressive, were applied. No effect of the stress on the laser-induced damage was evidenced.
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29651460/isoprene-photo-oxidation-products-quantify-the-effect-of-pollution-on-hydroxyl-radicals-over-amazonia
#10
Yingjun Liu, Roger Seco, Saewung Kim, Alex B Guenther, Allen H Goldstein, Frank N Keutsch, Stephen R Springston, Thomas B Watson, Paulo Artaxo, Rodrigo A F Souza, Karena A McKinney, Scot T Martin
Nitrogen oxides (NO x ) emitted from human activities are believed to regulate the atmospheric oxidation capacity of the troposphere. However, observational evidence is limited for the low-to-median NO x concentrations prevalent outside of polluted regions. Directly measuring oxidation capacity, represented primarily by hydroxyl radicals (OH), is challenging, and the span in NO x concentrations at a single observation site is often not wide. Concentrations of isoprene and its photo-oxidation products were used to infer the equivalent noontime OH concentrations...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29650957/two-dimensional-materials-in-functional-three-dimensional-architectures-with-applications-in-photodetection-and-imaging
#11
Wonho Lee, Yuan Liu, Yongjun Lee, Bhupendra K Sharma, Sachin M Shinde, Seong Dae Kim, Kewang Nan, Zheng Yan, Mengdi Han, Yonggang Huang, Yihui Zhang, Jong-Hyun Ahn, John A Rogers
Efficient and highly functional three-dimensional systems that are ubiquitous in biology suggest that similar design architectures could be useful in electronic and optoelectronic technologies, extending their levels of functionality beyond those achievable with traditional, planar two-dimensional platforms. Complex three-dimensional structures inspired by origami, kirigami have promise as routes for two-dimensional to three-dimensional transformation, but current examples lack the necessary combination of functional materials, mechanics designs, system-level architectures, and integration capabilities for practical devices with unique operational features...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29650595/arr%C3%A3%C2%AAtez-d%C3%A2-invoquer-les-donn%C3%A3-es-probantes
#12
EDITORIAL
Roger Ladouceur
No abstract text is available yet for this article.
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650594/stop-invoking-evidence-based-data
#13
EDITORIAL
Roger Ladouceur
No abstract text is available yet for this article.
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650553/enduring-epigenetic-landmarks-define-the-cancer-microenvironment
#14
Ruth Pidsley, Mitchell G Lawrence, Elena Zotenko, Birunthi Niranjan, Aaron Statham, Jenny Song, Roman M Chabanon, Wenjia Qu, Hong Wang, Michelle Richards, Shalima S Nair, Nicola J Armstrong, Hieu T Nim, Melissa Papargiris, Preetika Balanathan, Hugh French, Timothy Peters, Sam Norden, Andrew Ryan, John Pedersen, James Kench, Roger J Daly, Lisa G Horvath, Phillip Stricker, Mark Frydenberg, Renea A Taylor, Clare Stirzaker, Gail P Risbridger, Susan J Clark
The growth and progression of solid tumors involves dynamic cross-talk between cancer epithelium and the surrounding microenvironment. To date, molecular profiling has largely been restricted to the epithelial component of tumors; therefore, features underpinning the persistent protumorigenic phenotype of the tumor microenvironment are unknown. Using whole-genome bisulfite sequencing, we show for the first time that cancer-associated fibroblasts (CAFs) from localized prostate cancer display remarkably distinct and enduring genome-wide changes in DNA methylation, significantly at enhancers and promoters, compared to nonmalignant prostate fibroblasts (NPFs)...
April 12, 2018: Genome Research
https://www.readbyqxmd.com/read/29650397/assessment-of-five-different-probes-for-lung-ultrasound-in-critically-ill-patients-a-pilot-study
#15
Xavier Bobbia, Margaux Chabannon, Thierry Chevallier, Jean Emmanuel de La Coussaye, Jean Yves Lefrant, Sarah Pujol, Pierre-Géraud Claret, Laurent Zieleskiewicz, Claire Roger, Laurent Muller
INTRODUCTION: The present study was aimed at comparing the diagnosis concordance of five echo probes of lung ultrasound (LUS) with CT scans in intensive care and emergency patients with acute respiratory failure. MATERIALS: This prospective, observational, pilot study involved 10 acute patients in whom a thoracic CT scan was performed. An expert performed an LUS reference exam using five different probes: three probes with a high-quality conventional echo machine (cardiac phased-array probe, abdominal convex probe, linear probe) and two probes (cardiac and linear) with a pocket ultrasound device (PUD)...
April 3, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29650142/endoscopic-approaches-to-upper-tract-urothelial-carcinoma
#16
REVIEW
Firas G Petros, Roger Li, Surena F Matin
A select group of patients with upper tract urothelial carcinoma (UTUC) may meet indications for endoscopic management. Strategies for disease management are provided, based on a comprehensive review of the data using PubMed and Medline databases and marrying this with our experience with endoscopic management of UTUC. Endoscopic management of UTUC via retrograde or antegrade approaches is a viable treatment option for appropriately selected patients with low-risk UTUC, including those with low-grade, low-volume, and solitary tumors...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29650132/optimal-timing-of-chemotherapy-and-surgery-in-patients-with-muscle-invasive-bladder-cancer-and-upper-urinary-tract-urothelial-carcinoma
#17
REVIEW
William Tabayoyong, Roger Li, Jianjun Gao, Ashish Kamat
Radical cystectomy with bilateral pelvic lymph node dissection is the standard of care for patients with clinically localized muscle-invasive bladder cancer. Survival after radical cystectomy is associated with final pathologic staging. Survival decreases with increasing pT stage because of the presence of occult micrometastases, indicating the need for systemic chemotherapy. Systemic chemotherapy is delivered as either neoadjuvant therapy preoperatively, or as adjuvant therapy postoperatively. This article reviews the evidence for neoadjuvant and adjuvant chemotherapy for the treatment of muscle-invasive bladder and upper tract urothelial cancer and offers recommendations based on these data and recently updated clinical guidelines...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29649516/-mom-quit-fat-talking-i-m-trying-to-eat-mindfully-here-evaluating-a-sociocultural-model-of-family-fat-talk-positive-body-image-and-mindful-eating-in-college-women
#18
Jennifer B Webb, Courtney B Rogers, Lena Etzel, Meagan P Padro
A growing evidence base confirms sociocultural theory's predictions regarding the influence of direct exposure to family factors (e.g., parental commentary) in promoting disordered eating behavior as mediated by negative body image. Nevertheless, this model has not been specifically applied to investigating indirect or vicarious exposure to family communications (e.g., negative body talk) in estimating mindful eating behavior via positive body image intervening variables. Therefore, to address this gap the present study provided a preliminary evaluation of the indirect effects of overhearing family fat talk through both body appreciation and functional body appreciation in predicting mindful eating among undergraduate females...
April 9, 2018: Appetite
https://www.readbyqxmd.com/read/29649327/evaluation-of-intraoperative-touch-imprint-cytology-on-axillary-sentinel-lymph-nodes-in-invasive-breast-carcinomas-a-retrospective-study-of-1227-patients-comparing-sensitivity-in-the-different-tumor-subtypes
#19
Hafsteinn Ingi Pétursson, Anikó Kovács, Jan Mattsson, Roger Olofsson Bagge
BACKGROUND: Intraoperative evaluation of the axillary sentinel lymph node (SLN) in patients with breast carcinoma reduces the need of re-operations in cases where an axillary completion lymph node dissection (CLND) is indicated. Different methods have been used to determine the SLN status intraoperatively, e.g. frozen section histology (FS) and touch imprint cytology (TIC). The sensitivity of intraoperative TIC examination on SLN is not consistent between different studies and varies according to different tumor histologic subtypes, tumor size and the age of the patient...
2018: PloS One
https://www.readbyqxmd.com/read/29649261/delineation-and-mapping-of-coastal-shark-habitat-within-a-shallow-lagoonal-estuary
#20
Charles W Bangley, Lee Paramore, Simon Dedman, Roger A Rulifson
Estuaries function as important nursery and foraging habitats for many coastal species, including highly migratory sharks. Pamlico Sound, North Carolina, is one of the largest estuaries in the continental United States and provides a variety of potential habitats for sharks. In order to identify and spatially delineate shark habitats within Pamlico Sound, shark catch and environmental data were analyzed from the 2007-2014 North Carolina Division of Marine Fisheries (NCDMF) gillnet and longline surveys conducted within the estuary...
2018: PloS One
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