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https://www.readbyqxmd.com/read/29474698/antibodies-in-the-diagnosis-prognosis-and-prediction-of-psychotic-disorders
#1
Thomas A Pollak, Jonathan P Rogers, Robert G Nagele, Mark Peakman, James M Stone, Anthony S David, Philip McGuire
Blood-based biomarker discovery for psychotic disorders has yet to impact upon routine clinical practice. In physical disorders antibodies have established roles as diagnostic, prognostic and predictive (theranostic) biomarkers, particularly in disorders thought to have a substantial autoimmune or infective aetiology. Two approaches to antibody biomarker identification are distinguished: a "top-down" approach, in which antibodies to specific antigens are sought based on the known function of the antigen and its putative role in the disorder, and emerging "bottom-up" or "omics" approaches that are agnostic as to the significance of any one antigen, using high-throughput arrays to identify distinctive components of the antibody repertoire...
February 21, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29474648/an-integrated-quantitative-index-for-measuring-chronic-multisite-pain-the-multiple-areas-of-pain-map-study
#2
Mark S Wallace, James North, Eric J Grigsby, Leonardo Kapural, Mahendra R Sanapati, Stephen G Smith, Channing Willoughby, Patrick J McIntyre, Steven P Cohen, Richard M Rosenthal, Shaik Ahmed, Ricardo Vallejo, Farshad M Ahadian, Thomas L Yearwood, Allen W Burton, Edward J Frankoski, Jai Shetake, Sherry Lin, Brad Hershey, Benjamin Rogers, Nitzan Mekel-Bobrov
Objective: Despite the high prevalence of chronic multisite pain, there is little consensus on methods to characterize it. Commonly used assessments report only one dimension of pain, that is, intensity, thus ignoring the spatial aspect of pain. We developed a novel pain quantification index, the Integrated Pain Quantification Index (IPQI), on a scale of 0 to 1 that integrates multiple distinct pain measures into a single value, thus representing multidimensional pain information with a single value...
February 21, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29474456/correction-stage-specific-ifn-induced-and-ifn-gene-expression-reveal-convergence-of-type-i-and-type-ii-ifn-and-highlight-their-role-in-both-acute-and-chronic-stage-of-pathogenic-siv-infection
#3
Nadia Echebli, Nicolas Tchitchek, Stéphanie Dupuy, Timothée Bruel, Caroline Passaes, Nathalie Bosquet, Roger Le Grand, Christine Bourgeois, Benoit Favier, Rémi Cheynier, Olivier Lambotte, Bruno Vaslin
[This corrects the article DOI: 10.1371/journal.pone.0190334.].
2018: PloS One
https://www.readbyqxmd.com/read/29474410/factor-structure-and-measurement-invariance-across-various-demographic-groups-and-over-time-for-the-phq-9-in-primary-care-patients-in-spain
#4
César González-Blanch, Leonardo Adrián Medrano, Roger Muñoz-Navarro, Paloma Ruíz-Rodríguez, Juan Antonio Moriana, Joaquín T Limonero, Florian Schmitz, Antonio Cano-Vindel
The Patient Health Questionnaire (PHQ-9) is a widely-used screening tool for depression in primary care settings. The purpose of the present study is to identify the factor structure of the PHQ-9 and to examine the measurement invariance of this instrument across different sociodemographic groups and over time in a sample of primary care patients in Spain. Data came from 836 primary care patients enrolled in a randomized controlled trial (PsicAP study) and a subsample of 218 patients who participated in a follow-up assessment at 3 months...
2018: PloS One
https://www.readbyqxmd.com/read/29474224/the-nursing-knowledge-pyramid-a-theory-of-the-structure-of-nursing-knowledge
#5
Veronica B Decker, Roger M Hamilton
A theory of the structure of nursing knowledge is proposed. Using retroductive reasoning to build upon an existing theory, the goal of the Nursing Knowledge Pyramid is to integrate disparate forms of nursing knowledge into a comprehensive, coherent, and useful structure to enhance the learning, development, automation, and accessibility of nursing knowledge. Education uses are discussed.
February 22, 2018: ANS. Advances in Nursing Science
https://www.readbyqxmd.com/read/29473290/estimating-gestational-age-at-birth-from-fundal-height-and-additional-anthropometrics-a-prospective-cohort-study
#6
Sarah J Pugh, Ana M Ortega-Villa, William Grobman, Roger B Newman, John Owen, Deborah A Wing, Paul S Albert, Katherine L Grantz
OBJECTIVE: Accurate assessment of gestational age is critical to pediatric care, yet is limited in developing countries without access to ultrasound. Our objectives were to assess the accuracy of gestational age at birth (GA) prediction and preterm birth (PTB) classification using routinely collected anthropometry measures. DESIGN: Prospective cohort study. SETTING: United States. POPULATION OR SAMPLE: 2334 non-obese and 468 obese pregnant women...
February 23, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29473243/development-and-validation-of-an-algorithm-for-the-study-of-sleep-using-a-biometric-shirt-in-young-healthy-adults
#7
Joëlle Pion-Massicotte, Roger Godbout, Pierre Savard, Jean-François Roy
Portable polysomnography is often too complex and encumbering for recording sleep at home. We recorded sleep using a biometric shirt (electrocardiogram sensors, respiratory inductance plethysmography bands and an accelerometer) in 21 healthy young adults recorded in a sleep laboratory for two consecutive nights, together with standard polysomnography. Polysomnographic recordings were scored using standard methods. An algorithm was developed to classify the biometric shirt recordings into rapid eye movement sleep, non-rapid eye movement sleep and wake...
February 23, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29473145/considerations-for-developing-targeted-therapies-in-low-frequency-molecular-subsets-of-a-disease
#8
Robert N Schuck, Janet Woodcock, Issam Zineh, Peter Stein, Jonathan Jarow, Robert Temple, Thomas Permutt, Lisa LaVange, Julia A Beaver, Rosane Charlab, Gideon M Blumenthal, Sarah E Dorff, Christopher Leptak, Steven Lemery, Hobart Rogers, Badrul Chowdhury, E David Litwack, Michael Pacanowski
Advances in our understanding of the molecular underpinnings of disease have spurred the development of targeted therapies and the use of precision medicine approaches in patient care. While targeted therapies have improved our capability to provide effective treatments to patients, they also present additional challenges to drug development and benefit-risk assessment such as identifying the subset(s) of patients likely to respond to the drug, assessing heterogeneity in response across molecular subsets of a disease, and developing diagnostic tests to identify patients for treatment...
February 23, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29473111/correction-to-the-effect-of-cationically-modified-phosphorylcholine-polymers-on-human-osteoblasts-in-vitro-and-their-effect-on-bone-formation-in-vivo
#9
Jonathan M Lawton, Mariam Habib, Bingkui Ma, Roger A Brooks, Serena M Best, Andrew L Lewis, Neil Rushton, William Bonfield
The article "The effect of cationically modified phosphorylcholine polymers on human osteoblasts in vitro and their effect on bone formation in vivo", written by Jonathan M. Lawton, Mariam Habib, Bingkui Ma, Roger A. Brooks, Serena M. Best, Andrew L. Lewis, Neil Rushton and William Bonfield, was originally published Online First without open access. After publication in volume 28, issue 9, page 144 it was noticed that the copyright was wrong in the PDF version of the article. The copyright of the article should read as "...
February 22, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29472838/cancer-imprints-an-increased-parp-1-and-p53-dependent-resistance-to-oxidative-stress-on-lymphocytes-of-patients-that-later-develop-alzheimer-s-disease
#10
Felipe Salech, Daniela P Ponce, Carol D SanMartín, Nicole K Rogers, Mauricio Henríquez, Maria I Behrens
We have proposed that a common biological mechanism deregulated in opposite directions might explain the inverse epidemiological association observed between Alzheimer's disease (AD) and cancer. Accordingly, we showed that lymphocytes from AD patients have an increased susceptibility, whereas those from survivors of a skin cancer, an increased resistance to oxidative death induced by hydrogen peroxide (H2 O2 ), compared to healthy controls (HC). We investigated the susceptibility to H2 O2 -induced death of lymphocytes in survivors of any type of cancer and in cancer survivors who later developed AD (Ca&AD)...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29472568/lack-of-galectin-3-modifies-differentially-notch-ligands-in-bone-marrow-and-spleen-stromal-cells-interfering-with-b-cell-differentiation
#11
Felipe Leite de Oliveira, Sofia Nascimento Dos Santos, Lauremilia Ricon, Thayse Pinheiro da Costa, Jonathas Xavier Pereira, Camila Brand, Marise Lopes Fermino, Roger Chammas, Emerson Soares Bernardes, Márcia Cury El-Cheikh
Galectin-3 (Gal-3) is a β-galactoside binding protein that controls cell-cell and cell-extracellular matrix interactions. In lymphoid organs, gal-3 inhibits B cell differentiation by mechanisms poorly understood. The B cell development is dependent on tissue organization and stromal cell signaling, including IL-7 and Notch pathways. Here, we investigate possible mechanisms that gal-3 interferes during B lymphocyte differentiation in the bone marrow (BM) and spleen. The BM of gal-3-deficient mice (Lgals3-/- mice) was evidenced by elevated numbers of B220+ CD19+ c-Kit+ IL-7R+ progenitor B cells...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29472455/bak-bax-macropores-facilitate-mitochondrial-herniation-and-mtdna-efflux-during-apoptosis
#12
Kate McArthur, Lachlan W Whitehead, John M Heddleston, Lucy Li, Benjamin S Padman, Viola Oorschot, Niall D Geoghegan, Stephane Chappaz, Sophia Davidson, Hui San Chin, Rachael M Lane, Marija Dramicanin, Tahnee L Saunders, Canny Sugiana, Romina Lessene, Laura D Osellame, Teng-Leong Chew, Grant Dewson, Michael Lazarou, Georg Ramm, Guillaume Lessene, Michael T Ryan, Kelly L Rogers, Mark F van Delft, Benjamin T Kile
Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that induce mitochondrial outer membrane permeabilization, leading to cytochrome c release and activation of apoptotic caspases. In the absence of active caspases, mitochondrial DNA (mtDNA) triggers the innate immune cGAS/STING pathway, causing dying cells to secrete type I interferon. How cGAS gains access to mtDNA remains unclear. We used live-cell lattice light-sheet microscopy to examine the mitochondrial network in mouse embryonic fibroblasts...
February 23, 2018: Science
https://www.readbyqxmd.com/read/29472219/exhibition-charles-i-king-and-collector-all-the-king-s-pictures
#13
Roger Jones
No abstract text is available yet for this article.
March 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29472201/hard-data
#14
Roger Jones
No abstract text is available yet for this article.
March 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29472178/telegerontology-as-a-novel-approach-to-address-health-and-safety-by-supporting-community-based-rural-dementia-care-triads-randomized-controlled-trial-protocol
#15
Elizabeth M Wallack, Chelsea Harris, Michelle Ploughman, Roger Butler
BACKGROUND: Telegerontology is an approach using videoconferencing to connect an interdisciplinary team in a regional specialty center to patients in rural communities, which is becoming increasingly practical for addressing current limitations in rural community-based dementia care. OBJECTIVE: Using the remotely-delivered expertise of the Telegerontology dementia care team, we aim to enhance the caregiver/patient/physician triad and thereby provide the necessary support for the person with dementia to "age in place...
February 22, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29471847/the-impact-of-metallothionein-ii-on-microglial-response-to-tumor-necrosis-factor-alpha-tnf%C3%AE-and-downstream-effects-on-neuronal-regeneration
#16
Jacqueline Y K Leung, William R Bennett, Anna E King, Roger S Chung
BACKGROUND: The extracellular environment plays an important role in supporting the regeneration of axons after injury. Metallothionein-II (MTII) is a metal-binding protein known for its neuroprotective effect by directly stimulating the growth of axons after injury. Previous studies have shown that MTII also modulates the response of astrocytes and microglia after injury. However, a detailed analysis describing how MTII modulates the interaction between microglia and neurons is lacking...
February 22, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29471579/extrahemostatic-functions-of-platelets-and-coagulation-factors
#17
Roger J S Preston, Ton Lisman
No abstract text is available yet for this article.
March 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29471539/breaking-down-barriers-to-the-utilization-of-standardized-tests-and-outcome-measures-in-acute-care-physical-therapist-practice-an-observational-longitudinal-study
#18
Brian McDonnell, Shannon Stilwell, Shelby Hart, Roger B Davis
Background: Standardized tests and outcome measures (STOM) have not been consistently implemented as part of most physical therapists' practice. Incidence of STOM use amongst physical therapists at Beth Israel Deaconess Medical Center was similar to low levels cited nationally among acute care physical therapists. Targeted knowledge translation (KT) strategies have been suggested to promote the application of research evidence into clinical decision making. Purpose: The purpose of this quality improvement (QI) effort was to implement a series of interventions aimed at increasing both use and interpretation of STOM by physical therapists practicing in acute care...
February 19, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29471401/influence-of-tree-size-and-application-rate-on-expression-of-thiamethoxam-in-citrus-and-its-efficacy-against-diaphorina-citri-hemiptera-liviidae
#19
K W Langdon, R Schumann, L L Stelinski, M E Rogers
Neonicotinoids are a key group of insecticides used to manage Diaphorina citri Kuwayama (Hemiptera: Liviidae), in Florida citrus. Diaphorina citri is the vector of Candidatus Liberibacter asiaticus, the presumed causal agent of huanglongbing, a worldwide disease of citrus. A two-season field study was conducted to evaluate the effect of tree size and application rate on the expression of thiamethoxam in young citrus following application to the soil. D. citri adult and nymph abundance was also correlated with thiamethoxam titer in leaves...
February 20, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29471198/gaze-patterns-reveal-how-situation-models-and-text-representations-contribute-to-episodic-text-memory
#20
Roger Johansson, Franziska Oren, Kenneth Holmqvist
When recalling something you have previously read, to what degree will such episodic remembering activate a situation model of described events versus a memory representation of the text itself? The present study was designed to address this question by recording eye movements of participants who recalled previously read texts while looking at a blank screen. An accumulating body of research has demonstrated that spontaneous eye movements occur during episodic memory retrieval and that fixation locations from such gaze patterns to a large degree overlap with the visuospatial layout of the recalled information...
February 19, 2018: Cognition
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