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Emily Morgan, Roger Levy
We ask whether word order preferences for binomial expressions of the form A and B (e.g. bread and butter) are driven by abstract linguistic knowledge of ordering constraints referencing the semantic, phonological, and lexical properties of the constituent words, or by prior direct experience with the specific items in questions. Using forced-choice and self-paced reading tasks, we demonstrate that online processing of never-before-seen binomials is influenced by abstract knowledge of ordering constraints, which we estimate with a probabilistic model...
October 21, 2016: Cognition
Sterling L Karakula, Roger D Weiss, Margaret L Griffin, Allison M Borges, Allen J Bailey, R Kathryn McHugh
BACKGROUND: Among those with opioid use disorder, heroin use is associated with poorer prognosis relative to use of prescription opioids alone. However, relatively little is known about distinguishing features between those who use heroin relative to those who use prescription opioids. In the present study we evaluated differences in delay discounting in those with opioid use disorder based on primary opioid of use. Delay discounting is associated with a range of negative outcomes and is an important therapeutic target in this population...
October 17, 2016: Drug and Alcohol Dependence
Ingo Hoffmann, Miriam Simon, Anja Hörmann, Thorsten Gravert, Peggy Heunemann, Sarah E Rogers, Michael Gradzielski
Nanoemulsions are metastable emulsions with droplet sizes between 20 and 100 nm with a wide range of applications e.g. in polymerization, in pharmaceutical and cos- metic formulations and as drug delivery systems. Even though they are not in ther- modynamic equilibrium, they can be metastable over relatively long times and have the advantage that they can be formed easily by low energy input methods. In par- ticular, the phase inversion concentration method (PIC) allows to form nanoemulsions simply by diluting a suitable mixture of oil and surfactants with water...
October 24, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Zuzana Novak, Mary Aglipay, Nick Barrowman, Keith O Yeates, Miriam H Beauchamp, Jocelyn Gravel, Stephen B Freedman, Isabelle Gagnon, Gerard Gioia, Kathy Boutis, Emma Burns, Andrée-Anne Ledoux, Martin H Osmond, Roger L Zemek
Importance: Persistent postconcussion symptoms (PPCS) pose long-term challenges and can negatively affect patients' health-related quality of life (HRQoL). To date, no large comprehensive study has addressed the association between PPCS and HRQoL. Objectives: To determine the association between HRQoL and PPCS at 4 weeks after concussion and assess the degree of impairment of HRQoL in the subsequent 12 weeks. Design, Setting, and Participants: In a prospective, multicenter cohort study (Predicting Persistent Postconcussive Problems in Pediatrics [5P]) from August 14, 2013, to September 30, 2014, children aged 5 to 18 years who presented to the emergency department within 48 hours after head injury and were considered to have an acute concussion were enrolled across 9 pediatric emergency departments within the Pediatric Emergency Research Canada Network...
October 24, 2016: JAMA Pediatrics
Lulu Jiang, Charles C T Hindmarch, Mark Rogers, Colin Campbell, Christy Waterfall, Jane Coghill, Peter W Mathieson, Gavin I Welsh
Glucocorticoids are steroids that reduce inflammation and are used as immunosuppressive drugs for many diseases. They are also the mainstay for the treatment of minimal change nephropathy (MCN), which is characterised by an absence of inflammation. Their mechanisms of action remain elusive. Evidence suggests that immunomodulatory drugs can directly act on glomerular epithelial cells or 'podocytes', the cell type which is the main target of injury in MCN. To understand the nature of glucocorticoid effects on non-immune cell functions, we generated RNA sequencing data from human podocyte cell lines and identified the genes that are significantly regulated in dexamethasone-treated podocytes compared to vehicle-treated cells...
October 24, 2016: Scientific Reports
Ana Filipa M Cláudio, Jorge F B Pereira, Parker D McCrary, Mara G Freire, João A P Coutinho, Robin D Rogers
An extensive study on the formation of aqueous biphasic systems (ABS) using aqueous solutions of protic ionic liquids (PILs) and polyethylene glycol (PEG) was performed in order to understand the mechanisms underlying the phase separation. Aqueous solutions of PEG polymers with different molecular weights (600, 1000, 2000, and 3400 g mol(-1)) and several N-alkyl-, dialkyl-, and trialkyl-ammonium salts of acetate, propanoate, butanoate, hexanoate and octanoate were prepared and their ability to form ABS at several temperatures assessed...
October 24, 2016: Physical Chemistry Chemical Physics: PCCP
Justin R Lenhard, Jonathan S Gall, Jurgen B Bulitta, Visanu Thamlikitkul, Cornelia B Landersdorfer, Alan Forrest, Roger L Nation, Jian Li, Brian T Tsuji
The objective of this study was to determine the comparative pharmacodynamics of four different carbapenems in combination with polymyxin B (PMB) against carbapenem-resistant Acinetobacter baumannii isolates using time-kill experiments at two different inocula. Two A. baumannii strains (03-149-1 and N16870) with carbapenem minimum inhibitory concentrations (MICs) ranging from 8 to 64 mg/L were investigated in 48-h time-kill experiments using starting inocula of 10(6) CFU/mL and 10(8) CFU/mL. Concentration arrays of ertapenem, doripenem, meropenem and imipenem at 0...
September 20, 2016: International Journal of Antimicrobial Agents
Kelly Olds, Neil Langlois, Roger Byard, Calle Winskog
No abstract text is available yet for this article.
February 2016: Pathology
Stephanie Richards, Jane Munro, Roger Allen, C W Chow, Joanne Smart, Sharon Choo
No abstract text is available yet for this article.
February 2016: Pathology
Fiona Moghaddas, Dominic De Nardo, Paul Baker, Lavinia Gordon, Simon Sadedin, Alicia Oshlack, Jonathan Akikusa, Roger Allen, Jane Munro, Justine Ellis, Seth Masters
No abstract text is available yet for this article.
February 2016: Pathology
Roger W Byard
No abstract text is available yet for this article.
February 2016: Pathology
Dinusha Chandratilleke, Roger Silvestrini, Sue Culican, David Campbell, Sanjay Swaminathan, Ming-Wei Lin
No abstract text is available yet for this article.
February 2016: Pathology
Samuel B Goldfarb, Bronwyn J Levvey, Leah B Edwards, Anne I Dipchand, Anna Y Kucheryavaya, Lars H Lund, Bruno Meiser, Joseph W Rossano, Roger D Yusen, Josef Stehlik
No abstract text is available yet for this article.
October 2016: Journal of Heart and Lung Transplantation
Joseph W Rossano, Anne I Dipchand, Leah B Edwards, Samuel Goldfarb, Anna Y Kucheryavaya, Bronwyn J Levvey Rn, Lars H Lund, Bruno Meiser, Roger D Yusen, Josef Stehlik
No abstract text is available yet for this article.
October 2016: Journal of Heart and Lung Transplantation
Roger D Yusen, Leah B Edwards, Anne I Dipchand, Samuel B Goldfarb, Anna Y Kucheryavaya, Bronwyn J Levvey, Lars H Lund, Bruno Meiser, Joseph W Rossano, Josef Stehlik
No abstract text is available yet for this article.
October 2016: Journal of Heart and Lung Transplantation
Lars H Lund, Leah B Edwards, Anne I Dipchand, Samuel Goldfarb, Anna Y Kucheryavaya, Bronwyn J Levvey, Bruno Meiser, Joseph W Rossano, Roger D Yusen, Josef Stehlik
No abstract text is available yet for this article.
October 2016: Journal of Heart and Lung Transplantation
Nel Otting, Marit K H van der Wiel, Nanine de Groot, Annemiek J M de Vos-Rouweler, Natasja G de Groot, Gaby G M Doxiadis, Roger W Wiseman, David H O'Connor, Ronald E Bontrop
The human major histocompatibility complex (MHC) region encodes three types of class II molecules designated HLA-DR, -DQ, and -DP. Both the HLA-DQ and -DP gene region comprise a duplicated tandem of A and B genes, whereas in macaques, only one set of genes is present per region. A substantial sequencing project on the DQ and DP genes in various macaque populations resulted in the detection of previously 304 unreported full-length alleles. Phylogenetic studies showed that humans and macaques share trans-species lineages for the DQA1 and DQB1 genes, whereas the DPA1 and DPB1 lineages in macaques appear to be species-specific...
October 22, 2016: Immunogenetics
Alexander J Hose, Martin Depner, Sabina Illi, Susanne Lau, Thomas Keil, Ulrich Wahn, Oliver Fuchs, Petra Ina Pfefferle, Elisabeth Schmaußer-Hechfellner, Jon Genuneit, Roger Lauener, Anne M Karvonen, Caroline Roduit, Jean-Charles Dalphin, Josef Riedler, Juha Pekkanen, Erika von Mutius, Markus J Ege, Carl Peter Bauer, Johannes Forster, Fred Zepp, Volker Wahn, Antje Schuster, Renate L Bergmann, Karl E Bergmann, Andreas Reich, Linus Grabenhenrich, Bianca Schaub, Georg J Loss, Harald Renz, Michael Kabesch, Marjut Roponen, Anne Hyvärinen, Pekka Tiittanen, Sami Remes, Charlotte Braun-Fahrländer, Remo Frei, Vincent Kaulek, Marie-Laure Dalphin, Gert Doekes, Nicole Blümer, Urs Frey
BACKGROUND: Phenotypes of childhood-onset asthma are characterized by distinct trajectories and functional features. For atopy, definition of phenotypes during childhood is less clear. OBJECTIVE: To define phenotypes of atopic sensitization over the first 6 years of life by a latent class analysis (LCA) integrating three dimensions of atopy: allergen specificity, time course, and levels of specific IgE. METHODS: Phenotypes were defined by LCA in 680 children of the MAS and 766 of the PASTURE birth cohorts and compared to classical non-disjunctive definitions of seasonal, perennial, and food sensitization with respect to atopic diseases and lung function...
October 19, 2016: Journal of Allergy and Clinical Immunology
Ellie Frayne, Susan Coulson, Roger Adams, Glen Croxson, Gordon Waddington
Laterality of function in the orofacial musculature suggests there may be side-to-side asymmetry of proprioceptive acuity in lip movement compared to the temporomandibular joint (TMJ). In the present work, 14 young adults were tested for acuity of lip and TMJ closure movements onto plugs varying from 5 to 8mm without visual feedback. Testing was conducted on both left and right sides, using the same psychophysical task and stimuli. Results showed superior proprioceptive acuity at the lips, with no significant side effect...
October 19, 2016: Neuroscience Letters
Carol Chu, Melanie A Hom, Megan L Rogers, Ian H Stanley, Fallon B Ringer-Moberg, Matthew C Podlogar, Jameson K Hirsch, Thomas E Joiner
BACKGROUND: Insomnia is a robust correlate of suicidal ideation and behavior. Preliminary research has identified thwarted belongingness (c.f. social disconnection) as an explanatory link between insomnia and suicidal ideation. OBJECTIVES: This study replicates and extends previous findings using both cross-sectional and longitudinal designs in four demographically diverse samples. Additionally, the specificity of thwarted belongingness was evaluated by testing anxiety as a rival mediator...
October 11, 2016: Journal of Affective Disorders
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