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pleomorphic adenoma

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https://www.readbyqxmd.com/read/29143959/intracapsular-carcinoma-ex-pleomorphic-adenoma-of-the-parapharyngeal-space-report-of-two-cases-and-review-of-the-literature
#1
Remo Accorona, Diego Barbieri, Davide Farina, Davide Lombardi, Mario Bussi, Piero Nicolai
BACKGROUND: Carcinoma ex-pleomorphic adenoma of the parapharyngeal space is an exceedingly rare entity. METHODS: The clinical records of two patients with primary carcinoma ex-pleomorphic adenoma of the parapharyngeal space surgically treated at two different centers were retrospectively analyzed. RESULTS: Despite ultrasound-guided fine-needle aspiration cytology and magnetic resonance imaging, the correct diagnosis was preoperatively missed in both cases...
November 15, 2017: Tumori
https://www.readbyqxmd.com/read/29141486/recurrent-pleomorphic-adenoma-is-treatment-considerably-delayed-thus-affecting-surgical-morbidity
#2
Eran Glikson, Doron Sagiv, Jobran Mansour, Lev Bedrin, Yoav P Talmi, Eran E Alon
OBJECTIVE: To examine the incidence of late presentation of patients with recurrent pleomorphic adenoma (RPA) of the parotid gland. METHODS: This is a retrospective analysis of patients treated in our center. We examined patients demographics, disease characteristics, treatment, and outcome and as well as the time period length from the first discovery of a recurrent mass until seeking treatment at our clinic and its effect on morbidity. RESULTS: A total of 30 patients were included...
November 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29135520/epithelial-myoepithelial-carcinoma-frequent-morphologic-and-molecular-evidence-of-preexisting-pleomorphic-adenoma-common-hras-mutations-in-plag1-intact-and-hmga2-intact-cases-and-occasional-tp53-fbxw7-and-smarcb1-alterations-in-high-grade-cases
#3
Soufiane El Hallani, Aaron M Udager, Diana Bell, Isabel Fonseca, Lester D R Thompson, Adel Assaad, Abbas Agaimy, Alyssa M Luvison, Caitlyn Miller, Raja R Seethala, Simion Chiosea
We hypothesized that there is a relationship between the preexisting pleomorphic adenoma [PA]), histologic grade of epithelial-myoepithelial carcinomas (EMCAs), and genetic alterations. EMCAs (n=39) were analyzed for morphologic and molecular evidence of preexisting PA (PLAG1, HMGA2 status by fluorescence in situ hybridization, FISH, and FGFR1-PLAG1 fusion by next-generation sequencing, NGS). Twenty-three EMCAs were further analyzed by NGS for mutations and copy number variation in 50 cancer-related genes. On the basis of combined morphologic and molecular evidence of PA, the following subsets of EMCA emerged: (a) EMCAs with morphologic evidence of preexisting PA, but intact PLAG1 and HMGA2 (12/39, 31%), (b) Carcinomas with PLAG1 alterations (9/39, 23%), or (c) HMGA2 alterations (10/39, 26%), and (d) de novo carcinomas, without morphologic or molecular evidence of PA (8/39, 21%)...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29122340/robot-assisted-excision-of-the-submandibular-gland-by-a-postauricular-facelift-approach-comparison-with-the-conventional-transcervical-approach
#4
R P Singh, E S Sung, C M Song, Y B Ji, K Tae
Various approaches have been described for excision of a submandibular gland including endoscopic and robot-assisted techniques. We present the outcome of excision by a robot-assisted postauricular facelift approach and compare it with the conventional transcervical approach. We studied 30 cases of excision of the gland for benign disease (16 transcervical and 14 robot-assisted), and collected clinical and personal data, and details of patients' satisfaction with the result. The most common conditions were sialadenitis (n=15) and pleomorphic adenoma (n=12)...
November 6, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29116049/pleomorphic-adenoma-the-results-of-a-retrospective-analysis-of-104-patients-treated-at-the-clinical-department-of-cranio-maxillofacial-surgery-clinic-of-otolaryngology-and-laryngologic-oncology-of-the-military-institute-of-medicine
#5
Michał Korba, Aldona Chloupek, Jarosław Dąbrowski, Tomasz Piętka, Wojciech Domański, Barbara Biernacka, Wojciech Leśniak
Pleomorphic adenoma, also known as tumor mixtus, is one of the most common types of benign neoplasm of the salivary gland, which presents as a slow growing, painless tumor. Major salivary glands are the typical localization of this neoplasm. It rarely undergoes malignant transformation, however may recur locally post resection. In this study, we present the results of a retrospective analysis of 104 patients treated at the Clinical Department of Cranio-Maxillofacial Surgery, Clinic of Otolaryngology and Laryngologic Oncology of the Military Institute of Medicine between 2004 and 2015 due to pleomorphic adenoma...
August 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29112638/the-role-of-real-time-sonoelastography-in-the-differentiation-of-benign-from-malignant-parotid-gland-tumors
#6
Sumeyra Cortcu, Muzaffer Elmali, Asli Tanrivermis Sayit, Yuksel Terzi
OBJECTIVE: The aims of this study are to evaluate the utility of sonoelastography for parotid gland masses and to determine which cutoff strain ratio (SR) would be best for the differentiation between benign and malignant lesions. METHODS: From August 2015 to December 2016, 39 parotid gland masses were examined prospectively by ultrasonography and strain sonoelastography. Elastographic scores were determined by a 4-point scoring method. Interventional procedures were performed on all patients after sonographic examinations...
November 6, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29108921/micrornas-expression-pattern-related-to-mast-cell-activation-and-angiogenesis-in-paraffin-embedded-salivary-gland-tumors
#7
Poliana Ramos Braga Santos, Claúdia Malheiros Coutinho-Camillo, Fernando Augusto Soares, Valéria Souza Freitas, Deise Souza Vilas-Bôas, Flávia Caló Aquino Xavier, Clarissa Araújo Gurgel Rocha, Iguaracyra Barreto de Araújo, Jean Nunes Dos Santos
The aim of this study was evaluate the expression profile of microRNAs related to mast cells activation and angiogenesis in salivary glands tumors. METHOD: We have analyzed the expression of miR-9, miR-16, miR-17, miR-132, miR-195 and miR-221 by real-time RT-PCR, in 11 adenoid cystic carcinomas, 9 mucoepidermoid carcinomas and 11 pleomorphic adenomas. Immunohistochemical investigation was performed to detect mast cells tryptase and CD-34 for microvessels biomarkers. miR-16, miR-17, miR-132, miR-195 and miR-221 showed a decreased expression, whereas miR-9 showed an increased expression in most cases compared to normal tissues...
October 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29095193/the-effectiveness-of-sternocleidomastoid-flap-versus-superficial-musculoaponeurotic-system-flap-for-the-prevention-of-frey-syndrome-and-facial-depressed-deformity-in-parotid-surgery-for-pleomorphic-adenoma
#8
Marco Manola, Luca Moscillo, Vittorio Simeon, Elena De Luca, Americo Mastella
The purpose of this study was to compare 2 types of reconstruction techniques: sternocleidomastoid (SCM) flap and superficial musculoaponeurotic system (SMAS) flap after partial parotidectomy (PP) for preventing Frey syndrome (FS) and concave facial depressed deformity. A total of 99 patients underwent PP for pleomorphic adenoma of the parotid gland. The patients were divided in 2 groups according to the dimension of the tumor: tumors less than 3 cm (group A, 47 patients) and tumors greater than or equal to 3 cm (group B, 52 patients)...
October 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29055657/correlation-between-computed-tomography-imaging-and-histopathology-in-pleomorphic-adenoma-of-parotid-gland
#9
Heejin Kim, So Young Kim, Yoon-Joong Kim, Jae-Mun Ko, Min Ji Park, Ji Hoon Kim, J Hun Hah, Tack-Kyun Kwon, Kwang Hyun Kim, Myung-Whun Sung
OBJECTIVE: The purpose of this study was to correlate the CT imaging features and histopathological findings of pleomorphic adenomas (PA), and also try to identify its clinical significance. METHODS: Totally 262 PAs in the parotid gland including 18 recurrent cases were retrospectively reviewed with preoperative CT and pathologic slides. Each pathologic slide was reviewed by two pathologists to calculate mean value of epithelial/mesenchymal component, and the results were correlated with features of CT scans...
October 18, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29049099/spontaneous-rupture-of-lacrimal-gland-pleomorphic-adenoma-pivotal-role-in-masquerading-orbital-cellulitis
#10
Farzad Pakdel, Niloofar Pirmarzdashti, Sasan Soltani, Zohreh Nozarian, Fahimeh Asadi Amoli, Abolfazl Kassaee
The authors aim to report a 68-year-old patient presenting with acute swelling and redness of orbital area diagnosed initially as orbital cellulitis. Surgical excision was decided based on clinical and imaging findings with the diagnosis of pleomorphic adenoma of the lacrimal gland. Lacrimal gland pleomorphic adenoma usually presents with painless gradual swelling of upper eyelid. In an exceptionally rare circumstance, this case showed acute orbital inflammation, and imaging findings of orbital inflammation mostly focused around the cystic space of the lacrimal gland tumor...
October 14, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29039996/giant-pleomorphic-adenoma-of-the-lacrimal-gland-a-surgical-challenge
#11
Md Shahid Alam, Varsha Backiavathy, Bipasha Mukherjee
Pleomorphic adenoma is the most common epithelial neoplasm of the lacrimal gland. The tumor typically presents with a superotemporal mass with inferonasal displacement of the globe. They generally measure less than 3 cm in size and can be removed comfortably via a lateral orbitotomy approach. Pleomorphic adenoma left unattended for a long period grows up to humongous proportions and poses a surgical challenge both for its complete removal and globe salvage. We report a rare case of pleomoprphic adenoma of the lacrimal gland in an adult male, who did not seek any medical advice for 20 years allowing the tumor to expand enormously in all dimensions, with complete obscuration of the globe...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/29038635/pleomorphic-adenoma-of-soft-palate-unusual-occurrence-of-the-major-tumor-in-minor-salivary-gland-a-case-report-and-literature-review
#12
Deepak Passi, Hari Ram, Shubha Ranjan Dutta, Laxman Revansidha Malkunje
Salivary gland tumours constitute about less than 4 % of all head and neck tumours. Pleomorphic adenoma, also called benign mixed tumour, is the most common tumour of the salivary glands. About 80-90 % of these tumours occur in the major salivary glands mainly parotid gland and 10 % of them occur in the minor salivary glands. The most common site for pleomorphic adenoma of the minor salivary glands is the palate, followed by the lips and the cheeks. Other rare sites include the floor of the mouth, tongue, tonsil, pharynx, retromolar area and the nasal cavity...
December 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29026716/benign-recurrent-pleomorphic-adenoma-of-the-parotid-gland-with-perineural-space-invasion
#13
EDITORIAL
Luca Roncati, Antonio Maiorana
No abstract text is available yet for this article.
September 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/28994509/cytology-of-breast-pleomorphic-adenoma-associated-with-extensive-apocrine-metaplasia
#14
Takahiko Sakuma, Mikiko Mori, Chikako Kokubo, Keizo Deguchi, Koji Matsuo, Kouichiro Tagami
No abstract text is available yet for this article.
October 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28989535/investigating-the-microrna-mrna-regulatory-network-in-acute-myeloid-leukemia
#15
Haiguo Zhang, Chengfang Zhang, Rui Feng, Haixia Zhang, Min Gao, Ling Ye
Acute myeloid leukemia (AML) is a common myelogenous malignancy in adults that is often characterized by disease relapse. The pathophysiological mechanism of AML has not yet been elucidated. The present study aimed to identify the crucial microRNAs (miRNAs/miRs) and target genes in AML, and to uncover the potential oncogenic mechanism of AML. miRNA and mRNA expression-profiling microarray datasets were downloaded from the Gene Expression Omnibus database. Differential expression analysis was performed and a regulatory network between miRNAs and target genes was constructed...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28987676/value-of-diffusion-tensor-imaging-in-differentiating-malignant-from-benign-parotid-gland-tumors
#16
Koji Takumi, Yoshihiko Fukukura, Hiroto Hakamada, Junichi Ideue, Yuichi Kumagae, Takashi Yoshiura
PURPOSE: To evaluate whether diffusion tensor imaging (DTI) can be used to differentiate malignant parotid gland tumors from the benign ones. MATERIALS AND METHODS: The study population comprised 59 parotid gland tumors (24 Warthin's tumors, 19 pleomorphic adenomas, seven other benign tumors, and nine malignant tumors). Single-shot echo-planar DTI was performed with motion-probing gradients along 30 noncollinear directions (b=1000s/mm(2)) at 3.0T. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values for benign and malignant tumors were compared using the Mann-Whitney U test...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987229/controversies-in-oral-and-maxillofacial-oncology
#17
REVIEW
Kyle S Ettinger, Jacob G Yetzer
Imaging studies are essential components of tumor diagnosis, staging, assessing tumor response to neoadjuvant and adjuvant therapies, and postoperative surveillance on completion of definitive treatment. Treatment of early stage clinically node negative oral cavity squamous cell carcinoma is controversial. Approximately 3% of all head and neck tumors arise within the parotid gland and most often within the superficial lobe, lateral to the facial nerve; about 80% are benign and most are pleomorphic adenoma. In patients with dry eyes failing multiple other treatment modalities and facing ongoing pain and loss of vision, microvascular transplant of the submandibular gland is a viable option...
November 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28975191/extracapsular-dissection-vs-superficial-parotidectomy-of-benign-parotid-lesions-surgical-outcomes-and-cost-effectiveness-analysis
#18
Masanari G Kato, Evren Erkul, Shaun A Nguyen, Terry A Day, Joshua D Hornig, Eric J Lentsch, M Boyd Gillespie
Importance: The clinical implications of extracapsular dissection over superficial parotidectomy are controversial and limited in data on cost-effectiveness. Objective: To compare extracapsular dissection with superficial parotidectomy for benign parotid tumors with respect to surgical outcomes and cost-effectiveness. Design, Setting, and Participants: This was a retrospective medical record review and cost-effectiveness analysis performed from August 2012 to November 2015 at a tertiary care institution...
November 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28972308/lef-1-diagnostic-utility-in-distinguishing-basaloid-neoplasms-of-the-salivary-gland
#19
Alessandra C Schmitt, Christopher C Griffith, Cynthia Cohen, Momin T Siddiqui
BACKGROUND: Lymphoid enhancer binding factor 1 (LEF-1) has recently been reported as a potential immunohistochemical (IHC) marker for basal cell adenoma (BCA) and other salivary gland tumors, which may contribute to an increased accuracy in differentiating basaloid salivary gland neoplasms. We evaluated the utility of LEF-1 in fine needle aspiration (FNA) and resection specimens to distinguish pleomorphic adenoma (PA), BCA, basal cell adenocarcinoma (BCAC), and adenoid cystic carcinoma (ACC) as well as in non-neoplastic salivary gland (NNSG)...
October 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28969297/pleomorphic-adenoma-masquerading-as-odontogenic-lesion-in-the-maxilla
#20
Lavanya Mallika, Dominic Augustine, Parimala Sagar, Kavitha Prasad, Roopa S Rao
No abstract text is available yet for this article.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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