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pleomorphic adenoma

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https://www.readbyqxmd.com/read/29301803/extramedullary-plasmacytoma-rare-neoplasm-of-parotid-gland
#1
Sehrish Abrar, Nasir Ali, Bilal Mazhar Qureshi, Ahmed Nadeem Abbasi
A 45-year-old man presented with left-sided facial swelling. Initial excisional biopsy was done somewhere else without prior imaging and it came out to be pleomorphic adenoma; local imaging after biopsy showed mass over the left parotid gland with ipsilateral lymphadenopathy. On examination, there was a well-circumscribed mass with signs of left facial nerve palsy. He underwent left radical parotidectomy with ipsilateral modified radical neck dissection, and per operatively, it came out to be neoplastic lesion...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29299510/long-term-oncologic-and-functional-outcome-in-pleomorphic-adenomas-of-the-submandibular-gland
#2
Konstantinos Mantsopoulos, Miguel Goncalves, Mirco Schapher, Heinrich Iro
Objectives: The aim of the study was to evaluate the oncologic and functional long-term outcome after surgical therapy of pleomorphic adenomas of the submandibular gland. Methods: The medical charts of all patients treated for pleomorphic adenomas of the submandibular gland by means of submandibulectomy between 2000 and 2016 were studied retrospectively. Patients who had had revision after external primary surgery, as well as patients with insufficient data were excluded from our study sample...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29290205/pleomorphic-adenoma-of-submandibular-gland-with-extensive-cystic-keratinization
#3
Manas Bajpai, Nilesh Pardhe
No abstract text is available yet for this article.
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29285471/brca1-2-mutations-in-salivary-pleomorphic-adenoma-and-carcinoma-ex-pleomorphic-adenoma
#4
Soussan Irani, Farahnaz Bidari-Zerehpoush
Objectives: It is hypothesized that carcinoma-ex-pleomorphic adenoma (Ca-ex-PA) is malignant from the beginning or is a malignant transformation of a recurrent or a long-standing pleomorphic adenoma (PA). The accumulation of genetic instabilities is suggested to be the main reason for malignant transformation in PA. The aim of this study was to determine the prevalence of BRCA1/2 mutations in PA and Ca-ex-PA. Materials and Methods: A total of ninety salivary gland tumors (45 Ca ex-PA and 45 PA) were selected...
November 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29285375/expression-of-topoisomerase-ii-%C3%AE-protein-in-salivary-gland-tumors
#5
Asaf Shvero, Ohad Hilly, Golan Bubis, Yaniv Hamzany, Rumelia Koren, Lea Rath-Wolfson
Salivary glands give rise to approximately 30 histological distinct tumor types, which results in a diagnostic challenge for the pathologist. The present retrospective, immunohistochemical study aimed to evaluate the expression of Topoisomerase II-α, a nuclear enzyme, as a diagnostic and prognostic marker in benign and malignant salivary gland tumors, including leomorphic adenoma, mucoepidermoid carcinoma, acinic cell carcinoma and carcinoma ex-pleomorphic adenoma. A total of 59 cases of benign and malignant salivary gland tumors were included in the present study...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29284907/pleomorphic-adenoma-of-minor-salivary-glands-in-child
#6
Jehona Reçica Ahmedi, Enis Ahmedi, Ferjall Perjuci, Resmije Ademi, Ali Gashi, Zana Agani, Fisnik Kurshumliu, Bylbyl Reçica
Introduction: Tumors of salivary glands are very rare in children overall, and rarely in minor salivary glands. Among them pleoomorphic adenoma (PA) is the most common benign tumor of salivary glands in children and it acounts 60% of all salivary neoplasms, frequently found in major salivary glands (85 %) and rarely in minor salivary glands (10-15%). PA appears as painless oval mass, elastic consistency and smooth surface. It characterized by slow evolution of growing. The diagnosis can be confirmed only by histopathological features, after total excision of the lesion...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29283337/oncocytic-adreno-cortical-tumors-pathological-features-of-16-cases-and-review-of-the-literature
#7
Yesim Ertan, Asuman Argon, Murat Özdemir, Banu Pınar Sarer Yürekli, Zafer Dökümcü, Özer Makay
Oncocytic neoplasms of the adrenal gland are extremely rare tumors. These tumors differ from their nononcocytic counterparts in some respects. The aim of this study was to review and discuss the clinical, histological, and immunohistochemical features of as well as the prognosis for these rare tumors. In total, 16 cases diagnosed as adrenocortical oncocytic neoplasms between January 2011 and December 2016 were included in the study. The demographic data, gross characteristics, histological data, and immunohistochemical data (Chromogranin-A, Synaptophysin, α-Inhibin, Melan-A, Ki67, PHH3) were reevaluated...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29278551/the-recurrent-pleomorphic-adenoma-conundrum
#8
Patrick J Bradley
PURPOSE OF REVIEW: Recurrent pleomorphic adenoma (RPA) is uncommon. Treatment selection is based on the likely possibility of minimizing the risk of tumour recurrence, avoiding local functional and cosmetic sequelae, and eradicates the possibility of metastatic or malignant transformation. Much has changed since the topic was reviewed in 2001, and this manuscript comments on clinical progress and discusses patient treatment options. RECENT FINDINGS: Surgery is the preferred treatment for head and neck pleomorphic adenoma...
December 22, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29249655/the-plag1-gdh1-axis-promotes-anoikis-resistance-and-tumor-metastasis-through-camkk2-ampk-signaling-in-lkb1-deficient-lung-cancer
#9
Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Avi Kumar, Guojing Zhang, Youna Ha, Dan Li, Gina N Alesi, Yibin Kang, Lu Zhou, Wen-Mei Yu, Kelly R Magliocca, Fadlo R Khuri, Cheng-Kui Qu, Christian Metallo, Taofeek K Owonikoko, Sumin Kang
Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer, but the development of targeted agents is in its infancy. Here we report that a glutaminolytic enzyme, glutamate dehydrogenase 1 (GDH1), upregulated upon detachment via pleomorphic adenoma gene 1 (PLAG1), provides anti-anoikis and pro-metastatic signals in LKB1-deficient lung cancer. Mechanistically, the GDH1 product α-KG activates CamKK2 by enhancing its substrate AMPK binding, which contributes to energy production that confers anoikis resistance...
December 12, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29246390/the-extent-of-surgery-for-benign-parotid-pathology-and-its-influence-on-complications-a-prospective-cohort-analysis
#10
Wai Keat Wong, Subhaschandra Shetty
BACKGROUND: The surgical management of benign parotid tumors is aimed at complete extirpation of the mass with preservation of facial nerve function. There is a relative paucity of literature pertaining to complications after benign parotid surgery and related risk factors. We aim to critically review the outcomes following treatment of benign parotid pathology when surgery entailed either complete superficial parotidectomy (CSP), partial superficial parotidectomy (PSP) or extracapsular dissection (ECD)...
November 29, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29229364/pathology-and-management-of-masses-in-the-accessory-parotid-gland-region-24-year-experience-at-a-single-institution
#11
Hailong Ma, Shufang Jin, Zhong Du, Lizhen Wang, Zhiyuan Zhang, Yan'an Wang
PURPOSE: Masses in the accessory parotid gland (APG) region are clinically rare and their management can lead to conflicts between the need for tumor resection and facial cosmesis. The aim of this study was to analyze the pathological classifications and management of APG lesions in our hospital. MATERIALS AND METHODS: From January 1993 to March 2017, 130 patients with primary tumors in the APG region who underwent surgical treatment were enrolled. Follow-up surveys after surgery were then carried out...
November 17, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29227411/intraoral-pleomorphic-adenoma-in-young-patients
#12
Violante Lina Assunção Alves, Maria Eduarda Pérez-de-Oliveira, Jurema Freire Lisboa de Castro, Camila Lins Vieira, Jair Carneiro Leão, Danyel Elias da Cruz Perez
BACKGROUND: Intraoral pleomorphic adenoma (PA) is rare in young individuals, with only single clinical reports or small patient series reported previously. AIM: The aim of this study was to describe the clinicopathological features of PA in 4 patients under 18 years of age, and to discuss the differential diagnosis of pediatric patients presenting with intraoral submucosal nodules. METHODS: Between 2000 and 2015, all patients of intraoral PA in patients aged ≤18 years diagnosed in the Oral Pathology Laboratory of the Universidade Federal de Pernambuco, Brazil, were retrieved for the study...
December 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29207084/promoter-hypermethylation-may-contribute-to-e%C3%A2-cadherin-repression-in-the-human-salivary-carcinoma-ex-pleomorphic-adenoma
#13
Liang Xia, Yuhua Hu, Ting Gu, Lizhen Wang, Zhen Tian
The role of promoter methylation in the inactivation of E‑cadherin (CDH1) in salivary carcinoma ex pleomorphic adenoma (CXPA) is unknown. The objective of this study was to determine the role and potential clinical implications of CDH1 promoter methylation in salivary CXPA. The CDH1 promoter methylation status was determined by bisulfite sequencing PCR in 37 primary CXPA tissues and 2 CXPA cell lines. E‑cadherin expression levels were determined by immunohistochemical analysis of each tumor. E‑cadherin protein levels and CDH1 mRNA levels were examined by immunoblotting and quantitative real-time PCR, respectively, in 2 CXPA cell lines...
November 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29190876/-use-of-transmandibular-approach-for-resection-of-a-relapse-pleomorphic-adenoma-on-the-parapharyngeal-space
#14
Laura Elena Franco-Garrocho, Jorge Raúl Pérez-Frutos, Juan Guillermo Sánchez-Acuña, Miriam Alejandra Veras-Hernándezc
In this review of a clinical case we study the most frequent benign neoplasia of the main salivary glands. We present the case of a four-year relapse of a patient post-operated of a conservative total parotidectomy. We expose different opinions about this neoplasia, and the clinical case of a 50-year old female patient that presents a relapse to the parapharyngeal space, for which we used a trans-mandibular approach.
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29187728/pleomorphic-adenoma-of-the-posterior-surface-of-the-soft-palate-causing-sleep-disturbance-a-case-report
#15
Uzdan Uz, Onur Celik
BACKGROUND Pleomorphic adenoma is the most common benign tumor arising in the salivary gland. The signs and symptoms of pleomorphic adenoma of the minor salivary glands vary, depending on the anatomical site involved. A rare case of pleomorphic adenoma of the posterior surface of the soft palate is reported that caused sleep disturbance, which was resolved with endoscopic surgical treatment. CASE REPORT A 32-year-old woman experienced snoring and mouth-breathing during sleep. Flexible fiberoptic nasopharyngoscopy imaging of the oropharyngeal passage showed obstruction by a tumor the soft palate, which obstructed the oropharyngeal passage...
November 30, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29178364/fine-needle-aspiration-cytology-for-parotid-lesions-can-we-avoid-surgery
#16
Yotam Shkedy, Uri Alkan, Aviram Mizrahi, Tzippy Shochat, Orr Dimitstein, Sara Morgenstern, Thomas Shpitzer, Gideon Bachar
OBJECTIVE: Salivary gland neoplasms are rare tumors, with most arising in the parotid gland. Fine-needle aspiration cytology (FNAC) is a common method for pre-operative evaluation of parotid masses, although its usefulness is controversial. This study was designed to evaluate the accuracy of FNAC in a large cohort of patients, with emphasis on diagnosis of benign tumors and especially Warthin tumor which can be managed conservatively. STUDY DESIGN: Retrospective case series with chart review...
November 27, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29143959/intracapsular-carcinoma-ex-pleomorphic-adenoma-of-the-parapharyngeal-space-report-of-two-cases-and-review-of-the-literature
#17
Remo Accorona, Diego Barbieri, Davide Farina, Davide Lombardi, Mario Bussi, Piero Nicolai
BACKGROUND: Carcinoma ex-pleomorphic adenoma of the parapharyngeal space is an exceedingly rare entity. METHODS: The clinical records of two patients with primary carcinoma ex-pleomorphic adenoma of the parapharyngeal space surgically treated at two different centers were retrospectively analyzed. RESULTS: Despite ultrasound-guided fine-needle aspiration cytology and magnetic resonance imaging, the correct diagnosis was preoperatively missed in both cases...
November 15, 2017: Tumori
https://www.readbyqxmd.com/read/29141486/recurrent-pleomorphic-adenoma-is-treatment-considerably-delayed-thus-affecting-surgical-morbidity
#18
Eran Glikson, Doron Sagiv, Jobran Mansour, Lev Bedrin, Yoav P Talmi, Eran E Alon
OBJECTIVE: To examine the incidence of late presentation of patients with recurrent pleomorphic adenoma (RPA) of the parotid gland. METHODS: This is a retrospective analysis of patients treated in our center. We examined patients demographics, disease characteristics, treatment, and outcome and as well as the time period length from the first discovery of a recurrent mass until seeking treatment at our clinic and its effect on morbidity. RESULTS: A total of 30 patients were included...
November 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29135520/epithelial-myoepithelial-carcinoma-frequent-morphologic-and-molecular-evidence-of-preexisting-pleomorphic-adenoma-common-hras-mutations-in-plag1-intact-and-hmga2-intact-cases-and-occasional-tp53-fbxw7-and-smarcb1-alterations-in-high-grade-cases
#19
Soufiane El Hallani, Aaron M Udager, Diana Bell, Isabel Fonseca, Lester D R Thompson, Adel Assaad, Abbas Agaimy, Alyssa M Luvison, Caitlyn Miller, Raja R Seethala, Simion Chiosea
We hypothesized that there is a relationship between the preexisting pleomorphic adenoma [PA]), histologic grade of epithelial-myoepithelial carcinomas (EMCAs), and genetic alterations. EMCAs (n=39) were analyzed for morphologic and molecular evidence of preexisting PA (PLAG1, HMGA2 status by fluorescence in situ hybridization, FISH, and FGFR1-PLAG1 fusion by next-generation sequencing, NGS). Twenty-three EMCAs were further analyzed by NGS for mutations and copy number variation in 50 cancer-related genes. On the basis of combined morphologic and molecular evidence of PA, the following subsets of EMCA emerged: (a) EMCAs with morphologic evidence of preexisting PA, but intact PLAG1 and HMGA2 (12/39, 31%), (b) Carcinomas with PLAG1 alterations (9/39, 23%), or (c) HMGA2 alterations (10/39, 26%), and (d) de novo carcinomas, without morphologic or molecular evidence of PA (8/39, 21%)...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29122340/robot-assisted-excision-of-the-submandibular-gland-by-a-postauricular-facelift-approach-comparison-with-the-conventional-transcervical-approach
#20
R P Singh, E S Sung, C M Song, Y B Ji, K Tae
Various approaches have been described for excision of a submandibular gland including endoscopic and robot-assisted techniques. We present the outcome of excision by a robot-assisted postauricular facelift approach and compare it with the conventional transcervical approach. We studied 30 cases of excision of the gland for benign disease (16 transcervical and 14 robot-assisted), and collected clinical and personal data, and details of patients' satisfaction with the result. The most common conditions were sialadenitis (n=15) and pleomorphic adenoma (n=12)...
November 6, 2017: British Journal of Oral & Maxillofacial Surgery
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