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pleomorphic adenoma

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https://www.readbyqxmd.com/read/28819618/serum-levels-of-cyfra-21-in-patients-with-benign-and-malignant-salivary-gland-tumors
#1
Naghmeh Jeiroodi, Seyed Mohammad-Javad Aslani, Bijan Khademi, Mahyar Malekzadeh, Zohreh Jaafari-Ashkavandi
INTRODUCTION: Cyfra 21 is a serum-soluble fragment of cytokeratin19. Increased Cyfra 21 serum levels and their benefit as a tumor marker have been shown in some malignancies. This study aimed to evaluate the serum levels of Cyfra 21 in patients with benign and malignant salivary gland tumors. MATERIALS AND METHODS: In this cross-sectional study, the serum level of Cyfra 21 in 44 patients with malignant salivary gland tumors and 16 cases of pleomorphic adenoma were compared with 28 healthy controls using enzyme-linked immunosorbent assay (ELISA)...
July 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28796899/plag1-immunohistochemistry-is-a-sensitive-marker-for-pleomorphic-adenoma-a-comparative-study-with-plag1-genetic-abnormalities
#2
Nora Katabi, Bin Xu, Achim A Jungbluth, Lei Zhang, Sung Yun Shao, Jason Lane, Ronald Ghossein, Cristina R Antonescu
AIMS: PLAG1 gene rearrangement is the most common genetic abnormality in pleomorphic adenoma (PA), resulting in overexpression of PLAG1 protein. PA and carcinoma ex pleomorphic adenoma (CA ex-PA) can mimic various benign and malignant salivary gland tumors. The aims of this study are to evaluate the sensitivity and specificity of PLAG1 immunohistochemistry (IHC) in the differential diagnosis of PA and CA ex-PA and to compare the PLAG1 immunohistochemical results to PLAG1 gene abnormalities as detected by fluorescence in situ hybridization (FISH)...
August 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28772134/expression-of-c-x-c-motif-chemokine-receptors-4-and-7-in-salivary-gland-neoplasms
#3
Ekarat Phattarataratip, Kittipong Dhanuthai
OBJECTIVES: Chemokine receptors have been shown to overexpress in several cancer types. Binding of chemokines to their cognate chemokine receptors on tumor cells can promote tumor growth, angiogenesis and metastasis. The purposes of this study was to examine the expression of chemokine receptors, CXCR4 and CXCR7, in salivary gland neoplasms and its association with pathologic characteristics. DESIGN: Sixty-two cases of salivary gland neoplasms, including 25 mucoepidermoid carcinomas (MEC), 18 adenoid cystic carcinomas (ACC), 14 pleomorphic adenomas (PA) and 5 polymorphous low-grade adenocarcinoma (PLGA) were investigated for CXCR4 and CXCR7 expression immunohistochemically...
July 26, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28739497/salivary-gland-epithelial-neoplasms-in-pediatric-population-a-single-institute-experience-with-a-focus-on-the-histologic-spectrum-and-clinical-outcome
#4
Bin Xu, Amandeep Aneja, Ronald Ghossein, Nora Katabi
Salivary gland epithelial neoplasms are rare in children and adolescents with only a handful of large series have been published. A retrospective study was conducted for 57 cases in patients 20years or younger. The tumors were located in the parotid (n=36), submandibular gland (n=7), and minor salivary glands (n=14). 19 (33%) tumors were pleomorphic adenoma, while the remaining (67%) were malignant. The histologic types of carcinomas were mucoepidermoid carcinoma (MEC, n=19, 33%), acinic cell carcinoma (n=7, 12%), adenoid cystic carcinoma (n=6, 11%), secretory carcinoma (mammary analogue) (SC, n=4, 7%), and myoepithelial carcinoma (n=2, 4%)...
July 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28713752/largest-de-novo-parapharyngeal-pleomorphic-adenoma-a-rare-case-removed-via-minimal-access-approach
#5
Vikas Malhotra, Nikhil Arora, Varun Rai
Parapharyngeal tumors are relatively rare tumors of head and neck. In general, pleomorphic adenoma is one of the most common benign tumor of the parapharyngeal region. Various approaches have been described in the literature for removal of parapharyngeal tumor with mandibulotomy generally carried out for large tumors. Here, we describe removal of a large parapharyngeal pleomorphic adenoma transcervically without mandibulotomy which subsequently turned out to be one of the largest ever reported in the literature and describe how large tumors of parapharyngeal can be removed with minimal invasive approach with mandibulotomy kept as a backup thereby avoiding complications associated with mandibulotomy...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713740/the-effects-of-platelet-rich-fibrin-membrane-on-secondary-healing-after-pleomorphic-adenoma-excision-in-the-hard-palate-a-preliminary-study
#6
Özer Erdem Gür, Nuray Ensari, Nevreste Didem Sonbay Yılmaz
AIM: This study aims to evaluate the effects of platelet-rich fibrin (PRF) membrane on secondary healing after pleomorphic adenoma (PA) excision in the hard palate. MATERIALS AND METHODS: PRF membranes were laid over mucosal defects which occurred following PA excision in the hard palate. The secondary healing process was monitored in the patients by follow-up examinations on postoperative days 5, 10, 15, 20, 25, 30, 35, and 40. RESULTS: In this preliminary study, epithelialization was observed to have completed on the 30(th) day of follow-up in the first patient and on the 35(th) day in the second and third patients...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28706261/plag1-deficiency-impairs-spermatogenesis-and-sperm-motility-in-mice
#7
Almas R Juma, Sylvia V H Grommen, Moira K O'Bryan, Anne E O'Connor, D Jo Merriner, Nathan E Hall, Stephen R Doyle, Pauliina E Damdimopoulou, Daniel Barriga, Adam H Hart, Wim J M Van de Ven, Bert De Groef
Deficiency in pleomorphic adenoma gene 1 (PLAG1) leads to reduced fertility in male mice, but the mechanism by which PLAG1 contributes to reproduction is unknown. To investigate the involvement of PLAG1 in testicular function, we determined (i) the spatial distribution of PLAG1 in the testis using X-gal staining; (ii) transcriptomic consequences of PLAG1 deficiency in knock-out and heterozygous mice compared to wild-type mice using RNA-seq; and (iii) morphological and functional consequences of PLAG1 deficiency by determining testicular histology, daily sperm production and sperm motility in knock-out and wild-type mice...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704680/differentiating-parotid-tumors-by-quantitative-signal-intensity-evaluation-on-mr-imaging
#8
Eiji Matsusue, Yoshio Fujihara, Eiken Matsuda, Yusuke Tokuyasu, Shu Nakamoto, Kazuhiko Nakamura, Toshihide Ogawa
BACKGROUND: There have been no reports about quantitative evaluations of enhancing components of parotid tumors on conventional MR imaging. PURPOSE: To evaluate the signal intensity of the enhancing components of tumors, including pleomorphic adenomas (PAs), Warthin tumors (WTs) and malignant tumors (MTs), on various MR sequences and to assess the usefulness of quantitative evaluations for differentiation among the three groups of tumors. MATERIAL AND METHODS: A total of 39 histologically proven tumors, including 15 PAs, 17 WTs and 7 MTs, were enrolled in this study...
July 4, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28690748/parapharyngeal-space-pleomorphic-adenoma-a-case-report
#9
Moncef Sellami, Slim Charfi
No abstract text is available yet for this article.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28681314/expression-of-hormone-receptors-and-her-2-in-benign-and-malignant-salivary-gland-tumors
#10
Nhu Thuy Can, Mark W Lingen, Heather Mashek, James McElherne, Renee Briese, Carrie Fitzpatrick, Annemieke van Zante, Nicole A Cipriani
With the advent of targeted therapies, expression of sex hormone receptors and HER-2 in salivary gland tumors (SGTs) is of clinical interest. Previous reports of estrogen (ER) and progesterone (PR) receptor expression have varied. Androgen receptor (AR) and HER-2 overexpression are frequently reported in salivary duct carcinoma (SDC), but have not been studied systematically in other SGTs. This study examines ER, PR, AR, and HER-2 expression in SGTs. Immunohistochemistry for ER, PR, AR, and HER-2 was performed on 254 SGTs (134 malignant)...
July 5, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28680294/carcinoma-ex-pleomorphic-adenoma-case-report-and-options-for-systemic-therapy
#11
N Chooback, Y Shen, M Jones, K Kasaian, M Martin, T Ng, T Thomson, M Marra, J Laskin, C Ho
The most common benign salivary tumour is a pleomorphic adenoma. Transformation to malignancy, carcinoma ex pleomorphic adenoma (cxpa), occurs in 6% of cases. Management focuses on surgical resection and radiotherapy; however, rare cases require systemic management. We present the case of a 60-year-old woman with a cxpa of the left parotid gland who required systemic therapy for locally recurrent disease. Treatment options were guided by the literature concerning malignant salivary gland tumour and by whole-genome and transcriptome sequencing of the tumour...
June 2017: Current Oncology
https://www.readbyqxmd.com/read/28668473/multiple-recurrences-require-long-term-follow-up-in-patients-diagnosed-with-spindle-cell-oncocytoma-of-the-sella-turcica
#12
Branavan Manoranjan, Alex Koziarz, Michelle M Kameda-Smith, John P Provias
Spindle cell oncocytoma (SCO) of the sella turcica is characterized as a WHO grade I non-endocrine neoplasm of the sella turcica. Histologically, these tumors contain spindled and variably oncocytic cellular processes. Although SCOs lack immunoreactivity for neuroendocrine markers and pituitary hormones, they are clinically indistinguishable from non-functioning pituitary adenomas. In contrast to the initially described benign clinical course, several reports have subsequently illustrated cases with multiple recurrences with or without histological features of anaplasia in the form of nuclear pleomorphism, frequent mitoses, high Ki-67 index, and/or necrosis...
June 28, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28658924/a-case-report-of-rare-carcinoma-ex-pleomorphic-adenoma-of-submandibular-gland-and-its-detailed-description
#13
Kirti Balkrishna Buva, Ajinkya Amritrao Deshmukh, Atul A Deshmukh
A 65-year-old female patient reported with a chief complaint of swelling in the left lower region of the jaw since two years. On clinical examination, the swelling was present on the mandibular left posterior region and measuring approximately 6.2 cm antero-posteriorly × 6.2 cm mediolaterally × 8.7 cm superioinferiorly. Initially, it was non tender but eventually it became tender. Fine needle aspiration was done to rule out any salivary gland pathology and report obtained was carcinoma ex pleomorphic adenoma...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28658793/mucoepidermoid-carcinoma-of-salivary-gland-limitations-and-pitfalls-on-fna
#14
Geetha Vasudevan, Arijit Bishnu, Brij Mohan Kumar Singh, Varun Kumar Singh
Mucoepidermoid Carcinoma (MEC) is the most common malignant neoplasm of salivary gland origin. However, its morphologic heterogeneity poses difficulty in interpretation. In the present series we discuss the morphologic features of MEC, limitations and pitfalls in its diagnosis on Fine Needle Aspiration Cytology (FNAC). Fourteen cases of suspected MEC were evaluated cytologically followed by histopathological examination for confirmation. A definite cytological diagnosis was rendered in nine cases; three of the remaining five were underdiagnosed as abscess, pleomorphic adenoma and mucus cyst...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28655435/primary-epithelial-salivary-gland-tumours-in-children-and-adolescents
#15
M Gontarz, G Wyszyńska-Pawelec, J Zapała
Primary epithelial tumours of the salivary glands are very rare in paediatric patients. The aim of this study was to evaluate the clinical course, treatment, and outcomes of these uncommon neoplasms based on the authors' experience and the recent literature. The medical charts of 12 female patients and seven male patients with primary epithelial salivary gland tumours were reviewed. All were under 19 years of age and underwent surgical treatment between 1994 and 2016. The results of this group of paediatric patients were compared with those of 621 adult patients...
June 24, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28655120/a-rare-benign-tumor-of-breast-masquerading-on-fine-needle-aspiration-cytology-a%C3%A2-case%C3%A2-report
#16
Banushree Cs, Ramachandra V Bhat, Sri Vengadesh Gopal
Pleomorphic adenoma is a common tumor encountered in major salivary gland and very rarely seen in breast. This matrix producing tumor can be confused with fibroadenoma, phyllodes tumor and metaplastic carcinoma on fine needle aspiration cytology(FNAC). Pre-operative diagnosis of pleomorphic adenoma helps in preventing surgical over or under treatment of the disease. We present an extremely rare case of pleomorphic adenoma of breast diagnosed on FNAC with histopathological confirmation.
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28650082/circulating-hmga2-and-plag1-in-blood-of-patients-with-oral-squamous-cell-carcinoma
#17
Wenhao Ren, Ling Gao, Fan Li, Cui Qiang, Shaoming Li, Jingjing Zheng, Xinjuan Kong, Jing Deng, Guangfeng Cai, Hao Zhang, Minzhan Zhou, Keqian Zhi
BACKGROUND: High mobility group AT-hook 2 (HMGA2) and pleomorphic adenoma gene 1(PLAG1) have been demonstrated to be elevated in many malignant tumors. However, the aim of this study was to evaluate HMGA2 and PLAG1 levels in blood as a non-invasive biomarker for oral squamous cell carcinoma (OSCC) diagnosis. METHODS: qRT-PCR was performed to measure circulating HMGA2 and PLAG1 levels in OSCC patients (n=43) and matched cancer-free blood control group (n=21). Clinical data of all patients were recorded...
June 26, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28645342/pleomorphic-adenoma-of-an-accessory-lacrimal-gland-masquerading-as-a-chalazion
#18
Yao Wang, Amanda Maltry, Ali Mokhtarzadeh
No abstract text is available yet for this article.
July 2017: Ophthalmology
https://www.readbyqxmd.com/read/28636472/benign-tumors-of-the-parotid-gland-a-retrospective-study-of-339-patients
#19
Marie Quiriny, Cécile Dekeyser, Michel Moreau, Antoine Digonnet, Esther Willemse, Laurent Vanbel, Guy Andry
AIM: Among 339 patients operated for benign tumor of the parotid gland: the recurrences and the postoperative complications rates were compared WITH those published in literature. MATERIALS AND METHODS: About 339 patients operated: 274 primarily and 65 for recurrence or residual tumor. VARIABLES: sex, age, surgical techniques, pre- or postoperative radiotherapy, histology, size and localization of the tumors, disease free intervals, recurrences and postoperative complications...
February 10, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28631686/-laryngeal-pleomorphic-adenoma
#20
D M Mustafaev
Pleomorphic adenomas are the most widespread epithelial tumours originating from the salivary glands. In almost 90% of the cases, they are localized in the parotid salivary glands. Pleomorphic adenomas only rarely affect the larynx. To the best of our knowledge, as many as 27 cases of laryngeal pleomorphic adenoma have thus far been described in the special literature. The present article was designed to report a case of pleomorphic adenoma in the larynx of a 76 year-old male patient. The surgical treatment of this condition proved beneficial for the patient whose condition remains uncomplicated by the relapse of the tumour during the 5 year-long postoperative follow-up...
2017: Vestnik Otorinolaringologii
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