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pleomorphic adenoma

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https://www.readbyqxmd.com/read/28439689/divergent-schwannoma-like-phenotype-in-a-pleomorphic-adenoma
#1
Srinivasa R Chandra, Farah Karim, Yeshwant B Rawal
The schwannoma-like pleomorphic adenoma is a rare histopathological variant of the pleomorphic adenoma. Five previous reports with seven cases exist in English language literature. These tumors present in the parotid gland most commonly. Intraparotid schwannomas of the facial nerve and schwannomas with glandular differentiation have also been reported. A 60-year-old male presented with an asymptomatic swelling over the left angle of the mandible. The swelling had been present for about 12 years with a recent increase in size...
April 24, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28438298/intravoxel-incoherent-motion-magnetic-resonance-imaging-in-head-and-neck-cancer-a-systematic-review-of-the-diagnostic-and-prognostic-value
#2
REVIEW
Daniel P Noij, Roland M Martens, J Tim Marcus, Remco de Bree, C René Leemans, Jonas A Castelijns, Marcus C de Jong, Pim de Graaf
Intravoxel incoherent motion (IVIM) imaging is increasingly applied in the assessment of head and neck cancer (HNC). Our purpose was to determine the diagnostic and prognostic performance of IVIM in HNC by performing a critical review of the literature. Pubmed and EMBASE were searched until May 2016. Study and patients characteristics, imaging protocol and diagnostic or prognostic outcomes were extracted by 2 independent reviewers. The studied IVIM parameters were diffusion coefficient (D), pseudodiffusion coefficient (D∗), and perfusion fraction (f)...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28431798/absence-of-myoepithelial-cells-correlates-with-invasion-and-metastasis-of-carcinoma-ex-pleomorphic-adenoma
#3
P Ye, Y Gao, T Wei, G-Y Yu, X Peng
Myoepithelial cells (MECs) are implicated in the development and progression of human salivary gland tumours. Here, we investigate the potential role for MECs in invasion and metastasis of carcinoma ex pleomorphic adenoma (CXPA). Tumour tissues from 40 CXPA patients diagnosed between 1960 and 2014 were obtained. Patient samples were divided into two groups (non-invasive tumours, n=10; and frankly invasive tumours, n=30). Each group was further divided into two subgroups (metastatic tumours and non-metastatic tumours)...
April 18, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28413869/salivary-duct-carcinoma-with-invasive-micropapillary-and-rhabdoid-feature-arising-in-the-submandibular-gland
#4
Mitsunobu Otsuru, Takayuki Aoki, Yusuke Kondo, Yoshihide Ota, Masashi Sasaki, Takatugu Suzuki, Go Ogura, Nobue Kumaki
Salivary duct carcinoma (SDC) is a high-grade malignant salivary gland tumor associated with poor prognosis, frequent recurrence, and metastasis. An 82-year-old man presented at the department of oral and maxillofacial surgery at Tokai University Hospital with a painless swelling in the right submandibular region that had been there for 20 years. On presentation, an elastic hard tumor, 50 × 50 mm in size, was observed in the submandibular region. Diagnostic imaging was performed, and a malignant tumor in the submandibular gland was suspected...
April 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/28412261/diffusion-and-perfusion-weighted-magnetic-resonance-imaging-an-alternative-to-fine-needle-biopsy-or-only-an-adjunct-test-in-preoperative-differential-diagnostics-of-malignant-and-benign-parotid-tumors
#5
Bogusław Mikaszewski, Karolina Markiet, Aneta Smugała, Dominik Stodulski, Edyta Szurowska, Czesław Stankiewicz
PURPOSE: The role of dynamic magnetic resonance imaging (MRI) in the preoperative differential diagnostics of parotid tumors is unclear. The aim of this study was to compare the accuracy of dynamic MRI and routinely used fine needle biopsy examination in the preoperative differentiation of malignant and benign parotid tumors. MATERIALS AND METHODS: The study included 100 consecutive patients with parotid tumors treated surgically at the authors' center. Accuracy of dynamic MRI and fine needle biopsy examinations in the differential diagnostics of malignant and benign lesions was verified against the gold standard (ie, final histologic diagnosis)...
March 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28409070/a-rare-case-of-a-benign-primary-pleomorphic-adenoma-of-the-lung
#6
Venkatkiran Kanchustambham, Swetha Saladi, Setu Patolia, Sara Mahmoud Assaf, David Stoeckel
Salivary gland tumors (SGT) constitute a small proportion of primary respiratory system neoplasms. Benign SGT comprises pleomorphic adenoma and is exceedingly rare in the lungs. We hereby present a rare case of a benign primary pleomorphic adenoma of the lung. The histological pattern of the tumor was indistinguishable from the head and neck SGT counterparts and showed biphasic morphology. Malignant features were not observed and a metastatic SGT was ruled out. Although little is known about the clinical progression of these rare tumors, surgical resection and interval surveillance remains the treatment of choice...
March 2, 2017: Curēus
https://www.readbyqxmd.com/read/28391078/calcifications-de-la-loge-parotidienne-mise-au-point
#7
S Avignon, J M Foletti, C Collet, L Guyot, C Chossegros
INTRODUCTION: . Parotid lithiasis is the main cause of calcifications in the parotid space. However, there are many other less-known causes. The aim of our study was to point out the non lithiasic causes of calcifications in the parotid space. MATERIAL AND METHODS: We conducted an exhaustive review of the literature by mean of PubMed, using the keywords "parotid" and "calcification" and limiting our analysis to the original articles in humans published in English and in French...
April 5, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28388397/endoscopy-assisted-resection-of-benign-lesions-on-the-base-of-the-tongue-via-the-transoral-approach-using-a-harmonic-scalpel
#8
Song Fan, Da-Ming Zhang, Wei-Liang Chen
PURPOSE: Surgical removal of lesions from the base of the tongue can be challenging for head and neck surgeons. This study evaluated the clinical outcomes of patients with benign lesions at the base of the tongue who underwent endoscopy-assisted resection through the transoral approach using an ultrasonic harmonic scalpel. PATIENTS AND METHODS: This retrospective observational study was conducted from May 2013 to January 2016. Data collected for each patient included age, gender, chief complaints, clinical symptoms, diagnostic imaging, complications after resection, and reported outcomes of resection...
March 14, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28382841/hepatocellular-carcinoma-in-fanconi-bickel-syndrome
#9
Jennifer Pogoriler, Allison F O'Neill, Stephan D Voss, Robert C Shamberger, Antonio R Perez-Atayde
Fanconi-Bickel syndrome is a rare autosomal recessive disorder due to mutations in the facilitative glucose transporter 2 ( GLUT2 or SLC2A2) gene resulting in excessive glycogen storage predominantly in the liver and kidney. Previous case reports of this condition have described liver biopsies with glycogen storage and variable steatosis and/or fibrosis. Unlike in other types of glycogen storage disease, hepatocellular adenomas and carcinomas have not been described to date in this syndrome. A 6-year-old boy with consanguineous parents had short stature, poorly controlled rickets, hepatosplenomegaly, and renal tubular dysfunction clinically consistent with Fanconi-Bickel Syndrome...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28382826/water-clear-cell-adenoma-of-the-parathyroid-gland-a-forgotten-cause-of-primary-hyperparathyroidism
#10
Siba El Hussein, Robert Poppiti
Water clear cell adenoma of the parathyroid gland is a rare neoplasm composed of large clear cells with foamy cytoplasm and mild nuclear pleomorphism, compressing the residual nonneoplastic parathyroid tissue. The differential diagnosis includes a variety of neoplasms with clear cell features. In this article, we provide an overview of the entity with a historical perspective, in order to help pathologists in distinguishing it from other neoplasms in their daily practice.
April 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28370782/preoperative-evaluation-and-surgical-planning-of-submandibular-gland-tumors
#11
Timo Atula, Juha Panigrahi, Jussi Tarkkanen, Antti Mäkitie, Katri Aro
BACKGROUND: Roughly half of submandibular gland neoplasms are malignant. Because preoperative information on the nature of these tumors remains limited, both preoperative evaluation and assessment of the extent of primary surgery warrant guidelines that are more accurate. METHODS: We evaluated the preoperative examinations and management of all submandibular gland neoplasms treated surgically at the Helsinki University Hospital between 2000 and 2010. RESULTS: Of the 83 tumors, 58 (70%) were benign and 25 (30%) were malignant...
March 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28357097/surgical-management-and-follow-up-of-lateral-skull-base-tumors-an-8-year-review
#12
Jie Kong, Hong-Yu Yang, Yu-Fan Wang, Hui-Jun Yang, Shi-Yue Shen, Feng Wang
The purpose of the present article was to describe the diagnostic evaluation of, and surgical approaches to, lateral skull base tumors (LSBTs). The study is a retrospective review of 21 patients diagnosed with tumors that involve lateral skull base (8 with malignant diseases and 13 with benign lesions) who were surgically treated during a 8-year period. The transparotid-transmandibular (38%) was the most commonly performed surgical procedure, followed by the transmandibular (24%), the transmaxillary (24%), the transcervical approach (10%) and the combined approach (4%)...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28357092/extravascular-type-of-intravascular-papillary-endothelial-hyperplasia-mimicking-parotid-gland-neoplasia-and-the-possible-role-of-ferritin-in-the-pathogenesis-a-case-report
#13
Chiara Mignogna, Ida Barca, Anna Di Vito, Francesca Puleo, Natalia Malara, Amerigo Giudice, Mario Giudice, Tullio Barni, Giuseppe Donato, Maria Giulia Cristofaro
Intravascular papillary endothelial hyperplasia (IPEH) is defined as a vascular lesion characterized by extensive proliferation of vascular endothelial cells. This lesion was first described by Pierre Masson in 1923 as intravascular hemangioendothelioma. The most frequent sites of involvement are the skin and subcutis. IPEH comprises ~2% of the vascular tumors of the skin and subcutaneous tissue and it has a predilection for the head, neck, trunk and the extremities. The diagnosis is based on histopathology...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28353089/histological-immunohistological-and-molecular-characteristics-of-intraductal-precursor-of-carcinoma-ex-pleomorphic-adenoma-support-a-multistep-carcinogenic-process
#14
Stephan Ihrler, Orlando Guntinas-Lichius, Abbas Agaimy, Agnes Wolf, Martin Mollenhauer
In recent years, multistep carcinogenesis of carcinoma ex pleomorphic adenoma (CEPA) has been identified, starting with intraductal neoplasia within pre-existent pleomorphic adenoma (PA). However, as yet there is no consensus regarding clinical relevance and appropriate terminology of precursor lesions in CEPA. We therefore decided to investigate precursor lesions, especially intraductal carcinoma, in a series of 85 cases of CEPA. Intraductal carcinoma confined by benign myoepithelial cells was found in 60 cases and mostly exhibited high-grade cellular atypia, increased cellular proliferation and frequent genetic alterations (TP53, Her2-neu, androgen receptor)...
March 28, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28346650/submandibular-salivary-gland-tumors-clinical-course-and-outcome-of-a-20-year-multicenter-study
#15
Aviram Mizrachi, Gideon Bachar, Yaron Unger, Ohad Hilly, Dan M Fliss, Thomas Shpitzer
The purpose of this retrospective chart review study was to review the nature and clinical course of benign and malignant submandibular gland tumors at 2 major university-affiliated tertiary medical centers. All patients who underwent submandibular salivary gland excision between 1990 and 2010 were included. Clinical and disease-related data were collected from the medical charts. One hundred ninety-three patients were identified, of whom 108 (56%) had non-neoplastic disorders (sialolithiasis and sialadenitis)...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28337279/agr2-promotes-the-proliferation-migration-and-regulates-epithelial-mesenchymal-transition-in-salivary-adenoid-cystic-carcinoma
#16
Si-Rui Ma, Liang Mao, Wei-Wei Deng, Yi-Cun Li, Lin-Lin Bu, Guang-Tao Yu, Wen-Feng Zhang, Zhi-Jun Sun
Salivary adenoid cystic carcinoma (AdCC) is a common head and neck cancer with the propensity for local spread and distant metastasis. In our previous study, elevated expression of Anterior gradient 2 (AGR2) was detected in head and neck squamous cell carcinoma (HNSCC), associated with epithelial-mesenchymal transition (EMT) and cancer stemness. However, to date, the expression and function of AGR2 in AdCC has yet to be elucidated. In the present study, human AdCC tissue microarrays including 18 cases of normal salivary gland (NSG), 12 cases of pleomorphic adenoma (PMA) and 72 cases of AdCC were employed for immunohistochemical staining analysis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28326706/-clinical-efficacy-of-the-fine-needle-aspiration-of-the-cell-block-in-the-diagnosis-of-parotid-gland-masses
#17
Chen Hong, Fang Qingquan, Tu Jinhua, Cai Qiaoling, Zhang Suhua
OBJECTIVE: To investigate the clinical significance of cell blocks obtained by ultrasound-guided fine needle aspiration in diagnosing parotid gland masses. METHODS: Cell blocks were made in 285 parotid gland masses by ultrasound-guided fine needle aspiration. Diagnosis was conducted using the cell blocks. Non-tumor masses were subjected to conservative treatment, and cysts and tumors were treated with surgery. The cell block sections from masses with the diagnosis of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) were applied to the detection of immunocytochemical staining for the stem cell factor receptor CD117...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28321072/multiple-metastasizing-pleomorphic-adenomas-of-the-lung
#18
Ayaka Nakai, Kensuke Suzuki, Hideaki Furuse, Takeshi Tsuda, Yasuaki Masaki, Hideki Shinno, Yoshitaka Ito, Hideki Miyazawa, Hirokazu Taniguchi
A 40-year-old woman was referred to our hospital with abnormal findings on chest X-ray. Her medical history was remarkable in that she had presented with a pleomorphic adenoma in the right parotid gland treated by surgical removal approximately 12 years previously. Chest computed tomography showed well-defined non-calcified nodules of the bilateral lobes, so she underwent segmentectomy of the right upper lobe and middle lobe. The histopathological diagnosis was metastasizing pleomorphic adenoma of the lung, a rare entity...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28299426/immunoexpression-of-glut-1-and-angiogenic-index-in-pleomorphic-adenomas-adenoid-cystic-carcinomas-and-mucoepidermoid-carcinomas-of-the-salivary-glands
#19
Lélia Batista de Souza, Lucileide Castro de Oliveira, Cassiano Francisco Weege Nonaka, Maria Luiza Diniz de Sousa Lopes, Leão Pereira Pinto, Lélia Maria Guedes Queiroz
This study aimed to evaluate and compare the immunoexpression of glucose transporter-1 (GLUT-1) and angiogenic index between pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs), and mucoepidermoid carcinomas (MECs) of the salivary glands, and establish associations with the respective subtype/histological grade. Twenty PAs, 20 ACCs, and 10 MECs were submitted to morphological and immunohistochemical analysis. GLUT-1 expression was semi-quantitatively evaluated and angiogenic index was assessed by microvessel counts using anti-CD34 antibody...
March 16, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28299265/the-use-of-buccal-fat-pad-free-graft-in-closure-of-soft-tissue-defects-and-dehiscence-in-the-hard-palate
#20
Fares Kablan
INTRODUCTION: The integrity of the palatal mucosa can be lost due to congenital, pathological, and iatrogenic conditions. Various surgical techniques have been suggested for the closure of palatal defects. The aim of the current study is to present the free buccal fat pad graft as a novel technique to repair the soft-tissue defects at the palate. PATIENTS AND METHODS: During a 2-year period, the free fat tissue graft harvested from the buccal fat pad (BFP) (FBFG) and used to reconstruct five soft-tissue defects of the palate in five patients (2 women, 3 men; mean age, 34 years; range, 22-58 years)...
July 2016: Annals of Maxillofacial Surgery
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