keyword
MENU ▼
Read by QxMD icon Read
search

endo post

keyword
https://www.readbyqxmd.com/read/27754357/microrna-in-control-of-gene-expression-an-overview-of-nuclear-functions
#1
Caterina Catalanotto, Carlo Cogoni, Giuseppe Zardo
The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent improvements in high throughput sequencing and computational prediction methods have allowed the discovery and classification of several types of ncRNAs. Based on their precursor structures, biogenesis pathways and modes of action, ncRNAs are classified as small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs), promoter associate RNAs (pRNAs), small nucleolar RNAs (snoRNAs) and sno-derived RNAs...
October 13, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27743738/impact-of-histology-and-surgical-approach-on-survival-among-women-with-early-stage-high-grade-uterine-cancer-an-nrg-oncology-gynecologic-oncology-group-ancillary-analysis
#2
Amanda N Fader, James Java, Meaghan Tenney, Stephanie Ricci, Camille C Gunderson, Sarah M Temkin, Nick Spirtos, Christina L Kushnir, Michael L Pearl, Oliver Zivanovic, Krishnansu S Tewari, David O'Malley, Ellen M Hartenbach, Chad A Hamilton, Natalie S Gould, Robert S Mannel, William Rodgers, Joan L Walker
OBJECTIVES: We sought to analyze the clinicopathologic features, recurrence patterns and survival outcomes of women with high-grade uterine cancer (UC) enrolled on The Gynecologic Oncology Group (GOG) LAP2 trial. METHODS: This is a post-hoc analysis of LAP-2 patients with grade 3 endometrioid adenocarcinoma (ENDO), uterine serous (USC), clear cell (CC) and carcinosarcoma (CS). Demographics, clinicopathologic features, and recurrence patterns, were compared by histology and surgical approach...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27739052/mercury-removal-during-growth-of-mercury-tolerant-and-self-aggregating-yarrowia-spp
#3
Ganiyu Oladunjoye Oyetibo, Keisuke Miyauchi, Hitoshi Suzuki, Ginro Endo
Ecotoxicological implications of mercury (Hg) pollution of hydrosphere require effective Hg-removal strategies as antidote to the environmental problems. Mercury-tolerant yeasts, Yarrowia spp. Idd1 and Idd2 strains, were studied for intracellular accumulation and extracellular micro-precipitation of Hg during growth stage of the yeast strains. In a liquid medium containing 870 (±23.6) µg of bioavailable Hg(2+), 419.0 µg Hg(2+) (approx.) was taken up by the wet biomasses of the yeast strains after 48 h post-inoculation...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27738323/synergistic-targeting-of-sp1-a-critical-transcription-factor-for-myeloma-cell-growth-and-survival-by-panobinostat-and-proteasome-inhibitors
#4
Ariunzaya Bat-Erdene, Hirokazu Miki, Asuko Oda, Shingen Nakamura, Jumpei Teramachi, Ryota Amachi, Hirofumi Tenshin, Masahiro Hiasa, Masami Iwasa, Takeshi Harada, Shiro Fujii, Kimiko Sogabe, Kumiko Kagawa, Sumiko Yoshida, Itsuro Endo, Kenichi Aihara, Masahiro Abe
Panobinostat, a pan-deacetylase inhibitor, synergistically elicits cytotoxic activity against myeloma (MM) cells in combination with the proteasome inhibitor bortezomib. Because precise mechanisms for panobinostat's anti-MM action still remain elusive, we aimed to clarify the mechanisms of anti-MM effects of panobinostat and its synergism with proteasome inhibitors. Although the transcription factor Sp1 was overexpressed in MM cells, the Sp1 inhibitor terameprocol induced MM cell death in parallel with reduction of IRF4 and cMyc...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27733120/comparative-proteomics-reveals-that-central-metabolism-changes-are-associated-with-resistance-against-sporisorium-scitamineum-in-sugarcane
#5
Yachun Su, Liping Xu, Zhuqing Wang, Qiong Peng, Yuting Yang, Yun Chen, Youxiong Que
BACKGROUND: Sugarcane smut, which is caused by Sporisorium scitamineum, has been threatening global sugarcane production. Breeding smut resistant sugarcane varieties has been proven to be the most effective method of controlling this particular disease. However, a lack of genome information of sugarcane has hindered the development of genome-assisted resistance breeding programs. Furthermore, the molecular basis of sugarcane response to S. scitamineum infection at the proteome level was incomplete and combining proteomic and transcriptional analysis has not yet been conducted...
October 12, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27726178/critical-role-of-ror2-receptor-tyrosine-kinase-in-regulating-cell-cycle-progression-of-reactive-astrocytes-following-brain-injury
#6
Mitsuharu Endo, Guljahan Ubulkasim, Chiho Kobayashi, Reiko Onishi, Atsu Aiba, Yasuhiro Minami
Ror2 receptor tyrosine kinase plays crucial roles in developmental morphogenesis and tissue-/organo-genesis. In the developing brain, Ror2 is expressed in neural stem/progenitor cells (NPCs) and involved in the regulation of their stemness. However, it remains largely unknown about its role in the adult brain. In this study, we show that Ror2 is up-regulated in reactive astrocytes in the neocortices within 3 days following stab-wound injury. Intriguingly, Ror2-expressing astrocytes were detected primarily at the area surrounding the injury site, where astrocytes express Nestin, a marker of NPCs, and proliferate in response to injury...
October 11, 2016: Glia
https://www.readbyqxmd.com/read/27695046/role-of-dicer1-dependent-factors-in-the-paracrine-regulation-of-epididymal-gene-expression
#7
Olivia Jerczynski, Nicolas Lacroix-Pépin, Eric Boilard, Ezequiel Calvo, Agathe Bernet, Michel A Fortier, Ida Björkgren, Petra Sipilä, Clémence Belleannée
Dicer1 is an endoribonuclease involved in the biogenesis of functional molecules such as microRNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs). These small non-coding RNAs are important regulators of post-transcriptional gene expression and participate in the control of male fertility. With the knowledge that 1) Dicer1-dependent factors are required for proper sperm maturation in the epididymis, and that 2) miRNAs are potent mediators of intercellular communication in most biological systems, we investigated the role of Dicer1-dependent factors produced by the proximal epididymis (initial segment/caput)- including miRNAs- on the regulation of epididymal gene expression in the distal epididymis regions (i...
2016: PloS One
https://www.readbyqxmd.com/read/27688676/ortner-s-syndrome-cardiovocal-syndrome-caused-by-aortic-arch-pseudoaneurysm
#8
Adil H Al Kindi, Faiza A Al Kindi, Qasim S Al Abri, Nasser A Al Kemyani
72-year-old hypertensive presented with two weeks history of left sided chest pain and hoarseness. Workup demonstrated a pseudoaneurysm in the lesser curvature of the distal aortic arch opposite the origin of the left subclavian artery from a penetrating atherosclerotic ulcer. Following a left carotid-subclavian bypass, endovascular stenting of the aorta was performed excluding the pseudoaneurysm. Patient had excellent angiographic results post-stenting. Follow up at 12 weeks demonstrated complete resolution of his symptoms and good stent position with no endo-leak...
October 2016: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/27684719/potential-interest-in-circulating-mir-bart17-5p-as-a-post-treatment-biomarker-for-prediction-of-recurrence-in-epstein-barr-virus-related-nasopharyngeal-carcinoma
#9
Nobuyuki Hirai, Naohiro Wakisaka, Satoru Kondo, Mitsuharu Aga, Makiko Moriyama-Kita, Takayoshi Ueno, Yosuke Nakanishi, Kazuhira Endo, Hisashi Sugimoto, Shigeyuki Murono, Hiroshi Sato, Tomokazu Yoshizaki
OBJECTIVES: Epstein-Barr virus (EBV)-related micoRNAs (miRNAs), BamHI-A rightward transcripts (BART)-miRNAs, are released in a stable form from viable cells, which are abundant in patients with EBV-positive nasopharyngeal carcinoma (NPC). We estimated copy numbers of circulating miR-BART2-5p, miR-BART17-5p, and miR-BART18-5p as well as BamHI-W DNA as biomarkers. MATERIALS AND METHODS: Serums from 31 EBV-positive (confirmed by in situ hybridization for EBV-encoded small RNAs) NPC patients and 40 non-NPC controls were analyzed...
2016: PloS One
https://www.readbyqxmd.com/read/27680877/nuchal-skinfold-thickness-a-novel-parameter-for-assessment-of-body-composition-in-childhood-craniopharyngioma
#10
Anthe S Sterkenburg, Anika Hoffmann, Julia Reichel, Kristin Lohle, Maria Eveslage, Monika Warmuth-Metz, Hermann L Müller
CONTEXT: Hypothalamic obesity, cardiovascular disease (CVD), and relapse/progression have major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging (MRI) performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP. OBJECTIVE: Identify association of NST with body mass index (BMI), waist-to-height ratio (WHtR), functional capacity, and blood pressure (BP) in CP and controls...
September 28, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27628678/post-relapse-survival-in-patients-with-the-early-and-late-distant-recurrence-in-estrogen-receptor-positive-her2-negative-breast-cancer
#11
Akiko Ogiya, Kieko Yamazaki, Rie Horii, Tadahiko Shien, Yoshiya Horimoto, Norikazu Masuda, Touko Inao, Mitsuchika Hosoda, Naoko Ishida, Tomofumi Osako, Masato Takahashi, Yumi Endo, Yuichiro Miyoshi, Hiroyuki Yasojima, Nobumoto Tomioka, Hiroko Yamashita
BACKGROUND: Few studies have been performed on post-relapse survival in patients with the early and late distant recurrence in estrogen receptor (ER)-positive, HER2-negative breast cancer. METHODS: A total of 205 patients with the early distant recurrence and 134 patients with the late distant recurrence of ER-positive, HER2-negative breast cancer who had undergone breast surgery or neoadjuvant chemotherapy between January 2000 and December 2004 were registered from nine institutions...
September 15, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27621810/combination-treatment-with-fingolimod-and-a-pathogenic-antigen-prevents-relapse-of-glucose-6-phosphate-isomerase-peptide-induced-arthritis
#12
Yuya Yoshida, Norihisa Mikami, Yuki Matsushima, Mai Miyawaki, Hiroki Endo, Rie Banno, Takumi Tsuji, Tetsuro Fujita, Takeyuki Kohno
INTRODUCTION: Combination treatment with fingolimod (FTY720) plus pathogenic antigen is thought to prevent glucose-6-phosphate isomerase (GPI)325-339-induced arthritis progression by effective induction of immune tolerance. Here, we examined the efficacy of this combination treatment on remission maintenance. METHODS: GPI325-339-induced arthritis mice were treated for 5 days with FTY720 (1.0 mg/kg, p.o.) alone, GPI325-339 (10 μg/mouse, i.v.) alone, or with the FTY720 plus GPI325-339 combination...
September 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27613478/amelioration-of-brain-damage-by-glycine-in-neonatal-rat-brain-following-hypoxia-ischemia
#13
Hiroko Mori, Ken Momosaki, Jun Kido, Tetsuo Naramura, Kenichi Tanaka, Shirou Matsumoto, Kimitoshi Nakamura, Hiroshi Mitsubuchi, Fumio Endo, Masanori Iwai
BACKGROUND: Glycine protected adult brains against injury in an experimental model of stroke. However, because the ischemic response of neonatal brains differs from that of adult brains, we examined the neuroprotective efficacy of glycine and associated mechanisms in an experimental model of neonatal hypoxic-ischemic (HI) encephalopathy. METHODS: Neonatal (P7) Wister rats were randomly divided into an untreated group (non-HI) and two HI groups that were treated with left common carotid artery ligation and saline control or glycine...
September 10, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27611855/study-on-interactions-between-the-major-apple-valsa-canker-pathogen-valsa-mali-and-its-biocontrol-agent-saccharothrix-yanglingensis-hhs-015-using-rt-qpcr
#14
Dongying Fan, Yanfang Li, Lingyun Zhao, Zhengpeng Li, Lili Huang, Xia Yan
The mechanism of biocontrol agent Saccharothrix yanglingensis Hhs.015 action against Valsa mali, a major apple Valsa canker pathogen, was examined using a novel, sensitive (minimum detection limit 100 pg/μL) and reliably RT-qPCR technique. Prior to lesion formation, total concentration of V. mali in the bark showed a significant decrease (p<0.05) after 24 h of Hhs.015 treatment. This was more pronounced at 48 and 96 h post treatment. After lesion formation, levels of V. mali remained constant at the boundary between infected and uninfected bark tissues, although the relative expansion rate of the lesion was significantly reduced (p<0...
2016: PloS One
https://www.readbyqxmd.com/read/27592734/outcome-for-endovascular-and-open-procedures-in-infrapopliteal-lesions-for-critical-limb-ischemia-registry-based-single-center-study
#15
F Gentile, G Lundberg, R Hultgren
OBJECTIVE/BACKGROUND: To describe the risk factor distribution and outcome for patients with critical limb ischemia (CLI) due to infrapopliteal arterial lesions treated by endovascular or open procedures, with special consideration of diabetic patients. METHODS: Data were collected from the Swedish Vascular Registry, Swedvasc, covering all procedures performed on 549 consecutive patients between May 2008 and January 2014 at the Karolinska University Hospital. Diagnosis of ischemic rest pain and/or tissue loss and treatment of infrapopliteal arterial occlusive disease were considered...
September 1, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27572397/n-desmethylclozapine-fluoxetine-and-salmeterol-inhibit-post-entry-stages-of-dengue-virus-life-cycle
#16
Guruprasad R Medigeshi, Rinki Kumar, Ekta Dhamija, Tanvi Agrawal, Meenakshi Kar
Around 10,000 people die each year due to severe dengue disease and two-thirds of the world population lives in dengue endemic region. There has been remarkable progress in dengue vaccine development, however, there are no licensed antivirals for dengue disease and none appear to be in the clinical trials. We took the approach of repositioning approved drugs for anti-dengue activity by screening a library of pharmacologically active compounds. We identified N-Desmethylclozapine, Fluoxetine hydrochloride and Salmeterol xinafoate as dengue inhibitors based on reduction in the number of infected cells and viral titers...
August 29, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27569957/severe-sepsis-after-living-donor-liver-transplantation-risk-factors-and-outcomes
#17
K Takeda, Y Sawada, T Kumamoto, K Tanaka, I Endo
BACKGROUND: The post-operative mortality and morbidity rates associated with living-donor liver transplantation (LDLT) are still relatively high. Several papers have reported the risk factors associated with post-operative infectious complications, but few have analyzed the risk factors with respect to the severity of sepsis. The aim of this study was to clarify the risk factors that affect severe sepsis after LDLT. METHODS: For 63 LDLT patients at our institute, we compared peri-operative characteristics in 29 patients who developed sepsis after surgery and 34 patients who did not...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27558137/production-of-small-noncoding-rnas-from-the-flamenco-locus-is-regulated-by-the-gypsy-retrotransposon-of-drosophila-melanogaster
#18
Vincenzo Guida, Filippo M Cernilogar, Angela Filograna, Roberto De Gregorio, Hirotsugu Ishizu, Mikiko C Siomi, Gunnar Schotta, Gian Carlo Bellenchi, Davide Andrenacci
Protective mechanisms based on RNA silencing directed against the propagation of transposable elements are highly conserved in eukaryotes. The control of transposable elements is mediated by small noncoding RNAs, which derive from transposon-rich heterochromatic regions that function as small RNA-generating loci. These clusters are transcribed and the precursor transcripts are processed to generate Piwi-interacting RNAs (piRNAs) and endogenous small interfering RNAs (endo-siRNAs), which silence transposable elements in gonads and somatic tissues...
October 2016: Genetics
https://www.readbyqxmd.com/read/27484224/endothelial-dysfunction-in-resuscitated-cardiac-arrest-endo-rca-safety-and-efficacy-of-low-dose-prostacyclin-administration-and-blood-pressure-target-in-addition-to-standard-therapy-as-compared-to-standard-therapy-alone-in-post-cardiac-arrest-syndrome-patients
#19
Anna Sina P Meyer, Sisse R Ostrowski, Jesper Kjaergaard, Pär I Johansson, Christian Hassager
BACKGROUND: Morbidity and mortality following initial survival of cardiac arrest remain high despite great efforts to improve resuscitation techniques and post-resuscitation care, in part due to the ischemia-reperfusion injury secondary to the restoration of the blood circulation. Patients resuscitated from cardiac arrest display evidence of endothelial injury and coagulopathy (hypocoagulability, hyperfibrinolysis), which in associated with poor outcome. Recent randomized controlled trials have revealed that treatment with infusion of prostacyclin reduces endothelial damage after major surgery and AMI...
2016: Trials
https://www.readbyqxmd.com/read/27432717/influences-of-schneiderian-membrane-conditions-on-the-early-outcomes-of-osteotome-sinus-floor-elevation-technique-a-prospective-cohort-study-in-the-healing-period
#20
Lei Qin, Sheng-Xiao Lin, Zheng-Ze Guo, Ningbo Zhao, Ying-Liang Song, Chao Xie, De-Hua Li
OBJECTIVES: To radiographically investigate early outcomes of osteotome sinus floor elevation in the healing phase utilizing cone beam computed tomography and evaluate influences of Schneiderian membrane conditions. MATERIAL AND METHODS: One hundred patients were consecutively recruited for osteotome sinus floor elevation (OSFE) surgery using deproteinized bone mineral. CBCT was taken prior to (T0), immediately post-operatively (T1), and after the healing period (T2)...
July 18, 2016: Clinical Oral Implants Research
keyword
keyword
63307
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"