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https://www.readbyqxmd.com/read/29929197/sleep-disordered-breathing-in-children-with-rare-skeletal-disorders-a-survey-of-clinical-records
#1
Marco Zaffanello, Giorgio Piacentini, Luca Sacchetto, Angelo Pietrobelli, Emma Gasperi, Marco Barillari, Nicolò Cardobi, Luana Nosetti, Diego Ramaroli, Franco Antoniazzi
OBJECTIVE: Craniofacial disharmony in skeletal diseases is strongly associated with sleep-disordered breathing. Our aim was to study sleep respiratory patterns in young children with rare skeletal disorders. DESIGN: This retrospective study included children with achondroplasia, osteogenesis imperfecta and Ellis van Creveld Syndrome. Our subjects underwent an in-laboratory overnight respiratory polygraph between January 2012 and April 2016. All medical records were reviewed and brain Magnetic Resonance Imaging was conducted on patients with achondroplasia, nasopharynx, oropharynx and laryngopharynx spaces...
June 21, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29927795/effects-of-the-insight-obesity-preventive-intervention-on-reported-and-observed-infant-temperament
#2
Stephanie Anzman-Frasca, Ian M Paul, Kameron J Moding, Jennifer S Savage, Emily E Hohman, Leann L Birch
OBJECTIVE: Infants higher on negative reactivity and lower on regulation, aspects of temperament, have increased obesity risk. Responsive parenting (RP) has been shown to impact the expression of temperament, including the developing ability to regulate negative emotions. The aim of this analysis was to test the effects of the INSIGHT study's RP intervention designed for the primary prevention of obesity on reported and observed infant negativity and regulation. METHODS: The sample included 240 mother-infant dyads randomized 2 weeks after birth to the RP intervention or a safety control intervention...
June 20, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29924796/more-than-a-feeling-autonomous-sensory-meridian-response-asmr-is-characterized-by-reliable-changes-in-affect-and-physiology
#3
Giulia Lara Poerio, Emma Blakey, Thomas J Hostler, Theresa Veltri
Autonomous Sensory Meridian Response (ASMR) describes the experience of tingling sensations in the crown of the head, in response to a range of audio-visual triggers such as whispering, tapping, and hand movements. Public interest in ASMR has risen dramatically and ASMR experiencers watch ASMR videos to promote relaxation and sleep. Unlike ostensibly similar emotional experiences such as "aesthetic chills" from music and awe-inspiring scenarios, the psychological basis of ASMR has not yet been established...
2018: PloS One
https://www.readbyqxmd.com/read/29911610/hyperalgesia-after-experimental-and-work-related-sleep-restriction
#4
K B Nilsen, D Matrea
Aims Sleep restriction (SR) increases pain sensitivity. The aim of this study was to compare the effects of night work on pain sensitivity with experimental SR. Methods In study I 22 healthy volunteers (14 females) and in study II 24 nurses (17 females) received pain stimuli in the laboratory twice; after 2 nights with habitual sleep (study I and II) and after 2 nights of experimental 50% SR (study I) or after 2 nights of work (study II). Order of sleep conditions was randomized. Heat pain at intensity 6/10 (pain-6), the pressure pain threshold (PPT), and subjective sleepiness with Karolinska sleepiness scale (KSS) were assessed...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29880147/the-scope-of-sleep-problems-in-canadian-children-and-adolescents-with-obesity
#5
Joanna E MacLean, Kristie DeHaan, Tamya Chowdhury, Joy Nehme, Glenda N Bendiak, Lynda Hoey, Linda Horwood, Hans Pasterkamp, Valerie Kirk, Evelyn Constantin, Sherri L Katz
OBJECTIVE: To determine the scope of sleep concerns, clinical features, and polysomnography (PSG) results and to identify factors that predict obstructive sleep apnea (OSA) in a cohort of children with obesity. METHODS: The study was a multicenter retrospective chart review. Data were collected from three pediatric sleep laboratories over a two year period for all children of age 8-16 years with a body mass index [BMI] ≥95th centile who were undergoing PSG. Data sources included clinical charts and PSG results...
July 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29868772/brain-bioenergetics-during-resting-wakefulness-are-related-to-neurobehavioural-deficits-in-severe-obstructive-sleep-apnea-a-31p-magnetic-resonance-spectroscopy-study
#6
Angela L D'Rozario, Delwyn J Bartlett, Keith K H Wong, Toos Sach, Qiao Yang, Ronald R Grunstein, Caroline D Rae
Study Objectives: Obstructive sleep apnea (OSA) is a well-established cause of impaired daytime functioning. However, there is a complex inter-individual variability in neurobehavioural performance in OSA patients. We previously reported compromised brain bioenergetics during apneic sleep in severe OSA. In this study, we investigate whether brain bioenergetics during resting wakefulness are related to neurobehavioural performance. Methods: Patients attended the sleep laboratory in the evening and were kept awake over-night...
June 1, 2018: Sleep
https://www.readbyqxmd.com/read/29868143/central-sleep-apnea-a-rare-cause-for-acute-respiratory-insufficiency-in-children-case-report
#7
Nicoleta Aurelia Popescu, Marcela Daniela Ionescu, Georgiana Balan, Simina Visan, Eliza Cinteza, Diana Stanescu, Ionut Gobej, Mihaela Balgradean
Central sleep apnea is characterized by frequent cessation of breathing during sleep, resulting in repetitive episodes of insufficient ventilation and abnormalities of acid-base balance. It may be primary or secondary, and it is uncommon in children, with limited data for this population. We present here the case of a five-year-old girl, known to have thoracolumbar myelomeningocele (for which she underwent a surgical procedure in infancy), secondary hydrocephalus (with a ventriculoperitoneal shunt) and flaccid paralysis, who was admitted in our hospital with prolonged fever syndrome, productive cough, severe dyspnea and perioral cyanosis...
March 2018: Mædica
https://www.readbyqxmd.com/read/29867419/in-home-sleep-recordings-in-military-veterans-with-posttraumatic-stress-disorder-reveal-less-rem-and-deep-sleep-1-hz
#8
Julie A Onton, Scott C Matthews, Dae Y Kang, Todd P Coleman
Veterans with posttraumatic stress disorder (PTSD) often report suboptimal sleep quality, often described as lack of restfulness for unknown reasons. These experiences are sometimes difficult to objectively quantify in sleep lab assessments. Here, we used a streamlined sleep assessment tool to record in-home 2-channel electroencephalogram (EEG) with concurrent collection of electrodermal activity (EDA) and acceleration. Data from a single forehead channel were transformed into a whole-night spectrogram, and sleep stages were classified using a fully automated algorithm...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29866861/model-system-identifies-kinetic-driver-of-hsp90-inhibitor-activity-against-african-trypanosomes-and-plasmodium-falciparum
#9
Kirsten J Meyer, Emily Caton, Theresa A Shapiro
Hsp90 inhibitors, well-studied in the laboratory and clinic for antitumor indications, have promising activity against protozoan pathogens, including Trypanosoma brucei that causes African sleeping sickness, and malaria parasite Plasmodium falciparum To progress these experimental drugs toward clinical use we adapted an in vitro dynamic hollow-fiber system and deployed artificial pharmacokinetics to discover the driver of their activity: either concentration or time. Compounds from three major classes of Hsp90 inhibitors in development were evaluated against trypanosomes...
June 4, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29865870/from-nanowarming-to-thermoregulation-new-multiscale-applications-of-bioheat-transfer
#10
John C Bischof, Kenneth R Diller
This review explores bioheat transfer applications at multiple scales from nanoparticle (NP) heating to whole-body thermoregulation. For instance, iron oxide nanoparticles are being used for nanowarming, which uniformly and quickly rewarms 50-80-mL (≤5-cm-diameter) vitrified systems by coupling with radio-frequency (RF) fields where standard convective warming fails. A modification of this approach can also be used to successfully rewarm cryopreserved fish embryos (∼0.8 mm diameter) by heating previously injected gold nanoparticles with millisecond pulsed laser irradiation where standard convective warming fails...
June 4, 2018: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/29863387/influence-of-tiagabine-maintenance-on-cannabis-effects-and-related-behaviors-in-daily-cannabis-users
#11
Michael J Wesley, Philip M Westgate, William W Stoops, Thomas H Kelly, Lon R Hays, Joshua A Lile
No medications are approved for cannabis use disorder (CUD). Gamma-aminobutyric acid (GABA) reuptake is modulated by cannabinoid (CB) receptor agonists, and there are shared effects between CB agonists and the GABA reuptake inhibitor tiagabine. This overlapping neuropharmacology suggested that tiagabine might be useful for CUD. The study determined the ability of tiagabine maintenance to reduce cannabis self-administration using a placebo-controlled, double-blind, counterbalanced, within-subjects design. Nontreatment-seeking daily cannabis users (N = 12; 3 female, 9 male) completed two 12-day outpatient maintenance phases (0 or 12 mg of tiagabine/day)...
June 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29862620/differential-effects-of-the-circadian-system-and-circadian-misalignment-on-insulin-sensitivity-and-insulin-secretion-in-humans
#12
Jingyi Qian, Chiara Dalla Man, Christopher J Morris, Claudio Cobelli, Frank Ajl Scheer
Glucose tolerance is lower at night and higher in the morning. Shift workers, who often eat at night and experience circadian misalignment (i.e., misalignment between the central circadian pacemaker and the environmental/behavioral cycle), have an increased risk of type 2 diabetes. To determine the separate and relative impacts of the circadian system, behavioral/environmental cycles, and their interaction (i.e., circadian misalignment) on insulin sensitivity and β-cell function, we used the oral minimal model to quantitatively assess the major determinants of glucose control in 14 healthy adults, using a randomized, cross-over design with two 8-day laboratory protocols...
June 4, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29860437/the-bidirectional-association-between-physical-activity-and-sleep-in-middle-aged-and-older-adults-a-prospective-study-based-on-polysomnography
#13
Arthur E Mesas, Erika W Hagen, Paul E Peppard
Study objectives: To examine the bidirectional association between physical activity (PA) and polysomnographically (PSG)-assessed sleep parameters characterized by total sleep time (TST), sleep onset latency (SOL), wake time after sleep onset (WASO), sleep efficiency and percentage of TST in N1, N2 and N3 stages and REM sleep in middle-aged and older adults. Methods: Longitudinal study based on a subsample of the Wisconsin Sleep Cohort. Self-reported PA information was used to estimate the MET-min/week activity and in-laboratory PSG exams provided information on sleep parameters at baseline and after 3-11 years of follow-up between 2004 and 2015...
May 31, 2018: Sleep
https://www.readbyqxmd.com/read/29851515/chronic-effects-of-neurotrauma-consortium-cenc-multicentre-study-interim-analysis-differences-between-participants-with-positive-versus-negative-mild-tbi-histories
#14
William C Walker, Shawn Hirsch, William Carne, Tracy Nolen, David X Cifu, Elisabeth A Wilde, Harvey S Levin, Timothy W Brearly, Blessen C Eapen, Rick Williams
OBJECTIVES: Compare characteristics and outcomes of combat-exposed military personnel with positive versus negative mild traumatic brain injury (mTBI) histories. SETTING: Recruitment was from registration lists and ambulatory clinics at four veterans administration hospitals. PARTICIPANTS: Consented veterans and service members completing initial evaluation by September 2016 (n = 492). DESIGN: Observational with cross-sectional analyses...
May 31, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29847582/screening-for-obstructive-sleep-apnea-among-hospital-outpatients
#15
Michel Hug, Katrin Uehli, Stig Solbach, Stefanie Brighenti-Zogg, Selina Dürr, Sabrina Maier, Jörg Daniel Leuppi, David Miedinger
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is common in adults. People with OSAS have a higher risk of experiencing traffic accidents and occupational injuries (OIs). We aimed to clarify the diagnostic performance of a three-channel screening device (ApneaLinkTM) compared with the gold standard of full-night attended polysomnography (PSG) among hospital outpatients not referred for sleep-related symptoms. Furthermore, we aimed to determine whether manual revision of the ApneaLinkTM autoscore enhanced diagnostic performance...
2018: PloS One
https://www.readbyqxmd.com/read/29807554/effects-of-slow-wave-activity-on-mood-disturbance-in-major-depressive-disorder
#16
Jennifer R Goldschmied, Philip Cheng, Robert Hoffmann, Elaine M Boland, Patricia J Deldin, Roseanne Armitage
BACKGROUND: Studies have demonstrated that decreases in slow-wave activity (SWA) predict decreases in depressive symptoms in those with major depressive disorder (MDD), suggesting that there may be a link between SWA and mood. The aim of the present study was to determine if the consequent change in SWA regulation following a mild homeostatic sleep challenge would predict mood disturbance. METHODS: Thirty-seven depressed and fifty-nine healthy adults spent three consecutive nights in the sleep laboratory...
May 29, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29804145/residual-renal-function-affects-severity-of-sleep-apnea-in-peritoneal-dialysis-a-pilot-study
#17
Aviya Lanis, Eric Kerns, Susie L Hu, Margaret H Bublitz, Patricia Risica, Susan Martin, Jeffrey Parker, Richard Millman, Lance D Dworkin, Ghada Bourjeily
PURPOSE: Obstructive sleep apnea is common in patients with end-stage renal disease, and there is increasing evidence that clinical factors specific to end-stage renal disease contribute pathophysiologically to obstructive sleep apnea. It is not known whether circumstances specific to dialysis modality, in this case peritoneal dialysis, affect obstructive sleep apnea. Our study aimed to investigate the prevalence of obstructive sleep apnea in the peritoneal dialysis population and the relevance of dialysis-specific measures and kidney function in assessing this bidirectional relationship...
May 26, 2018: Lung
https://www.readbyqxmd.com/read/29798125/-relationship-of-symptoms-with-sleep-stage-abnormalities-in-obstructive-sleep-apnea-hypopnea-syndrome
#18
H J Liu, N Zhao, A F Zhang
Objective: To study the relationship between symptoms and sleep staging in OSAHS patients. Method: A cross-sectional study. Adult subjects who attended a sleep laboratory for diagnostic polysomnography for a period of 1 month were recruited consecutively.OSAHS was diagnosed using American Academy of Sleep Medicine criteria.Subjects filled a questionnaire for symptoms prior to polysomnography. Result: Thirty subjects, of whom 83.3% were obese, met diagnostic criteria, with males constituting 46.7% and females constituting 53%...
November 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29797127/polymorphism-of-oprm1-gene-and-its-association-with-manifestations-of-n-1-phenethyl-4-piperidyl-propionanilide-intoxication-in-rats
#19
O V Varlamova, A V Babkin, I S Berdinskikh, G V Nazarov, A S Nikiforov, V N Bykov, M B Ivanov
We studied association of Oprm1 gene polymorphisms with signs of N-(1-phenethyl-4-piperidyl)propionanilide intoxication in rats. It was found that the rate of intoxication in laboratory animals depends on genetic features. A polymorphic variant rs105312806 of Oprm1 gene can be a possible marker of animal sensitivity to opioid receptor agonists. This hypothesis was supported by differences in the rats of intoxication signs such as time to lateral posture and sleep duration in homozygous rats carrying different alleles...
May 24, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29796194/ambulatory-positional-obstructive-sleep-apnea-syndrome
#20
Fernando Di-Tullio, Glenda Ernst, Gabriela Robaina, Magali Blanco, Alejandro Salvado, Ana Meraldi, Martin Bosio, Eduardo Borsini
Objective: To establish the prevalence of positional (PP) OSA patients using self-administered home-based respiratory polygraphy (RP). Materials and Methods: 52 month retrospective study based on RP records. Results: 200 PR records: 70.5% men 29.5% women. 76% were diagnosed with OSA and 54.6% with PP OSA. There were no significant differences in Epworth Sleepiness Scale, apnea hypopnea index and oxygen desaturation index. PP OSA patients were younger, had a lower BMI (30...
January 2018: Sleep Science
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