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https://www.readbyqxmd.com/read/28212067/the-treatment-of-severe-childhood-aggression-study-12-weeks-of-extended-blinded-treatment-in-clinical-responders
#1
Robert L Findling, Lisa Townsend, Nicole V Brown, L Eugene Arnold, Kenneth D Gadow, David J Kolko, Nora K McNamara, Devin S Gary, Dana B Kaplin, Cristan A Farmer, Heidi Kipp, Craig Williams, Eric M Butter, Oscar G Bukstein, Robert Rice, Kristin Buchan-Page, Brooke S G Molina, Michael G Aman
OBJECTIVES: Previous "Treatment of Severe Childhood Aggression" (TOSCA) reports demonstrated that many children with severe physical aggression and attention-deficit/hyperactivity disorder (ADHD) responded well to two randomized treatments (parent training [PT]+stimulant+placebo = Basic vs. PT+stimulant+risperidone = Augmented) for 9 weeks. An important clinical question is whether these favorable outcomes are maintained over longer times. METHODS: Clinical responders to the 9-week trial (n = 103/168), defined as Clinical Global Impressions (CGI)-Improvement of much/very much improved plus substantial reduction in parent ratings of disruptiveness, were followed another 12 weeks (21 weeks total) while remaining on blinded treatment...
February 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28198530/location-of-the-narrowest-area-of-the-pharynx-regarding-bmi-and-osa-severity
#2
Marta Krasny, Jarosław Wysocki, Monika Prus, Kazimierz Niemczyk
BACKGROUND: Among authors studying morphological determinants of the Obstructive Sleep Apnoea (OSA) controversies exist on the location of the narrowest area within the pharynx critical for development of obstruction. Those disagreements primarily revolve around differences between obese and nonobese OSA patients. Determination whether the location and size of the narrowest area within the pharynx differentiates the obese and nonobese OSA patients. MATERIALS AND METHODS: A population of 55 subjects was investigated after being diagnosed with OSA in the Polysomnography Laboratory of the Department and Clinic of Otolaryngology in the Medical University of Warsaw...
February 15, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28197218/polysomnographic-findings-in-infants-with-pierre-robin-sequence
#3
Abdullah Khayat, Saadoun Bin-Hassan, Suhail Al-Saleh
INTRODUCTION: Pierre Robin sequence (PRS) is characterized by the triad of micrognathia, glossoptosis, and upper airway obstruction. It is commonly associated with the secondary cleft palate. Infants with PRS commonly have sleep-disordered breathing (SDB); including obstructive sleep apnea (OSA) as well as central sleep breathing abnormalities that are present from infancy. AIM OF THE STUDY: Evaluate the prevalence and severity of SDB in infants with PRS using polysomnography (PSG)...
January 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28196342/decreased-salivary-alpha-amylase-levels-are-associated-with-performance-deficits-during-sleep-loss
#4
Maja Pajcin, Siobhan Banks, Jason M White, Jill Dorrian, Gemma M Paech, Crystal Grant, Kayla Johnson, Katie Tooley, Justin Fidock, Gary H Kamimori, Chris B Della Vedova
During sleep deprivation, neurobehavioral functions requiring sustained levels of attention and alertness are significantly impaired. Discrepancies between subjective measures of sleepiness and objective performance during sustained operations have led to interest in physiological monitoring of operator performance. Alertness, vigilance, and arousal are modulated by the wake-promoting actions of the central noradrenergic system. Salivary alpha-amylase (sAA) has been proposed as a sensitive peripheral measure of noradrenergic activity, but limited research has investigated the relationship between sAA and performance...
February 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28186930/protective-factors-for-child-development-at-age-2-in-the-presence-of-poor-maternal-mental-health-results-from-the-all-our-babies-aob-pregnancy-cohort
#5
Sheila W McDonald, Heather L Kehler, Suzanne C Tough
OBJECTIVE: To identify the combination of factors most protective of developmental delay at age 2 among children exposed to poor maternal mental health. DESIGN: Observational cohort study. SETTING: Pregnant women were recruited from primary healthcare offices, the public health laboratory service and community posters in Calgary, Alberta, Canada. PARTICIPANTS: 1596 mother-child dyads who participated in the All Our Babies study and who completed a follow-up questionnaire when their child was 2 years old...
November 10, 2016: BMJ Open
https://www.readbyqxmd.com/read/28186393/chronic-fatigue-in-ehlers-danlos-syndrome-hypermobile-type
#6
Alan Hakim, Inge De Wandele, Chris O'Callaghan, Alan Pocinki, Peter Rowe
Chronic fatigue is an important contributor to impaired health-related quality of life in Ehlers-Danlos syndrome. There is overlap in the symptoms and findings of EDS and chronic fatigue syndrome. A proportion of those with CFS likely have EDS that has not been identified. The evaluation of chronic fatigue in EDS needs to include a careful clinical examination and laboratory testing to exclude common causes of fatigue including anemia, hypothyroidisim, and chronic infection, as well as dysfunction of major physiological or organ systems...
February 10, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28183231/autonomic-nervous-activities-associated-with-bruxism-events-during-sleep
#7
Shinichi Nukazawa, Hidehiro Yoshimi, Sadao Sato
OBJECTIVES: To confirm the relationship between sleep bruxism (SB) and autonomic nervous (AN) activities to elucidate SB physiology. METHODS: Subjects included 11 healthy males (mean age, 24.7 ± 2.3 years). These data were recorded in the sleep laboratory using a system composed of a two-axis accelerometer, an infrared camera, electroencephalography, electromyography, and electrocardiography. Time lapse analysis confirmed correlations between AN activity and SB events during sleep in subjects...
February 10, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28177332/a-comparative-study-on-oxidative-stress-role-in-nasal-breathing-impairment-and-obstructive-sleep-apnoea-syndrome
#8
D Passali, G Corallo, A Petti, M Longini, F M Passali, G Buonocore, L M Bellussi
Obstructive sleep apnoea syndrome (OSAS) is a sleep disorder that leads to metabolic abnormalities and increased cardiovascular risk. This study aimed to define the expression and clinical significance of biomarkers involved in oxidative stress in patients with OSAS. A prospective study was designed to compare outcomes of oxidative stress laboratory tests in three groups of subjects. The study involved the recruitment of three groups of subjects, 10 patients with obstructive sleep apnoea syndrome with AHI > 30; 10 patients suffering from snoring at night with AHI < 15; 10 patients with nasal respiratory impairment with AHI < 5...
December 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28176621/a-review-of-the-physiological-factors-associated-with-alcohol-hangover
#9
Celeste Tipple, Sarah Michelle Benson, Andrew Scholey
Alcohol hangovers are a commonly experienced consequence of drinking and are frequently associated with worsened mood and cognitive functioning. The physiological changes that occur with an alcohol-induced hangover state are largely unknown. This review focuses on key physiological factors of an alcohol-induced hangover, more specifically, oxidative stress, lack of sleep, hormonal fluctuations, dehydration, headaches, fever and changes to the immune system. Increased understanding of the relationship between the physiological factors and symptoms of a hangover is needed to further elucidate the mechanisms of an alcohol-induced hangover and potentially identify a treatment...
February 7, 2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/28169045/sleep-surgery-tool-a-medical-checklist-to-review-prior-to-operating
#10
Macario Camacho, Robert W Riley, Robson Capasso, Peter O'Connor, Edward T Chang, Lauren K Reckley, Christian Guilleminault
OBJECTIVE: The objective of this study was to systematically review the international literature for studies providing a preoperative checklist for medical disorders to be evaluated or treated before performing sleep surgery. If no checklist exists, then studies providing recommendations would be used to develop a checklist de novo. STUDY DESIGN: Systematic review combined with expert opinion. METHODS: Four databases, including PubMed/Medline were searched through August 10, 2016...
January 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28167012/comparison-of-diagnostic-reliability-of-out-of-center-sleep-tests-for-obstructive-sleep-apnea-between-adults-and-children
#11
Masaaki Suzuki, Taiji Furukawa, Akira Sugimoto, Ryosuke Kotani, Rika Hosogaya
OBJECTIVES: Sleep studies for diagnosing obstructive sleep apnea (OSA) in children are laborious, expensive, inconvenient, and often not readily available. Out-of-center sleep test (OCST) devices have been studied for diagnosing OSA in adults, but few OCST studies have been done in children. The purpose of this study was to clarify the diagnostic reliability of OCST devices for children. METHODS: OCSTs using pulse oximetry and in-laboratory polysomnography (PSG) were performed separately in 686 adults and 119 children...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28165489/the-interrelated-effect-of-sleep-and-learning-in-dogs-canis-familiaris-an-eeg-and-behavioural-study
#12
Anna Kis, Sára Szakadát, Márta Gácsi, Enikő Kovács, Péter Simor, Csenge Török, Ferenc Gombos, Róbert Bódizs, József Topál
The active role of sleep in memory consolidation is still debated, and due to a large between-species variation, the investigation of a wide range of different animal species (besides humans and laboratory rodents) is necessary. The present study applied a fully non-invasive methodology to study sleep and memory in domestic dogs, a species proven to be a good model of human awake behaviours. Polysomnography recordings performed following a command learning task provide evidence that learning has an effect on dogs' sleep EEG spectrum...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28162146/validity-of-actigraphy-in-measurement-of-sleep-in-young-adults-with-type-1-diabetes
#13
Sarah S Farabi, Lauretta Quinn, David W Carley
STUDY OBJECTIVES: Accurate objective measurement of sleep, an important health behavior, is needed. Individuals with type 1 diabetes mellitus (T1DM) have altered sleep architecture and reduced sleep quality in comparison with healthy controls. The aim of this investigation was to compare a commonly used actigraphy device, Actiwatch2, with polysomnography (PSG)-based measures of sleep in young adults with T1DM, and to determine which Actiwatch2 threshold setting provides the best correspondence...
January 31, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28159193/screening-for-obstructive-sleep-apnea-in-the-assessment-of-coronary-risk
#14
Yan-Yi Cheung, Bee-Choo Tai, Germaine Loo, See-Meng Khoo, Karen Yin-Phoon Cheong, Ferran Barbe, Chi-Hang Lee
There is increasing awareness that health screening may prevent some acute coronary events. Yet, obstructive sleep apnea (OSA) is seldom screened for and its relation with coronary risk markers is not well established. Consecutive adults (n = 696) enrolled in a cardiovascular health screening program were approached to determine the feasibility of incorporating OSA screening. Screening included questionnaires and a home-based sleep study. High-sensitivity C-reactive protein was the primary coronary risk marker, and other laboratory- and exercise treadmill-based markers were also reported...
January 5, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28159092/impact-of-portable-sleep-testing
#15
REVIEW
Vaishnavi Kundel, Neomi Shah
This article provides the current state of evidence on the socioeconomic impact of portable testing (PT) for sleep apnea. It seems the traditional in-laboratory polysomnography and the newer home-based PT model for sleep apnea diagnosis both have places in sleep medicine diagnostic algorithm. PT would be cost-effective in a selected group of patients as long as certain criteria, discussed in this article, are carefully considered.
March 2017: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/28156441/strategy-of-using-herbal-extract-preparations-for-stage-iv-cancer-in-palliative-care-an-enhanced-and-maintenance-therapy
#16
Zhang Lingyan, Zhou Xiaoxia, Yin Weihua, Zhang Xiulian, Liu Hong, Duan Xiaopeng, Yu Cui, Luo Xiaolu, Zhong Qingfeng, Zhao Fen, Li Xianyong
: 89 Background: Palliative care is focused and seems as rationally anti-cancer way that have low systemic toxicity and acceptable effectiveness for stage IV cancer, especially herbal extracted medicines, which can regulate tumor microenviroment and body immune system. Our previous lab studies have indicated that TGF-beta, EGF, VEGF, IL-10 cytokines expression and mico-vessel density can be downgraded in tumor microenviroment by herbal extract preparation from Ginseng, Herba Agrimonia, Hairyvein and Arginine etc...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156435/sleep-quality-among-inpatients-with-acute-myeloid-leukemia
#17
Kelli Aibel, Ryan Meyerhoff, David Harpole, Amy Pickar Abernethy, Chi-Fu Jeffrey Yang
: 82 Background: Anecdotally, sleep is thought to be a significant problem for inpatients receiving treatment for acute myeloid leukemia (AML), butsleep disturbances in this setting are not well-characterized. We aimed to assess the feasibility of measuring sleep in AML patients using a wearable actigraphy device. METHODS: Using the Actigraph GT3X "watch,"we assessed the total sleep time, sleep onset latency, wake after sleep onset, number of awakenings after sleep onset, and sleep efficiency for inpatients with AML receiving induction chemotherapy during their hospitalization...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28155104/estimating-sleep-time-from-non-eeg-based-psg-signals-in-the-diagnosis-of-sleep-disordered-breathing
#18
M B Norman, C E Sullivan
PURPOSE: The purpose of this study was to use non-EEG PSG signals to estimate TST in order to diagnose SDB with a greater sensitivity than type 3 device methodology that relies on TRT. METHODS: Movement patterns were obtained from the thoracoabdominal signals of adult PSG recordings (n = 60) in the laboratory and the home. Parameters obtained allowed, with 95% certainty, identification of sleep and wake based on the duration of movements and quiescent time (Qd)...
February 3, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28151944/diurnal-variation-and-twenty-four-hour-sleep-deprivation-do-not-alter-supine-heart-rate-variability-in-healthy-male-young-adults
#19
Daniel S Quintana, Torbjørn Elvsåshagen, Nathalia Zak, Linn B Norbom, Per Ø Pedersen, Sophia H Quraishi, Atle Bjørnerud, Ulrik F Malt, Inge R Groote, Tobias Kaufmann, Ole A Andreassen, Lars T Westlye
Heart rate variability (HRV) has become an increasingly popular index of cardiac autonomic control in the biobehavioral sciences due to its relationship with mental illness and cognitive traits. However, the intraindividual stability of HRV in response to sleep and diurnal disturbances, which are commonly reported in mental illness, and its relationship with executive function are not well understood. Here, in 40 healthy adult males we calculated high frequency HRV-an index of parasympathetic nervous system (PNS) activity-using pulse oximetry during brain imaging, and assessed attentional and executive function performance in a subsequent behavioral test session at three time points: morning, evening, and the following morning...
2017: PloS One
https://www.readbyqxmd.com/read/28151835/predictors-of-the-transition-from-acute-to-persistent-musculoskeletal-pain-in-children-and-adolescents-a-prospective-study
#20
Amy Lewandowski Holley, Anna C Wilson, Tonya M Palermo
Strategies directed at the prevention of disabling pain have been suggested as a public health priority, making early identification of youth at risk for poor outcomes critical. At present, limited information is available to predict which youth presenting with acute pain are at risk for persistence. The aims of this prospective longitudinal study were to identify biopsychosocial factors in the acute period that predict the transition to persistent pain in youth with new-onset musculoskeletal (MSK) pain complaints...
December 22, 2016: Pain
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