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https://www.readbyqxmd.com/read/27905903/immediate-effect-of-cpap-titration-on-perceived-health-related-quality-of-life-a-prospective-observational-study
#1
Serena Iacono Isidoro, Adriana Salvaggio, Anna Lo Bue, Salvatore Romano, Oreste Marrone, Giuseppe Insalaco
BACKGROUND: Perceived Health Related Quality of Life (HRQoL) is impaired in obstructive sleep apnea (OSA). This study examines changes in HRQoL aspects occurring immediately after CPAP titration. Furthermore, we analyzed variations in each gender and in patients undergoing home or laboratory-based CPAP titration pathways. METHODS: Twohundredfive outpatients (151 M) (56.7 ± 10.3 years) were evaluated, before first visit and nocturnal diagnostic examination (T0), and the morning after CPAP titration (T1)...
December 1, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27904735/urinary-metabolomics-of-young-italian-autistic-children-supports-abnormal-tryptophan-and-purine-metabolism
#2
Federica Gevi, Lello Zolla, Stefano Gabriele, Antonio M Persico
BACKGROUND: Autism spectrum disorder (ASD) is still diagnosed through behavioral observation, due to a lack of laboratory biomarkers, which could greatly aid clinicians in providing earlier and more reliable diagnoses. Metabolomics on human biofluids provides a sensitive tool to identify metabolite profiles potentially usable as biomarkers for ASD. Initial metabolomic studies, analyzing urines and plasma of ASD and control individuals, suggested that autistic patients may share some metabolic abnormalities, despite several inconsistencies stemming from differences in technology, ethnicity, age range, and definition of "control" status...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27904630/a-survey-of-the-therapeutic-effects-of-vitamin-e-suppositories-on-vaginal-atrophy-in-postmenopausal-women
#3
Aazam Parnan Emamverdikhan, Nahid Golmakani, Sayyed ASajadi Tabassi, Malihe Hassanzadeh, Nooriyeh Sharifi, Mohammad Taghi Shakeri
BACKGROUND: Menopause is associated with various complications such as depression, sleep disorders, and genitourinary atrophy. Vaginal atrophy occurs due to the loss of steroid hormones, and its major symptoms include vaginal dryness, itching, dyspareunia, and bleeding after intercourse. According to the literature, vitamin E plays a key role in estrogen stability. The aim of this study was to compare the effects of vitamin E suppositories and conjugated estrogen vaginal cream on vaginal atrophy...
September 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/27904509/a-new-diagnostic-tool-for-masked-hypertension-impaired-sleep-quality
#4
Fatma Erdem, Ugur Cakır, Osman Yıldırım, Aytekin Alcelik, Ibrahim Donmez, Taha Can Tuman, Sabri Onur Caglar, Alim Erdem, Mehmet Yazıcı
INTRODUCTION: The aim of this study was to evaluate the relationship between masked hypertension and impaired sleep quality. Additionally, we evaluated the diagnostic role and prevalence of poor sleep quality among patients with newly diagnosed masked hypertension. MATERIAL AND METHODS: A total of 112 individuals, 72 patients with newly diagnosed masked hypertension and 40 normotensive healthy volunteers, were included in this study. All patients underwent evaluation comprising 12-lead electrocardiography, transthoracic echocardiography, 24-hour Holter ECG, and basic laboratory tests...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27900657/the-sawtooth-sign-is-predictive-of-obstructive-sleep-apnea
#5
Michael H Bourne, Paul D Scanlon, Darrell R Schroeder, Eric J Olson
BACKGROUND: The sawtooth sign in spirometry is associated with redundant upper airway tissue and snoring, but its predictive value for identifying obstructive sleep apnea (OSA) is disputed. We retrospectively assessed the predictive value of the spirometric sawtooth sign in terms of the odds ratio (OR) of association with a diagnosis of OSA compared to those without the sign. METHODS: Consecutive spirometry reports showing a sawtooth sign were identified from our laboratory...
November 29, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27900260/gut-microbiota-and-glucometabolic-alterations-in-response-to-recurrent-partial-sleep-deprivation-in-normal-weight-young-individuals
#6
Christian Benedict, Heike Vogel, Wenke Jonas, Anni Woting, Michael Blaut, Annette Schürmann, Jonathan Cedernaes
OBJECTIVE: Changes to the microbial community in the human gut have been proposed to promote metabolic disturbances that also occur after short periods of sleep loss (including insulin resistance). However, whether sleep loss affects the gut microbiota remains unknown. METHODS: In a randomized within-subject crossover study utilizing a standardized in-lab protocol (with fixed meal times and exercise schedules), we studied nine normal-weight men at two occasions: after two nights of partial sleep deprivation (PSD; sleep opportunity 02:45-07:00 h), and after two nights of normal sleep (NS; sleep opportunity 22:30-07:00 h)...
December 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27899291/dynamic-changes-in-sleep-pattern-during-post-partum-in-normal-pregnancy-in-rat-model
#7
Neelima Sivadas, Arathi Radhakrishnan, B S Aswathy, Velayudhan Mohan Kumar, Kamalesh K Gulia
To develop an animal model for studies on peri-partum sleep disorders, sleep patterns in female Wistar rats during pregnancy, post-partum and after weaning, were assessed and associated adaptive changes in their anxiety were examined. Adult nulliparous female rats, maintained in standard laboratory conditions with ad libitum food and water, were surgically implanted with electroencephalogram and electromyogram electrodes under anaesthesia for objective assessment of sleep-wakefulness (S-W). After post-surgical recovery, three control recordings of S-W were taken for 24h before the animals were kept for mating...
November 26, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27898693/a-comparison-between-temperature-controlled-laminar-airflow-device-and-a-room-air-cleaner-in-reducing-exposure-to-particles-while-asleep
#8
Michal P Spilak, Torben Sigsgaard, Hisamitsu Takai, Guoqiang Zhang
People spend approximately one third of their life sleeping. Exposure to pollutants in the sleep environment often leads to a variety of adverse health effects, such as development and exacerbation of asthma. Avoiding exposure to these pollutants by providing a sufficient air quality in the sleep environment might be a feasible method to alleviate these health symptoms. We performed full-scale laboratory measurements using a thermal manikin positioned on an experimental bed. Three ventilation settings were tested: with no filtration system operated, use of portable air cleaner and use of a temperature-controlled laminar airflow (TLA) device...
2016: PloS One
https://www.readbyqxmd.com/read/27896179/clinical-factors-associated-with-the-non-operative-airway-management-of-patients-with-robin-sequence
#9
Frank P Albino, Benjamin C Wood, Kevin D Han, Sojung Yi, Mitchel Seruya, Gary F Rogers, Albert K Oh
BACKGROUND: The indications for surgical airway management in patients with Robin sequence (RS) and severe airway obstruction have not been well defined. While certain patients with RS clearly require surgical airway intervention and other patients just as clearly can be managed with conservative measures alone, a significant proportion of patients with RS present with a more confusing and ambiguous clinical course. The purpose of this study was to describe the clinical features and objective findings of patients with RS whose airways were successfully managed without surgical intervention...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27894543/relationship-between-head-posture-and-the-severity-of-obstructive-sleep-apnea
#10
Oral Sökücü, Rıdvan Okşayan, Meral Uyar, Kadriye Ebru Ademci, Serdar Üşümez
INTRODUCTION: The objective of this study was to compare the head posture of patients with obstructive sleep apnea (OSA) having different levels of severity with that of control subjects. METHODS: One hundred subjects participated in this study. Seventy-five subjects underwent overnight polysomnography in a sleep laboratory and were allocated into "mild," "moderate," or "severe" OSA groups, and 25 subjects with no complaints regarding OSA were allocated into 1 group and served as the controls...
December 2016: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27888574/normal-heart-in-parkinson-s-disease-is-this-a-distinct-clinical-phenotype
#11
J-S Kim, H-E Park, I-S Park, Y-S Oh, D-W Ryu, I-U Song, Y-A Jung, I R Yoo, H-S Choi, P H Lee, K-S Lee
BACKGROUND AND PURPOSE: Reduction of metaiodobenzylguanidine (MIBG) uptake has been observed in almost all patients with Parkinson's disease (PD), associated with hyposmia, orthostatic hypotension and rapid eye movement sleep behavioral disorder (RBD). In contrast, a subgroup of patients with PD with normal MIBG uptake have been reported to have milder disease and preserved cognition compared with those with lower MIBG. The aim of this study was to investigate whether non-motor manifestations of PD differ between patients with normal and abnormal myocardial MIBG uptake...
November 26, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27878543/a-new-predictive-model-for-continuous-positive-airway-pressure-in-the-treatment-of-obstructive-sleep-apnea
#12
Matthew R Ebben, Mariya Narizhnaya, Ana C Krieger
BACKGROUND: Numerous mathematical formulas have been developed to determine continuous positive airway pressure (CPAP) without an in-laboratory titration study. Recent studies have shown that style of CPAP mask can affect the optimal pressure requirement. However, none of the current models take mask style into account. Therefore, the goal of this study was to develop new predictive models of CPAP that take into account the style of mask interface. METHODS: Data from 200 subjects with attended CPAP titrations during overnight polysomnograms using nasal masks and 132 subjects using oronasal masks were randomized and split into either a model development or validation group...
November 22, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27868362/testing-sleep-consolidation-in-skill-learning-a-field-study-using-an-online-game
#13
Tom Stafford, Erwin Haasnoot
Using an observational sample of players of a simple online game (n > 1.2 million), we are able to trace the development of skill in that game. Information on playing time, and player location, allows us to estimate time of day during which practice took place. We compare those whose breaks in practice probably contained a night's sleep and those whose breaks in practice probably did not contain a night's sleep. Our analysis confirms experimental evidence showing a benefit of spacing for skill learning, but it fails to find any additional benefit of sleeping during a break from practice...
November 20, 2016: Topics in Cognitive Science
https://www.readbyqxmd.com/read/27868260/an-experimental-study-of-adolescent-sleep-restriction-during-a-simulated-school-week-changes-in-phase-sleep-staging-performance-and-sleepiness
#14
Alex Agostini, Mary A Carskadon, Jillian Dorrian, Scott Coussens, Michelle A Short
This laboratory study investigated the impact of restricted sleep during a simulated school week on circadian phase, sleep stages and daytime functioning. Changes were examined across and within days and during a simulated weekend recovery. Participants were 12 healthy secondary school students (six male) aged 15-17 years [mean = 16.1 years, standard deviation (SD) = 0.9]. After 2 nights with 10 h (21:30-07:30 hours), time in bed was restricted to 5 h for 5 nights (02:30-07:30 hours), then returned to 10 h time in bed for 2 nights (21:30-07:30 hours)...
November 21, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27868206/impact-of-short-sleep-on-metabolic-variables-in-obese-children-with-obstructive-sleep-apnea
#15
Bharat Bhushan, Bushra Ayub, Dana M Thompson, Fizan Abdullah, Kathleen R Billings
OBJECTIVES/HYPOTHESIS: To analyze the association between sleep duration, metabolic variables, and insulin resistance in obese children with and without obstructive sleep apnea. The decline in sleep duration has paralleled a dramatic increase in the prevalence of obesity and diabetes, suggesting a mechanistic relationship. STUDY DESIGN: Retrospective, case series. METHODS: Consecutive obese patients 3 to 12 years of age who underwent polysomnography (PSG) and a metabolic panel and who completed a 14-item sleep questionnaire were analyzed...
November 21, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27864041/apnea-hypopnea-index-prediction-through-an-assessment-of-autonomic-influence-on-heart-rate-in-wakefulness
#16
Da Woon Jung, Yu Jin Lee, Do-Un Jeong, Kwang Suk Park
With the high prevalence of obstructive sleep apnea, the issue of developing a practical tool for obstructive sleep apnea screening has been raised. Conventional obstructive sleep apnea screening tools are limited in their ability to help clinicians make rational decisions due to their inability to predict the apnea-hypopnea index. Our study aimed to develop a new prediction model that can provide a reliable apnea-hypopnea index value during wakefulness. We hypothesized that patients with more severe obstructive sleep apnea would exhibit more attenuated waking vagal tone, which may result in lower effectiveness in decreasing heart rate as a response to deep inspiration breath-holding...
November 15, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27863318/characteristics-of-objective-daytime-sleep-among-individuals-with-earthquake-related-posttraumatic-stress-disorder-a-pilot-community-based-polysomnographic-and-multiple-sleep-latency-test-study
#17
Yan Zhang, Yun Li, Hongru Zhu, Haofei Cui, Changjian Qiu, Xiangdong Tang, Wei Zhang
Little is known about the objective sleep characteristics of patients with posttraumatic stress disorder (PTSD). The present study examines the association between PTSD symptom severity and objective daytime sleep characteristics measured using the Multiple Sleep Latency Test (MSLT) in therapy-naïve patients with earthquake-related PTSD. A total of 23 PTSD patients and 13 trauma-exposed non-PTSD (TEN-PTSD) subjects completed one-night in-lab polysomnography (PSG) followed by a standard MSLT. 8 of the 23 PTSD patients received paroxetine treatment...
September 21, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27861249/the-antihypertensive-effects-of-aerobic-versus-isometric-handgrip-resistance-exercise
#18
Garrett I Ash, Beth A Taylor, Paul D Thompson, Hayley V MacDonald, Lauren Lamberti, Ming-Hui Chen, Paulo Farinatti, William J Kraemer, Gregory A Panza, Amanda L Zaleski, Ved Deshpande, Kevin D Ballard, Mohammadtokir Mujtaba, C Michael White, Linda S Pescatello
BACKGROUND: Aerobic exercise reduces blood pressure (BP) on average 5-7 mmHg among those with hypertension; limited evidence suggests similar or even greater BP benefits may result from isometric handgrip (IHG) resistance exercise. METHOD: We conducted a randomized controlled trial investigating the antihypertensive effects of an acute bout of aerobic compared with IHG exercise in the same individuals. Middle-aged adults (n = 27) with prehypertension and obesity randomly completed three experiments: aerobic (60% peak oxygen uptake, 30 min); IHG (30% maximum voluntary contraction, 4 × 2 min bilateral); and nonexercise control...
November 16, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27860160/effect-of-one-week-of-cpap-treatment-of-obstructive-sleep-apnoea-on-24-h-profiles-of-glucose-insulin-and-counter-regulatory-hormones-in-type-2-diabetes
#19
Babak Mokhlesi, Daniela Grimaldi, Guglielmo Beccuti, Eve Van Cauter
Studies examining the impact of CPAP treatment on glycaemic control have yielded conflicting results. We examined the 24-h profiles of glucose, insulin and counter-regulatory hormones in twelve subjects with type 2 diabetes and OSA before and after one week of effective in-laboratory CPAP therapy over an entire 8-h night. Blood samples were collected every 15-30 minutes for 24 hours under controlled conditions. The 24-h mean glucose decreased from 153.2 ± 33.0 to 139.7 ± 24.2 mg/dL with CPAP (-13...
November 17, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27852169/fatigue-in-a-population-based-cohort-of-patients-with-inflammatory-bowel-disease-20-years-after-diagnosis-the-ibsen-study
#20
Gert Huppertz-Hauss, Marte Lie Høivik, Lars-Petter Jelsness-Jørgensen, Randi Opheim, Magne Henriksen, Ole Høie, Øistein Hovde, Iril Kempski-Monstad, Inger Camilla Solberg, Jørgen Jahnsen, Geir Hoff, Bjørn Moum, Tomm Bernklev
OBJECTIVE: Fatigue is a major concern for patients with ulcerative colitis (UC) and Crohn's disease (CD), but evidence from population-based studies regarding fatigue in long-standing inflammatory bowel disease (IBD) patients is scarce. Our aims were to assess fatigue scores and the prevalence of chronic fatigue in IBD patients 20 years after diagnosis and to identify variables associated with fatigue in this cohort. METHODS: Twenty years after diagnosis, patients from a cohort with incident IBD were invited to a follow-up visit that included a structured interview, a clinical examination, laboratory tests and the Fatigue Questionnaire (FQ)...
November 17, 2016: Scandinavian Journal of Gastroenterology
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