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https://www.readbyqxmd.com/read/28412911/pharmacological-therapy-of-abdominal-aortic-aneurysm-an-update
#1
Yi-Dong Wang, Zhen-Jie Liu, Jun Ren, Mei-Xiang Xiang
Abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic dilation, is associated with high mortality. AAA is characterized by inflammation, smooth muscle cell (SMC) depletion and extracellular matrix (ECM) degradation. Surgical intervention and endovascular therapy are recommended to prevent rupture of large AAAs. Unfortunately, there is no reliable pharmacological agent available to limit AAA expansion. In the past decades, extensive investigations and a body of ongoing clinical trials aimed at defining potent treatments to inhibit and even regress AAA growth...
April 13, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28409388/diethylcarbamazine-attenuates-the-expression-of-pro-fibrogenic-markers-and-hepatic-stellate-cells-activation-in-carbon-tetrachloride-induced-liver-fibrosis
#2
Maria Eduarda Rocha de França, Sura Wanessa Santos Rocha, Wilma Helena Oliveira, Laise Aline Santos, Anne Gabrielle Vasconcelos de Oliveira, Karla Patrícia Sousa Barbosa, Ana Karolina Santana Nunes, Gabriel Barros Rodrigues, Deniele Bezerra Lós, Christina Alves Peixoto
BACKGROUND AND AIM: While diethylcarbamazine citrate (DEC) displays important anti-inflammatory effects in experimental models of liver injury, the mechanisms of its action remain poorly understood. The aim of the present study was to investigate the fibrolytic potential of DEC. METHODS: Mice receive two injections of carbon tetrachloride (CCl4) per week for 8 weeks. DEC 50 mg/kg body weight was administered through drinking water during the last 12 days of liver injury...
April 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28323397/in-vivo-response-to-decellularized-mesothelium-scaffolds
#3
Michael J Cronce, Renea A Faulknor, Irina Pomerantseva, Xiang-Hong Liu, Scott M Goldman, Emmanuel C Ekwueme, Olive Mwizerwa, Craig M Neville, Cathryn A Sundback
Biological surgical scaffolds are used in plastic and reconstructive surgery to support structural reinforcement and regeneration of soft tissue defects. Macrophage and fibroblast cell populations heavily regulate scaffold integration into host tissue following implantation. In the present study, the biological host response to a commercially available surgical scaffold (Meso BioMatrix Surgical Mesh (MBM)) was investigated for up to 9 weeks after subcutaneous implantation; this scaffold promoted superior cell migration and infiltration previously in in vitro studies relative to other commercially available scaffolds...
March 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28176948/theophylline-action-on-primary-human-bronchial-epithelial-cells-under-proinflammatory-stimuli-and-steroidal-drugs-a-therapeutic-rationale-approach
#4
Luca Gallelli, Daniela Falcone, Roberto Cannataro, Mariarita Perri, Raffaele Serra, Girolamo Pelaia, Rosario Maselli, Rocco Savino, Giuseppe Spaziano, Bruno D'Agostino
Theophylline is a natural compound present in tea. Because of its property to relax smooth muscle it is used in pharmacology for the treatment of airway diseases (ie, chronic obstructive pulmonary disease, asthma). However, this effect on smooth muscle is dose dependent and it is related to the development of side effects. Recently, an increasing body of evidence suggests that theophylline, at low concentrations, also has anti-inflammatory effects related to the activation of histone deacetylases. In this study, we evaluated the effects of theophylline alone and in combination with corticosteroids on human bronchial epithelial cells under inflammatory stimuli...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27815257/sirt3-blocks-myofibroblast-differentiation-and-pulmonary-fibrosis-by-preventing-mitochondrial-dna-damage
#5
Samik Bindu, Vinodkumar B Pillai, Abhinav Kanwal, Sadhana Samant, Gökhan M Mutlu, Eric Verdin, Nickolai Dulin, Mahesh P Gupta
Myofibroblast differentiation is a key process in the pathogenesis of fibrotic diseases. Transforming growth factor-β1 (TGF-β1) is a powerful inducer of myofibroblast differentiation and is implicated in pathogenesis of tissue fibrosis. This study was undertaken to determine the role of mitochondrial deacetylase SIRT3 in TGF-β1-induced myofibroblast differentiation in vitro and lung fibrosis in vivo. Treatment of human lung fibroblasts with TGF-β1 resulted in increased expression of fibrosis markers, smooth muscle α-actin (α-SMA), collagen-1, and fibronectin...
January 1, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27766053/new-horizon-in-platelet-function-with-special-reference-to-a-recently-found-molecule-clec-2
#6
REVIEW
Yukio Ozaki, Shogo Tamura, Katsue Suzuki-Inoue
Platelets play a key role in the pathophysiological processes of hemostasis and thrombus formation. However, platelet functions beyond thrombosis and hemostasis have been increasingly identified in recent years. A large body of evidence now exists which suggests that platelets also play a key role in inflammation, immunity, malignancy, and furthermore in organ development and regeneration, such as the liver. We have recently identified CLEC-2 on the platelet membrane, which induces intracellular activation signals upon interaction of a snake venom, rhodocytin...
2016: Thrombosis Journal
https://www.readbyqxmd.com/read/27699693/elemental-and-immunohistochemical-analysis-of-the-lungs-and-hilar-lymph-node-in-a-patient-with-asbestos-exposure-a-pilot-study
#7
Yasuhiko Koga, Takahiro Satoh, Kyoichi Kaira, Masashi Koka, Takeshi Hisada, Junko Hirato, Bolag Altan, Masakiyo Yatomi, Akihiro Ono, Yosuke Kamide, Yasuo Shimizu, Haruka Aoki-Saito, Hiroaki Tsurumaki, Kimihiro Shimizu, Akira Mogi, Tamotsu Ishizuka, Masanobu Yamada, Kunio Dobashi
OBJECTIVES: Studies have shown that inhaled mine dust, such as asbestos, can be translocated to various organs including the lymph nodes. Recently, we have established a protocol that enables us to identify inhaled elements using paraffin embedded lung specimens by in-air microparticle-induced X-ray emission (micro-PIXE). However, little research has examined the concentration of these inhaled fibers in various organs or the mechanisms of their translocation. In this study, we compared the concentration of inhaled fibers in the lung parenchyma to the concentration in the hilar lymph node as well as to determine the elemental spatial distribution of the inhaled fibers in a patient with occupational asbestos exposure...
November 2016: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/27698175/canine-mammary-minute-oncocytomas-with-neuroendocrine-differentiation-associated-with-multifocal-acinar-cell-oncocytic-metaplasia
#8
Rei Nagahara, Masayuki Kimura, Megu Itahashi, Go Sugahara, Masashi Kawashima, Hirotada Murayama, Toshinori Yoshida, Makoto Shibutani
Two solitary and minute tumors of 1 and 1.5 mm diameter were identified by microscopy in the left fourth mammary gland of a 13-year-old female Labrador Retriever dog, in addition to multiple mammary gland tumors. The former tumors were well circumscribed and were composed of small-to-large polyhedral neoplastic oncocytes with finely granular eosinophilic cytoplasm, and were arranged in solid nests separated by fine fibrovascular septa. Scattered lumina of variable sizes containing eosinophilic secretory material were evident...
November 2016: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/27476938/protective-effect-of-ginsenoside-rg1-on-bleomycin-induced-pulmonary-fibrosis-in-rats-involvement-of-caveolin-1-and-tgf-%C3%AE-1-signal-pathway
#9
Heqin Zhan, Feng Huang, Wenzhuo Ma, Zhenghang Zhao, Haifang Zhang, Chong Zhang
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis and high mortality rate. Panax Notoginseng Saponins (PNS), extracted from Panax Notoginseng as a traditional Asian medicine, displayed a significant anti-fibrosis effect in liver and lung. However, whether Ginsenoside Rg1 (Rg1), an important and active ingredient of PNS, exerts anti-fibrotic activity on IPF still remain unclear. In this study, we investigated the effect of Rg1 on bleomycin-induced pulmonary fibrosis in rats. Bleomycin (5 mg/kg body weight) was intratracheally administrated to male rats...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27465365/herbal-composition-of-cinnamomum-cassia-pinus-densiflora-curcuma-longa-and-glycyrrhiza-glabra-prevents-atherosclerosis-by-upregulating-p27-kip1-expression
#10
Jung-Jin Lee, Ji-Hye Lee, Won-Kyung Cho, Joo-Hui Han, Jin Yeul Ma
BACKGROUND: Kiom-18 is a novel composition of Cinnamomum cassia, Pinus densiflora, Curcuma longa and Glycyrrhiza glabra. Curcuma longa and Glycyrrhiza glabra, which are traditional medicines in Asia, have been reported to demonstrate preventive effects against atherosclerosis; however, they have not yet been developed into functional atherosclerosis treatments. We therefore studied the anti-atherosclerotic effects and possible molecular mechanisms of Kiom-18 using vascular smooth muscle cells (VSMCs)...
July 28, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27455221/qingxuan-jiangya-decoction-reverses-vascular-remodeling-by-inducing-vascular-smooth-muscle-cell-apoptosis-in-spontaneously-hypertensive-rats
#11
Fei Xiao, Fei He, Hongwei Chen, Shan Lin, Aling Shen, Youqin Chen, Jianfeng Chu, Jun Peng
Qingxuan Jiangya Decoction (QXJYD), a traditional Chinese medicine formula prescribed by academician Ke-ji Chen, has been used in China to clinically treat hypertension for decades of years. However, the molecular mechanisms of its action remain largely unknown. In this study, we examined the therapeutic efficacy of QXJYD against elevated systolic blood pressure in the spontaneously hypertensive rat (SHR) model, and investigated the underlying molecular mechanisms. We found that oral administration of QXJYD significantly reduced the elevation of systolic blood pressure in SHR but had no effect on body weight change...
July 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27334733/bronchodilator-and-anti-inflammatory-action-of-theophylline-in-a-model-of-ovalbumin-induced-allergic-inflammation
#12
A Urbanova, M Kertys, M Simekova, P Mikolka, P Kosutova, D Mokra, J Mokry
Phosphodiesterases (PDEs) represent a super-family of 11 enzymes hydrolyzing cyclic nucleotides into inactive 5' monophosphates. Inhibition of PDEs leads to a variety of cellular effects, including airway smooth muscle relaxation, inhibition of cellular inflammation, and immune responses. In this study we focused on theophylline, a known non-selective inhibitor of PDEs. Theophylline has been used for decades in the treatment of chronic inflammatory airway diseases. It has a narrow therapeutic window and belongs to the drugs whose plasma concentration should be monitored...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27275589/the-influence-of-nicotine-in-healing-of-small-bowel-anastomoses-in-rats-angiogenesis-and-miofibroblasts
#13
James Skinovsky, Osvaldo Malafaia, Mauricio Chibata, Fernanda Tsumanuma, Flávio Panegalli, Marcus Vinícius Dantas de Campos Martins
OBJECTIVE: to know the effect of nicotine on angiogenesis and myofibroblast formation in anastomoses of the small bowel of rats. METHODS: we randomly divided 60 Wistar rats into the groups Nicotine (N) and control (C), according to the proposed treatment. Each group was subdivided into three subgroups according to the time interval used for the evaluation (7, 14 or 28 days). The N group with 30 animals received nicotine subcutaneously at a dose of 2mg/kg body weight, diluted in 0...
March 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27271612/preventive-effects-of-rhodiola-rosea-l-on-bleomycin-induced-pulmonary-fibrosis-in-rats
#14
Ke Zhang, Xiao-Ping Si, Jian Huang, Jian Han, Xu Liang, Xiao-Bo Xu, Yi-Ting Wang, Guo-Yu Li, Hang-Yu Wang, Jin-Hui Wang
Rhodiola rosea L. (RRL) possesses a wide range of pharmacological properties, including lung-protective activity, and has been utilized in folk medicine for several 100 years. However, the lung-protective mechanism remains unclear. This study investigated the possible lung-protective activity mechanism of RRL in a pulmonary fibrosis (PF) rat model. Lung fibrotic injury was induced in Sprague-Dawley rats by single intratracheal instillation of saline containing bleomycin (BLM; 5 mg/kg). The rats were administered 125, 250, or 500 mg/kg of a 95% ethanol extract of RRL for 28 days...
June 3, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27216772/chronic-intermittent-hypobaric-hypoxia-antagonizes-renal-vascular-hypertension-by-enhancement-of-vasorelaxation-via-activating-bkca
#15
REVIEW
Yue Guan, Na Li, Yan-Ming Tian, Li Zhang, Hui-Jie Ma, Leonid N Maslov, Sheng Wang, Yi Zhang
AIM: The purpose of the present study was to explore anti-hypertensive effect of chronic intermittent hypobaric hypoxia (CIHH) in renovascular hypertension (RVH) rats, as well as the role of large-conductance calcium-activated potassium channel (BKCa) in anti-hypertensive effect of CIHH. MAIN METHODS: Male adult age- and body weight-matched Sprague-Dawley rats were divided into SHAM, CIHH, RVH and RVH+CIHH groups. Hypertension was induced by two-kidney-1-clip method (2K1C) in RVH rats...
July 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27173468/anagliptin-a-dipeptidyl-peptidase-4-inhibitor-decreases-macrophage-infiltration-and-suppresses-atherosclerosis-in-aortic-and-coronary-arteries-in-cholesterol-fed-rabbits
#16
Tsutomu Hirano, Satoko Yamashita, Masaki Takahashi, Hiroyuki Hashimoto, Yusaku Mori, Moritaka Goto
INTRODUCTION: Several studies have demonstrated suppression of aortic atherosclerosis by dipeptidyl peptidase-4 (DPP-4) inhibitors in hypercholesterolemic mice. However, it remains unknown whether DPP-4 inhibitors also exert anti-atherogenic effects in coronary arteries. We examined the effect of anagliptin, a DPP-4 inhibitor, on atherosclerosis development in the aorta and coronary arteries in a high-cholesterol diet-fed rabbits. METHODS: Japanese white rabbits were fed either normal chow (n=8) or a diet containing 0...
June 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27019387/florid-intussusceptive-like-microvascular-dysangiogenesis-in-a-preterm-lung
#17
Monique E De Paepe, Merline Kocheekkaran V Benny, Lauren Priolo, Francois I Luks, Svetlana Shapiro
The cellular mechanisms underlying the microvascular dysangiogenesis of bronchopulmonary dysplasia (BPD, chronic lung disease of the newborn) remain largely undetermined. We report unusual pulmonary vascular findings in a 27-week-gestation male newborn who died on the second day of life from intractable respiratory failure, following a pregnancy complicated by prolonged membrane rupture and persistent severe oligohydramnios. As expected, postmortem examination revealed pulmonary hypoplasia (lung/body weight ratio: 2...
March 28, 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/26905192/the-role-of-curcumin-in-streptozotocin-induced-hepatic-damage-and-the-trans-differentiation-of-hepatic-stellate-cells
#18
Hesham N Mustafa
Diabetic patients frequently suffer from non-alcoholic steatohepatitis. The current study aimed to investigate the role of curcumin and the response of hepatic stellate cells in streptozotocin (STZ)-induced hepatic damage. Sixty male rats were divided into three groups. The normal control injected with a citrate buffer vehicle and the diabetic control group which was injected intraperitoneally (IP) with a single-dose of streptozotocin (50mg/kg body weight) and a diabetic group was treated with an oral dose of curcumin at 80 mg/kg body weight daily for 60 days...
April 2016: Tissue & Cell
https://www.readbyqxmd.com/read/26746846/immunohistochemical-localization-of-renin-containing-cells-in-two-elasmobranch-species
#19
E R Lacy, E Reale, L Luciano
Renin immunoreactivity was localized at the light and electron microscopic level in two elasmobranch fish species, the Atlantic stingray, Dasyatis sabina, and river ray, Potamotrygon humerosa. At the light microscopic level, the peroxidase-anti-peroxidase method showed a positive immunoreactivity in modified smooth muscle cells in kidney afferent arterioles as well as in arterioles of several organs: rectal gland, inter-renal gland, conus arteriosus, and gill. Electron microscopic renin-positive immunogold localization was confined to the contents of membrane bound granules in the modified smooth muscle cells of these arterioles...
June 2016: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/26739410/administration-of-pigment-epithelium-derived-factor-inhibits-airway-inflammation-and-remodeling-in-chronic-ova-induced-mice-via-vegf-suppression
#20
Wangjian Zha, Mei Su, Mao Huang, Jiankang Cai, Qiang Du
PURPOSE: Pigment epithelium-derived factor (PEDF) is a recently discovered antiangiogenesis protein. PEDF possesses powerful anti-inflammatory, antioxidative, antiangiogenic, and antifibrosis properties. It has been reported that PEDF can regulate vascular endothelial growth factor (VEGF) expression. This study aimed to evaluate whether recombinant PEDF protein could attenuate allergic airway inflammation and airway remodeling via the negative regulation of VEGF using a murine model of chronic ovalbumin (OVA)-induced asthma and BEAS-2B human bronchial epithelial cells...
March 2016: Allergy, Asthma & Immunology Research
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