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https://www.readbyqxmd.com/read/29775572/gene-therapy-with-antisense-oligonucleotides-silencing-c-myc-reduces-neointima-formation-and-vessel-wall-thickness-in-a-mouse-model-of-vein-graft-disease
#1
Christina Maria Steger, Nikolaos Bonaros, Ralf Joachim Rieker, Johannes Bonatti, Thomas Schachner
Gene therapy for avoiding intimal hyperplasia of vein grafts after coronary artery bypass grafting is still discussed controversially. A promising application of gene therapy in vein grafts is the use of antisense oligonucleotides to block the expression of genes encoding cell cycle regulatory proteins in vascular smooth muscle cells. C-myc, either directly or by regulating the expression of other proteins, controls cell proliferation, apoptosis and cell survival, tissue remodeling, angiogenesis, cell metabolism, production of inflammatory and anti-inflammatory cytokines, and also participates in cell transformation...
May 15, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29772297/pharmacokinetic-profile-and-oral-bioavailability-of-kaurenoic-acid-from-copaifera-spp-in-rats
#2
Dalyara Mendonça de Matos, Milainy Rocha Viana, Marcela Cristina de Oliveira Alvim, Lara Soares Aleixo de Carvalho, Laura Hora Rios Leite, Ademar Alves da Silva Filho, Jorge Willian Leandro Nascimento
Kaurenoic acid (KA) is a kaurane diterpene found in several medicinal plants that displays biological activities, such as anti-inflammatory, smooth muscle relaxant and hypotensive response. However, there are no pharmacokinetic data available about this molecule. The purpose of the study was to determine the pharmacokinetics profile and the oral bioavailability of KA in rats. Wistar rats submitted to jugular vein cannulation received 50 mg/kg of KA by intravenous or oral route. The implanted cannula allowed intravenous administration and serial blood collection along 10 h...
May 14, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29768263/fibrinopeptide-a-induces-expression-of-c-reactive-protein-via-the-ros-erk1-2-p38-nf-%C3%AE%C2%BAb-signal-pathway-in-vascular-smooth-muscle-cells
#3
Shouzhu Xu, Jing Zhao, Juntian Liu, Wei Gou
BACKGROUND/AIMS: Atherosclerosis is a chronic inflammatory disease in the artery walls. Fibrinopeptide A (FPA) is a biomarker of the activation of coagulation system, and a high concentration of FPA in blood occurs in patients with ischemic heart disease etc. However, there exist few studies on the pathological effects of FPA in cardiovascular system. Therefore, the present study examined the effect of FPA on CRP expression in VSMCs and the molecular mechanisms. METHODS: mRNA and protein expression was identified by quantitative real-time PCR and Western blot, respectively...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29765446/inhibitory-effect-of-pdgf-bb-and-serum-stimulated-responses-in-vascular-smooth-muscle-cell-proliferation-by-hinokitiol-via-up-regulation-of-p21-and-p53
#4
Jiun-Yi Li, Chun-Ping Liu, Wei-Cheng Shiao, Thanasekaran Jayakumar, Yi-Shin Li, Nen-Chung Chang, Shih-Yi Huang, Cheng-Ying Hsieh
Introduction: Vascular smooth muscle cell (VSMC) proliferation plays a major role in the progression of vascular diseases. In the present study, we established the efficacy and the mechanisms of action of hinokitiol, a tropolone derivative found in Chamaecyparis taiwanensis , Cupressaceae, in relation to platelet-derived growth factor-BB (PDGF-BB) and serum-dependent VSMC proliferation. Material and methods: Primary cultured rat VSMCs were pre-treated with hinokitiol and then stimulated by PDGF-BB (10 ng/ml) or serum (10% fetal bovine serum)...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29765072/notoginsenoside-r1-inhibits-vascular-smooth-muscle-cell-proliferation-migration-and-neointimal-hyperplasia-through-pi3k-akt-signaling
#5
Haihong Fang, Shilin Yang, Yingying Luo, Cheng Zhang, Yi Rao, Renjing Liu, Yulin Feng, Jun Yu
Restenosis caused by neointimal hyperplasia significantly decreases long-term efficacy of percutaneous transluminal angioplasty (PTA), stenting, and by-pass surgery for managing coronary and peripheral arterial diseases. A major cause of pathological neointima formation is abnormal vascular smooth muscle cell (VSMC) proliferation and migration. Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng and has reported cardioprotective, neuroprotective and anti-inflammatory effects...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764457/video-mediastinoscopy-assisted-fish-bone-extraction-and-superior-medistinal-abscess-debridement
#6
Jun Wang, Wei Bing Wu, Liang Chen, Quan Zhu
BACKGROUND: Mediastinum abscess caused by sharp esophageal foreign body perforation usually needs surgical treatment, and the surgical procedures vary according to size of perforation and scope of abscess, etc. For special case with small esophageal mucosal crevasse and focal abscess confined to mediastinum, minimally invasive surgery with guidance of video-mediastinoscopy would be an alternative method, however, application of video-mediastinoscopy in this life-threatening situation was rarely reported...
May 15, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29762881/colchicine-a-microtubule-disassembling-drug-in-the-therapy-of-cardiovascular-diseases
#7
George N Chaldakov
Colchicum autumnale, from which colchicine has been isolated more than 100 years ago, has been used as a treatment for pain and swelling for thousands of years. It is one of the few drugs known from that time period whose use has survived to modernity. Over the past decades, advances in the knowledge of (i) cytoskeletal microtubules (МТ), and (ii) anti-inflammatory and anti-fibrotic effects of colchicine, a classical MT-disassembling (tubulin-targeting) agent, have led to potential new uses for this very old drug extended beyond acute gouty arthritis and familial Mediterranean fever...
May 15, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29753567/junctional-adhesion-molecules-jam-b-and-jam-c-promote-autoimmune-mediated-liver-fibrosis-in-mice
#8
Edith Hintermann, Monika Bayer, Clara Benedetta Conti, Sina Fuchs, Michel Fausther, Patrick S Leung, Michel Aurrand-Lions, Richard Taubert, Josef M Pfeilschifter, Mireen Friedrich-Rust, Detlef Schuppan, Jonathan A Dranoff, M Eric Gershwin, Michael P Manns, Beat A Imhof, Urs Christen
Fibrosis remains a serious health concern in patients with chronic liver disease. We recently reported that chemically induced chronic murine liver injury triggers increased expression of junctional adhesion molecules (JAMs) JAM-B and JAM-C by endothelial cells and de novo synthesis of JAM-C by hepatic stellate cells (HSCs). Here, we demonstrate that biopsies of patients suffering from primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) or autoimmune hepatitis (AIH) display elevated levels of JAM-C on portal fibroblasts (PFs), HSCs, endothelial cells and cholangiocytes, whereas smooth muscle cells expressed JAM-C constitutively...
May 9, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29751345/facile-fabrication-of-bowl-shaped-microparticles-for-oral-curcumin-delivery-to-ulcerative-colitis-tissue
#9
Qiubing Chen, Shuangquan Gou, Yamei Huang, Xin Zhou, Qian Li, Moon Kwon Han, Yuejun Kang, Bo Xiao
Oral microparticles (MPs) have been considered as promising drug carriers in the treatment of ulcerative colitis (UC). Here, a facile strategy based on a conventional emulsion-solvent evaporation technique was used to fabricate bowl-shaped MPs (BMPs), and these MPs loaded with anti-inflammatory drug (curcumin, CUR) during the fabrication process. The physicochemical properties of the resultant BMPs were characterized by dynamic light scattering, scanning electron microscope, confocal laser scanning microscope and X-ray diffraction as well as contact angle goniometer...
May 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29746862/induction-of-inactive-tgf-%C3%AE-1-monomer-formation-by-hydrogen-sulfide-contributes-to-its-suppressive-effects-on-ang-ii-and-tgf-%C3%AE-1-induced-emt-in-renal-tubular-epithelial-cells
#10
Yong Huang, Zhen Zhang, Yanru Huang, Zhimin Mao, Xiawen Yang, Yuki Nakamura, Norifumi Sawada, Takahiko Mitsui, Masayuki Takeda, Jian Yao
Hydrogen sulfide (H2 S), an endogenous gas mediator with multifaced biological functions, has been shown to be effective in the prevention and treatment of renal sclerosis in several models of chronic renal diseases. The mechanisms involved are still unclear. Given that Ang II- and TGF-β-induced renal tubular epithelial-mesenchymal transition (EMT) is a pivotal cellular event leading to renal sclerosis, we examined whether and how H2 S intervened the processes of EMT. Ang II stimulated EMT in renal tubular epithelial cells, as indicated by the increased level of α-smooth muscle actin and a decreased level of E-cadherin...
May 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29743728/spatially-correlated-phenotyping-reveals-k5-positive-luminal-progenitor-cells-and-p63-k5-14-positive-stem-cell-like-cells-in-human-breast-epithelium
#11
Werner Boecker, Laura van Horn, Göran Stenman, Christine Stürken, Udo Schumacher, Thomas Loening, Lukas Liesenfeld, Eberhard Korsching, Doreen Gläser, Katharina Tiemann, Igor Buchwalow
Understanding the mechanisms regulating human mammary epithelium requires knowledge of the cellular constituents of this tissue. Different and partially contradictory definitions and concepts describing the cellular hierarchy of mammary epithelium have been proposed, including our studies of keratins K5 and/or K14 as markers of progenitor cells. Furthermore, we and others have suggested that the p53 homolog p63 is a marker of human breast epithelial stem cells. In this investigation, we expand our previous studies by testing whether immunohistochemical staining with monospecific anti-keratin antibodies in combination with an antibody against the stem cell marker p63 might help refine the different morphologic phenotypes in normal breast epithelium...
May 9, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29743620/novel-polymer-free-everolimus-eluting-stent-fabricated-using-femtosecond-laser-improves-re-endothelialization-and-anti-inflammation
#12
In-Ho Bae, Myung Ho Jeong, Kyung Seob Lim, Dae Sung Park, Jae Won Shim, Jun-Kyu Park, Kwang Hwan Oh, Mi Rim Jin, Doo Sun Sim
The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both platelet adhesion (82.1%) and smooth muscle cell response. Animal study was performed using a porcine coronary restenosis model. The study groups were divided into 1) bare metal stent (BMS), 2) poly(L-lactide) (PLA)-based EVL drug eluting stent (DES), 3) commercial EVL-eluting DES, and 4) FSL-EVL-DES...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743070/the-anti-proliferative-and-anti-inflammatory-response-of-copd-airway-smooth-muscle-cells-to-hydrogen-sulfide
#13
Mark M Perry, Bernadett Tildy, Alberto Papi, Paolo Casolari, Gaetano Caramori, Karen Limbert Rempel, Andrew J Halayko, Ian Adcock, Kian Fan Chung
BACKBROUND: COPD is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease caused, in part, by the aberrant function of airway smooth muscle (ASM). We have previously demonstrated that hydrogen sulfide (H2 S) can inhibit ASM cell proliferation and CXCL8 release, from cells isolated from non-smokers. METHODS: We examined the effect of H2 S upon ASM cells from COPD patients...
May 9, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29740320/amifostine-analog-drde-30-attenuates-bleomycin-induced-pulmonary-fibrosis-in-mice
#14
Aastha Arora, Vikas Bhuria, Puja P Hazari, Uma Pathak, Sweta Mathur, Bal G Roy, Rajat Sandhir, Ravi Soni, Bilikere S Dwarakanath, Anant N Bhatt
Bleomycin (BLM) is an effective curative option in the management of several malignancies including pleural effusions; but pulmonary toxicity, comprising of pneumonitis and fibrosis, poses challenge in its use as a front-line chemotherapeutic. Although Amifostine has been found to protect lungs from the toxic effects of radiation and BLM, its application is limited due to associated toxicity and unfavorable route of administration. Therefore, there is a need for selective, potent, and safe anti-fibrotic drugs...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29740240/antifibrotic-effects-of-crocin-on-thioacetamide-induced-liver-fibrosis-in-mice
#15
Mardi M Algandaby
Liver fibrosis is a major health concern that results in significant morbidity and mortality. Up-to-date, there is no standard treatment for fibrosis because of its complex pathogenesis. Crocin is one of the main nutraceuticals isolated from the stigma of Crocus sativus with antioxidant and anti-inflammatory activities. The current study aimed at evaluating the potential antifibrotic activity of crocin against thioacetamide (TAA)-induced liver fibrosis in mice as well as the underlying mechanism using silymarin as a reference antifibrotic product...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29738368/anti-apoptotic-effect-of-%C3%AE-1-blockers-in-ascending-thoracic-aortic-smooth-muscle-cells-the-role-of-hsp70-expression
#16
Ioannis K Rizos, James N Tsoporis, Ioannis K Toumpoulis, Vasileios Salpeas, Shehla Izhar, Angelos G Rigopoulos, Eleftherios A Sakadakis, Thomas G Parker
Heat shock proteins (HSP) play an important role in the cellular adaptation to stress, a requisite for cell survival. The aortic wall appears to be a target for increased expression of HSP during surgical stress. We aimed to define the expression and function of aortic HSP70 in 31 patients with normal ascending thoracic aortic diameter who underwent aortic valve replacement due to aortic valve stenosis (AVS) and in 35 patients with dilated ascending thoracic aorta who underwent replacement of an ascending thoracic aortic aneurysm (ATAA)...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29737163/rhodium-catalyzed-highly-regio-and-stereoselective-intermolecular-hydrosilylation-of-internal-ynamides-under-mild-conditions
#17
Nan Zheng, Wangze Song, Tiexin Zhang, Ming Li, Yubin Zheng, Lingyue Chen
A rhodium-catalyzed highly regio- and stereoselective intermolecular hydrosilylation of internal ynamides has been developed. With the neutral rhodium complex [Rh(CO)2Cl]2 as catalyst and the bulky silanes as reactants, various ynamides underwent hydrosilylation smoothly at room temperature with excellent β regioselectivity and anti stereoselectivity. The synthetically versatile β-silyl (Z)-enamide products could be further transformed to diverse useful building blocks. Several possible mechanisms are proposed to rationalize this unique formal trans-addition-type selectivity...
May 8, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29729548/pepducins-as-a-potential-treatment-strategy-for-asthma-and-copd
#18
REVIEW
Reynold A Panettieri, Tonio Pera, Stephen B Liggett, Jeffrey L Benovic, Raymond B Penn
Current therapies to treat asthma and other airway diseases primarily include anti-inflammatory agents and bronchodilators. Anti-inflammatory agents target trafficking and resident immunocytes and structural cells, while bronchodilators act to prevent or reverse shortening of airway smooth muscle (ASM), the pivotal tissue regulating bronchomotor tone. Advances in our understanding of the biology of G protein-coupled receptors (GPCRs) and biased agonism offers unique opportunities to modulate GPCR function that include the use of pepducins and allosteric modulators...
May 2, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29728095/puerarin-inhibits-vascular-smooth-muscle-cells-proliferation-induced-by-fine-particulate-matter-via-suppressing-of-the-p38-mapk-signaling-pathway
#19
Qiang Wan, Zhongyong Liu, Yuping Yang
BACKGROUND: Fine particulate matter (PM2.5) is a major risk factor for the development and progression of atherosclerosis. Proliferation and infiltration of vascular smooth muscle cells (VSMCs) from the blood vessel media into the intima is a crucial step in the pathophysiology of atherosclerosis. Puerarin, a natural extract from Radix Puerariae, possesses significant anti-atherosclerosis properties. However, the underlying molecular mechanisms responsible for the effect of puerarin on the VSMCs proliferation induced by PM2...
May 4, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29724149/mesenchymal-stem-cell-sheets-exert-anti-stenotic-effects-in-a-rat-arterial-injury-model
#20
Jun Homma, Hidekazu Sekine, Katsuhisa Matsuura, Eiji Kobayashi, Tatsuya Shimizu
Restenosis after catheter or surgical intervention substantially affects the prognosis of arterial occlusive disease. Mesenchymal stem cells (MSCs) may have anti-stenotic effects on injured arteries. MSC transplantation from the adventitial side of an artery is safer than endovascular transplantation but has not been extensively examined. In this study, a rat model of femoral artery injury was used to compare the anti-stenotic effects of transplanted cell sheets and transplanted cell suspensions. Rat adipose-derived stem cells (ASCs) were used as the source of MSCs...
May 4, 2018: Tissue Engineering. Part A
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