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https://www.readbyqxmd.com/read/27916451/progressive-development-of-endometriosis-and-its-hindrance-by-anti-platelet-treatment-in-mice-with-induced-endometriosis
#1
Qi Zhang, Xishi Liu, Sun-Wei Guo
We have recently shown that platelets drive smooth muscle metaplasia (SMM) and fibrogenesis in endometriosis through epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transdifferentiation (FMT). To see whether this is true in vivo, this prospective, randomized, and serially evaluated mouse investigation was conducted. Endometriosis was induced in female Balb/C mice, which were then randomly divided into two groups: Tanshinone IIA (TAN) and control (CTL) groups. TAN mice were treated with TAN but CTL mice received none...
November 21, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27904495/higher-frequency-of-brain-abnormalities-in-neuromyelitis-optica-spectrum-disorder-patients-without-primary-sj%C3%A3-gren-s-syndrome
#2
Li-Na Gu, Min Zhang, Hui Zhu, Jing-Yao Liu
Neuromyelitis optica spectrum disorder often co-exists with primary Sjögren's syndrome. We compared the clinical features of 16 neuromyelitis optica spectrum disorder patients with (n = 6) or without primary Sjögren's syndrome (n = 10). All patients underwent extensive clinical, laboratory, and MRI evaluations. There were no statistical differences in demographics or first neurological involvement at onset between neuromyelitis optica spectrum disorder patients with and without primary Sjögren's syndrome...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27900999/evaluating-anti-smd1-amino-acid-83-119-peptide-reactivity-in-children-with-systemic-lupus-erythematosus-and-other-immunological-diseases
#3
Hai-Ou Yang, Xiao-Qing Zhang, Qi-Hua Fu
BACKGROUND: SmD1-amino-acid 83-119 peptide (SmD183-119) is the major epitope of Smith (Sm) antigen, which is specific for adult systemic lupus erythematosus (SLE). The anti-SmD183-119 antibody has exhibited higher sensitivity and specificity than anti-Sm antibody in diagnosing adult SLE. However, the utility of anti-SmD183-119antibodies remains unclear in children with SLE (cSLE). This study aimed to assess the characteristics of anti-SmD183-119antibody in the diagnosis of cSLE. METHODS: Samples from 242 children with different rheumatological and immunological disorders, including autoimmune diseases (SLE [n = 46] and ankylosing spondylitis [AS, n = 11]), nonautoimmune diseases (Henoch-Schonlein purpura [HSP, n = 60], idiopathic thrombocytopenia purpura [n = 27], hematuria [n = 59], and arthralgia [n = 39]) were collected from Shanghai Children's Medical Center from March 6, 2012 to February 27, 2014...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27892863/nutrigenomic-activity-of-plant-derived-compounds-in-health-and-disease-results-of-a-dietary-intervention-study-in-dog
#4
Sandy Sgorlon, Bruno Stefanon, Misa Sandri, Monica Colitti
The study was conducted to investigate the effects of dietary administrations of four nutraceuticals in dogs. Seventy four dogs were enrolled in the trials, 24 healthy dogs were fed with a control diet (CT) and the experimental groups received for 60days the same diet supplemented with nutraceuticals, namely Echinacea angustifolia (EA, 0.10mg/kg live weight as echinacoside; 14 dogs), Vaccinium myrtillus (VM, 0.20mg/kg live weight as anthocyanidin, 13 dogs), Curcuma longa (CL, 6.60mg/kg live weight as curcumin, 18 dogs with arthrosis), and Sylibum marianum (SM, 1...
October 13, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27891311/comparison-of-antibacterial-efficacy-of-coconut-oil-and-chlorhexidine-on-streptococcus-mutans-an-in-vivo-study
#5
Faizal C Peedikayil, Vimal Remy, Seena John, T P Chandru, Prathima Sreenivasan, Gufran Ahmed Bijapur
AIMS: Streptococcus mutans is the most common organism causing dental caries. Various chemotherapeutic agents are available that help in treating the bacteria, with each having their own merits and demerits. Recent research has shown that coconut oil has anti-inflammatory and antimicrobial action. Therefore, the present was conducted to determine the antibacterial efficacy of coconut oil and to compare it with chlorhexidine. MATERIALS AND METHODS: A total of fifty female children aged 8-12 years were included in the study...
September 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27879408/a-dual-label-time-resolved-fluorescence-immunoassay-for-the-simultaneous-determination-of-cardiac-troponin-t-and-myoglobin
#6
Ling Wang, Mujuan Xu, Ruolan Huang, Xiao Chang, Cuicui Chen, Laiqing Li, Zhong Zhang, Yue Han
The aim of this study was to establish a dual-label time-resolved fluorescence immunoassay (TRFIA) for the simultaneous determination of cardiac troponin T (cTnT) and myoglobin (MYO) for the early diagnosis of acute myocardial infarction. The sandwich immunoassay was used to detect the concentration of cTnT and MYO in serum. cTnT and MYO in serum were captured by anti-cTnT and anti-MYO antibodies immobilized on microtiter wells and then banded together with another anti-cTnT and anti-MYO labeled with europium(III) Sm(3+) and samarium(III) Eu(3+) chelates, followed by fluorescence measurement using time-resolved fluorometry...
November 22, 2016: Journal of Laboratory Automation
https://www.readbyqxmd.com/read/27864674/interactions-between-giardia-duodenalis-sm-proteins-and-their-association-with-spliceosomal-snrnas
#7
Vanessa Gómez, Moisés Wasserman
Giardia duodenalis is a parasite that colonises the intestines of humans and other vertebrates, causing diarrhoea and poor nutrient absorption. G. duodenalis is sometimes considered an early diverging eukaryote, and its genome exhibits simplified molecular machinery for many cellular processes, which makes it an interesting model to study. The spliceosome, one of the most complex molecular machines in the eukaryotic cell, is responsible for intron excision and exon splicing. Just over a decade ago, it was believed that the G...
November 18, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27837197/comparison-of-ethnicity-gender-age-of-onset-and-outcome-in-south-africans-with-systemic-lupus-erythematosus
#8
A Budhoo, G M Mody, T Dubula, N Patel, P G Mody
Ethnicity, gender and age of onset are reported to influence the expression and outcome of systemic lupus erythematosus. We studied a multi-ethnic cohort of 408 South Africans (91.2% females) comprising 237 (58.1%) Indians, 137 (33.6%) African Blacks, 17 (4.2%) Mixed ethnicity and 17 (4.2%) Whites. The most common manifestations were arthritis (80.6%), photosensitivity (67.2%), oral ulcers (50.0%), malar rash (49.0%) and renal (39.2%). The common laboratory findings were positive anti-nuclear factor (96.8%), haematological (74...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27836537/possible-roles-of-long-chain-sphingomyelines-and-sphingomyelin-synthase-2-in-mouse-macrophage-inflammatory-response
#9
Hideaki Sakamoto, Tetsuya Yoshida, Takao Sanaki, Shuhei Shigaki, Hirotoshi Morita, Miki Oyama, Masaru Mitsui, Yoshikazu Tanaka, Toru Nakano, Susumu Mitsutake, Yasuyuki Igarashi, Hiroshi Takemoto
To evaluate the precise role of sphingomyelin synthase 2 (SMS2) in sphingomyelin (SM) metabolism and their anti-inflammatory properties, we analyzed species of major SM and ceramide (Cer) (18:1, 18:0 sphingoid backbone, C14 - C26 N-acyl part) in SMS2 knockout and wild-type mouse plasma and liver using HPLC-MS. SMS2 deficiency significantly decreased very long chain SM (SM (d18:1/22:0) and SM (d18:1/24:0 or d18:0/24:1)) and increased very long chain Cer (Cer (d18:1/24:0 or d18:0/24:1) and Cer (d18:1/24:1)), but not long chain SM (SM (d18:1/16:0), SM (d18:1/18:0 or d18:0/18:1) and SM (d18:1/18:1)) in plasma...
November 9, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27819008/link-polymorphism-of-5-htt-promoter-region-is-associated-with-autoantibodies-in-patients-with-systemic-lupus-erythematosus
#10
Shu Li, Shuang Liu, Fan Chen, Yuqi Cheng, Ru Bai, Aiyun Lai, Zhaoping Lu, Jian Xu
Serotonin transporter linked polymorphic region (5-HTTLPR) was reported to associate with depression in systemic lupus erythematosus (SLE) patients by our team. To explore whether 5-HTTLPR plays a role in the pathogenesis of SLE, we tested 138 SLE patients and 138 age and sex matched health controls (HCs) for 5-HTTLPR by polymerase chain reaction (PCR) and agarose gel electrophoresis. Interestingly, the results suggest that the frequencies of SS genotype and S allele in SLE patients with positive anti-Sm antibody and anti-U1RNP antibody were both significantly higher than the other genotypes and alleles...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27810925/cd72-negatively-regulates-b-lymphocyte-responses-to-the-lupus-related-endogenous-toll-like-receptor-7-ligand-sm-rnp
#11
Chizuru Akatsu, Kenro Shinagawa, Nobutaka Numoto, Zhihong Liu, Ayse Konuskan Ucar, Mohammad Aslam, Shirly Phoon, Takahiro Adachi, Koji Furukawa, Nobutoshi Ito, Takeshi Tsubata
Toll-like receptor 7 (TLR7) plays an essential role in development of systemic lupus erythematosus by co-stimulating B cells reactive to the endogenous TLR7 ligand Sm/ribonucleoprotein (RNP), a crucial lupus self-antigen. However, how the TLR7-mediated autoimmune response is regulated is not yet known. In this study, we demonstrate that CD72, an inhibitory B cell co-receptor known to prevent development of lupus, recognizes Sm/RNP at the extracellular C-type lectin-like domain (CTLD) and specifically inhibits B cell response to Sm/RNP...
November 14, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27807472/oxidative-stress-and-salvia-miltiorrhiza-in-aging-associated-cardiovascular-diseases
#12
REVIEW
Cheng-Chieh Chang, Yu-Chun Chang, Wen-Long Hu, Yu-Chiang Hung
Aging-associated cardiovascular diseases (CVDs) have some risk factors that are closely related to oxidative stress. Salvia miltiorrhiza (SM) has been used commonly to treat CVDs for hundreds of years in the Chinese community. We aimed to explore the effects of SM on oxidative stress in aging-associated CVDs. Through literature searches using Medicine, PubMed, EMBASE, Cochrane library, CINAHL, and Scopus databases, we found that SM not only possesses antioxidant, antiapoptotic, and anti-inflammatory effects but also exerts angiogenic and cardioprotective activities...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27789327/chronic-administration-of-ethanol-leaf-extract-of-moringa-oleifera-lam-moringaceae-may-compromise-glycaemic-efficacy-of-sitagliptin-with-no-significant-effect-in-retinopathy-in-a-diabetic-rat-model
#13
Comfort Olurishe, Helen Kwanashie, Abdulkadiri Zezi, Nuhu Danjuma, Bisalla Mohammed
ETHNOPHARMACOLOGICAL RELEVANCE: Moringa oleifera Lam. (Moringaceae) has gained awareness for its antidiabetic effect, and is used as alternative therapy or concurrently with orthodox medicines such as sitagliptin in diabetes mellitus. This is without ascertaining the possibility of drug-herb interactions, which could either lead to enhanced antidiabetic efficacy, increased toxicity, or compromised glycaemic control with negative consequence in diabetic retinopathy. AIM OF THE STUDY: To investigate the effect, of sitagliptin (50mg/kg), Moringa oleifera (300mg/kg) leaf extract, and a combination of both on glycaemic control parameters, lenticular opacity and changes in retinal microvasculature in alloxan (150mg/kg i...
October 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27788010/resveratrol-interaction-with-lipid-bilayers-a-synchrotron-x-ray-scattering-study
#14
Ana Rute Neves, Cláudia Nunes, Heinz Amenitsch, Salette Reis
Resveratrol belongs to the large group of biologically active polyphenol compounds with several health beneficial effects including anti-oxidant activity, anti-inflammatory action, cardiovascular protection, neuroprotection and cancer chemoprevention. In the present study it is raised the possibility that the effects of resveratrol described above are caused by resveratrol membrane interactions and structural modifications of lipid bilayers. In this context, it is possible that resveratrol interacts selectively with lipid domains present in biological membranes, thereby modulating the localization of the anchored proteins and controlling their intracellular cascades...
October 27, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27783388/innate-and-humoral-recognition-of-the-products-of-cell-death-differential-antigenecity-and-immunogenecity-in-lupus
#15
Pooja Arora, Monika Malik, Ruchi Sachdeva, Latika Saxena, Joy Das, Vishnampettai G Ramachandran, Rahul Pal
While apoptotic debris is believed to constitute the original antigenic insult in lupus (which is characterized by a time-dependent diversification of autoreactivity), whether such debris and autoantibodies specifically recognizing its constituents, mediate differential effects on innate and humoral responses in lupus-prone mice is currently unknown. Apoptotic blebs (as opposed to cellular lysate), preferentially enhanced the maturation of dendritic cells (DCs) from bone marrow precursors drawn from lupus-prone mice...
October 26, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27774903/sulfur-mustard-induced-ocular-injuries-update-on-mechanisms-and-management
#16
Yunes Panahi, Danial Roshandel, Mohammad Mehdi Sadoughi, Mostafa Ghanei, Amirhossein Sahebkar
Sulfur mustard (SM; mustard gas) is a classic chemical warfare agent that has been used in several wars and is still a potential threat especially in the Middle-East region. Victims experience acute symptoms in air-exposed organs including skin, respiratory tract and the eyes. Survivors of the acute stage might develop chronic or delayed-onset complications in the exposed organs. The exact mechanism(s) of SM-induced tissue damage is still unknown, however DNA alkylation and oxidative damage are the most relevant mechanisms...
October 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27773760/preferential-expression-of-domain-cassettes-4-8-and-13-of-plasmodium-falciparum-erythrocyte-membrane-protein-1-in-severe-malaria-imported-in-france
#17
N Argy, G I Bertin, J Milet, V Hubert, J Clain, S Cojean, P Houzé, N Tuikue-Ndam, E Kendjo, P Deloron, S Houzé
OBJECTIVES: Severe Plasmodium falciparum malaria (SM) involves cytoadhesion of parasitized red blood cells, mediated by P. falciparum erythrocyte membrane protein 1, which is encoded by var genes. Expression of var gene group A and B or encoding domain cassettes DC4, DC5, DC8 and DC13 has been implicated in SM in African children, but no data exist in the context of imported malaria. The aim of this study was to investigate var gene expression linked to clinical presentation and host factors in SM imported into France...
October 20, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27762455/systemic-mastocytosis-in-adults-2017-update-on-diagnosis-risk-stratification-and-management
#18
Animesh Pardanani
: Disease overview:Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in one or more extra-cutaneous organs. DIAGNOSIS: The major criterion is presence of multifocal clusters of morphologically abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase level, abnormal MC expression of CD25 and/or CD2, and presence of KITD816V. Risk stratification: The 2008 World Health Organization (WHO) classification of SM has been shown to be prognostically relevant...
November 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27692000/frequency-of-autoimmune-disorders-and-autoantibodies-in-patients-with-neuromyelitis-optica
#19
Wildéa Lice de Carvalho Jennings Pereira, Edna Maria Vissoci Reiche, Ana Paula Kallaur, Sayonara Rangel Oliveira, Andréa Name Colado Simão, Marcell Alysson Batisti Lozovoy, Lucas José Vaz Schiavão, Paula Raquel do Vale Pascoal Rodrigues, Daniela Frizon Alfieri, Tamires Flauzino, Damacio Ramón Kaimen-Maciel
OBJECTIVE: The aim of this study was to report the frequency of autoimmune disorders and autoantibodies in 22 patients with neuromyelitis optica (NMO), as well as whether the seropositivity for autoantibodies differs between anti-aquaporin 4 (AQP4) positive and AQP4 negative NMO patients. METHODS: Demographic, medical records, and a profile of autoantibodies were evaluated in 22 NMO patients, including AQP4, anti-thyroid-stimulating hormone receptor, antinuclear antibodies (ANA), anti-thyroperoxidase (anti-TPO), anti-thyroglobulin (anti-Tg), anti-double-stranded DNA, anti-neutrophil cytoplasmic, anti-cyclic citrullinate peptide, rheumatoid factor, anti-SSA/Ro, anti-SSB/La, anti-Smith antibodies (anti-Sm), anti-ribonucleoprotein, anti-nucleosome, and anti-Scl70...
October 3, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27639157/prevalence-and-predictors-of-valvular-heart-disease-in-patients-with-systemic-lupus-erythematosus
#20
Florencia Vivero, Cristina Gonzalez-Echavarri, Beatriz Ruiz-Estevez, Irene Maderuelo, Guillermo Ruiz-Irastorza
OBJECTIVES: We aimed to study the frequency, severity and predictors of valvular heart disease (VHD) in our lupus cohort. MATERIAL AND METHODS: 211 patients were included. A transthoracic echocardiogram was used for this study. Significant valvular lesions were classified into two groups: valvular thickening and valvular dysfunction. Univariate logistic regression was performed in order to find associations with valvular thickening and dysfunction. Those variables with a p value ≤0...
September 15, 2016: Autoimmunity Reviews
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