keyword
MENU ▼
Read by QxMD icon Read
search

dohad

keyword
https://www.readbyqxmd.com/read/28301842/early-life-nutritional-programming-of-health-and-disease-in-the-gambia
#1
Sophie E Moore
BACKGROUND: Exposures during early life are increasingly being recognised as factors that play an important role in the aetiology of chronic non-communicable diseases (NCDs). The "Developmental Origins of Health and Disease" (DOHaD) hypothesis asserts that adverse early-life exposures - most notably unbalanced nutrition - leads to an increased risk for a range of NCDs and that disease risk is highest when there is a "mismatch" between the early- and later-life environments. Thus, the DOHaD hypothesis would predict highest risk in settings undergoing a rapid nutrition transition...
March 17, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28212315/developmental-programming-of-adult-disease-reprogramming-by-melatonin
#2
REVIEW
You-Lin Tain, Li-Tung Huang, Chien-Ning Hsu
Adult-onset chronic non-communicable diseases (NCDs) can originate from early life through so-called the "developmental origins of health and disease" (DOHaD) or "developmental programming". The DOHaD concept offers the "reprogramming" strategy to shift the treatment from adulthood to early life, before clinical disease is apparent. Melatonin, an endogenous indoleamine produced by the pineal gland, has pleiotropic bioactivities those are beneficial in a variety of human diseases. Emerging evidence support that melatonin is closely inter-related to other proposed mechanisms contributing to the developmental programming of a variety of chronic NCDs...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28209604/birth-size-risk-factors-across-life-and-cognition-in-late-life-protocol-of-prospective-longitudinal-follow-up-of-the-mynah-mysore-studies-of-natal-effects-on-ageing-and-health-cohort
#3
Murali Krishna, G Mohan Kumar, S R Veena, G V Krishnaveni, Kalyanaraman Kumaran, Samuel Christaprasad Karat, Patsy Coakley, Clive Osmond, John R M Copeland, Giriraj Chandak, Dattatray Bhat, Mathew Varghese, Martin Prince, Caroline Fall
INTRODUCTION: For late-life neurocognitive disorders, as for other late-life chronic diseases, much recent interest has focused on the possible relevance of Developmental Origins of Health and Disease (DOHaD). Programming by undernutrition in utero, followed by overnutrition in adult life may lead to an increased risk, possibly mediated through cardiovascular and metabolic pathways. This study will specifically examine, if lower birth weight is associated with poorer cognitive functioning in late life in a south Indian population...
February 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28208659/developmental-origins-of-chronic-kidney-disease-should-we-focus-on-early-life
#4
REVIEW
You-Lin Tain, Chien-Ning Hsu
Chronic kidney disease (CKD) is becoming a global burden, despite recent advances in management. CKD can begin in early life by so-called "developmental programming" or "developmental origins of health and disease" (DOHaD). Early-life insults cause structural and functional changes in the developing kidney, which is called renal programming. Epidemiological and experimental evidence supports the proposition that early-life adverse events lead to renal programming and make subjects vulnerable to developing CKD and its comorbidities in later life...
February 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28196555/dohad-at-the-intersection-of-maternal-immune-activation-and-maternal-metabolic-stress-a-scoping-review
#5
J A Goldstein, S A Norris, D M Aronoff
The prenatal environment is now recognized as a key driver of non-communicable disease risk later in life. Within the developmental origins of health and disease (DOHaD) paradigm, studies are increasingly identifying links between maternal morbidity during pregnancy and disease later in life for offspring. Nutrient restriction, metabolic disorders during gestation, such as diabetes or obesity, and maternal immune activation provoked by infection have been linked to adverse health outcomes for offspring later in life...
February 15, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28169463/relationship-between-epigenetic-regulation-dietary-habits-and-the-developmental-origins-of-health-and-disease-theory
#6
REVIEW
Kazuki Mochizuki, Natsuyo Hariya, Kazue Honma, Toshinao Goda
Environmental stressors during developmental stages are hypothesized to increase the risk of developing metabolic diseases such as obesity, type 2 diabetes, hypertension, and psychiatric diseases during later life. This theory is known as the Developmental Origins of Health and Disease (DOHaD). Recent studies suggest that accumulation of environmental stress, including during developmental stages, is internalized as acquired information designated as "epigenetic memory." This epigenetic memory is generally indicated as DNA methylation and histone modifications in the chromatin...
February 7, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28165368/reducing-low-birth-weight-among-african-americans-in-the-midwest-a-look-at-how-faith-based-organizations-are-poised-to-inform-and-influence-health-communication-on-the-developmental-origins-of-health-and-disease-dohad
#7
Crystal Y Lumpkins, Jarron M Saint Onge
Low birth weight (LBW) rates remain the highest among African Americans despite public health efforts to address these disparities; with some of the highest racial disparities in the Midwest (Kansas). The Developmental Origins of Health and Disease (DOHaD) perspective offers an explanation for how LBW contributes to racial health disparities among African Americans and informs a community directed health communication framework for creating sustainable programs to address these disparities. Trusted community organizations such as faith-based organizations are well situated to explain health communication gaps that may occur over the life course...
February 4, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/27918455/targeting-on-asymmetric-dimethylarginine-related-nitric-oxide-reactive-oxygen-species-imbalance-to-reprogram-the-development-of-hypertension
#8
REVIEW
You-Lin Tain, Chien-Ning Hsu
Adult-onset diseases, including hypertension, can originate from early life, known as the developmental origins of health and disease (DOHaD). Because the developing kidney is vulnerable to early-life insults, renal programming is considered key in the developmental programming of hypertension. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, can regulate the NO-reactive oxygen species (ROS) balance, and is involved in the development of hypertension. Reprogramming interventions aimed at NO-ROS balance can be protective in both genetic and developmentally programmed hypertension...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27897982/maternal-fructose-intake-affects-transcriptome-changes-and-programmed-hypertension-in-offspring-in-later-life
#9
REVIEW
You-Lin Tain, Julie Y H Chan, Chien-Ning Hsu
Hypertension originates from early-life insults by so-called "developmental origins of health and disease" (DOHaD). Studies performed in the previous few decades indicate that fructose consumption is associated with an increase in hypertension rate. It is emerging field that tends to unfold the nutrient-gene interactions of maternal high-fructose (HF) intake on the offspring which links renal programming to programmed hypertension. Reprogramming interventions counteract disturbed nutrient-gene interactions induced by maternal HF intake and exert protective effects against developmentally programmed hypertension...
November 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27880687/commentary-developing-the-future-life-course-epidemiology-dohad-and-evolutionary-medicine
#10
Mark Hanson, Peter Gluckman
No abstract text is available yet for this article.
August 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27871864/review-of-developmental-origins-of-health-and-disease-publications-in-environmental-epidemiology
#11
Jerrold J Heindel, Lesley A Skalla, Bonnie R Joubert, Caroline H Dilworth, Kimberly A Gray
The Developmental Origins of Health and Disease (DOHaD) scientific field investigates the influence of early life environmental stressors on later life health outcomes. Environmental chemical exposures are a particular focus area within this field. Although the DOHaD hypothesis originated in the 1990s, the data evaluating this hypothesis in environmental epidemiology has not been comprehensively summarized. We conducted a scoping literature review to describe the human evidence for the DOHaD hypothesis and to identify, 1) where there may be reasonable data to draw conclusions, and 2) areas warranting further research...
November 18, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27845744/promoting-healthy-growth-or-feeding-obesity-the-need-for-evidence-based-oversight-of-infant-nutritional-supplement-claims
#12
Michelle Lampl, Amanda Mummert, Meriah Schoen
The Developmental Origins of Health and Disease (DOHaD) model recognizes growth in infancy and childhood as a fundamental determinant of lifespan health. Evidence of long-term health risks among small neonates who subsequently grow rapidly poses a challenge for interventions aiming to support healthy growth, not merely drive weight gain. Defining healthy growth beyond "getting bigger" is essential as infant and young child feeding industries expand. Liquid-based nutritional supplements, originally formulated for undernourished children, are increasingly marketed for and consumed by children generally...
November 12, 2016: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/27834861/the-implications-of-the-developmental-origins-of-health-and-disease-on-public-health-policy-and-health-promotion-in-south-africa
#13
REVIEW
Sasiragha Priscilla Reddy, Anthony David Mbewu
The developmental origins of health and disease (DOHaD) hypothesis states that environmental influences in utero and in early life can determine health and disease in later life through the programming of genes and/or altered gene expression. The DOHaD is likely to have had an effect in South Africa during the fifty years of apartheid; and during the twenty years since the dawn of democracy in 1994. This has profound implications for public health and health promotion policies in South Africa, a country experiencing increased prevalence of noncommunicable diseases (NCDs) and risk factors and behaviours for NCDs due to rapid social and economic transition, and because of the DOHaD...
November 9, 2016: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/27827896/transforming-life-a-broad-view-of-the-developmental-origins-of-health-and-disease-concept-from-an-ecological-justice-perspective
#14
Susan L Prescott, Alan C Logan
The influential scientist Rene J. Dubos (1901-1982) conducted groundbreaking studies concerning early-life environmental exposures (e.g., diet, social interactions, commensal microbiota, housing conditions) and adult disease. However, Dubos looked beyond the scientific focus on disease, arguing that "mere survival is not enough". He defined mental health as fulfilling human potential, and expressed concerns about urbanization occurring in tandem with disappearing access to natural environments (and elements found within them); thus modernity could interfere with health via "missing exposures"...
November 3, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27827847/programmed-effects-in-neurobehavior-and-antioxidative-physiology-in-zebrafish-embryonically-exposed-to-cadmium-observations-and-hypothesized-adverse-outcome-pathway-framework
#15
Sander Ruiter, Josefine Sippel, Manon C Bouwmeester, Tobias Lommelaars, Piet Beekhof, Hennie M Hodemaekers, Frank Bakker, Evert-Jan van den Brandhof, Jeroen L A Pennings, Leo T M van der Ven
Non-communicable diseases (NCDs) are a major cause of premature mortality. Recent studies show that predispositions for NCDs may arise from early-life exposure to low concentrations of environmental contaminants. This developmental origins of health and disease (DOHaD) paradigm suggests that programming of an embryo can be disrupted, changing the homeostatic set point of biological functions. Epigenetic alterations are a possible underlying mechanism. Here, we investigated the DOHaD paradigm by exposing zebrafish to subtoxic concentrations of the ubiquitous contaminant cadmium during embryogenesis, followed by growth under normal conditions...
November 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27801895/prenatal-maternal-depression-is-associated-with-offspring-inflammation-at-25-years-a-prospective-longitudinal-cohort-study
#16
D T Plant, S Pawlby, D Sharp, P A Zunszain, C M Pariante
Animal studies and a handful of prospective human studies have demonstrated that young offspring exposed to maternal prenatal stress show abnormalities in immune parameters and hypothalamic-pituitary-adrenal (HPA) axis function. No study has examined the effect of maternal prenatal depression on offspring inflammation and HPA axis activity in adulthood, nor the putative role of child maltreatment in inducing these abnormalities. High-sensitivity C-reactive protein (hs-CRP) and awakening cortisol were measured at age 25 in 103 young-adult offspring of the South London Child Development Study (SLCDS), a prospective longitudinal birth cohort of mother-offspring dyads recruited in pregnancy in 1986...
November 1, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27774781/fetal-programming-of-neuropsychiatric-disorders
#17
REVIEW
Gavino Faa, Mirko Manchia, Roberta Pintus, Clara Gerosa, Maria Antonietta Marcialis, Vassilios Fanos
Starting from the Developmental Origins of Health and Disease (DOHaD) hypotheses proposed by David Barker, namely fetal programming, in the past years, there is a growing evidence of the major role played by epigenetic factors during the intrauterine life and the perinatal period. Furthermore, it has been assessed that these factors can affect the health status in infancy and even in adulthood. In this review, we focus our attention on the fetal programming of the brain, analyzing the most recent literature concerning the epigenetic factors that can influence the development of neuropsychiatric disorders such as bipolar disorders, major depressive disorders, and schizophrenia...
September 2016: Birth Defects Research. Part C, Embryo Today: Reviews
https://www.readbyqxmd.com/read/27774366/differential-response-of-human-embryonic-stem-and-somatic-cells-to-non-cytotoxic-hydrogen-peroxide-exposure-an-attempt-to-model-in-vitro-the-effects-of-oxidative-stress-on-the-early-embryo
#18
M Barandalla, S Colleoni, G Lazzari
Human Embryonic Stem Cells (hESCs) potentially offer a unique in vitro model to study how an adverse environment during the early developmental stages post-fertilization can affect the physiology of the undifferentiated embryonic stem cells existing in the early embryo and predispose to long term effects on the offspring, according to the Developmental Origins of Health and Disease (DOHaD) concept. A number of unfavourable conditions can affect the development of the early embryo inducing oxidative stress both in vivo, for instance in gestational diabetes and in vitro, when embryos are derived from Assisted Reproductive Technologies (ART)...
August 2016: Cell & Developmental Biology
https://www.readbyqxmd.com/read/27757222/in-utero-origin-of-sex-related-differences-in-future-cardiovascular-disease
#19
Sarah Schalekamp-Timmermans, Jerome Cornette, Albert Hofman, Willem A Helbing, Vincent W V Jaddoe, Eric A P Steegers, Bero O Verburg
BACKGROUND: There are sex differences in the risk of development of cardiovascular disease (CVD). According to the developmental origins of health and disease paradigm (DOHaD), CVD originates in fetal life. This study examines fetal sex differences in cardiovascular development in utero. METHODS: In 1028 pregnant women, we assessed fetal circulation using pulsed wave Doppler examinations between 28 and 34 weeks gestation. To test associations between fetal sex and fetal circulation measurements, linear regression models were used adjusting for fetal size, gestational age, and fetal heart rate...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27729090/extending-the-developmental-origins-of-health-and-disease-theory-does-paternal-diet-contribute-to-breast-cancer-risk-in-daughters
#20
Stephanie Romanus, Patrick Neven, Adelheid Soubry
The Developmental Origins of Health and Disease (DOHaD) theory focuses on the consequences of periconceptional and in utero exposures. A wide range of environmental conditions during early development are now being investigated as a driving force for epigenetic disruptions that enhance disease risk in later life, including cardiovascular, metabolic, endocrine, and mental disorders and even breast cancer. Most studies involve mother-child dyads, with less focus on environmental influences through the father...
October 12, 2016: Breast Cancer Research: BCR
keyword
keyword
63281
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"