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Nuclear magnetic resonance

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https://www.readbyqxmd.com/read/27911551/superconductivity-emerging-from-an-electronic-phase-separation-in-the-charge-ordered-phase-of-rbfe_-2-as_-2
#1
E Civardi, M Moroni, M Babij, Z Bukowski, P Carretta
^{75}As, ^{87}Rb, and ^{85}Rb nuclear quadrupole resonance (NQR) and ^{87}Rb nuclear magnetic resonance measurements in a RbFe_{2}As_{2} iron-based superconductor are presented. We observe a marked broadening of the ^{75}As NQR spectrum below T_{0}≃140  K which is associated with the onset of a charge order in the FeAs planes. Below T_{0} we observe a power-law decrease in the ^{75}As nuclear spin-lattice relaxation rate down to T^{*}≃20  K. Below T^{*} the nuclei start to probe different dynamics owing to the different local electronic configurations induced by the charge order...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27911361/spin-saturation-transfer-difference-nmr-sstd-nmr-a-new-tool-to-obtain-kinetic-parameters-of-chemical-exchange-processes
#2
María Teresa Quirós, Colin Macdonald, Jesús Angulo, María Paz Muñoz
This detailed protocol describes the new Spin Saturation Transfer Difference Nuclear Magnetic Resonance protocol (SSTD NMR), recently developed in our group to study processes of mutual-site chemical exchange that are difficult to analyze by traditional methods. As the name suggests, this method combines the Spin Saturation Transfer method used for small molecules, with the Saturation Transfer Difference (STD) NMR method employed for the study of protein-ligand interactions, by measuring transient spin saturation transfer along increasing saturation times (build-up curves) in small organic and organometallic molecules undergoing chemical exchange...
November 12, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910948/improved-in-cell-structure-determination-of-proteins-at-near-physiological-concentration
#3
Teppei Ikeya, Tomomi Hanashima, Saori Hosoya, Manato Shimazaki, Shiro Ikeda, Masaki Mishima, Peter Güntert, Yutaka Ito
Investigating three-dimensional (3D) structures of proteins in living cells by in-cell nuclear magnetic resonance (NMR) spectroscopy opens an avenue towards understanding the structural basis of their functions and physical properties under physiological conditions inside cells. In-cell NMR provides data at atomic resolution non-invasively, and has been used to detect protein-protein interactions, thermodynamics of protein stability, the behavior of intrinsically disordered proteins, etc. in cells. However, so far only a single de novo 3D protein structure could be determined based on data derived only from in-cell NMR...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910860/dynamic-nuclear-magnetic-resonance-field-sensing-with-part-per-trillion-resolution
#4
Simon Gross, Christoph Barmet, Benjamin E Dietrich, David O Brunner, Thomas Schmid, Klaas P Pruessmann
High-field magnets of up to tens of teslas in strength advance applications in physics, chemistry and the life sciences. However, progress in generating such high fields has not been matched by corresponding advances in magnetic field measurement. Based mostly on nuclear magnetic resonance, dynamic high-field magnetometry is currently limited to resolutions in the nanotesla range. Here we report a concerted approach involving tailored materials, magnetostatics and detection electronics to enhance the resolution of nuclear magnetic resonance sensing by three orders of magnitude...
December 2, 2016: Nature Communications
https://www.readbyqxmd.com/read/27910789/methoxyflavones-from-new-lingzhi-medicinal-mushroom-ganoderma-lingzhi-agaricomycetes
#5
Kuniyoshi Shimizu, Yhiya M Amen, Satoru Kaifuchi
Ganoderma lingzhi is one of the most famous medicinal fungi in the world. It has been used in folk medicine, especially in East Asian countries. It is also a white-rot fungus with strong wood degradation ability, especially against lignin. Different classes of bioactive natural products have been reported in Ganoderma, including triterpenes, polysaccharides, sterols, and peptides. The triterpenes and polysaccharides are the primary bioactive compounds of Ganoderma. We report for the first time the presence of 3 methoxyflavones as minor constituents in G...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910772/structural-characterization-and-immunological-activities-of-a-novel-water-soluble-polysaccharide-from-the-fruiting-bodies-of-culinary-medicinal-winter-mushroom-flammulina-velutipes-agaricomycetes
#6
Ting Feng, Wei Jia, Wen-Han Wang, Chi-Chung Lin, Hua Fan, Jing-Song Zhang, Hai-Ying Bao
A water-soluble polysaccharide, designated FVPA2, was isolated from the fruiting bodies of Flammulina velutipes using DEAE Sepharose Fast Flow and gel-permeation chromatography. Its structure was elucidated by monosaccharide composition and methylation analysis, ultraviolet, Fourier transform infrared spectrometry, and nuclear magnetic resonance spectroscopy. Results showed that FVPA2 was a homogeneous heteropolysaccharide containing galactose, fucose, and mannose in a molar ratio of 5:1:1. High-performance liquid chromatography indicated its molecular weight as 3...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910770/addition-of-zeolites-to-improve-the-functional-characteristics-of-the-hen-of-the-wood-or-maitake-medicinal-mushroom-grifola-frondosa-agaricomycetes
#7
Jovana Vunduk, Anita Klaus, Maja Kozarski, Radovan Dordevic, Zoran Miladinovic, Ljubinko Jovanovic, Miomir Niksic, Leonardus Johannes Lambertus Donatus Van Griensven
Kaolinite and the modified natural zeolite minazel plus (M+) were used as supplements in substrate used for the production of the medicinal mushroom Grifola frondosa. Growth stimulation, expressed as yield and biological efficiency, was observed when M+ (1%) was added. The production cycle was shortened by half as a result of the zeolites' ion-exchange ability, stimulation of enzyme activity, and water retain capacity. Inductively coupled plasma optical emission spectrometry of fruiting bodies showed the absence of heavy metals (arsenic, cadmium, and lead), whereas the concentration of calcium increased greatly and the concentrations of iron, magnesium, and zinc increased moderately under the influence of M+...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910757/free-radical-scavenging-activities-of-cultured-mycelia-of-paecilomyces-hepiali-ascomycetes-extracts-and-structural-characterization-of-bioactive-components-by-nuclear-magnetic-resonance-spectroscopy
#8
Lucia Ungvarska Mal'ucka, Jarmila Harvanova, Martin Pavlik, Martin Rajtar, Lukas Jarosciak
Current research is focused on testing the cultivation of Paecilomyces hepiali mycelia on various plant substrates and producing fungus or mycelial biomass with qualitatively interesting substances. P. hepiali mycelia was cultivated using solid-state fermentation of different substrates. Mycelial biomass was then analyzed, and antioxidant activity was evaluated using the DPPH radical scavenging method for different ethanolic extracts based on a millet substrate (extract 1) or a chickpea substrate (extract 2)...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27909808/clinical-validation-of-a-novel-urine-based-metabolomic-test-for-the-detection-of-colonic-polyps-on-chinese-population
#9
Lu Deng, Hong Fang, Victor K Tso, Yuanyuan Sun, Rae R Foshaug, Spencer C Krahn, Fen Zhang, Yujie Yan, Huilin Xu, David Chang, Yong Zhang, Richard N Fedorak
PURPOSE: Colorectal cancer is the fifth leading cause of cancer-related deaths in China. When detected early, with the removal of adenomatous polyps, precursors of colorectal cancer, it is preventable. The aim of this study was to evaluate a novel urine-based metabolomic diagnostic test for the detection of adenomatous polyps, PolypDx™, that was originally developed and validated using 1000 samples from Canadian Cohort, on Chinese population. METHODS: Prospective urine samples were collected from 1000 participants undergoing colonoscopy examination, from March 2013 to July 2014 at Minhang District, Shanghai Centre for Disease Control and Prevention...
December 1, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27908763/development-of-a-simple-proton-nuclear-magnetic-resonance-based-procedure-to-estimate-the-approximate-distribution-coefficient-at-physiological-ph-logd7-4-evaluation-and-comparison-to-existing-practices
#10
E Johanna L Stéen, Nils Nyberg, Szabolcs Lehel, Valdemar L Andersen, Pantaleo Di Pilato, Gitte M Knudsen, Jesper L Kristensen, Matthias M Herth
In drug discovery, lipophilicity is a key parameter for drug optimization. Lipophilicity determinations can be both work and time consuming, especially for non-UV active compounds. Herein, an improved and simple 1H NMR-based method is described to estimate the lipophilicity at physiological pH (logD7.4) in 1-octanol and D2O buffer. The method can be applied to both UV and non-UV active compounds. In addition, neither calibration curves nor internal/external standards are needed. We have demonstrated that logD7...
November 18, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27908513/small-bowel-imaging-computed-tomography-enterography-magnetic-resonance-enterography-angiography-and-nuclear-medicine
#11
REVIEW
Jeff L Fidler, Ajit H Goenka, Chad J Fleming, James C Andrews
Radiology examinations play a major role in the diagnosis, management, and surveillance of small bowel diseases and are complementary to endoscopic techniques. Computed tomography enterography and magnetic resonance enterography are the cross-sectional imaging studies of choice for many small bowel diseases. Angiography still plays an important role for catheter-directed therapies. With the emergence of hybrid imaging techniques, radionuclide imaging has shown promise for the evaluation of small bowel bleeding and Crohn disease and may play a larger role in the future...
January 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/27908137/chirality-sensitive-nuclear-magnetic-resonance-effects-induced-by-indirect-spin-spin-coupling
#12
P Garbacz, A D Buckingham
It is predicted that, for two spin-1/2 nuclei coupled by indirect spin-spin coupling in a chiral molecule, chirality-sensitive induced electric polarization can be observed at the frequencies equal to the sum and difference between the spin resonance frequencies. Also, an electric field oscillating at the difference frequency can induce spin coherences which allow the direct discrimination between enantiomers by nuclear magnetic resonance. The dominant contribution to the magnitude of these expected chiral effects is proportional to the permanent electric dipole moment and to the antisymmetric part of the indirect spin-spin coupling tensor of the chiral molecule...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27907858/rapid-preparation-of-branched-and-degradable-aie-active-fluorescent-organic-nanoparticles-via-formation-of-dynamic-phenyl-borate-bond
#13
Zi Long, Meiying Liu, Liucheng Mao, Guangjian Zeng, Qing Wan, Dazhuang Xu, Fengjie Deng, Hongye Huang, Xiaoyong Zhang, Yen Wei
The fluorescent organic nanoparticles (FNPs) with aggregation-induced emission (AIE) feature have received increasing attention for their advanced optical properties. Although many efforts have been devoted to the fabrication and biomedical applications of AIE-active FNPs, the preparation of branched AIE-active FNPs with degradability through formation of dynamic bonds have rarely been reported. In this work, branched AIE-active FNPs were fabricated via dynamic linkage of hydrophobic hyperbranched and degradable Boltorn H40 (H40) with phenylboronic acid terminated AIE dye (PhB(OH)2) and mPEG (mPEG-B(OH)2), which relied on a facile one-pot strategy between phenylboronic acid and diol group of H40...
November 17, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27907139/contribution-towards-a-metabolite-profile-of-the-detoxification-of-benzoic-acid-through-glycine-conjugation-an-intervention-study
#14
Cindy Irwin, Mari van Reenen, Shayne Mason, Lodewyk J Mienie, Johan A Westerhuis, Carolus J Reinecke
Benzoic acid is widely used as a preservative in food products and is detoxified in humans through glycine conjugation. Different viewpoints prevail on the physiological significance of the glycine conjugation reaction and concerns have been raised on potential public health consequences following uncontrolled benzoic acid ingestion. We performed a metabolomics study which used commercial benzoic acid containing flavored water as vehicle for designed interventions, and report here on the controlled consumption of the benzoic acid by 21 cases across 6 time points for a total of 126 time points...
2016: PloS One
https://www.readbyqxmd.com/read/27905491/changes-in-urinary-metabolomic-profile-during-relapsing-renal-vasculitis
#15
Bahjat Al-Ani, Martin Fitzpatrick, Hamad Al-Nuaimi, Alice M Coughlan, Fionnuala B Hickey, Charles D Pusey, Caroline Savage, Christopher M Benton, Eóin C O'Brien, Declan O'Toole, Ken H Mok, Stephen P Young, Mark A Little
Current biomarkers of renal disease in systemic vasculitis lack predictive value and are insensitive to early damage. To identify novel biomarkers of renal vasculitis flare, we analysed the longitudinal urinary metabolomic profile of a rat model of anti-neutrophil cytoplasmic antibody (ANCA) vasculitis. Wistar-Kyoto (WKY) rats were immunised with human myeloperoxidase (MPO). Urine was obtained at regular intervals for 181 days, after which relapse was induced by re-challenge with MPO. Urinary metabolites were assessed in an unbiased fashion using nuclear magnetic resonance (NMR) spectroscopy, and analysed using partial least squares discriminant analysis (PLS-DA) and partial least squares regression (PLS-R)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904923/can-diffusion-weighted-magnetic-resonance-imaging-of-clear-cell-renal-carcinoma-predict-low-from-high-nuclear-grade-tumors
#16
Carolina Parada Villavicencio, Robert J Mc Carthy, Frank H Miller
OBJECTIVE: To assess the diagnostic performance of the apparent diffusion coefficient (ADC) in predicting the Fuhrman nuclear grading of clear cell renal cell carcinomas (ccRCC). MATERIALS AND METHODS: A total of 129 patients who underwent partial and radical nephrectomies with pathology-proven ccRCC were retrospectively evaluated. Histopathological characteristics and nuclear grades were analyzed. In addition, conventional magnetic resonance imaging (MRI) features were assessed in consensus by two radiologists to discriminate nuclear grading...
December 1, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27904250/diagnosis-and-management-of-postoperative-biliary-leaks
#17
REVIEW
Arian M Nikpour, R Justin Knebel, Danny Cheng
Postoperative biliary leaks have become more common in the past three decades since the development of laparoscopic biliary surgery. The role of the radiologist and interventional radiologist is important in the diagnosis and treatment of such complications, and can play an adjunctive role in the definitive surgical repair. Ultrasound, computed tomography, magnetic resonance cholangiopancreatography, nuclear medicine cholescintigraphy studies, and percutaneous transhepatic cholangiograms (PTC) are the various imaging modalities used for diagnosis...
December 2016: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/27904246/noninvasive-imaging-of-the-biliary-system-relevant-to-percutaneous-interventions
#18
REVIEW
Stephen Thomas, Kayleen Jahangir
Clinical data such as history, physical examination, and laboratory tests are useful in identifying patients with biliary obstruction and biliary sources of infection. However, if intervention is planned, noninvasive imaging is needed to confirm the presence, location, and extent of the disease process. Currently, the most commonly available and used noninvasive modalities are ultrasound (US), computed tomography (CT), magnetic resonance (MR), and nuclear medicine hepatobiliary scintigraphy (HIDA). US is quick, portable, readily available, and is commonly the first imaging modality used when biliary pathology is suspected...
December 2016: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/27903443/biochemical-and-genetic-basis-of-orsellinic-acid-biosynthesis-and-prenylation-in-a-stereaceous-basidiomycete
#19
Jana Braesel, Janis Fricke, Daniel Schwenk, Dirk Hoffmeister
The prenylphenols are a class of natural products that have been frequently isolated from basidiomycetes, e.g., from the genus Stereum (false turkey tail fungi) and other Russulales as well as from ascomycetes. Biosynthetically, these compounds are considered hybrids, as the orsellinic acid moiety is a polyketide and the prenyl side chain originates from the terpene metabolism, although no literature on the genetic and biochemical background of the biosynthesis is available. In a stereaceous basidiomycete, referred to as BY1, a new prenylphenol, now termed cloquetin, was identified and its structure elucidated by mass spectrometry and nuclear magnetic resonance spectroscopy...
November 26, 2016: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/27902713/association-of-n-linked-glycoprotein-acetyls-and-colorectal-cancer-incidence-and-mortality
#20
Paulette D Chandler, Akintunde O Akinkuolie, Deirdre K Tobias, Patrick R Lawler, Chungying Li, M Vinayaga Moorthy, Lu Wang, Daniel A Duprez, David R Jacobs, Robert J Glynn, James Otvos, Margery A Connelly, Wendy S Post, Paul M Ridker, JoAnn E Manson, Julie E Buring, I-Min Lee, Samia Mora
BACKGROUND: Acute phase proteins highlight the dynamic interaction between inflammation and oncogenesis. GlycA, a novel nuclear magnetic resonance (NMR) inflammatory marker that identifies primarily circulating N-acetyl glycan groups attached to acute phase proteins, may be a future CRC risk biomarker. METHODS: We examined the association between GlycA and incident CRC and mortality in two prospective cohorts (N = 34,320); Discovery cohort: 27,495 participants from Women's Health Study (WHS); Replication cohort: 6,784 participants from Multi-Ethnic Study of Atherosclerosis (MESA)...
2016: PloS One
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