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Nuclear magnetic resonance

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https://www.readbyqxmd.com/read/28545259/identification-of-diacetonamine-from-soybean-curd-residue-as-a-sporulation-inducing-factor-toward-bacillus-spp
#1
Aki Ikeda, Dongyeop Kim, Yasuyuki Hashidoko
Under bioassay-guided investigation, a sporulation-inducing factor (SIF) toward Bacillus spp. was searched for in methanol (MeOH) extracts of soybean curd residues, and diacetonamine (1) was identified as the active compound. SIF was first isolated as a monoacetylated derivative (2, 4.1 mg from 655 g soybean curd residues), and its chemical structure was elucidated by field desorption mass spectrometry, electron ionization mass spectrometry, and nuclear magnetic resonance (NMR) analyses. After 48-h incubation, 40 µM diacetonamine hydrochloride (1b) exhibited sporulation-inducing activity with 35% sporulation frequency toward a Bacillus amyloliquefaciens wild-type strain (AHU 2170), whereas 40 µM diacetone acrylamide (3) showed 99% sporulation induction, which was much higher than that of 1b...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28544938/sex-steroids-and-metabolic-responses-in-mussels-mytilus-galloprovincialis-exposed-to-drospirenone
#2
Tiziana Cappello, Denise Fernandes, Maria Maisano, Andrea Casano, Marta Bonastre, Maria João Bebianno, Angela Mauceri, Salvatore Fasulo, Cinta Porte
Drospirenone (DRO) is a synthetic progestin derived from 17α-spironolactone with a pharmacological mechanism of action similar to progesterone. Despite its wide use as pharmaceutical and consequent continuous release into the aquatic environment, DRO effects have been poorly investigated on aquatic biota. In order to unravel the toxicity mechanisms of DRO, mussels Mytilus galloprovincialis were exposed for 7 days to different concentrations of DRO, namely 20ng/L (Low; L), 200ng/L (Medium; M), 2000ng/L (High; H) and 10μg/L (Super High; SH) nominal doses...
May 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28544035/chemical-exchange-sensitive-mri-of-amide-amine-and-noe-at-9-4%C3%A2-t-versus-15-2%C3%A2-t
#3
Julius Juhyun Chung, Wonmin Choi, Tao Jin, Jung Hee Lee, Seong-Gi Kim
Chemical exchange (CE)-sensitive MRI benefits greatly from stronger magnetic fields; however, field effects on CE-sensitive imaging have not yet been studied well in vivo. We have compared CE-sensitive Z-spectra and maps obtained at the fields of 9.4 T and 15.2 T in phantoms and rats with off-resonance chemical-exchange-sensitive spin lock (CESL), which is similar to conventional chemical exchange saturation transfer. At higher fields, the background peak at water resonance has less spread and the exchange rate relative to chemical shift decreases, thus CESL intensity is dependent on B0 ...
May 22, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28542375/human-plasma-metabolomics-in-age-related-macular-degeneration-amd-using-nuclear-magnetic-resonance-spectroscopy
#4
Inês Laíns, Daniela Duarte, António S Barros, Ana Sofia Martins, João Gil, John B Miller, Marco Marques, Tânia Mesquita, Ivana K Kim, Maria da Luz Cachulo, Demetrios Vavvas, Isabel M Carreira, Joaquim N Murta, Rufino Silva, Joan W Miller, Deeba Husain, Ana M Gil
PURPOSE: To differentiate the plasma metabolomic profile of patients with age related macular degeneration (AMD) from that of controls, by Nuclear Magnetic Resonance (NMR) spectroscopy. METHODS: Two cohorts (total of 396 subjects) representative of central Portugal and Boston, USA phenotypes were studied. For each cohort, subjects were grouped according to AMD stage (early, intermediate and late). Multivariate analysis of plasma NMR spectra was performed, followed by signal integration and univariate analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28539719/ultrasound-assisted-extraction-of-ursolic-acid-from-the-flowers-of-ixora-coccinia-linn-rubiaceae-and-antiproliferative-activity-of-ursolic-acid-and-synthesized-derivatives
#5
Silvana Amadeu Ferreira Alves Monteath, Maria Aparecida M Maciel, Raquel Garcia Vega, Heloisa de Mello, Carollina de Araújo Martins, Andressa Esteves-Souza, Cerli Rocha Gattass, Aurea Echevarria
BACKGROUND: Ixora coccinea Linn (Rubiaceae) is an evergreen shrub with bright scarlet colored flowers found in several tropical and subtropical countries. It is used as an ornamental and medicinal plant. Phytochemical studies revealed that its major special metabolites are triterpene acids, such as ursolic and oleanolic acid. OBJECTIVE: To evaluate the isolation of ursolic acid (UA) (1) from methanol extracts of I. coccinea flowers through two methodologies, to prepare four derivatives, and to evaluate the cytotoxic effect against six cancer cell lines...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28539711/flavonoids-isolated-from-the-flowers-of-limonium-bicolor-and-their-in-vitro-antitumor-evaluation
#6
Jian Chen, Jiehui Teng, Li Ma, Haiying Tong, Bingru Ren, Linshan Wang, Weilin Li
BACKGROUND: Limonium bicolor, a halophytic species, can grow in saline or saline-alkali soil, is well known as a traditional Chinese medicine. Recently it attracted much attention for its treatment for cancer. OBJECTIVE: The present study was performed to evaluate this species from the phytochemical standpoint and the possible relationship between the antitumor activity and its natural products. MATERIALS AND METHODS: The chemical constituents from the flowers of L...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28539640/recalcitrant-carbon-components-in-glomalin-related-soil-protein-facilitate-soil-organic-carbon-preservation-in-tropical-forests
#7
Jing Zhang, Xuli Tang, Siyuan Zhong, Guangcai Yin, Yifei Gao, Xinhua He
Glomalin-related soil protein (GRSP) is known as an important microbial by-product which is crucial for preserving or accumulating soil organic carbon (SOC). However, the underlying mechanisms are not well understood. In this study, we investigated the chemical structures of GRSP and its relationship with SOC using (13)C nuclear magnetic resonance (NMR) in three tropical forests. The three forests, including a planted forest (PF), a secondary forest (MF) and a primary forest (BF), were selected to represent the natural successional process after disturbance in southern China...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28538613/acute-retinal-damage-after-using-a-toxic-perfluoro-octane-for-vitreo-retinal-surgery
#8
J Carlos Pastor, Rosa M Coco, Ivan Fernandez-Bueno, Maria L Alonso-Alonso, Jesús Medina, Aurelio Sanz-Arranz, Fernando Rull, Manuel J Gayoso, Antonio Dueñas, Maria T Garcia-Gutierrez, Lucia Gonzalez-Buendia, Santiago Delgado-Tirado, Emilio Abecia, Miguel Ruiz-Miguel, Miguel A Serrano, Jose M Ruiz-Moreno, Girish K Srivastava
PURPOSE: To describe a series of retinal acute toxicity cases with severe visual loss after intraocular use of a toxic perfluoro-octane (PFO). The clinical presentation is described, and the likely causes are analyzed. New biological methods for testing safety of intraocular medical devices are proposed. METHODS: Information regarding a series of eyes suffering acute severe events after intraocular use of a toxic PFO was analyzed. Four types of spectroscopy, nuclear magnetic resonance, and chromatography were used to identify the potential PFO contaminants...
June 2017: Retina
https://www.readbyqxmd.com/read/28538152/apoptotic-bax-at-oxidatively-stressed-mitochondrial-membranes-lipid-dynamics-and-permeabilization
#9
Artur Peter Günther Dingeldein, Šárka Pokorná, Martin Lidman, Tobias Sparrman, Radek Šachl, Martin Hof, Gerhard Gröbner
Mitochondria are crucial compartments of eukaryotic cells because they function as the cellular power plant and play a central role in the early stages of programmed cell death (apoptosis). To avoid undesired cell death, this apoptotic pathway is tightly regulated by members of the Bcl-2 protein family, which interact on the external surface of the mitochondria, i.e., the mitochondrial outer membrane (MOM), and modulate its permeability to apoptotic factors, controlling their release into the cytosol. A growing body of evidence suggests that the MOM lipids play active roles in this permeabilization process...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28537726/hot-spotting-with-thermal-scanning-a-ligand-and-structure-independent-assessment-of-target-ligandability
#10
Molly Chilton, Ben Clennell, Fredrik Edfeldt, Stefan Geschwindner
Evaluating the ligandability of a protein target is a key component when defining hit-finding strategies or to prioritize amongst drug targets. Computational as well as biophysical approaches based on nuclear magnetic resonance (NMR) fragment screening are powerful approaches, but suffer from specific constraints that limit their usage. Here, we demonstrate the applicability of high-throughput thermal scanning (HTTS) as a simple and generic biophysical fragment screening method to reproduce assessments from NMR-based screening...
May 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28537445/ultraviolet-induced-surface-grafting-of-octafluoropentyl-methacrylate-on-polyether-ether-ketone-for-inducing-antibiofilm-properties
#11
Parisa Amdjadi, Hanieh Nojehdehian, Farhood Najafi, Amir Ghasemi, Massoud Seifi, Erfan Dashtimoghadam, Farahnaz Fahimipour, Lobat Tayebi
Since octafluoropentyl methacrylate is an antifouling polymer, surface modification of polyether ether ketone with octafluoropentyl methacrylate is a practical approach to obtaining anti-biofilm biocompatible devices. In the current study, the surface treatment of polyether ether ketone by the use of ultraviolet irradiation, so as to graft (octafluoropentyl methacrylate) polymer chains, was initially implemented and then investigated. The Fourier-transform infrared and nuclear magnetic resonance spectra corroborated the appearance of new signals associated with the fluoroacrylate group...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28537389/silsesquioxane-terpyridine-nano-building-blocks-for-the-design-of-three-dimensional-polymeric-networks
#12
Esther Carbonell, Lucia A Bivona, Luca Fusaro, Carmela Aprile
Novel polyhedral oligomeric silsesquioxanes (POSS) decorated with eight terpyridine moieties were synthesized in a one-pot procedure via Heck coupling reaction with the aim of investigating the possible formation of three-dimensional extended supramolecular organizations. The monosubstituted analogue was also prepared and used as a model compound. Both POSS-based nanostructures were extensively characterized via (1)H, (13)C, and (29)Si nuclear magnetic resonance (NMR), ultraviolet-visible spectroscopies and combustion chemical analysis...
May 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28537016/sorption-mechanism-of-enrofloxacin-on-humic-acids-extracted-from-brazilian-soils
#13
Mónica J Martínez-Mejía, Isabela Sato, Susanne Rath
Veterinary antimicrobials are emerging environmental contaminants of concern. In this study, the sorption of enrofloxacin (ENR) onto humic acids (HAs) extracted from three Brazilian soils was evaluated. HAs were characterized by elemental analysis and solid (13)C nuclear magnetic resonance spectroscopy. The sorption of ENR onto HAs was at least 20-fold higher than onto the soils from which they were separated. Ionic and cation bridging are the primary interactions involved. The interactions driven by cation exchange are predominant on HAs, which appear to have abundant carboxylic groups and a relatively high proportion of H-bond donor moieties with carbohydrate-like structures...
May 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28535610/nitric-oxide-inhibition-and-procollagen-type-i-peptide-synthesis-of-a-phenolic-amide-identified-from-the-stem-of-lycium-chinense-miller
#14
Chan Saem Gil, Moon-Sik Chang, Seok Hyun Eom
The bioactivities of boxthron fruits, a source of oriental medicine, are known, while phytochemical studies of the boxthorn stem are rare. In this study, the stem extract of boxthorn (Lycium chinense Miller) and its sub-fractions were evaluated for their effects on nitric oxide (NO) inhibition and procollagen type I peptide (PIP) synthesis. A phenolic amide isolated from the stem extract was also assayed for these effects. The compound, N-trans-feruloyltyramine, was identified by (1)H, (13)C, and 2D-nuclear magnetic resonance analysis...
May 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28535606/isolation-purification-and-characterization-of-five-active-diketopiperazine-derivatives-from-endophytic-streptomyces-suk-25-with-antimicrobial-and-cytotoxic-activities
#15
Muhanna M Alshaibani, Juriyati Jalil, Nik M Sidik, Siti Junaidah Ahmad, Nurkhalida Kamal, Ruangelie Edrada-Ebel, Noraziah M Zin
On our search for new sources of bioactive secondary metabolites from Streptomyces sp., the ethyl acetate extracts from the endophytic Streptomyces SUK 25 afforded five active diketopiperazines compounds. The aim of this study was to characterize the bioactive compounds isolated from endophytic Streptomyces SUK 25 and evaluate its bioactivity against multiple drug resistance (MDR) bacteria such as Enterococcus raffinosus, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterobacter spp...
May 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28535423/chromatographic-separation-and-detection-methods-of-aloe-arborescens-miller-constituents-a-systematic-review
#16
REVIEW
Jilan A Nazeam, Haidy A Gad, Hala M El-Hefnawy, Abdel-Naser B Singab
Aloe arborescens Miller (Family Asphodelaceae) is a member of genus Aloe, which is used in traditional medicine to cure various diseases. The extracts of the plant have been reported to possess anticancer, immunomodulator, antidiabetic, anti-inflammatory and antioxidant activities. The phytochemical investigations have revealed diverse chemical constituents, including phenolics [anthraquinones, anthrones, pyrones, chromones and coumarins], polysaccharides [arborans [(1-4) linked glucomannans, polysaccharide (A, B and C): (A: a linear (1-6)-O-α-glucan, B: a branching (1-2)-O-l-arabinose with (1-2)-O-d-galactose linkages and C: (1-4)-O-β-mannan with 18% acetyl group)]], glycoproteins and carboxypeptidase enzyme...
April 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28535421/differentiation-of-crataegus-spp-guided-by-nuclear-magnetic-resonance-spectrometry-with-chemometric-analyses
#17
Jensen A Lund, Paula N Brown, Paul R Shipley
For compliance with US Current Good Manufacturing Practice regulations for dietary supplements, manufacturers must provide identity of source plant material. Despite the popularity of hawthorn as a dietary supplement, relatively little is known about the comparative phytochemistry of different hawthorn species, and in particular North American hawthorns. The combination of NMR spectrometry with chemometric analyses offers an innovative approach to differentiating hawthorn species and exploring the phytochemistry...
May 20, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28535056/solid-state-nmr-structure-based-inhibitor-design-to-achieve-selective-inhibition-of-the-parallel-in-register-%C3%AE-sheet-versus-antiparallel-iowa-mutant-%C3%AE-amyloid-fibrils
#18
Qinghui Cheng, Wei Qiang
Solid-state nuclear magnetic resonance (ssNMR) spectroscopy has been widely applied to characterize the high-resolution structures of β-amyloid (Aβ) fibrils. While these structures provide crucial molecular insights on the deposition of amyloid plaques in Alzheimer's diseases (AD), ssNMR structures have been rarely used so far as basis for designing inhibitors. It remains a challenge because the ssNMR-based Aβ fibrils structures were usually obtained with sparsely-isotope-labeled peptides with limited experimental constraints, where the structural models, especially the side-chain coordinates showed restricted precision...
May 23, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28535035/fabrication-of-anti-biofouling-plasma-filtration-membrane-by-electrospinning-process-using-photo-crosslinkable-zwitterionic-phospholipid-polymers
#19
Jiae Seo, Ji-Hun Seo
The goal of this study is to fabricate a stable plasma filtration membrane with anti-biofouling properties via an electrospinning process. To this end, a random-type copolymer consisting of zwitterionic phosphorylcholine (PC) groups and ultraviolet (UV)-crosslinkable phenyl azide groups was synthesized. The zwitterionic PC group provides anti-biofouling properties, and the phenyl azide group enables the stable maintenance of the fibrous nanostructure of hydrophilic zwitterion polymers in aqueous medium via a simple UV curing process...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28535000/staging-performance-of-whole-body-dwi-pet-ct-and-pet-mri-in-invasive-ductal-carcinoma-of-the-breast
#20
Onofrio Antonio Catalano, Dania Daye, Alberto Signore, Carlo Iannace, Mark Vangel, Angelo Luongo, Marco Catalano, Mazzeo Filomena, Luigi Mansi, Andrea Soricelli, Marco Salvatore, Niccolo Fuin, Ciprian Catana, Umar Mahmood, Bruce Robert Rosen
The aim of the present study was to evaluate the performance of whole-body diffusion-weighted imaging (WB-DWI), whole-body positron emission tomography with computed tomography (WB-PET/CT), and whole-body positron emission tomography with magnetic resonance imaging (WB-PET/MRI) in staging patients with untreated invasive ductal carcinoma of the breast. Fifty-one women with newly diagnosed invasive ductal carcinoma of the breast underwent WB-DWI, WB-PET/CT and WB-PET/MRI before treatment. A radiologist and a nuclear medicine physician reviewed in consensus the images from the three modalities and searched for occurrence, number and location of metastases...
May 19, 2017: International Journal of Oncology
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