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Sarcopenia

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https://www.readbyqxmd.com/read/29234981/sarcopenia-after-induction-therapy-in-childhood-acute-lymphoblastic-leukemia-its-clinical-significance
#1
Daisuke Suzuki, Ryoji Kobayashi, Hirozumi Sano, Daiki Hori, Kunihiko Kobayashi
Muscle weakness is one of the most serious problems during chemotherapy for childhood hematological malignancies. It may be caused by long-term hospitalization, unfavorable physical conditions, and restricted activities. Although the concept of sarcopenia is becoming widely recognized, especially in geriatric medicine, there have been few reports about sarcopenia in pediatric patients with hematological malignancies. A total of 47 consecutive first-onset acute lymphoblastic leukemia (ALL) patients who underwent induction therapy between January 2011 and September 2016 were investigated...
December 12, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29234200/nutrition-and-muscle-in-cirrhosis
#2
REVIEW
Anil C Anand
As the cirrhosis progresses, development of complication like ascites, hepatic encephalopathy, variceal bleeding, kidney dysfunction, and hepatocellular carcinoma signify increasing risk of short term mortality. Malnutrition and muscle wasting (sarcopenia) is yet other complications that negatively impact survival, quality of life, and response to stressors, such as infection and surgery in patients with cirrhosis. Conventionally, these are not routinely looked for, because nutritional assessment can be a difficult especially if there is associated fluid retention and/or obesity...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234165/short-physical-performance-battery-for-cardiovascular-disease-inpatients-implications-for-critical-factors-and-sarcopenia
#3
Tomohiro Yasuda, Toshiaki Nakajima, Tatsuya Sawaguchi, Naohiro Nozawa, Tomoe Arakawa, Reiko Takahashi, Yuta Mizushima, Satoshi Katayanagi, Kazuhisa Matsumoto, Shigeru Toyoda, Teruo Inoue
We examined the relationship between Short Physical Performance Battery (SPPB) and clinical and laboratory factors and the effect of sarcopenia and sarcopenic obesity (SO) on clinical and laboratory factors for cardiovascular disease (CVD) inpatients. CVD male (n = 318) and female (n = 172) inpatients were recruited. A stepwise multiple-regression analysis was performed to predict total SPPB scores and assess clinical and laboratory factors (physical characteristics, functional and morphological assessments, etc...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233101/learning-from-older-peoples-reasons-for-participating-in-demanding-intensive-epidemiological-studies-a-qualitative-study
#4
Alicja M Baczynska, Sarah C Shaw, Harnish P Patel, Avan A Sayer, Helen C Roberts
BACKGROUND: Recruitment rates of older people in epidemiological studies, although relatively higher than in clinical trials, have declined in recent years. This study aimed to explore motivating factors and concerns among older participants in an intensive epidemiological study (Hertfordshire Sarcopenia Study - HSS) and identify those that could aid future recruitment to epidemiological studies and clinical trials. METHODS: Participants of the HSS fasted overnight and travelled several hours each way to the research facility at an English hospital for extensive diet/lifestyle questionnaires and investigations to assess muscle including blood tests and a muscle biopsy...
December 12, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29232264/fish-oil-derived-n-3-polyunsaturated-fatty-acids-for-the-prevention-and-treatment-of-sarcopenia
#5
Stuart R Gray, Bettina Mittendorfer
PURPOSE OF REVIEW: Muscle mass and function decline progressively starting in middle age, which can result in sarcopenia and affect people's mobility and independence later in life. Exercise training and increased protein intake are typically recommended to counteract the age-associated decline in muscle mass and function. However, few people comply with exercise recommendations and the effectiveness of high-protein intake to halt the decline in muscle mass and function has not been proven...
December 9, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29230694/anthropometric-changes-in-patients-with-pancreatic-cancer-undergoing-preoperative-therapy-and-pancreatoduodenectomy
#6
Jordan M Cloyd, Graciela M Nogueras-González, Laura R Prakash, Maria Q B Petzel, Nathan H Parker, An T Ngo-Huang, David Fogelman, Jason W Denbo, Naveen Garg, Michael P Kim, Jeffrey E Lee, Ching-Wei D Tzeng, Jason B Fleming, Matthew H G Katz
BACKGROUND: The changes in body composition that occur in response to therapy for localized pancreatic ductal adenocarcinoma (PDAC) and during the early survivorship period, as well as their clinical significance, are poorly understood. METHODS: One hundred twenty-seven consecutive patients with PDAC who received preoperative therapy followed by pancreatoduodenectomy (PD) at a single institution between 2009 and 2012 were longitudinally evaluated. Changes in skeletal muscle (SKM), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) were measured on serial computed tomography images obtained upon presentation, prior to pancreatectomy, and approximately 3 and 12 months after surgery...
December 11, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29229123/sarcopenia-is-a-risk-factor-for-complications-and-an-independent-predictor-of-hospital-length-of-stay-in-trauma-patients
#7
James DeAndrade, Mark Pedersen, Luis Garcia, Peter Nau
BACKGROUND: Sarcopenia is an independent risk factor for adverse outcomes in critically ill patients. The impact of sarcopenia on morbidity and length of stay in a trauma population has not been completely defined. This project evaluated the influence of sarcopenia on patients admitted to the trauma service. MATERIALS AND METHODS: A retrospective review of 778 patients presenting as a trauma alert at a single institution from 2012-2014 was completed. Records were abstracted for comorbidities and hospital complications...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228514/gait-speed-predicts-post-operative-medical-complications-in-elderly-gastric-cancer-patients-undergoing-gastrectomy
#8
Arvine Chandoo, Chu-Huai Chi, Weiping Ji, Yingpeng Huang, Xiao-Dong Chen, Wei-Teng Zhang, Rui-Sen Wu, Xian Shen
BACKGROUND: Gait speed is a clinical outcome that can measure the physical performance of elderly gastric patients. The purpose of this study was to determine the importance of gait speed in predicting post-operative morbidities in elderly patients undergoing curative gastrectomy. METHODS: We conducted a prospective study of 357 elderly patients (≥65 years old) undergoing curative gastrectomy. Preoperative gait speed was measured in a 6-m well-lit and unobstructed hallway...
December 11, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29224976/body-composition-and-clinical-symptoms-in-patients-with-hip-or-knee-osteoarthritis-results-from-the-khoala-cohort
#9
Clémence Jeanmaire, Bernard Mazières, Evelyne Verrouil, Lorraine Bernard, Francis Guillemin, Anne-Christine Rat
OBJECTIVE: To analyze the associations between body composition, notably low lean mass, and clinical symptoms [pain, physical function, quality of life (QoL)] in patients with symptomatic hip and/or knee OA. METHODS: Cross-sectional study using data from the 3-year follow-up visit of the Knee and Hip OsteoArthritis Long-term assessment (KHOALA) cohort. Skeletal muscle and fat mass were measured by dual X-ray absorptiometry (DXA). Fat mass index (FMI) was defined as total fat mass/height2...
October 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29224700/preventing-weakness-and-stiffness-a-top-priority-for-health-and-social-care
#10
REVIEW
Muir Gray, Kenny Butler
With growing evidence that sarcopenia, disability and frailty can be prevented with physical activity, people living with pain, stiffness and weakness due to a musculoskeletal condition should be offered physical activity as a preventive strategy. By changing beliefs and attitudes towards ageing and raising the value and importance of physical activity, disability can be avoided or delayed and the costly burden of social care lessened. The effects of ageing and the effects of muscle strength loss are often confused...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29224698/sarcopenia
#11
REVIEW
Nicholas Fuggle, Sarah Shaw, Elaine Dennison, Cyrus Cooper
Sarcopenia is a condition that is characterized by loss of muscle mass, muscle strength and muscle functional impairment with ageing. The definition of sarcopenia has been through various permutations; however, an enormous recent breakthrough is the inclusion of the condition in the ICD-10 classification of diseases. This chapter covers the background issues regarding definition before describing the epidemiology of the disease according to human and environmental factors. It then provides a practical guide for the assessment of sarcopenia in a clinical setting and finishes with advice on present treatment and the exciting frontiers of future therapies...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29224095/sex-differences-in-muscle-wasting
#12
Lindsey J Anderson, Haiming Liu, Jose M Garcia
With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasome activity, and suppressed protein synthesis and myocyte regeneration. Decreased food intake and physical activity also indirectly contribute to muscle wasting. Sex hormones also play important roles in maintaining skeletal muscle homeostasis. Testosterone is a potent anabolic factor promoting muscle protein synthesis and muscular regeneration...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29222895/sarcopenia-and-cachexia-evaluation-in-different-healthcare-settings-a-questionnaire-survey-of-health-professionals
#13
Saori Nakahara, Hidetaka Wakabayashi, Keisuke Maeda, Shinta Nishioka, Yoji Kokura
BACKGROUND AND OBJECTIVES: The rates of sarcopenia and cachexia evaluations by different occupational groups at different settings are unclear. The objectives are to evaluate and compare the relative use of sarcopenia and cachexia evaluations among dietitians and associated healthcare professionals in a diverse range of settings. METHODS AND STUDY DESIGN: Participants were 4,621 members from the Japanese Association of Rehabilitation Nutrition. Settings included acute general wards, convalescent rehabilitation wards, long-term care wards, homecare service, and other settings...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29221886/a-model-including-sarcopenia-surpasses-the-meld-score-in-predicting-waiting-list-mortality-in-cirrhotic-liver-transplant-candidates
#14
Jeroen Laurens Ad van Vugt, Louise Johanna Maria Alferink, Stefan Buettner, Marcia Patricia Gaspersz, Daphne Bot, Sarwa Darwish Murad, Shirin Feshtali, Peter Martinus Adranius van Ooijen, Wojciech Grzegorz Polak, Robert Jan Porte, Bart van Hoek, Aad Pieter van den Berg, Herold Johnny Metselaar, Jan Nicolaas Maria IJzermans
BACKGROUND AND AIMS: Frail patients with low MELD scores may be underprioritised. Low skeletal muscle mass (i.e. sarcopenia) has been identified as risk factor for waiting list mortality and a recent study proposed to incorporate sarcopenia in the MELD score (i.e. MELD-Sarcopenia score). We aimed to investigate the association between sarcopenia and waiting list mortality, and to validate the MELD-Sarcopenia score (i.e. MELD+10.35∗Sarcopenia). METHODS: We identified consecutive patients with cirrhosis listed for liver transplantation in the Eurotransplant registry between 2007-2014 and measured skeletal muscle mass on computed tomography (CT)...
December 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29217429/association-of-platelet-count-with-sarcopenic-obesity-in-postmenopausal-women-a-nationwide-population-based-study
#15
Woo-Jin Park, Dong-Hyuk Jung, Ji-Won Lee, Jae-Yong Shim, Yu-Jin Kwon
OBJECTIVES: The aim of this study was to examine the relationship between platelet count and sarcopenic obesity in postmenopausal women. METHOD: This cross-sectional study was conducted using nationally representative data. A total of 2810 postmenopausal women who participated in the 2008-2011 Korea National Health and Nutritional Examination Survey were included in this study. Sarcopenic obesity was defined by a sarcopenia criterion and an obesity criterion. Platelet counts were divided into quartiles as follows: Q, 150-222; Q2, 223-257; Q3, 258-294, and Q4, 295-450 (103/μl)...
December 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29216311/amelioration-of-sexual-behavior-and-motor-activity-deficits-in-a-castrated-rodent-model-with-a-selective-androgen-receptor-modulator-sarm-2f
#16
Megumi Morimoto, Yuichiro Amano, Masahiro Oka, Ayako Harada, Hisashi Fujita, Yukiko Hikichi, Ryuichi Tozawa, Masuo Yamaoka, Takahito Hara
Sarcopenia and cachexia present characteristic features of a decrease in skeletal muscle mass and strength, anorexia, and lack of motivation. Treatments for these diseases have not yet been established, although selective androgen receptor modulators (SARMs) are considered as therapeutic targets. We previously reported that a novel SARM compound, SARM-2f, exhibits anabolic effect on muscles, with less stimulatory effect on prostate weight compared with testosterone, in rat Hershberger assays and cancer cachexia models...
2017: PloS One
https://www.readbyqxmd.com/read/29215200/mir-424-5p-reduces-ribosomal-rna-and-protein-synthesis-in-muscle-wasting
#17
Martin Connolly, Richard Paul, Roser Farre-Garros, Samantha A Natanek, Susannah Bloch, Jen Lee, Jose P Lorenzo, Harnish Patel, Cyrus Cooper, Avan A Sayer, Stephen J Wort, Mark Griffiths, Michael I Polkey, Paul R Kemp
BACKGROUND: A loss of muscle mass occurs as a consequence of a range of chronic and acute diseases as well as in older age. This wasting results from an imbalance of protein synthesis and degradation with a reduction in synthesis and resistance to anabolic stimulation often reported features. Ribosomes are required for protein synthesis, so changes in the control of ribosome synthesis are potential contributors to muscle wasting. MicroRNAs (miRNAs) are known regulators of muscle phenotype and have been shown to modulate components of the protein synthetic pathway...
December 7, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29214748/alterations-in-the-in-vitro-and-in-vivo-regulation-of-muscle-regeneration-in-healthy-ageing-and-the-influence-of-sarcopenia
#18
Joanna Brzeszczyńska, Angelika Meyer, Robin McGregor, Alain Schilb, Simone Degen, Valentina Tadini, Neil Johns, Ramon Langen, Annemie Schols, David J Glass, Ronenn Roubenoff, James A Ross, Kenneth C H Fearon, Carolyn A Greig, Carsten Jacobi
BACKGROUND: Sarcopenia is defined as the age-related loss of skeletal muscle mass and function. While all humans lose muscle with age, 2-5% of elderly adults develop functional consequences (disabilities). The aim of this study was to investigate muscle myogenesis in healthy elderly adults, with or without sarcopenia, compared with middle-aged controls using both in vivo and in vitro approaches to explore potential biomarker or causative molecular pathways associated with sarcopenic versus non-sarcopenic skeletal muscle phenotypes during ageing...
December 6, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29214454/impact-of-sarcopenia-on-unplanned-readmission-and-survival-after-esophagectomy-in-patients-with-esophageal-cancer
#19
Daisuke Makiura, Rei Ono, Junichiro Inoue, Akimasa Fukuta, Miyuki Kashiwa, Yasushi Miura, Taro Oshikiri, Tetsu Nakamura, Yoshihiro Kakeji, Yoshitada Sakai
BACKGROUND: Although sarcopenia increases postoperative complications following esophagectomy, its effects on prognosis remain unclear. This study was performed to identify the effect of sarcopenia on 90-day unplanned readmission and overall survival (OS) after esophagectomy. METHODS: Ninety-eight patients with esophageal cancer who underwent esophagectomy were enrolled in this study. Unplanned readmission was defined as any emergent hospitalization within 90 days after discharge...
December 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29212996/-a-comparison-of-the-associations-of-dynapenia-and-sarcopenia-with-fear-of-falling-in-elderly-diabetic-patients
#20
Satoshi Ida, Kazuya Murata, Yuki Ishihara, Kanako Imataka, Ryutaro Kaneko, Ryoko Fujiwara, Hiroka Takahashi
AIM: To comparatively investigate whether dynapenia and sarcopenia, as defined by the Asian Working Group for Sarcopenia (AWGS), are associated with fear of falling in elderly patients with diabetes. METHODS: The subjects were outpatients with diabetes who were at least 65 years of age when they visited our hospital. Sarcopenia was evaluated based on the AWGS definition. The cutoff values for the appendicular skeletal mass index (multi-frequency bioelectrical impedance method), grip strength, and walking speed were, respectively, 7...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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