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Sarcopenia

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https://www.readbyqxmd.com/read/29452785/the-risks-of-sarcopenia-falls-and-fractures-in-patients-with-type-2-diabetes-mellitus
#1
REVIEW
C Sarodnik, S P G Bours, N C Schaper, J P van den Bergh, T A C M van Geel
Fracture risk in patients with type 2 diabetes mellitus (T2DM) is increased, and the mechanism is multifactorial. Recent research on T2DM-induced bone fragility shows that bone mineral density (BMD) is often normal or even slightly elevated. However, bone turnover may be decreased and bone material and microstructural properties are altered, especially when microvascular complications are present. Besides bone fragility, extra-skeletal factors leading to an increased propensity to experience falls may also contribute to the increased fracture risk in T2DM, such as peripheral neuropathy, retinopathy and diabetes medication (e...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29452783/oxidative-stress-is-increased-in-sarcopenia-and-associated-with-cardiovascular-disease-risk-in-sarcopenic-obesity
#2
Francesco Bellanti, Antonino D Romano, Aurelio Lo Buglio, Valeria Castriotta, Giuseppe Guglielmi, Antonio Greco, Gaetano Serviddio, Gianluigi Vendemiale
OBJECTIVES: To define whether circulating markers of oxidative stress correlate with sarcopenia in terms of glutathione balance and oxidative protein damage, and whether these biomarkers are associated with risk of cardiovascular disease (CVD). STUDY DESIGN: Population-based cross-sectional study. 115 out of 347 elderly subjects were classified as non-sarcopenic non-obese (NS-NO), sarcopenic non-obese (S-NO), non-sarcopenic obese (NS-O), and sarcopenic obese (S-O)...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29452288/repetitive-tlr-3-activation-in-the-lung-induces-skeletal-muscle-adaptations-and-cachexia
#3
Ted G Graber, Brandy L Rawls, Bing Tian, William J Durham, Camille R Brightwell, Allan R Brasier, Blake B Rasmussen, Christopher S Fry
Due to immunosenescence, older adults are particularly susceptible to lung-based viral infections, with increased severity of symptoms in those with underlying chronic lung disease. Repeated respiratory viral infections produce lung maladaptations, accelerating pulmonary dysfunction. Toll like 3 receptor (TLR3) is a membrane protein that senses exogenous double-stranded RNA to activate the innate immune response to a viral infection. Polyinosinic-polycytidylic acid [poly(I:C)] mimics double stranded RNA and has been shown to activate TLR3...
February 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29451848/mr-imaging-of-atraumatic-muscle-disorders
#4
Edward Smitaman, Dyan V Flores, Catalina Mejía Gómez, Mini N Pathria
Atraumatic disorders of skeletal muscles include congenital variants; inherited myopathies; acquired inflammatory, infectious, or ischemic disorders; neoplastic diseases; and conditions leading to muscle atrophy. These have overlapping appearances at magnetic resonance (MR) imaging and are challenging for the radiologist to differentiate. The authors organize muscle disorders into four MR imaging patterns: (a) abnormal anatomy with normal signal intensity, (b) edema/inflammation, (c) mass, and (d) atrophy, highlighting each of their key clinical and imaging findings...
February 16, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29451419/physical-exercise-nutrition-and-hormones-three-pillars-to-fight-sarcopenia
#5
Paolo Sgrò, Massimiliano Sansone, Andrea Sansone, Stefania Sabatini, Paolo Borrione, Francesco Romanelli, Luigi Di Luigi
BACKGROUND: Sarcopenia is a pathophysiological condition diffused in elderly people; it represents a social issue due to the longer life expectancy and the growing aging population. It affects negatively quality of life and it represents a risk factor for other pathologies, such as diabetes, cardiovascular disease, and obesity. No silver bullet exists to hinder sarcopenia, but it may be counteracted by physical exercise, nutrition, and a proper endocrine milieu. Indeed, we aim to analyze the scientific literature to give to clinician effective advices to counteract sarcopenia...
February 16, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29451179/sarcopenia-and-risk-of-nonalcoholic-fatty-liver-disease-a-meta-analysis
#6
REVIEW
Karn Wijarnpreecha, Panadeekarn Panjawatanan, Charat Thongprayoon, Veeravich Jaruvongvanich, Patompong Ungprasert
Background/Aim: The association between sarcopenia and nonalcoholic fatty liver disease (NAFLD) has been suggested by recent epidemiological studies, although the results have been inconsistent. This meta-analysis was conducted to summarize all available data and estimate the risk of NAFLD among patients with sarcopenia. Materials and Methods: A comprehensive literature review was conducted using MEDLINE and EMBASE databases through November 2016 to identify all studies that compared the risk of NAFLD among patients with sarcopenia versus those without sarcopenia...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29447254/loop-diuretics-are-associated-with-greater-risk-of-sarcopenia-in-patients-with-non-dialysis-dependent-chronic-kidney-disease
#7
Seiko Ishikawa, Shotaro Naito, Soichiro Iimori, Daiei Takahashi, Moko Zeniya, Hidehiko Sato, Naohiro Nomura, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Tatemitsu Rai
INTRODUCTION: Sarcopenia, the age-related loss of muscle mass and function, frequently accompanies chronic kidney disease. The aim of this study was to clarify the prevalence and the risk factors for sarcopenia among patients with non-dialysis-dependent chronic kidney disease (NDD-CKD), focusing on the use of drugs. METHODS: We conducted a cross-sectional analysis on a cohort of 260 patients with NDD-CKD in a university hospital, recruited between June 2016 and March 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29445830/bone-health-assessment-in-older-people-with-or-without-muscle-health-impairment
#8
M Locquet, C Beaudart, O Bruyère, J A Kanis, L Delandsheere, J-Y Reginster
This study investigated the relationship between muscle and bone status in elderly individuals. Our results suggested links between sarcopenia and osteoporosis; impairment in muscle status (i.e., muscle mass, muscle strength, and physical performance) is associated with deterioration in bone mass and texture subsequently leading to an increased risk of fracture. INTRODUCTION: Accumulating evidence has shown associations between sarcopenia and osteoporosis, but existing studies face inconsistencies in the clinical definition of both conditions...
February 14, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29440681/a-sarcopenia-screening-test-predicts-mortality-in-hospitalized-older-adults
#9
Tianjiao Tang, Linna Wu, Ling Yang, Jiaojiao Jiang, Qiukui Hao, Birong Dong, Ming Yang
The aim of this study is to investigate the validation of a sarcopenia screening test (Ishii's formula) for predicting long-term mortality among older adult inpatients. A prospective, observational study was conducted in acute geriatric wards at three hospitals in western China. Sarcopenia was estimated using Ishii's formula. Survival status was assessed at 12, 24, and 36 months after the baseline investigation. Cox proportional-hazard models were applied to calculate the hazard ratio for mortality associated with sarcopenia...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440390/high-dietary-fat-and-sucrose-results-in-an-extensive-and-time-dependent-deterioration-in-health-of-multiple-physiological-systems-in-mice
#10
James G Burchfield, Melkam A Kebede, Christopher C Meoli, Jacqueline Stöckli, P Tess Whitworth, Amanda L Wright, Nolan J Hoffman, Annabel Y Minard, Xiuquan Ma, James R Krycer, Marin E Nelson, Shi-Xiong Tan, Belinda Yau, Kristen C Thomas, Natalie K Y Wee, Ee-Cheng Khor, Ronaldo F Enriquez, Bryce Vissel, Trevor J Biden, Paul A Baldock, Kyle L Hoehn, James Cantley, Gregory J Cooney, David E James, Daniel J Fazakerley
Obesity is associated with metabolic dysfunction, including insulin resistance and hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and neurodegeneration. Typically, these pathologies are examined in discrete model systems and with limited temporal resolution, and whether these disorders co-occur is therefore unclear. To address this question, we examined multiple physiological systems in male C57BL/6J mice following prolonged exposure to a high-fat/high-sucrose diet (HFHSD)...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29440373/calcium-supplementation-in-osteoporosis-useful-or-harmful
#11
Iacopo Chiodini, Mark J Bolland
Osteoporosis and fragility fractures are important social and economic problems worldwide and are due to both the loss of bone mineral density and sarcopenia. Indeed, fragility fractures are associated with increased disability, morbidity and mortality. It is known that a normal calcium balance together with a normal vitamin D status is important for maintaining well-balanced bone metabolism and for many years calcium and vitamin D has been considered crucial in the prevention and treatment of osteoporosis...
February 12, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29438735/high-intensity-stretch-shortening-contraction-training-modifies-responsivity-of-skeletal-muscle-in-old-male-rats
#12
Erik P Rader, Marshall A Naimo, James Ensey, Brent A Baker
Utilization of high-intensity resistance training to counter age-related sarcopenia is currently debated because of the potential for maladaptation when training design is inappropriate. Training design is problematic because the influence of various loading variables (e.g. contraction mode, repetition number, and training frequency) is still not well characterized at old age. To address this in a precisely controlled manner, we developed a rodent model of high-intensity training consisting of maximally-activated stretch-shortening contractions (SSCs), contractions typical during resistance training...
February 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29436734/risk-of-malnutrition-evaluated-by-mini-nutritional-assessment-and-sarcopenia-in-noninstitutionalized-elderly-people
#13
Ilaria Liguori, Francesco Curcio, Gennaro Russo, Michele Cellurale, Luisa Aran, Giulia Bulli, David Della-Morte, Gaetano Gargiulo, Gianluca Testa, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
BACKGROUND: Malnutrition indices and muscle mass and strength in the elderly are poorly investigated. Moreover, malnutrition seems to be 1 of the more important factors in the cause of sarcopenia. The presence of sarcopenia and its relationship with malnutrition indices were studied in noninstitutionalized elderly people who underwent Comprehensive Geriatric Assessment (CGA). METHODS: A total of 473 elderly subjects (mean age, 80.9 ± 6.6 years) admitted to CGA were studied...
February 13, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29435297/a-low-psoas-muscle-volume-predicts-longer-hospitalization-and-cancer-recurrence-in-upper-urinary-tract-urothelial-carcinoma
#14
Sohgo Tsutsumi, Takashi Kawahara, Jun-Ichi Teranishi, Masahiro Yao, Hiroji Uemura
The aging population is becoming a primary global problem. The most important alteration that occurs in the body with age, is the loss of skeletal muscle. Previously, sarcopenia, which is associated with the loss of skeletal muscle, has been reported to be associated with the prognosis of cancer and complications. The present study investigated the importance of sarcopenia with regard to the prognosis or postoperative complications of upper urothelial cancer patients who underwent nephro-ureterectomy. A total of sixty patients (male, n=44; female, n=16) underwent nephro-ureterectomy for upper urothelial carcinoma...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29433749/sarcopenia-is-not-associated-with-morbidity-mortality-or-recurrence-after-esophagectomy-for-cancer
#15
Ralph W Aye Md
No abstract text is available yet for this article.
January 31, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29433514/loss-of-skeletal-muscle-mass-during-neoadjuvant-treatments-correlates-with-worse-prognosis-in-esophageal-cancer-a-retrospective-cohort-study
#16
Tommi Järvinen, Ilkka Ilonen, Juha Kauppi, Jarmo Salo, Jari Räsänen
BACKGROUND: Nutritional deficits, cachexia, and sarcopenia are extremely common in esophageal cancer. The aim of this article was to assess the effect of loss of skeletal muscle mass during neoadjuvant treatment on the prognosis of esophageal cancer patients. METHODS: Esophageal cancer patients (N = 115) undergoing neoadjuvant therapy and surgery between 2010 and 2014 were identified from our surgery database and retrospectively analyzed. Computed tomography imaging of the total cross-sectional muscle tissue measured at the third lumbar level defined the skeletal muscle index, which defined sarcopenia (SMI < 52...
February 12, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29431561/effects-of-resistance-training-of-peripheral-muscles-versus-respiratory-muscles-in-institutionalized-older-adults-with-sarcopenia-a-randomized-controlled-trial
#17
Maria À Cebrià I Iranzo, Mercè Balasch I Bernat, María Á Tortosa-Chuliá, Sebastià Balasch-Parisi
This study compares the effects of two resistance training programs in peripheral and respiratory musculature on muscle mass and strength and physical performance, and identify the appropriate muscle mass parameter for assessing the intervention effects. Thirty-seven institutionalized older Spanish adults with sarcopenia were analyzed: Control Group (n=17), Respiratory Muscle Training Group (n=9) and Peripheral Muscle Training Group (n=11). Pre and post-intervention, participants were assessed for Appendicular Skeletal Mass (ASM/height2; ASM/weight; ASM/BMI), isometric knee-extension, arm-flexion and handgrip strength, Inspiratory and Expiratory Maximal Pressures (MIP and MEP), and gait speed...
February 12, 2018: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/29430248/decreased-muscle-strength-and-quality-in-diabetes-related-dementia
#18
Akito Tsugawa, Yusuke Ogawa, Naoto Takenoshita, Yoshitsugu Kaneko, Hirokuni Hatanaka, Eriko Jaime, Raita Fukasawa, Haruo Hanyu
Background/Aims: Diabetes-related dementia (DrD), a dementia subgroup associated with specific diabetes mellitus (DM)-related metabolic abnormalities, is clinically and pathophysiologically different from Alzheimer disease (AD) and vascular dementia. We determined whether skeletal muscle strength, quality, and mass decrease in individuals with DrD. Methods: We evaluated grip and knee extension strength, muscle mass, and gait speed in 106 patients with probable AD and without type 2 DM (AD[-DM] group), 74 patients with probable AD and with DM (AD[+DM] group), and 36 patients with DrD (DrD group)...
September 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29426485/untangling-the-overlap-between-frailty-and-low-lean-mass-data-from-toulouse-frailty-day-hospital
#19
Bertrand Fougère, Sandrine Sourdet, Matthieu Lilamand, Maturin Tabue-Teguod, Bernard Teysseyre, Charlotte Dupuy, Bruno Vellas, Yves Rolland, Fati Nourhashemi, Gabor Abellan van Kan
BACKGROUND: The decline in lean mass, observed in older people, has been frequently associated with frailty. This assumption has scarcely been assessed. This study explored the association between current proposed definitions of low lean mass and the Fried phenotype of frailty. METHODS: Cross-sectional study. Participants admitted to the Toulouse frailty day hospital, with an assessment of body composition, 70 years or older were included consecutively in the study...
March 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29421778/prevalence-of-sarcopenia-and-dynapenia-and-their-determinants-in-iranian-peritoneal-dialysis-patients
#20
Atefeh As'habi, Iraj Najafi, Hadi Tabibi, Mehdi Hedayati
INTRODUCTION: Uremic sarcopenia and dynapenia are prevalent in chronic kidney disease patients, including dialysis patients. The present study was designed to determine the prevalence of sarcopenia and dynapenia and their determinants in peritoneal dialysis (PD) patients in Tehran, Iran. MATERIALS AND METHODS: All eligible PD patients at the peritoneal dialysis centers of Tehran were included in this cross-sectional study. Skeletal muscle mass and muscle strength were assessed using bioelectrical impedance analysis and hand grip strength, respectively...
January 2018: Iranian Journal of Kidney Diseases
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