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Sarcopenia

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https://www.readbyqxmd.com/read/29931626/do-sarcopenia-and-or-osteoporosis-increase-the-risk-of-frailty-a-4-year-observation-of-the-second-and-third-road-study-surveys
#1
N Yoshimura, S Muraki, H Oka, T Iidaka, R Kodama, C Horii, H Kawaguchi, K Nakamura, T Akune, S Tanaka
In this 4-year follow-up study including 1083 subjects (≥ 60 years), the prevalence of frailty was estimated to be 5.6%; osteoporosis was found to be significantly associated with frailty. Moreover, the presence of both osteoporosis and sarcopenia increased the risk of frailty compared to the presence of osteoporosis or sarcopenia alone. INTRODUCTION: This study aims to examine the contribution of sarcopenia and osteoporosis to the occurrence of frailty using 4-year follow-up information of a population-based cohort study...
June 21, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29928932/is-increased-neutrophil-lymphocyte-ratio-remarking-the-inflammation-in-sarcopenia
#2
Zeynel Abidin Öztürk, Seval Kul, İbrahim Halil Türkbeyler, Zeynel Abidin Sayıner, Azer Abiyev
OBJECTIVES: Increasing data suggests that chronic inflammation has an essential role on development of muscle dysfunction and progression of sarcopenia in aging population. The aim of the present study was to compare Neutrophil Lymphocyte Ratio (NLR) levels in sarcopenic and non-sarcopenic individuals and to present the correlation between NLR and other inflammatory markers. METHODS: A total of 105 subjects with sarcopenia (male/female: 54/51, mean age 72.8 ± 7...
June 18, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29927763/nutrition-dietary-intake-and-eating-behavior-after-liver-transplantation
#3
Lucilene Rezende Anastácio, Samanta Catherine Ferreira
PURPOSE OF REVIEW: Nutritional status of patients after liver transplantation is affected by dietary intake and this, in turn, is affected by eating behavior. The present review will highlight recent studies on these topics after liver transplantation. RECENT FINDINGS: Malnutrition drops significantly after liver transplantation. Recovery of weight lost during liver disease occurs within 1 year. Liver transplantation recipients gain weight up to the second or third year, often becoming overweight and obese...
June 20, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29926516/serum-albumin-inflammation-and-nutrition-in-end-stage-renal-disease-c-reactive-protein-is-needed-for-optimal-assessment
#4
EDITORIAL
Hideyuki Mukai, Hilda Villafuerte, Abdul Rashid Qureshi, Bengt Lindholm, Peter Stenvinkel
Low serum albumin (S-Alb) is a frequent feature of end-stage renal disease (ESRD) that independently predicts mortality. Serum albumin has mainly been considered a biomarker of visceral protein and immunocompetence status, fundamental to nutritional assessment. However, low S-albumin level is associated with persistent systemic inflammation and many bodies of evidence show that S-Alb has a limited role as a marker of nutritional status. We reported that a low S-Alb concentration was an independent risk factor for poor outcome in ESRD only in the presence of systemic inflammation...
June 21, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29926227/sarcopenia-in-a-mice-model-of-chronic-liver-disease-role-of-the-ubiquitin-proteasome-system-and-oxidative-stress
#5
Fabián Campos, Johanna Abrigo, Francisco Aguirre, Bruno Garcés, Marco Arrese, Saul Karpen, Daniel Cabrera, Marcelo E Andía, Felipe Simon, Claudio Cabello-Verrugio
Sarcopenia is the loss of muscle mass and strength produced by aging or secondary to chronic diseases such as chronic liver disease (CLD). Although not all types of sarcopenia involve the same features, the most common are decreased fiber diameter and myosin heavy chain (MHC) levels, increased activity of ubiquitin-proteasome system (UPS) and reactive oxygen species (ROS). In this study, we aim to characterize the development of sarcopenia secondary to CLD induced by the hepatotoxin 5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)...
June 20, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29925868/high-throughput-screening-of-mitochondrial-bioenergetics-in-human-differentiated-myotubes-identifies-novel-enhancers-of-muscle-performance-in-aged-mice
#6
Nadine Biesemann, Janina S Ried, Danping Ding-Pfennigdorff, Axel Dietrich, Christine Rudolph, Steffen Hahn, Wolfgang Hennerici, Christian Asbrand, Thomas Leeuw, Carsten Strübing
Mitochondrial dysfunction is increasingly recognized as a contributor to age-related muscle loss and functional impairment. Therefore, we developed a high throughput screening strategy that enabled the identification of compounds boosting mitochondrial energy production in a human skeletal muscle cell model. Screening of 7949 pure natural products revealed 22 molecules that significantly increased oxygen consumption and ATP levels in myotubes. One of the most potent compounds was the flavanone hesperetin. Hesperetin (10 µM) increased intracellular ATP by 33% and mitochondrial spare capacity by 25%...
June 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29925301/mobility-exercise-nutrition-and-healthy-ageing-to-avoid-sarcopenia
#7
Maisy Provan, Tony Mander
No abstract text is available yet for this article.
June 2018: Post Reproductive Health
https://www.readbyqxmd.com/read/29922911/relationship-between-low-handgrip-strength-and-quality-of-life-in-korean-men-and-women
#8
Seo Young Kang, Jisun Lim, Hye Soon Park
PURPOSE: Handgrip strength is strongly related to muscle power in the extremities and is an important index for diagnosing sarcopenia. We evaluated the relationship between handgrip strength and quality of life (QoL) in Korean men and women. METHODS: We analyzed 4620 participants (2070 men and 2550 women) using data from the Korea National Health and Nutrition Examination Survey VI-3 (2015). Low handgrip strength was defined as the lower quartile of handgrip strength in the study population...
June 19, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29922049/sarcopenic-obesity-and-cognitive-performance
#9
Magdalena I Tolea, Stephanie Chrisphonte, James E Galvin
Background: Sarcopenia and obesity both negatively impact health including cognitive function. Their coexistence, however, can pose an even higher threat likely surpassing their individual effects. We assessed the relationship of sarcopenic obesity with performance on global- and subdomain-specific tests of cognition. Patients and methods: The study was a cross-sectional analysis of data from a series of community-based aging and memory studies. The sample consisted of a total of 353 participants with an average age of 69 years with a clinic visit and valid cognitive (eg, Montreal Cognitive Assessment, animal naming), functional (eg, grip strength, chair stands), and body composition (eg, muscle mass, body mass index, percent body fat) measurements...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29922046/usual-gait-speed-is-associated-with-frailty-status-institutionalization-and-mortality-in-community-dwelling-rural-older-adults-a-longitudinal-analysis-of-the-aging-study-of-pyeongchang-rural-area
#10
Hee-Won Jung, Il-Young Jang, Chang Ki Lee, Sang Soo Yu, Jae Kyoon Hwang, Chawoong Jeon, Young Soo Lee, Eunju Lee
Purpose: We aimed to describe the age- and sex-specific distributions of gait speed and to evaluate associations with longitudinal outcomes in Korean rural community-dwelling older adults. Patients and methods: A total of 1,348 people (mean age: 76 years, 55% women) in the population-based, prospective cohort of Aging Study of Pyeongchang Rural Area (ASPRA) between October 2014 and June 2017. All participants underwent a comprehensive geriatric assessment, including 4-m usual gait speed, and were followed annually...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29921962/differences-in-the-prevalence-of-sarcopenia-in-peritoneal-dialysis-patients-using-hand-grip-strength-and-appendicular-lean-mass-depends-upon-guideline-definitions
#11
Asmat Abro, Lara-Anne Delicata, Surachet Vongsanim, Andrew Davenport
BACKGROUND: Peritoneal dialysis (PD) patients with sarcopenia have increased risk of mortality. There is consensus that sarcopenia should combine assessments of muscle function and mass. We wished to determine the effect of using different operational definitions in PD patients. METHODS: Hand grip strength (HGS) and segmental bioimpedance derived appendicular lean mass (ALM) were measured and the prevalence of sarcopenia determined using the Foundation for the National Institutes of Health Sarcopenia Project (FNIH), European Working Group on Sarcopenia Older Persons (EWGSOP), and Asian Working Group on Sarcopenia (AWGS) definitions...
June 19, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29921462/validation-of-the-sarcopenia-index-to-assess-muscle-mass-in-the-critically-ill-a-novel-application-of-kidney-function-markers
#12
Erin F Barreto, Janelle O Poyant, Hongchuan H Coville, Ross A Dierkhising, Cassie C Kennedy, Ognjen Gajic, Erin M Nystrom, Naoki Takahashi, Michael R Moynagh, Kianoush B Kashani
BACKGROUND & AIMS: Adverse outcomes for hospitalized patients with sarcopenia are well documented, and identification of patients at risk remains challenging. The sarcopenia index (SI), previously defined as (serum creatinine/serum cystatin C) × 100, could be an inexpensive, readily accessible, objective tool to predict muscle mass and risk for adverse clinical outcomes. The aim of this study was to assess the validity of the SI as a predictor of muscle mass. METHODS: Retrospective study of critically ill adults admitted to Mayo Clinic from 2012 to 2015 with suspected sepsis and an available creatinine and serum cystatin C...
June 8, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29920701/sarcopenia-is-associated-with-the-risk-of-significant-liver-fibrosis-in-metabolically-unhealthy-subjects-with-chronic-hepatitis-b
#13
E Han, Y-H Lee, B K Kim, J Y Park, D Y Kim, S H Ahn, B-W Lee, E S Kang, B-S Cha, K-H Han, S U Kim
BACKGROUND: Sarcopenia is significantly associated with the degree of liver fibrosis. This study investigated the influence of sarcopenia on liver fibrosis in individuals with chronic hepatitis B. METHODS: Data from the Korean National Health and Nutrition Examination Surveys 2008-2011 were analysed. The sarcopenia index (total appendicular skeletal muscle mass [kg]/body mass index [kg/m2 ]) was calculated using dual-energy X-ray absorptiometry. Sarcopenia was defined as the lowest quintile sarcopenia index value (cut-offs: 0...
June 19, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29916089/association-between-skeletal-muscle-mass-and-cardiorespiratory-fitness-in-community-dwelling-elderly-men
#14
Seung-Hyun Boo, Min Cheol Joo, Jeong Mi Lee, Seung Chan Kim, Young Mi Yu, Min-Su Kim
BACKGROUND: Sarcopenia reduces physical ability and cardiorespiratory fitness (CRF), leading to poor quality of life. AIM: The aim of this study was to investigate the relationship between skeletal muscle mass and CRF in elderly men. METHODS: We assessed 102 community-dwelling men over 60 years old. Appendicular skeletal muscle mass (ASM) was determined using bioelectrical impedance analysis, and the skeletal muscle mass index (SMI) was calculated as ASM divided by the square of height...
June 18, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29914840/altered-body-composition-sarcopenia-frailty-and-their-clinico-biological-correlates-in-parkinson-s-disease
#15
Ai Huey Tan, Yin Cheng Hew, Shen-Yang Lim, Norlisah Mohd Ramli, Shahrul Bahyah Kamaruzzaman, Maw Pin Tan, Mathis Grossmann, Ban Hong Ang, Jiun Yan Tan, Mohamad Addin Azhan A Manap, Tun Khong Tay, Siang Lyn Tan, Ru Peng New, Farhana Fadzli, Eng Jui Yee, Foong Ming Moy, Sanjiv Mahadeva, Anthony E Lang
INTRODUCTION: Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention in PD. We studied body composition, sarcopenia, frailty, and their clinico-biological correlates in PD. METHODS: 93 patients and 78 spousal/sibling controls underwent comprehensive assessment of diet, clinical status, muscle strength/performance, frailty, body composition (using dual-energy X-ray absorptiometry), and serum levels of neurogastrointestinal hormones and inflammatory markers...
June 13, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29912922/impact-of-pre-sarcopenia-in-sorafenib-treatment-for-advanced-hepatocellular-carcinoma
#16
Hitomi Takada, Masayuki Kurosaki, Hiroyuki Nakanishi, Yuka Takahashi, Jun Itakura, Kaoru Tsuchiya, Yutaka Yasui, Nobuharu Tamaki, Kenta Takaura, Yasuyuki Komiyama, Mayu Higuchi, Youhei Kubota, Wann Wang, Mao Okada, Nobuyuki Enomoto, Namiki Izumi
BACKGROUND: The present study aimed to investigate the impact of pre-sarcopenia on the prognosis of patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. METHODS: We enrolled 214 patients (71 ± 10 years old; 166 men and 48 women; 90% Child-Pugh grade A and 10% Child-Pugh grade B) treated with sorafenib in our hospital from July 2009 to August 2016. The muscle volume was measured from CT images just before sorafenib administration using software (SliceOmatic)...
2018: PloS One
https://www.readbyqxmd.com/read/29912727/ultrasound-imaging-for-sarcopenia-spasticity-and-painful-muscle-syndromes
#17
Levent Özçakar, Ayşe Merve Ata, Bayram Kaymak, Murat Kara, Dinesh Kumbhare
PURPOSE OF REVIEW: On the basis of its various advantages and the relevant awareness of physicians, ultrasound imaging has overwhelmingly taken its place in the scientific arena. This is true both from the side of daily clinical applications and also from the side of research. Yet, ultrasound provides real-time (diagnostic) imaging and (interventional) guidance for a wide spectrum of muscle disorders. In this regard, this review aims to discuss the potential/actual utility of ultrasound imaging in particular muscle disorders, that is, sarcopenia, spasticity and fibromyalgia/myofascial pain syndrome...
June 15, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29910736/thyroid-hormones-play-role-in-sarcopenia-and-myopathies
#18
Flavia F Bloise, Thamires S Oliveira, Aline Cordeiro, Tania M Ortiga-Carvalho
Skeletal muscle maintains posture and enables movement by converting chemical energy into mechanical energy, further contributing to basal energy metabolism. Thyroid hormones (thyroxine, or T4, and triiodothyronine, or T3) participate in contractile function, metabolic processes, myogenesis and regeneration of skeletal muscle. T3 classically modulates gene expression after binding to thyroid hormone nuclear receptors. Thyroid hormone effects depend on nuclear receptor occupancy, which is directly related to intracellular T3 levels...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29910068/leisure-time-physical-activity-at-moderate-and-high-intensity-is-associated-with-parameters-of-body-composition-muscle-strength-and-sarcopenia-in-aged-adults-with-obesity-and-metabolic-syndrome-from-the-predimed-plus-study
#19
Nuria Rosique-Esteban, Nancy Babio, Andrés Díaz-López, Dora Romaguera, J Alfredo Martínez, Vicente Martin Sanchez, Helmut Schröder, Ramón Estruch, Josep Vidal, Pilar Buil-Cosiales, Jadwiga Konieczna, Itziar Abete, Jordi Salas-Salvadó
AIMS: We aimed to examine the associations of leisure-time physical activity (PA) and sedentary behavior (SB) with the prevalence of sarcopenia, body composition and muscle strength among older adults having overweight/obesity and metabolic syndrome, from the PREDIMED-Plus trial. METHODS: Cross-sectional baseline analysis including 1539 men and women (65 ± 5 y). Sarcopenia was defined as low muscle mass (according to FNIH cut-offs) plus low muscle strength (lowest sex-specific tertile for 30-s chair-stand test)...
June 6, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29909813/reduced-plasma-concentration-of-branched-chain-amino-acids-in-sarcopenic-older-subjects-a-cross-sectional-study
#20
Inger Ottestad, Stine M Ulven, Linn K L Øyri, Kristin S Sandvei, Gyrd O Gjevestad, Asta Bye, Navida A Sheikh, Anne S Biong, Lene F Andersen, Kirsten B Holven
Branched-chain amino acids (BCAA) are essential amino acids that are necessary for muscle mass maintenance. Little is known about the plasma concentrations of BCAA and the protein intake in relation to sarcopenia. We aimed to compare the non-fasting plasma concentrations of the BCAA and the dietary protein intake between sarcopenic and non-sarcopenic older adults. Norwegian older home-dwelling adults (≥70 years) were invited to a cross-sectional study with no other exclusion criteria than age. Sarcopenic subjects were defined by the diagnostic criteria by the European Working Group on Sarcopenia in Older People...
June 18, 2018: British Journal of Nutrition
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