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M C Gouveia, J P Vella, F R Cafeo, F L Affonso Fonseca, M R Bacci
OBJECTIVE: Irisin is a muscle-secreted protein released into the circulation by cleavage of fibronectin type III domain containing protein 5(FNDC5). Since its discovery in 2012, it has been the subject of many researches due to its physiological role. It is believed that understanding irisin's function may be the key to comprehend many diseases and their development. The aim of this study is to perform a systematic review in order to establish whether there is an association of irisin's levels with obesity, diabetes mellitus, non-alcoholic steatohepatitis, chronic kidney disease and cancer in terms of prognosis...
October 2016: European Review for Medical and Pharmacological Sciences
Roland J Jr Thorpe, Eleanor Simonsick, Alan Zonderman, Michelle K Evans
BACKGROUND: Poor grip strength is an indicator of frailty and a precursor to functional limitations. Although poor grip strength is more prevalent in older disabled African American women, little is known about the association between race and poverty-related disparities and grip strength in middle-aged men and women. METHODS: We examined the cross-sectional relationship between race, socioeconomic status as assessed by household income, and hand grip strength in men and women in the Healthy Aging in Neighborhoods of Diversity across the Life Span study...
October 20, 2016: Ethnicity & Disease
Ryan Hamilton, Michael Walsh, Rashmi Singh, Karl Rodriguez, Xiaoli Gao, Md Mizanur Rahman, Asish Chaudhuri, Arunabh Bhattacharya
Aging is associated with a decline in peripheral nerve function of both motor and sensory nerves. The decline in function of peripheral sensorimotor nerves with aging has been linked to sarcopenia, the age-related decline in muscle mass and function that significantly compromises the quality of life in older humans. In this study, we report a significant increase in oxidized fatty acids and insoluble protein carbonyls in sciatic nerves of aged C57BL/6 male mice (28-30mo) that exhibit a profound decline in motor nerve function and degenerative changes in both axon and myelin structure, compared to young mice (6-8mo)...
November 15, 2016: Journal of the Neurological Sciences
Sophie Joanisse, Joshua P Nederveen, Tim Snijders, Bryon R McKay, Gianni Parise
Sarcopenia is the age-related loss of skeletal muscle mass and strength. Ultimately, sarcopenia results in the loss of independence, which imposes a large financial burden on healthcare systems worldwide. A critical facet of sarcopenia is the diminished ability for aged muscle to regenerate, repair and remodel. Over the years, research has focused on elucidating underlying mechanisms of sarcopenia and the impaired ability of muscle to respond to stimuli with aging. Muscle-specific stem cells, termed satellite cells (SC), play an important role in maintaining muscle health throughout the lifespan...
October 20, 2016: Gerontology
Maria Helena Gusmao-Sena, Karine Curvello-Silva, Jairza Maria Barreto-Medeiros, Carla Hilário Da-Cunha-Daltro
INTRODUCTION: The main changes in the body composition refer to the increase of adipose tissue and/or the decrease of muscular mass, and these changes have effect in many clinical outcomes. Sarcopenic obesity (SO) consists of the presence of excessive adipose tissue and deficit of muscular mass simultaneously. People with SO may have synergistic effect due to obesity and sarcopenia, with increases cardiovascular risk more than obesity itself. OBJECTIVE: To describe the findings in the literature about the association between SO and risk factors and/or cardiometabolic disease (CMD) or cardiovascular disease (CVD)...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Alan Pestronk, Richard Keeling, Rati Choksi
OBJECTIVE: We studied mitochondrial impairment as a factor in the pathologic equivalent of sarcopenia, muscle fiber atrophy associated with increased age. METHODS: Mitochondrial oxidative enzyme activities and coenzyme Q10 levels were measured in frozen human proximal limb muscles with combined age and atrophy, age alone, atrophy alone, denervation, immune myopathies, and mitochondrial disorders with ophthalmoplegia. RESULTS: Sarcopenia (age and atrophy) had reduced mean activities of mitochondrial Complexes I, II, and II+III, with severe reduction of Complex I activity in 54% of patients...
October 19, 2016: Muscle & Nerve
Andrew Kien Han Wee
BACKGROUND: Old age and diabetes mellitus are risk factors for vitamin deficiencies, weakness and falls. Deficiencies of vitamin D, and possibly vitamin B12 and folate (which are associated with hyperhomocysteinaemia), contribute to sarcopenia. Determination of the physical effects of vitamin deficiencies in specific groups of people can help to guide public health policy with regard to vitamin supplementation. METHODS: A pilot cross-sectional study was conducted to determine the association of levels of vitamin D, vitamin B12, folate and homocysteine with muscle strength, gait and fall history in 56 patients >65 years old with diabetes mellitus in primary care in Singapore...
October 18, 2016: Nutrition Journal
Koki Takane, Yu Hasegawa, Lin Bowen, Takashi Yokoo, Shokei Kim-Mitsuyama
OBJECTIVE: Increasing evidences suggest that patients with Alzheimer's disease (AD) show not only cognitive impairment but also physical disorder including cardiac dysfunction and sarcopenia. In this study, we investigated whether central angiotensin II, inducer of oxidative stress, led to the organ dysfunction in a mouse model of AD. DESIGN AND METHOD: 5XFAD which is an animal model of AD and C57BL/6 (WT) were each assigned to 1) normal saline and 2) angiotensin II (20 mg/kg/h) groups...
September 2016: Journal of Hypertension
Yuki Imaizumi, Kazuo Eguchi, Toshiki Kaihara, Kumiko Urano, Rieko Shinagawa, Minoru Araki, Koji Inoue, Koichiro Hokao, Yuka Tsujita, Takuya Furusawa, Ryuichiro Kaku, Kazuomi Kario
OBJECTIVE: We tested the hypothesis that sarcopenia, an age-related loss of skeletal muscle mass and function, is associated with arterial stiffness in patients with diabetes (DM). DESIGN AND METHOD: We studied 65 hypertensives in the Real BP study, an observational study of home BP telemonitoring system. As parameters of sarcopenia, we used locomotive syndrome scale, circumference of the wrist, lower leg, and thigh (10 cm above the patella), grip strength, and 6 minute-walk test...
September 2016: Journal of Hypertension
Tomonori Sato, Yoshiaki Ito, Takashi Nagasawa
Sarcopenia is a condition of the loss of muscle mass that is associated with aging and that increases the risk for bedridden state, thereby warranting studies of interventions that attenuate sarcopenia. Here the effects of 2-month dietary L-lysine (Lys) supplementation (1.5-3.0 %) on myofibrillar protein degradation and major proteolytic systems were investigated in senescence-accelerated mouse prone 8 (SAMP8). At 36 weeks of age, skeletal muscle and lean body mass was reduced in SAMP8 when compared with control senescence-accelerated mouse resistant 1 (SAMR1)...
October 17, 2016: Biogerontology
Dong-Won Lee, Eun-Young Choi
BACKGROUND: A decrease in bone mineral density (BMD) is a systemic consequence of chronic obstructive pulmonary disease (COPD). Past reports have rarely examined any correlation between sarcopenia and BMD. We investigated the relationship cross-sectionally between the presence of sarcopenia and BMD reduction in COPD patients. METHODS: COPD patients aged 50 or older with qualifying spirometry and dual-energy X-ray absorptiometry data were from participants in the Korean National Health and Nutrition Examination Surveys IV and V (2008-2011)...
2016: PloS One
Olivier Bruyère, Etienne Cavalier, Fanny Buckinx, Jean-Yves Reginster
PURPOSE OF REVIEW: This article reviews recently published evidence regarding the role of vitamin D in the physiopathology of physical frailty in elderly populations and its role in the management of this geriatric condition. RECENT FINDINGS: Some recent studies have found a low level of 25-hydroxyvitamin D, considered the best marker of vitamin D status, in frail individuals. All prospective studies consistently report that low vitamin D status is associated with an increased risk of becoming frail...
October 1, 2016: Current Opinion in Clinical Nutrition and Metabolic Care
Yoon Suk Jung, Nam Hee Kim, Seungho Ryu, Jung Ho Park, Dong Il Park, Chong Il Sohn
GOALS: We aimed to ascertain whether low relative muscle mass is associated with colorectal neoplasm (CRN) risk. BACKGROUND: CRN and sarcopenia have common pathophysiological mechanisms such as insulin resistance, chronic inflammation, and physical inactivity. However, the direct relationship between the 2 diseases has not been investigated. STUDY: A cross-sectional study was performed on 81,885 examinees who underwent colonoscopy as part of a health check-up...
October 4, 2016: Journal of Clinical Gastroenterology
Rhett L Peterson, Kate C Parkinson, Jeffrey B Mason
Previously, transplantation of ovaries from young cycling mice into old postreproductive-age mice increased life span. We anticipated that the same factors that increased life span could also influence health span. Female CBA/J mice received new (60 d) ovaries at 12 and 17 months of age and were evaluated at 16 and 25 months of age, respectively. There were no significant differences in body weight among any age or treatment group. The percentage of fat mass was significantly increased at 13 and 16 months of age but was reduced by ovarian transplantation in 16-month-old mice...
2016: Journal of Transplantation
Ryuta Shintakuya, Kenichiro Uemura, Yoshiaki Murakami, Naru Kondo, Naoya Nakagawa, Kazuhide Urabe, Keisuke Okano, Kazuo Awai, Toru Higaki, Taijiro Sueda
BACKGROUND/OBJECTIVES: The loss of skeletal muscle mass (sarcopenia) is associated with the poor prognosis of pancreatic cancer. It has been reported pancreatic exocrine insufficiency (PEI) is associated with serum nutritional markers in chronic pancreatitis. However, there has been no report about the relationship between sarcopenia and PEI. The aim of this study is to determine whether body composition, including skeletal muscle (SM), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), intramuscular adipose tissue content (IMAC), and serum nutritional markers are associated with pancreatic exocrine function in patients with pancreatic disease...
October 11, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Irene Fleur Kramer, Lex B Verdijk, Henrike M Hamer, Sjors Verlaan, Yvette C Luiking, Imre W K Kouw, Joan M Senden, Janneau van Kranenburg, Annemarie P Gijsen, Jörgen Bierau, Martijn Poeze, Luc J C van Loon
BACKGROUND: Studying the muscle protein synthetic response to food intake in elderly is important, as it aids the development of interventions to combat sarcopenia. Although sarcopenic elderly are the target group for many of these nutritional interventions, no studies have assessed basal or post-prandial muscle protein synthesis rates in this population. OBJECTIVE: To assess the basal and post-prandial muscle protein synthesis rates between healthy and sarcopenic older men...
September 29, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Gianni Biolo, Rado Pišot, Sara Mazzucco, Filippo Giorgio Di Girolamo, Roberta Situlin, Stefano Lazzer, Bruno Grassi, Carlo Reggiani, Angelina Passaro, Joern Rittweger, Mladen Gasparini, Boštjan Šimunič, Marco Narici
BACKGROUND & AIMS: Aging and experimental bed rest are associated with muscle atrophy and resistance to post-prandial stimulation of protein synthesis or anabolic resistance (AR). We have used in young and older adult volunteers, during short-term bed rest, a quick and non-invasive method, based on a single oral bolus of the stable isotope L[ring-(2)H5]phenylalanine (D5Phe), to determine post-prandial AR, defined as ratio between irreversible hydroxylation and incorporation into body protein of ingested phenylalanine...
September 30, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
David Scott, Markus Seibel, Robert Cumming, Vasi Naganathan, Fiona Blyth, David G Le Couteur, David J Handelsman, Louise M Waite, Vasant Hirani
Body composition and muscle function have important implications for falls and fractures in older adults. We aimed to investigate longitudinal associations between sarcopenic obesity and its components with bone mineral density (BMD), and incident falls and fractures, in Australian community-dwelling older men. 1,486 men aged ≥70 years from the Concord Health and Ageing in Men Project (CHAMP) study were assessed at baseline (2005-2007), 2 year follow-up (2007-2009; N = 1,238), and 5 year follow-up (2010-2013; N = 861)...
October 13, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Matheus Amarante DO Nascimento, Aline M Gerage, Renata S Januário, Fábio L Pina, Luís A Gobbo, Jerry L Mayhew, Edilson S Cyrino
BACKGROUND: Evidence suggests that the aging process tends to lead to sarcopenia and osteoporosis which reduce the quality of life in older women. Resistance training (RT) is widely supported as a means of delaying or offsetting the decline in muscle strength and loss of bone mineral content in older women. The purpose of this investigation was to analyze the effects of a 12-wk RT program (3 times a week) with dietary intake maintenance on muscle strength and body composition of healthy, sedentary older women...
October 13, 2016: Journal of Sports Medicine and Physical Fitness
Nicholas G Wysham, Ryan D Nipp, Thomas W LeBlanc, Steven P Wolf, Magnus P Ekstrom, David C Currow
Thoracic sarcopenia can feasibly be measured from routine CT scans but does not correlate to patient-centred outcomes
April 2016: ERJ Open Research
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