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Soft tissue calcification

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https://www.readbyqxmd.com/read/28441370/conventional-modalities-and-novel-emerging-imaging-techniques-for-musculoskeletal-tumors
#1
Meera Raghavan
BACKGROUND: Imaging of musculoskeletal tumors requires a multimodality approach and includes radiography, computed tomography (CT), and magnetic resonance imaging (MRI). METHODS: Topics related to primary bone and soft-tissue tumors are reviewed. The fundamental imaging principles are discussed as well as the applications of emerging imaging modalities. RESULTS: MRI is the preferred technique for the evaluation of musculoskeletal tumors, whereas other imaging modalities play a complementary role...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28440087/cervical-dural-calcification-and-cervical-myelopathy-in-x-linked-hypophosphataemic-rickets-a-case-report-and-review-of-the-literature
#2
Ali A Najefi, Daniel B Beder, Shiraz A Sabah, Kia Rezajooi
X-linked hypophosphataemic rickets (XLHR) is a genetic disorder resulting from a genetic mutation in the PHEX gene. This may cause ossification of soft tissue structures risking spinal cord compression. We present the first known case of cervical dural calcification secondary to XLHR to cause myelopathic symptoms due to cord compression.
April 25, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28430540/demystifying-orbital-emergencies-a-pictorial-review
#3
Viet D Nguyen, Achint K Singh, Wilson B Altmeyer, Bundhit Tantiwongkosi
Imaging of the orbit plays an important role in the workup of orbital emergencies. Orbital imaging is particularly useful in the emergency department, where clinical history and physical examination may be limited or delayed until the exclusion or treatment of more life-threatening conditions. Cross-sectional orbital imaging with multidetector computed tomography (CT) and magnetic resonance (MR) imaging is commonly performed in addition to ultrasonography. In an emergent setting, CT is the preferred modality when evaluating for intraorbital foreign bodies, fractures, or calcifications within a mass lesion...
April 21, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28429550/parathyroid-hormone-targets-in-chronic-kidney-disease-and-managing-severe-hyperparathyroidism
#4
Carmel M Hawley, Stephen G Holt
Appropriate targets for parathyroid hormone (PTH) in patients with chronic kidney disease (CKD) stages 3-5D are controversial, as are the means by which these targets might be achieved. Secondary hyperparathyroidism is linked to symptoms like bone pain and itch, in addition to less clinically overt issues like bone fragility as well as vascular and soft tissue calcification which may lead to adverse hard endpoints, particularly fracture and death. Recognized therapies for managing a rising PTH include vitamin D analogues, with or without calcimimetic (where available), in addition to management of serum mineral concentrations with diet, binders and dialysis...
March 2017: Nephrology
https://www.readbyqxmd.com/read/28416300/pyrophosphate-supplementation-prevents-chronic-and-acute-calcification-in-abcc6-deficient-mice
#5
Viola Pomozi, Christopher Brampton, Koen van de Wetering, Janna Zoll, Bianca Calio, Kevin Pham, Jesse B Owens, Joel Marh, Stefan Moisyadi, András Váradi, Ludovic Martin, Carolin Bauer, Jeanette Erdmann, Zouhair Aherrahrou, Olivier Le Saux
Soft tissue calcification occurs in several common acquired pathologies, such as diabetes and hypercholesterolemia, or can result from genetic disorders. ABCC6, a transmembrane transporter primarily expressed in liver and kidneys, initiates a molecular pathway inhibiting ectopic calcification. ABCC6 facilitates the cellular efflux of ATP, which is rapidly converted into pyrophosphate (PPi), a major calcification inhibitor. Heritable mutations in ABCC6 underlie the incurable calcification disorder pseudoxanthoma elasticum and some cases of generalized arterial calcification of infancy...
April 14, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28403237/evidence-of-neurofibromatosis-type-1-in-a-multi-morbid-inca-child-mummy-a-paleoradiological-investigation-using-computed-tomography
#6
Stephanie Panzer, Holger Wittig, Stephanie Zesch, Wilfried Rosendahl, Sandra Blache, Magdalena Müller-Gerbl, Gerhard Hotz
OBJECTIVE: In this study, an Inca bundle was examined using computed tomography (CT). The primary aim was to determine the preservation status of bony and soft tissues, the sex, the age at the time of death, possible indicators for disease or even the cause of death, as well as the kind of mummification. A secondary aim was to obtain a brief overview of the wrapping in order to gain additional information on the cultural background. MATERIALS AND METHODS: The bundle belongs to the Museum of Cultures in Basel, Switzerland, and was bought in Munich, Germany, in 1921...
2017: PloS One
https://www.readbyqxmd.com/read/28352499/metastatic-prostate-adenocarcinoma-to-the-brain-case-reports-and-literature-review
#7
Alexander Lam, Peter Y C Gan
Cerebral metastasis secondary to prostatic adenocarcinoma is rare and it is usually a late complication in patients with widespread distant metastases. Here, we report two unusual cases of such a rare condition. Our first case presented with a large frontal contrast-enhancing lesion-associated calcification and a large tumor cyst as shown on computed tomography and magnetic resonance imaging. This is the fifth reported case of prostatic metastasis manifesting as a cystic intraparenchymal tumor in the literature...
January 2017: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/28340679/insights-into-pathomechanisms-and-treatment-development-in-heritable-ectopic-mineralization-disorders-summary-of-the-pxe-international-biennial%C3%A2-research-symposium-2016
#8
Jouni Uitto, Qiaoli Li, Koen van de Wetering, András Váradi, Sharon F Terry
Pseudoxanthoma elasticum is a prototype of heritable ectopic mineralization disorders, with phenotypic overlap with generalized arterial calcification of infancy and arterial calcification due to CD73 deficiency. Recent observations have suggested that the reduced inorganic pyrophosphate/phosphate ratio is the cause of soft connective tissue mineralization in these disorders. PXE International, a patient advocacy organization, supports research in part by sponsoring biennial research symposia on these disorders; the latest meeting was held in September 2016 at Thomas Jefferson University, Philadelphia...
April 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28303297/acute-calcific-tendinopathy-of-the-popliteus-tendon-a-rare-case-diagnosed-using-a-multimodality-imaging-approach-and-treated-conservatively
#9
Cédric Doucet, Akshat Gotra, Santhosh Mauvva Venkatesh Reddy, Mathieu Boily
Acute calcific tendinopathy of the popliteus tendon is a rare medical entity associated with significant patient discomfort. We present the case of a previously healthy 48-year-old female who presented to the emergency department with acute onset of left knee pain. Initial radiographs revealed calcifications within the posterolateral compartment of the knee. Ultrasound imaging demonstrated a swollen and hypoechoic popliteus tendon with an increased color Doppler signal at the periphery of the tendon as well as calcification in the tendon and adjacent soft tissues...
March 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28301584/diagnostic-accuracy-and-added-value-of-dual-energy-subtraction-radiography-compared-to-standard-conventional-radiography-using-computed-tomography-as-standard-of-reference
#10
Katharina Martini, Marco Baessler, Stephan Baumueller, Thomas Frauenfelder
PURPOSE: To retrospectively evaluate diagnostic performance of dual-energy subtraction radiography (DESR) for interpretation of chest radiographs compared to conventional radiography (CR) using computed tomography (CT) as standard of reference. MATERIAL AND METHODS: A total of 199 patients (75 female, median age 67) were included in this institutional review board (IRB)-approved clinical trial. All patients were scanned in posteroanterior and lateral direction with dual-shot DE-technique...
2017: PloS One
https://www.readbyqxmd.com/read/28290186/phosphorus-and-other-aspects-of-ckd-mbd-in-the-conservative-management-of-chronic-kidney-disease
#11
Anuja Shah
As the prevalence of chronic kidney disease (CKD) increases and the population ages, there is an imperative to offer cost effective and patient specific therapeutic options for the management of advanced CKD. In cases where there is a desire to avoid or delay renal replacement therapy, conservative options need to be defined and strategies for delaying the need for renal replacement therapy should be offered. CKD-mineral bone disorders (MBD) refers to the constellation of disturbances in abnormal bone and soft tissue calcification along with abnormalities, in phosphorus, calcium, parathyroid hormone, vitamin D, and FGF-23...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28289512/giant-abdominal-osteosarcoma-causing-intestinal-obstruction-treated-with-resection-and-adjuvant-chemotherapy
#12
Alexandros Diamantis, Grigorios Christodoulidis, Dionysia Vasdeki, Foteini Karasavvidou, Evangelos Margonis, Konstantinos Tepetes
Extraskeletal osteosarcoma (ESOS) is an uncommon tumor that accounts for 1% of all soft tissue sarcomas and 4% of all osteosarcomas. Its presentation may be atypical, while pain has been described as the most common symptom. Radiological findings include a large mass in the soft-tissues with massive calcifications, but no attachment to the adjacent bone or periosteum. We present the case of a 73-year-old gentle man who presented with a palpable, tender abdominal mass and symptoms of bowel obstruction. Computer tomography images revealed a large space-occupying heterogeneous, hyper dense soft tissue mass involving the small intestine...
February 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28248868/epithelioid-hemangioendothelioma-of-right-innominate-vein-mimics-a-teratoma-a-case-report
#13
Qi Wan, Jiaxuan Zhou, Yudong Yu, Qingyu Sun, Yingying Bao, Qiang Lei, Qiao Zou, Yingshi Deng, Xinchun Li
RATIONAL: Epithelioid hemangioendothelioma (EHE) is a rare neoplasm commonly known to arise from the soft tissue, lung, and liver. EHE arising from right innominate vein (RIV) has scarcely been reported in English literature. PATIENT CONCERNS: Herein, we present a rare case of EHE of RIV in a 51-year-old woman with right-lower chest pain for 4 days. Computed tomography of the chest revealed a spherical mass with calcification and fatty foci located in the anterior mediastinum, thus a presumptive diagnosis of teratoma was made...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28237727/tolerance-to-1-25-dihydroxyvitamin-d3-glycosides-from-solanum-glaucophyllum-by-the-growing-pig
#14
P Schlegel, D Guggisberg, A Gutzwiller
Solanum glaucophyllum leaves contain high levels of glycosidically bound 1,25 dihydroxyvitamin D3, the most important vitamin D metabolite. The tolerance to this source was evaluated during six weeks with fifty weaned pigs fed increasing levels (0, 2.5, 5, 10 and 20μg 1,25(OH)2D3/kg diet). The diet contained, per kg, 9.7g Ca, 3.5g digestible P and 2000IU cholecalciferol. Ten additional pigs were fed a diet containing 1000IU cholecalciferol/kg, without 1,25(OH)2D3. Weekly plasma and final kidney, bone and urinary mineral contents, bone density and breaking strength served as indicators for possible adverse effects of the supplement...
February 16, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28228905/calciphylaxis-on-bone-scan-correlation-between-molecular-and-cross-sectional-findings
#15
Malak Itani, Manuela Matesan, Sanaz Behnia, Saeed Elojeimy
Calciphylaxis is a rare devastating medical condition commonly associated with end-stage renal disease and characterized by extensive microvascular calcifications. We describe a case of calciphylaxis presenting on Tc-99m MDP bone scan imaging with asymmetric radiotracer uptake within the lower extremities corresponding to extensive soft tissue calcifications on Computed tomography. Familiarity with the classic clinical presentation and imaging features of this rare entity may help its early identification and treatment...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28217238/fetus-in-fetu-case-report-and-brief-review-of-literature-on-embryologic-origin-clinical-presentation-imaging-and-differential-diagnosis
#16
Suhas Aithal Sitharama, Bibekanand Jindal, Mrudula Kumari Vuriti, Bikash Kumar Naredi, Sriram Krishnamurthy, Deepak Barathi Subramania
BACKGROUND: Fetus in fetu (FIF) is a rare entity in which a malformed diamniotic monochorionic parasitic fetal twin develops inside a normal co-twin's body, most commonly in the abdominal cavity. FIF is differentiated from the teratoma by the presence of vertebral column often with an appropriate arrangement of other organs or limbs around it. CASE REPORT: A two-and-a-half-year-old girl presented with a painless abdominal swelling in the right hypochondrium. On imaging, a heterogenous soft tissue mass with internal calcific densities was noted in the retroperitoneum...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28193220/a-rare-case-of-multiple-phosphaturic-mesenchymal-tumors-along-a-tendon-sheath-inducing-osteomalacia
#17
Ryuta Arai, Tomohiro Onodera, Mohamad Alaa Terkawi, Tomoko Mitsuhashi, Eiji Kondo, Norimasa Iwasaki
BACKGROUND: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, reduction of 1,25-dihydroxyl vitamin D, and bone calcification disorders. Tumors associated with TIO are typically phosphaturic mesenchymal tumors that are bone and soft tissue origin and often present as a solitary tumor. The high production of fibroblast growth factor 23 (FGF23) by the tumor is believed to be the causative factor responsible for the impaired renal tubular phosphate reabsorption, hypophosphatemia and osteomalacia...
February 13, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28164050/extraskeletal-mesenchymal-chondrosarcoma-of-shoulder-an-extremely-rare-case
#18
Salman Ghaffari, Ali Farsavian, Seyed Mohamad Mehdi Daneshpoor, Masoud Shayesteh Azar
INTRODUCTION: Extraskeletal chondrosarcoma (EMC) is a rare, aggressive neoplasm which has been seen in the soft tissue area. This soft tissue sarcoma is classified to myxoid and mesenchymal based on histologic criteria. The mesenchymal subtype has a poor prognosis. In approximately 50% of patient with EMC, we could observe soft tissue lesion and stippled calcification in the conventional radiography. CASE REPORT: In the current paper, we introduced a 47-year-old Iranian male patient having painless, mobile, nontender, and firm mass in left shoulder...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28139094/benign-features-of-infection-related-tumor-like-lesions-of-the-lung-a-retrospective-imaging-review-study
#19
Chun-Chao Huang, Sho-Ting Hung, Wei-Chin Chang, Chin-Yin Sheu
INTRODUCTION: Differentiation of benign and malignant pulmonary tumor-like lesions is challenging but increasingly important. We evaluate the most common imaging features in benign lesions based on the frequency of their appearance and compare with corresponding frequencies in malignant tumors from literature. METHODS: Retrospective imaging review study in one center between 1 January 2012 and 30 June 2014. We reviewed the data from 2466 pathological examinations of lung specimens collected from the hospital...
January 31, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28076010/foreign-bodies-on-lateral-neck-radiographs-in-adults-imaging-findings-and-common-pitfalls
#20
Alba Castán Senar, Laura E Dinu, José M Artigas, Raquel Larrosa, Ylenia Navarro, Elena Angulo
Foreign-body (FB) ingestion is less common in adults than in children, but still occurs. Diagnostic management of patients with suspected FB ingestion in emergency departments depends on FB type and location, both of which are related to the patient profile. In adults, fish and chicken bones are the most common FB types, and the oropharynx and cricopharyngeal muscle are the most common locations. Once accidentally swallowed, an FB may become lodged in the oropharynx, and in such cases indirect or fiberoptic laryngoscopy is the first clinical management option...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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