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Soft tissue calcification

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https://www.readbyqxmd.com/read/29786640/vitamin-d-in-vascular-calcification-a-double-edged-sword
#1
REVIEW
Jeffrey Wang, Jimmy J Zhou, Graham R Robertson, Vincent W Lee
Vascular calcification (VC) as a manifestation of perturbed mineral balance, is associated with aging, diabetes and kidney dysfunction, as well as poorer patient outcomes. Due to the current limited understanding of the pathophysiology of vascular calcification, the development of effective preventative and therapeutic strategies remains a significant clinical challenge. Recent evidence suggests that traditional risk factors for cardiovascular disease, such as left ventricular hypertrophy and dyslipidaemia, fail to account for clinical observations of vascular calcification...
May 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29753400/updates-on-the-mechanisms-and-the-care-of-cardiovascular-calcification-in-chronic-kidney-disease
#2
REVIEW
Lucie Hénaut, Jean-Marc Chillon, Saïd Kamel, Ziad A Massy
In chronic kidney disease (CKD), the progressive decrease in renal function leads to disturbances of mineral metabolism that generally cause secondary hyperparathyroidism. The increase in serum parathyroid hormone is associated with reduced serum calcium and calcitriol levels and/or increased serum fibroblast growth factor-23 and phosphate levels. The resulting CKD-associated disorder of mineral and bone metabolism is associated with various other metabolic dysregulations such as acidosis, malnutrition, inflammation, and accumulation of uremic toxins...
May 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29742599/the-detection-of-uterine-leiomyoma-fibroid-calcifications-on-18f-naf-pet-ct
#3
Abdullah Al-Zaghal, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi
Uterine leiomyomas (fibroids) are the most common type of uterine neoplasms in premenopausal women. Leiomyomas are estrogen dependent and tend to atrophy and shrink in size after menopause. Dystrophic calcification, cystic changes, and necrosis are among the changes that indicate uterine fibroid involution. We are presenting a calcified uterine leiomyoma in a 61-year-old woman as incidentally detected on F-NaF PET/CT scanning. Many previous publications have reported the accumulation of F-NaF in soft tissue calcifications; these findings further set new directions in the evaluation of the metabolic activity of macrocalcification and microcalcification using molecular imaging probes...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29742152/characterization-of-snf472-pharmacokinetics-and-efficacy-in-uremic-and-non-uremic-rats-models-of-cardiovascular-calcification
#4
Miguel D Ferrer, Markus Ketteler, Fernando Tur, Eva Tur, Bernat Isern, Carolina Salcedo, Pieter H Joubert, Geert J Behets, Ellen Neven, Patrick C D'Haese, Joan Perelló
End-stage renal disease is strongly associated with progressive cardiovascular calcification (CVC) and there is currently no therapy targeted to treat CVC. SNF472 is an experimental formulation under development for treatment of soft tissue calcification. We have investigated the pharmacokinetics of SNF472 administration in rats and its inhibitory effects on CVC. SNF472 was studied in three rat models: (1) prevention of vitamin D3-induced CVC with an intravenous SNF472 bolus of 1 mg/kg SNF472, (2) inhibition of progression of vitamin D3-induced CVC with a subcutaneous SNF472 bolus of 10 or 60 mg/kg SNF472, starting after calcification induction, (3) CVC in adenine-induced uremic rats treated with 50 mg/kg SNF472 via i...
2018: PloS One
https://www.readbyqxmd.com/read/29731908/calcific-myonecrosis-mimicking-soft-tissue-sarcoma-a-case-report
#5
Yuichiro Ukon, Takaaki Tanaka, Shigenori Nagata, Hiroki Hagizawa, Yoshinori Imura, Hironari Tamiya, Kazuya Oshima, Norifumi Naka, Yasuaki Aoki, Shigeyuki Kuratsu
Calcific myonecrosis is a rare soft tissue condition. The first case was reported in 1960, however, the precise pathophysiology of calcific myonecrosis remains unclear. The disease was thought to arise from compartment syndrome within a confined space resulting in necrosis and fibrosis, subsequent repeated intralesional hemorrhage, mass enlargement and calcification. Several previous reports have described calcific myonecrosis, which include the formation of calcific myonecrosis after a prolonged period of post trauma...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29730464/prevalence-of-calcifications-in-soft-tissues-visible-on-a-dental-pantomogram-a-retrospective-analysis
#6
Ana Ribeiro, Ross Keat, Sehrish Khalid, Senathirajah Ariyaratnam, Meeral Makwana, Maria do Pranto, Rui Albuquerque, Luis Monteiro
OBJECTIVES: To determine the frequency and spectrum of soft tissues calcifications identified on Dental Pantomograms (DPT) at a University Dental Clinic in the northern region of Portugal and to compare the data obtained with those published in the literature. METHODS: We conducted a 3-year descriptive analysis (2012-2014) of DPT calcifications within soft tissues at the University Clinic (CESPU), in Oporto, Portugal. Information on gender, age, location of the lesions and the radiographic diagnosis were analysed...
May 3, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29721920/acquired-peripheral-pulmonary-artery-aneurysms-morphological-spectrum-of-disease-and-multidetector-computed-tomography-angiography-findings-cases-series-and-literature-review
#7
REVIEW
Tullio Valente, Ahmad Abu-Omar, Giacomo Sica, Alfredo Clemente, Massimo Muto, Giorgio Bocchini, Salvatore Cappabianca, Gaetano Rea
BACKGROUND: Acquired peripheral or intraparenchymal pulmonary artery aneurysms (PPAA) are rare entities but are important to recognize because of the associated morbidity. Hemoptysis is their principal complication and is a potentially fatal condition. PURPOSE: To illustrate the causes, multidetector CT angiography (MDCTA) findings and differential diagnosis of acquired PPAA. MATERIALS AND METHODS: The institutional review boards approved this study...
May 2, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29708283/trichilemmal-cyst-clinical-and-sonographic-features
#8
Ping He, Li-Gang Cui, Jin-Rui Wang, Bo Zhao, Wen Chen, Yan Xu
OBJECTIVES: In this study, we retrospectively reviewed the clinical and sonographic features of patients with trichilemmal cysts. METHODS: Sonographic findings of 54 cases of trichilemmal cysts were retrospectively analyzed from 50 patients, including 4 cases of proliferating trichilemmal cysts. Associated factors of internal calcification-positive cases were also evaluated. RESULTS: The mean age of the 50 patients was 43.4 years (range, 15-80 years) and the female-to-male ratio was 1...
April 30, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29692537/brown-fat-necrosis-with-calcifications-in-the-newborn-risk-factors-radiographic-findings-and-clinical-course
#9
Eleza T Golden, Paula Dickson, Stephen Simoneaux
Objective: To describe the radiographic appearance of subclinical calcified brown fat necrosis and the associated clinical and laboratory findings. Materials and Methods: Picture Archiving and Communications Sytem (PACS) was searched using keywords "soft tissue calcification" and "chest." The clinical record was searched for prior cardiac surgery, bypass, Extracorporeal Membrane Oxygentation (ECMO) and prostaglandin use. Age when calcifications were first detected, location, resolution, and associated laboratory abnormalities were recorded...
January 2018: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29684308/fracture-healing-and-bone-remodeling-with-human-standard-sized-magnesium-versus-polylactide-co-glycolide-plate-and-screw-systems-using-a-mini-swine-craniomaxillofacial-osteotomy-fixation-model
#10
Benoît Schaller, John Patrik Matthias Burkhard, Madeleine Chagnon, Stefan Beck, Thomas Imwinkelried, Michel Assad
PURPOSE: This study compared the degradation profile, safety, and efficacy of bioresorbable magnesium alloy and polylactide-co-glycolide (PLGA) polymer osteosynthesis systems for the treatment of fractures in a load-sharing maxillofacial environment using a new mini-swine fracture fixation model. MATERIALS AND METHODS: Two types of clinically relevant situations were evaluated in 5 Yucatan miniature pigs. Defined porcine midface osteotomies of the supraorbital rim and zygoma were created and fixed with either a coated magnesium (test animals) or PLGA plate and screw osteosynthesis system (control animals)...
March 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29675364/ct-and-mri-of-superficial-solid-tumors
#11
REVIEW
Jingfeng Zhang, Yanyuan Li, Yilei Zhao, Jianjun Qiao
Superficial solid masses are common conditions in clinical practice, however, some of which can be easily diagnosed and others would be difficult. Although imaging of superficial masses is not always characteristic, it would be helpful to give a definitive diagnosis or narrow a differential diagnosis. Crossing-section imaging can depicture the masses directly, find some pathognomonic signs and demonstrate their relationship with adjacent structures, which can provide decision support for clinician's reference...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29671572/aggregation-induced-emission-probe-for-light-up-and-in-situ-detection-of-calcium-ions-at-high-concentration
#12
Meng Gao, Yunxia Li, Xiaohui Chen, Shiwu Li, Li Ren, Ben Zhong Tang
The fluorescent probe for the detection of calcium ions is an indispensable tool in the biomedical field. The millimolar order of Ca(II) ions is associated with many physiological processes and diseases, such as hypercalcemia, soft tissue calcification, and bone microcracks. However, the conventional fluorescent probes are only suitable for imaging Ca(II) ions in the nanomolar to micromolar range, which can be because of their high affinities toward Ca(II) ions and aggregation-caused quenching drawbacks. To tackle this challenge, we herein develop an aggregation-induced emission (AIE) probe SA-4CO2 Na for selective and light-up detection of Ca(II) ions in the millimolar range (0...
April 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29609668/radiopacities-of-the-jaws-interpretation-and-diagnosis
#13
David Andrew
General dental practitioners are less confident at diagnosing radiopaque lesions of the jaws than radiolucent ones, possibly because the incidence of jaw radiopacities is comparatively low. The current review covers the majority of radiopaque lesions that are referred for a specialist opinion, and focuses on those lesions that occur commonly or those that mimic other diagnoses. The majority of radiopaque jaw lesions represent normal anatomy/normal variants or superimposed soft tissue calcifications that are typically of no clinical significance...
March 1, 2018: Primary Dental Journal
https://www.readbyqxmd.com/read/29594503/hyperphosphatemic-tumoral-calcinosis-caused-by-fgf23-compound-heterozygous-mutations-what-are-the-therapeutic-options-for-a-better-control-of-phosphatemia
#14
Debora Claramunt-Taberner, Aurélia Bertholet-Thomas, Marie-Christine Carlier, Frédérique Dijoud, Franck Chotel, Caroline Silve, Justine Bacchetta
BACKGROUND: Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare autosomal recessive disease caused by mutations in genes encoding FGF23 or its regulators, and leading to functional deficiency or resistance to fibroblast growth factor 23 (FGF23). Subsequent biochemical features include hyperphosphatemia due to increased renal phosphate reabsorption, and increased or inappropriately normal 1,25-dihydroxyvitamin D (1,25-D) levels. CASE-DIAGNOSIS/TREATMENT: A 15-year-old girl was referred for a 1...
March 28, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29587781/ossifying-fibromyxoid-tumor-of-soft-parts-in-head-and-neck-case-report-and-literature-review
#15
Ignacio A Velasco, Ran Zhang, Tiejun Li, Diancan Wang
BACKGROUND: Ossifying fibromyxoid tumor of soft parts (OFMT), is a rare but morphologically distinctive neoplasm of uncertain histogenesis that most frequently affects middle-aged male adults. Clinically, it usually presents as a slowly enlarging, small, circumscribed mass, which in most cases is painless. OFMT is most frequently found within the subcutaneous tissues of extremities or trunk, and rarely in the oral/head and neck region. We present an unusual case of this tumor in the submandibular region, and, based on the current medical literatures this is probably the first case described in this anatomical location...
March 27, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29576863/curious-case-of-a-calcified-food-bolus
#16
Andrew D Hart-Pinto, Rashid Sheikh, David Luff
Authors present an 80-year-old male attending with obstructive food bolus. Lateral soft tissue neck x-ray demonstrated a suspected calcified foreign body at the level of the larynx. Subsequent senior radiological input reported the findings as incidental calcification of carotid arteries. ENT surgeons should demonstrate increased awareness for potentially calcified soft tissues on interpreting such x-rays.
March 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29556389/primary-castleman-s-disease-in-the-liver-a-case-report-and-literature-review
#17
Kun Lv, Chun-Li Zhang, Mao-Sheng Xu
Castleman's disease (CD) is a lymphoproliferative abnormality, also referred to as giant lymph node hyperplasia or follicular lymphoid hyperplasia. The occurrence of CD in the liver is rare. Radiological diagnosis of hepatic CD by computed tomography (CT) and magnetic resonance imaging (MRI) remains difficult. On imaging, hepatic CD is often expressed as a single, well-defined soft tissue lesion, with rare cystic degeneration and focal necrosis. The CD lesions appear as hypervascular with abundant cell proliferation on CT and MRI...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29546793/resection-of-puncture-site-necrosis-over-an-arteriovenous-fistula-endoclamp-use-for-preservation-of-cannulation-sites
#18
Alexandros Mallios, William Jennings, Benoit Boura, Alessandro Costanzo, Myriam Combes
Skin necrosis overlying an arteriovenous fistula at the cannulation site is a common and potentially life-threatening problem, often associated with underlying aneurysm formation. Arteriovenous fistula-skin necrosis generally requires resection of surrounding skin margins and the underlying aneurysmal vessel wall, allowing repair with healthy tissue of the arteriovenous fistula in addition to closure of soft tissue and skin. In patients with insufficient fistula length, salvage of these arteriovenous fistulas may result in difficult or insurmountable cannulation issues leading to attempts at one-needle cannulation dialysis or, most often, catheter placement...
May 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29541786/osteoid-osteoma-of-the-scaphoid-bone-associated-with-flexor-carpi-radialis-calcific-tendinitis-and-treated-with-ct-guided-rf-ablation
#19
Michalis Michaelides, Elena Drakonaki, Elia Petridou, Maria Pantziara, Cleanthis Ioannides
Osteoid osteomas of the wrist are relatively rare and the diagnosis is challenging due to atypical clinical features. We describe a case of an osteoid osteoma of the scaphoid bone associated with calcific tendinitis of the adjacent flexor carpi radialis tendon and periarticular soft tissue calcifications in a 21-year-old man presenting with radial-sided wrist pain. The lesion was successfully treated with CT-guided RF ablation. To our knowledge, this is the first description of an osteoid osteoma of the wrist associated with calcific tendinitis and periarthritis...
March 14, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29521119/soft-tissue-calcifications-secondary-to-hymenoptera-stings-a-potential-prognostic-ct-imaging-sign-in-pediatric-patients
#20
Wen-Jun Liu, Wei Li, Yang Tang, Si-Jie Gao, Fang Fang, Feng Xu, Ye Xu
CONTEXT: Soft tissue calcifications (STCs) were incidentally found in some of the Hymenoptera-stung (HS) children when they underwent computed tomography (CT) scans for evaluating complications of vital organs. Afterwards, a predilection of STCs to the children with severe complications was clinically noticed. A hypothesis was then developed that STCs secondary to HS may correlate with poor outcomes. OBJECTIVE: This study aims to firstly characterize the CT findings of STCs in HS children and to confirm our hypothesis that the occurrence of STCs may act as an indicator of poor outcomes in HS children...
March 9, 2018: Clinical Toxicology
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