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https://www.readbyqxmd.com/read/28541699/kohamamides-a-b-and-c-cyclic-depsipeptides-from-an-okeania-sp-marine-cyanobacterium
#1
Arihiro Iwasaki, Ikuma Shiota, Shimpei Sumimoto, Teruhiko Matsubara, Toshinori Sato, Kiyotake Suenaga
Kohamamides A, B, and C (1-3), new cyclic depsipeptides that belong to the kulolide superfamily, were isolated from an Okeania sp. marine cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Kohamamide B (2) exhibited moderate cytotoxicity against HL60 cells. Although many natural products in the kulolide superfamily have been isolated from cyanobacteria collected in various parts of the world, kohamamides 1-3 are the first members to be isolated from the East Asian marine environment...
May 25, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28541666/unveiling-the-molecular-structure-of-pulmonary-surfactant-corona-on-nanoparticles
#2
Qinglin Hu, Xuan Bai, Guoqing Hu, Yi Y Zuo
The growing risk of human exposure to airborne nanoparticles (NPs) causes a general concern on the biosafety of nanotechnology. Inhaled NPs can deposit in the deep lung at which interacting with the pulmonary surfactant (PS). Despite the increasing study of nano-bio interactions, detailed molecular mechanisms by which inhaled NPs interact with the natural PS system remain unclear. Using coarse-grained molecular dynamics simulation, we studied the interaction between NPs and the PS system in the alveolar fluid...
May 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28540997/a-combination-of-short-and-simple-surfactant-protein-b-and-c-analogues-as-a-new-synthetic-surfactant-in-vitro-and-animal-experiments
#3
Yong Sung Choi, Sung Hoon Chung, Chong Woo Bae
PURPOSE: Pulmonary surfactants for preterm infants contain mostly animal-derived surfactant proteins (SPs), which are essential for lowering surface tension. We prepared artificial pulmonary surfactants using synthetic human SP analogs and performed in vitro and in vivo experiments. MATERIALS AND METHODS: We synthesized peptide analogues that resemble human SP-B (RMLPQLVCRLVLRCSMD) and SP-C (CPVHLKRLLLLLLLLLLLLLLLL). Dipalmitoylphosphatidylcholine (DPPC), phosphatidylglycerol (PG), and palmitic acid (PA) were added and mixed in lyophilized to render powdered surfactant...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28540551/zif-8-derived-nitrogen-doped-porous-carbon-as-metal-free-catalyst-of-peroxymonosulfate-activation
#4
Wenjie Ma, Yunchen Du, Na Wang, Peng Miao
Nitrogen-doped porous carbon (NPC) is synthesized through a direct pyrolysis of zeolitic imidazolate framework (ZIF)-8 under N2 flow followed by acid washing process. It is found that NPC-800 pyrolyzed at 800 °C can inherit the perfect rhombic dodecahedron morphology of ZIF-8 crystals and achieve the considerable nitrogen-doping content of 15.20%. When NPC-800 is applied as the heterogeneous catalyst in peroxymonosulfate (PMS) activation for the degradation of Rhodamine B (RhB) and phenol, NPC-800 will exhibit its better performance than some conventional transition metal-based oxides and common carbon materials...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28539221/lodopyridones-b-and-c-from-a-marine-sediment-derived-bacterium-saccharomonospora-sp
#5
Tu Cam Le, Chae-Yoon Yim, Songhee Park, Nikita Katila, Inho Yang, Myeong Chong Song, Yeo Joon Yoon, Dong-Young Choi, Hyukjae Choi, Sang-Jip Nam, William Fenical
HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules...
May 12, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28536867/suppressing-effect-of-cor659-on-alcohol-sucrose-and-chocolate-self-administration-in-rats-involvement-of-the-gabab-and-cannabinoid-cb1-receptors
#6
Paola Maccioni, Giancarlo Colombo, Irene Lorrai, Alessandro Zaru, Mauro A M Carai, Gian Luigi Gessa, Antonella Brizzi, Claudia Mugnaini, Federico Corelli
RATIONALE AND OBJECTIVES: COR659 [methyl2-(4-chlorophenylcarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate] is a new, positive allosteric modulator (PAM) of the GABAB receptor. This study evaluated whether COR659 shared with previously tested GABAB PAMs the capacity to reduce alcohol self-administration in rats. RESULTS: Treatment with non-sedative doses of COR659 (2.5, 5, and 10 mg/kg; i.p.) suppressed lever-responding for alcohol (15% v/v) in Sardinian alcohol-preferring (sP) rats under the fixed ratio (FR) 4 (FR4) and progressive ratio (PR) schedules of reinforcement; COR659 was more potent and effective than the reference GABAB PAM, GS39783...
May 24, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28525332/distribution-and-immunohistochemical-characteristics-of-cocaine-and-amphetamineregulated-transcript-positive-nerve-elements-in-the-pelvic-ganglia-of-the-female-pig
#7
A Zacharko-Siembida, M Matysek, R Szalak, A Radlińska, K Obszańska, M B Arciszewski
Cocaine- and amphetamine-regulated transcript (CART) peptides are widely expressed not only in the brain but also in numerous endocrine/neuroendocrine cells as well as in neurons of the peripheral nervous system. The present study investigated the distribution patterns of CART-like immunoreactivity in the pelvic plexus (PP) of the female pig. The co-expression of CART with principal neurotransmitter markers: choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), serotonin (5-HT) or biologically active neuropeptides: pituitary adenylate cyclase-activating polypeptide (PACAP), substance P (SP), calbindin was analyzed using double immunohistochemical stainings...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28524870/autotrophic-and-heterotrophic-acquisition-of-carbon-and-nitrogen-by-a-mixotrophic-chrysophyte-established-through-stable-isotope-analysis
#8
Ramon Terrado, Alexis L Pasulka, Alle A-Y Lie, Victoria J Orphan, Karla B Heidelberg, David A Caron
Collectively, phagotrophic algae (mixotrophs) form a functional continuum of nutritional modes between autotrophy and heterotrophy, but the specific physiological benefits of mixotrophic nutrition differ among taxa. Ochromonas spp. are ubiquitous chrysophytes that exhibit high nutritional flexibility, although most species generally fall towards the heterotrophic end of the mixotrophy spectrum. We assessed the sources of carbon and nitrogen in Ochromonas sp. strain BG-1 growing mixotrophically via short-term stable isotope probing...
May 19, 2017: ISME Journal
https://www.readbyqxmd.com/read/28524627/weight-loss-interventions-and-gut-microbiota-changes-in-overweight-and-obese-patients-a-systematic-review
#9
REVIEW
F B Seganfredo, C A Blume, M Moehlecke, A Giongo, D S Casagrande, J V N Spolidoro, A V Padoin, B D Schaan, C C Mottin
Imbalances in the gut microbiota, the bacteria that inhabit the intestines, are central to the pathogenesis of obesity. This systematic review assesses the association between the gut microbiota and weight loss in overweight/obese adults and its potential manipulation as a target for treating obesity. This review identified 43 studies using the keywords 'overweight' or 'obesity' and 'microbiota' and related terms; among these studies, 17 used dietary interventions, 11 used bariatric surgery and 15 used microbiota manipulation...
May 19, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28513734/strained-alkynes-derived-from-2-2-dihydroxy-1-1-biaryls-synthesis-and-copper-free-cycloaddition-with-azides
#10
Alessandro Del Grosso, Lavrentis-Dimitrios Galanopoulos, Cookson K C Chiu, Guy J Clarkson, Peter B O Connor, Martin Wills
A series of strained alkynes were prepared from 2,2'-dihydroxy-biaryls. Several were characterised by X-ray crystallography, revealing strained C(sp)-C(sp)-C(sp(3)) bond angles in the range of 163-167°. Their cycloadditions with azides proceed without a catalyst. Functionalised versions of these reagents have potential applications to materials synthesis and bioconjugations.
May 17, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28510248/cadm1-mrna-expression-and-clinicopathological-significance-in-esophageal-squamous-cell-carcinoma-tissue
#11
J B Qian, H B Liu, Y Zhu, F Lu, Q C Yang, Y Shen
The mRNA expression of cell adhesion molecule 1 (CADM1) and its clinicopathological significance in esophageal squamous cell carcinoma (ESCC) tissues were investigated. CADM1 mRNA and protein expression were detected in tissue samples from 50 patients with ESCC by reverse transcription-polymerase chain reaction (RT-PCR) and streptavidin-peroxidase (SP) immunohistochemistry; adjacent tissues served as controls. The average CADM1 mRNA expression was significantly downregulated in the cancer tissues (0.522 ± 0...
May 10, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28506539/description-of-a-new-soft-tick-species-acari-argasidae-ornithodoros-associated-with-stream-breeding-frogs-anura-cycloramphidae-cycloramphus-in-brazil
#12
Sebastián Muñoz-Leal, Luís Felipe Toledo, José M Venzal, Arlei Marcili, Thiago F Martins, Igor C L Acosta, Adriano Pinter, Marcelo B Labruna
In this study, we present a morphological description of immature and adult specimens of Ornithodoros saraivai n. sp., a tick associated with the frog Cycloramphus boraceiensis (Cycloramphidae) at São Sebastião island, located in the São Paulo state seaboard, Brazil. While larvae of O. saraivai are ecologically related to Ornithodoros faccinii, another soft tick associated with cycloramphids, the combination of 7 sternal pairs, 16 dorsal pairs, a pyriform dorsal plate and a partially toothed hypostome constitute unique characters of the O...
May 10, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28505534/discorhabdin-alkaloids-from-antarctic-latrunculia-spp-sponges-as-a-new-class-of-cholinesterase-inhibitors
#13
Tanja Botić, Andrea Defant, Pietro Zanini, Monika Cecilija Žužek, Robert Frangež, Dorte Janussen, Daniel Kersken, Željko Knez, Ines Mancini, Kristina Sepčić
The brominated pyrroloiminoquinone alkaloids discorhabdins B, L and G and 3-dihydro-7,8- dehydrodiscorhabdin C, isolated from methanol extracts of two specimens of Latrunculia sp. sponges collected near the Antarctic Peninsula, are here demonstrated for the first time to be reversible competitive inhibitors of cholinesterases. They showed Ki for electric eel acetylcholinesterase of 1.6-15.0 μM, for recombinant human acetylcholinesterase of 22.8-98.0 μM, and for horse serum butyrylcholinesterase of 5.0-76...
May 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28504888/cytotoxic-bagremycins-from-mangrove-derived-streptomyces-sp-q22
#14
Lei Chen, Weiyun Chai, Wenling Wang, Tengfei Song, Xiao-Yuan Lian, Zhizhen Zhang
New bagremycins C-E (3-5) and bagrelactone A (6), together with known bagremycins A (1) and B (2), 4-hydroxystyrene (7), and 4-hydroxystyrene 4-O-α-d-galactopyranoside (8), were isolated from a mangrove-derived actinomycete, Streptomyces sp. Q22. Structures of these new compounds were elucidated based on their NMR and HRESIMS spectroscopic data as well as chemical degradation. Bagremycin C (3) is a unique analogue with an N-acetyl-(S)-cysteine moiety, while bagrelactone A (6) represents the first example of this type of bagremycin-derived macrolide...
May 15, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28504092/mycoplasma-sp-infection-in-captive-marcgrave-s-capuchin-monkeys-sapajus-flavius
#15
Ayodhya C Ramalho, Ricardo R Guerra, Anna C B Mongruel, Odilon Vidotto, Ricardo B Lucena, Monalisa V S F Guerra, Thállitha S W J Vieira, Rafael F C Vieira
Three species of hemoplasmas are known to infect monkeys, 'Candidatus Mycoplasma kahanei', 'Candidatus Mycoplasma haemomacaque' and 'Candidatus Mycoplasma aoti'. Marcgrave's capuchin monkey (Sapajus flavius) is a critically endangered neotropical primate species of the Brazilian Atlantic Forest, and thus, sustained efforts are needed to protect the health and well-being of these animals. This study has aimed to screen 12 captive S. flavius from the State of Paraíba, northeastern Brazil, for hemoplasma infection...
April 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28500046/roxb-is-a-novel-type-of-rubber-oxygenase-that-combines-properties-of-rubber-oxygenase-roxa-and-latex-clearing-protein-lcp
#16
Jakob Birke, Wolf Röther, Dieter Jendrossek
Only two types of rubber oxygenases, rubber oxygenase (RoxA) and latex clearing protein (Lcp), have been described so far. RoxAs are c-type cytochromes of ≈70 kDa produced by Gram-negative rubber-degrading bacteria and cleave polyisoprene into 12-oxo-4,8-dimethyltrideca-4,8-diene-1-al (ODTD), a C15 oligo-isoprenoid, as major end product. Lcps are common among Gram-positive rubber-degraders and don't share amino acid sequence similarities with RoxA proteins (RoxAs). Furthermore, Lcps have much smaller molecular masses (≈40 kDa), are b-type cytochromes and cleave polyisoprene to a mixture of C20, C25, C30 and higher oligo-isoprenoids as end products...
May 12, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28495874/cranking-up-the-heat-relationships-between-energetically-costly-song-features-and-the-increase-in-thorax-temperature-in-male-crickets-and-katydids
#17
B Erregger, H Kovac, A Stabentheiner, M Hartbauer, H Römer, A K D Schmidt
Sexual displays of acoustically signalling insects are used in the context of mate attraction and mate choice. While energetic investment in sound production can increase the reproductive success of the sender, this entails metabolic costs. Resource allocation into sexually selected, reproductive traits can trade off against allocation to naturally selected traits (e.g., growth, immunity) when individuals' energy budgets are limited. Estimating the magnitude of the costs invested in acoustic signalling is necessary to understand this trade-off and its influence on fitness and life-history...
May 11, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28492083/b-c6f5-3-catalyzed-michael-reactions-aromatic-c-h-as-nucleophiles
#18
Wu Li, Thomas Werner
The Michael reaction is a widely used reaction for the C-C coupling of electron-poor olefins and C(sp(3))-H pronucleophiles. Herein we report the Michael reaction between alkenes and aromatic as well as heteroaromatic compounds as aromatic C(sp(2))-H nucleophiles under mild conditions. The reaction is catalyzed by readily available Lewis acidic B(C6F5)3 and proceeds with high regioselectivity for a wide substrate scope.
May 11, 2017: Organic Letters
https://www.readbyqxmd.com/read/28489377/svetamycins-a-g-unusual-piperazic-acid-containing-peptides-from-streptomyces-sp
#19
Denis Dardic, Gianluigi Lauro, Giuseppe Bifulco, Patricia Laboudie, Peyman Sakhaii, Armin Bauer, Andreas Vilcinskas, Peter E Hammann, Alberto Plaza
Seven new halogenated peptides termed svetamycins A-G (1-7) have been isolated from laboratory cultures of a Streptomyces sp. Svetamycins A-D, F, and G are cyclic depsipeptides whereas svetamycin E is a linear analogue of svetamycin C. Their structures were determined using extensive spectroscopic analysis, and their stereochemical configuration was established by a combination of NMR data, quantum mechanical calculations, and chemical derivatizations. Svetamycins are characterized by the presence of a hydroxyl acetic acid and five amino acids including a rare 4,5-dihydroxy-2,3,4,5-tetrahydropyridazine-3-carboxylic acid, a γ-halogenated piperazic acid, and a novel δ-methylated piperazic acid in svetamycins B-C, E, and G...
May 10, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28486007/concomitant-laparoscopic-perisplenic-artery-ligation-facilitates-surgery-for-hepatobiliary-disease-coexisting-with-portal-hypertension
#20
Youlong Wang, Fei Chen, Yajuan Chu, Xiaofang Tan, Jingwang Tan, Wenbin Ji
BACKGROUND: Although liver cirrhosis with portal hypertension (PH) contributes significantly to morbidity and mortality in abdominal surgery, many authors still consider this disease as an indication for surgery. In many reports, however, numerous treatment modalities focus on hypersplenism secondary to PH, irrespective of splenomegaly and PH. The proven benefits of laparoscopy seem especially applicable to patients with this complex disease. This study evaluates the safety and efficacy of laparoscopic perisplenic artery ligation (SAL) in patients with hepatobiliary disease and PH...
May 9, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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