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https://www.readbyqxmd.com/read/28417271/antimicrobial-effects-of-manuka-honey-on-in-vitro-biofilm-formation-by-clostridium-difficile
#1
M Piotrowski, P Karpiński, H Pituch, A van Belkum, P Obuch-Woszczatyński
Clostridium difficile is the cause of the nosocomial C. difficile infection (CDI). The conventional antibiotics used in CDI therapy are often unsuccessful, and recurrent infections may occur. Biofilm formation by C. difficile is associated with chronic or recurrent infections; biofilms may contribute to virulence and impaired antimicrobial efficacy. Manuka honey, derived from the Manuka tree (Leptospermum scoparium), is known to exhibit antimicrobial properties that are associated with its significant content of methylglyoxal, a natural antibiotic...
April 18, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28415841/unique-pattern-of-protein-bound-maillard-reaction-products-in-manuka-leptospermum-scoparium-honey
#2
Michael Hellwig, Jana Rückriemen, Daniel Sandner, Thomas Henle
As a unique feature, honey from the New Zealand manuka tree (Leptospermum scoparium) contains substantial amounts of dihydroxyacetone (DHA) and methylglyoxal (MGO). Although MGO is a reactive intermediate in the Maillard reaction, very little is known about reactions of MGO with honey proteins. We hypothesized that the abundance of MGO should result in a particular pattern of protein-bound Maillard reaction products (MRPs) in manuka honey. A protein-rich high-molecular-weight fraction was isolated from 12 manuka and 8 non-manuka honeys and hydrolyzed enzymatically...
April 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28407946/manuka-honey-leptospermum-scoparium-inhibits-jack-bean-urease-activity-due-to-methylglyoxal-and-dihydroxyacetone
#3
Jana Rückriemen, Oliver Klemm, Thomas Henle
Manuka honey (Leptospermum scoparium) exerts a strong antibacterial effect. Bacterial enzymes are an important target for antibacterial compounds. The enzyme urease produces ammonia and enables bacteria to adapt to an acidic environment. A new enzymatic assay, based on photometric detection of ammonia with ninhydrin, was developed to study urease activity. Methylglyoxal (MGO) and its precursor dihydroxyacetone (DHA), which are naturally present in manuka honey, were identified as jack bean urease inhibitors with IC50 values of 2...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28392803/periodontal-application-of-manuka-honey-antimicrobial-and-demineralising-effects-in-vitro
#4
Syarida H Safii, Geoffrey R Tompkins, Warwick J Duncan
Background. Topical application of manuka honey is effective in the treatment of burns and soft-tissue infections. The aim of this study was to assess the antibacterial activity of manuka honey against plaque-associated bacteria in vitro in order to evaluate the potential application as an adjunct to periodontal treatment. Materials and Methods. The minimum bacteriostatic and bactericidal concentrations (MIC and MBC) of manuka honey were compared to those of white clover honey against a variety of plaque-associated bacteria, at the natural and neutral pH...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28326322/a-comparison-of-tissue-engineering-scaffolds-incorporated-with-manuka-honey-of-varying-umf
#5
Katherine R Hixon, Tracy Lu, Sarah H McBride-Gagyi, Blythe E Janowiak, Scott A Sell
Purpose. Manuka honey (MH) is an antibacterial agent specific to the islands of New Zealand containing both hydrogen peroxide and a Unique Manuka Factor (UMF). Although the antibacterial properties of MH have been studied, the effect of varying UMF of MH incorporated into tissue engineered scaffolds have not. Therefore, this study was designed to compare silk fibroin cryogels and electrospun scaffolds incorporated with a 5% MH concentration of various UMF. Methods. Characteristics such as porosity, bacterial clearance and adhesion, and cytotoxicity were compared...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28287735/targeted-antibiotic-delivery-selective-siderophore-conjugation-with-daptomycin-confers-potent-activity-against-multidrug-resistant-acinetobacter-baumannii-both-in-vitro-and-in-vivo
#6
Manuka Ghosh, Patricia A Miller, Ute Möllmann, William D Claypool, Valerie A Schroeder, William R Wolter, Mark Suckow, Honglin Yu, Shuang Li, Weiqiang Huang, Jaroslav Zajicek, Marvin J Miller
In order to address the dire need for new antibiotics to treat specific strains of drug resistant Gram-negative bacterial infections, a mixed ligand analog of the natural Acinetobacter baumannii selective siderophore, fimsbactin, was coupled to daptomycin, a Gram-positive only antibiotic. The resulting conjugate 11 has potent activity against multidrug resistant strains of A. baumannii both in vitro and in vivo. The study also indicates that conjugation of siderophores to "drugs" that are much larger than the siderophore (iron transport agent) itself facilitates active uptake that circumvents the normal permeability problems in Gram-negative bacteria...
April 1, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28287469/strawberry-tree-honey-induces-growth-inhibition-of-human-colon-cancer-cells-and-increases-ros-generation-a-comparison-with-manuka-honey
#7
Sadia Afrin, Tamara Y Forbes-Hernandez, Massimiliano Gasparrini, Stefano Bompadre, José L Quiles, Gavino Sanna, Nadia Spano, Francesca Giampieri, Maurizio Battino
Honey is a natural product known to modulate several biological activities including cancer. The aim of the present study was to examine the phytochemical content and the antioxidant activity of Strawberry tree (Arbutus unedo) honey (STH) and its cytotoxic properties against human colon adenocarcinoma (HCT-116) and metastatic (LoVo) cell lines in comparison with Manuka (Leptospermum scoparium) honey (MH). Several unifloral STH and MH were analyzed for their phenolic, flavonoid, amino acid and protein contents, as well as their radical scavenging activities...
March 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28250794/manuka-honey-exerts-antioxidant-and-anti-inflammatory-activities-that-promote-healing-of-acetic-acid-induced-gastric-ulcer-in-rats
#8
Saad B Almasaudi, Aymn T Abbas, Rashad R Al-Hindi, Nagla A El-Shitany, Umama A Abdel-Dayem, Soad S Ali, Rasha M Saleh, Soad K Al Jaouni, Mohammad Amjad Kamal, Steve M Harakeh
Gastric ulcers are a major problem worldwide with no effective treatment. The objective of this study was to evaluate the use of manuka honey in the treatment of acetic acid-induced chronic gastric ulcers in rats. Different groups of rats were treated with three different concentrations of honey. Stomachs were checked macroscopically for ulcerative lesions in the glandular mucosa and microscopically for histopathological alterations. Treatment with manuka honey significantly reduced the ulcer index and maintained the glycoprotein content...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28244415/a-randomized-phase-2-trial-of-prophylactic-manuka-honey-for-the-reduction-of-chemoradiation-therapy-induced-esophagitis-during-the-treatment-of-lung-cancer-results-of-nrg-oncology-rtog-1012
#9
Shannon E Fogh, Snehal Deshmukh, Lawrence B Berk, Amylou C Dueck, Kevin Roof, Sherif Yacoub, Thomas Gergel, Kevin Stephans, Andreas Rimner, Albert DeNittis, John Pablo, Justin Rineer, Terence M Williams, Deborah Bruner
PURPOSE: Randomized trials have shown that honey is effective for the prevention of radiation-induced mucositis in head and neck cancer patients. Because there is no efficacious preventative for radiation esophagitis in lung cancer patients, this trial compared liquid honey, honey lozenges, and standard supportive care for radiation esophagitis. METHODS: The patients were stratified by percentage of esophagus receiving specific radiation dose (V60 Gy esophagus <30% or ≥30%) and were then randomized between supportive care, 10 mL of liquid manuka honey 4 times a day, and 2 lozenges (10 mL of dehydrated manuka honey) 4 times a day during concurrent chemotherapy and radiation therapy...
March 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28239398/a-pilot-randomized-controlled-study-of-nanocrystalline-silver-manuka-honey-and-conventional-dressing-in-healing-diabetic-foot-ulcer
#10
Ka-Kit Tsang, Enid Wai-Yung Kwong, Tony Shing-Shun To, Joanne Wai-Yee Chung, Thomas Kwok-Shing Wong
Nanocrystalline silver (nAg) and Manuka honey (MH) dressing have increasing popularity for treating diabetic foot ulcer (DFU). This study was an open-label randomized controlled trial with three parallel groups' design in examining the preliminary effectiveness of nAg against MH and conventional dressing in healing DFU in terms of ulcer healing, ulcer infection, and inflammation. 31 participants (11 in the nAg group, 10 in the MH group, and 10 in the convention group) diagnosed with type 2 diabetes were enrolled...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28238430/response-of-leptospermum-scoparium-kunzea-robusta-and-pinus-radiata-to-contrasting-biowastes
#11
J Esperschuetz, C Anderson, S Bulman, O Katamian, J Horswell, N M Dickinson, B H Robinson
The myrtaceae family has a cosmopolitan distribution and includes the Australasian native species Leptospermum scoparium (mānuka) and Kunzea robusta (kānuka), which are of economic interest for the production of high-value honey and essential oils. Potentially, these species could be established on low-fertility or degraded soils that have been amended with biowastes, including biosolids and sawdust. We aimed to determine the effect of these biowastes on nitrate leaching and the growth and chemical composition of these plant species compared to Pinus radiata (pine), a common forestry species...
February 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28193412/lepteridine-as-a-unique-fluorescent-marker-for-the-authentication-of-manuka-honey
#12
Bin Lin, Kerry M Loomes, Gordana Prijic, Ralf Schlothauer, Jonathan M Stephens
The recent discovery of two unique manuka marker fluorescence wavelengths (MM1 and MM2) potentially offers a rapid and cost-effective approach for manuka honey authentication using spectroscopy. The fluorophore responsible for the MM1 marker has been identified as leptosperin. We investigated whether lepteridine may be responsible for the MM2 fluorescence. We quantified the lepteridine in manuka honey and manuka nectar, which ranged between 5-52mg/kg and 80-205mg/kg, respectively. Notably, the fluorescent spectrum of synthetic lepteridine matched the MM2 fluorescence signature...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28174146/antibacterial-activities-of-manuka-and-honeydew-honey-based-membranes-against-bacteria-that-cause-wound-infections-in-animals
#13
C Tramuta, P Nebbia, P Robino, G Giusto, M Gandini, S Chiadò-Cutin, E Grego
In this study, membranes composed of honey (Manuka or Honeydew) and pectin were developed, and the ISO 22196 method was used to evaluate their antibacterial activities against multidrug-resistant bacteria (i.e., Staphylococcus pseudointermedius, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa) that cause wound infection in animals. The results demonstrated that both Manuka and Honeydew honey-based membranes had strong antibacterial activities against the strain of methicillin-resistant S. pseudointermedius tested...
February 2017: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/28030589/the-antibacterial-activity-of-australian-leptospermum-honey-correlates-with-methylglyoxal-levels
#14
Nural N Cokcetin, Matthew Pappalardo, Leona T Campbell, Peter Brooks, Dee A Carter, Shona E Blair, Elizabeth J Harry
Most commercially available therapeutic honey is derived from flowering Leptospermum scoparium (manuka) plants from New Zealand. Australia has more than 80 Leptospermum species, and limited research to date has found at least some produce honey with high non-peroxide antibacterial activity (NPA) similar to New Zealand manuka, suggesting Australia may have a ready supply of medical-grade honey. The activity of manuka honey is largely due to the presence of methylglyoxal (MGO), which is produced non-enzymatically from dihydroxyacetone (DHA) present in manuka nectar...
2016: PloS One
https://www.readbyqxmd.com/read/28028466/consumption-of-antimicrobial-manuka-honey-does-not-significantly-perturb-the-microbiota-in-the-hind-gut-of-mice
#15
Doug Rosendale, Christine A Butts, Cloe Erika de Guzman, Ian S Maddox, Sheridan Martell, Lynn McIntyre, Margot A Skinner, Hannah Dinnan, Juliet Ansell
The aim of this study was to test the hypothesis that consuming manuka honey, which contains antimicrobial methylglyoxal, may affect the gut microbiota. We undertook a mouse feeding study to investigate whether dietary manuka honey supplementation altered microbial numbers and their production of organic acid products from carbohydrate fermentation, which are markers of gut microbiota function. The caecum of C57BL/6 mice fed a diet supplemented with antimicrobial UMF® 20+ manuka honey at 2.2 g/kg animal did not show any significantly changed concentrations of microbial short chain fatty acids as measured by gas chromatography, except for increased formate and lowered succinate organic acid concentrations, compared to mice fed a control diet...
2016: PeerJ
https://www.readbyqxmd.com/read/28024521/a-novel-interpretation-of-the-fractional-inhibitory-concentration-index-the-case-origanum-vulgare-l-and-leptospermum-scoparium-j-r-et-g-forst-essential-oils-against-staphylococcus-aureus-strains
#16
Filippo Fratini, Simone Mancini, Barbara Turchi, Elisabetta Friscia, Luisa Pistelli, Giulia Giusti, Domenico Cerri
Origanum vulgare (oregano) and Leptospermum scoparium (manuka) were traditionally employed as natural remedies for infected wounds and skin injuries where Staphylococcus aureus is mainly involved. The first aim of this study was to investigate oregano and manuka essential oils (EOs) chemical compositions and evaluate their antibacterial activity (MIC, Minimum Inhibitory Concentration) against fourteen S. aureus wild strains. The second aim was to evaluate the antibacterial activities of oregano and manuka EOs mixed in different combination (FIC, Fractional Inhibitory Concentration) with an improved chequerboard technique...
January 2017: Microbiological Research
https://www.readbyqxmd.com/read/27992658/antimicrobial-activity-of-manuka-honey-against-antibiotic-resistant-strains-of-the-cell-wall-free-bacteria-ureaplasma-parvum-and-ureaplasma-urealyticum
#17
K L Hillitt, R E Jenkins, O B Spiller, M L Beeton
The susceptibility of the cell wall-free bacterial pathogens Ureaplasma spp. to Manuka honey was examined. The minimum inhibitory concentration (MIC) of Manuka honey for four Ureaplasma urealyticum and four Ureaplasma parvum isolates was determined. Sensitivity to honey was also compared to clinical isolates with resistance to tetracycline, macrolide and fluoroquinolone antibiotics. Finally step-wise resistance training was utilized in an attempt to induce increased tolerance to honey. The MIC was dependent on the initial bacterial load with 7·5 and 18·0% w/v honey required to inhibit U...
December 19, 2016: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/27935259/manuka-honey-sinus-irrigation-for-the-treatment-of-chronic-rhinosinusitis-a-randomized-controlled-trial
#18
Victoria S Lee, Ian M Humphreys, Patricia L Purcell, Greg E Davis
BACKGROUND: Manuka honey (MH) has been shown in vitro to be effective against biofilm-producing bacteria. This study assessed the effectiveness of MH for patients with active chronic rhinosinusitis (CRS) and prior sinus surgery. METHODS: This prospective single-blinded (clinician only) randomized controlled trial recruited patients with active CRS and prior sinus surgery. Patients received either MH or saline (SAL) sinus irrigations twice daily for 30 days and were offered oral antibiotics and/or oral/topical steroids as indicated...
December 9, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27876081/in-vitro-activity-of-ten-essential-oils-against-sarcoptes-scabiei
#19
Fang Fang, Kerdalidec Candy, Elise Melloul, Charlotte Bernigaud, Ling Chai, Céline Darmon, Rémy Durand, Françoise Botterel, Olivier Chosidow, Arezki Izri, Weiyi Huang, Jacques Guillot
BACKGROUND: The development of alternative approaches in ectoparasite management is currently required. Essential oils have been demonstrated to exhibit fumigant and topical toxicity to a number of arthropods. The aim of the present study was to assess the potential efficacy of ten essential oils against Sarcoptes scabiei. METHODS: The major chemical components of the oils were identified by GC-MS analysis. Contact and fumigation bioassays were performed on Sarcoptes mites collected from experimentally infected pigs...
November 22, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27806565/fluorescent-pteridine-derivatives-as-new-markers-for-the-characterization-of-genuine-monofloral-new-zealand-manuka-leptospermum-scoparium-honey
#20
Nicole Beitlich, Tilo Lübken, Martin Kaiser, Lilit Ispiryan, Karl Speer
New Zealand manuka honey is well-known for its unique antibacterial activity. Due to its high price and limited availability, this honey is often subject to honey fraud. Two pteridine derivatives, 3,6,7-trimethyl-2,4(1H,3H)-pteridinedione and 6,7-dimethyl-2,4(1H,3H)-pteridinedione, have now been identified in New Zealand manuka honey. Their structures were elucidated by LC-QTOF-HRMS, NMR, and single-crystal X-ray diffraction after isolation via semipreparative HPLC. Their marker potential for authentic manuka honey was proved as both substances were detectable in neither the pollen-identical kanuka honey nor the nine other kinds of monofloral New Zealand honey analyzed (clover, forest, kamahi, pohutukawa, rata, rewarewa, tawari, thyme, and vipers bugloss)...
November 23, 2016: Journal of Agricultural and Food Chemistry
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