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https://www.readbyqxmd.com/read/28193412/lepteridine-as-a-unique-fluorescent-marker-for-the-authentication-of-manuka-honey
#1
Bin Lin, Kerry M Loomes, Gordana Prijic, Ralf Schlothauer, Jonathan M Stephens
The recent discovery of two unique manuka marker fluorescence wavelengths (MM1 and MM2) potentially offers a rapid and cost-effective approach for manuka honey authentication using spectroscopy. The fluorophore responsible for the MM1 marker has been identified as leptosperin. We investigated whether lepteridine may be responsible for the MM2 fluorescence. We quantified the lepteridine in manuka honey and manuka nectar, which ranged between 5-52mg/kg and 80-205mg/kg, respectively. Notably, the fluorescent spectrum of synthetic lepteridine matched the MM2 fluorescence signature...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28174146/antibacterial-activities-of-manuka-and-honeydew-honey-based-membranes-against-bacteria-that-cause-wound-infections-in-animals
#2
C Tramuta, P Nebbia, P Robino, G Giusto, M Gandini, S Chiadò-Cutin, E Grego
In this study, membranes composed of honey (Manuka or Honeydew) and pectin were developed, and the ISO 22196 method was used to evaluate their antibacterial activities against multidrug-resistant bacteria (i.e., Staphylococcus pseudointermedius, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa) that cause wound infection in animals. The results demonstrated that both Manuka and Honeydew honey-based membranes had strong antibacterial activities against the strain of methicillin-resistant S. pseudointermedius tested...
February 2017: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/28030589/the-antibacterial-activity-of-australian-leptospermum-honey-correlates-with-methylglyoxal-levels
#3
Nural N Cokcetin, Matthew Pappalardo, Leona T Campbell, Peter Brooks, Dee A Carter, Shona E Blair, Elizabeth J Harry
Most commercially available therapeutic honey is derived from flowering Leptospermum scoparium (manuka) plants from New Zealand. Australia has more than 80 Leptospermum species, and limited research to date has found at least some produce honey with high non-peroxide antibacterial activity (NPA) similar to New Zealand manuka, suggesting Australia may have a ready supply of medical-grade honey. The activity of manuka honey is largely due to the presence of methylglyoxal (MGO), which is produced non-enzymatically from dihydroxyacetone (DHA) present in manuka nectar...
2016: PloS One
https://www.readbyqxmd.com/read/28028466/consumption-of-antimicrobial-manuka-honey-does-not-significantly-perturb-the-microbiota-in-the-hind-gut-of-mice
#4
Doug Rosendale, Christine A Butts, Cloe Erika de Guzman, Ian S Maddox, Sheridan Martell, Lynn McIntyre, Margot A Skinner, Hannah Dinnan, Juliet Ansell
The aim of this study was to test the hypothesis that consuming manuka honey, which contains antimicrobial methylglyoxal, may affect the gut microbiota. We undertook a mouse feeding study to investigate whether dietary manuka honey supplementation altered microbial numbers and their production of organic acid products from carbohydrate fermentation, which are markers of gut microbiota function. The caecum of C57BL/6 mice fed a diet supplemented with antimicrobial UMF® 20+ manuka honey at 2.2 g/kg animal did not show any significantly changed concentrations of microbial short chain fatty acids as measured by gas chromatography, except for increased formate and lowered succinate organic acid concentrations, compared to mice fed a control diet...
2016: PeerJ
https://www.readbyqxmd.com/read/28024521/a-novel-interpretation-of-the-fractional-inhibitory-concentration-index-the-case-origanum-vulgare-l-and-leptospermum-scoparium-j-r-et-g-forst-essential-oils-against-staphylococcus-aureus-strains
#5
Filippo Fratini, Simone Mancini, Barbara Turchi, Elisabetta Friscia, Luisa Pistelli, Giulia Giusti, Domenico Cerri
Origanum vulgare (oregano) and Leptospermum scoparium (manuka) were traditionally employed as natural remedies for infected wounds and skin injuries where Staphylococcus aureus is mainly involved. The first aim of this study was to investigate oregano and manuka essential oils (EOs) chemical compositions and evaluate their antibacterial activity (MIC, Minimum Inhibitory Concentration) against fourteen S. aureus wild strains. The second aim was to evaluate the antibacterial activities of oregano and manuka EOs mixed in different combination (FIC, Fractional Inhibitory Concentration) with an improved chequerboard technique...
January 2017: Microbiological Research
https://www.readbyqxmd.com/read/27992658/antimicrobial-activity-of-manuka-honey-against-antibiotic-resistant-strains-of-the-cell-wall-free-bacteria-ureaplasma-parvum-and-ureaplasma-urealyticum
#6
K L Hillitt, R E Jenkins, O B Spiller, M L Beeton
: The susceptibility of the cell wall-free bacterial pathogens Ureaplasma spp. to Manuka honey was examined. The minimum inhibitory concentration (MIC) of Manuka honey for four Ureaplasma urealyticum and four Ureaplasma parvum isolates was determined. Sensitivity to honey was also compared to clinical isolates with resistance to tetracycline, macrolide and fluoroquinolone antibiotics. Finally step-wise resistance training was utilized in an attempt to induce increased tolerance to honey...
December 19, 2016: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/27935259/manuka-honey-sinus-irrigation-for-the-treatment-of-chronic-rhinosinusitis-a-randomized-controlled-trial
#7
Victoria S Lee, Ian M Humphreys, Patricia L Purcell, Greg E Davis
BACKGROUND: Manuka honey (MH) has been shown in vitro to be effective against biofilm-producing bacteria. This study assessed the effectiveness of MH for patients with active chronic rhinosinusitis (CRS) and prior sinus surgery. METHODS: This prospective single-blinded (clinician only) randomized controlled trial recruited patients with active CRS and prior sinus surgery. Patients received either MH or saline (SAL) sinus irrigations twice daily for 30 days and were offered oral antibiotics and/or oral/topical steroids as indicated...
December 9, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27876081/in-vitro-activity-of-ten-essential-oils-against-sarcoptes-scabiei
#8
Fang Fang, Kerdalidec Candy, Elise Melloul, Charlotte Bernigaud, Ling Chai, Céline Darmon, Rémy Durand, Françoise Botterel, Olivier Chosidow, Arezki Izri, Weiyi Huang, Jacques Guillot
BACKGROUND: The development of alternative approaches in ectoparasite management is currently required. Essential oils have been demonstrated to exhibit fumigant and topical toxicity to a number of arthropods. The aim of the present study was to assess the potential efficacy of ten essential oils against Sarcoptes scabiei. METHODS: The major chemical components of the oils were identified by GC-MS analysis. Contact and fumigation bioassays were performed on Sarcoptes mites collected from experimentally infected pigs...
November 22, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27806565/fluorescent-pteridine-derivatives-as-new-markers-for-the-characterization-of-genuine-monofloral-new-zealand-manuka-leptospermum-scoparium-honey
#9
Nicole Beitlich, Tilo Lübken, Martin Kaiser, Lilit Ispiryan, Karl Speer
New Zealand manuka honey is well-known for its unique antibacterial activity. Due to its high price and limited availability, this honey is often subject to honey fraud. Two pteridine derivatives, 3,6,7-trimethyl-2,4(1H,3H)-pteridinedione and 6,7-dimethyl-2,4(1H,3H)-pteridinedione, have now been identified in New Zealand manuka honey. Their structures were elucidated by LC-QTOF-HRMS, NMR, and single-crystal X-ray diffraction after isolation via semipreparative HPLC. Their marker potential for authentic manuka honey was proved as both substances were detectable in neither the pollen-identical kanuka honey nor the nine other kinds of monofloral New Zealand honey analyzed (clover, forest, kamahi, pohutukawa, rata, rewarewa, tawari, thyme, and vipers bugloss)...
November 23, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27789370/application-of-doe-approach-in-the-development-of-mini-capsules-based-on-biopolymers-and-manuka-honey-polar-fraction-as-powder-formulation-for-the-treatment-of-skin-ulcers
#10
Marika Tenci, Silvia Rossi, Maria Cristina Bonferoni, Giuseppina Sandri, Irene Mentori, Cinzia Boselli, Antonia Icaro Cornaglia, Maria Daglia, Anna Marchese, Carla Caramella, Franca Ferrari
The aim of the present work was the development of a powder formulation for the delivery of manuka honey (MH) bioactive components in the treatment of chronic skin ulcers. In particular pectin (PEC)/chitosan glutamate (CS)/hyaluronic acid (HA) mini-capsules were obtained by inverse ionotropic gelation in presence of calcium chloride and subsequently freeze-dried. Optimization of unloaded (blank) formulation was performed using DoE approach. In a screening phase, the following three factors were investigated at two levels: CS (0...
January 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27787156/manuka-honey-helps-combat-urinary-tract-infections
#11
(no author information available yet)
Manuka honey curbs the growth of bacterial biofilms even at low dilutions, new research suggests.
October 26, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27785532/antibacterial-activity-and-chemical-characteristics-of-several-western-australian-honeys-compared-to-manuka-honey-and-pasture-honey
#12
Niloufar Roshan, Thomas Rippers, Cornelia Locher, Katherine A Hammer
The physicochemical parameters and antibacterial activity of 10 Western Australian (WA) and two comparator honeys were determined. Honeys showed a pH range of 4.0-4.7, colour range of 41.3-470.7 mAU, methylglyoxal levels ranging from 82.2 to 325.9 mg kg(-1) and hydrogen peroxide levels after 2 h of 22.7-295.5 µM. Antibacterial activity was assessed by the disc diffusion assay, phenol equivalence assay, determination of minimum inhibitory and bactericidal concentrations and a time-kill assay. Activity was shown for all honeys by one or more method, however, activity varied according to which assay was used...
October 26, 2016: Archives of Microbiology
https://www.readbyqxmd.com/read/27772925/inhibitory-effects-of-malaysian-tualang-honey-and-australian-new-zealand-manuka-honey-in-modulating-experimental-breast-cancers-induced-by-n-methyl-n-nitrosourea-mnu-a-comparative-study
#13
Nor Hayati Othman, Sarfraz Ahmed, Siti Amrah Sulaiman
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27751367/molecular-mechanisms-of-natural-honey-against-h-pylori-infection-via-suppression-of-nf-%C3%AE%C2%BAb-and-ap-1-activation-in-gastric-epithelial-cells
#14
Mohamed M M Abdel-Latif, Mekky M Abouzied
BACKGROUND AND AIMS: Natural honey has been used as a medicine since ancient times. Honey is widely known for its antibacterial properties against H. pylori; however, the mechanisms of its antibacterial activity are not fully known. The present study was performed to examine the molecular mechanisms by which natural honey can inhibit H. pylori infection in gastric epithelial cells. METHODS: Electrophoretic mobility shift assay was used to measure NF-κB- and AP-1-DNA binding activity...
July 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/27676607/the-bacterial-signature-of-leptospermum-scoparium-m%C3%A4-nuka-reveals-core-and-accessory-communities-with-bioactive-properties
#15
Wisnu Adi Wicaksono, E Eirian Jones, Jana Monk, Hayley J Ridgway
Leptospermum scoparium or mānuka is a New Zealand native medicinal plant that produces an essential oil with antimicrobial properties. This is the first study to investigate the structure and bioactivity of endophytic bacteria in mānuka by using a combination of cultivation-independent (DGGE) and dependent approaches. A total of 23 plants were sampled across three sites. Plants were considered either immature (3-8 years) or mature (>20 years). The endophyte community structure and richness was affected by plant tissue and bacterial communities became more stable and uniform as plant maturity increased...
2016: PloS One
https://www.readbyqxmd.com/read/27672214/diluted-honey-inhibits-biofilm-formation-potential-application-in-urinary-catheter-management
#16
Somadina Emineke, Alan J Cooper, Sarah Fouch, Brian R Birch, Bashir A Lwaleed
AIMS: Biofilms are ubiquitous and when mature have a complex structure of microcolonies in an extracellular polysaccharide and extracellular DNA matrix. Indwelling medical devices harbour biofilms which have been shown to cause infections and act as reservoirs for pathogens. Urinary catheters are often in place for considerable periods of time and are susceptible to both encrustation and biofilm formation. Strategies for minimising biofilm occurrence underpin an active research area in biomedicine...
February 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27664696/combination-of-1h-nmr-and-chemometrics-to-discriminate-manuka-honey-from-other-floral-honey-types-from-oceania
#17
Marc Spiteri, Karyne M Rogers, Eric Jamin, Freddy Thomas, Sophie Guyader, Michèle Lees, Douglas N Rutledge
Manuka honey is a product produced essentially in New Zealand, and has been widely recognised for its antibacterial properties and specific taste. In this study, 264 honeys from New Zealand and Australia were analysed using proton NMR spectroscopy coupled with chemometrics. Known manuka markers, methylglyoxal and dihydroxyacetone, have been characterised and quantified, together with a new NMR marker, identified as being leptosperin. Manuka honey profiling using 1H NMR is shown to be a possible alternative to chromatography with the added advantage that it can measure methylglyoxal (MGO), dihydroxyacetone (DHA) and leptosperin simultaneously...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27608515/manuka-honey-in-wound-management-greater-than-the-sum-of-its-parts
#18
REVIEW
R White
Few involved in wound care will have escaped the considerable interest which has been generated by the resurgence in honey. Equally, there will be many clinicians around the globe who are wondering why all the fuss, as they will have been using honey all along. However, even with the advent of 'medical-grade' honey, combined with considerable research into the numerous potential modes of action, there remains a lingering scepticism regarding the value of honey as a justified, modern intervention in wound care...
September 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27601610/in-vitro-activity-of-manuka-honey-and-polyhexamethylene-biguanide-on-filamentous-fungi-and-toxicity-to-human-cell-lines
#19
Joseph M Yabes, Brian K White, Clinton K Murray, Carlos J Sanchez, Katrin Mende, Miriam L Beckius, Wendy C Zera, Joseph C Wenke, Kevin S Akers
Soft-tissue invasive fungal infections are increasingly recognized as significant entities directly contributing to morbidity and mortality. They complicate clinical care, requiring aggressive surgical debridement and systemic antifungal therapy. To evaluate new topical approaches to therapy, we examined the antifungal activity and cytotoxicity of Manuka Honey (MH) and polyhexamethylene biguanide (PHMB). The activities of multiple concentrations of MH (40%, 60%, 80%) and PHMB (0.01%, 0.04%, 0.1%) against 13 clinical mould isolates were evaluated using a time-kill assay between 5 min and 24 h...
September 6, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27597636/a-split-body-randomized-blinded-study-to-evaluate-the-efficacy-of-a-topical-spray-composed-of-essential-oils-and-essential-fatty-acids-from-plant-extracts-with-antimicrobial-properties
#20
Emmanuel Bensignor, Lionel Fabriès, Lucie Bailleux
BACKGROUND: Bacterial pyoderma is a frequent presentation in dogs. Despite the widespread availability of effective systemic and topical antimicrobial products, good clinical practice currently recommends avoidance of long-term use to mitigate the development of bacterial resistance. HYPOTHESIS/OBJECTIVES: To evaluate the speed of resolution of clinical signs of bacterial pyoderma in dogs treated with a systemic antimicrobial agent with or without the use of an adjunctive spray with antimicrobial properties...
December 2016: Veterinary Dermatology
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