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A-G E Ausseil, J R Dymond, L Newstrom
Honey bees require nectar and pollen from flowers: nectar for energy and pollen for growth. The demand for nectar and pollen varies during the year, with more pollen needed in spring for colony population growth, and more nectar needed in summer to sustain the maximum colony size and collect surplus nectar stores for winter. Sufficient bee forage is therefore necessary to ensure a healthy bee colony. Land-use changes can reduce the availability of floral resources suitable for bees, thereby increasing the susceptibility of bees to other stressors such as disease and pesticides...
March 12, 2018: Ecological Applications: a Publication of the Ecological Society of America
Jianling Deng, Rui Liu, Qun Lu, Peiyan Hao, Anqi Xu, Jiuliang Zhang, Jun Tan
The biochemical properties of buckwheat honey, including contents of sugars, proteins, total phenols, methylglyoxal (MGO), minerals and phenolic compounds, were determined in comparison with those of manuka honey. Buckwheat honey has higher contents of sugars, proteins and total phenols but a lower content of MGO than manuka honey. Buckwheat honey contains abundant minerals involved in a number of vital functions of the human body as does manuka honey, and has even higher contents of Fe, Mn and Zn. In buckwheat honey, p-hydroxybenzoic acid, chlorogenic acid and p-coumaric acid are the dominant phenolic compounds...
June 30, 2018: Food Chemistry
Ainau R Idris, Seniyat L Afegbua
Background: Multidrug resistance and recent technological advances have renewed interest in natural product drug discovery from ancient remedies such as Allium sativum (garlic) and honey. This study assessed antibacterial activity of aqueous garlic extract (AGE) and Manuka honey on extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. Methods: Thirty clinical isolates of E. coli were collected and screened for ESBL production by double-disc synergy test...
January 24, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
Abdul Hannan, Asma Ejaz Bajwa, Saira Riaz, Usman Arshad, Sidrah Saleem, Usama Ijaz Bajwa
Biofilm is a complex community of single or different types of microorganisms (bacteria, viruses, fungi, protozoa) attached to a surface and stick to each other through production of extracellular matrix. Salmonella typhi forms biofilm on cholesterol gallstones resulting in carrier state. Once formed, biofilm is difficult to treat. To date cholecystectomy is the only cure for this condition. Manuka honey is known to have tremendous antibiofilm activity against various organisms. S. typhi biofilm was grown in vitro on clinical samples of human cholesterol gallstones by Gallstone tube assay method for 12 days...
January 2018: Pakistan Journal of Pharmaceutical Sciences
Sushil Anand, Edwin Pang, George Livanos, Nitin Mantri
The antioxidant and antimicrobial components of honey vary based on sourced of nectar. Medicinal plants with the therapeutic value have potential to produce honey with greater bioactivity. The aim of the present study was to characterize the physico-chemical and antioxidant capacities of Agastache honey produced from Agastache rugosa and compare them with other popular commercial honeys sold in Australia. The total phenolics, total flavonoids, moisture content, colour, pH, protein content and antioxidant capacity were evaluated for Agastache, Manuka, Jelly bush, Tea tree, Super manuka and Jarrah honeys...
January 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Michael J Clearwater, Maria Revell, Stevie Noe, Merilyn Manley-Harris
Background and Aims: Floral nectar can be variable in composition, influencing pollinator behaviour and the composition of honey derived from it. The non-peroxide antibacterial activity of mānuka (Leptospermum scoparium, Myrtaceae) honey results from the chemical conversion of the triose sugar dihydroxyacetone (DHA), after DHA accumulates for an unknown reason in the nectar. This study examined variation in nectar DHA, glucose, fructose and sucrose content with floral stage of development, between mānuka genotypes with differing flower morphology, and in response to water stress...
January 2, 2018: Annals of Botany
Barbara Turchi, Simone Mancini, Luisa Pistelli, Basma Najar, Filippo Fratini
Fourteen Staphylococcus aureus wild strains were stressed with sub-inhibitory concentration of five essential oils: Leptospermum scoparium (manuka), Origanum majorana (marjoram), Origanum vulgare (oregano), Satureja montana (winter savoury) and Thymus vulgaris (thyme). Antibiotics susceptibility profiles of the strains were determined by agar disk diffusion method before and after EOs treatment. The following antibiotics were employed: amoxicillin-clavulanic acid, amikacin, ampicillin, amoxicillin, aztreonam, ceftazidime, cephalothin, ciprofloxacin, colistin, cefotaxime, doxycycline, enrofloxacin, erythromycin, gentamicin, cephalexin, neomycin, piperacillin, rifampin, streptomycin, trimethoprim-sulphamethoxazole, tetracycline and tobramycin...
December 22, 2017: Natural Product Research
Simone Ronsisvalle, Edmondo Lissandrello, Virginia Fuochi, Giulio Petronio Petronio, Claudia Straquadanio, Lucia Crascì, Annamaria Panico, Marcella Milito, Anna Maria Cova, Gianna Tempera, Pio Maria Furneri
The aim of this study was the evaluation of antibacterial and antioxidant properties of Monofloral Etna Castanea sativa Miller honeys. Escherichia coli ATCC 25,922, Pseudomonas aeruginosa ATCC 27,853, Enterococcus faecalis ATCC 29,211 and Staphylococcus aureus ATCC 29,213 were investigated for their susceptibilities to two different honeys. Antioxidant activity was evaluated by ORAC, NO scavenger assays, FRAP and DPPH. Antioxidant activity and antibacterial properties were compared with chestnut honeys from different geographical areas and with Manuka honey...
December 13, 2017: Natural Product Research
Muhammad Usman Qamar, Sidrah Saleem, Mark Alexander Toleman, Muhammad Saqalein, Muhammad Waseem, Muhammad Atif Nisar, Mohsin Khurshid, Zeeshan Taj, Shah Jahan
AIM: To determine the therapeutic potential of Manuka honey against New Delhi metallo-β-lactamase-1-producing Klebsiella pneumoniae ST11 in vitro and in vivo. MATERIALS & METHODS: Carbapenamases and metallo-β-lactamases-producing K. pneumoniae ST11 isolated from blood culture was confirmed by VITEK-2® system, matrix-assisted laser desorption ionization-time of flight and multilocus sequence typing, followed by determination of minimum inhibitory concentration (μg/ml) using VITEK-2 system...
January 2018: Future Microbiology
Jeanine Harrison
Many mainstream medications were derived from plants and originally utilized in patient management well prior to the extensive research and testing processes of current pharmaceutical standards. The evolution of therapeutic management within the pharmaceutical and skin care industry often uses synthetic processing of products with less of a focus on the natural ingredients from which they were originally derived. However, more recently there has been a shift in pharmacological management to include the therapeutic use of more holistic medicines and practices and thus a broadening of the uses of nontraditional medical treatment options...
October 2017: Plastic Surgical Nursing
Weijia Zheng, Jin-A Park, A M Abd El-Aty, Seong-Kwan Kim, Sang-Hyun Cho, Jeong-Min Choi, Hee Yi, Soo-Min Cho, Amer Ramadan, Ji Hoon Jeong, Jae-Han Shim, Ho-Chul Shin
Over the past few decades, honey products have been polluted by different contaminants, such as pesticides, which are widely applied in agriculture. In this work, a modified EN - quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction method was developed for the simultaneous quantification of pesticide residues, including cymiazole, fipronil, coumaphos, fluvalinate, amitraz, and its metabolite 2,4-dimethylaniline (2,4-DMA), in four types of honey (acacia, wild, chestnut, and manuka) and royal jelly...
November 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Harriet Whiley, Sharyn Gaskin, Tiffany Schroder, Kirstin Ross
Concerns regarding indoor air quality, particularly the presence of fungi and moulds, are increasing. The potential for essential oils to reduce, control or remove fungi, is gaining interest as they are seen as a "natural" alternative to synthetic chemical fungicides. This review examines published research on essential oils as a method of fungal control in indoor environments. It was difficult to compare the relative performances of essential oils due to differences in research methods and reporting languages...
October 27, 2017: Reviews on Environmental Health
Chongyu Shen, Siyan Guo, Tao Ding, Yun Liu, Lei Chen, Xiaoqing Fei, Rui Zhang, Bin Wu, Weijian Shen, Lei Chen, Feng Zhang, Feng Feng, Xiaojun Deng, Xionghai Yi, Gongjun Yang, Guoqiang Chen
A method for the determination of characteristic compound 3,5-dimethoxybenzoate-4-diglucoside (leptosperin) in manuka honey was developed by automatic on-line solid phase extraction-liquid chromatography-high resolution mass spectrometry (SPE-LC-HRMS). The samples were separated on a Dikma Diamonsil Plus C18 column (150 mm×4.6 mm, 5 μm) using the mobile phases of 0.1% (v/v) formic acid aqueous solution and acetonitrile with gradient elution. The compound was detected with negative electrospray ionization (ESI(-)) in Target-MS(2) mode...
October 8, 2017: Se Pu, Chinese Journal of Chromatography
Daniel Wong, Julie M Albietz, Huan Tran, Cimonette Du Toit, Anita Hui Li, Tina Yun, Jee Han, Katrina L Schmid
AIM: Contact lens induced dry eye affects approximately 50% of contact lens wearers. The aim was to assess the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia) on dry eye in contact lens wearers. The safety of the honey eye drops in contact lens wear and contact lens wearers' compliance were also evaluated. DESIGN: Prospective, randomised, cross over study, examiner masked, pilot treatment trial. METHODS: Twenty-four participants aged 20 to 55 years with contact lens related dry eye were recruited and randomised to two treatment groups; 20 completed the study...
October 9, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
Ephantus J Muturi, Jose L Ramirez, Kenneth M Doll, Michael J Bowman
Essential oils are potential alternatives to synthetic insecticides because they have low mammalian toxicity, degrade rapidly in the environment, and possess complex mixtures of bioactive constituents with multi-modal activity against the target insect populations. Twenty-one essential oils were initially screened for their toxicity against Aedes aegypti (L.) larvae and three out of the seven most toxic essential oils (Manuka, oregano, and clove bud essential oils) were examined for their chemical composition and combined toxicity against Ae...
November 7, 2017: Journal of Medical Entomology
Katherine R Hixon, Tracy Lu, Marissa N Carletta, Sarah H McBride-Gagyi, Blythe E Janowiak, Scott A Sell
Previous studies have identified honey as an agent in bacterial inhibition and a mediator in lowering the pH at the wound site. Manuka honey (MH), indigenous to New Zealand, contains a Unique Manuka Factor that provides an additional antibacterial agent. While there are many potential benefits to incorporating MH into wounds, there is currently no ideal way to deliver the material to the site of injury. Cryogels are a type of scaffold that possess high porosity, mechanical stability, and a sponge-like consistency...
September 27, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Huong Thi Lan Nguyen, Naksit Panyoyai, Vilia Darma Paramita, Nitin Mantri, Stefan Kasapis
The present work investigated the physicochemical and structural properties of Tulsi, Alfalfa and two varieties of Manuka honey derived from medicinal plants. Chemical analysis yielded data on the content of reducing sugars (glucose and fructose) that dominate the honey matrix, and of the minor constituents of protein, phenols and flavonoids. Standard chemical assays were used to develop a database of water content, electrical conductivity, pH, ash content, visual appearance and colour intensity. Physicochemical characteristics were related to structural behaviour of the four honey types, as recorded by small-deformation dynamic oscillation in shear, micro- and modulated differential scanning calorimetry, wide angle X-ray diffraction and infrared spectroscopy...
February 15, 2018: Food Chemistry
Kamal Niaz, Faheem Maqbool, Haji Bahadar, Mohammad Abdollahi
BACKGROUND: Honey is known for its therapeutic properties from ancient civilizations. Recently, the mechanism of action of Manuka honey in wound healing, epithelial regeneration, and ulcer treatments has been revealed. OBJECTIVE: In the current review, the health perspectives of honey, its chemical composition with special reference to flavonoids, polyphenol, and other bioactive trace compounds used in tissue regeneration have been discussed in detail. METHODS: We undertook a structured search using wide spectrum sources like Google Scholar, PubMed, and Scopus...
2017: Current Drug Metabolism
Denis Watson, Stephen Bergquist, Julie Nicholson, David H Norrie
OBJECTIVE: While Manuka honey in vitro is strongly antimicrobial, there have been, to the best of the authors' knowledge, no studies showing that dressings impregnated with Manuka honey can kill organisms in the dressing itself. MATERIALS AND METHODS: The investigators used the American Association of Textile Chemists and Colorists' 100 test methodology to compare honey-impregnated dressings with control dressings (without honey) on the ability to kill common wound pathogens...
July 26, 2017: Wounds: a Compendium of Clinical Research and Practice
Priyanka Aryappalli, Sarah S Al-Qubaisi, Samir Attoub, Junu A George, Kholoud Arafat, Khalil B Ramadi, Yassir A Mohamed, Mezoon M Al-Dhaheri, Ashraf Al-Sbiei, Maria J Fernandez-Cabezudo, Basel K Al-Ramadi
There is renewed interest in the potential use of natural compounds in cancer therapy. Previously, we demonstrated the anti-tumor properties of manuka honey (MH) against several cancers. However, the underlying mechanism and molecular targets of this activity remain unknown. For this study, the early targets of MH and its modulatory effects on proliferation, invasiveness, and angiogenic potential were investigated using two human breast cancer cell lines, the triple-negative MDA-MB-231 cells and estrogen receptor-positive MCF-7 cells, and the non-neoplastic breast epithelial MCF-10A cell line...
2017: Frontiers in Oncology
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