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Keywords Skin and soft tissue infection...

Skin and soft tissue infection treatment

https://read.qxmd.com/read/38438813/-bacterial-endogenous-endophthalmitis-spectrum-of-pathogens-and-drug-therapy
#21
REVIEW
Thomas Ness
Endogenous endophthalmitis represents an ophthalmological emergency requiring immediate diagnostics and treatment. Pathogens should be detected using appropriate methods, such as the Freiburg endophthalmitis set. In bacterial endophthalmitis both Gram-positive and Gram-negative bacteria can be detected. Frequent underlying sources include endocarditis, gastrointestinal or urogenital surgery, indwelling venous catheters, liver abscesses, skin or soft tissue infections, meningitis or less commonly, intravenous drug abuse...
March 4, 2024: Ophthalmologie
https://read.qxmd.com/read/38427289/dalbavancin-sequential-therapy-for-gram-positive-bloodstream-infection-a-multicenter-observational-study
#22
JOURNAL ARTICLE
Nicholas Rebold, Sara Alosaimy, Jeffrey C Pearson, Brandon Dionne, Ahmad Taqi, Abdalhamid Lagnf, Kristen Lucas, Mark Biagi, Nicholas Lombardo, Joshua Eudy, Daniel T Anderson, Monica V Mahoney, Wesley D Kufel, Joseph A D'Antonio, Bruce M Jones, Jeremy J Frens, Tyler Baumeister, Matthew Geriak, George Sakoulas, Dimitrios Farmakiotis, Dino Delaportas, Jeremy Larew, Michael P Veve, Michael J Rybak
INTRODUCTION: Long-acting lipoglycopeptides such as dalbavancin may have utility in patients with Gram-positive bloodstream infections (BSI), particularly in those with barriers to discharge or who require prolonged parenteral antibiotic courses. A retrospective cohort study was performed to provide further multicenter real-world evidence on dalbavancin use as a sequential therapy for Gram-positive BSI. METHODS: One hundred fifteen patients received dalbavancin with Gram-positive BSI, defined as any positive blood culture or diagnosed with infective endocarditis, from 13 centers geographically spread across the United States between July 2015 and July 2021...
March 1, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38415568/necrotising-soft-tissue-infections
#23
JOURNAL ARTICLE
Ingunn Margareetta Gundersen, Trond Bruun, Stian Kreken Almeland, Dag Harald Skutlaberg, Torbjørn Nedrebø, Eivind Rath, Oddvar Oppegaard, Anne Berit Guttormsen, Anna Norrby-Teglund, Knut Anders Mosevoll, Steinar Skrede
Necrotising soft tissue infections can affect the skin, subcutaneous tissue, superficial fascia, deep fascia and musculature. The infections are severe, they spread quickly and can result in extensive tissue loss. Although rare, morbidity and mortality rates are high. Early clinical identification is crucial for the outcome, and rapid infection control through surgery and targeted antibiotic treatment is needed to save lives. Few prospective clinical trials have been conducted for the treatment of this type of infection...
February 27, 2024: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://read.qxmd.com/read/38414772/extensively-drug-resistant-pseudomonas-aeruginosa-clinical-features-and-treatment-with-ceftazidime-avibactam-and-ceftolozane-tazobactam-in-a-tertiary-care-university-hospital-center-in-portugal-a-cross-sectional-and-retrospective-observational-study
#24
JOURNAL ARTICLE
Diogo Mendes Pedro, Sérgio Eduardo Paulo, Carla Mimoso Santos, Ana Bruschy Fonseca, José Melo Cristino, Álvaro Ayres Pereira, Cátia Caneiras
INTRODUCTION: Extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) is a growing concern due to its increasing incidence, limited therapeutic options, limited data on the optimal treatment, and high mortality rates. The study aimed to characterize the population, the outcome and the microbiological characteristics of XDR-PA identified in a Portuguese university hospital center. METHODS: All XDR-PA isolates between January 2019 and December 2021 were identified...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38410683/reverse-posterior-interosseous-artery-flap-for-human-bite-injury-to-the-hand
#25
Yusuke Hattori, Yohei Kawaguchi, Yuji Joyo, Hideki Okamoto, Hideki Murakami, Yuko Waguri-Nagaya
Bite injuries frequently occur on human hands. Human bite injuries to the hand may lead to an infection because of limited soft tissue protection and wound contamination. However, no studies have reported severe bite injuries on hands treated by flaps. We report a case of an 80-year-old woman diagnosed with a major neurocognitive disorder. The patient accidentally had a self-bite injury accompanied with an open metacarpal fracture. Debridement and fixation of the first metacarpal fracture were performed. Afterward, skin necrosis occurred gradually on the dorsum of the hand...
2024: Case Reports in Orthopedics
https://read.qxmd.com/read/38394109/deciphering-the-structure-of-a-multi-drug-resistant-acinetobacter-baumannii-short-chain-dehydrogenase-reductase
#26
JOURNAL ARTICLE
Mahdi Abedinzadeh Shahri, Paniz Shirmast, Seyed Mohammad Ghafoori, Jade Kenneth Forwood
The rapidly increasing threat of multi-drug-resistant Acinetobacter baumannii infections globally, encompassing a range of clinical manifestations from skin and soft tissue infections to life-threatening conditions like meningitis and pneumonia, underscores an urgent need for novel therapeutic strategies. These infections, prevalent in both hospital and community settings, present a formidable challenge to the healthcare system due to the bacterium's widespread nature and dwindling effective treatment options...
2024: PloS One
https://read.qxmd.com/read/38394042/a-nanocomposite-dynamic-covalent-cross-linked-hydrogel-loaded-with-fusidic-acid-for-treating-antibiotic-resistant-infected-wounds
#27
JOURNAL ARTICLE
Samaneh Toufanian, Jody Mohammed, Erica Winterhelt, Andrew Lofts, Ridhdhi Dave, Brian K Coombes, Todd Hoare
Methicillin-resistant Staphylococcus aureus (MRSA) is associated with high levels of morbidity and is considered a difficult-to-treat infection, often requiring nonstandard treatment regimens and antibiotics. Since over 40% of the emerging antibiotic compounds have insufficient solubility that limits their bioavailability and thus efficacy through oral or intravenous administration, it is crucial that alternative drug delivery products be developed for wound care applications. Existing effective treatments for soft tissue MRSA infections, such as fusidic acid (FA), which is typically administered orally, could also benefit from alternative routes of administration to improve local efficacy and bioavailability while reducing the required therapeutic dose...
February 23, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38391573/catastrophic-streptococcus-pyogenes-disease-a-personalized-approach-based-on-phenotypes-and-treatable-traits
#28
JOURNAL ARTICLE
Juan Carlos Ruiz-Rodríguez, Luis Chiscano-Camón, Carolina Maldonado, Adolf Ruiz-Sanmartin, Laura Martin, Ivan Bajaña, Juliana Bastidas, Rocio Lopez-Martinez, Clara Franco-Jarava, Juan José González-López, Vicent Ribas, Nieves Larrosa, Jordi Riera, Xavier Nuvials-Casals, Ricard Ferrer
Streptococcal toxic shock syndrome (STTS) is a critical medical emergency marked by high morbidity and mortality, necessitating swift awareness, targeted treatment, and early source control due to its rapid symptom manifestation. This report focuses on a cohort of 13 patients admitted to Vall d'Hebron University Hospital Intensive Care Unit, Barcelona, from November 2022 to March 2023, exhibiting invasive Streptococcus pyogenes infections and meeting institutional sepsis code activation criteria. The primary infections were community-acquired pneumonia (61...
February 15, 2024: Antibiotics
https://read.qxmd.com/read/38389845/metal-nanoparticle-hybrid-hydrogels-the-state-of-the-art-of-combining-hard-and-soft-materials-to-promote-wound-healing
#29
REVIEW
Yuxiang Wang, Mengya Zhang, Zhenzhen Yan, Shizhao Ji, Shichu Xiao, Jie Gao
Wounds represent a grave affliction that profoundly impacts human well-being. Establishing barriers, preventing infections, and providing a conducive microenvironment constitute the crux of wound therapy. Hydrogel, a polymer with an intricate three-dimensional lattice, serves as a potent tool in erecting physical barriers and nurturing an environment conducive to wound healing. This enables effective control over exudation, hemostasis, accelerated wound closure, and diminished scar formation. As a result, hydrogels have gained extensive traction in the realm of wound treatment...
2024: Theranostics
https://read.qxmd.com/read/38384696/influenza-vaccine-related-periostitis-a-case-report-of-a-rare-complication
#30
Kaitlyn R Julian, Kevin Sweetwood, Daria Motamedi
As social distancing guidelines continue to diminish across the country, viral pathogens that were once absent during the COVID-19 pandemic, such as influenza and RSV, have once again become prominent. Although serious side effects of vaccinations are rare, local complications of bursitis and skin and soft tissue infections are well-documented in the literature. We present a case of 1 such rare side effect: influenza vaccine related periostitis. A 39-year-old male patient presented with left shoulder pain which developed 2 days after an influenza vaccination administered to the left deltoid...
May 2024: Radiology Case Reports
https://read.qxmd.com/read/38374030/efficacy-and-safety-of-omadacycline-for-treating-complicated-skin-and-soft-tissue-infections-a-meta-analysis-of-randomized-controlled-trials
#31
JOURNAL ARTICLE
Wenxin Liang, Hong Yin, Huiling Chen, Juan Xu, Yun Cai
OBJECTIVE: In the present study, we aimed to compare the clinical efficacy and safety of omadacycline (OMC) with its comparators for the treatment of complicated skin and soft tissue infections (cSSTIs) in adult patients. METHODS: Randomized controlled trials (RCTs) evaluating OMC for cSSTIs were searched in databases of PubMed, Embase, Cochrane, Web of Science, and Clinical Trial, up to July 2022. The primary outcomes were clinical efficacy and microbiological response, with secondary outcome was safety...
February 19, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38372844/antimicrobial-photodynamic-therapy-with-brazilian-green-propolis-controls-intradermal-infection-induced-by-methicillin-resistant-staphylococcus-aureus-and-modulates-the-inflammatory-response-in-a-murine-model
#32
JOURNAL ARTICLE
Israel Souza Ribeiro, Igor Pereira Ribeiro Muniz, Maria Poliana Leite Galantini, Caroline Vieira Gonçalves, Paulo Henrique Bispo Lima, Nathalia Rosa Silva, Samara Lopes de Oliveira, Marlon Silva Nunes, Amanda Kelle Santos Novaes, Maria Eduarda Santos de Oliveira, Dirceu Joaquim Costa, Juliano Geraldo Amaral, Robson Amaro Augusto da Silva
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of skin and soft tissue infections worldwide. This microorganism has a wide range of antibiotics resistance, a fact that has made the treatment of infections caused by MRSA difficult. In this sense, antimicrobial photodynamic therapy (aPDT) with natural products has emerged as a good alternative in combating infections caused by antibiotic-resistant microorganisms. The objective of the present study was to evaluate the effects of aPDT with Brazilian green propolis against intradermal MRSA infection in a murine model...
February 19, 2024: Photochemical & Photobiological Sciences
https://read.qxmd.com/read/38367805/epidemiology-clinical-profile-and-outcomes-of-csf-diversion-catheter-related-infections-prospective-cohort-study-results-from-a-single-quaternary-neurosurgery-referral-centre
#33
JOURNAL ARTICLE
Dinoop Korol Ponnambath, Ganesh Divakar, Jincy Mamachan, Shiny Biju, Kavita Raja, Mathew Abraham
BACKGROUND: Device-associated CNS infections is a major subgroup of healthcare associated CNS infections. Healthcare-associated ventriculitis or meningitis differs considerably from community-acquired meningitis in its epidemiology, pathogenesis, clinical presentation and management. OBJECTIVES: This study aimed to identify the infection rates, the associated risk factors, and outcomes of these life-threatening infections. METHODS: This was a 2-year single center prospective cohort study...
February 15, 2024: Indian Journal of Medical Microbiology
https://read.qxmd.com/read/38363945/recurrent-hematuria-involving-urinary-system-with-klippel-trenaunay-syndrome-a-case-report
#34
JOURNAL ARTICLE
Feng Lin, Kewei Yang, Jiadong Xu, Gang Wang, Lixia Yang, Jinrong Huang, Dan Li
RATIONALE: Klippel-Trenaunay syndrome (KTS) is a rare congenital venous malformation, it had been found to be caused by mutations of the phosphatidylinositol 4, 5-diphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene. Currently KTS is defined as a triad of skin wine pigmented spots, varicose veins and malformations of the lower extremities, and hypertrophy of bone and soft tissue, involving urinary system up to 6% to 30%. When the urinary system is involved, KTS is often presented as painless massive gross hematuria...
February 16, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38363930/lemierre-like-syndrome-after-soft-tissue-infection-due-to-methicillin-resistant-staphylococcus-aureus-a-case-report-and-literature-review
#35
REVIEW
Xosse Carreras, Andrea S Salcedo, Linda Ponce-Rosas, Jose A Gonzales-Zamora, Nelson Diaz, Jorge Alave
RATIONALE: Lemierre-like syndrome (LLS) is characterized by bacteremia, septic thrombophlebitis of the internal jugular vein, and metastatic abscesses. In contrast to classic Lemierre syndrome, sources of infection are not related to oropharyngeal infections, as are frequent soft tissue infections. In recent years, Staphylococcus aureus has been identified as an emergent pathogen that causes this syndrome. The mortality rate of LLS caused by this pathogen is approximately 16%. Timely diagnosis, antibiotic treatment, and infection control are the cornerstones to treat LLS...
February 16, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38361042/-skin-abscess-caused-by-actinomyces-radingae
#36
JOURNAL ARTICLE
Miodrag Davidovic, Miriam Eva Ecker, Anne Kathrin Lößlein, Kilian Eyerich, Christoph Mathis Schempp
We report a 77-year-old man with a skin abscess caused by Actinomyces radingae. Targeted antibiotic therapy with amoxicillin/clavulanic acid for 6 weeks resulted in clearing of the infection. A. radingae is a rare pathogenic agent of skin and soft tissue infections. As with other Actinomyces infections, the early identification of the pathogen and specific antibiotic therapy is crucial for successful resolution of the infection because of the chronic course and the long treatment time needed...
February 15, 2024: Dermatologie (Heidelb)
https://read.qxmd.com/read/38359743/oral-and-oropharyngeal-mucosal-lesions-clinical-epidemiological-study-of-patients-attended-at-a-reference-center-for-infectious-diseases
#37
JOURNAL ARTICLE
Clarissa Souza Mota Reis, João Gustavo Corrêa Reis, Fátima Conceição-Silva, Cláudia Maria Valete
OBJECTIVE: To determine the prevalence, epidemiological profile, and clinical characteristics of Oral or Oropharyngeal Mucosal Lesions (OOPML) in patients attended at the Otorhinolaryngology Service of the Evandro Chagas National Institute of Infectious Diseases (INI-FIOCRUZ) from 2005 to 2017. METHODS: Statistical analysis of descriptive data from medical records (gender, age, education level, skin color, origin, smoking, alcoholism, HIV co-infection, time of disease evolution, first symptom, and OOPML location) was performed...
February 1, 2024: Brazilian Journal of Otorhinolaryngology
https://read.qxmd.com/read/38353284/full-face-and-neck-resurfacing-with-a-novel-ablative-fractional-2910%C3%A2-nm-erbium-doped-fluoride-glass-fiber-laser-for-advanced-photoaging
#38
JOURNAL ARTICLE
Taryn N Murray, Jamie K Hu, Paul M Friedman
OBJECTIVES: Ablative fractional lasers have long been considered the gold standard for facial resurfacing for advanced photoaging. These lasers offer an improved safety profile compared to traditional ablative lasers but typically require more treatment sessions given their fractional approach. In this study, we evaluate a new novel 2910 nm erbium-doped fluoride glass fiber laser (2910 nm fiber laser) (UltraClear; Acclaro Medical) for full-face and neck resurfacing for the treatment of advanced photoaging...
February 14, 2024: Lasers in Surgery and Medicine
https://read.qxmd.com/read/38349162/sensitizing-methicillin-resistant-staphylococcus-aureus-mrsa-to-cefuroxime-the-synergic-effect-of-bicarbonate-and-the-wall-teichoic-acid-inhibitor-ticlopidine
#39
JOURNAL ARTICLE
Selvi C Ersoy, Richard A Proctor, Warren E Rose, Wessam Abdelhady, Sook-Ha Fan, Sabrina L Madrigal, Ahmed M Elsayed, Henry F Chambers, Rita G Sobral, Arnold S Bayer
Methicillin-resistant Staphylococcus aureus (MRSA) strains are a major challenge for clinicians due, in part, to their resistance to most β-lactams, the first-line treatment for methicillin-susceptible S. aureus . A phenotype termed "NaHCO3 -responsiveness" has been identified, wherein many clinical MRSA isolates are rendered susceptible to standard-of-care β-lactams in the presence of physiologically relevant concentrations of NaHCO3 , in vitro and ex vivo ; moreover, such "NaHCO3 -responsive" isolates can be effectively cleared by β-lactams from target tissues in experimental infective endocarditis (IE)...
February 13, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38344579/prolonged-atypical-and-fulminant-mpox-in-a-hiv-hbv-coinfected-patient-a-case-report
#40
Felipe de Jesus Perez-Hernandez, Victor Aaron Alvarez-Sanchez, Darwin Torres-Erazo, Monica Ceballos-Perez, Carlos David Franco-Gonzalez
Mpox (monkeypox) is a zoonotic disease that has been endemic in African countries for decades, with a recent global outbreak in countries around the world. A 39-year-old male with human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfection and poor adherence to antiretroviral treatment, who was severely immunocompromised and had a concurrent diagnosis of Mpox, presented to our hospital with disseminated skin lesions (over 350 lesions), perianal ulcers, odynophagia, oral intolerance, diarrhea, and soft-tissue bacterial superinfection of the lower extremities...
January 2024: Curēus
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