Nathan Bénac, G Ezequiel Saraceno, Corey Butler, Nahoko Kuga, Yuya Nishimura, Taiki Yokoi, Ping Su, Takuya Sasaki, Mar Petit-Pedrol, Rémi Galland, Vincent Studer, Fang Liu, Yuji Ikegaya, Jean-Baptiste Sibarita, Laurent Groc
Direct interactions between receptors at the neuronal surface have long been proposed to tune signaling cascades and neuronal communication in health and disease. Yet, the lack of direct investigation methods to measure, in live neurons, the interaction between different membrane receptors at the single molecule level has raised unanswered questions on the biophysical properties and biological roles of such receptor interactome. Using a multidimensional spectral single molecule-localization microscopy (MS-SMLM) approach, we monitored the interaction between two membrane receptors, i...
January 2, 2024: Nature Communications