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treatment of membranous nephropathy

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https://www.readbyqxmd.com/read/29792170/liddle-s-like-syndrome-associated-with-nephrotic-syndrome-secondary-to-membranous-nephropathy-the-first-case-report
#1
Eriko Yamaguchi, Kazuhiro Yoshikawa, Izaya Nakaya, Karen Kato, Yoshikazu Miyasato, Terumasa Nakagawa, Yutaka Kakizoe, Masashi Mukoyama, Jun Soma
BACKGROUND: Liddle's syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome present with early onset of hypertension, hypokalemia, metabolic alkalosis, hyporeninemia and hypoaldosteronism, and a potassium-sparing diuretics (triamterene or amiloride) can drastically improves the disease condition. Although elderly patients having these characteristics were considered to have Liddle's syndrome or Liddle's-like syndrome, no previous report has indicated that Liddle's-like syndrome could be caused by nephrotic syndrome of primary glomerular disease, which is characterized by urinary excretion of > 3 g of protein/day plus edema and hypoalbuminemia, or has explained how the activity function of ENaC could be affected in the setting of high proteinuria...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29792169/use-of-synthetic-adrenocorticotropic-hormone-in-patients-with-iga-nephropathy
#2
Bhanu Prasad, Shelley Giebel, Michelle C E McCarron, Nelson Leung
BACKGROUND: Synthetic adrenocorticotropic hormone (ACTH) has been demonstrated to be effective in patients with membranous nephropathy, minimal change disease and some histological subtypes of focal segmental glomerulosclerosis. Its clinical impact in patients with IgA nephropathy is currently unclear. CASE PRESENTATION: In this report, we describe the clinical use of ACTH in patients with IgA nephropathy. Three female patients (24-44 years) with overt proteinuria received intramuscular (IM) ACTH for varying time periods (8-14 months)...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29781318/hypochlorite-modified-albumins-promote-cell-death-in-the-tubule-interstitium-in-rats-via-mitochondrial-damage-in-obstructive-nephropathy-and-the-protective-effects-of-antioxidant-peptides
#3
Zong-Rui Liu, Si-Qi Chen, Yao-Wei Zou, Xiao-Yu Wu, Hong-Ying Li, Xiao-Qiao Wang, Yue Shi, Hong-Xin Niu
A major feature of the injury sustained by the kidney during obstructive nephropathy is a profound induction of apoptosis in the tubular epithelium. In this study, we explored the central roles of mitochondria and the mechanism of the protective effect of the mitochondrial targeted peptides in tubular cell apoptosis and interstitial fibrosis during obstructive nephropathy. Unilateral ureter obstruction (UUO) was performed on rats, and the animals were randomly assigned to intravenous treatment with normal saline, rat serum albumin (RSA), or HOCl-rat serum albumin (HOCl-RSA) in the presence or absence of SS-31...
May 2018: Free Radical Research
https://www.readbyqxmd.com/read/29769410/human-anti-thrombospondin-type-1-domain-containing-7a-antibodies-induce-membranous-nephropathy-through-activation-of-lectin-complement-pathway
#4
Zheng Wang, Lu Wen, Yanna Dou, Zhanzheng Zhao
To investigate whether the human anti-thrombospondin type 1 domain-containing 7A (THSD7A) antibody-induced membranous nephropathy is mediated by activating lectin complement pathway. Automatic biochemical apparatus was used to assess renal function of mice. The serum levels of anti-THSD7A antibodies and complement were tested by using Enzyme-linked immunosorbent assay (ELISA). The expression level of THSD7A and Mannose-Binding Lectin (MBL) in clinical tissue, and the histological features of MN in mice were examined by immunochemical methods...
May 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29766466/concurrent-isolated-igg2-positive-membranous-nephropathy-and-malignant-b-cell-lymphoma
#5
Satoshi Shimada, Takashi Nakamichi, Gen Yamada, Kaori Narumi, Hajime Usubuchi, Tae Yamamoto, Satoshi Ichikawa, Noriko Fukuhara, Mariko Miyazaki, Hideo Harigae, Hiroshi Sato, Sadayoshi Ito
A recent systematic review showed that hematological malignancy is often complicated by membranous nephropathy (MN). Histologically, the deposition of IgG subclasses other than IgG4 may imply secondary MN, such as malignancy-associated MN (M-MN). We describe a very rare case of concurrent isolated IgG2-positive MN and B-cell lymphoma. An 83-year-old woman was hospitalized at our institute for facial and lower extremity edema persisting for 2 months. Laboratory tests showed urinary protein level of 10.8 g/day, serum albumin level of 1...
May 15, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29725656/the-role-of-pla2r-antibody-in-treatment-of-membranous-nephropathy
#6
Karine Dahan, Valentine Gillion, Catherine Johanet, Hanna Debiec, Pierre Ronco
No abstract text is available yet for this article.
March 2018: KI Reports
https://www.readbyqxmd.com/read/29725648/nephcure-accelerating-cures-institute-a-multidisciplinary-consortium-to-improve-care-for-nephrotic-syndrome
#7
Debbie S Gipson, David T Selewski, Susan F Massengill, Mary Margaret Modes, Hailey Desmond, Lauren Lee, Elaine Kamil, Matthew R Elliott, Sharon G Adler, Gia Oh, Richard A Lafayette, Patrick E Gipson, Aditi Sinha, Arvind Bagga, Anne Pesenson, Cheryl Courtlandt, Cathie Spino, Richard Eikstadt, Renée Pitter, Samara Attalla, Anne Waldo, Richard Winneker, Noelle E Carlozzi, Jonathan P Troost, Irving Smokler, Mark Stone
Introduction: NephCure Accelerating Cures Institute (NACI) is a collaborative organization sponsored by NephCure Kidney International and the University of Michigan. The Institute is composed of 7 cores designed to improve treatment options and outcomes for patients with glomerular disease: Clinical Trials Network, Data Warehouse, Patient-Reported Outcomes (PRO) and Endpoints Consortium, Clinical Trials Consulting Team, Quality Initiatives, Education and Engagement, and Data Coordinating Center...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29700792/preventive-effect-of-shenkang-injection-against-high-glucose-induced-senescence-of-renal-tubular-cells
#8
Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He
Shenkang injection (SKI) is a classic prescription composed of Radix Astragali, rhubarb, Astragalus, Safflower, and Salvia. This treatment was approved by the State Food and Drug Administration of China in 1999 for treatment of chronic kidney diseases based on good efficacy and safety. This study aimed to investigate the protective effect of SKI against high glucose (HG)-induced renal tubular cell senescence and its underlying mechanism. Primary renal proximal tubule epithelial cells were cultured in (1) control medium (control group), medium containing 5 mmol/L glucose; (2) mannitol medium (mannitol group), medium containing 5 mmol/L glucose, and 25 mmol/L mannitol; (3) HG medium (HG group) containing 30 mmol/L glucose; (4) SKI treatment at high (200 mg/L), medium (100 mg/L), or low (50 mg/L) concentration in HG medium (HG + SKI group); or (5) 200 mg/L SKI treatment in control medium (control + SKI group) for 72 h...
April 25, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29698936/response-predictors-to-calcineurin-inhibitors-in-patients-with-primary-membranous-nephropathy
#9
Xiaofang Yu, Jieru Cai, Xiaoyan Jiao, Shu Zhang, Hong Liu, Xiaoqiang Ding
BACKGROUND: Currently, there is an urgent need to find ways of identifying primary membranous nephropathy (PMN) patients who are likely to benefit from calcineurin inhibitors (CNI) or who are resistant to them. In this study, we employed nano-HPLC-MS/MS analysis to identify serum biomarkers that predict the clinical response to CNI therapy in PMN patients. METHODS: The endpoint was complete remission (CR) after CNI treatment. PMN patients were grouped into no-remission (NR) or CR groups to screen predictive candidates using the nano-HPLC-MS/MS analysis...
April 26, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29678354/actin-dynamics-at-focal-adhesions-a-common-endpoint-and-putative-therapeutic-target-for-proteinuric-kidney-diseases
#10
REVIEW
Sanja Sever, Mario Schiffer
Proteinuria encompasses diverse causes including both genetic diseases and acquired forms such as diabetic and hypertensive nephropathy. The basis of proteinuria is a disturbance in size selectivity of the glomerular filtration barrier, which largely depends on the podocyte: a terminally differentiated epithelial cell type covering the outer surface of the glomerulus. Compromised podocyte structure is one of the earliest signs of glomerular injury. The phenotype of diverse animal models and podocyte cell culture firmly established the essential role of the actin cytoskeleton in maintaining functional podocyte structure...
April 17, 2018: Kidney International
https://www.readbyqxmd.com/read/29669425/response-to-pharmacological-treatment-of-primary-membranous-nephropathy-in-2016
#11
Nikoleta Printza, Ireni Georeli, Stella Stabouli, John Dotis, Christina Sidira, Fotios Papachristou
No abstract text is available yet for this article.
April 25, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29669314/three-novel-heterozygous-col4a4-mutations-result-in-three-different-collagen-type-iv-kidney-disease-phenotypes
#12
Ang Li, Er-Zhi Gao, Ying-Xia Cui, Jian-Hong Liu, Xing Lv, Xiu-Xiu Wei, Xin-Yi Xia, Chun-Lin Gao, Feng-Xia Liu, Zheng-Kun Xia, Asan, Zhi-Hong Liu, Xiao-Jun Li
Thin basement membrane nephropathy (TBMN), autosomal dominant Alport syndrome (ADAS), and focal segmental glomerulosclerosis (FSGS) are kidney diseases that differ in clinical diagnosis, treatment, and prognosis. Nevertheless, they may result from the same causative genes. Here, we report 3 COL4A4 heterozygous mutations (p.Gly208Arg, p.Ser513Glufs*2, and p.Met1617Cysfs*39) that lead to 3 different collagen type IV kidney disease phenotypes, manifesting as TBMN, ADAS, and FSGS. Using bioinformatics analyses and pedigree verification, we show that these novel variants are pathogenetic and cosegregate with TBMN, ADAS, and FSGS...
2018: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29657221/unusual-cause-of-crystalline-nephropathy
#13
Natarajan Gopalakrishnan, Dhanasekaran Rajasekar, Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan, T Balasubramaniyan, V Murugesan
Adenine phosphoribosyltransferase deficiency is a rare, inherited autosomal recessive disease presenting with 2,8-dihydroxyadenine (DHA) urolithiasis, DHA nephropathy, and chronic kidney disease. The presence of DHA crystals in urine and renal biopsy is pathognomonic of the disease. We report a 23-year-old female with acute renal failure and nephrotic proteinuria. Urinalysis showed reddish brown, round crystals with dark outline, and central spicules consistent with 2,8-DHA crystals. Renal biopsy showed membranous nephropathy and 2,8-DHA nephropathy...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29657214/kaposi-s-sarcoma-in-patients-with-membranous-nephropathy
#14
Weihua Liu, Feiyue Lin, Xin Chen, Lixin Wei, Jiabin Wu
Although the relationship between Kaposi's sarcoma (KS) and renal transplant has been well described, there are rare cases of KS concurrent with membranous glomerulonephritis or other glomerular diseases. In this report, a patient with membranous glomerulonephritis that accepted long-term prednisolone and cyclosporine immunosuppressive therapy developed skin KS. Withdrawal of immunosuppressive treatment resulted in the disappearance of KS.
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29649452/serum-secretory-phospholipase-a2-group-ib-correlates-with-the-severity-of-membranous-nephropathy
#15
Weihao Li, Mingming Zhang, Yaping Guo, Xiaomei Liu, Xin Ji, Junhua Su, Zhiping Zhang, Feifei Zhang
BACKGROUND: Serum secretory phospholipase A2 group IB (sPLA2-IB) is involved in the pathological processes of membranous nephropathy (MN). To date, there is no large-scale study validating the usefulness of circulating sPLA2-IB in the follow-up of patients with MN. This study investigated the role of circulating sPLA2-IB in the evaluation of severity of MN. METHODS: A total of 158 patients with primary membranous nephropathy (pMN), 34 with secondary membranous nephropathy (sMN) and 53 healthy controls were enrolled...
April 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29642511/effect-of-pinocembrin-isolated-from-mexican-brown-propolis-on-diabetic-nephropathy
#16
Jessica Granados-Pineda, Norma Uribe-Uribe, Patricia García-López, María Del Pilar Ramos-Godinez, J Fausto Rivero-Cruz, Jazmin Marlen Pérez-Rojas
Propolis is a resinous beehive product that has been used worldwide in traditional medicine to prevent and treat colds, wounds, rheumatism, heart disease and diabetes. Diabetic nephropathy is the final stage of renal complications caused by diabetes and for its treatment there are few alternatives. The present study aimed to determine the chemical composition of three propolis samples collected in Chihuahua, Durango and Zacatecas and to evaluate the effect of pinocembrin in a model of diabetic nephropathy in vivo...
April 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29620510/therapy-of-rituximab-in-idiopathic-membranous-nephropathy-with-nephrotic-syndrome-a-systematic-review-and-meta-analysis
#17
Pei-Mei Zou, Hang Li, Jian-Fang Cai, Zhen-Jie Chen, Chao Li, Xue-Wang Li
Objective To investigate the efficacy and safety of rituximab (RTX) in the treatment of idiopathic membranous nephropathy (IMN) with nephrotic syndrome with a systematic review and meta-analysis. Methods PubMed, Embase, Cochrane Library and Clinical Trials (December 2016) were searched to identify researches investigating the treatment of RTX in adult patients with biopsy-proven IMN. Complete remission (CR) or partial remission was regarded as effective therapy, and the cumulated remission rate was calculated...
March 30, 2018: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29617884/rituximab-versus-the-modified-ponticelli-regimen-in-the-treatment-of-primary-membranous-nephropathy-a-health-economic-model
#18
Patrick Hamilton, Durga Kanigicherla, Michael Venning, Paul Brenchley, David Meads
Background: Membranous nephropathy is among the most common causes of nephrotic syndrome worldwide, with a high healthcare burden. Treatment using the modified Ponticelli regimen (mPR) has remained the standard of care for decades, but newer therapies such as rituximab offer promising results with reduced side effects. The cost of this treatment, however, is perceived as a barrier to widespread use, especially in resource limited healthcare systems. Methods: We developed a decision-analytic model to estimate the cost-effectiveness of rituximab versus the mPR from the perspective of the National Health Service in the UK over a 1 year, 5 year and lifetime horizon...
March 29, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29615804/combining-streptozotocin-and-unilateral-nephrectomy-is-an-effective-method-for-inducing-experimental-diabetic-nephropathy-in-the-resistant-c57bl-6j-mouse-strain
#19
Melissa Uil, Angelique M L Scantlebery, Loes M Butter, Per W B Larsen, Onno J de Boer, Jaklien C Leemans, Sandrine Florquin, Joris J T H Roelofs
Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Animal models are essential tools for designing new strategies to prevent DN. C57Bl/6 (B6) mice are widely used for transgenic mouse models, but are relatively resistant to DN. This study aims to identify the most effective method to induce DN in a type 1 (T1D) and a type 2 diabetes (T2D) model in B6 mice. For T1D-induced DN, mice were fed a control diet, and randomised to streptozotocin (STZ) alone, STZ+unilateral nephrectomy (UNx), or vehicle/sham...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29602834/nephrin-binding-ephrin-b1-at-the-slit-diaphragm-controls-podocyte-function-through-the-jnk-pathway
#20
Yoshiyasu Fukusumi, Ying Zhang, Ryohei Yamagishi, Kanako Oda, Toru Watanabe, Katsuyuki Matsui, Hiroshi Kawachi
Background B-type ephrins are membrane-bound proteins that maintain tissue function in several organs. We previously reported that ephrin-B1 is localized at the slit diaphragm of glomerular podocytes. However, the function of ephrin-B1 at this location is unclear. Methods We analyzed the phenotype of podocyte-specific ephrin-B1 knockout mice and assessed the molecular association of ephrin-B1 and nephrin, a key molecule of the slit diaphragm, in HEK293 cells and rats with anti-nephrin antibody-induced nephropathy...
May 2018: Journal of the American Society of Nephrology: JASN
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