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Immunostimulation

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https://www.readbyqxmd.com/read/28329744/antiviral-and-immunomodulatory-effects-of-norantea-brasiliensis-choisy-on-dengue-virus-2
#1
Luciana Gomes Fialho, Vagner Pereira da Silva, Sônia Regina Nogueira Ignácio Reis, Elzinandes Leal Azeredo, Maria Auxiliadora Coelho Kaplan, Maria Raquel Figueiredo, Claire Fernandes Kubelka
BACKGROUND/AIMS: Severe dengue fever is a result of exacerbated immune responses and no specific treatments are available. We evaluated the antiviral and immunomodulatory effects of Norantea brasiliensis Choisy. METHODS: Human adherent monocytes infected in vitro with dengue virus (DENV)-2 were incubated with the crude ethanol extract from leaves (NB1) or 3 derived fractions: dichloromethane (NB3), ethyl acetate (NB5), and butanolic (NB6) partitions. The antiviral and immunomodulatory activities were determined by intracellular detection of DENV antigen within monocytes and by secreted NS1 viral protein and cytokines...
March 23, 2017: Intervirology
https://www.readbyqxmd.com/read/28322142/enhanced-release-of-immunostimulating-%C3%AE-1-3-glucan-by-autodigestion-of-the-lingzhi-medicinal-mushroom-ganoderma-lingzhi-agaricomycetes
#2
Yuina Ishimoto, Ken-Ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Hisatomi Ito, Kentaro Igami, Toshitsugu Miyazaki, Naohito Ohno
Ganoderma lingzhi is a widely used medicinal mushroom that has antioxidative effects, ameliorates insulin resistance, and improves quality of life in patients with metabolic syndrome. Potentiation of immunity is also a major function of G. lingzhi, and this has been applied in patients with cancer. Supplementing G. lingzhi into foods reduced the metastasis of cancer cells. β-l,3-glucan is an important bioactive component of G. lingzhi. In this study we enhanced the solubilization ofimmunostimulating β-l,3-glucan by autodigestion of G...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28319404/encapsulation-of-an-ep67-conjugated-ctl-peptide-vaccine-in-nanoscale-biodegradable-particles-increases-the-efficacy-of-respiratory-immunization-and-affects-the-magnitude-and-memory-subsets-of-vaccine-generated-mucosal-and-systemic-cd8-t-cells-in-a-diameter
#3
Bala Vamsi Krishna Karuturi, Shailendra B Tallapaka, Pravin Yeapuri, Stephen M Curran, Sam D Sanderson, Joseph A Vetro
The diameter of biodegradable particles used to co-encapsulate immunostimulants and subunit vaccines affects the magnitude of memory CD8(+) T cells generated by systemic immunization. Possible effects on the magnitude of CD8(+) T cells generated by mucosal immunization or memory subsets that potentially correlate more strongly with protection against certain pathogens, however, are unknown. In this study, we conjugated our novel host-derived mucosal immunostimulant, EP67, to the protective MCMV CTL epitope, pp89, through a lysosomal protease-labile double arginine linker (pp89-RR-EP67) and encapsulated in PLGA 50:50 micro- or nanoparticles...
March 20, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28315392/dietary-yeast-sterigmatomyces-halophilus-enhances-mucosal-immunity-of-gilthead-seabream-sparus-aurata-l
#4
Martha Reyes-Becerril, Crystal Guluarte, Diana Ceballos-Francisco, Carlos Angulo, M Ángeles Esteban
A yeast was isolated from hypersaline sediments, grown and phylogenetically characterized as Sterigmatomyces halophilus strainN16. The dietary administration of this yeast was studied for its effect on skin mucosal immune and antioxidant status of gilthead seabream (Sparus aurata L.). Fish were fed a commercial diet (control, non-supplemented diet), or the same commercial diet supplemented with 0.55% or 1.1% of yeast for 15 and 30 days. One month after the end of the trial, fish from all treatments were intraperitoneally injected with pathogenic Vibrio parahaemolyticus and further fed with the same diets for one week, after which fish were also sampled...
March 14, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28299311/immunostimulated-arginase-ii-expression-in-intestinal-epithelial-cells-reduces-nitric-oxide-production-and-apoptosis
#5
Maria M Talavera, Sushma Nuthakki, Hongmei Cui, Yi Jin, Yusen Liu, Leif D Nelin
Increased production of nitric oxide (NO) and subsequent local cytotoxicity to mucosal epithelial cells has been proposed as a putative mechanism involved in the development of necrotizing enterocolitis (NEC). Intestinal epithelial cells (IECs) metabolize L-arginine to either nitric oxide (NO) by NO synthase (NOS) or to L-ornithine and urea by arginase. L-ornithine is the first step in polyamine synthesis important for cell proliferation, while NO production can lead to apoptosis. We hypothesized that in IECs immunostimulation increases both NOS and arginase expression, and that arginase activity mitigates NO production and apoptosis...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28297599/coupling-of-immunostimulants-to-live-cells-through-metabolic-glycoengineering-and-bioorthogonal-click-chemistry
#6
Aline Mongis, Friedrich Piller, Véronique Piller
The present study investigated the potential of metabolic glycoengineering followed by bioorthogonal click chemistry for introducing into cell surface glycans different immunomodulating molecules. Mouse tumor models EG7 and MC38-OVA were treated with Ac4GalNAz and Ac4ManNAz followed by ligation of immunostimulants to modified cell surface glycans of the living cells through bioorthogonal click chemistry. The presence of covalently bound oligosaccharide and oligonucleotide immunostimulants could be clearly established...
March 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28289684/polyprenyl-immunostimulant-in-feline-rhinotracheitis-randomized-placebo-controlled-experimental-and-field-safety-studies
#7
Alfred M Legendre, Tanya Kuritz, Robert Eric Heidel, Vivian M Baylor
Feline rhinotracheitis is a ubiquitous disease caused by feline herpesvirus type 1 (FHV-1). The disease is easily transmissible and common in multi-cat environments where even vaccinated cats can develop clinical signs of respiratory or ocular disease or both when exposed to the virus. Prior to the work reported here, there was no licensed treatment for the disease on the market. We hypothesized that polyprenyl immunostimulant (PI), an immunomodulatory veterinary biologic, would be useful in treating feline rhinotracheitis by reducing the severity of respiratory or/and ocular disease...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28288861/biotechnology-approaches-to-produce-potent-self-adjuvanting-antigen-adjuvant-fusion-protein-subunit-vaccines
#8
REVIEW
Peter Michael Moyle
Traditional vaccination approaches (e.g. live attenuated or killed microorganisms) are among the most effective means to prevent the spread of infectious diseases. These approaches, nevertheless, have failed to yield successful vaccines against many important pathogens. To overcome this problem, methods have been developed to identify microbial components, against which protective immune responses can be elicited. Subunit antigens identified by these approaches enable the production of defined vaccines, with improved safety profiles...
March 11, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28280951/effects-of-dietary-n-3-fatty-acids-on-toll-like-receptor-activation-in-primary-leucocytes-from-atlantic-salmon-salmo-salar
#9
Marianne Arnemo, Arturas Kavaliauskis, Adriana Magalhaes Santos Andresen, Marta Bou, Gerd Marit Berge, Bente Ruyter, Tor Gjøen
The shortage of the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the international markets has led to increasing substitution of fish oil by plant oils in Atlantic salmon (Salmo salar) feed and thereby reducing the EPA and DHA content in salmon. However, the minimum required levels of these fatty acids in fish diets for securing fish health are unknown. Fish were fed with 0, 1 or 2% EPA or DHA alone or in combination of both over a period, growing from 50 to 400 g. Primary head kidney leucocytes were isolated and stimulated with Toll-like receptor (TLR) ligands to determine if EPA and DHA deficiency can affect expression of important immune genes and eicosanoid production...
March 9, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28279766/structural-characterization-of-immunostimulating-protein-sulfated-fucan-complex-extracted-from-the-body-wall-of-a-sea-cucumber-stichopus-japonicus
#10
Rong-An Cao, Utoomporn Surayot, SangGuan You
The water soluble protein-sulfated fucan (PSF) complex isolated from the body wall of Stichopus japonicus was fractionated using an anion-exchange chromatography to obtain four purified fractions (F1, F2, F3, and F4) and to investigate their structural characteristics and immuno-enhancing activities. The crude PSF and fractions mostly consisted of neutral sugars, proteins and sulfates in various proportions. Fucose was their major monosaccharide unit with small portion of mannose, glucose and galactose. The molecular weight (Mw) of the crude PSF and fractions ranged from 323...
March 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28261584/polyprenyl-immunostimulant-treatment-of-cats-with-presumptive-non-effusive-feline-infectious-peritonitis-in-a-field-study
#11
Alfred M Legendre, Tanya Kuritz, Gina Galyon, Vivian M Baylor, Robert Eric Heidel
Feline infectious peritonitis (FIP) is a fatal disease with no clinically effective treatment. This field study evaluated treatment with Polyprenyl Immunostimulant (PI) in cats with the non-effusive form of FIP. Because immune suppression is a major component in the pathology of FIP, we hypothesized that treatment with an immune system stimulant would increase survival times of cats with dry FIP. Sixty cats, diagnosed with dry FIP by primary care and specialist veterinarians and meeting the acceptance criteria, were treated with PI without intentional selection of less severe cases...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28240168/immunoprevention-of-pancreatic-cancer
#12
Chinthalapally Rao, Altaf Mohammed, Adam Asch, Naveena Janakiram
Pancreatic cancer (PC) is a deadly disease, with a 5-year survival rate of 6% and has significantly changed over the decades. It is difficult to diagnose PC patients at early stages, as there are no early non-invasive biomarkers or early signs or symptoms of clinical diagnosis. The lack of effective treatment strategies is also a major concern for hindering survival rates. Vaccine-based treatments for several cancers are currently under intense investigation. Current vaccine testing for PC is usually performed in advanced stages of cancer, during which the patient's impaired immune responses improved to suppress the growing tumor...
February 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28223005/schisandra-lignans-production-regulated-by-different-bioreactor-type
#13
Agnieszka Szopa, Adam Kokotkiewicz, Maria Luczkiewicz, Halina Ekiert
Schisandra chinensis (Chinese magnolia vine) is a rich source of therapeutically relevant dibenzocyclooctadiene lignans with anticancer, immunostimulant and hepatoprotective activities. In this work, shoot cultures of S. chinensis were grown in different types of bioreactors with the aim to select a system suitable for the large scale in vitro production of schisandra lignans. The cultures were maintained in Murashige-Skoog (MS) medium supplemented with 3mg/l 6-benzylaminopurine (BA) and 1mg/l 1-naphthaleneacetic acid (NAA)...
February 14, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28212833/dietary-administration-of-pontogammarus-maeoticus-extract-affects-immune-responses-stress-resistance-feed-intake-and-growth-performance-of-caspian-roach-rutilus-caspicus-fingerlings
#14
Rudabeh Rufchaei, Seyed Hossein Hoseinifar, Alireza Mirzajani, Hien Van Doan
Dietary administration of immunostimulants showed promising results for elevation of immune responses and disease resistance. The aim of the present study was to investigate the effects of dietary Pontogammarus (Pontogammarus maeoticus) extract on innate immune response, stress resistance, feed intake and growth performance of the Caspian roach fingerling. Two levels of P. maeoticus extract dilution with distilled water 1:25 [T1] and 1:50 [T2] were prepared. Experimental diets were prepared by top-spraying the basal diet with equal amount (2%) of diluted extracts...
February 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28197317/comparison-of-fluorinated-and-nonfluorinated-lipids-in-self-adjuvanting-delivery-systems-for-peptide-based-vaccines
#15
Waleed M Hussein, Saori Mukaida, Fazren Azmi, Stacey Bartlett, Celine Olivier, Michael R Batzloff, Michael F Good, Mariusz Skwarczynski, Istvan Toth
Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund's adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs...
February 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28183096/conditioning-immune-and-endocrine-parameters-in-humans-a-systematic-review
#16
REVIEW
Judith Tekampe, Henriët van Middendorp, Stefanie H Meeuwis, Jelle W R van Leusden, Gustavo Pacheco-López, Ad R M M Hermus, Andrea W M Evers
BACKGROUND: Conditioned pharmacological effects may provide relevant clinical opportunities to improve treatment for patients with a variety of conditions. The aim of this systematic review was to create an overview of studies in this field of research and to investigate whether specific characteristics of the study design make for successful conditioning. METHODS: The protocol of this review was registered in Prospero (PROSPERO 2015: CRD42015024148). A systematic literature search was conducted in the databases PubMed, Embase, and PsychInfo...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28182098/antioxidant-immunomodulating-and-microbial-modulating-activities-of-the-sustainable-and-ecofriendly-spirulina
#17
REVIEW
Alberto Finamore, Maura Palmery, Sarra Bensehaila, Ilaria Peluso
The highly nutritional and ecofriendly Spirulina (Arthrospira platensis) has hypolipidemic, hypoglycemic, and antihypertensive properties. Spirulina contains functional compounds, such as phenolics, phycocyanins, and polysaccharides, with antioxidant, anti-inflammatory, and immunostimulating effects. Studies conducted on Spirulina suggest that it is safe in healthy subjects, but attitude to eating probably affects the acceptability of Spirulina containing foods. Although the antioxidant effect of Spirulina is confirmed by the intervention studies, the concerted modulation of antioxidant and inflammatory responses, suggested by in vitro and animal studies, requires more confirmation in humans...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28176175/safety-and-immunogenicity-of-neoadjuvant-treatment-using-wt1-immunotherapeutic-in-combination-with-standard-therapy-in-patients-with-wt1-positive-stage-ii-iii-breast-cancer-a-randomized-phase-i-study
#18
M Higgins, G Curigliano, V Dieras, S Kuemmel, G Kunz, P A Fasching, M Campone, T Bachelot, P Krivorotko, S Chan, A Ferro, L Schwartzberg, M Gillet, P M De Sousa Alves, V Wascotte, F F Lehmann, P Goss
PURPOSE: This Phase I, multicenter, randomized study (ClinicalTrials.gov NCT01220128) evaluated the safety and immunogenicity of recombinant Wilms' tumor 1 (WT1) protein combined with the immunostimulant AS15 (WT1-immunotherapeutic) as neoadjuvant therapy administered concurrently with standard treatments in WT1-positive breast cancer patients. METHODS: Patients were treated in 4 cohorts according to neoadjuvant treatment (A: post-menopausal, hormone receptor [HR]-positive patients receiving aromatase inhibitors; B: patients receiving chemotherapy; C: HER2-overexpressing patients on trastuzumab-chemotherapy combination; D: HR-positive/HER2-negative patients on chemotherapy)...
April 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28174262/role-of-vascular-normalization-in-benefit-from-metronomic-chemotherapy
#19
Fotios Mpekris, James W Baish, Triantafyllos Stylianopoulos, Rakesh K Jain
Metronomic dosing of chemotherapy-defined as frequent administration at lower doses-has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in the clinic. Although multiple mechanisms of benefit from metronomic chemotherapy have been proposed, how these mechanisms are related to one another and which one is dominant for a given tumor-drug combination is not known. To this end, we have developed a mathematical model that incorporates various proposed mechanisms, and report here that improved function of tumor vessels is a key determinant of benefit from metronomic chemotherapy...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28160866/withania-somnifera-chemotype-nmitli-101r-significantly-increases-the-efficacy-of-antileishmanial-drugs-by-generating-strong-ifn-%C3%AE-and-il-12-mediated-immune-responses-in-leishmania-donovani-infected-hamsters
#20
Chandra Dev Pati Tripathi, Pramod Kumar Kushawaha, Rajender Singh Sangwan, Chitra Mandal, Shailja Misra-Bhattacharya, Anuradha Dube
BACKGROUND: Withania somnifera (L.) Dunal (Solanaceae), commonly known as Ashwagandha, is one of the most important medicinal plant in the traditional Indian medical systems. Pharmacological studies have established that root extracts of W. somnifera contain several bioactive constituents called withanolides. The plant has long been used for its several beneficial properties and recently as an immunomodulator. HYPOTHESIS/PURPOSE: A combination therapy including a potential and safe immunostimulant with lower doses of effective drug, which can reduce the parasitic burden and simultaneously can produce an enhancement of adaptive immunity, has proven to be significantly a more effective approach than immunotherapy or drug therapy alone...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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