keyword
MENU ▼
Read by QxMD icon Read
search

Immunostimulation

keyword
https://www.readbyqxmd.com/read/28212833/dietary-administration-of-pontogammarus-maeoticus-extract-affects-immune-responses-stress-resistance-feed-intake-and-growth-performance-of-caspian-roach-rutilus-caspicus-fingerlings
#1
Rudabeh Rufchaei, Seyed Hossein Hoseinifar, Alireza Mirzajani, Hien Van Doan
Dietary administration of immunostimulants showed promising results for elevation of immune responses and disease resistance. The aim of the present study was to investigate the effects of dietary Pontogammarus (Pontogammarus maeoticus) extract on innate immune response, stress resistance, feed intake and growth performance of the Caspian roach fingerling. Two levels of P. maeoticus extract dilution with distilled water 1:25 [T1] and 1:50 [T2] were prepared. Experimental diets were prepared by top-spraying the basal diet with equal amount (2%) of diluted extracts...
February 14, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28197317/comparison-of-fluorinated-and-nonfluorinated-lipids-in-self-adjuvanting-delivery-systems-for-peptide-based-vaccines
#2
Waleed M Hussein, Saori Mukaida, Fazren Azmi, Stacey Bartlett, Celine Olivier, Michael R Batzloff, Michael F Good, Mariusz Skwarczynski, Istvan Toth
Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund's adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs...
February 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28183096/conditioning-immune-and-endocrine-parameters-in-humans-a-systematic-review
#3
Judith Tekampe, Henriët van Middendorp, Stefanie H Meeuwis, Jelle W R van Leusden, Gustavo Pacheco-López, Ad R M M Hermus, Andrea W M Evers
BACKGROUND: Conditioned pharmacological effects may provide relevant clinical opportunities to improve treatment for patients with a variety of conditions. The aim of this systematic review was to create an overview of studies in this field of research and to investigate whether specific characteristics of the study design make for successful conditioning. METHODS: The protocol of this review was registered in Prospero (PROSPERO 2015: CRD42015024148). A systematic literature search was conducted in the databases PubMed, Embase, and PsychInfo...
February 10, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28182098/antioxidant-immunomodulating-and-microbial-modulating-activities-of-the-sustainable-and-ecofriendly-spirulina
#4
REVIEW
Alberto Finamore, Maura Palmery, Sarra Bensehaila, Ilaria Peluso
The highly nutritional and ecofriendly Spirulina (Arthrospira platensis) has hypolipidemic, hypoglycemic, and antihypertensive properties. Spirulina contains functional compounds, such as phenolics, phycocyanins, and polysaccharides, with antioxidant, anti-inflammatory, and immunostimulating effects. Studies conducted on Spirulina suggest that it is safe in healthy subjects, but attitude to eating probably affects the acceptability of Spirulina containing foods. Although the antioxidant effect of Spirulina is confirmed by the intervention studies, the concerted modulation of antioxidant and inflammatory responses, suggested by in vitro and animal studies, requires more confirmation in humans...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28176175/safety-and-immunogenicity-of-neoadjuvant-treatment-using-wt1-immunotherapeutic-in-combination-with-standard-therapy-in-patients-with-wt1-positive-stage-ii-iii-breast-cancer-a-randomized-phase-i-study
#5
M Higgins, G Curigliano, V Dieras, S Kuemmel, G Kunz, P A Fasching, M Campone, T Bachelot, P Krivorotko, S Chan, A Ferro, L Schwartzberg, M Gillet, P M De Sousa Alves, V Wascotte, F F Lehmann, P Goss
PURPOSE: This Phase I, multicenter, randomized study (ClinicalTrials.gov NCT01220128) evaluated the safety and immunogenicity of recombinant Wilms' tumor 1 (WT1) protein combined with the immunostimulant AS15 (WT1-immunotherapeutic) as neoadjuvant therapy administered concurrently with standard treatments in WT1-positive breast cancer patients. METHODS: Patients were treated in 4 cohorts according to neoadjuvant treatment (A: post-menopausal, hormone receptor [HR]-positive patients receiving aromatase inhibitors; B: patients receiving chemotherapy; C: HER2-overexpressing patients on trastuzumab-chemotherapy combination; D: HR-positive/HER2-negative patients on chemotherapy)...
February 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28174262/role-of-vascular-normalization-in-benefit-from-metronomic-chemotherapy
#6
Fotios Mpekris, James W Baish, Triantafyllos Stylianopoulos, Rakesh K Jain
Metronomic dosing of chemotherapy-defined as frequent administration at lower doses-has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in the clinic. Although multiple mechanisms of benefit from metronomic chemotherapy have been proposed, how these mechanisms are related to one another and which one is dominant for a given tumor-drug combination is not known. To this end, we have developed a mathematical model that incorporates various proposed mechanisms, and report here that improved function of tumor vessels is a key determinant of benefit from metronomic chemotherapy...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28160866/withania-somnifera-chemotype-nmitli-101r-significantly-increases-the-efficacy-of-antileishmanial-drugs-by-generating-strong-ifn-%C3%AE-and-il-12-mediated-immune-responses-in-leishmania-donovani-infected-hamsters
#7
Chandra Dev Pati Tripathi, Pramod Kumar Kushawaha, Rajender Singh Sangwan, Chitra Mandal, Shailja Misra-Bhattacharya, Anuradha Dube
BACKGROUND: Withania somnifera (L.) Dunal (Solanaceae), commonly known as Ashwagandha, is one of the most important medicinal plant in the traditional Indian medical systems. Pharmacological studies have established that root extracts of W. somnifera contain several bioactive constituents called withanolides. The plant has long been used for its several beneficial properties and recently as an immunomodulator. HYPOTHESIS/PURPOSE: A combination therapy including a potential and safe immunostimulant with lower doses of effective drug, which can reduce the parasitic burden and simultaneously can produce an enhancement of adaptive immunity, has proven to be significantly a more effective approach than immunotherapy or drug therapy alone...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28157558/genetic-polymorphism-of-interleukin-10-a592c-among-oral-cancer-with-squamous-cell-carcinoma
#8
Prithvi Kumar Singh, Mohammad Kaleem Ahmad, Vijay Kumar, Rajni Gupta, Monica Kohli, Amita Jain, Abbas Ali Mahdi, Jaishri Bogra, Girish Chandra
OBJECTIVE: Interleukin-10 (IL-10) is a pleiotropic cytokine with either immunosuppressive or immunostimulative activities. It has been reported that in cancer, the promoter region polymorphism of IL-10 (-A592C) alters both the expression and serum levels of this cytokine. In the present study, we have addressed the question as to whether the single nucleotide polymorphisms (SNPs) at positions -592 A/C in the IL-10 gene promoter, could predispose an individual to oral squamous cell carcinoma (OSCC)...
January 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28153417/association-between-chronic-organochlorine-exposure-and-immunotoxicity-in-the-round-stingray-urobatis-halleri
#9
Jillian M Sawyna, Weston R Spivia, Kelly Radecki, Deborah A Fraser, Christopher G Lowe
Chronic organochlorine (OC) exposure has been shown to cause immune impairment in numerous vertebrate species. To determine if elasmobranchs exhibited compromised immunity due to high OC contamination along the coastal mainland of southern California, innate immune function was compared in round stingrays (Urobatis halleri) collected from the mainland and Santa Catalina Island. Proliferation and phagocytosis of peripheral blood, splenic, and epigonal leukocytes were assessed. Percent phagocytosis and mean fluorescence intensity (MFI) were evaluated by quantifying % leukocytes positive for, and relative amounts of ingested fluorescent E...
January 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28152476/the-efficacy-of-sulfated-polysaccharides-from-padina-tetrastromatica-in-modulating-the-immune-functions-of-raw-264-7-cells
#10
Geena Mariya Jose, G Muraleedhara Kurup
Immunomodulation is a collective term of immunostimulation and immunosuppression. Immunotherapy by means of immunomodulation is gaining additional significance as the frequency of mutant microbes as well as cancer cases are increasing in the present time. A wide population of marine vegetation has contributed to the traditional and modern therapeutic regimens owing to the abundance of bioactive molecules. Among the seaweed born macromolecules, the sulfated polysaccharides (SPS) from marine macro algae were reported to exhibit excellent biological activities in addition to their structural and nutritional roles...
January 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28142059/intracerebral-injection-of-cpg-oligonucleotide-for-patients-with-de-novo-glioblastoma-a-phase-ii-multicentric-randomised-study
#11
Renata Ursu, Alexandre Carpentier, Philippe Metellus, Vincent Lubrano, Florence Laigle-Donadey, Laurent Capelle, Jacques Guyotat, Olivier Langlois, Luc Bauchet, Kristell Desseaux, Annick Tibi, Olivier Chinot, Jérôme Lambert, Antoine F Carpentier
BACKGROUND: Immunostimulating oligodeoxynucleotides containing unmethylated cytosine-guanosine motifs (CpG-ODN) have shown a promising efficacy in several cancer models when injected locally. A previous phase II study of CpG-ODN in patients with recurrent glioblastoma (GBM) has suggested some activity and has shown a limited toxicity. This multicentre single-blinded randomised phase II trial was designed to study the efficacy of a local treatment by CpG-ODN in patients with de novo glioblastomas...
March 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28137271/microwave-ablation-combined-with-ok-432-induces-th1-type-response-and-specific-antitumor-immunity-in-a-murine-model-of-breast-cancer
#12
Li Li, Wei Wang, Hong Pan, Ge Ma, Xinyi Shi, Hui Xie, Xiaoan Liu, Qiang Ding, Wenbin Zhou, Shui Wang
BACKGROUND: Minimally invasive therapies, such as microwave ablation (MWA), are widely used for the treatment of solid tumors. Previous studies suggest that MWA is feasible for the treatment of small breast cancer, and thermal ablation may induce adaptive antitumor immunity. However, the induced immune responses are mostly weak, and the immunomodulation effects of MWA in breast cancer are unclear. Immunostimulant OK-432 can induce tumor-specific T-cell responses and may augment the immunity induced by MWA...
January 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28137189/heat-killed-cell-preparation-of-corynebacterium-glutamicum-stimulates-the-immune-activity-and-improves-survival-of-mice-against-enterohemorrhagic-escherichia-coli
#13
Makoto Ebisawa, Takamitsu Tsukahara, Ryosuke Fudou, Yasuhiro Ohta, Mitsunori Tokura, Norimasa Onishi, Takeshi Fujieda
Fermentation by Corynebacterium glutamicum is used by various industries to produce L-Glutamate, and the heat-killed cell preparation of this bacterium (HCCG) is a by-product of the fermentation process. In present study, we evaluated the immunostimulating and survival effects against enterohemorrhagic Escherichia coli (STEC) infection of HCCG. HCCG significantly stimulated in vitro IgA and interleukin-12 p70 production in murine Peyer's patch cells and peritoneal macrophages, respectively. Oral administration of 10 mg/kg body weight (BW) of HCCG for seven consecutive days stimulated IgA concentration in murine cecal digesta...
January 30, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28134402/-severe-neutropenia-during-treatment-with-amoxicillin-clavulanic-acid-in-a-patient-on-regular-hemodialysis-treatment
#14
Nicola Spetrino, Marta Arazzi, Giorgia Di Fulvio, Federica Giunta, Xhensila Grabocka, Maria Olimpia Longo, Gabriella Micioni, Alessandro Pezzutto, Simona Silvestri, Marco Tondo, Giacinta Vigilante, Mario Bonomini
Beta-lactams are one of the most widely used antibiotics in respiratory diseases, both in adults and in the pediatric population. Their widespread use is also linked to the elevated tolerability and low risk of side effects that are generally not severe. We present here the case of a patient on regular haemodialysis pertaining to our Center who, after a seven-day treatment period with amoxicillin/clavulanic acid antibiotic therapy (medication originator), developed a framework of severe neutropenia (neutrophils till 10/mmc) resulting in hospitalization and the beginning of a specific diagnostic and therapeutic work-up...
November 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28126556/debaryomyces-hansenii-up-regulates-superoxide-dismutase-gene-expression-and-enhances-the-immune-response-and-survival-in-pacific-red-snapper-lutjanus-peru-leukocytes-after-vibrio-parahaemolyticus-infection
#15
Carlos Angulo, Minerva Maldonado, Karen Delgado, Martha Reyes-Becerril
Application of yeast is increasing to improve welfare and promotes growth in aquaculture. The halotolerant yeast Debaryomyces hansenii is normally a non-pathogenic yeast with probiotic properties and potential source of antioxidant enzymes as superoxide dismutase. Here, first, we characterized the sequence features of MnSOD and icCu/ZnSOD from Pacific red snapper, and second, we evaluated the potential antioxidant immune responses of the marine yeast Debaryomyces hansenii strain CBS004 in leukocytes which were then subjected to Vibrio parahaemolyticus infection...
January 23, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28117590/structural-characterization-of-a-novel-polysaccharide-from-lepidium-meyenii-maca-and-analysis-of-its-regulatory-function-in-macrophage-polarization-in-vitro
#16
Mengmeng Zhang, Wenjia Wu, Yao Ren, Xiaofeng Li, Yuqian Tang, Tian Min, Furao Lai, Hui Wu
In our previous study, three novel polysaccharides, named MC-1, MC-2, and MC-3, were separated from the roots of maca (Lepidium meyenii), which is a food source from the Andes region. The structural information and immunomodulatory activity of MC-1 were then investigated. The structure and activity of MC-2 are still unknown. In this study, structural characterization revealed that MC-2 has an average molecular weight of 9.83 kDa and is composed of arabinose (20.9%), mannose (4.5%), glucose (71.9%), and galactose (2...
February 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28105852/the-effect-of-isoprinosine-treatment-on-persistent-infection-of-balb-c-mice-infected-with-murine-gammaherpesvirus-68-mhv-68
#17
O Janíčková, L Ančicová, K Briestenská, J Mistríková
We demonstrated the positive effect of Isoprinosine treatment on persistent infection of Balb/c mice with MHV-68. Increased number of leukocytes, increased percentage of neutrophils, elevated levels of virus-neutralizing (VN) antibodies, reduced number of atypical lymphocytes and reduced virus titers were detected in the examined organs after a 14-day treatment. The positive effect of Isoprinosine therapy vanished after 120-150 days. After this interval, we demonstrated lower numbers of leukocytes, lower levels of VN antibodies and an increased number of atypical lymphoid monocytes in the Isoprinosine-treated group...
January 25, 2017: Acta Virologica
https://www.readbyqxmd.com/read/28089932/selenizing-hericium-erinaceus-polysaccharides-induces-dendritic-cells-maturation-through-mapk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#18
Tao Qin, Zhe Ren, Yifan Huang, Yulong Song, Dandan Lin, Jian Li, Yufang Ma, Xiuqin Wu, Fuan Qiu, Qi Xiao
In this study, polysaccharides extracted from Hericium erinaceus were modified to obtain its nine selenium derivatives, sHEP1-sHEP9. Their structures were identified, yields and selenium contents were determined, the phenotypic and functional maturation of murine bone marrow-derived dendritic cells (DCs) and relevant mechanisms were compared taking unmodified HEP as control. The results revealed that the selenylation were successful. sHEP1, sHEP2 and sHEP8 treatment of DCs increased their surface expression of MHC-II and CD86 and indicated that sHEP1, sHEP2 and sHEP8 induced DC maturation...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28077441/predicting-ifn-%C3%AE-responses-after-bcg-vaccination-in-humans-from-macaques-a-proof-of-concept-study-of-immunostimulation-immunodynamic-modelling-methods
#19
Sophie J Rhodes, Charlotte Sarfas, Gwenan M Knight, Andrew White, Ansar A Pathan, Helen McShane, Thomas G Evans, Helen Fletcher, Sally Sharpe, Richard G White
INTRODUCTION: Macaques play a central role in human tuberculosis(TB) vaccine development. Immune and challenge responses differ across macaque and human subpopulations. We determined which macaque subpopulations best predicted immune responses in different human subpopulations, using novel immunostimulation/immunodynamic modelling methods in a proof of concept study. METHODS: Data on IFN-γ secreting CD4+ T cells over time after recent BCG vaccination were available for 55 humans and 81 macaques...
January 11, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28049494/adjuvant-effects-of-a-sequence-engineered-mrna-vaccine-translational-profiling-demonstrates-similar-human-and-murine-innate-response
#20
Darin K Edwards, Edith Jasny, Heesik Yoon, Nigel Horscroft, Brian Schanen, Tanya Geter, Mariola Fotin-Mleczek, Benjamin Petsch, Vaughan Wittman
BACKGROUND: Prophylactic and therapeutic vaccines often depend upon a strong activation of the innate immune system to drive a potent adaptive immune response, often mediated by a strong adjuvant. For a number of adjuvants immunological readouts may not be consistent across species. METHODS: In this study, we evaluated the innate immunostimulatory potential of mRNA vaccines in both humans and mice, using a novel mRNA-based vaccine encoding influenza A hemagglutinin of the pandemic strain H1N1pdm09 as a model...
January 3, 2017: Journal of Translational Medicine
keyword
keyword
63246
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"