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Immunostimulant

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https://www.readbyqxmd.com/read/29045781/development-of-clickable-monophosphoryl-lipid-as-towards-semi-synthetic-conjugates-with-tumor-associated-carbohydrate-antigens
#1
Marcello Ziaco, Sabina Górska, Serena Traboni, Agnieszka Maria Razim, Angela Casillo, Alfonso Iadonisi, Andrzej Gamian, Maria Michela Corsaro, Emiliano Bedini
A semi-synthetic strategy for the obtainment of monophosphoryl lipid A derivatives equipped with clickable (azide, alkyne, double bond, a thiol precursor) moieties, starting from the native lipid A isolated from Escherichia coli, is here presented. These lipid A derivatives can be conjugated with other interesting biomolecules, such as tumor-associated carbohydrate antigens (TACAs). In this way, the immunostimulant activity of monophosphoryl lipid A can significantly improve the immunogenicity of TACAs, thus opening an access to potential self-adjuvant anticancer vaccine candidates...
October 18, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29039977/chronic-disruptions-of-circadian-sleep-regulation-induce-specific-proinflammatory-responses-in-the-rat-colon
#2
Lenka Polidarová, Pavel Houdek, Alena Sumová
Exposure to environmental conditions that disturb the daily rhythms has been shown to enhance the proinflammatory responses of immunostimulant-challenged immune system. However, it is not known whether circadian disturbances may stimulate unchallenged immune responses and thus contribute per se to the development of inflammation-related diseases. Our aim was to ascertain an effect of various conditions threatening the behavioral activity/rest cycle regulation, namely aging with or without melatonin, 6 h advance/delay phase shifts in the light/dark cycle repeated with a 2-day frequency and constant light, on expression of immune markers in the rat colon...
October 17, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29038769/polysaccharide-from-black-currant-ribes-nigrum-l-stimulates-dendritic-cells-through-tlr4-signaling
#3
Hiroshi Ashigai, Yuta Komano, Guanying Wang, Yasuji Kawachi, Kazuko Sunaga, Reiko Yamamoto, Ryoji Takata, Mika Miyake, Takaaki Yanai
Black currant (Ribes nigrum) has various beneficial properties for human health. In particular, polysaccharide from black currant was found to be an immunostimulating food ingredient and was reported to have antitumor activity in a mouse model. We named it cassis polysaccharide (CAPS). In a previous study, CAPS administration caused tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) production in vitro and in vivo, but the immunological mechanism of CAPS was not demonstrated. In this study, we revealed the CAPS immunostimulating mechanism in vitro...
2017: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/29034747/long-term-supplementation-of-rhodiola-kirilowii-extracts-during-pregnancy-and-lactation-does-not-affect-mother-health-status
#4
Sławomir Lewicki, Ewa Skopińska-Różewska, Aneta Lewicka, Robert Zdanowski
Antibiotics treatment during pregnancy and lactation is problematic. The alternative to the antibiotic treatment is the use of plant-derived supplements, which stimulate immune system to prevent and eliminate bacterial infection. Here we evaluated the effect of long-term use of Rhodiola kirilowii on the health of mouse mothers. Pregnant mice were fed daily, for whole pregnancy and for 28 days after giving birth, with Rhodiola kirilowii water (RKW) or hydroalcoholic extract (RKW-A) (at 20 mg of extracts/kg)...
October 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29032039/the-efficacy-of-poly-%C3%AE-hydroxy-butyrate-phb-biosurfactant-derived-from-staphylococcus-hominis-against-white-spot-syndrome-virus-wssv-in-penaeus-monodon
#5
M Monica, T Priyanka, Akshaya Murugesan, V Rajeswari, Sivakumar Lingappa, S T Somasundaram, R Shenbhagarathai
White Spot Syndrome Virus (WSSV) is one of the most important causative agents of Penaeid shrimps diseases that incur heavy losses to the shrimp aquaculture. It has severe impact on the sustainability and the production of Penaeus monodon. Hence, the present study focussed on the investigation of Poly-β-hydroxybutyrate/biosurfactant as immunostimulants against WSSV infected shrimps. Infection of WSSV was periodically checked in all the experimental shrimps using PCR diagnostic kit. After ensuring all shrimps were free of viral infection, experiments were carried out to analyze the nonspecific immune responses (prophenol oxidase, nitro blue tetrazolium reduction assay and total haemocyte count) both in control and experimental group...
October 11, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29031816/designing-immunostimulatory-double-stranded-messenger-rna-with-maintained-translational-activity-through-hybridization-with-poly-a-sequences-for-effective-vaccination
#6
Satoshi Uchida, Naoto Yoshinaga, Kayoko Yanagihara, Eiji Yuba, Kazunori Kataoka, Keiji Itaka
Messenger (m)RNA vaccines require a safe and potent immunostimulatory adjuvant. In this study, we introduced immunostimulatory properties directly into mRNA molecules by hybridizing them with complementary RNA to create highly immunogenic double stranded (ds)RNAs. These dsRNA formulations, comprised entirely of RNA, are expected to be safe and highly efficient due to antigen expression and immunostimulation occurring simultaneously in the same antigen presenting cells. In this strategy, design of dsRNA is important...
September 27, 2017: Biomaterials
https://www.readbyqxmd.com/read/29027229/extracellular-nucleosides-and-nucleotides-as-immunomodulators
#7
REVIEW
Oliver Kepp, Friedemann Loos, Peng Liu, Guido Kroemer
Some anticancer agents induce immunogenic cell death that is accompanied by the emission of danger signals into the tumor microenvironment, thus attracting and activating innate immune effectors and finally inducing anticancer immunity. The release of extracellular nucleosides such as adenosine triphosphate (ATP) from the tumor in response to anticancer therapy plays a pivotal role in the attraction of antigen presenting cells and the activation of inflammasome-mediated proinflammatory cascades. In contrast, the ectonucleotidase-catalyzed phosphohydrolysis of nucleotides to nucleosides reduces the extracellular availability of nucleotides, hence limiting the recruitment and activation of antigen-presenting cells...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29024788/thermostability-of-the-coating-antigen-and-immunostimulator-in-an-adjuvanted-oral-capsule-vaccine-formulation
#8
Stephanie Longet, Vincenzo Aversa, Daire O'Donnell, Joshua Tobias, Monica Rosa, Jan Holmgren, Ivan S Coulter, Ed C Lavelle
Oral vaccines present an attractive alternative to injectable vaccines for enteric diseases due to ease of delivery and the induction of intestinal immunity at the site of infection. However, susceptibility to gastrointestinal proteolysis, limited transepithelial uptake and a lack of clinically acceptable adjuvants present significant challenges. A further challenge to mass vaccination in developing countries is the very expensive requirement to maintain the cold chain. We recently described the effectiveness of a Single Multiple Pill(®) (SmPill(®)) adjuvanted capsule approach to enhance the effectiveness of a candidate enterotoxigenic Escherichia coli (ETEC) oral vaccine...
October 9, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29024595/organelle-specific-triggered-release-of-immunostimulatory-oligonucleotides-from-intrinsically-coordinated-dna-metal-organic-frameworks-with-soluble-exoskeleton
#9
Zejun Wang, Yao Fu, Zhengzhong Kang, Xiaoguo Liu, Nan Chen, Qi Wang, Yaoquan Tu, Lihua Wang, Shiping Song, Daishun Ling, Haiyun Song, Xueqian Kong, Chunhai Fan
DNA has proven of high utility to modulate the surface functionality of metal-organic frameworks (MOFs) for various biomedical applications. Nevertheless, current methods for preparing DNA-MOF nanoparticles rely on either inefficient covalent conjugation or specific modification of oligonucleotides. In this work, we report that unmodified oligonucleotides can be loaded on MOFs with high density (~2,500 strands/particle) via intrinsic, multivalent coordination between DNA backbone phosphate and unsaturated zirconium sites on MOFs...
October 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29021503/characterization-of-the-chemical-structure-and-innate-immune-stimulating-activity-of-an-extracellular-polysaccharide-from-rhizobium-sp-strain-m2-screened-using-a-silkworm-muscle-contraction-assay
#10
Makoto Urai, Tomoko Aizawa, Katsutoshi Imamura, Hiroshi Hamamoto, Kazuhisa Sekimizu
We screened innate immunostimulant-producing bacteria using a silkworm muscle contraction assay, and isolated Rhizobium sp. strain M2 from soil. We purified the innate immunostimulant from strain M2, and characterized the chemical structure by nuclear magnetic resonance spectroscopy and chemical analyses. The innate immunostimulant (M2 EPS) comprised glucose, galactose, pyruvic acid, and succinic acid with a molar ratio of 6.8:1.0:0.9:0.4, and had a succinoglycan-like high molecular-weight heteropolysaccharide structure...
October 11, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29021502/structural-analysis-of-an-innate-immunostimulant-from-broccoli-brassica-oleracea-var-italica
#11
Makoto Urai, Keiko Kataoka, Satoshi Nishida, Kazuhisa Sekimizu
Vegetables are eaten as part of a healthy diet throughout the world, and some are also applied topically as a traditional medicine. We evaluated the innate immunostimulating activities of hot water extracts of various vegetables using the silkworm muscle contraction assay system, and found that broccoli, Brassica oleracea var. italica, contains a strong innate immunostimulant. We purified the innate immunostimulant from broccoli, and characterized the chemical structure by chemical analyses and NMR spectroscopy...
October 11, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29019573/use-of-transfer-factor-in-immunosuppressed-surgical-patients
#12
Celia Regina Oliveira Garritano, Francesco di Nubila, Renata M Couto, Rossano Kepler Alvim Fiorelli, Luciana Berti Aun
OBJECTIVE: to evaluate the action of Transfer Factor on the immune response of patients with malignant neoplasm submitted to surgery, chemotherapy and radiotherapy. METHOD: we analyzed the variations of leukocytes, total lymphocytes, T-lymphocytes and CD4 counts in 60 patients submitted to immunostimulation with a single, daily dose of 0.5mg sublingual Transfer Factor, started simultaneously with chemotherapy and/or radiotherapy. RESULTS: there were statistically significant increases in the counts of all cell lines studied, more pronounced after 12 months of use of the medication...
September 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29017942/as-cath4-and-5-two-vertebrate-derived-natural-host-defense-peptides-enhance-the-immuno-resistance-efficiency-against-bacterial-infections-in-chinese-mitten-crab-eriocheir-sinensis
#13
Zhilai Guo, Xue Qiao, Ruomei Cheng, Nannan Shi, Aili Wang, Tingting Feng, Yan Chen, Fen Zhang, Haining Yu, Yipeng Wang
Host defense peptides (HDPs), a class of conserved components of animal innate immune system, possess direct antimicrobial activities against invading pathogens and broadly participate in boosting and modulating host immune responses. Cathelicidins is an important family of HDPs that has been identified exclusively in vertebrates. Considering the relatively conserved innate immune system between invertebrates and vertebrates, it is speculated that HDPs from vertebrates may also possess modulating functions on invertebrate innate immune system...
October 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28993779/natural-killer-cell-response-to-chemotherapy-stressed-cancer-cells-role-in-tumor-immunosurveillance
#14
REVIEW
Alessandra Zingoni, Cinzia Fionda, Cristiana Borrelli, Marco Cippitelli, Angela Santoni, Alessandra Soriani
Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance. An equilibrium between immune control and tumor growth is maintained as long as cancer cells evade immunosurveillance. Therapies designed to kill cancer cells and to simultaneously sustain host antitumor immunity are an appealing strategy to control tumor growth. Several chemotherapeutic agents, depending on which drugs and doses are used, give rise to DNA damage and cancer cell death by means of apoptosis, immunogenic cell death, or other forms of non-apoptotic death (i...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28986213/characterization-of-nuclear-factor-of-activated-t-cells-c3-nfatc3-and-gene-expression-of-upstream-downstream-signaling-molecules-in-response-to-immunostimulants-in-pacific-red-snapper-cells
#15
Carlos Angulo, Erika Alamillo, Felipe Ascencio, Martha Reyes-Becerril
The nuclear factor of activated T cells (NFAT) proteins have crucial roles in the development and function of the immune system since they not only regulate activation of T cells but are also involved in the control of thymocyte development and T-cell differentiation. In this study, NFATc3 was characterized from the Pacific red snapper, Lutjanus peru. LpNFAtc3, which contains an open reading of 3300 bp frame coding for a protein of 1100 aa with a predicted molecular weight of 118.52 kDa. The predicted protein showed a conserved NFAT family structure with signature motifs and domains, sharing high identity (up to 76%) compared to other fish sequences...
October 3, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28983786/comparison-of-byakujutsu-atractylodes-rhizome-and-sojutsu-atractylodes-lancea-rhizome-on-anti-inflammatory-and-immunostimulative-effects-in-vitro
#16
Yohta Shimato, Misato Ota, Kohshi Asai, Toshiyuki Atsumi, Yoshiaki Tabuchi, Toshiaki Makino
The Japanese Pharmacopoeia defines byakujutsu (Atractylodes rhizome) as the rhizome of Atractylodes japonica or A. macrocephala and sojutsu (Atractylodes lancea rhizome) as the rhizome of A. lancea, A. chinensis, or their interspecific hybrids. Because their pharmaceutical uses differ in traditional Japanese Kampo medicine and traditional Chinese medicine, with less apparent scientific evidence, we compared the pharmacological properties between byakujutsu and sojutsu. Crude drug specimens of byakujutsu (n = 40) and sojutsu (n = 49) obtained in markets were identified by their species using DNA profiling...
October 5, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28976123/immunostimulant-and-chemoprotective-effect-of-vivartana-a-polyherbal-formulation-against-cyclophosphamide-induced-toxicity-in-swiss-albino-mice
#17
Sadhana Gnanasekaran, Kunnathur Murugesan Sakthivel, Guruvayoorappan Chandrasekaran
The aim of the study is to develop a technology for cost effective immunomodulator from natural products to combat adverse effects during cancer chemotherapy. In the present study, the immunomodulatory efficacy of Vivartana, a poly herbal formulation in immunosuppressed animal model induced by cyclophosphamide (CTX) and its comparison with standard herbal immunostimulators Chyawanprash and Brahma Rasayana was investigated. The effect of Vivartana (500 mg/kg.bw) (p.o.), Chyawanprash (20 mg/kg.bw) (p.o.) and Brahma Rasayana (20 mg/kg...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28975891/local-immune-response-in-cutaneous-basal-cell-carcinoma
#18
Silje Haukali Omland
BCC is an immunogenic tumor highlighted by the increased risk in immunosuppressed individuals and the frequent occurrence of tumor infiltrating lymphocytes (TILs) in the tumor surroundings. Immunotherapy is evolving as a promising treatment strategy for several cancer types where topical immunostimulators are among the possibilities for superficial BCC. The overall aim of this thesis is to characterize the immunologic response upon BCC as well as characterizing the surrounding tumor stroma. The aim was achieved by the use of a variety of laboratory techniques; immunohistochemistry, immunoflourescence, qRT-PCR and NGS...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28971770/marine-natural-product-bis-indole-alkaloid-caulerpin-chemistry-and-biology
#19
Jignesh Lunagariya, Poonam Bhadja, Shenghui Zhong, Rohit Vekariya, Shihai Xu
Marine bis-indole alkaloids comprise a large and increasingly growing class of secondary metabolites, and continue to deliver a great variety of structural templates. The alkaloids derived from marine resources play a crucial role in medicinal chemistry and as chemical agents. In particular, bis-indole alkaloid caulerpin isolated from marine green algae Caulerpa and a red algae Chondria armata at various places around the world, and tested against several therapeutic areas such as anti-diabetic, antinociceptive, anti-inflammatory, anti-tumor, anti-larvicidal, anti-herpes, anti-tubercular, anti-microbial and immunostimulating activity as well as means of other chemical agents...
September 27, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28971270/calcium-calmodulin-dependent-protein-kinase-iv-camkiv-mediates-acute-skeletal-muscle-inflammatory-response
#20
DanDan Shi, RuiCai Gu, YaFeng Song, MaoChao Ding, Tao Huang, MengXia Guo, JiangWei Xiao, WenHua Huang, Hua Liao
The objective of this study is to investigate the role of Calmodulin-dependent protein kinase IV (CaMKIV) in Cardiotoxin (CTX)-induced mice muscle inflammation. CTX injection i.m. was performed to induce B6 mice acute tibialis anterior (TA) muscle injury. The mice were then injected i.p. with the recombinant CaMKIV protein or its antagonist KN-93. Immunoblotting was used to assess Calmodulin (CaM) and CaMKIV levels. Immunofluorescence was used to detect intramuscular infiltration or major histocompatibility complex (MHC)-I expression in damaged muscle...
October 2, 2017: Inflammation
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