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stem cell arthritis

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https://www.readbyqxmd.com/read/29323140/loss-of-a20-in-bm-mscs-regulates-the-th17-treg-balance-in-rheumatoid-arthritis
#1
Zhuan Feng, Yue Zhai, Zhaohui Zheng, Lijie Yang, Xing Luo, Xiwen Dong, Qing Han, Jin Jin, Zhi-Nan Chen, Ping Zhu
Mesenchymal stem cells (MSCs) are multi-potent cells that are self-renewable and possess the potential to differentiate into multiple lineages. Several studies demonstrated that MSCs could regulate a Th17/Treg balance and could be a potential therapeutic target for Rheumatoid Arthritis (RA). A20 is highly expressed in many cell types after the stimulation of TNF-α, where it may inhibit pro-inflammatory cytokine secretion. However, the expression of A20 in BM-MSCs in RA is not fully understood. In our study, we found that A20 was decreased in RA patients' bone marrow MSCs (BM-MSCs), and with more IL-6 secretion, the balance of Th17/Treg was broken...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321825/umbilical-cord-blood-stem-cell-treatment-for-a-patient-with-psoriatic-arthritis
#2
Margaret Coutts, Rowena Soriano, Rajendran Naidoo, Habib Torfi
Clinical and laboratory results document psoriatic arthritis in a 56-year old patient. The symptoms did not resolve with standard treatments (nonsteroidal anti-inflammatory drugs, steroids and methotrexate). TNF-alpha inhibitors (certolizumab pegol and adalimumab) were added to the treatment regime, with some adverse effects. A trial of human umbilical cord stem cell therapy was then initiated. The stem cells were enriched and concentrated from whole cord blood, by removal of erythrocytes and centrifugation...
December 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/29315262/intraarticularly-injected-mesenchymal-stem-cells-stimulate-anti-inflammatory-molecules-and-inhibit-pain-related-protein-and-chondrolytic-enzymes-in-a-monoiodoacetate-induced-rat-arthritis-model
#3
Toru Ichiseki, Miyako Shimazaki, Yoshimichi Ueda, Shusuke Ueda, Masanobu Tsuchiya, Daisuke Souma, Ayumi Kaneuji, Norio Kawahara
Persistent inflammation is well known to promote the progression of arthropathy. mesenchymal stem cells (MSCs) have been shown to possess anti-inflammatory properties and tissue differentiation potency. Although the experience so far with the intraarticular administration of mesenchymal stem cell (MSC) to induce cartilage regeneration has been disappointing, MSC implantation is now being attempted using various surgical techniques. Meanwhile, prevention of osteoarthritis (OA) progression and pain control remain important components of the treatment of early-stage OA...
January 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29296847/hsc-extrinsic-sex-related-and-intrinsic-autoimmune-disease-related-human-b-cell-variation-is-recapitulated-in-humanized-mice
#4
Chiara Borsotti, Nichole M Danzl, Grace Nauman, Markus A Hölzl, Clare French, Estefania Chavez, Mohsen Khosravi-Maharlooei, Salome Glauzy, Fabien R Delmotte, Eric Meffre, David G Savage, Sean R Campbell, Robin Goland, Ellen Greenberg, Jing Bi, Prakash Satwani, Suxiao Yang, Joan Bathon, Robert Winchester, Megan Sykes
B cells play a major role in antigen presentation and antibody production in the development of autoimmune diseases, and some of these diseases disproportionally occur in females. Moreover, immune responses tend to be stronger in female vs male humans and mice. Because it is challenging to distinguish intrinsic from extrinsic influences on human immune responses, we used a personalized immune (PI) humanized mouse model, in which immune systems were generated de novo from adult human hematopoietic stem cells (HSCs) in immunodeficient mice...
October 24, 2017: Blood Advances
https://www.readbyqxmd.com/read/29283375/role-of-stem-cells-in-pathophysiology-and-therapy-of-spondyloarthropathies-new-therapeutic-possibilities
#5
REVIEW
Magdalena Krajewska-Włodarczyk, Agnieszka Owczarczyk-Saczonek, Waldemar Placek, Adam Osowski, Piotr Engelgardt, Joanna Wojtkiewicz
Considerable progress has been made recently in understanding the complex pathogenesis and treatment of spondyloarthropathies (SpA). Currently, along with traditional disease modifying anti-rheumatic drugs (DMARDs), TNF-α, IL-12/23 and IL-17 are available for treatment of such diseases as ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Although they adequately control inflammatory symptoms, they do not affect the abnormal bone formation processes associated with SpA. However, the traditional therapeutic approach does not cover the regenerative treatment of damaged tissues...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29258883/cartilage-regeneration-and-ageing-targeting-cellular-plasticity-in-osteoarthritis
#6
REVIEW
Marta Varela-Eirin, Jesus Loureiro, Eduardo Fonseca, Silvia Corrochano, Jose R Caeiro, Manuel Collado, Maria D Mayan
Ageing processes play a major contributing role for the development of Osteoarthritis (OA). This prototypic degenerative condition of ageing is the most common form of arthritis and is accompanied by a general decline, chronic pain and mobility deficits. The disease is primarily characterized by articular cartilage degradation, followed by subchondral bone thickening, osteophyte formation, synovial inflammation and joint degeneration. In the early stages, osteoarthritic chondrocytes undergo phenotypic changes that increase cell proliferation and cluster formation and enhance the production of matrix-remodelling enzymes...
December 16, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/29238019/-inflammation-and-osteoclasts
#7
Kazuhiro Yokota
  Osteoclasts are differentiated from precursors of the monocyte/macrophage lineage originated from bone marrow hematopoietic stem cells and are the sole bone-resorbing cells in the body. Osteoclast differentiation is thought to require M-CSF (macrophage colony-stimulating factor) and RANKL (receptor activator of nuclear factor kappa-B ligand) signaling. However, it has recently been proposed that under chronic inflammatory conditions, such as systemic autoimmune diseases (e.g., rheumatoid arthritis), an increase in inflammatory cytokine levels within joints induces pathological osteoclast differentiation, causing excessive bone resorption...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29238018/-regulation-of-bone-by-il-17-producing-t-cells
#8
Kazuo Okamoto
  Bone is a component of the skeletal-locomotor system but also functions as an immunological organ that harbors hematopoietic stem and progenitor cells. Since the immune and skeletal systems are closely related through a number of shared regulatory molecules including cytokines and receptors, bone can be affected in various immune disorders. Rheumatoid arthritis is a typical disease in which the immune system affects the bone metabolism. The enhanced activity of osteoclasts by the activation of Th17 cells causes the joint destruction in rheumatoid arthritis...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29212384/articular-and-subcutaneous-adipose-tissues-of-rheumatoid-arthritis-patients-represent-equal-sources-of-immunoregulatory-mesenchymal-stem-cells
#9
Urszula Skalska, Ewa Kuca-Warnawin, Anna Kornatka, Iwona Janicka, Urszula Musiałowicz, Tomasz Burakowski, Ewa Kontny
Adipose-derived mesenchymal stem cells (ASCs) have immunoregulatory properties, but their activity is dependent on signals provided by the local microenvironment. It is likely that highly inflammatory milieu of rheumatoid joint affects ASCs activity. To test this hypothesis, the function of rheumatoid ASCs derived from articular adipose tissue (AT-ASCs) and ASCs derived from subcutaneous adipose tissue (Sc-ASCs) has been analysed. Articular adipose tissue (infrapatellar fat pad) and subcutaneous adipose tissue (from the site of skin closure with sutures) were obtained from rheumatoid arthritis (RA) patients undergoing total knee joint replacement surgery...
December 6, 2017: Autoimmunity
https://www.readbyqxmd.com/read/29203226/innately-versatile-%C3%AE-%C3%AE-17%C3%A2-t-cells-in-inflammatory-and-autoimmune-diseases
#10
REVIEW
Pedro H Papotto, Annika Reinhardt, Immo Prinz, Bruno Silva-Santos
IL-17-producing γδ (γδ17) T cells form a versatile subset of cells that respond rapidly to innate stimuli and support the pro-inflammatory functions of different myeloid and lymphoid lineages, being particularly critical in the early stages of inflammatory and autoimmune responses. In mice, under homeostatic conditions, these innate-like lymphocytes are pre-programmed in the fetal thymus, through an intricate process involving both T cell receptor-dependent and -independent signals, which allows them to readily produce IL-17 upon stimulation...
December 1, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29199605/modeling-mesenchymal-stem-cells-in-tmj-rheumatoid-arthritis-and-osteoarthritis-therapy
#11
Nedime Serakinci, Gokce Savtekin
Stem cells have self-renewal capacity and an ability to differentiate into particular cell types generating mature cells. Mesenchymal stem cells (MSCs) have a significant role in tissue homeostasis, which leads into tissue regeneration. MSCs are rare pluripotent cells supporting hematopoietic and mesenchymal cell lineages. MSCs are also believed to have therapeutic power over temporomandibular joint (TMJ) disorders (TMDs). The most common type of TMD is articular disc displacement, which induces progressive degenerative changes...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29137353/mesenchymal-stem-cells-inhibit-rank-rankl-interactions-between-osteoclasts-and-th17-cells-via-osteoprotegerin-activity
#12
Kyung-Ah Cho, Minhwa Park, Yu-Hee Kim, Kyung-Ha Ryu, So-Youn Woo
Th17 cells play a critical role in several autoimmune diseases, including psoriasis and psoriatic arthritis (PsA). Psoriasis is a chronic inflammatory skin disease associated with systemic inflammation and comorbidities, such as PsA. PsA develops in nearly 70% of patients with psoriasis, and osteoclasts associated bone erosion is a hallmark of the disease. Thus far, the effect of Th17 cells on osteoclastogenesis via direct cell-to-cell interactions is less understood. In this study, we observed that Th17 cells directly promote osteoclast differentiation and maturation via expression of receptor activator of nuclear factor-κ β ligand (RANKL) in vitro...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29127519/neutrophil-biology-within-hepatic-environment
#13
REVIEW
Débora Moreira Alvarenga, Matheus Silvério Mattos, Alan Moreira Araújo, Maísa Mota Antunes, Gustavo Batista Menezes
Neutrophils are the most abundant leukocyte in the human circulation. These short-lived cells are constantly produced from hematopoietic stem cells (HSC) within the bone marrow from which they daily reach the blood and perform major roles in innate immunity. Neutrophils are the first cells to reach inflamed tissues and are armed with a plethora of enzymes that help both with their trafficking within tissues and the killing of pathogens. Damaged or infected organs are rapidly invaded by neutrophils. Their erroneous activation within parenchyma or the vasculature is involved in the pathogenesis of several inflammatory diseases including arthritis, colitis, sepsis, acute lung injury and liver failure...
November 10, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29083361/chondral-tissue-engineering-of-the-reumatoid-knee-with-collagen-matrix-autologous-chondrocytes-implant
#14
Massimiliano Leigheb, Michela Bosetti, Antonio De Consoli, Alessia Borroni, Mario Cannas, Federico Grassi
Articular cartilage repair is still a challenge. To date evidence is insufficient to support a treatment over the others. Inflammatory conditions in the joint hamper the application of tissue engineering during chronic joint diseases. Most of the Matrix Autologous Chondrocyte Implantation (MACI) cases reported in literature do not deal with rheumatoid knees and do not have a long clinical-histologic follow-up. We report about a 46-year old woman who suffered of a painful focal Outerbridge 4th degree chondral lesion in the medial femoral condyle of her left rheumatoid knee...
October 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29067846/origins-of-fibroblasts-in-rheumatoid-synovial-tissues-implications-from-organ-fibrotic-models
#15
Yusuke Matsuo, Tetsuya Saito, Akio Yamamoto, Hitoshi Kohsaka
Fibroblasts play crucial roles in the pathogenesis of rheumatoid arthritis (RA). Accumulation of fibroblasts in the synovial tissues characterizes the pathology of RA. Understanding how fibroblasts accumulate could lead to discovery of new therapeutic targets in RA treatment, while current antirheumatic therapies still have problems in efficacy and safety. In this regard, several studies have revealed cellular origins of fibroblasts in fibrotic tissues in murine models of organ fibrosis. Some studies employed lineage tracing, which bring generally convincing results, using transgenic mice...
October 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29035932/extracellular-vesicles-in-cartilage-homeostasis-and-osteoarthritis
#16
Shigeru Miyaki, Martin K Lotz
PURPOSE OF REVIEW: Extracellular vesicles carry bioactive molecules that can be transferred between cells and tissues. The purpose of this review is to describe how extracellular vesicles regulate functions of cells in cartilage and other joint tissues. The potential application of extracellular vesicles in the treatment of osteoarthritis and as biomarkers will also be discussed. RECENT FINDINGS: Extracellular vesicles are found in synovial fluid, in articular cartilage and in the supernatants of synoviocytes and chondrocytes...
October 13, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29027570/are-we-right-to-consider-mesenchymal-stem-cells-to-be-a-new-perspective-for-patients-with-juvenile-idiopathic-arthritis
#17
REVIEW
Krzysztof Orczyk, Elzbieta Smolewska
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood. Up to 50% of patients are resistant to standard therapy, which includes non-steroid anti-inflammatory drugs, corticosteroids, disease-modifying anti-rheumatic drugs and biologic therapies. Intra-articular injection of mesenchymal stem cells (MSCs) is proposed as a new approach to JIA treatment. MSCs can modulate inflammation via mechanisms of both adaptive and innate immune response. They are able to inhibit T and B cell proliferation, promote regulatory T cells, suppress the maturation of dendritic cells, stimulate macrophage differentiation into M2 phenotype and reduce effectiveness of natural killer cells...
October 13, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28972432/interleukin-34-promotes-fibrocyte-proliferation
#18
Carole L Galligan, Eleanor N Fish
Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting multiple joints. It remains unclear which factors in the circulation are associated with the systemic spread of the disease. Fibrocytes are pluripotent mesenchymal stem cells present in the circulation of RA patients. Our earlier findings implicated activated fibrocytes in the etiology of onset and pathogenesis of RA. Elevated levels of interleukin-34 (IL-34) in the serum and synovial fluid of RA patients are associated with rheumatoid factor and anticyclic citrullinated peptide antibodies, indicators of RA...
October 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28965939/impaired-intracellular-pathogen-clearance-and-inflammatory-joint-disease-is-whipple-s-disease-a-guiding-light
#19
Jean-Marie Berthelot, Xavier Puéchal
Whipple's disease can mimic spondyloarthritis (SpA) or rheumatoid arthritis (RA) for many years and, in a few cases, induces the development of antibodies to cyclic citrullinated peptides. The causative agent Tropheryma whipplei can smolder within cells, including macrophages, by suppressing the xenophagic process, a type of selective autophagy that targets pathogens. Other inflammatory joint diseases may also stem from impaired xenophagy with persistence of bacteria or viruses that can eventually migrate from the mucous membranes to the joints and entheses, where they may exert adverse effects on immune responses, even if they fail to replicate...
September 28, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28962889/a-new-clerodane-furano-diterpene-glycoside-from-tinospora-cordifolia-triggers-autophagy-and-apoptosis-in-hct-116-colon-cancer-cells
#20
Neha Sharma, Ashok Kumar, P R Sharma, Arem Qayum, Shashank K Singh, Prabhu Dutt, Satya Paul, Vivek Gupta, M K Verma, N K Satti, R Vishwakarma
ETHNOPHARMACOLOGICAL RELEVANCE: Tinospora cordifolia is a miraculous ayurvedic herb used in the treatment of innumerable diseases such as diabetes, gonorrhea, secondary syphilis, anaemia, rheumatoid arthritis, dermatological diseases, cancer, gout, jaundice, asthma, leprosy, in the treatment of bone fractures, liver & intestinal disorders, purifies the blood, gives new life to the whole body; (rejuvenating herb) and many more. Recent studies have revealed the anticancer potential of this plant but not much work has been done on the anticancer chemical constituents actually responsible for its amazing anticancer effects...
September 27, 2017: Journal of Ethnopharmacology
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