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Xiao Li, Wei-Wei Hu, Li Wang, Xiang-Hui Yang
BACKGROUND: Oral squamous cell carcinoma is a malignant tumor which is particularly common in the developing world, mostly in older males. OBJECTIVE: Although gene expression analyses had been performed previously, to our best knowledge, systemic co-expression analysis for this disease is still lacking to date. METHODS: In this study, we built the co-expression modules with the help of Weighted Correlation Network Analysis (WGCNA) and investigated the function enrichment of co-expression genes from important modules by bioinformatics analysis...
June 6, 2018: Cancer Biomarkers: Section A of Disease Markers
Maryam Shamsayei, Yadollah Yamini, Hamid Asiabi
In this work, the bio-nanohybrids of magnesium-aluminum layered double hydroxide intercalated with zwitterionic histidine (His-LDH) was synthesized. The crystal phase, morphology, and nanostructure of the as-prepared His-LDH were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and nitrogen adsorption-desorption methods. The His-LDHs were used to remove anionic dyes, including Congo red (CR), indigo carmine (IC) and sunset yellow FCF (SY) from aqueous solutions...
June 13, 2018: Journal of Colloid and Interface Science
Christopher Ma, Bram D van Rhijn, Vipul Jairath, Tran M Nguyen, Claire E Parker, Seema S Aceves, Glenn T Furuta, Sandeep K Gupta, David A Katzka, Ekaterina Safroneeva, Alain M Schoepfer, Alex Straumann, Jonathan M Spergel, Rish K Pai, Brian G Feagan, Ikuo Hirano, Evan S Dellon, Albert J Bredenoord
BACKGROUND & AIMS: Agents are being developed for treatment of eosinophilic esophagitis (EoE). However, it is not clear what outcome measures would best determine the efficacy and safety of these agents in clinical trials. We performed a systematic review of outcomes used in randomized placebo-controlled trials of EoE and we estimate the placebo response and rates of remission. METHODS: We searched MEDLINE, Embase, CENTRAL,, and the EU Clinical Trials Register from inception through February 20, 2018 for randomized controlled trials of pharmacologic therapies for EoE...
June 13, 2018: Clinical Gastroenterology and Hepatology
Jan Dick, Daniel E Orenstein, Jennifer M Holzer, Christoph Wohner, Anne-Laure Achard, Christopher Andrews, Noa Avriel-Avni, Pedro Beja, Nadège Blond, Javier Cabello, Chiling Chen, Ricardo Díaz-Delgado, Georgios V Giannakis, Simone Gingrich, Zita Izakovicova, Kinga Krauze, Nicolas Lamouroux, Stefan Leca, Viesturs Melecis, Kertész Miklós, Maria Mimikou, Georg Niedrist, Christophe Piscart, Carmen Postolache, Alexander Psomas, Margarida Santos-Reis, Ulrike Tappeiner, Kristin Vanderbilt, Gunther Van Ryckegem
With an overarching goal of addressing global and regional sustainability challenges, Long Term Socio-Ecological Research Platforms (LTSER) aim to conduct place-based research, to collect and synthesize both environmental and socio-economic data, and to involve a broader stakeholder pool to set the research agenda. To date there have been few studies examining the output from LTSER platforms. In this study we enquire if the socio-ecological research from 25 self-selected LTSER platforms of the International Long-Term Ecological Research (ILTER) network has produced research products which fulfil the aims and ambitions of the paradigm shift from ecological to socio-ecological research envisaged at the turn of the century...
May 1, 2018: Science of the Total Environment
Benqiang Tang, Tao Ji, Wei Guo, Xiaodong Tang, Long Jin, Sen Dong, Lu Xie
Previous series presented the timing between embolization and surgery in a wide range on the basis of their experience rather than supportive data. And comparative studies were limited to small samples. In addition, there is no study publishing the timing by considering both safety and efficacy of embolization. The aim of this study was to determine the better timing (the same day or the next day) between embolization and surgery for hypervascular spinal tumors by assessing the safety and efficacy of embolization...
June 2018: Medicine (Baltimore)
Filip Matovinović, Filip Bacan, Elvira Kereković, Alan Pegan, Ivan Rašić, Andro Košec
PURPOSE: Tonsillectomy is one of the most common surgical procedures in otorhinolaryngology. Modern general anesthetic techniques have reduced surgical risks, but performing the procedure under local anesthesia may still offer significant benefit for both the patient and surgeon. This study analyzed the risks and benefits of performing tonsillectomies under local anesthesia. METHODS: This is a retrospective longitudinal cohort study analyzing postoperative bleeding rates as a primary outcome measure...
May 26, 2018: American Journal of Otolaryngology
T Kawahara, N Hanzawa, M Sugiyama
Lactobacillus strains, a major group of lactic acid bacteria, are representative food microorganisms that have many potential beneficial effects via their interactions with immune and intestinal epithelial cells. However, little is known about the effect of Lactobacillus strains on atopic dermatitis via keratinocytes, which comprise the physical barrier of the skin. In this study, we report that Lactobacillus strains have a significant suppressive effect on tumour necrosis factor (TNF)-α-induced expression and production of thymus and activation-regulated chemokine (TARC), a T helper 2 cell chemokine responsible for atopic dermatitis, in human keratinocytes...
May 25, 2018: Beneficial Microbes
Baoping Lu, Xuna Yuan, Yuehong Ren, Qinghua Shi, Song Wang, Jinlong Dong, Ze-Dong Nan
We describe a facile method to synthesize a new type of catalyst by electrodepositing Ag nanocrystals (AgNCs) on the different polymer dyes, Poly (methylene blue) (PMB) or Poly (4-(2-Pyridylazo)-Resorcinol) (PAR) modified graphene‑carbon spheres (GS) hybrids. The self-assembled GS take dual advantages of carbon spheres and graphene. Carbon spheres acts as nano-spacers prevent the aggregation of graphene and guarantee the fast electron transfer of GS. Secondly, polymerized dyes used here are beneficial for AgNCs growing as a linker...
May 3, 2018: Bioelectrochemistry
Glorianne Pullicino, Philip Sciortino, Sean Francalanza, Paul Sciortino, Richard Pullicino
INTRODUCTION: Due to demographic changes, growing demands, technological developments and rising healthcare costs, analysis of resources in rural and urban primary care clinics is crucial. However, data on primary care provision in rural and suburban areas are lacking. Moreover, health inequities in small island communities tend to be reduced by social homogeneity and an almost indiscernible urban-rural difference. The aim of the study was to examine the urban-suburban differences in the indications for lumbosacral spine radiographs in a public primary healthcare centre in Malta...
April 2018: Rural and Remote Health
Wei-Qi Wei, Xiaohui Li, Qiping Feng, Michiaki Kubo, Iftikhar J Kullo, Peggy L Peissig, Elizabeth W Karlson, Gail P Jarvik, Ming Ta Michael Lee, Ning Shang, Eric A Larson, Todd Edwards, Christian Shaffer, Jonathan D Mosley, Shiro Maeda, Momoko Horikoshi, Marylyn Ritchie, Marc S Williams, Eric B Larson, David R Crosslin, Sarah T Bland, Jennifer A Pacheco, Laura J Rasmussen-Torvik, David Cronkite, George Hripcsak, Nancy J Cox, Russell A Wilke, C Michael Stein, Jerome I Rotter, Yukihide Momozawa, Dan M Roden, Ronald M Krauss, Joshua C Denny
Background -Coronary heart disease (CHD) is a leading cause of death globally. Although therapy with HMG-CoA reductase inhibitors (statins) decreases circulating levels of low-density lipoprotein cholesterol (LDL-C) and the incidence of CHD, additional events occur despite statin therapy in some individuals. The genetic determinants of this residual cardiovascular risk remain unknown. Methods -We performed a two-stage genome-wide association study (GWAS) of CHD events during statin therapy. We first identified 3,099 cases who experienced CHD events (defined as acute myocardial infarction or the need for coronary revascularization) during statin therapy and 7,681 controls without CHD events during comparable intensity and duration of statin therapy from four sites in the Electronic Medical Records and Genomics (eMERGE) Network...
April 27, 2018: Circulation
He Sun, Meng-Tao Xu, Xiao-Qi Wang, Meng-Hu Wang, Bao-Heng Wang, Feng-Zhe Wang, Shi-Nong Pan
Background: Magnetic resonance (MR) imaging provides a unique, noninvasive diagnostic platform to quantify the physiological and biochemical variables of skeletal muscle at rest. This study was to investigate the difference in thigh skeletal muscles between snowboarding halfpipe athletes and healthy volunteers via multiparametric MR imaging. Methods: A comparative study was conducted between 12 healthy volunteers and 14 snowboarding halfpipe athletes. MR scanning targeted the left leg at the level of the proximal thigh on a 3...
May 5, 2018: Chinese Medical Journal
Jesse T Young, Ed Heffernan, Rohan Borschmann, James R P Ogloff, Matthew J Spittal, Fiona G Kouyoumdjian, David B Preen, Amanda Butler, Lisa Brophy, Julia Crilly, Stuart A Kinner
BACKGROUND: People with mental illness and substance use disorder are over-represented in prisons. Injury-related mortality is elevated in people released from prison, and both mental illness and substance use disorder are risk factors for injury. Effective care coordination during the transition between criminal justice and community service providers improves health outcomes for people released from prison. However, the health outcomes and support needs of people with dual diagnosis (co-occurring mental illness and substance use disorder) released from prison are poorly understood...
May 2018: Lancet. Public Health
Hossein Ansari, Abbas Doosti, Mohammad Kargar, Mahdi Bijanzadeh, Mojtaba Jaafarinia
Antibiotic resistant features of Acinetobacter baumannii is partly due to the decreased outer membrane proteins (OMPs) permeability. The OmpA is one of the most conserved proteins among A. baumannii with a considerable antigenic potential to stimulate the multidimensional immune system responses. The present study was aimed to clone the ompA gene into the eukaryotic expression vector with potential as DNA vaccine. The ompA gene of A. baumannii was amplified using polymerase chain reaction (PCR). The target DNA was cloned and sub-cloned into the pTZ57R/T and pBudCE4...
June 2018: Indian Journal of Microbiology
Zhihong Wang, Chirag M Vyas, Olivia Van Benschoten, Matt A Nehs, Francis D Moore, Ellen Marqusee, Jeffrey F Krane, Matthew I Kim, Howard T Heller, Atul A Gawande, Mary C Frates, Peter M Doubilet, Gerard M Doherty, Nancy L Cho, Edmund S Cibas, Carol B Benson, Justine A Barletta, Ann Marie Zavacki, P Reed Larsen, Erik K Alexander, Trevor E Angell
BACKGROUND: In older patients, thyroid nodules are frequently detected and referred for evaluation, though usually prove to be benign disease or low-risk cancer. Therefore, management should be guided not solely by malignancy risk, but also by the relative risks of any intervention. Unfortunately, few such data are available for patients ≥70 years old. METHODS: All consecutive patients ≥70 years old assessed by ultrasound (US) and fine-needle aspiration (FNA) between 1995 and 2015 were analyzed...
April 2018: Thyroid: Official Journal of the American Thyroid Association
Liang Dai, Xiaozheng Kang, Wanpu Yan, Yongbo Yang, Peiliang Zhao, Hao Fu, Haitao Zhou, Zhen Liang, Hongchao Xiong, Yao Lin, Keneng Chen
BACKGROUND: Thoracoscopic surgery has gradually become the major procedure for lung cancer surgery in our department. Its characteristics are minimal trauma and quick recovery, which make approximately 90% of patients discharge from the hospital after surgery. However, the postoperative complications still happen now and then. We analyzed the patients who had been hospitalized for longer than 7 days after thoracoscopic lung cancer surgery, aiming to summarize the types and risk factors of complications, and improve postoperative safety of patients...
March 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Roni A Neff, Danielle Edwards, Anne Palmer, Rebecca Ramsing, Allison Righter, Julia Wolfson
OBJECTIVE: Excess meat consumption, particularly of red and processed meats, is associated with nutritional and environmental health harms. While only a small portion of the population is vegetarian, surveys suggest many Americans may be reducing their meat consumption. To inform education campaigns, more information is needed about attitudes, perceptions, behaviours and foods eaten in meatless meals. DESIGN: A web-based survey administered in April 2015 assessed meat reduction behaviours, attitudes, what respondents ate in meatless meals and sociodemographic characteristics...
March 26, 2018: Public Health Nutrition
He Chen, Jiacheng Yao, Yusi Fu, Yuhong Pang, Jianbin Wang, Yanyi Huang
The next generation sequencing (NGS) technologies have been rapidly evolved and applied to various research fields, but they often suffer from losing long-range information due to short library size and read length. Here, we develop a simple, cost-efficient, and versatile NGS library preparation method, called tagmentation on microbeads (TOM). This method is capable of recovering long-range information through tagmentation mediated by microbead-immobilized transposomes. Using transposomes with DNA barcodes to identically label adjacent sequences during tagmentation, we can restore inter-read connection of each fragment from original DNA molecule by fragment-barcode linkage after sequencing...
April 11, 2018: ACS Applied Materials & Interfaces
Danyael Lutgens, Ridha Joober, Srividya Iyer, Martin Lepage, Ross Norman, Norbert Schmitz, Sally Mustafa, Sherezad Abadi, Ashok Malla
BACKGROUND: Specialized early intervention (EI) following a first episode of psychosis (FEP) are effective at reducing negative symptoms, although its trajectory warrants systematic assessment. However, findings are equivocal as to whether extended gains are made post 2 years of EI and whether there is additional benefit of extending EI for an additional 3 years. METHODS: Data on 178 FEP patients, from a randomized controlled trial of a 3-year extension of EI service v...
March 14, 2018: Psychological Medicine
Hyunchul Kim, Woon Ih Choi, Yoonjung Jang, Mahalingam Balasubramanian, Wontae Lee, Gwi Ok Park, Su Bin Park, Jaeseung Yoo, Jin Seok Hong, Youn-Suk Choi, Hyo Sug Lee, In Tae Bae, Ji Man Kim, Won-Sub Yoon
Current lithium ion battery technology is tied in with conventional reaction mechanisms such as insertion, conversion, and alloying reactions even though most future applications like EVs demand much higher energy densities than current ones. Exploring the exceptional reaction mechanism and related electrode materials can be critical for pushing current battery technology to a next level. Here, we introduce an exceptional reaction with a Co(OH)2 material which exhibits an initial charge capacity of 1112 mAh g-1 , about twice its theoretical value based on known conventional conversion reaction, and retains its first cycle capacity after 30 cycles...
March 27, 2018: ACS Nano
A Olveira, L Domínguez, J Troya, A Arias, F Pulido, P Ryan, L M Benítez, J González-García, M L Montes
Guidelines recommend evaluating persistent alteration of liver tests in HCV-infected patients after sustained virological response (SVR) and its influence on liver disease progression. We studied the prevalence, etiology, associated factors and evolutionary implications of persistent alteration of liver tests in HCV patients after direct-acting antivirals (DAA)-induced SVR. This was a prospective study of HCV-infected patients and SVR after DAA. Those with another previously diagnosed liver disease were excluded...
February 24, 2018: Journal of Viral Hepatitis
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