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https://www.readbyqxmd.com/read/29217413/apolipoprotein-e-containing-high-density-lipoprotein-hdl-modifies-the-impact-of-cholesterol-overloaded-hdl-on-incident-coronary-heart-disease-risk-a-community-based-cohort-study
#1
Yue Qi, Jing Liu, Wei Wang, Miao Wang, Fan Zhao, Jiayi Sun, Jun Liu, Dong Zhao
BACKGROUND: Experimental studies have shown that cholesterol-overloaded high-density lipoprotein (HDL) can promote the formation of apolipoprotein E (APOE)-containing HDL, a process correcting the atherogenic function of cholesterol-overloaded HDL. OBJECTIVE: The objective of the study was to explore whether APOE-containing HDL can attenuate the defective impact of cholesterol-overloaded HDL on the development of coronary heart disease (CHD) in humans. METHODS: We measured APOE-HDL cholesterol (APOE-HDLC), HDL cholesterol (HDLC), and HDL particle number in 1112 participants aged 45 to 74 years at baseline in a community-based cohort study...
November 14, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29205039/comparison-of-two-static-in-vitro-digestion-methods-for-screening-bioaccessibility-of-carotenoids-in-fruits-vegetables-and-animal-products
#2
Daniele Bobrowski Rodrigues, Chureeporn Chitchumroonchokchai, Lilian Regina Barros Mariutti, Adriana Zerlotti Mercadante, Mark L Failla
In vitro digestion methods are routinely used to assess the bioaccessibility of carotenoids and other dietary lipophilic compounds. Here, we compared the recovery of carotenoids and their efficiency of micellarization in digested fruits, vegetables, egg yolk, salmon and mixed vegetable salad with and without the animal products using the static INFOGEST method (Maniekus et al. Food Funct. 2014, 5, 1113-1124) and the procedure of Failla et al. (Food Funct. 2014, 5, 1101-1112) modified to simulate conditions for the fed state...
December 5, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29203182/the-generation-of-a-simian-adenoviral-vectored-hcv-vaccine-encoding-genetically-conserved-gene-segments-to-target-multiple-hcv-genotypes
#3
Annette von Delft, Timothy A Donnison, José Lourenço, Claire Hutchings, Caitlin E Mullarkey, Anthony Brown, Oliver G Pybus, Paul Klenerman, Senthil Chinnakannan, Eleanor Barnes
BACKGROUND: Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural infection. However, corresponding viral regions are highly variable at a population level, with a reduction in T-cell reactivity to these variants. We therefore designed and manufactured second generation simian adenovirus vaccines encoding genomic segments, conserved between viral genotypes and assessed these for immunogenicity...
December 1, 2017: Vaccine
https://www.readbyqxmd.com/read/29193603/quality-of-life-in-adolescents-with-hepatitis-c-treated-with-sofosbuvir-and-ribavirin
#4
Zobair M Younossi, Maria Stepanova, Kathleen B Schwarz, Stefan Wirth, Philip Rosenthal, Regino Gonzalez-Peralta, Karen Murray, Linda Henry, Sharon Hunt
Chronic HCV infection has been associated with impairment of health-related quality of life (HRQL) in both adults and pediatric patients. Our aim was to assess the HRQL of HCV-positive children treated with SOF+RBV. The data for this post-hoc analysis was collected in a phase 2 open-label multinational study that evaluated safety and efficacy of sofosbuvir (400mg/day) plus ribavirin (weight-based up to 1400mg/day) for 12 or 24 weeks in adolescents with chronic HCV (GS-US-334-1112). Patients and their parents/guardians completed the PedsQL-4...
November 28, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29159541/automated-detection-of-exudative-age-related-macular-degeneration-in-spectral-domain-optical-coherence-tomography-using-deep-learning
#5
Maximilian Treder, Jost Lennart Lauermann, Nicole Eter
PURPOSE: Our purpose was to use deep learning for the automated detection of age-related macular degeneration (AMD) in spectral domain optical coherence tomography (SD-OCT). METHODS: A total of 1112 cross-section SD-OCT images of patients with exudative AMD and a healthy control group were used for this study. In the first step, an open-source multi-layer deep convolutional neural network (DCNN), which was pretrained with 1.2 million images from ImageNet, was trained and validated with 1012 cross-section SD-OCT scans (AMD: 701; healthy: 311)...
November 20, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29141059/a-retrospective-study-on-efficacy-of-pulsed-dye-laser-and-intense-pulsed-light-for-the-treatment-of-facial-telangiectasia
#6
Lin Gao, Ni Gao, Wenting Song, Erle Dang, Rong Yin, Li Wang, Gang Wang
<p>Both pulsed dye laser (PDL) and intense pulsed light (IPL) systems have been demonstrated to be effective for treatment of facial telangiectasia, however there have been very few comparative studies between both treatments involving purely Asian patient populations. In this study, we performed a retrospective analysis to compare the efficacy of PDL and IPL systems for the treatment of facial telangiectasia. A total of 416 patients with facial telangiectasia who were treated by PDL or IPLs in our department from August 2012 to March 2015 were included in this study...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29133276/de-novo-assembly-and-annotation-of-the-whole-genomic-analysis-of-vibrio-campbellii-rt-1-strain-from-infected-shrimp-litopenaeus-vannamei
#7
R Thirugnanasambandam, D Inbakandan, L Stanley Abraham, C Kumar, S M Sundaram, B Subashni, R Vasantharaja, A Arul Anantha Kumar, R Kirubagaran, S Ajmal Khan, T Balasubramanian
OBJECTIVES: This study aimed to sequence the whole genome of Vibrio campbellii RT-1 strain. METHODS: V. campbellii strain was isolated from an infected shrimp, Litopenaeus vannamei collected from aquaculture ponds, India (12.1899° N, 79.9249° E). The whole genome sequencing (WGS) was performed using the Illumina Hiseq 2500 platform and assembled de novo using SPAdes and Velvet optimiser. Furthermore, the gene prediction and annotation were performed by a rapid prokaryotic genome tool-Prokka...
November 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29129465/developing-a-model-for-measuring-fear-of-pain-in-norwegian-samples-the-fear-of-pain-questionnaire-norway
#8
Sara M Vambheim, Peter Solvoll Lyby, Per M Aslaksen, Magne Arve Flaten, Ole Åsli, Espen Bjørkedal, Laila M Martinussen
BACKGROUND: Fear of pain is highly correlated with pain report and physiological measures of arousal when pain is inflicted. The Fear of Pain Questionnaire III (FPQ-III) and The Fear of Pain Questionnaire Short Form (FPQ-SF) are self-report inventories developed for assessment of fear of pain (FOP). A previous study assessed the fit of the FPQ-III and the FPQ-SF in a Norwegian non-clinical sample and proved poor fit of both models. This inspired the idea of testing the possibility of a Norwegian FOP-model...
November 9, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29119738/physiological-characterization-transcriptomic-profiling-and-microsatellite-marker-mining-of-lycium-ruthenicum
#9
Jin-Huan Chen, Dong-Zhi Zhang, Chong Zhang, Mei-Long Xu, Wei-Lun Yin
Lycium ruthenicum is a perennial shrub species that has attracted considerable interest in recent years owing to its nutritional value and ability to thrive in a harsh environment. However, only extremely limited transcriptomic and genomic data related to this species can be found in public databases, thereby limiting breeding research and molecular function analysis. In this study, we characterized the physiological and biochemical responses to saline-alkaline mixed stress by measuring photochemical efficiency, chlorophyll content, and protective enzyme activity...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29108488/validation-of-three-scoring-risk-stratification-models-for-thyroid-nodules
#10
Su Min Ha, Hye Shin Ahn, Jung Hwan Baek, Hwa Young Ahn, Yun Jae Chung, Bo Youn Cho, Sung Bin Park
BACKGROUND: To minimize potential harm from overuse of fine-needle aspiration, Thyroid Imaging Reporting and Data Systems (TIRADSs) were developed for thyroid nodule risk stratification. The purpose of this study was to perform validation of three scoring risk stratification models for thyroid nodules using ultrasonography features, a web-based malignancy risk stratification system at website (http://www.gap.pe.kr/thyroidnodule.php) and those developed by the Korean Society of Thyroid Radiology (KSThR) and the American College of Radiology (ACR)...
November 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29106917/variation-in-prophylactic-antibiotic-use-for-laparoscopic-cholecystectomy-need-for-better-stewardship-in-pediatric-surgery
#11
Kibileri Williams, Lauren Baumann, Fizan Abdullah, Shawn D St Peter, Tolulope A Oyetunji
PURPOSE: The role of prophylactic antibiotics for elective laparoscopic cholecystectomy has been questioned over the last decade. Although gradually being discontinued in the adult population, the practice among pediatric surgeons remains unknown. Our aim was to investigate the use of perioperative antibiotics in children undergoing elective laparoscopic cholecystectomy (LC) for symptomatic cholelithiasis and biliary dyskinesia. METHODS: We retrospectively reviewed the Pediatric Health Information System (PHIS) database for 2015 and selected all patients 18years old or younger who underwent LC for cholelithiasis (without cholecystitis) or biliary dyskinesia...
October 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29063738/cardiovascular-outcomes-of-pregnancy-in-marfan-s-syndrome-patients-a-literature-review
#12
REVIEW
So Yeon Kim, Diana S Wolfe, Cynthia C Taub
AIMS: Pregnancy in patients with Marfan's syndrome (MFS) carries an increased risk of cardiovascular complications, resulting in increased maternal and fetal mortality and morbidity. Literature on MFS pregnant patients is relatively sparse, and there has yet to be a concrete consensus on the management of this unique patient population. The purpose of our paper is to provide a literature review of case reports and studies on MFS during pregnancy (published between 2005 and 2015) and to explore cardiovascular outcomes of patients with MFS...
October 23, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/29017744/effect-of-season-on-follicular-population-quality-and-nuclear-maturation-of-bovine-oocytes-under-tropical-conditions
#13
Jorge Alonso Peralta-Torres, Jesús Ricardo Aké-López, José Candelario Segura-Correa, Jesús Ricardo Aké-Villanueva
The aim was to determine the effect of season of the year and the presence of a corpus luteum (CL) on follicular population (FP) and the quality of the oocytes, and of season on nuclear maturation of the bovine oocytes under tropical conditions. Three seasons were evaluated: hot-dry (March-June), hot-humid (July-October) and fresh-humid (November-February). In a first study, 1112 bovine ovaries were obtained from a local slaughterhouse. Follicles were classified as small (≤4mm), middle (4.1-8mm) and large (≥8...
October 5, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28984100/perioperative-ultrasound-applied-to-diagnosis-and-decision-making-in-anesthesia
#14
Nuno T Ferreira Albuquerque Costa, Carmen Gomar Sancho
INTRODUCTION: Ultrasound is a portable and safe technology that is increasingly used to assist anesthetic procedures and has been integrated into the routine practice of a wide range of invasive procedures. As a complementary diagnostic tool, publications related to perioperative support other than vascular access and nerve blocks are currently lacking. EVIDENCE ACQUISITION: Given the growing interest of anesthesiologists in acquisition of knowledge and skills of ultrasound, we propose a systematic review of the diagnosis, decision making or change in perioperative management of non-cardiac surgical patients derived from ultrasound practice...
October 4, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28953156/review-of-implementation-science-a-neglected-opportunity-to-accelerate-improvements-in-the-safety-and-quality-of-surgical-care-by-hull-l-athanasiou-t-russ-s-in-ann-surg-265-1104-1112-2016
#15
Kelly P Schultz, Larry H Hollier
No abstract text is available yet for this article.
September 25, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28952831/perception-of-breakfast-ingestion-enhances-high-intensity-cycling-performance
#16
Stephen A Mears, Kathryn Dickinson, Kurt Bergin-Taylor, Reagan Dee, Jack Kay, Lewis J James
PURPOSE: To examine the effect on short duration, high intensity cycling time trial performance when a semi-solid breakfast containing carbohydrate or a taste and texture matched placebo is ingested 90 minutes pre-exercise compared to a water control. METHODS: Thirteen well trained cyclists (25 ± 8 years, 71.1 ± 5.9 kg, 1.76 ± 0.04 m, 383 ± 46 Wmax, VO2peak 4.42 ± 0.53 L·min(-1)) performed three experimental trials examining breakfast ingestion 90 minutes before a 10 minute steady state cycle (60% Wmax) and a ~20 minute time trial (to complete a workload target of 376 ± 36 kJ)...
September 27, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28951183/revision-rate-of-misplaced-pedicle-screws-of-the-thoracolumbar-spine-comparison-of-3d-fluoroscopy-navigated-with-freehand-placement-a-systematic-analysis-and-review-of-the-literature
#17
Jens Fichtner, Nicole Hofmann, Anna Rienmüller, Niels Buchmann, Jens Gempt, Jan S Kirschke, Florian Ringel, Bernhard Meyer, Yu-Mi Ryang
BACKGROUND: Recent studies could show higher accuracy rates of image-guided pedicle screw placement compared to freehand placement. However, data focusing on the impact of spinal navigation on the rate of revision surgeries due to misplaced pedicle screws (PS) are scarce. OBJECTIVE: This study is aimed at identifying the rate of revision surgeries for misplaced PS comparing 3D fluoroscopic navigation (3DFL) to freehand (FH) PS placement. METHODS: A retrospective analysis of a total of 2232 patients (mean age 65...
September 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28951180/impact-of-symptomatic-metastatic-spinal-cord-compression-on-survival-of-patients-with-non-small-cell-lung-cancer
#18
Gustavo Telles da Silva, Anke Bergmann, Luiz Claudio Santos Thuler
OBJECTIVES: Non-small cell lung cancer (NSCLC) is one of the most common primary tumor site among patients with metastatic spinal cord compression (MSCC). This disorder is related to neurological dysfunction and can reduce the quality of life, but the association between MSCC and death is unclear. The aim of this study was to analyse the impact of the occurrence of symptomatic MSCC on overall survival (OS) of patients with NSCLC. MATERIAL AND METHODS: A cohort study was carried out involving 1112 patients with NSCLC who were enrolled between 2006 and 2014 in a single cancer center...
September 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28938889/intoxication-with-ghb-gbl-characteristics-and-trends-from-ambulance-attended-overdoses
#19
Desiree Madah-Amiri, Lars Myrmel, Guttorm Brattebø
BACKGROUND: Overdoses from so-called "club drugs" (GHB/GBL) have become a more frequent cause of overdoses attended by ambulance services. Given its availability, affordability, and lack of awareness of risks, there is a common misconception among users that the drug is relatively safe. METHODS: This study reviewed ambulance records in Bergen, Norway between 2009 and 2015 for cases of acute poisonings, particularly from suspected GHB/GBL intoxication. RESULTS: In total, 1112 cases of GHB and GBL poisoning were identified...
September 22, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28881667/a-high-plasma-d-dimer-level-predicts-poor-prognosis-in-gynecological-tumors-in-east-asia-area-a-systematic-review-and-meta-analysis
#20
Lei Xu, Fan He, Hongcai Wang, Bei Gao, Huini Wu, Shuping Zhao
High pre-treatment plasma D-dimer levels have been reported as a factor associated with a poor prognosis in different types of malignancies, including pancreatic, gastric, colorectal, lung, and nasopharyngeal carcinoma. Here, we performed a meta-analysis to determine the association of plasma D-dimer levels and long term survival in gynecological cancers, including ovarian, cervical and endometrial carcinoma. We searched all eligible publications in PubMed and Web of Science Databases up to August 2016. Primary outcomes, including overall survival (OS), disease-free survival and hazard ratios (HR) of were extracted and analyzed...
August 1, 2017: Oncotarget
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