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https://www.readbyqxmd.com/read/28505290/supraphysiologic-estradiol-is-an-independent-predictor-of-low-birth-weight-in-full-term-singletons-born-after-fresh-embryo-transfer
#1
N Pereira, R T Elias, P J Christos, A C Petrini, K Hancock, J P Lekovich, Z Rosenwaks
STUDY QUESTION: Is supraphysiologic estradiol (E2) an independent predictor of low birth weight (LBW) in singletons born after fresh IVF-embryo transfer (ET) cycles? SUMMARY ANSWER: Our results suggest that E2 > 2500 pg/ml is an independent predictor for LBW in full-term singletons born to normal responder patients undergoing fresh IVF-ET cycles. WHAT IS KNOWN ALREADY: The pathogenesis of LBW in IVF singletons remains unknown. However, recent studies have suggested that the hyperestrogenic milieu generated during ovarian stimulation may create a sub-optimal peri-implantation environment, leading to placental dysfunction, and therefore, LBW...
May 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28497564/no-significant-enrichment-of-rare-functionally-defective-cpa1-variants-in-a-large-chinese-idiopathic-chronic-pancreatitis-cohort
#2
Hao Wu, Dai-Zhan Zhou, Dorottya Berki, Andrea Geisz, Wen-Bin Zou, Xiao-Tian Sun, Liang-Hao Hu, Zhen-Hua Zhao, An-Jing Zhao, Lin He, David N Cooper, Claude Férec, Jian-Min Chen, Zhao-Shen Li, Miklós Sahin-Tóth, Zhuan Liao
Rare functionally defective carboxypeptidase A1 (CPA1) variants have been reported to predispose to nonalcoholic chronic pancreatitis, mainly the idiopathic subtype. However, independent replication has so far been lacking, particularly in Asian cohorts where initial studies employed small sample sizes. Herein we performed targeted next-generation sequencing of the CPA1 gene in 1112 Han Chinese idiopathic chronic pancreatitis (ICP) patients - the largest ICP cohort so far analyzed in a single population - and 1580 controls...
May 12, 2017: Human Mutation
https://www.readbyqxmd.com/read/28456510/high-acuity-sleeve-gastrectomy-patients-in-a-free-standing-ambulatory-surgical-center
#3
Peter Billing, Josiah Billing, Jedediah Kaufman, Kurt Stewart, Eric Harris, Rob Landerholm
BACKGROUND: Procedures performed in ambulatory surgical centers (ASC) can provide several advantages over hospital-based surgery. Understandably, concerns have been raised regarding "high acuity" cases in the ASC setting. Recently the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) presented protocols for ASCs to follow, requiring them to perform only "low acuity" cases to be compliant with accreditation. OBJECTIVE: Assess the safety and efficacy of outpatient sleeve gastrectomy (SG) on the "high acuity patient" in a free-standing ASC...
March 27, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28450139/3d-fully-convolutional-networks-for-subcortical-segmentation-in-mri-a-large-scale-study
#4
REVIEW
Jose Dolz, Christian Desrosiers, Ismail Ben Ayed
This study investigates a 3D and fully convolutional neural network (CNN) for subcortical brain structure segmentation in MRI. 3D CNN architectures have been generally avoided due to their computational and memory requirements during inference. We address the problem via small kernels, allowing deeper architectures. We further model both local and global context by embedding intermediate-layer outputs in the final prediction, which encourages consistency between features extracted at different scales and embeds fine-grained information directly in the segmentation process...
April 24, 2017: NeuroImage
https://www.readbyqxmd.com/read/28425233/comparison-of-the-standard-gnrh-antagonist-protocol-and-the-luteal-phase-estradiol-gnrh-antagonist-priming-protocol-in-poor-ovarian-responders
#5
Mehmet Fırat Mutlu, İlknur Mutlu, Mehmet Erdem, İsmail Güler, Ahmet Erdem
BACKGROUND/AIM: The aim of the study was to compare the luteal estradiol patch/GnRH antagonists priming protocol (LPP) with the standard GnRH antagonist protocol in poor ovarian responders (PORs) in terms of the outcomes of in vitro fertilization (IVF) treatment. MATERIALS AND METHODS: IVF outcomes of 265 cycles in 265 patients (106 in the LPP group, 159 in the standard GnRH antagonist group) were evaluated retrospectively. RESULTS: Mean length of stimulation (11...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28407120/biological-versus-mechanical-bentall-procedure-for-aortic-root-replacement-a-propensity-score-analysis-of-a-consecutive-series-of-1112-patients%C3%A2
#6
Antonio Pantaleo, Giacomo Murana, Luca Di Marco, Giuliano Jafrancesco, Giuseppe Barberio, Paolo Berretta, Alessandro Leone, Roberto Di Bartolomeo, Davide Pacini
OBJECTIVES: In this study, a propensity-matching analysis was used to compare biological versus mechanical composite valve graft implantation for early mortality and morbidities and for late complications including the need for aortic reintervention. METHODS: Between 1978 and 2011, 1112 consecutive patients underwent a complete aortic root replacement using either a biological Bentall (BB, n  = 356) or a mechanical Bentall (MB, n  = 756) valve conduit. Preoperative data were stratified according to the type of valve graft, and treatment bias was addressed by propensity score analysis...
April 11, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28396619/the-complete-mitogenome-of-orcula-dolium-draparnaud-1801-ultra-deep-sequencing-from-a-single-long-range-pcr-using-the-ion-torrent-pgm
#7
D S J Groenenberg, J Harl, E Duijm, E Gittenberger
BACKGROUND: With the increasing capacity of present-day next-generation sequencers the field of mitogenomics is rapidly changing. Enrichment of the mitochondrial fraction, is no longer necessary for obtaining mitogenomic data. Despite the benefits, shotgun sequencing approaches also have disadvantages. They do not guarantee obtaining the complete mitogenome, generally require larger amounts of input DNA and coverage is low compared to sequencing with enrichment strategies. If the mitogenome could be amplified in a single amplification, additional time and costs for sample preparation might outweigh these disadvantages...
2017: Hereditas
https://www.readbyqxmd.com/read/28386748/open-and-endovascular-elective-treatment-of-abdominal-aortic-aneurysms-a-real-world-experience
#8
Daniela Mazzaccaro, Giovanni Nano, Alberto M Settembrini, Michele Carmo, Raffaello Dallatana, Simone Salvati, Giovanni Malacrida, Piergiorgio G Settembrini
PURPOSE: To present a real-world experience of the elective treatment of abdominal aortic aneurysms (AAAs) using both open repair (OR) and endovascular repair (EVAR). METHODS: Data from patients treated consecutively between January 1, 2000 and December 31, 2014 were collected retrospectively and reviewed. The primary outcomes were 30-day mortality and complication rates, freedom from reintervention, and survival in the long-term. RESULTS: We analyzed data on 1112 patients (660 EVAR, 452 OR)...
April 6, 2017: Surgery Today
https://www.readbyqxmd.com/read/28385120/are-routine-preoperative-liver-function-tests-in-patients-with-uncomplicated-symptomatic-gallstone-disease-necessary
#9
Marijke van den Berg, Gijs M van Couwelaar, Christel A L de Raaff, Sjoerd M Lagarde, Pieter Joosse, Bart A van Wagensveld, Bart C Vrouenraets
BACKGROUND: The aim of this study was to evaluate the value of preoperative liver function tests (LFTs) in patients with uncomplicated gallstone disease and scheduled for laparoscopic cholecystectomy. METHODS: All 1112 patients who underwent a laparoscopic cholecystectomy for symptomatic gallstone disease during a 6-year cohort were retrospectively reviewed. Only patients who presented with uncomplicated disease were selected. Preoperative LFTs, pre-, and postoperative endoscopic retrograde cholangio pancreaticographies (ERCPs) and postoperative complications were collected...
April 7, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28368326/mineral-and-anti-nutritional-contents-of-niger-seed-guizotia-abyssinica-l-f-cass-linseed-linumusitatissimum-l-and-sesame-sesamumindicum-l-varieties-grown-in-ethiopia
#10
Tesfaye Deme, Gulelat D Haki, Nigussie Retta, Ashagrie Woldegiorgis, Mulatu Geleta
Oilseeds are rich sources of micronutrients and contribute to combating malnutrition caused by micronutrient deficiency. The objective of this study was to investigate the mineral and anti-nutritional contents of different varieties of niger seed, linseed and sesame. Five niger seed, eight linseed and ten sesame varieties were used. Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) was used for mineral analysis and the standard method was adopted to estimate tannin and phytate. Twelve mineral elements; Ca, K, Mg, Na, P, B, Cu, Fe, Mn, S, Se and Zn were analyzed for each oilseed variety...
April 1, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28361913/multi-scale-radiomic-analysis-of-sub-cortical-regions-in-mri-related-to-autism-gender-and-age
#11
Ahmad Chaddad, Christian Desrosiers, Matthew Toews
We propose using multi-scale image textures to investigate links between neuroanatomical regions and clinical variables in MRI. Texture features are derived at multiple scales of resolution based on the Laplacian-of-Gaussian (LoG) filter. Three quantifier functions (Average, Standard Deviation and Entropy) are used to summarize texture statistics within standard, automatically segmented neuroanatomical regions. Significance tests are performed to identify regional texture differences between ASD vs. TDC and male vs...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28339460/evaluating-implementation-of-a-fire-prevention-injury-prevention-briefing-in-children-s-centres-cluster-randomised-controlled-trial
#12
Toity Deave, Adrian Hawkins, Arun Kumar, Mike Hayes, Nicola Cooper, Michael Watson, Joanne Ablewhite, Carol Coupland, Alex Sutton, Gosia Majsak-Newman, Lisa McDaid, Trudy Goodenough, Kate Beckett, Elaine McColl, Richard Reading, Denise Kendrick
BACKGROUND: Many developed countries have high mortality rates for fire-related deaths in children aged 0-14 years with steep social gradients. Evidence-based interventions to promote fire safety practices exist, but the impact of implementing a range of these interventions in children's services has not been assessed. We developed an Injury Prevention Briefing (IPB), which brought together evidence about effective fire safety interventions and good practice in delivering interventions; plus training and facilitation to support its use and evaluated its implementation...
2017: PloS One
https://www.readbyqxmd.com/read/28327424/cellulase-assisted-extraction-of-polysaccharides-from-malva-sylvestris-process-optimization-and-potential-functionalities
#13
Hosein Rostami, Seyed Mohammad Taghi Gharibzahedi
Enzyme-assisted extraction process of the water-soluble Malva sylvestris polysaccharides (MSPs) was optimized using response surface methodology (RSM). The highest yield (10.40%) of MSPs was achieved at 5.64% cellulase, 55.65°C temperature, 3.4h time, and 5.22 pH. Three homogeneous polysaccharide fractions (MSP-1, MSP-2, MSP-3) were purified by DEAE-cellulose and Sephadex G-100 chromatography, which were composed of galactose, glucuronic acid, arabinose, rhamnose and mannose in different molar ratios with molecular weight range of 2...
March 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28299289/occurrence-of-nematodes-of-the-genus-anisakis-in-mediterranean-and-atlantic-fish-marketed-in-sardinia
#14
Daniele Casti, Christian Scarano, Maria Cristina Piras, Paolo Merella, Sonia Muglia, Francesca Piras, Giovanni Garippa, Carlo Spanu, Enrico Pietro Luigi De Santis
Anisakiasis is a gastrointestinal fish-borne zoonosis caused by the ingestion of third stage larvae of the genus Anisakis. Between January and December 2013, 1112 specimens of four commercial fish species (Engraulis encrasicolus, Merluccius merluccius, Scomber colias and Trachurus mediterraneus) marketed in Sardinia (Italy) were examined for Anisakis sp. The overall prevalence of Anisakis spp larvae was 39.9%, all morphologically identified as Type I. Scomber colias showed the highest prevalence (100%), followed by M...
January 24, 2017: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/28291247/enhancing-studies-of-the-connectome-in-autism-using-the-autism-brain-imaging-data-exchange-ii
#15
Adriana Di Martino, David O'Connor, Bosi Chen, Kaat Alaerts, Jeffrey S Anderson, Michal Assaf, Joshua H Balsters, Leslie Baxter, Anita Beggiato, Sylvie Bernaerts, Laura M E Blanken, Susan Y Bookheimer, B Blair Braden, Lisa Byrge, F Xavier Castellanos, Mirella Dapretto, Richard Delorme, Damien A Fair, Inna Fishman, Jacqueline Fitzgerald, Louise Gallagher, R Joanne Jao Keehn, Daniel P Kennedy, Janet E Lainhart, Beatriz Luna, Stewart H Mostofsky, Ralph-Axel Müller, Mary Beth Nebel, Joel T Nigg, Kirsten O'Hearn, Marjorie Solomon, Roberto Toro, Chandan J Vaidya, Nicole Wenderoth, Tonya White, R Cameron Craddock, Catherine Lord, Bennett Leventhal, Michael P Milham
The second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance the scope of brain connectomics research in Autism Spectrum Disorder (ASD). Consistent with the initial ABIDE effort (ABIDE I), that released 1112 datasets in 2012, this new multisite open-data resource is an aggregate of resting state functional magnetic resonance imaging (MRI) and corresponding structural MRI and phenotypic datasets. ABIDE II includes datasets from an additional 487 individuals with ASD and 557 controls previously collected across 16 international institutions...
March 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28277894/the-influence-of-comorbidities-on-the-aging-males-symptoms-scale-in-patients-with-erectile-dysfunction
#16
Jorge Panach-Navarrete, José María Martínez-Jabaloyas
OBJECTIVES: To investigate if certain common age-related comorbidities are related with a positive aging males' symptoms (AMS) test outcome. METHODS: This was a multicentric, transversal, observational study carried out in a male population with erectile dysfunction. Comorbidities and testosterone levels were registered. The relationship between comorbidities, testosterone levels, and the AMS test outcomes was studied using the global score and the sub-scale score components...
March 9, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28263239/early-and-delayed-evaluation-of-solid-tumours-with-64cu-atsm-pet-ct-a-pilot-study-on-semiquantitative-and-computer-aided-fractal-geometry-analysis
#17
Egesta Lopci, Fabio Grizzi, Carlo Russo, Luca Toschi, Ilaria Grassi, Gianfranco Cicoria, Filippo Lodi, Sandro Mattioli, Stefano Fanti
OBJECTIVE: The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses. PATIENTS AND METHODS: Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with Cu-ATSM PET/CT. Participants received an intravenous injection of Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT...
April 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28235751/online-dissemination-strategies-of-a-canada-research-chair-overview-and-lessons-learned
#18
Jessica Hébert, Hubert Robitaille, Stéphane Turcotte, France Légaré
BACKGROUND: Little is known about the use of online dissemination strategies, such as websites and social media, to increase the visibility and uptake of research. OBJECTIVE: To describe two online dissemination strategies of the Canada Research Chair in Implementation of Shared Decision Making in Primary Care over an eight-year period. METHODS: Our two sources of online dissemination data were the website of the Canada Research Chair in Implementation of Shared Decision Making in Primary Care and the Chair's Twitter account...
February 24, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28213723/differences-in-orgasm-frequency-among-gay-lesbian-bisexual-and-heterosexual-men-and-women-in-a-u-s-national-sample
#19
David A Frederick, H Kate St John, Justin R Garcia, Elisabeth A Lloyd
There is a notable gap between heterosexual men and women in frequency of orgasm during sex. Little is known, however, about sexual orientation differences in orgasm frequency. We examined how over 30 different traits or behaviors were associated with frequency of orgasm when sexually intimate during the past month. We analyzed a large US sample of adults (N = 52,588) who identified as heterosexual men (n = 26,032), gay men (n = 452), bisexual men (n = 550), lesbian women (n = 340), bisexual women (n = 1112), and heterosexual women (n = 24,102)...
February 17, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28188612/hepatitis-b-immunoglobulin-during-pregnancy-for-prevention-of-mother-to-child-transmission-of-hepatitis-b-virus
#20
REVIEW
Ahizechukwu C Eke, George U Eleje, Uzoamaka A Eke, Yun Xia, Jiao Liu
BACKGROUND: Hepatitis is a viral infection of the liver. It is mainly transmitted between people through contact with infected blood, frequently from mother to baby in-utero. Hepatitis B poses significant risk to the fetus and up to 85% of infants infected by their mothers at birth develop chronic hepatitis B virus (HBV) infection. Hepatitis B immunoglobulin (HBIG) is a purified solution of human immunoglobulin that could be administered to the mother, newborn, or both. HBIG offers protection against HBV infection when administered to pregnant women who test positive for hepatitis B envelope antigen (HBeAg) or hepatitis B surface antigen (HBsAg), or both...
February 11, 2017: Cochrane Database of Systematic Reviews
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