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https://www.readbyqxmd.com/read/28213723/differences-in-orgasm-frequency-among-gay-lesbian-bisexual-and-heterosexual-men-and-women-in-a-u-s-national-sample
#1
David A Frederick, H Kate St John, Justin R Garcia, Elisabeth A Lloyd
There is a notable gap between heterosexual men and women in frequency of orgasm during sex. Little is known, however, about sexual orientation differences in orgasm frequency. We examined how over 30 different traits or behaviors were associated with frequency of orgasm when sexually intimate during the past month. We analyzed a large US sample of adults (N = 52,588) who identified as heterosexual men (n = 26,032), gay men (n = 452), bisexual men (n = 550), lesbian women (n = 340), bisexual women (n = 1112), and heterosexual women (n = 24,102)...
February 17, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28188612/hepatitis-b-immunoglobulin-during-pregnancy-for-prevention-of-mother-to-child-transmission-of-hepatitis-b-virus
#2
REVIEW
Ahizechukwu C Eke, George U Eleje, Uzoamaka A Eke, Yun Xia, Jiao Liu
BACKGROUND: Hepatitis is a viral infection of the liver. It is mainly transmitted between people through contact with infected blood, frequently from mother to baby in-utero. Hepatitis B poses significant risk to the fetus and up to 85% of infants infected by their mothers at birth develop chronic hepatitis B virus (HBV) infection. Hepatitis B immunoglobulin (HBIG) is a purified solution of human immunoglobulin that could be administered to the mother, newborn, or both. HBIG offers protection against HBV infection when administered to pregnant women who test positive for hepatitis B envelope antigen (HBeAg) or hepatitis B surface antigen (HBsAg), or both...
February 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28131529/impact-of-body-mass-index-and-operative-approach-on-surgical-morbidity-and-costs-in-women-with-endometrial-carcinoma-and-hyperplasia
#3
Rudy S Suidan, Weiguo He, Charlotte C Sun, Hui Zhao, Nicole D Fleming, Pedro T Ramirez, Pamela T Soliman, Shannon N Westin, Karen H Lu, Sharon H Giordano, Larissa A Meyer
OBJECTIVE: To assess the impact of body mass index (BMI) and operative approach on surgical morbidity and costs in patients with endometrial carcinoma (EC) and hyperplasia (EH). METHODS: All women with BMI data who underwent surgery for EC or EH from 2008 to 2014 were identified from MarketScan, a healthcare claims database. Differences in 30-day complications and costs were compared between BMI groups and stratified by surgical modality. RESULTS: Of 1112 patients, 35%, 36%, and 29% had a BMI of ≤29, 30-39, and ≥40kg/m(2), respectively...
January 25, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28128360/discovery-of-cancer-driver-long-noncoding-rnas-across-1112-tumour-genomes-new-candidates-and-distinguishing-features
#4
Andrés Lanzós, Joana Carlevaro-Fita, Loris Mularoni, Ferran Reverter, Emilio Palumbo, Roderic Guigó, Rory Johnson
Long noncoding RNAs (lncRNAs) represent a vast unexplored genetic space that may hold missing drivers of tumourigenesis, but few such "driver lncRNAs" are known. Until now, they have been discovered through changes in expression, leading to problems in distinguishing between causative roles and passenger effects. We here present a different approach for driver lncRNA discovery using mutational patterns in tumour DNA. Our pipeline, ExInAtor, identifies genes with excess load of somatic single nucleotide variants (SNVs) across panels of tumour genomes...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096288/mid-regional-pro-atrial-natriuretic-peptide-to-predict-clinical-course-in-heart-failure-patients-undergoing-cardiac-resynchronization-therapy
#5
Mattia Arrigo, Quynh A Truong, Jackie Szymonifka, Mercedes Rivas-Lasarte, Heli Tolppanen, Malha Sadoune, Etienne Gayat, Alain Cohen-Solal, Frank Ruschitzka, James L Januzzi, Jagmeet P Singh, Alexandre Mebazaa
AIMS: Cardiac resynchronization therapy (CRT) induces reverse cardiac remodelling in heart failure (HF), but many patients receiving CRT remain non-responders. This study assessed the role of amino-terminal-pro-B-type natriuretic peptide (NT-proBNP), mid-regional-pro-atrial natriuretic peptide (MR-proANP), and mid-regional-pro-adrenomedullin (MR-proADM) at the time of device implantation to predict favourable clinical course (CRT response and/or risk of MACE) in HF patients receiving CRT...
January 16, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28086882/differential-effects-of-glucagon-like-peptide-1-receptor-agonists-on-heart-rate
#6
REVIEW
Martin Lorenz, Francesca Lawson, David Owens, Denis Raccah, Christine Roy-Duval, Anne Lehmann, Riccardo Perfetti, Lawrence Blonde
While glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are known to increase heart rate (HR), it is insufficiently recognized that the extent varies greatly between the various agonists and is affected by the assessment methods employed. Here we review published data from 24-h time-averaged HR monitoring in healthy individuals and subjects with type 2 diabetes mellitus (T2DM) treated with either short-acting GLP-1 RAs, lixisenatide or exenatide, or long-acting GLP-1 RAs, exenatide LAR, liraglutide, albiglutide, or dulaglutide (N = 1112; active-treatment arms)...
January 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28069319/effect-of-ulinastatin-combined-with-thymosin-alpha1-on-sepsis-a-systematic-review-and-meta-analysis-of-chinese-and-indian-patients
#7
REVIEW
Dadong Liu, Zongying Yu, Jiangtao Yin, Yikun Chen, Hao Zhang, Fan Xin, Haiyan Fu, Bing Wan
PURPOSE: To assess the effects of urinary trypsin inhibitor (UTI) ulinastatin combined with thymosin alpha1 (Tα1) on sepsis. MATERIALS AND METHODS: The meta-analysis included 8 randomized controlled trials (N=1112 patients) on UTI-based therapy for sepsis published before July 10, 2016. Two investigators independently extracted data and assessed the quality of each study. The short-term mortality rate, duration of mechanical ventilator and vasopressor use, length of intensive care unit stay, Acute Physiology and Chronic Health Evaluation (APACHE) II score, and differences in inflammatory cytokines (interleukin [IL]-6, IL-10, and tumor necrosis factor α) were assessed using statistical software...
December 27, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/28048318/we-h-brc-06-a-unified-machine-learning-based-probabilistic-model-for-automated-anomaly-detection-in-the-treatment-plan-data
#8
X Chang, A Kalet, S Liu, D Yang
PURPOSE: The purpose of this work was to investigate the ability of a machine-learning based probabilistic approach to detect radiotherapy treatment plan anomalies given initial disease classes information. METHODS: In total we obtained 1112 unique treatment plans with five plan parameters and disease information from a Mosaiq treatment management system database for use in the study. The plan parameters include prescription dose, fractions, fields, modality and techniques...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047646/su-f-t-606-monte-carlo-evaluation-of-tissue-inhomogeneity-corrections-in-the-treatment-of-liver-cancer-patients-using-stereotactic-body-radiotherapy
#9
D Pokhrel, S Sood, R Badkul, C McClinton, H Jiang, H Saleh, C Lominska
PURPOSE: To evaluate the dosimetric performance of X-ray Voxel Monte Carlo(XVMC) algorithm in effort to clinically validate Monte Carlo-approach in heterogeneous liver phantom and liver SBRT plans. METHODS: An anthropomorphic RPC liver phantom incorporating a liver structure with two cylindrical targets and organs-at-risk (OARs) was used in phantom validation. Subsequently, five patients with metastatic liver cancer were treated using heterogeneity-corrected pencil-beam(PB-hete)algorithm were analyzed following RTOG-1112 criteria ...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28035219/the-role-of-polymorphism-of-interleukin-2-10-13-and-tnf-%C3%AE-genes-in-cutaneous-t-cell-lymphoma-pathogenesis
#10
Boguslaw Nedoszytko, Berenika Olszewska, Jadwiga Roszkiewicz, Jolanta Glen, Monika Zabłotna, Hanna Ługowska-Umer, Roman Nowicki, Małgorzata Sokołowska-Wojdyło
INTRODUCTION: As the pathogenesis of cutaneous T-cell lymphomas (CTCL) is not fully understood, inherited gene polymorphisms are considered to play a role in the development of lymphomas. AIM: To investigate whether certain gene polymorphisms might be involved in the development of CTCL. MATERIAL AND METHODS: In the case-control study we compared the frequency of nine selected single nucleotide polymorphisms (SNP) of seven genes (rs1800587/-889 C/T of interleukin (IL)-1α, rs2069762/-330G/T) and rs2069763/+166G/T of IL-2, rs1800925/-1112 C/T of IL-13, rs1800896/-1082 A/G of IL-10, rs4073/-251 A/T of IL-8, rs5370/K198N, rs180054/-1370T/G of endothelin-1 and rs1800629/-308 G/A of TNF-α) in 43 CTCL and Polish cases using the amplification refractory mutation system polymerase chain reaction method...
December 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28013111/risk-of-rectal-cancer-after-colectomy-for-patients-with-ulcerative-colitis-a-national-cohort-study
#11
Maie Abdalla, Kalle Landerholm, Peter Andersson, Roland E Andersson, Pär Myrelid
BACKGROUND & AIMS: Patients with ulcerative colitis (UC) have an increased risk of rectal cancer, so reconstruction with an ileal pouch anal anastomosis (IPAA) is generally preferred to an ileo-rectal anastomosis (IRA) after subtotal colectomy. Similarly, completion proctectomy is recommended for patients with ileostomy and diverted rectum, although this approach has been questioned because anti-inflammatory agents might reduce cancer risk. We performed a national cohort study in Sweden to assess the risk of rectal cancer in patients with UC who have an IRA, IPAA, or diverted rectum after subtotal colectomy...
December 21, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27998870/-expressions-of-inflammatory-cytokines-in-intestinal-mucosa-and-their-prognostic-value-in-patients-with-ulcerative-colitis
#12
An-Na Lin, Yu-Qing Li, Mu-Xiao Zhong, Jiang Liu, Qian Dai, Wei Zhu, Ya-Li Zhang
OBJECTIVE: To detect the expressions of IL-17, IL-23, IL-22 and IL-11 in the intestinal mucosa of patients with ulcerative colitis (UC) and analyze their prognostic values. METHODS: Forty patients with active UC, 15 with UC in remission and 15 healthy subjects were examined for the expressions and distribution of IL-17, IL-23, IL-22, and IL-11 in the colorectal mucosausing immunohistochemistry. We further collected the data from 40 patients with routine therapy and regular follow-up and compared the expressions of those cytokines according to the condition of mucosal healing...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27996964/multi-echo-fmri-replication-sample-of-autobiographical-memory-prospection-and-theory-of-mind-reasoning-tasks
#13
Elizabeth DuPre, Wen-Ming Luh, R Nathan Spreng
The default network is involved in self-generated thought, a class of cognition that includes autobiographical memory, prospection, and reasoning about the mental states of others. We collected a replication sample of Spreng and Grady (J Cogn. Neurosci. 22, 1112-1123, 2010), confirming that the default network differentially supports each of these forms of self-generated thought. Here we describe this dataset of multi-echo fMRI data in 31 young adults during autobiographical remembering, imagining, and mentalizing; we also provide an additional resting-state scan for each subject...
December 20, 2016: Scientific Data
https://www.readbyqxmd.com/read/27979109/determination-of-iron-iii-in-food-biological-and-environmental-samples
#14
Chitra Verma, Kavita Tapadia, Anupam Bala Soni
The nanodrop spectrophotometric (NDS) determination of iron (III) in water samples has been established. The proposed method is simple, selective and highly sensitive. The extraction of Fe (III)-thiocyanate complex was done by novel organic reagents such as N-phenylacetamide, N-alkylacetamide, (alkyl=butyl, hexyl and octyl group) in chloroform. The Fe (III) extract was examined in the strong acidic (HCl+H2SO4) solution. The maximum value of molar absorptivity was found to be 1.8×10(5)Lmol(-1)cm(-1) at λmax, 477nm (⩾9 fold enrichments) for N-octylacetamide (N-OAA)...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27968822/expenditure-and-financial-burden-for-common-cancers-in-china-a-hospital-based-multicentre-cross-sectional-study
#15
Hui-Yao Huang, Ju-Fang Shi, Lan-Wei Guo, Xin-Yu Zhu, Le Wang, Xian-Zhen Liao, Guo-Xiang Liu, Ya-Na Bai, A-Yan Mao, Jian-Song Ren, Xiao-Jie Sun, Kai Zhang, Jie He, Min Dai
BACKGROUND: Comprehensive health economic evaluation, a key component of the Cancer Screening Program in Urban China (CanSPUC), was expected to support government policy-making on screening initiatives for common cancers (lung, breast, colorectal, oesophageal, liver, and stomach cancer) in urban China. Estimation of expenditure for cancer diagnosis and treatment from a societal perspective was an essential component. The aim of this study was to estimate direct medical and non-medical expenditure and to discern the resultant financial burden...
October 2016: Lancet
https://www.readbyqxmd.com/read/27911352/medical-equipment-antiseptic-processes-using-the-atmospheric-plasma-sprayed-copper-coatings
#16
M Goudarzi, Sh Saviz, M Ghoranneviss, A Salar Elahi
Antibacterial surfaces such as copper coatings are able to reduce the growth of bacteria. In this study, copper coatings was deposited on the 316 stainless steel substrates by a handmade device operating as an atmospheric plasma spraying system. The chemical composition microstructure and morphology surface of the coatings are examined by x-ray diffraction (XRD) and scanning electron microscope (SEM) and back scattering electron microscope (BSE). Micro hardness as one of the key properties of the coating is characterized based on cross-section...
November 30, 2016: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/27858326/left-ventricular-assist-devices-impact-hospital-resource-utilization-without-affecting-patient-mortality-in-gastrointestinal-bleeding
#17
Feng Li, Alice Hinton, Alan Chen, Nishaki K Mehta, Samer Eldika, Cheng Zhang, Hisham Hussan, Darwin L Conwell, Somashekar G Krishna
BACKGROUND: Left ventricular assist devices (LVADs) are being utilized for management of end-stage heart failure and require systemic anticoagulation. Gastrointestinal bleeding (GIB) is one of the most common adverse events following LVAD implantation. AIM: To investigate the impact of continuous-flow (CF) LVAD implants on outcomes of patients admitted with GIB. METHODS: This is a cross-sectional study utilizing the Nationwide Inpatient Sample in the CF-LVAD era from 2010 to 2012...
November 17, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27850749/1112-apache-ii-score-and-at-iii-activity-on-admission-relates-to-mortality-in-icu-patients
#18
Noriko Saito, Ayumi Kawasaki, Ahmin Kim, Rui Komatsu, Noboru Akiduki, Mizuho Namiki, Munekazu Takeda, Arino Yaguchi
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847279/sofosbuvir-and-velpatasvir-combination-improves-outcomes-reported-by-patients-with-hcv-infection-without-or-with-compensated-or-decompensated-cirrhosis
#19
Zobair M Younossi, Maria Stepanova, Jordon Feld, Stefan Zeuzem, Mark Sulkowski, Graham R Foster, Alessandra Mangia, Michael Charlton, Jacqueline G O'Leary, Michael P Curry, Fatema Nader, Linda Henry, Sharon Hunt
BACKGROUND & AIMS: The combination of sofosbuvir and velpatasvir is used to treat patients with hepatitis C virus (HCV) infection of different genotypes. We compared the effects of this treatment regimen, with and without ribavirin, on outcomes reported by patients (patient-reported outcomes [PROs]) with HCV infection, with or without cirrhosis. METHODS: We performed a post hoc analysis of data collected from phase 3 clinical trials (ASTRAL-1, -2, -3, and -4) of 1701 patients infected with HCV of different genotypes treated with sofosbuvir and velpatasvir with ribavirin for 12 weeks (n = 87), sofosbuvir with ribavirin for 12 or 24 weeks (n = 401), and ribavirin-free sofosbuvir and velpatasvir for 12 or 24 weeks (n = 1213)...
November 12, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27836829/one-year-outcome-after-descemet-membrane-endothelial-keratoplasty-dmek-comparing-sulfur-hexafluoride-sf6-20-versus-100-air-for-anterior-chamber-tamponade
#20
Friederike Schaub, Philip Enders, Katharina Snijders, Silvia Schrittenlocher, Sebastian Siebelmann, Ludwig M Heindl, Björn O Bachmann, Claus Cursiefen
PURPOSE: To investigate 1-year clinical outcome and complication rates following Descemet membrane endothelial keratoplasty (DMEK) with sulfur hexafluoride 20% (SF620%) anterior chamber tamponade compared with conventionally used 100% air for primary graft attachment during DMEK surgery. METHODS: Records of 1112 consecutive DMEKs were reviewed retrospectively and grouped by anterior chamber tamponade used during DMEK surgery (SF620% vs 100% air). Outcome measures included intraocular pressure (IOP), best spectacle-corrected visual acuity (BSCVA), endothelial cell density (ECD) and central corneal thickness (CCT) at 1, 3, 6 and 12 months after DMEK surgery...
November 11, 2016: British Journal of Ophthalmology
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