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https://www.readbyqxmd.com/read/29420599/comorbidity-disability-and-healthcare-expenditure-of-ankylosing-spondylitis-in-korea-a-population-based-study
#1
Jeong Seok Lee, Baek-Lok Oh, Hee Young Lee, Yeong Wook Song, Eun Young Lee
BACKGROUND: Ankylosing spondylitis (AS) is an inflammatory rheumatic disease typically diagnosed in young age and follows a chronic progressive course. Its impact on the patient is life-long and the burden that AS exerts on society is increasing cumulatively every year. We aimed to quantify the burden of AS and to identify the factors associated with comorbidity, disability, and healthcare expenditure in Korean AS patients. METHODS: We conducted a nationwide, population-based study using health insurance data (2003-2013)...
2018: PloS One
https://www.readbyqxmd.com/read/29415708/il-13-1112-polymorphism-and-periodontitis-susceptibility-a-meta-analysis
#2
Wenbo Zhang, Pu Xu, Zhuogeng Chen, Yanan Cheng, Xiaoni Li, Qiuhua Mao
BACKGROUND: Several studies have examined the association between the IL-13 -1112C/T polymorphism and the risk of periodontitis. However, these studies have reached different conclusions. The aim of the current study was to investigate the link between this IL-13 -1112 polymorphism and susceptibility to periodontitis. METHODS: We utilized electronic databases, including the CNKI (China National Knowledge Infrastructure), Wanfang, PubMed, Embase, and Cochrane Library databases, to manually search for relevant research published through November 30, 2016...
February 7, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29391570/flexible-spectral-manipulation-property-of-a-high-power-linearly-polarized-random-fiber-laser
#3
Jun Ye, Jiangming Xu, Jiaxin Song, Hanshuo Wu, Hanwei Zhang, Jian Wu, Pu Zhou
Fiber lasers with flexible spectral manipulation property could provide a flexible tool for scenes where the temporal coherence property accounts, for example, coherent sensing/communication and nonlinear frequency conversion. Due to the good laser performance and relative simplicity of implementation, random fiber lasers (RFLs) based on random distributed feedback and Raman gain have earned more and more attention in the past few years, and a variety of RFLs with substantially different spectral properties have been developed...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29368189/multi-center-prospective-survey-of-inflammatory-bowel-diseases-in-kerala-more-than-2000-cases
#4
Mathew Philip, Philip Augustine, Varghese Thomas, G N Ramesh, K R Vinayakumar, T M Ramachandran, Ismail Siyad, Roy J Mukkada, R Sobhana Devi, Antony P Chettupuzha, Varghese A Jaison, M Ramesh, P Mahadevan, Abraham Koshy
BACKGROUND: Inflammatory bowel disease (IBD) is considered uncommon in Asia. The aim of this study was to document the demographic characteristics and clinical aspects of ulcerative colitis (UC) and Crohn's disease (CD) in Kerala, India. METHODS: A survey of IBD in Kerala was performed. All gastroenterologists in the region were invited. From May 2013 to October 2015, data were collected in a standardized pro-forma. RESULTS: Forty-seven doctors in 34 centers contributed data...
January 24, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29366861/functional-network-analysis-reveals-biological-roles-of-lncrnas-and-mrnas-in-mog35-55-specific-cd4-t-helper-cells
#5
Zhaoying Li, Pixia Gong, Wen Wang, Siying Qu, Xi Wang, Zhongze He, Guangyou Wang, Qingfei Kong, Lili Mu, Jinghua Wang, Shaohong Fang, Wei Zhao, Bo Sun, Hulun Li
Long non-coding RNAs have the potential to regulate immune responses. Their impact on multiple sclerosis has remained elusive. For illustrating their roles in experimental autoimmune encephalomyelitis (EAE) pathogenesis, we investigated the differential expression of lncRNAs and mRNAs in CD4+Th cells obtained from myelin oligodendrocytic glycoprotein35-55(MOG35-55)-induced EAE and complete Freund's adjuvant (CFA) controls. We observed differential expression of 1112 lncRNAs and 519 mRNAs in CD4+Th cells. The functional network showed lncRNAs had the capacity to modulate EAE pathogenesis via regulating many known EAE regulators such as Ptpn6...
January 20, 2018: Genomics
https://www.readbyqxmd.com/read/29306244/tnf-alpha-863c-a-promoter-and-tnfrii-196t-g-exonic-variationsmay-be-risk-factors-for-juvenile-idiopathic-arthritis
#6
Bahadır Batar, Sezen Özman, Kenan Barut, Özgür Kasapçopur, Mehmet Güven
Background/aim: Juvenile idiopathic arthritis (JIA) is a chronic complex autoimmune disease. Genetic and environmental factors increase the risk of JIA. It is accepted that alterations in immune system pathways play an important role in the pathogenesis of JIA. The aim of the study was to investigate the possible association between immune system regulatory gene polymorphisms and JIA in Turkish patients. Materials and methods: We analyzed eight polymorphisms, TNF-alpha-863 C > A, TNFRII 196 T > G, IL2-631 G > A, IL13-1112 C > T, CCR2 190 G > A, CCR5delta32, CTLA4-1661 A > G, and PTPN22 1858 C > T, in 76 patients with JIA and in 80 healthy controls, who were of a similar age and same sex...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29217413/apolipoprotein-e-containing-high-density-lipoprotein-hdl-modifies-the-impact-of-cholesterol-overloaded-hdl-on-incident-coronary-heart-disease-risk-a-community-based-cohort-study
#7
Yue Qi, Jing Liu, Wei Wang, Miao Wang, Fan Zhao, Jiayi Sun, Jun Liu, Dong Zhao
BACKGROUND: Experimental studies have shown that cholesterol-overloaded high-density lipoprotein (HDL) can promote the formation of apolipoprotein E (APOE)-containing HDL, a process correcting the atherogenic function of cholesterol-overloaded HDL. OBJECTIVE: The objective of the study was to explore whether APOE-containing HDL can attenuate the defective impact of cholesterol-overloaded HDL on the development of coronary heart disease (CHD) in humans. METHODS: We measured APOE-HDL cholesterol (APOE-HDLC), HDL cholesterol (HDLC), and HDL particle number in 1112 participants aged 45 to 74 years at baseline in a community-based cohort study...
November 14, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29205039/comparison-of-two-static-in-vitro-digestion-methods-for-screening-bioaccessibility-of-carotenoids-in-fruits-vegetables-and-animal-products
#8
Daniele Bobrowski Rodrigues, Chureeporn Chitchumroonchokchai, Lilian Regina Barros Mariutti, Adriana Zerlotti Mercadante, Mark L Failla
In vitro digestion methods are routinely used to assess the bioaccessibility of carotenoids and other dietary lipophilic compounds. Here, we compared the recovery of carotenoids and their efficiency of micellarization in digested fruits, vegetables, egg yolk, salmon and mixed vegetable salad with and without the animal products using the static INFOGEST method (Maniekus et al. Food Funct. 2014, 5, 1113-1124) and the procedure of Failla et al. (Food Funct. 2014, 5, 1101-1112) modified to simulate conditions for the fed state...
December 5, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29203182/the-generation-of-a-simian-adenoviral-vectored-hcv-vaccine-encoding-genetically-conserved-gene-segments-to-target-multiple-hcv-genotypes
#9
Annette von Delft, Timothy A Donnison, José Lourenço, Claire Hutchings, Caitlin E Mullarkey, Anthony Brown, Oliver G Pybus, Paul Klenerman, Senthil Chinnakannan, Eleanor Barnes
BACKGROUND: Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural infection. However, corresponding viral regions are highly variable at a population level, with a reduction in T-cell reactivity to these variants. We therefore designed and manufactured second generation simian adenovirus vaccines encoding genomic segments, conserved between viral genotypes and assessed these for immunogenicity...
December 1, 2017: Vaccine
https://www.readbyqxmd.com/read/29193603/quality-of-life-in-adolescents-with-hepatitis-c-treated-with-sofosbuvir-and-ribavirin
#10
Zobair M Younossi, Maria Stepanova, Kathleen B Schwarz, Stefan Wirth, Philip Rosenthal, Regino Gonzalez-Peralta, Karen Murray, Linda Henry, Sharon Hunt
Chronic HCV infection has been associated with impairment of health-related quality of life (HRQL) in both adults and pediatric patients. Our aim was to assess the HRQL of HCV-positive children treated with SOF+RBV. The data for this post-hoc analysis was collected in a phase 2 open-label multinational study that evaluated safety and efficacy of sofosbuvir (400mg/day) plus ribavirin (weight-based up to 1400mg/day) for 12 or 24 weeks in adolescents with chronic HCV (GS-US-334-1112). Patients and their parents/guardians completed the PedsQL-4...
November 28, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29159541/automated-detection-of-exudative-age-related-macular-degeneration-in-spectral-domain-optical-coherence-tomography-using-deep-learning
#11
Maximilian Treder, Jost Lennart Lauermann, Nicole Eter
PURPOSE: Our purpose was to use deep learning for the automated detection of age-related macular degeneration (AMD) in spectral domain optical coherence tomography (SD-OCT). METHODS: A total of 1112 cross-section SD-OCT images of patients with exudative AMD and a healthy control group were used for this study. In the first step, an open-source multi-layer deep convolutional neural network (DCNN), which was pretrained with 1.2 million images from ImageNet, was trained and validated with 1012 cross-section SD-OCT scans (AMD: 701; healthy: 311)...
November 20, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29141059/a-retrospective-study-on-efficacy-of-pulsed-dye-laser-and-intense-pulsed-light-for-the-treatment-of-facial-telangiectasia
#12
Lin Gao, Ni Gao, Wenting Song, Erle Dang, Rong Yin, Li Wang, Gang Wang
<p>Both pulsed dye laser (PDL) and intense pulsed light (IPL) systems have been demonstrated to be effective for treatment of facial telangiectasia, however there have been very few comparative studies between both treatments involving purely Asian patient populations. In this study, we performed a retrospective analysis to compare the efficacy of PDL and IPL systems for the treatment of facial telangiectasia. A total of 416 patients with facial telangiectasia who were treated by PDL or IPLs in our department from August 2012 to March 2015 were included in this study...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29133276/de-novo-assembly-and-annotation-of-the-whole-genomic-analysis-of-vibrio-campbellii-rt-1-strain-from-infected-shrimp-litopenaeus-vannamei
#13
R Thirugnanasambandam, D Inbakandan, L Stanley Abraham, C Kumar, S M Sundaram, B Subashni, R Vasantharaja, A Arul Anantha Kumar, R Kirubagaran, S Ajmal Khan, T Balasubramanian
OBJECTIVES: This study aimed to sequence the whole genome of Vibrio campbellii RT-1 strain. METHODS: V. campbellii strain was isolated from an infected shrimp, Litopenaeus vannamei collected from aquaculture ponds, India (12.1899° N, 79.9249° E). The whole genome sequencing (WGS) was performed using the Illumina Hiseq 2500 platform and assembled de novo using SPAdes and Velvet optimiser. Furthermore, the gene prediction and annotation were performed by a rapid prokaryotic genome tool-Prokka...
November 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29129465/developing-a-model-for-measuring-fear-of-pain-in-norwegian-samples-the-fear-of-pain-questionnaire-norway
#14
Sara M Vambheim, Peter Solvoll Lyby, Per M Aslaksen, Magne Arve Flaten, Ole Åsli, Espen Bjørkedal, Laila M Martinussen
BACKGROUND: Fear of pain is highly correlated with pain report and physiological measures of arousal when pain is inflicted. The Fear of Pain Questionnaire III (FPQ-III) and The Fear of Pain Questionnaire Short Form (FPQ-SF) are self-report inventories developed for assessment of fear of pain (FOP). A previous study assessed the fit of the FPQ-III and the FPQ-SF in a Norwegian non-clinical sample and proved poor fit of both models. This inspired the idea of testing the possibility of a Norwegian FOP-model...
November 9, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29119738/physiological-characterization-transcriptomic-profiling-and-microsatellite-marker-mining-of-lycium-ruthenicum
#15
Jin-Huan Chen, Dong-Zhi Zhang, Chong Zhang, Mei-Long Xu, Wei-Lun Yin
Lycium ruthenicum is a perennial shrub species that has attracted considerable interest in recent years owing to its nutritional value and ability to thrive in a harsh environment. However, only extremely limited transcriptomic and genomic data related to this species can be found in public databases, thereby limiting breeding research and molecular function analysis. In this study, we characterized the physiological and biochemical responses to saline-alkaline mixed stress by measuring photochemical efficiency, chlorophyll content, and protective enzyme activity...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29108488/validation-of-three-scoring-risk-stratification-models-for-thyroid-nodules
#16
Su Min Ha, Hye Shin Ahn, Jung Hwan Baek, Hwa Young Ahn, Yun Jae Chung, Bo Youn Cho, Sung Bin Park
BACKGROUND: To minimize potential harm from overuse of fine-needle aspiration, Thyroid Imaging Reporting and Data Systems (TIRADSs) were developed for thyroid nodule risk stratification. The purpose of this study was to perform validation of three scoring risk stratification models for thyroid nodules using ultrasonography features, a web-based malignancy risk stratification system at website (http://www.gap.pe.kr/thyroidnodule.php) and those developed by the Korean Society of Thyroid Radiology (KSThR) and the American College of Radiology (ACR)...
November 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29106917/variation-in-prophylactic-antibiotic-use-for-laparoscopic-cholecystectomy-need-for-better-stewardship-in-pediatric-surgery
#17
Kibileri Williams, Lauren Baumann, Fizan Abdullah, Shawn D St Peter, Tolulope A Oyetunji
PURPOSE: The role of prophylactic antibiotics for elective laparoscopic cholecystectomy has been questioned over the last decade. Although gradually being discontinued in the adult population, the practice among pediatric surgeons remains unknown. Our aim was to investigate the use of perioperative antibiotics in children undergoing elective laparoscopic cholecystectomy (LC) for symptomatic cholelithiasis and biliary dyskinesia. METHODS: We retrospectively reviewed the Pediatric Health Information System (PHIS) database for 2015 and selected all patients 18years old or younger who underwent LC for cholelithiasis (without cholecystitis) or biliary dyskinesia...
October 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29063738/cardiovascular-outcomes-of-pregnancy-in-marfan-s-syndrome-patients-a-literature-review
#18
REVIEW
So Yeon Kim, Diana S Wolfe, Cynthia C Taub
AIMS: Pregnancy in patients with Marfan's syndrome (MFS) carries an increased risk of cardiovascular complications, resulting in increased maternal and fetal mortality and morbidity. Literature on MFS pregnant patients is relatively sparse, and there has yet to be a concrete consensus on the management of this unique patient population. The purpose of our paper is to provide a literature review of case reports and studies on MFS during pregnancy (published between 2005 and 2015) and to explore cardiovascular outcomes of patients with MFS...
October 23, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/29017744/effect-of-season-on-follicular-population-quality-and-nuclear-maturation-of-bovine-oocytes-under-tropical-conditions
#19
Jorge Alonso Peralta-Torres, Jesús Ricardo Aké-López, José Candelario Segura-Correa, Jesús Ricardo Aké-Villanueva
The aim was to determine the effect of season of the year and the presence of a corpus luteum (CL) on follicular population (FP) and the quality of the oocytes, and of season on nuclear maturation of the bovine oocytes under tropical conditions. Three seasons were evaluated: hot-dry (March-June), hot-humid (July-October) and fresh-humid (November-February). In a first study, 1112 bovine ovaries were obtained from a local slaughterhouse. Follicles were classified as small (≤4mm), middle (4.1-8mm) and large (≥8...
October 5, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28984100/perioperative-ultrasound-applied-to-diagnosis-and-decision-making-in-anesthesia
#20
Nuno T Ferreira Albuquerque Costa, Carmen Gomar Sancho
INTRODUCTION: Ultrasound is a portable and safe technology that is increasingly used to assist anesthetic procedures and has been integrated into the routine practice of a wide range of invasive procedures. As a complementary diagnostic tool, publications related to perioperative support other than vascular access and nerve blocks are currently lacking. EVIDENCE ACQUISITION: Given the growing interest of anesthesiologists in acquisition of knowledge and skills of ultrasound, we propose a systematic review of the diagnosis, decision making or change in perioperative management of non-cardiac surgical patients derived from ultrasound practice...
January 2018: Minerva Anestesiologica
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