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Jingzhong Xie, Naxin Huo, Shenghui Zhou, Yi Wang, Guanghao Guo, Karin R Deal, Shuhong Ouyang, Yong Liang, Zhenzhong Wang, Lichan Xiao, Tingting Zhu, Tiezhu Hu, Vijay Tiwari, Jianwei Zhang, Hongxia Li, Zhongfu Ni, Yingyin Yao, Huiru Peng, Shengli Zhang, Olin D Anderson, Patrick E McGuire, Jan Dvorak, Ming-Cheng Luo, Zhiyong Liu, Yong Q Gu, Qixin Sun
Bread wheat (Triticum aestivum, AABBDD) is an allohexaploid species derived from two rounds of interspecific hybridizations. A high-quality genome sequence assembly of diploid Aegilops tauschii, the donor of the wheat D genome, will provide a useful platform to study polyploid wheat evolution. A combined approach of BAC pooling and next-generation sequencing technology was employed to sequence the minimum tiling path (MTP) of 3176 BAC clones from the short arm of Ae. tauschii chromosome 3 (At3DS). The final assembly of 135 super-scaffolds with an N50 of 4...
October 5, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
John W Pickering, Jaimi H Greenslade, Louise Cullen, Dylan Flaws, William Parsonage, Sally Aldous, Peter George, Andrew Worster, Peter A Kavsak, Martin P Than
BACKGROUND: -The European Society of Cardiology (ESC) new guidelines to rule-in and rule-out acute myocardial infarction (AMI) in the emergency department (ED) include a rapid assessment algorithm based on high-sensitivity cardiac troponin and sampling at zero and one hour. ED physicians require very high sensitivity to confidently rule-out AMI, while cardiologists aim to minimise false positive results. METHODS: -High-sensitivity troponin I (hs-cTnI) and T (hs-cTnT) assays were used to measure troponin concentrations in patients presenting with chest-pain symptoms and being investigated for possible acute coronary syndrome at hospitals in New Zealand, Australia and Canada...
October 17, 2016: Circulation
A Hennigs, F Riedel, F Marmé, P Sinn, K Lindel, A Gondos, K Smetanay, M Golatta, C Sohn, F Schuetz, J Heil, A Schneeweiss
BACKGROUND: During the last decade, neoadjuvant chemotherapy (NACT) of early breast cancer (EBC) evolved from a therapy intended to enable operability to a standard treatment option aiming for increasing cure rates equivalent to adjuvant chemotherapy (ACT). In parallel, improvements in the quality control of breast cancer care have been established in specialized breast care units. PATIENTS AND METHODS: This study analyzed chemotherapy usage in patients with EBC treated at the Heidelberg University Breast Unit between January 2003 and December 2014...
October 15, 2016: Breast Cancer Research and Treatment
Alwin van Drongelen, Cécile R L Boot, Hynek Hlobil, Tjabe Smid, Allard J van der Beek
BACKGROUND: MORE Energy is a mobile health intervention which aims to reduce fatigue and improve health in airline pilots. The primary objective of this process evaluation was to assess the reach, dose delivered, compliance, fidelity, barriers and facilitators, and satisfaction of the intervention. The second objective was to investigate the associations of adherence to the intervention with compliance and with participant satisfaction. Thirdly, we investigated differences between the subgroups within the target population...
2016: BMC Public Health
Fidele Karamage, Chi Zhang, Alphonse Kayiranga, Hua Shao, Xia Fang, Felix Ndayisaba, Lamek Nahayo, Christophe Mupenzi, Guangjin Tian
Soil erosion has become a serious problem in recent decades due to unhalted trends of unsustainable land use practices. Assessment of soil erosion is a prominent tool in planning and conservation of soil and water resource ecosystems. The Universal Soil Loss Equation (USLE) was applied to Nyabarongo River Catchment that drains about 8413.75 km² (33%) of the total Rwanda coverage and a small part of the Southern Uganda (about 64.50 km²) using Geographic Information Systems (GIS) and Remote Sensing technologies...
2016: International Journal of Environmental Research and Public Health
Koichi Kozaki, Masahiro IInuma, Tomoyuki Takagi, Takanori Fukuda, Takaya Sanpei, Yusuke Terunuma, Yoshiharu Yatabe, Kazuhiro Akano
Cell-free and concentrated ascites reinfusion therapy (CART) is expected to improve symptoms associated with refractory ascites of the decompensated liver cirrhosis patients. The aim of this study was to evaluate the safety and efficacy of the CART system performed on the decompensated liver cirrhosis patients. In this retrospective observational study, we evaluated 24 CART processes performed on 11 patients with decompensated liver cirrhosis. We evaluated the effectiveness and adverse events during CART procedures...
August 2016: Therapeutic Apheresis and Dialysis
Hideyuki Ikematsu, Naoki Kawai, Norio Iwaki, Seizaburo Kashiwagi
The duration of fever and other symptoms as markers of the clinical effectiveness of laninamivir octanoate hydrate (laninamivir) were investigated in the Japanese 2014-2015 influenza season and the results were compared with those of the previous three seasons, 2011-2012 to 2013-2014. From these four seasons, the data of 636 influenza A(H3N2) and 128 influenza B patients was available for analysis. No significant difference was found in their baseline characteristics. The median duration of fever for all A(H3N2) patients ranged from 32...
September 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Mark P Hehir, Adam Mackie, Michael S Robson
OBJECTIVE: To examine the outcomes of vaginal birth after cesarean (VBAC) in women, in spontaneous labor, delivering after 37 weeks' gestation at an institution where trial of labor after a previous cesarean delivery (TOLAC) is encouraged and management of labor is standardized. METHODS: This retrospective cohort study included 3071 women with one previous cesarean only and no vaginal delivery who underwent a trial of labor from 2001 to 2011. Women were managed using the standardized "active management of labor" intrapartum protocol...
August 23, 2016: Journal of Maternal-fetal & Neonatal Medicine
Preeti Patel, Avineesh Singh, Vijay Patel, Deepak K Jain, Ravichandran Veerasamy, Harish Rajak
Histone deacetylase inhibitors (HDACIs) can reactivate gene expression and inhibit the growth and survival of cancer cells. The 3D-QSAR and Pharmacophore modeling studies were performed to identify important pharmacophoric features and correlate 3D-chemical structure with biological activity. The pharmacophore hypotheses were developed using e-pharmacophore script and phase module. Pharmacophore hypothesis represents the 3D arrangement of molecular features necessary for activity. A series of 55 compounds with well-assigned HDAC inhibitory activity was used for 3D-QSAR model development...
August 1, 2016: Combinatorial Chemistry & High Throughput Screening
Caroline Wehmeier, Argyrios Georgalis, Patricia Hirt-Minkowski, Patrizia Amico, Gideon Hoenger, Thomas Voegele, Nicole Brun, Andreas Bock, Thomas Wolff, Lorenz Guerke, Alexander Bachmann, Helmut Hopfer, Michael Dickenmann, Jürg Steiger, Stefan Schaub
QUESTIONS UNDER STUDY: The aim was to investigate changes in kidney allograft donor/recipient characteristics and outcomes at our centre. METHODS: We retrospectively reviewed all 2222 kidney transplantations performed between 1967 and 2015. The population was divided into four eras on the basis of time intervals corresponding to major changes in immunosuppression and pretransplant risk stratification: (i.) 1967-1980 (n = 231), (ii.) 1981-1997 (n = 883), (iii.) 1998-2004 (n = 437), (iv...
2016: Swiss Medical Weekly
Alison Teyhan, Rosie Cornish, Andy Boyd, Mary Sissons Joshi, John Macleod
BACKGROUND: Cycle accidents are a common cause of physical injury in children and adolescents. Education is one strategy to reduce cycle-related injuries. In the UK, some children undertake National Cycle Proficiency Scheme [NCPS] training (now known as Bikeability) in their final years of primary school. It aims to promote cycling and safe cycling behaviours but there has been little scientific evaluation of its effectiveness. METHODS: The sample (n = 5415) were participants in the Avon Longitudinal Study of Parents and Children who reported whether or not they had received NCPS training...
2016: BMC Public Health
Arie Drugan, Amir Weissman
Multi-fetal pregnancy reduction (MFPR) is an ethically acceptable procedure aimed to increase survival and well-being of the remaining fetuses from high-order multiple gestations. In most cases we offer the procedure to triplets or quadruplets and opt to preserve twins; lately, the option to maintain a single fetus was suggested. We examined the outcomes of 140 pregnancies that underwent MFPR in our center and were followed to delivery - 105 were reduced to twins and 35 to singletons. The rate of procedure-related pregnancy loss was identical (2...
May 24, 2016: Journal of Perinatal Medicine
Michael D Hicho, Amy Rybarczyk, Melanie Boros
PURPOSE: Results of a study to determine the number of interventions unrelated to anticoagulation made in a pharmacist-managed anticoagulation clinic are presented. METHODS: A retrospective, single-center cohort was conducted in a hospital-affiliated outpatient pharmacist-managed anticoagulation clinic. Patients were ≥18 years old and attended at least one face-to-face appointment between January 1, 2012, and November 30, 2013. The primary outcome was the number of interventions made outside of an anticoagulation clinic's primary purpose...
June 1, 2016: American Journal of Health-system Pharmacy: AJHP
Guixiang Ji, Cheng Xu, Haidong Sun, Qian Liu, Hai Hu, Aihua Gu, Zhao-Yan Jiang
BACKGROUND: Organochlorine pesticides (OCPs) are one kind of persistent organic pollutants. Although they are reported to be associated with metabolic disorders, the underlying mechanism is unclear. We explored the association of OCPs with gallstone disease and its influence on hepatic lipid metabolism. MATERIALS AND METHODS: OCPs levels in omentum adipose tissues from patients with and without gallstone disease between 2008 and 2011 were measured by GC-MS. Differences of gene expression involved in hepatic lipid metabolism and hepatic lipids content were compared in liver biopsies between groups with high and low level of OCPs...
June 7, 2016: Oncotarget
Maryam Seyedmajidi, Effat Khodadadi, Ghorban Maliji, Mohammadali Zaghian, Ali Bijani
OBJECTIVES: Saliva plays an important role in prevention of dental caries. Neutrophils are the first defense mechanism of the immune system. Interleukins (ILs) can regulate the activity of neutrophils. This study aimed to assess the neutrophil count and level of IL-lβ and IL-8 in the saliva of children with and without dental caries. MATERIALS AND METHODS: This case-control study was performed on 90 preschool children between three to five years. Children were divided into three groups of caries-free, early childhood caries (ECC) and severe early childhood caries (S-ECC)...
September 2015: Journal of Dentistry of Tehran University of Medical Sciences
Po-Han Chou, Che-Sheng Chu, Ching-Heng Lin, Chin Cheng, Yi-Huey Chen, Tsuo-Hung Lan, Min-Wei Huang
OBJECTIVE: Previous research has suggested a link between typical antipsychotic use and the development of cataracts, but the association between atypical antipsychotics and cataracts remains unclear in schizophrenia (SZ). METHODS: A retrospective nested case-control study was conducted using data from the National Health Insurance Database of Taiwan between the year of 2000 and 2011. A total of 2144 SZ patients with cataracts and 2222 controls matched for age, sex, and index date were included...
July 2016: Schizophrenia Research
Yuko Honda, Chikako Kamisato, Yoshiyuki Morishima
INTRODUCTION: Tissue factor-induced platelet aggregation and factor Xa (FXa) activity bound to clot contribute to the formation and growth of thrombus. The effects of edoxaban, a direct FXa inhibitor, on these responses were determined and compared with that of fondaparinux, an antithrombin-dependent (indirect) FXa inhibitor. MATERIAL AND METHODS: Human platelet aggregation was induced by human tissue factor (Dade Innovin or RecombiPlasTin) in platelet-rich plasma spiked with edoxaban or fondaparinux...
May 2016: Thrombosis Research
Justin Gabriel Schlager, Stefanie Rosumeck, Ricardo Niklas Werner, Anja Jacobs, Jochen Schmitt, Christoph Schlager, Alexander Nast
BACKGROUND: People with chronic plaque psoriasis often have lesions on the scalp. Hair makes the scalp difficult to treat and the adjacent facial skin is particularly sensitive to topical treatments. OBJECTIVES: To assess the efficacy and safety of topical treatments for scalp psoriasis. SEARCH METHODS: We searched the following databases up to August 2015: the Cochrane Skin Group Specialised Register, CENTRAL (2015, Issue 7), MEDLINE (from 1946), EMBASE (from 1974) and LILACS (from 1982)...
February 26, 2016: Cochrane Database of Systematic Reviews
Denis Nam, Ryan M Nunley, Staci R Johnson, James A Keeney, John C Clohisy, Robert L Barrack
BACKGROUND: This study's purpose was to present our institution's experience with the use of a risk stratification protocol for venous thromboembolism (VTE) prophylaxis in joint arthroplasty in which "routine" risk patients receive a mobile compression device in conjunction with aspirin and "high"-risk patients receive warfarin for thromboprophylaxis. METHODS: This was a prospective study of patients undergoing primary or revision knee or hip arthroplasty. Exclusion criteria were patients with a current deep vein thrombosis, history of pulmonary embolism, chronic warfarin therapy, planned multiple surgeries, and prolonged postoperative immobilization...
June 2016: Journal of Arthroplasty
Roberto Lozano, Reyes Marin, Maria-Jesus Santacruz, Asunción Pascual
OBJECTIVE: To analyze the presence of selective immunoglobulin M immunodeficiency (SIgMD) among long-term clozapine-treated outpatients in a nested case-control study. METHOD: We investigated 33 patients who took clozapine and found 6 patients with SIgMD. These patients were compared with 67 patients not taking clozapine, of whom 2 had SIgMD. Of these 6 and 2 patients, we made a group of 8 case-patients with SIgMD. This group was compared with 92 (27 + 65) patients without SIgMD matched to cases on age, sex, weight, mental health unit, diagnosis, and psychiatric medication...
2015: Primary Care Companion to CNS Disorders
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