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Carey L Holleran, Patrick W Hennessey, Abigail L Leddy, Gordhan B Mahtani, Gabrielle Brazg, Brian D Schmit, T George Hornby
BACKGROUND AND PURPOSE: Previous data suggest that large amounts of high-intensity stepping training in variable contexts (tasks and environments) may improve locomotor function, aerobic capacity, and treadmill gait kinematics in individuals poststroke. Whether similar training strategies are tolerated and efficacious for patients with other acute-onset neurological diagnoses, such as motor incomplete spinal cord injury (iSCI), is unknown. Individuals with iSCI potentially have greater bilateral impairments...
April 2018: Journal of Neurologic Physical Therapy: JNPT
Han Xia, Yujuan Wang, Chenyan Shi, Evans Atoni, Lu Zhao, Zhiming Yuan
Vast viruses are thought to be associated with mosquitoes. Anopheles sinensis, Armigeres subalbatus, Culex quinquefasciatus, and Culex tritaeniorhynchus are very common mosquito species in China, and whether the virome structure in each species is species-specific has not been evaluated. In this study, a total of 2222 mosquitoes were collected from the same geographic location, and RNAs were sequenced using the Illumina Miseq platform. After querying to the Refseq database, a total of 3,435,781, 2,223,509, 5,727,523, and 6,387,867 paired-end reads were classified under viral sequences from An...
March 2, 2018: Virologica Sinica
Alexander B Pothof, Peter A Soden, Sarah E Deery, Thomas F X O'Donnell, Grace J Wang, Kakra Hughes, Gert J de Borst, Marc L Schermerhorn
OBJECTIVE: Black patients undergoing carotid endarterectomy (CEA) in the United States are more often symptomatic at presentation and have more comorbidities compared with white patients. However, the impact of race on outcomes after CEA is largely unknown. METHODS: We identified CEA patients in the Vascular Quality Initiative registry (2012-2017) and compared them by race (black vs white). All other nonwhite races (891 [1.4%]) and Hispanics (2222 [3.4%]) were excluded...
February 23, 2018: Journal of Vascular Surgery
Gustavo Machado, Kaushi Kanankege, Val Schumann, Scott Wells, Andres Perez, Julio Alvarez
BACKGROUND: Mycobacterium avium subsp. paratuberculosis (MAP) is a widespread chronic disease of ruminants that causes severe economic losses to the dairy cattle industry worldwide. The objective of this study was to evaluate the association between individual cow MAP-ELISA and relevant milk production predictors in dairy cattle using data routinely collected as part of quality and disease control programs in the Midwest region of the U.S. Milk ELISA results of 45,652 animals from 691 herds from November 2014 to August 2016 were analyzed...
January 25, 2018: BMC Veterinary Research
Michael R Cobretti, Benjamin Bowman, Ted Grabarczyk, Emily Potter
OBJECTIVES: The dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) are effective modulators of fasting and postprandial hyperglycemia in patients with type 2 diabetes mellitus (T2DM). In 2013 the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus-Thrombolysis in Myocardial Infarction 53 (SAVOR-TIMI 53) clinical trial found an increased risk of heart failure exacerbation, as a secondary outcome, among patients treated with saxagliptin. This study examines the safety of DPP-4 inhibitors as a class in T2DM in relation to risk of heart failure exacerbations...
January 24, 2018: Pharmacotherapy
Bethany Sump, Jason H Brickner
Nuclear pore proteins (Nups) interact with chromosomes to regulate gene expression and chromatin structure. A new study by Franks and colleagues (pp. 2222-2234) provides new mechanistic insight into the molecular basis by which Nup98 promotes gene activation in normal hematopoietic cells and how that process is altered by translocations to cause excess expression of developmental genes in leukemia.
November 15, 2017: Genes & Development
Joanne Reekie, Basil Donovan, Rebecca Guy, Jane S Hocking, John M Kaldor, Donna B Mak, Sallie Pearson, David Preen, Louise Stewart, James Ward, Bette Liu
Background: There is uncertainty around whether the risks of pelvic inflammatory disease (PID) differ following Chlamydia trachomatis (chlamydia) and Neisseria gonorrhoeae (gonorrhea) infection. We quantified the risk of PID associated with chlamydia and gonorrhea infection and subsequent repeat infections in a whole-population cohort. Methods: A cohort of 315123 Western Australian women, born during 1974-1995, was probabilistically linked to chlamydia and gonorrhea testing records and to hospitalizations and emergency department presentations for PID from 2002 to 2013...
November 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Lizi Xia, Henk de Vries, Xue Yang, Eelke B Lenselink, Athina Kyrizaki, Francis Barth, Julien Louvel, Matthias K Dreyer, Daan van der Es, Adriaan P IJzerman, Laura H Heitman
While equilibrium binding affinities and in vitro functional antagonism of CB1 receptor antagonists have been studied in detail, little is known on the kinetics of their receptor interaction. In this study, we therefore conducted kinetic assays for nine 1-(4,5-diarylthiophene-2-carbonyl)-4-phenylpiperidine-4-carboxamide derivatives and included the CB1 antagonist rimonabant as a comparison. For this we newly developed a dual-point competition association assay with [3 H]CP55940 as the radioligand. This assay yielded Kinetic Rate Index (KRI) values from which structure-kinetics relationships (SKR) of hCB1 receptor antagonists could be established...
November 2, 2017: Biochemical Pharmacology
Shazna Rob, Patrick Jones, Amelia Pietropaolo, Stephen Griffin, Bhaskar K Somani
PURPOSE OF REVIEW: The incidence of urinary stone disease among the paediatric population is increasing. Whilst there has been a rise in the number of original studies published on ureteroscopy (URS) in children, critical review still remains under-reported. RECENT FINDINGS: A Cochrane style systematic review was performed to identify all original articles on URS (minimum of 25 cases) for stone disease in paediatric patients between Jan. 1996 and Dec. 2016. Based on the number of reported cases, centres were divided into medium (25-49 cases) and high (≥ 50 cases) volume studies...
October 18, 2017: Current Urology Reports
Pablo A Raffo, Sebastián Suárez, Adolfo C Fantoni, Ricardo Baggio, Fabio D Cukiernik
After reporting the structure of a new polymorph of 1,3,5-trifluoro-2,4,6-triiodobenzene (denoted BzF3I3), C6F3I3, (I), which crystallized in the space group P21/c, we perform a comparative analysis with the already reported P21/n polymorph, (II) [Reddy et al. (2006). Chem. Eur. J. 12, 2222-2234]. In polymorph (II), type-II I...I halogen bonds and I...π interactions connect molecules in such a way that a three-dimensional structure is formed; however, the way in which molecules are connected in polymorph (I), through type-II I...
September 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
Carl Michael Galang, Katherine R Naish, Keon Arbabi, Sukhvinder S Obhi
Excitability in the motor cortex is modulated when we observe other people receiving a painful stimulus (Avenanti et al., Nat Neurosci 8(7):955-960, 2005). However, the task dependency of this modulation is not well understood, as different paradigms have yielded seemingly different results. Previous neurophysiological work employing transcranial magnetic stimulation (TMS) suggests that watching another person's hand being pierced by a needle leads to a muscle specific inhibition, assessed via motor evoked potentials...
November 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Wonhwa Lee, HeeSeung Lee, Mi-Ae Kim, Joonhyeok Choi, Kyung-Min Kim, Jae Sam Hwang, MinKyun Na, Jong-Sup Bae
The edible grasshopper Oxya chinensis sinuosa is consumed worldwide for its various medicinal effects. The purpose of this study was to investigate potential bioactive antithrombotic and antiplatelet compounds from O. chinensis sinuosa. Five N-acetyldopamine dimers (1-5) were isolated from O. chinensis sinuosa and compounds 1 and 2 were identified as new chemicals with chiral centers at H-2 and H-3 of the benzo-1,4-dioxane structure. Compounds 1-4 were found to have both FXa and platelet aggregation inhibitory activities...
August 11, 2017: Scientific Reports
(no author information available yet)
[This retracts the article DOI: 10.3980/j.issn.2222-3959.2015.01.27.].
2017: International Journal of Ophthalmology
Cate M Cameron, Jodie M Osborne, Anneliese B Spinks, Tamzyn M Davey, Neil Sipe, Roderick J McClure
BACKGROUND: Longitudinal research is subject to participant attrition. Systemic differences between retained participants and those lost to attrition potentially bias prevalence of outcomes, as well as exposure-outcome associations. This study examines the impact of attrition on the prevalence of child injury outcomes and the association between sociodemographic factors and child injury. METHODS: Participants were recruited as part of the Environments for Healthy Living (EFHL) birth cohort study...
June 30, 2017: BMJ Open
Emma Pailler, Marianne Oulhen, Isabelle Borget, Jordi Remon, Kirsty Ross, Nathalie Auger, Fanny Billiot, Maud Ngo Camus, Frédéric Commo, Colin R Lindsay, David Planchard, Jean-Charles Soria, Benjamin Besse, Françoise Farace
The duration and magnitude of clinical response are unpredictable in ALK-rearranged non-small cell lung cancer (NSCLC) patients treated with crizotinib, although all patients invariably develop resistance. Here, we evaluated whether circulating tumor cells (CTC) with aberrant ALK-FISH patterns [ALK-rearrangement, ALK-copy number gain (ALK-CNG)] monitored on crizotinib could predict progression-free survival (PFS) in a cohort of ALK-rearranged patients. Thirty-nine ALK-rearranged NSCLC patients treated with crizotinib as first ALK inhibitor were recruited prospectively...
May 1, 2017: Cancer Research
Wonhwa Lee, Sae-Kwang Ku, Mi-Ae Kim, Jong-Sup Bae
Zingerone (ZGR), a phenolic alkanone found in Zingiber officinale, has been reported to have various pharmacological activities such as anti-inflammatory, anti-apoptotic, and protecting myocardial infarction and irritable bowel disorder. The aim was to identify the unreported bioactive anti-factor Xa (FXa) and anti-platelet activities of ZGR. ZGR was evaluated for their anti-FXa and anti-platelet aggregation properties by monitoring clotting time, platelet aggregation, FXa activity and production, and thrombus formation...
July 2017: Food and Chemical Toxicology
David K Whitaker, Jerry P Nolan, Maaret Castrén, Carmel Abela, Zeev Goldik
No abstract text is available yet for this article.
March 22, 2017: Resuscitation
Fei Luo, Ya-Shen Wang, Yan-Hui Su, Zhi-Hua Zhang, Hong-Hong Sun, Jian Li
The prognostic significance of preoperative anemia (PA) has been identified in various malignancies. However, its predictive role in urothelial carcinoma (UC) remains controversial. The aim of this study was to investigate the prognostic value of PA in UC patients. We performed a meta-analysis of the association between PA and survival outcome in UC patients. Electronic databases were searched up to June 30, 2016. Study characteristics and prognostic data were extracted from each included study. Cancer-specific survival (CSS), recurrence-free survival (RFS), and overall survival (OS) were pooled using hazard ratio (HR) with corresponding 95% confidence intervals (CI)...
2017: PloS One
Alanna M Chamberlain, Shannon M Dunlay, Yariv Gerber, Sheila M Manemann, Ruoxiang Jiang, Susan A Weston, Véronique L Roger
OBJECTIVE: To study the temporal distribution and causes of hospitalizations after heart failure (HF) diagnosis. PATIENTS AND METHODS: Hospitalizations were studied in 1972 Olmsted County, Minnesota, residents with incident HF from January 1, 2000, to December 31, 2011. All hospitalizations were examined for the 2 years following incident HF, and each was categorized as due to HF, other cardiovascular causes, or noncardiovascular causes. Negative binomial regression examined associations between time periods (0-30, 31-182, 183-365, and 366-730 days after diagnosis) and hospitalizations...
February 2017: Mayo Clinic Proceedings
Masayo Kojima, Takeo Nakayama, Takashi Otani, Mieko Hasegawa, Yutaka Kawahito, Yuko Kaneko, Mitsumasa Kishimoto, Shintaro Hirata, Yohei Seto, Hirahito Endo, Hiromu Ito, Toshihisa Kojima, Keiichiro Nishida, Isao Matsushita, Kiichiro Tsutani, Ataru Igarashi, Naoyuki Kamatani, Nobuyuki Miyasaka, Hisashi Yamanaka
OBJECTIVE: Patients' values and preferences are among the key factors that determine the strength of recommendations presented in clinical practice guidelines (CPG). The aim of this study was to summarize the integration process for patients' perceptions into the development of CPG for rheumatoid arthritis (RA) management in Japan. METHODS: We used a mixed-methods approach. Questionnaires that could be self-administered were mailed to 2222 RA patients randomly selected from the Japan Rheumatism Friendship Association (JRFA) membership list that was age- and prefecture-stratified...
January 25, 2017: Modern Rheumatology
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