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https://www.readbyqxmd.com/read/29136127/risk-of-pelvic-inflammatory-disease-in-relation-to-chlamydia-and-gonorrhea-testing-repeat-testing-and-positivity-a-population-based-cohort-study
#1
Joanne Reekie, Basil Donovan, Rebecca Guy, Jane S Hocking, John M Kaldor, Donna B Mak, Sallie Pearson, David Preen, Louise Stewart, James Ward, Bette Liu
Background: There is uncertainty around whether the risks of pelvic inflammatory disease (PID) differ following Chlamydia trachomatis (chlamydia) and Neisseria gonorrhoeae (gonorrhea) infection. We quantified the risk of PID associated with chlamydia and gonorrhea infection and subsequent repeat infections in a whole-population cohort. Methods: A cohort of 315123 Western Australian women, born during 1974-1995, was probabilistically linked to chlamydia and gonorrhea testing records and to hospitalizations and emergency department presentations for PID from 2002 to 2013...
November 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29102677/kinetics-of-human-cannabinoid-1-cb1-receptor-antagonists-structure-kinetics-relationships-skrs-and-implications-for-insurmountable-antagonism
#2
Lizi Xia, Henk de Vries, Xue Yang, Eelke B Lenselink, Athina Kyrizaki, Francis Barth, Julien Louvel, Matthias Dreyer, Daan van der Es, Adriaan P IJzerman, Laura H Heitman
While equilibrium binding affinities and in vitro functional antagonism of CB1 receptor antagonists have been studied in detail, little is known on the kinetics of their receptor interaction. In this study, we therefore conducted kinetic assays for nine 1-(4,5-diarylthiophene-2-carbonyl)-4-phenylpiperidine-4-carboxamide derivatives and included the CB1 antagonist rimonabant as a comparison. For this we newly developed a dual-point competition association assay with [(3)H]CP55940 as the radioligand. This assay yielded Kinetic Rate Index (KRI) values from which structure-kinetics relationships (SKRs) of hCB1 receptor antagonists could be established...
November 1, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29046982/ureteroscopy-for-stone-disease-in-paediatric-population-is-safe-and-effective-in-medium-volume-and-high-volume-centres-evidence-from-a-systematic-review
#3
REVIEW
Shazna Rob, Patrick Jones, Amelia Pietropaolo, Stephen Griffin, Bhaskar K Somani
PURPOSE OF REVIEW: The incidence of urinary stone disease among the paediatric population is increasing. Whilst there has been a rise in the number of original studies published on ureteroscopy (URS) in children, critical review still remains under-reported. RECENT FINDINGS: A Cochrane style systematic review was performed to identify all original articles on URS (minimum of 25 cases) for stone disease in paediatric patients between Jan. 1996 and Dec. 2016. Based on the number of reported cases, centres were divided into medium (25-49 cases) and high (≥ 50 cases) volume studies...
October 18, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28872062/polymorphism-of-a-widely-used-building-block-for-halogen-bonded-assemblies-1-3-5-trifluoro-2-4-6-triiodobenzene
#4
Pablo A Raffo, Sebastián Suárez, Adolfo C Fantoni, Ricardo Baggio, Fabio D Cukiernik
After reporting the structure of a new polymorph of 1,3,5-trifluoro-2,4,6-triiodobenzene (denoted BzF3I3), C6F3I3, (I), which crystallized in the space group P21/c, we perform a comparative analysis with the already reported P21/n polymorph, (II) [Reddy et al. (2006). Chem. Eur. J. 12, 2222-2234]. In polymorph (II), type-II I...I halogen bonds and I...π interactions connect molecules in such a way that a three-dimensional structure is formed; however, the way in which molecules are connected in polymorph (I), through type-II I...
September 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28840271/observing-painful-events-in-others-leads-to-a-temporally-extended-general-response-facilitation-in-the-self
#5
Carl Michael Galang, Katherine R Naish, Keon Arbabi, Sukhvinder S Obhi
Excitability in the motor cortex is modulated when we observe other people receiving a painful stimulus (Avenanti et al., Nat Neurosci 8(7):955-960, 2005). However, the task dependency of this modulation is not well understood, as different paradigms have yielded seemingly different results. Previous neurophysiological work employing transcranial magnetic stimulation (TMS) suggests that watching another person's hand being pierced by a needle leads to a muscle specific inhibition, assessed via motor evoked potentials...
November 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28801633/evaluation-of-novel-factor-xa-inhibitors-from-oxya-chinensis-sinuosa-with-anti-platelet-aggregation-activity
#6
Wonhwa Lee, HeeSeung Lee, Mi-Ae Kim, Joonhyeok Choi, Kyung-Min Kim, Jae Sam Hwang, MinKyun Na, Jong-Sup Bae
The edible grasshopper Oxya chinensis sinuosa is consumed worldwide for its various medicinal effects. The purpose of this study was to investigate potential bioactive antithrombotic and antiplatelet compounds from O. chinensis sinuosa. Five N-acetyldopamine dimers (1-5) were isolated from O. chinensis sinuosa and compounds 1 and 2 were identified as new chemicals with chiral centers at H-2 and H-3 of the benzo-1,4-dioxane structure. Compounds 1-4 were found to have both FXa and platelet aggregation inhibitory activities...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28730120/retraction-notice
#7
(no author information available yet)
[This retracts the article DOI: 10.3980/j.issn.2222-3959.2015.01.27.].
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28667218/impact-of-participant-attrition-on-child-injury-outcome-estimates-a-longitudinal-birth-cohort-study-in-australia
#8
Cate M Cameron, Jodie M Osborne, Anneliese B Spinks, Tamzyn M Davey, Neil Sipe, Roderick J McClure
BACKGROUND: Longitudinal research is subject to participant attrition. Systemic differences between retained participants and those lost to attrition potentially bias prevalence of outcomes, as well as exposure-outcome associations. This study examines the impact of attrition on the prevalence of child injury outcomes and the association between sociodemographic factors and child injury. METHODS: Participants were recruited as part of the Environments for Healthy Living (EFHL) birth cohort study...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28461563/circulating-tumor-cells-with-aberrant-alk-copy-number-predict-progression-free-survival-during-crizotinib-treatment-in-alk-rearranged-non-small-cell-lung-cancer-patients
#9
Emma Pailler, Marianne Oulhen, Isabelle Borget, Jordi Remon, Kirsty Ross, Nathalie Auger, Fanny Billiot, Maud Ngo Camus, Frédéric Commo, Colin R Lindsay, David Planchard, Jean-Charles Soria, Benjamin Besse, Françoise Farace
The duration and magnitude of clinical response are unpredictable in ALK-rearranged non-small cell lung cancer (NSCLC) patients treated with crizotinib, although all patients invariably develop resistance. Here, we evaluated whether circulating tumor cells (CTC) with aberrant ALK-FISH patterns [ALK-rearrangement, ALK-copy number gain (ALK-CNG)] monitored on crizotinib could predict progression-free survival (PFS) in a cohort of ALK-rearranged patients. Thirty-nine ALK-rearranged NSCLC patients treated with crizotinib as first ALK inhibitor were recruited prospectively...
May 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28414123/anti-factor-xa-activities-of-zingerone-with-anti-platelet-aggregation-activity
#10
Wonhwa Lee, Sae-Kwang Ku, Mi-Ae Kim, Jong-Sup Bae
Zingerone (ZGR), a phenolic alkanone found in Zingiber officinale, has been reported to have various pharmacological activities such as anti-inflammatory, anti-apoptotic, and protecting myocardial infarction and irritable bowel disorder. The aim was to identify the unreported bioactive anti-factor Xa (FXa) and anti-platelet activities of ZGR. ZGR was evaluated for their anti-FXa and anti-platelet aggregation properties by monitoring clotting time, platelet aggregation, FXa activity and production, and thrombus formation...
July 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28341349/implementing-a-standard-internal-telephone-number-2222-for-cardiac-arrest-calls-in-all-hospitals-in-europe
#11
EDITORIAL
David K Whitaker, Jerry P Nolan, Maaret Castrén, Carmel Abela, Zeev Goldik
No abstract text is available yet for this article.
March 22, 2017: Resuscitation
https://www.readbyqxmd.com/read/28182725/prognostic-implications-of-preoperative-anemia-in-urothelial-carcinoma-a-meta-analysis
#12
Fei Luo, Ya-Shen Wang, Yan-Hui Su, Zhi-Hua Zhang, Hong-Hong Sun, Jian Li
The prognostic significance of preoperative anemia (PA) has been identified in various malignancies. However, its predictive role in urothelial carcinoma (UC) remains controversial. The aim of this study was to investigate the prognostic value of PA in UC patients. We performed a meta-analysis of the association between PA and survival outcome in UC patients. Electronic databases were searched up to June 30, 2016. Study characteristics and prognostic data were extracted from each included study. Cancer-specific survival (CSS), recurrence-free survival (RFS), and overall survival (OS) were pooled using hazard ratio (HR) with corresponding 95% confidence intervals (CI)...
2017: PloS One
https://www.readbyqxmd.com/read/28160871/burden-and-timing-of-hospitalizations-in-heart-failure-a-community-study
#13
Alanna M Chamberlain, Shannon M Dunlay, Yariv Gerber, Sheila M Manemann, Ruoxiang Jiang, Susan A Weston, Véronique L Roger
OBJECTIVE: To study the temporal distribution and causes of hospitalizations after heart failure (HF) diagnosis. PATIENTS AND METHODS: Hospitalizations were studied in 1972 Olmsted County, Minnesota, residents with incident HF from January 1, 2000, to December 31, 2011. All hospitalizations were examined for the 2 years following incident HF, and each was categorized as due to HF, other cardiovascular causes, or noncardiovascular causes. Negative binomial regression examined associations between time periods (0-30, 31-182, 183-365, and 366-730 days after diagnosis) and hospitalizations...
February 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28121192/integrating-patients-perceptions-into-clinical-practice-guidelines-for-the-management-of-rheumatoid-arthritis-in-japan
#14
Masayo Kojima, Takeo Nakayama, Takashi Otani, Mieko Hasegawa, Yutaka Kawahito, Yuko Kaneko, Mitsumasa Kishimoto, Shintaro Hirata, Yohei Seto, Hirahito Endo, Hiromu Ito, Toshihisa Kojima, Keiichiro Nishida, Isao Matsushita, Kiichiro Tsutani, Ataru Igarashi, Naoyuki Kamatani, Nobuyuki Miyasaka, Hisashi Yamanaka
OBJECTIVE: Patients' values and preferences are among the key factors that determine the strength of recommendations presented in clinical practice guidelines (CPG). The aim of this study was to summarize the integration process for patients' perceptions into the development of CPG for rheumatoid arthritis (RA) management in Japan. METHODS: We used a mixed-methods approach. Questionnaires that could be self-administered were mailed to 2222 RA patients randomly selected from the Japan Rheumatism Friendship Association (JRFA) membership list that was age- and prefecture-stratified...
January 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/27942352/complete-genome-anatomy-of-the-emerging-potato-pathogen-dickeya-solani-type-strain-ipo-2222-t
#15
Slimane Khayi, Pauline Blin, Teik Min Chong, Kok-Gan Chan, Denis Faure
Several species of the genus Dickeya provoke soft rot and blackleg diseases on a wide range of plants and crops. Dickeya solani has been identified as the causative agent of diseases outbreaks on potato culture in Europe for the last decade. Here, we report the complete genome of the D. solani IPO 2222(T). Using PacBio and Illumina technologies, a unique circular chromosome of 4,919,833 bp was assembled. The G + C content reaches 56% and the genomic sequence contains 4,059 predicted proteins. The ANI values calculated for D...
2016: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/27926753/in-vivo-observation-of-lens-regeneration-in-rat-using-ultra-long-scan-depth-optical-coherence-tomography
#16
Kai-Jing Zhou, Yi-Ni Li, Fu-Rong Huang, Qin-Mei Wang, A-Yong Yu
Purpose: To evaluate morphologic changes of lens regeneration in rats in vivo after extracapsular lens extraction (ECLE) by ultra-long scan depth optical coherence tomography (UL-OCT). Methods: A total of 42 Sprague-Dawley rats were used in this study. We performed ECLE on the right eyes of animals in the surgery group (n = 34). Biomicroscopy and UL-OCT scans were carried out for the surgery group immediately (within 1 hour postoperatively) and at days 1 and 3, weeks 1 and 2, and months 1, 2, and 3 postoperatively...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27863647/a-tonsillectomy-increased-the-risk-of-chronic-rhinosinusitis-among-children-a-three-year-follow-up-study
#17
Shiu-Dong Chung, Herng-Ching Lin, Chuan-Song Wu, Li-Ting Kao, Shih-Han Hung
OBJECTIVES: The study aimed to estimate the risk of developing chronic rhinosinusitis (CRS) among children who had undergone a tonsillectomy by utilizing a cohort study based on a population-based database. METHODS: Data for this retrospective cohort study were sourced from the Taiwan "Longitudinal Health Insurance Database 2000". We included 202 children who had undergone a tonsillectomy as the study group and 2020 sex- and age-matched children as the comparison group...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27765484/sequencing-and-comparative-analyses-of-aegilops-tauschii-chromosome-arm-3ds-reveal-rapid-evolution-of-triticeae-genomes
#18
COMPARATIVE STUDY
Jingzhong Xie, Naxin Huo, Shenghui Zhou, Yi Wang, Guanghao Guo, Karin R Deal, Shuhong Ouyang, Yong Liang, Zhenzhong Wang, Lichan Xiao, Tingting Zhu, Tiezhu Hu, Vijay Tiwari, Jianwei Zhang, Hongxia Li, Zhongfu Ni, Yingyin Yao, Huiru Peng, Shengli Zhang, Olin D Anderson, Patrick E McGuire, Jan Dvorak, Ming-Cheng Luo, Zhiyong Liu, Yong Q Gu, Qixin Sun
Bread wheat (Triticum aestivum, AABBDD) is an allohexaploid species derived from two rounds of interspecific hybridizations. A high-quality genome sequence assembly of diploid Aegilops tauschii, the donor of the wheat D genome, will provide a useful platform to study polyploid wheat evolution. A combined approach of BAC pooling and next-generation sequencing technology was employed to sequence the minimum tiling path (MTP) of 3176 BAC clones from the short arm of Ae. tauschii chromosome 3 (At3DS). The final assembly of 135 super-scaffolds with an N50 of 4...
January 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27754881/assessment-of-the-european-society-of-cardiology-0-hour-1-hour-algorithm-to-rule-out-and-rule-in-acute-myocardial-infarction
#19
MULTICENTER STUDY
John W Pickering, Jaimi H Greenslade, Louise Cullen, Dylan Flaws, William Parsonage, Sally Aldous, Peter George, Andrew Worster, Peter A Kavsak, Martin P Than
BACKGROUND: The new European Society of Cardiology guidelines to rule-in and rule-out acute myocardial infarction (AMI) in the emergency department include a rapid assessment algorithm based on high-sensitivity cardiac troponin and sampling at 0 and 1 hour. Emergency department physicians require high sensitivity to confidently rule-out AMI, whereas cardiologists aim to minimize false-positive results. METHODS: High-sensitivity troponin I and T assays were used to measure troponin concentrations in patients presenting with chest-pain symptoms and being investigated for possible acute coronary syndrome at hospitals in New Zealand, Australia, and Canada...
November 15, 2016: Circulation
https://www.readbyqxmd.com/read/27744486/changes-in-chemotherapy-usage-and-outcome-of-early-breast-cancer-patients-in-the-last-decade
#20
A Hennigs, F Riedel, F Marmé, P Sinn, K Lindel, A Gondos, K Smetanay, M Golatta, C Sohn, F Schuetz, J Heil, A Schneeweiss
BACKGROUND: During the last decade, neoadjuvant chemotherapy (NACT) of early breast cancer (EBC) evolved from a therapy intended to enable operability to a standard treatment option aiming for increasing cure rates equivalent to adjuvant chemotherapy (ACT). In parallel, improvements in the quality control of breast cancer care have been established in specialized breast care units. PATIENTS AND METHODS: This study analyzed chemotherapy usage in patients with EBC treated at the Heidelberg University Breast Unit between January 2003 and December 2014...
December 2016: Breast Cancer Research and Treatment
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