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Tamas Szakmany, Robert M Lundin, Ben Sharif, Gemma Ellis, Paul Morgan, Maja Kopczynska, Amrit Dhadda, Charlotte Mann, Danielle Donoghue, Sarah Rollason, Emma Brownlow, Francesca Hill, Grace Carr, Hannah Turley, James Hassall, James Lloyd, Llywela Davies, Michael Atkinson, Molly Jones, Nerys Jones, Rhodri Martin, Yousef Ibrahim, Judith E Hall
Data on sepsis prevalence on the general wards is lacking on the UK and in the developed world. We conducted a multicentre, prospective, observational study of the prevalence of patients with sepsis or severe sepsis on the general wards and Emergency Departments (ED) in Wales. During the 24-hour study period all patients with NEWS≥3 were screened for presence of 2 or more SIRS criteria. To be eligible for inclusion, patients had to have a high clinical suspicion of an infection, together with a systemic inflammatory response (sepsis) and evidence of acute organ dysfunction and/or shock (severe sepsis)...
2016: PloS One
Marsha Elkhunovich, Joanna Barreras, Valerie Bock Pinero, Nurit Ziv, Aisha Vaiyani, Thomas Mailhot
PURPOSE: Children receiving treatment in the hospital frequently require intravenous (IV) access. Placement of short peripheral catheters can be painful and challenging especially in those children who have difficult access. Many children's hospitals have teams of specialized vascular access nurses experienced in peripheral catheter insertion, and at times use vein visualization devices, including ultrasound (US), to assist in peripheral IV placement. Our objectives were to describe the prevalence and success rate of US-guided peripheral IV placement by vascular access team nurses at a single tertiary children's hospital...
November 15, 2016: Journal of Vascular Access
Bijuan Chen, Zheng Deng, Wenmin Li, Moran Gao, Qingqing Liu, C Z Gu, F X Hu, B G Shen, Benjamin Frandsen, Sky Cheung, Liu Lian, Yasutomo J Uemura, Cui Ding, Shengli Guo, Fanlong Ning, Timothy J S Munsie, Murray Neff Wilson, Yipeng Cai, Graeme Luke, Zurab Guguchia, Shingo Yonezawa, Zhi Li, Changqing Jin
We report the discovery of a new fluoride-arsenide bulk diluted magnetic semiconductor (Ba,K)F(Zn,Mn)As with the tetragonal ZrCuSiAs-type structure which is identical to that of the "1111" iron-based superconductors. The joint hole doping via (Ba,K) substitution &spin doping via (Zn,Mn) substitution results in ferromagnetic order with Curie temperature up to 30 K and demonstrates that the ferromagnetic interactions between the localized spins are mediated by the carriers. Muon spin relaxation measurements confirm the intrinsic nature of the long range magnetic order in the entire volume in the ferromagnetic phase...
November 22, 2016: Scientific Reports
Jedrzej Kosiuk, Sebastian Hilbert, Silke John, Livio Bertagnolli, Gerhard Hindricks, Andreas Bollmann
BACKGROUND: Recently, a novel electroanatomic mapping system enabling rapid and automatic acquisition of high-resolution maps has been introduced. Previous reports focused on system use in combination with a mini-basket catheter. However, a novel system-specific, magnet-enabled ablation catheter eliminates the need for the mini-basket catheter and can potentially reduce procedure complexity and cost. Here we present our first experience from two consecutive case series using both procedural settings...
November 13, 2016: International Journal of Cardiology
(no author information available yet)
The above article, published online on November 6, 2015 in Wiley Online Library (, has been retracted by agreement between the authors, the journal Editor in Chief, Thomas M. Ruenger, MD PhD and John Wiley & Sons Ltd. The retraction has been agreed as the clinical trial reported in this manuscript was not approved by the local Ethics Committee. Reference Calzavara-Pinton PG, Rossi MT, Zanca A, Arisi M, Gonzalez S, Venturini M. Oral Polypodium leucomotos increases the anti-inflammatory and melanogenic responses of the skin to different modalities of sun exposures: a pilot study...
September 2016: Photodermatology, Photoimmunology & Photomedicine
María Jesús Valero-Masa, Jesús Velásquez-Rodríguez, Felipe Diez-Delhoyo, Carolina Devesa, Miriam Juárez, Iago Sousa-Casasnovas, Rocío Angulo-Llanos, Francisco Fernández-Avilés, Manuel Martínez-Sellés
BACKGROUND: Several studies have shown that, after an acute myocardial infarction, women have worse prognosis than males. However, it is not clear if female sex is an independent predictor of mortality risk. Our aim was to analyse sex influence on the prognosis of these patients. METHODS: Retrospective registry of patients with ST segment elevation myocardial infarction (STEMI) from January 2010 to April 2015. RESULTS: From 1111 patients, 258 (23...
November 9, 2016: International Journal of Cardiology
Tom A J de Jager, Karolijn Dulfer, Kimberley Pieters, Elisabeth M W J Utens, Joost Daemen, Mattie J Lenzen, Ron T van Domburg
BACKGROUND: Poor subjective health status significantly predicted short-term mortality in patients with coronary artery disease (CAD). However, the relation between subjective health status and long-term mortality remains limited in patients treated with PCI. The aim of this study is to investigate the association between subjective health status and 14-year mortality in patients treated with percutaneous coronary intervention (PCI). METHODS: A consecutive cohort with 1111 patients treated for CAD who completed the SF-36 questionnaire was included between 2001 and 2002 as part of the RESEARCH registry...
November 9, 2016: International Journal of Cardiology
Nelly Tan, Wei-Chan Lin, Pooria Khoshnoodi, Nazanin H Asvadi, Jeffrey Yoshida, Daniel J A Margolis, David S K Lu, Holden Wu, Kyung Hyun Sung, David Y Lu, Jaioti Huang, Steven S Raman
Purpose To determine the diagnostic yield of in-bore 3-T magnetic resonance (MR) imaging-guided prostate biopsy and stratify performance according to Prostate Imaging Reporting and Data System (PI-RADS) versions 1 and 2. Materials and Methods This study was HIPAA compliant and institution review board approved. In-bore 3-T MR-guided prostate biopsy was performed in 134 targets in 106 men who (a) had not previously undergone prostate biopsy, (b) had prior negative biopsy findings with increased prostate-specific antigen (PSA) level, or (c) had a prior history of prostate cancer with increasing PSA level...
November 18, 2016: Radiology
Wolfgang Goymann, Ignas Safari, Christina Muck, Ingrid Schwabl
The decision to provide parental care is often associated with trade-offs, because resources allocated to parental care typically cannot be invested in self-maintenance or mating. In most animals, females provide more parental care than males, but the reason for this pattern is still debated in evolutionary ecology. To better understand sex differences in parental care and its consequences, we need to study closely related species where the sexes differ in offspring care. We investigated parental care in relation to offspring growth in two closely related coucal species that fundamentally differ in sex roles and parental care, but live in the same food-rich habitat with a benign climate and have a similar breeding phenology...
October 2016: Royal Society Open Science
Jonathan Mailman, Jeffrey Betcher, William Semchuk
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
J A Reeger, B Fornberg, M L Watts
The numerical approximation of definite integrals, or quadrature, often involves the construction of an interpolant of the integrand and its subsequent integration. In the case of one dimension it is natural to rely on polynomial interpolants. However, their extension to two or more dimensions can be costly and unstable. An efficient method for computing surface integrals on the sphere is detailed in the literature (Reeger & Fornberg 2016 Stud. Appl. Math.137, 174-188. (doi:10.1111/sapm.12106)). The method uses local radial basis function interpolation to reduce computational complexity when generating quadrature weights for any given node set...
October 2016: Proceedings. Mathematical, Physical, and Engineering Sciences
Rachel van der Pols-Vijlbrief, Hanneke A H Wijnhoven, Judith E Bosmans, Jos W R Twisk, Marjolein Visser
BACKGROUND & AIMS: Undernutrition in old age is associated with increased morbidity, mortality and health care costs. Treatment by caloric supplementation results in weight gain, but compliance is poor in the long run. Few studies targeted underlying causes of undernutrition in community-dwelling older adults. This study aimed to evaluate the cost-effectiveness of a multifactorial personalized intervention focused on eliminating or managing the underlying causes of undernutrition to prevent and reduce undernutrition in comparison with usual care...
October 15, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Yuji Suzuki, Eri Kondo, Amane Makino
Metabolome analyses have indicated an accumulation of sedoheptulose 7-phosphate in transgenic rice plants with overproduction of Rubisco (Suzuki et al. in Plant Cell Environ 35:1369-1379, 2012. doi: 10.1111/j.1365-3040.2012.02494.x ). Since Rubisco overproduction did not quantitatively enhance photosynthesis even under CO2-limited conditions, it is suspected that such an accumulation of sedoheptulose 7-phosphate hampers the improvement of photosynthetic capacity. In the present study, the gene of transketolase, which is involved in the metabolism of sedoheptulose 7-phosphate, was co-overexpressed with the Rubisco small subunit gene in rice...
November 5, 2016: Photosynthesis Research
Natalia Romero-Franco, Pedro Jiménez-Reyes, Adrián Castaño-Zambudio, Fernando Capelo-Ramírez, Juan José Rodríguez-Juan, Jorge González-Hernández, Francisco Javier Toscano-Bendala, Víctor Cuadrado-Peñafiel, Carlos Balsalobre-Fernández
The purpose of this study was to assess validity and reliability of sprint performance outcomes measured with an iPhone application (named: MySprint) and existing field methods (i.e. timing photocells and radar gun). To do this, 12 highly trained male sprinters performed 6 maximal 40-m sprints during a single session which were simultaneously timed using 7 pairs of timing photocells, a radar gun and a newly developed iPhone app based on high-speed video recording. Several split times as well as mechanical outputs computed from the model proposed by Samozino et al...
November 3, 2016: European Journal of Sport Science
Veronika Vymetalkova, Barbara Pardini, Fabio Rosa, Katerina Jiraskova, Cornelia Di Gaetano, Petra Bendova, Miloslav Levy, Veronika Veskrnova, Tomas Buchler, Ludmila Vodickova, Alessio Naccarati, Pavel Vodicka
Polymorphisms in microRNA (miRNA) binding sites may affect miRNA/target gene interaction, resulting in differential mRNA/protein expression and susceptibility to common diseases. Mucins have been identified as markers of adverse prognosis. We hypothesized that genetic variations in miRNA binding sites located in mucin genes may modulate signaling response and the maintenance of genomic stability ultimately affecting cancer susceptibility, efficacy of chemotherapy and survival.In the present study, we analyzed the association of single nucleotide polymorphisms in predicted miRNA target sites (miRSNPs) of mucin genes with colorectal cancer (CRC) risk and clinical outcome...
November 1, 2016: Carcinogenesis
D G Evans, E R Woodward, S J Howell, S Verhoef, A Howell, F Lalloo
To assess the need for adjustment in the likelihood of germline BRCA1/2 mutations in women with HER2+ breast cancers. We analysed primary mutation screens on women with breast cancer with unequivocal HER2 overexpression and assessed the likelihood of BRCA1/BRCA2 mutations by age, oestrogen receptor status and Manchester score. Of 1111 primary BRCA screens with confirmed HER2 status only 4/161 (2.5%) of women with HER2 amplification had a BRCA1 mutation identified and 5/161 (3.1%) a BRCA2 mutation. The pathology adjusted Manchester score between 10 and 19% and 20%+ thresholds resulted in a detection rate of only 6...
October 31, 2016: Familial Cancer
Wenchao Sun, Min Zheng, Huihui Cao, Huijun Lu, Xiankai Wei, Yi Pan, Hongyun Zhang, Jiaoxiu Su, Jun Li, Ningyi Jin
In this study, YN26/2013, a novel recombinant duck circovirus (DuCV), was isolated from a Muscovy duck in Yunnan Province, southern China. The whole genome of YN26/2013 consists of 1,987 nucleotides (nt), the same genomic size as that of the DuCV-2 genotype. However, YN26/2013 shares 91.5 to 94.3% nucleotide identity similarity with previously reported type I (DuCV-1) viruses. Importantly, a novel putative recombinant event between DuCV-1 and DuCV-2 was identified as occurring within the 987- to 1111-nt region of the YN26/2013 genome...
October 20, 2016: Genome Announcements
Jean-Martin Beaulieu
Read the highlighted article 'Chronic lithium treatment rectifies maladaptive dopamine release in the nucleus accumbens' on page 576.
November 2016: Journal of Neurochemistry
Sanna Nybacka, Heléne Bertéus Forslund, Elisabet Wirfält, Ingrid Larsson, Ulrika Ericson, Eva Warensjö Lemming, Göran Bergström, Bo Hedblad, Anna Winkvist, Anna Karin Lindroos
Two web-based dietary assessment tools have been developed for use in large-scale studies: the Riksmaten method (4-d food record) and MiniMeal-Q (food-frequency method). The aim of the present study was to examine the ability of these methods to capture energy intake against objectively measured total energy expenditure (TEE) with the doubly labelled water technique (TEEDLW), and to compare reported energy and macronutrient intake. This study was conducted within the pilot study of the Swedish CArdioPulmonary bioImage Study (SCAPIS), which included 1111 randomly selected men and women aged 50-64 years from the Gothenburg general population...
2016: Journal of Nutritional Science
W Frank Peacock
No abstract text is available yet for this article.
December 2, 2016: Journal of Neurotrauma
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