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https://www.readbyqxmd.com/read/29451706/insulin-degludec-insulin-aspart-lowers-fasting-plasma-glucose-and-rates-of-confirmed-and-nocturnal-hypoglycaemia-independent-of-baseline-hba-1c-levels-disease-duration-or-bmi-a-pooled-meta-analysis-of-phase-3-studies-in-patients-with-type-2-diabetes
#1
Martin Haluzík, Greg Fulcher, Thomas R Pieber, Lars Bardtrum, Deniz Tutkunkardas, Helena W Rodbard
AIMS: Previous studies demonstrated the co-formulation of insulin degludec (IDeg)/insulin aspart (IAsp) 'IDegAsp' offers lower rates of hypoglycaemia with smaller changes in weight compared with basal-bolus (IDeg once daily [OD] + IAsp [2-4 injections]) and premix insulin (BIAsp 30 twice daily [BID]) comparators. This study aimed to investigate whether the benefits of IDegAsp, given twice daily, extend across a wide spectrum of patients with diabetes. MATERIALS AND METHODS: This was a post hoc pooled analysis of five phase 3 randomised, 26-week, open-label, BID, treat-to-target trials comparing IDegAsp BID (n = 1111) with one of two 'comparators' - BIAsp 30 BID (n = 561) or IDeg OD + IAsp (n = 136)...
February 16, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29449294/disease-characteristics-and-management-of-hospitalised-adolescents-and-adults-with-community-acquired-pneumonia-in-china-a-retrospective-multicentre-survey
#2
Liang Chen, Fei Zhou, Hui Li, Xiqian Xing, Xiudi Han, Yiming Wang, Chunxiao Zhang, Lijun Suo, Jingxiang Wang, Guohua Yu, Guangqiang Wang, Xuexin Yao, Hongxia Yu, Lei Wang, Meng Liu, Chunxue Xue, Bo Liu, Xiaoli Zhu, Yanli Li, Ying Xiao, Xiaojing Cui, Lijuan Li, Timothy M Uyeki, Chen Wang, Bin Cao
OBJECTIVES: To describe the clinical characteristics and management of patients hospitalised with community-acquired pneumonia (CAP) in China. DESIGN: This was a multicentre, retrospective, observational study. SETTING: 13 teaching hospitals in northern, central and southern China from 1 January 2014 to 31 December 2014 PARTICIPANTS: Information on hospitalised patients aged ≥14 years with radiographically confirmed pneumonia with illness onset in the community was collected using standard case report forms...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29442371/good-daphnia-parents-do-not-control-the-offspring-microbiome
#3
Angela E Douglas
In Focus: Mushegian, A. A., Walser, J. -C., Sullam, K. E., & Ebert, D. (2018). The microbiota of diapause: How host-microbe associations are formed after dormancy in an aquatic crustacean. Journal of Animal Ecology, 87, 400-413. https://doi.org/10.1111/1365-2656.12709. All animals are colonized by micro-organisms, most of which are benign or beneficial. Where do these micro-organisms come from? Theory predicts that micro-organisms which are transmitted vertically from parent to offspring are especially likely to be beneficial to the host, while horizontally acquired micro-organisms are opportunistic and more variable in their impact on host performance...
March 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29437848/new-decision-formulas-for-predicting-endotracheal-tube-depth-in-children-analysis-of-neck-ct-images
#4
Se Uk Lee, Jae Yun Jung, Do Kyun Kim, Young Ho Kwak, Hyuksool Kwon, Jun Hwi Cho, Joong Wan Park, Yoo Jin Choi
INTRODUCTION: The purpose of this study was to construct a prediction model for endotracheal tube depth using neck CT images. METHODS: A retrospective image review was conducted that included patients who had undergone neck CT. Using sagittal neck CT images, we calculated the length between upper incisor and mid-trachea and then derived the model via regression analysis. The model was validated externally using chest radiographs of patients who had undergone endotracheal intubation...
February 6, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29433158/corrigendum-for-spaak-et%C3%A2-al-2017-doi-10-1111-ele-12828
#5
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Ecology Letters
https://www.readbyqxmd.com/read/29427301/prospective-validation-and-refinement-of-a-decision-rule-to-obtain-cxr-in-patients-with-non-traumatic-chest-pain-in-the-ed
#6
Case Newsom, Rebecca Jeanmonod, Wendy Woolley, Nirali Shah, Shellie Asher, Eric Bruno, Michael Silberman, Mark Reiter, Donald Jeanmonod
OBJECTIVES: To prospectively validate and refine previously published criteria to determine the potential utility of chest x-ray (CXR) in the evaluation and management of patients presenting to the emergency department (ED) with non-traumatic chest pain. METHODS: A prospective observational study was performed of patients presenting to three EDs in the US with a chief complaint of non-traumatic chest pain. Previously defined high-risk history and exam elements were combined into a refined decision rule and these elements were recorded for each patient by the ED physician...
February 10, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29412218/thinning-regimes-and-initial-spacing-for-eucalyptus-plantations-in-brazil
#7
Antonio C Ferraz Filho, Blas Mola-Yudego, José R González-Olabarria, José Roberto S Scolforo
This study focuses on the effects of different thinning regimes on clonal Eucalyptus plantations growth. Four different trials, planted in 1999 and located in Bahia and Espírito Santo States, were used. Aside from thinning, initial planting density, and post thinning fertilization application were also evaluated. Before canopy closure, and therefore before excessive competition between trees took place, it was found that stands planted under low densities (667 trees per hectare) presented a lower mortality proportion when compared to stand planted under higher densities (1111 trees per hectare)...
February 5, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29399985/retraction
#8
(no author information available yet)
'EphB3-targeted regulation of miR-149 in the migration and invasion of human colonic carcinoma HCT116 and SW620 cells' by Guodong Zhang, Xiaozhu Liu, Yinfeng Li, Yan Wang, Huankun Liang, Kangyan Li, Laiqing Li, Cuicui Chen, Wenqiao Sun, Shoulei Ren, Pengfei Zhu and Licheng Zhang1 . The above article from Cancer Science, first published on 3 April 2017 in Wiley Online Library (wileyonlinelibrary.com) and in Volume 108, pp. 408-418, has been retracted by the journal Editor in Chief, Yusuke Nakamura, and John Wiley & Sons Australia, Ltd...
February 2018: Cancer Science
https://www.readbyqxmd.com/read/29397331/fecal-calprotectin-and-serum-albumin-as-markers-of-gastrointestinal-graft-versus-host-disease
#9
Larisa Broglie, Alfred Rademaker, John Galvin, Ayita Ray, William T Tse, Reggie Duerst, Jennifer Schneiderman, Morris Kletzel, Sonali Chaudhury
BACKGROUND: Acute graft versus host disease (aGVHD) affects approximately 30-60% of patients after allogeneic hematopoietic stem cell transplantation (HCT) and our ability to predict who develops this complication and their response to treatment is limited. Fecal calprotectin has recently gained popularity as an effective marker of GI inflammation in patients with Inflammatory Bowel Disease (IBD). METHODS: Fecal calprotectin and albumin were evaluated as prognostic and predictive markers of aGVHD in 60 adult and pediatric HCT patients...
January 31, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29383978/of-two-minds-or-one-a-registered-replication-of-rydell-et%C3%A2-al-2006
#10
Tobias Heycke, Sarah Gehrmann, Julia M Haaf, Christoph Stahl
Evaluative conditioning (EC) is proposed as a mechanism of automatic preference acquisition in dual-process theories of attitudes (Gawronski, B., & Bodenhausen, G. V. (2006). Associative and propositional processes in evaluation: An integrative review of implicit and explicit attitude change. Psychological Bulletin, 132(5), 692-731. doi:10.1037/0033-2909.132.5.692). Evidence for the automaticity of EC comes from studies claiming EC effects for subliminally presented stimuli. An impression-formation study showed a selective influence of briefly presented primes on implicitly measured attitudes, whereas supraliminally presented behavioural information about the target person was reflected in explicit ratings (Rydell, R...
January 31, 2018: Cognition & Emotion
https://www.readbyqxmd.com/read/29382255/warm-and-touching-tears-tearful-individuals-are-perceived-as-warmer-because-we-assume-they-feel-moved-and-touched
#11
Janis H Zickfeld, Thomas W Schubert
Recent work investigated the inter-individual functions of emotional tears in depth. In one study (Van de Ven, N., Meijs, M. H. J., & Vingerhoets, A. (2017). What emotional tears convey: Tearful individuals are seen as warmer, but also as less competent. British Journal of Social Psychology, 56(1), 146-160. Https://doi.org/10.1111/bjso.12162) tearful individuals were rated as warmer, and participants expressed more intentions to approach and help such individuals. Simultaneously, tearful individuals were rated as less competent, and participants expressed less intention to work with the depicted targets...
January 31, 2018: Cognition & Emotion
https://www.readbyqxmd.com/read/29372570/wnt-is-here-could-wnt-signalling-be-promoted-to-protect-against-alzheimer-disease-an-editorial-for-wnt-signaling-loss-accelerates-the-appearance-of-neuropathological-hallmarks-of-alzheimer-s-disease-in-j20-%C3%A2-app-transgenic-and-wild-type-mice-on-doi-10-1111
#12
EDITORIAL
Brett Garner, Lezanne Ooi
This Editorial highlights an article in the current issue by Tapia-Rojas and Inestrosa suggesting that attenuation of Wnt signalling may be a triggering factor for the pathogenesis of Alzheimer disease (AD) in the J20 mouse model of AD. Their study utilises Wnt signalling inhibitors that operate at different points in the signalling pathway. The molecular changes of several key Wnt signaling components are examined, along with a thorough analysis of both the amyloid and tau based pathologies in the mouse brain...
January 26, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29363050/effect-of-age-related-factors-on-the-pharmacokinetics-of-lamotrigine-and-potential-implications-for-dose-optimisation-in-epilepsy-patients
#13
Sven C van Dijkman, Nico C B de Jager, Willem M Rauwé, Meindert Danhof, Oscar Della Pasqua
BACKGROUND AND AIMS: In this study, we evaluate the performance of allometric concepts to predict the implications of age and size on the pharmacokinetics of lamotrigine, and assess the dose rationale across different age groups from 0.2 to 91 years. METHODS: An allometrically scaled pharmacokinetic model was developed using adolescent and adult data, taking into account the effect of comedications. Model parameters were then used to extrapolate lamotrigine pharmacokinetics to older adults (> 65 years), children (4-12 years) and infants and toddlers (0...
January 23, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29356816/association-of-exposure-to-communities-with-higher-ratios-of-obesity-with-increased-body-mass-index-and-risk-of-overweight-and-obesity-among-parents-and-children
#14
Ashlesha Datar, Nancy Nicosia
Importance: Little is known about whether the substantial clustering of obesity and overweight within social and geographic networks results from causal pathways, such as social contagion and shared environments, or from self-selection. Objectives: This study aimed to determine whether exposure to communities with higher rates of obesity increases the body mass index (BMI) of individuals, calculated as weight in kilograms divided by height in meters squared, and their risk of being overweight or obese, and whether social contagion, shared environments, or self-selection can account for identified differences...
January 22, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29345088/retraction
#15
(no author information available yet)
'The association of hypotension with the insertion of an abdominal retractor during lower abdominal surgery in pediatric patients: a retrospective observational study' by Rika Nakayama, Takahiro Mihara, Yoshihisa Miyamoto & Koui Ka.1 The above article from Pediatric Anesthesia, published online on July 7, 2015 in Wiley Online Library (http://wileyonlinelibrary.com) has been retracted by agreement between the authors, the Journal Editor in Chief, Andrew Davidson, and John Wiley & Sons Ltd. The retraction has been agreed following a review of the study data by the authors, which found that cases not satisfying the inclusion criteria were included and that there were data collection errors with respect to the patients' ages and sexes...
February 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29329029/corrigendum-to-pharmacological-profile-of-dexketoprofen-in-orofacial-pain-pharmacol-rep-68-6-2016-1111-1114
#16
Hugo F Miranda, Fernando Sierralta, Nicolás Aranda, Viviana Noriega, Juan Carlos Prieto
No abstract text is available yet for this article.
January 9, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29313889/inventing-new-therapies-without-reinventing-the-wheel-the-power-of-drug-repurposing
#17
EDITORIAL
Andreas Papapetropoulos, Csaba Szabo
This article is part of a themed section on Inventing New Therapies Without Reinventing the Wheel: The Power of Drug Repurposing. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.2/issuetoc.
January 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29285771/endotoxemia-rocks-sphingolipid-metabolism-at-the-blood-brain-barrier-an-editorial-highlight-for-alteration-of-sphingolipid-metabolism-as-a-putative-mechanism-underlying-lps-induced-bbb-disruption-on-doi-10-1111-jnc-14236
#18
Eric Camerer
In this issue of the Journal of Neurochemistry, Vutukuri et al. evaluate the impact of endotoxemia-induced encephalopathy on the sphingosine-1-phosphate (S1P) signaling pathway at the blood-brain barrier (BBB). Four hours after intraperitoneal administration of lipopolysaccharides (LPS, 4 mg/kg) to mice, they first demonstrate BBB dysfunction and then evaluate changes in sphingolipid metabolites in serum, isolated brain microvessels (MBMV), and whole brain. In parallel, they investigate the fate of indicated S1P generating and metabolizing enzymes and S1P receptors in brain and MBMV...
December 28, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29282082/associations-between-dietary-factors-and-obesity-related-biomarkers%C3%A2-in-healthy-children-and-adolescents-a-systematic-review
#19
REVIEW
Jennifer Hilger-Kolb, Catherin Bosle, Irina Motoc, Kristina Hoffmann
BACKGROUND: The obesity prevalence in children and adolescents has increased worldwide during the past 30 years. Although diet has been identified as one risk factor for developing obesity in this age group, the role of specific dietary factors is still unclear. One way to gain insight into the role of these factors might be to detect biomarkers that reflect metabolic health and to identify the associations between dietary factors and these biomarkers. This would enable nutrition-related metabolic changes to be detected early in life, which might be a promising strategy to prevent childhood obesity...
December 28, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/29250778/news-isn-december-2017
#20
(no author information available yet)
The 2016 Mark Smith Award winner is Sunmin Jung (Seoul National University), for the pa per Dual-specificity phosphatase 26 (DUSP26) stimulates Aβ42 generation by promoting amyloid precursor protein axonal transport during hypoxia. Journal of Neurochemistry (2016) 137(5): 770-781, Sunmin Jung, Jihoon Nah, Jonghee Han, Seon-Guk Choi, Hyunjoo Kim, Jaesang Park, Ha-Kyung Pyo, Yong-Keun Jung. https://doi.org/10.1111/jnc.13597.
December 18, 2017: Journal of Neurochemistry
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