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REVIEW
Idir Ouzaid, Nathalie Rioux-Leclercq, Zine-Eddine Khene, Karim Bensalah, Solène-Florence Kammerer-Jacquet
CONTEXT: The advent of immune check inhibitors (ICIs) has tremendously changed the prognosis of metastatic renal cell carcinoma (mRCC), adding an unseen substantial overall survival benefit. These agents could be administered alone or in combination with anti-vascular endothelial growth factor (anti-VEGF) therapies. So far, treatment allocation is based only on clinical stratification risk models. OBJECTIVE: Herein, we aimed to report the different molecular classifications reported in the first-line treatment of mRCC and discuss the awaited clinical implications in terms of treatment selection...
January 2023: European urology open science
#22
REVIEW
Shima Heidari, Hossein Khalili
OBJECTIVES: To summarize the pharmacokinetics of linezolid to optimize the dosing regimen in special populations. METHODS: A literature search was performed in three largest medical databases, including Embase, Scopus, and PubMed. The main applied keywords were linezolid and pharmacokinetics. Of 3663 retrieved publications in the English language, 35 original research articles, clinical studies, and case reports about linezolid pharmacokinetics in different populations such as pregnant women, pediatrics, elderly subjects, obese people, individuals with organ dysfunction, and critically ill patients were included...
February 2023: European Journal of Clinical Pharmacology
#23
JOURNAL ARTICLE
Toktam Alirezaei, Mir Jafar Jebreil Moosavi, Rana Irilouzadian, Elahe Taziki
Background: Intradialytic hypotension (IDH) has been recognized as a serious and frequent complication during hemodialysis (HD) of end-stage renal disease (ESRD) patients, but the effect of asymptomatic IDH on cardiac troponin I (cTnI) levels is not definitively elucidated. Methods: 70 asymptomatic HD patients with negative predialysis cTnI were included. They were on maintenance HD thrice weekly. All patients were monitored during the HD session for hemodynamic changes and symptoms related to IDH...
2022: International Journal of Clinical Practice
#24
REVIEW
Shanti Ranjan Sanyal, Ankur Arora, Amin Nisreen, Khattab Mohamed, Saeed Kilani Mohammad, Deb Baruah
Management of urological malignancies has evolved significantly with continually changing guidelines and treatment options which demand more centralized involvement of radiology than ever before. Radiologists play a pivotal role in interpreting complex cancer scans and guiding clinical teams toward the best management options in the light of clinical profile. Management of complex uro-oncology cases is often discussed in multidisciplinary meetings which are essential checkpoints to evaluate an overall picture and formulate optimal treatment plans...
June 2022: Indian Journal of Radiology & Imaging
#25
JOURNAL ARTICLE
Feray Gencer Bingol, Hilal Yildiran, Yasemin Erten, Emre Yasar
INTRODUCTION: Nutrition in hemodialysis patients is important in decreasing complications, improving quality of life, and preventing of malnutrition. Recommendations of the guidelines are taken into consideration while prescribing a nutrition therapy plan for patients. However, the recommendations may differ between the guidelines. It was aimed to compare the newly published National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI) guideline with previous reported two guideline recommendations and protein energy wasting criteria in this study...
July 2022: Néphrologie & Thérapeutique
#26
JOURNAL ARTICLE
Javier Naranjo, Mónica Furlano, Ferran Torres, Jonathan Hernandez, Marc Pybus, Laia Ejarque, Christian Cordoba, Lluis Guirado, Elisabet Ars, Roser Torra
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease and shows a wide phenotype. Only patients with rapid progression (RP) are included in clinical trials or are approved to receive disease-modifying drugs. This study aims at comparing different available predictive tools in ADPKD with the Mayo classification (MC) identification of rapid progressors based on high total kidney volume (TKV) according to age. METHODS: A total of 164 ADPKD patients were recruited retrospectively from a single centre...
May 2022: Clinical Kidney Journal
#27
JOURNAL ARTICLE
Raymond Vanholder, John Agar, Marion Braks, Daniel Gallego, Karin G F Gerritsen, Mark Harber, Edita Noruisiene, Jitka Pancirova, Giorgina B Piccoli, Dimitrios Stamatialis, Fokko Wieringa
The world faces a dramatic man-made ecologic disaster and healthcare is a crucial part of this problem. Compared with other therapeutic areas, nephrology care, and especially dialysis, creates an excessive burden via water consumption, greenhouse gas emission and waste production. In this advocacy article from the European Kidney Health Alliance we describe the mutual impact of climate change on kidney health and kidney care on ecology. We propose an array of measures as potential solutions related to the prevention of kidney disease, kidney transplantation and green dialysis...
May 4, 2023: Nephrology, Dialysis, Transplantation
#28
JOURNAL ARTICLE
Sara Medved, Nikola Žaja, Gabor Gazdag, Aiste Lengvenyte, Sabrina Mörkl, Federico Mucci, Ivan Ristić, Stefan Jerotić, Johannes Frederik Regente, Iva Ivanović, Anela Purišić, Ferdinand Sasvary, Vimal Sivasanker, Alper Ziblak, Margus Lookene, Pascal Sienaert, Anna Szczegielniak, Pavel Trančik, Elvir Bećirović, Theodoros Koutsomitros, Giovanni Grech, Cristiana Tapoi, Branimir Radmanović, Andreas Ströhle, Maja Bajs Janović, Norman Sartorius
OBJECTIVES: Pre-electroconvulsive therapy (ECT) evaluation is an essential part of ECT preparation, a standard treatment in the psychiatric field. However, no routine pre-ECT evaluation has been published so far. This preliminary study aimed to explore different practices in pre-ECT evaluation across European countries. METHODS: The data were collected as a snowball sample approach using an online survey from September 2019 to April 2020. The final analysis included data from 18 clinics placed in 16 European countries...
December 1, 2022: Journal of ECT
#29
Matthew Smith, Shoba Dawson, Robert C Andrews, Sofia H Eriksson, Hugh Selsick, Andrew Skyrme-Jones, Udaya Udayaraj, Jonathan Rees, Edward Strong, Emily J Henderson, Marcus J Drake
Patients with nocturia are commonly referred to urology clinics, including many for whom a nonurological medical condition is responsible for their symptoms. The PLanning Appropriate Nocturia Evaluation and Treatment (PLANET) study was established to develop practical approaches to equip healthcare practitioners to deal with the diverse causes of nocturia, based on systematic reviews and expert consensus. Initial assessment and therapy need to consider the possibility of one or more medical conditions falling into the "SCREeN" areas of Sleep medicine (insomnia, periodic limb movements of sleep, parasomnias, and obstructive sleep apnoea), Cardiovascular (hypertension and congestive heart failure), Renal (chronic kidney disease), Endocrine (diabetes mellitus, thyroid disease, pregnancy/menopause, and diabetes insipidus), and Neurology...
January 2022: European Urology Focus
#30
JOURNAL ARTICLE
Qianyi Peng, Lina Zhang, Meilin Ai, Li Huang, Yuhang Ai
OBJECTIVES: Sepsis associated encephalopathy (SAE) is a common neurological complication of sepsis. Delirium is a common symtom of SAE. The pathophysiology of SAE is still unclear, but several likely mechanisms have been proposed, such as mitochondrial and endothelial dysfunction, neurotransmission disturbances, derangements of calcium homeostasis, cerebral microcirculation dysfunction, and brain hypoperfusion. Near-infrared spectroscopy (NIRS) is a non-invasive measure for regional cerebral oxygen saturation (rSO2 ), which has attracted more attention these years...
November 28, 2021: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
#31
EDITORIAL
Cecilia Becattini, Valentin A Kokorin, Wiktoria Lesniak, Ignacio Marin-Leon, Francisco J Medrano, Laura Morbidoni, Alberto M Marra, Ewelina Biskup, Antoni Riera-Mestre, Dror Dicker
BACKGROUND: Several trials have been conducted in the last decades that challenged the management of patients with acute pulmonary embolism (PE) in terms of diagnosis and treatment. Updated international clinical practice guidelines (CPGs) endorsed the evidence from these trials. The aim of this document was to adapt recommendations from existing CPGs to assist physicians in decision making concerning specific and complex scenarios related to acute PE. METHODS: The flow for the adaptation procedure was first the identification of unsolved clinical issues in patients with acute PE (PICOs), then critically appraise the existing CPGs and choose the recommendations, which are the most applicable to these specific and complex scenarios...
February 2022: European Journal of Internal Medicine
#32
REVIEW
Guohua Zeng, Zhijian Zhao, Giorgio Mazzon, Margaret Pearle, Simon Choong, Andreas Skolarikos, John Denstedt, Christian Seitz, Daniel Olvera Pasada, Cristian Fiori, Andrea Bosio, Athanasios Papatsoris, Carlos Enrique Méndez Probst, Daniel Perez Fentes, Kah Ann Git, Qinghui Wu, Oliver Wiseman, Esteban Emiliani, Yasser Farahat, Mehmet Ilker Gökce, Stilianos Giannakopoulos, Ioannis Goumas Kartalas, Bhaskar Somani, Thomas Knoll, Jean de la Rosette, Jiehui Zhong, Marcus Vinicius Maroccolo, Lliya Saltirov, Ben Chew, Kunjie Wang, Sven Lahme, Guido Giusti, Stefania Ferretti, Sung Yong Cho, Petrisor Geavlete, Ramon Cansino, Guido M Kamphuis, Daron Smith, Brian R Matlaga, Khurshid D Ghani, Norberto Bernardo, Andres D Silva, Anthony C F Ng, Sixing Yang, Xiaofeng Gao, Olivier Traxer, Arkadiusz Miernik, Evangelos Liatsikos, Kandarp Priyakant Parikh, Mordechai Duvdevani, Antonio Celia, Takahiro Yasui, Albert Aquino, Mohammad Alomar, Vorapot Choonhaklai, Bulent Erkurt, Jonathan Glass, Seshadri Sriprasad, Palle J Osther, Francis X Keeley, Glenn M Preminger, Marcos Cepeda Delgado, Edgar Beltran Suarez, Zhangqun Ye, Kemal Sarica
BACKGROUND: Retrograde intrarenal surgery (RIRS) has become the preferred treatment modality for nephrolithiasis. However, because of ongoing uncertainties regarding the optimal perioperative management, operative technique, and postoperative follow-up, as well as a lack of standardization for outcome reporting, consensus is needed to achieve more uniform clinical practice worldwide. OBJECTIVE: To develop recommendations for RIRS on the basis of existing data and expert consensus...
September 2022: European Urology Focus
#33
REVIEW
Ricardo Gómez-Huelgas, Jaime Sanz-Cánovas, Lidia Cobos-Palacios, Almudena López-Sampalo, Luis M Pérez-Belmonte
Findings from cardiovascular outcome trials on certain newer glucose-lowering drugs have shown clear cardiovascular and renal benefits. In this review, we provide an updated overview of glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter 2 (SGLT-2) inhibitors in terms of cardiovascular and renal protection. Both drugs have been described as diabetes/disease-modifying drugs. There is robust evidence on the benefits of GLP-1 receptor agonists in renal disease and atherosclerotic cardiovascular disease-especially in stroke-which are mainly explained by their antiproteinuric effect...
February 2022: European Journal of Internal Medicine
#34
JOURNAL ARTICLE
Laura Groseanu, Sorana Petrescu, Andra Balanescu, Violeta Bojinca, Daniela Opris-Belinski, Florian Berghea, Diana Mazilu, Ioana Saulescu, Andreea Borangiu, Sanziana Daia-Iliescu, Cosmin Constantinescu, Claudia Cobilinschi, Mihai Abobului, Maria Magdalena Negru, Ruxandra Ionescu
BACKGROUND: No fully validated index is available for assessing overall disease activity in systemic sclerosis (SSc). OBJECTIVES: To estimate the effect of disease activity as measured by different disease activity indices on the risk of subsequent organ damage. METHODS: The European Systemic sclerosis study group activity index (EScSG AI), the European Scleroderma Trials and Research Group Activity Index (r-EUSTAR AI), 12 point activity index proposed by Minier (12point AI) were calculated for 91 patients; the CRISS (The Composite Response Index for Systemic Sclerosis) for patients included after 2016...
2022: Current Rheumatology Reviews
#35
REVIEW
Amalia Leceta, Aintzane García, Ander Sologuren, Cristina Campo
BACKGROUND: Bilastine, a non-sedating H1 -antihistamine, is indicated to treat the symptoms of allergic disorders (e.g. rhinoconjunctivitis and urticaria) in adults and adolescents and, more recently, in children. Following its marketing approval, many questions regarding the ideal use of bilastine in various clinical practice situations have been received by the Medical Information Department (MID) of Faes Farma Spain. This article is an update of a previous review, with a focus on recent clinical information on the use of bilastine in paediatric and other populations...
2021: Drugs in Context
#36
REVIEW
John William McEvoy, Catriona Jennings, Kornelia Kotseva, Guy De Backer, Dirk De Bacquer, Iris Erlund, Gregory Y H Lip, Kausik K Ray, Lars Rydén, Agnieszka Adamska, David A Wood
PURPOSE OF REVIEW: To describe the INTERASPIRE scientific protocol-an international survey of secondary prevention of coronary heart disease (CHD). RECENT FINDINGS: This international survey is being conducted through National Societies of Cardiology in selected countries from each of the six WHO regions and has the following overall aims: (i) describe prevalence of cardiometabolic and renal risk factors together with biomarkers in CHD patients; (ii) describe current risk factor management through lifestyle changes and cardioprotective drug therapies; (iii) provide an objective assessment of clinical implementation of preventive care by comparison with the lifestyle and risk factor targets defined in international and national guidelines; (iv) investigate the reasons for variation in preventive cardiology practice between regions and countries; and (v) promote the principles of best preventive cardiology practice...
August 19, 2021: Current Cardiology Reports
#37
JOURNAL ARTICLE
Victor Aboyans, Rupert Bauersachs, Lucia Mazzolai, Marianne Brodmann, José F Rodriguez Palomares, Sebastian Debus, Jean-Philippe Collet, Heinz Drexel, Christine Espinola-Klein, Basil S Lewis, Marco Roffi, Dirk Sibbing, Henrik Sillesen, Eugenio Stabile, Oliver Schlager, Marco De Carlo
The aim of this collaborative document is to provide an update for clinicians on best antithrombotic strategies in patients with aortic and/or peripheral arterial diseases. Antithrombotic therapy is a pillar of optimal medical treatment for these patients at very high cardiovascular risk. While the number of trials on antithrombotic therapies in patients with aortic or peripheral arterial diseases is substantially smaller than for those with coronary artery disease, recent evidence deserves to be incorporated into clinical practice...
October 14, 2021: European Heart Journal
#38
JOURNAL ARTICLE
Yang Xu, Marie Evans, Peter Barany, Glen James, Arvid Sjölander, Juan Jesus Carrero
BACKGROUND: Attaining the narrow haemoglobin (Hb) range recommended by European Renal Best Practice Guidelines renal anaemia guidelines may be difficult, and whether this leads to better outcomes following dialysis initiation is not known. METHODS: This was an observational study from the Swedish Renal Registry 2012-16, including all patients with non-dialysis-dependent chronic kidney disease (CKD) initiating renal anaemia treatment. We evaluated factors associated with off-target Hb attainment (<10 and >12 g/dL)...
July 2021: Clinical Kidney Journal
#39
JOURNAL ARTICLE
Lidia Remolí Sargues, Javier Montero Hernández, Miguel Ortiz Salvador, Baltasar Moratal Peiro, Clara Monferrer Adsuara, Verónica Castro Navarro, Catalina Navarro Palop, Enrique Cervera Taulet
PURPOSE: To report a case of vitamin A retinopathy secondary to Billroth II anastomosis triggered after the beginning of dialysis in a patient with a chronic renal failure. CASE REPORT: A 73-year-old male complained of nyctalopia that had started 9 months ago, coinciding with the beginning of dialysis. His medical history is remarkable for hepatic cirrhosis and Billroth II anastomosis 20 years ago. Best-corrected visual acuity (BCVA) was 60 letters in both eyes...
November 2022: European Journal of Ophthalmology
#40
JOURNAL ARTICLE
Francesco Trepiccione, Steven B Walsh, Gema Ariceta, Olivia Boyer, Francesco Emma, Roberta Camilla, Pietro Manuel Ferraro, Dieter Haffner, Martin Konrad, Elena Levtchenko, Sergio Camilo Lopez-Garcia, Fernando Santos, Stella Stabouli, Maria Szczepanska, Velibor Tasic, Rezan Topaloglu, Rosa Vargas-Poussou, Tanja Wlodkowski, Detlef Bockenhauer
Distal renal tubular acidosis (dRTA) is characterized by an impaired ability of the distal tubule to excrete acid, leading to metabolic acidosis. Associated complications include bone disease, growth failure, urolithiasis and hypokalaemia. Due to its rarity, there is limited evidence to guide diagnosis and management; however, available data strongly suggest that metabolic control of the acidosis by alkali supplementation can halt or revert almost all complications. Despite this, cohort studies show that adequate metabolic control is present in only about half of patients, highlighting problems with treatment provision or adherence...
August 27, 2021: Nephrology, Dialysis, Transplantation
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