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https://www.readbyqxmd.com/read/28650319/somatostatin-binds-to-the-human-amyloid-%C3%AE-peptide-and-favors-the-formation-of-distinct-oligomers
#1
Hansen Wang, Lisa D Muiznieks, Punam Ghosh, Declan Williams, Michael Solarski, Andrew Fang, Alejandro Ruiz-Riquelme, Régis Pomès, Joel C Watts, Avi Chakrabartty, Holger Wille, Simon Sharpe, Gerold Schmitt-Ulms
The amyloid β peptide (Aβ) is a key player in the etiology of Alzheimer disease (AD), yet a systematic investigation of its molecular interactions has not been reported. Here we identified by quantitative mass spectrometry proteins in human brain extract that bind to oligomeric Aβ1-42 (oAβ1-42) and/or monomeric Aβ1-42 (mAβ1-42) baits. Remarkably, the cyclic neuroendocrine peptide somatostatin-14 (SST14) was observed to be the most selectively enriched oAβ1-42 binder. The binding interface comprises a central tryptophan within SST14 and the N-terminus of Aβ1-42...
June 26, 2017: ELife
https://www.readbyqxmd.com/read/28648200/-what-place-does-old-age-hold-in-our-society
#2
Régis Aubry, Cynthia Fleury-Perkins
Ageing is often the subject of denial in our societies. In addition to the over-medicalisation of elderly people there is also a certain form of exclusion, or even contempt. Elderly people remind us all that life is relative and of our own mortality. What can be done to ensure that old age is considered differently?
June 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28646324/expression-purification-and-characterization-of-gmz2-10c-a-complex-disulphide-bonded-fusion-protein-vaccine-candidate-against-the-asexual-and-sexual-life-stages-of-the-malaria-causing-plasmodium-falciparum-parasite
#3
Ulrik H Mistarz, Susheel K Singh, Tam T T N Nguyen, Will Roeffen, Fen Yang, Casper Lissau, Søren M Madsen, Astrid Vrang, Régis W Tiendrebeogo, Ikhlaq H Kana, Robert W Sauerwein, Michael Theisen, Kasper D Rand
PURPOSE: Production and characterization of a chimeric fusion protein (GMZ2'.10C) which combines epitopes of key malaria parasite antigens: glutamate-rich protein (GLURP), merozoite surface protein 3 (MSP3), and the highly disulphide bonded Pfs48/45 (10C). GMZ2'.10C is a potential candidate for a multi-stage malaria vaccine that targets both transmission and asexual life-cycle stages of the parasite. METHODS: GMZ2'.10C was produced in Lactococcus lactis and purified using either an immunoaffinity purification (IP) or a conventional purification (CP) method...
June 23, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28641709/cystic-fibrosis-current-aspects-and-perspectives
#4
EDITORIAL
Pierre-Régis Burgel, Isabelle Fajac
No abstract text is available yet for this article.
June 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28640022/brain-dead-donors-on-extracorporeal-membrane-oxygenation
#5
Régis Bronchard, Louise Durand, Camille Legeai, Johana Cohen, Patrice Guerrini, Olivier Bastien
OBJECTIVES: To describe donors after brain death with ongoing extracorporeal membrane oxygenation and to analyze the outcome of organs transplanted from these donors. DESIGN: Retrospective analysis of the national information system run by the French Biomedicine Agency (CRISTAL database). SETTING: National registry data of all donors after brain death in France and their organ recipients between 2007 and 2013. PATIENTS: Donors after brain death and their organ recipients...
June 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28639375/challenges-in-regenerating-the-diabetic-heart-a-comprehensive-review
#6
REVIEW
Venkata R Satthenapalli, Regis R Lamberts, Rajesh Katare
Stem cell therapy is one of the promising regenerative strategies developed to improve cardiac function in patients with ischemic heart diseases (IHD). However, this approach is limited in IHD patients with diabetes due to a progressive decline in the regenerative capacity of stem cells. This decline is mainly attributed to the metabolic memory incurred by diabetes on stem cell niche and their systemic cues. Understanding the molecular pathways involved in the diabetes-induced deterioration of stem cell function will be critical for developing new cardiac regeneration therapies...
June 22, 2017: Stem Cells
https://www.readbyqxmd.com/read/28634760/thiago-regis-longo-cesar-da-paix%C3%A3-o-and-subrayal-m-reddy-eds-materials-for-chemical-sensing
#7
Marco Giannetto
No abstract text is available yet for this article.
June 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28633393/outcomes-of-palliative-right-ventricle-to-pulmonary-artery-connection-for-pulmonary-atresia-with-ventricular-septal-defect%C3%A2
#8
Marien Lenoir, Margaux Pontailler, Régis Gaudin, Sébastien Gerelli, Daniel Tamisier, Damien Bonnet, Bari Murtuza, Pascal R Vouhé, Olivier Raisky
OBJECTIVES: To determine the early, intermediate and long-term outcomes of pulmonary atresia with ventricular septal defect (PA/VSD) Types I, II and III initially palliated by a right ventricle to pulmonary artery (RVPA) connection. METHODS: We performed a retrospective study from 2000 to 2014 that included 109 patients with PA/VSD who had undergone an RVPA connection (tetralogy of Fallot and PA/VSD Type IV excluded). The end-points of this strategy were adequate pulmonary artery tree post-palliation, second palliation, biventricular repair, right ventricular pressure post-biventricular repair and late reoperation...
June 15, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28632414/changing-us-population-demographics-what-does-this-mean-for-listeriosis-incidence-and-exposure
#9
Aurelie M Pohl, Régis Pouillot, Jane M Van Doren
Listeria monocytogenes is an important cause of foodborne illness hospitalization, fetal loss, and death in the United States. Listeriosis incidence rate varies significantly among population subgroups with pregnant women, older persons, and the Hispanic population having increased relative risks compared with the other subpopulations. Using estimated rates of listeriosis per subpopulation based on FoodNet data from 2004 to 2009, we evaluate the expected number of cases and incidence rates of listeriosis in the US population and the pregnant women subpopulation as the demographic composition changes over time with respect to ethnicity, pregnancy status, and age distribution...
June 20, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28627189/-nitrogenous-content-in-parenteral-nutrition-a-four-year-experience-in-a-general-hospital-critically-ill-patient-specificity
#10
Juan Luis Villalobos-Gámez, Carlos Lara-Ramos, Yolanda Domínguez-Rivas, Antonio Vallejo-Báez, Francisco Cota-Delgado, Efrén Márquez-Fernández, José Manuel García-Almeida, José Antonio López-Medina, Rosalía Rioja-Vázquez, Albert Santacreu-Regí, Francisca Rius-Díaz, Alfredo Mínguez-Mañanes
INTRODUCTION: There have been several studies focusing on caloric intake during the last years, while protein content relevance has been underestimated. Some recent evidence has shown that protein deficiency has also an impact on patient outcomes. We have studied the nitrogen (N) content in parenteral nutrition (PN) bags administered to adult patients in a Spanish tertiary level hospital for four years. MATERIAL AND METHODS: Patients who received parenteral nutrition in the general ward and Intensive Care Unit (ICU) were recorded...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28625934/evaluation-of-the-quality-of-medical-certificates-in-the-context-of-the-opening-of-a-measure-of-legal-protection-for-adults-over-60-years-of-age
#11
Guillaume Arcese, Olivier Drunat, Sylvie Arbault, Régis Gonthier
In France between 700,000 and 800,000 people will be covered by legal protection. The opening of any measure is conditioned by a detailed medical certificate. It is drawn up by a doctor registered on the list drawn up by the public prosecutor. No specific training is required. A single piece of legislation frames the content of the certificates. We therefore investigated whether the medical certificates currently produced were in compliance with the code of civil procedure. 111 medical certificates collected and anonymized by the tribunal d'instance of Saint-Étienne, from 4 January to 3 April 2016...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28619055/molecular-typing-of-leptospira-interrogans-serovar-hardjo-isolates-from-leptospirosis-outbreaks-in-brazilian-livestock
#12
Maria Raquel V Cosate, Tetsu Sakamoto, Tiago Antônio de Oliveira Mendes, Élvio C Moreira, Carlos G Regis da Silva, Bruno S A F Brasil, Camila S F Oliveira, Vasco Ariston de Azevedo, José Miguel Ortega, Rômulo C Leite, João Paulo Haddad
BACKGROUND: Leptospirosis is caused by pathogenic spirochetes of the genus Leptospira spp. This zoonotic disease is distributed globally and affects domestic animals, including cattle. Leptospira interrogans serogroup Sejroe serovar Hardjo and Leptospira borgpetersenii serogroup Sejroe serovar Hardjo remain important species associated with this reproductive disease in livestock production. Previous studies on Brazilian livestock have reported that L. interrogans serovar Hardjo is the most prevalent leptospiral agent in this country and is related to clinical signs of leptospirosis, which lead to economic losses in production...
June 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28614858/concept-of-combined-femoral-and-tibial-osteotomies
#13
Dominique Saragaglia, Loic Sigwalt, Brice Rubens-Duval, Billy Chedal-Bornu, Regis Pailhe
No abstract text is available yet for this article.
June 14, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28614801/dna-methyltransferase-3b-regulates-articular-cartilage-homeostasis-by-altering-metabolism
#14
Jie Shen, Cuicui Wang, Daofeng Li, Taotao Xu, Jason Myers, John M Ashton, Ting Wang, Michael J Zuscik, Audrey McAlinden, Regis J O'Keefe
Osteoarthritis (OA) is the most common form of arthritis worldwide. It is a complex disease affecting the whole joint but is generally characterized by progressive degradation of articular cartilage. Recent genome-wide association screens have implicated distinct DNA methylation signatures in OA patients. We show that the de novo DNA methyltransferase (Dnmt) 3b, but not Dnmt3a, is present in healthy murine and human articular chondrocytes and its expression decreases in OA mouse models and in chondrocytes from human OA patients...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28614501/the-group-oral-health-movement-in-brazil
#15
Catharina Leite Matos Soares, Jairnilson Silva Paim, Sonia Cristina de Lima Chaves, Thais Regis Aranha Rossi, Sandra Garrido Barros, Denise Nogueira Cruz
Group Oral Health (GOH) is a specific phenomenon in time, separate from other "Alternative Odontology", and a theoretical reference for dental practice in healthcare services. This study is an attempt to understand how long "Alternative Odontology" will remain with the social context of struggling for oral health in Brazil, based on the positions of the founding agents and their precursors, bearing in mind the concepts of GOH, GH (Group Health) and the SUS (Unified Healthcare System). We started out with Pierre Bourdieu's Practice Theory, complemented with Gramsci's concept of hegemony and counter-hegemony...
June 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28614500/oral-health-policy-in-brazil-between-2003-and-2014-scenarios-proposals-actions-and-outcomes
#16
Sônia Cristina Lima Chaves, Ana Maria Freire de Lima Almeida, Thaís Regis Aranha Rossi, Sisse Figueiredo de Santana, Sandra Garrido de Barros, Carla Maria Lima Santos
This study examined the implementation of Brazil's National Oral Health Policy by the three governments during the period 2003 to 2014. It provides a general overview of oral health care scenarios and examines institutional proposals and actions developed by the executive branch based on the components of the health care system. A documental analysis was conducted using documents produced by key government agencies. The findings show that there was an increase in the provision and coverage of public dental services between 2003 and 2006 and that rates were maintained to a certain degree in subsequent periods (2007 to 2010 and 2011 to 2014)...
June 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28610632/erratum-to-liver-morphometrics-and-metabolic-blood-profile-across-divergent-phenotypes-for-feed-efficiency-in-the-bovine
#17
Yuri Regis Montanholi, Livia Sadocco Haas, Kendall Carl Swanson, Brenda Lynn Coomber, Shigeto Yamashiro, Stephen Paul Miller
No abstract text is available yet for this article.
June 13, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28610334/morphological-description-of-early-zoeal-stages-of-alpheus-brasileiro-anker-2012-reared-in-the-laboratory-including-a-revision-of-the-larval-morphology-of-the-first-zoeal-stage-of-the-genus-alpheus-fabricius-1798-caridea-alpheidae
#18
Régis A Pescinelli, João A F Pantaleão, Fernando L Mantelatto, Rogério C Costa
The aims of this study were to describe and illustrate the early larval stages of the snapping shrimp Alpheus brasileiro Anker, 2012 and to review the larval morphology (Zoea I) of the genus Alpheus Fabricius, 1798. Larvae were obtained from two females with embryos collected in an intertidal estuary in Cananéia, São Paulo state, Brazil. The published descriptions of all available Alpheus zoea I (only 14 spp., 4.7%) were used for a comparison of larval morphology. The zoeae I of Alpheus species are very similar, but A...
May 22, 2017: Zootaxa
https://www.readbyqxmd.com/read/28608327/diffusional-kurtosis-imaging-dki-incorporation-into-an-intravoxel-incoherent-motion-ivim-mr-model-to-measure-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-in-healthy-subjects
#19
Aude Pavilla, Giulio Gambarota, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Hervé Saint-Jalmes
OBJECTIVES: The objectives were to investigate the diffusional kurtosis imaging (DKI) incorporation into the intravoxel incoherent motion (IVIM) model for measurements of cerebral hypoperfusion in healthy subjects. MATERIALS AND METHODS: Eight healthy subjects underwent a hyperventilation challenge with a 4-min diffusion weighted imaging protocol, using 8 b values chosen with the Cramer-Rao Lower Bound optimization approach. Four regions of interest in gray matter (GM) were analyzed with the DKI-IVIM model and the bi-exponential IVIM model, for normoventilation and hyperventilation conditions...
June 12, 2017: Magma
https://www.readbyqxmd.com/read/28607914/reconstitution-of-adaptive-immunity-after-umbilical-cord-blood-transplantation-impact-on-infectious-complications
#20
REVIEW
Sophie Servais, Muriel Hannon, Régis Peffault de Latour, Gérard Socie, Yves Beguin
In comparison with allogeneic stem cell transplantation (alloHSCT) with other stem cell sources, umbilical cord blood transplantation (UCBT) was traditionally associated with increased risk of infections, particularly during the first 3 months after transplantation. Longitudinal studies of immune monitoring reported peculiar patterns of T- and B-cell recovery in the peripheral blood of UCB recipients during the first months post-transplantation. Overall, current data suggest delayed reconstitution of naive and memory CD4(+) and CD8(+) T-cell pools after UCBT...
2017: Stem Cell Investigation
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