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https://www.readbyqxmd.com/read/29028988/quasar-mpra-accurate-allele-specific-analysis-for-massively-parallel-reporter-assays
#1
Cynthia A Kalita, Gregory A Moyerbrailean, Christopher Brown, Xiaoquan Wen, Francesca Luca, Roger Pique-Regi
Motivation: The majority of the human genome is composed of non-coding regions containing regulatory elements such as enhancers, which are crucial for controlling gene expression. Many variants associated with complex traits are in these regions, and may disrupt gene regulatory sequences. Consequently, it is important to not only identify true enhancers but also to test if a variant within an enhancer affects gene regulation. Recently, allele-specific analysis in high-throughput reporter assays, such as massively parallel reporter assays (MPRA), have been used to functionally validate non-coding variants...
September 22, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29027320/trends-in-oncoplastic-breast-surgery-and-breast-reconstruction-over-the-past-35%C3%A2-years
#2
Ruffo Freitas-Junior, Sara Socorro Faria, Régis Resende Paulinelli, Edésio Martins
No abstract text is available yet for this article.
October 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/29026302/ultrasmall-aguix-theranostic-nanoparticles-for-vascular-targeted-interstitial-photodynamic-therapy-of-glioblastoma
#3
Eloïse Thomas, Ludovic Colombeau, Mickaël Gries, Thibaut Peterlini, Clélia Mathieu, Noémie Thomas, Cédric Boura, Céline Frochot, Régis Vanderesse, François Lux, Muriel Barberi-Heyob, Olivier Tillement
Despite combined treatments, glioblastoma outcome remains poor with frequent local recurrences, indicating that a more efficient and local therapy is needed. In this way, vascular-targeted photodynamic therapy (VTP) could help tumor eradication by destroying its neovessels. In this study, we designed a polysiloxane-based nanoparticle (NP) combining a magnetic resonance imaging (MRI) contrast agent, a photosensitizer (PS) and a new ligand peptide motif (KDKPPR) targeting neuropilin-1 (NRP-1), a receptor overexpressed by angiogenic endothelial cells of the tumor vasculature...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29024060/loss-of-dnmt3b-in-chondrocytes-leads-to-delayed-endochondral-ossification-and-fracture-repair
#4
Cuicui Wang, Yousef Abu-Amer, Regis J O'Keefe, Jie Shen
Despite advanced understanding of signaling mediated by local and systemic factors, the role of epigenetic factors in the regulation of bone regeneration remains vague. The DNA methyltransferases (Dnmts) Dnmt3a and Dnmt3b have tissue specific expression patterns and create unique methylation signatures to regulate gene expression. Using a stabilized murine tibia fracture model we find that Dnmt3b is induced early in fracture healing, peaks at 10 days post fracture (dpf), and declines to nearly undetectable levels by 28 dpf...
October 10, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29023442/environmental-perturbations-lead-to-extensive-directional-shifts-in-rna-processing
#5
Allison L Richards, Donovan Watza, Anthony Findley, Adnan Alazizi, Xiaoquan Wen, Athma A Pai, Roger Pique-Regi, Francesca Luca
Environmental perturbations have large effects on both organismal and cellular traits, including gene expression, but the extent to which the environment affects RNA processing remains largely uncharacterized. Recent studies have identified a large number of genetic variants associated with variation in RNA processing that also have an important role in complex traits; yet we do not know in which contexts the different underlying isoforms are used. Here, we comprehensively characterized changes in RNA processing events across 89 environments in five human cell types and identified 15,300 event shifts (FDR = 15%) comprised of eight event types in over 4,000 genes...
October 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29022167/stochastic-evaluation-of-annual-micropollutant-loads-and-their-uncertainties-in-separate-storm-sewers
#6
Ali Hannouche, Ghassan Chebbo, Claude Joannis, Johnny Gasperi, Marie-Christine Gromaire, Régis Moilleron, Sylvie Barraud, Véronique Ruban
This article describes a stochastic method to calculate the annual pollutant loads and its application over several years at the outlet of three catchments drained by separate storm sewers. A stochastic methodology using Monte Carlo simulations is proposed for assessing annual pollutant load, as well as the associated uncertainties, from a few event sampling campaigns and/or continuous turbidity measurements (representative of the total suspended solids concentration (TSS)). Indeed, in the latter case, the proposed method takes into account the correlation between pollutants and TSS...
October 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29020317/the-cost-effectiveness-of-one-time-hepatitis-c-screening-strategies-among-adolescents-and-young-adults-in-primary-care-settings
#7
Sabrina A Assoumou, Abriana Tasillo, Jared A Leff, Bruce R Schackman, Mari-Lynn Drainoni, C Robert Horsburgh, M Anita Barry, Craig Regis, Arthur Y Kim, Alison Marshall, Sheel Saxena, Peter C Smith, Benjamin P Linas
Background: High hepatitis C virus (HCV) rates have been reported in young people who inject drugs (PWID). We evaluated the clinical benefit and cost-effectiveness of testing among youth seen in communities with a high overall number of reported HCV cases. Methods: We developed a decision analytic model to project quality-adjusted life years (QALYs), lifetime costs (2016 US $), and incremental cost-effectiveness ratios (ICER) associated with nine strategies for one-time testing among 15 to 30-year-olds seen at urban community health centers...
September 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019495/a-novel-visible-light-responsive-nanosystem-for-cancer-treatment
#8
M Martínez-Carmona, D Lozano, A Baeza, M Colilla, M Vallet-Regí
A novel singlet-oxygen sensitive drug delivery nanocarrier able to release its cargo after exposure to visible (Vis) light from a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyrin-caps grafted via reactive oxygen species (ROS)-cleavable linkages. In the presence of Vis light porphyrin-nanocaps produce singlet oxygen molecules that break the sensitive-linker, which triggers pore uncapping and therefore allows the release of the entrapped cargo (topotecan, TOP)...
October 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28994713/the-luteovirus-p4-movement-protein-is-a-suppressor-of-systemic-rna-silencing
#9
Adriana F Fusaro, Deborah A Barton, Kenlee Nakasugi, Craig Jackson, Melanie L Kalischuk, Lawrence M Kawchuk, Maite F S Vaslin, Regis L Correa, Peter M Waterhouse
The plant viral family Luteoviridae is divided into three genera: Luteovirus, Polerovirus and Enamovirus. Without assistance from another virus, members of the family are confined to the cells of the host plant's vascular system. The first open reading frame (ORF) of poleroviruses and enamoviruses encodes P0 proteins which act as silencing suppressor proteins (VSRs) against the plant's viral defense-mediating RNA silencing machinery. Luteoviruses, such as barley yellow dwarf virus-PAV (BYDV-PAV), however, have no P0 to carry out the VSR role, so we investigated whether other proteins or RNAs encoded by BYDV-PAV confer protection against the plant's silencing machinery...
October 10, 2017: Viruses
https://www.readbyqxmd.com/read/28988390/topographic-distribution-of-brain-iron-deposition-and-small-cerebrovascular-lesions-in-amyotrophic-lateral-sclerosis-and-in-frontotemporal-lobar-degeneration-a-post-mortem-7-0-tesla-magnetic-resonance-imaging-study-with-neuropathological-correlates
#10
Jacques De Reuck, David Devos, Caroline Moreau, Florent Auger, Nicolas Durieux, Vincent Deramecourt, Florence Pasquier, Claude-Alain Maurage, Charlotte Cordonnier, Didier Leys, Regis Bordet
Amyotrophic lateral sclerosis (ALS) is associated with frontotemporal lobar degeneration (FTLD) in 15% of the cases. A neuropathological continuity between ALS and FTLD-TDP is suspected. The present post-mortem 7.0-tesla magnetic resonance imaging (MRI) study compares the topographic distribution of iron (Fe) deposition and the incidence of small cerebrovascular lesions in ALS and in FTLD brains. Seventy-eight post-mortem brains underwent 7.0-tesla MRI. The patients consisted of 12 with ALS, 38 with FTLD, and 28 controls...
October 7, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28985239/safety-and-immunogenicity-of-rvsv%C3%AE-g-zebov-gp-ebola-vaccine-in-adults-and-children-in-lambar%C3%A3-n%C3%A3-gabon-a-phase-i-randomised-trial
#11
Selidji T Agnandji, José F Fernandes, Emmanuel B Bache, Régis M Obiang Mba, Jessica S Brosnahan, Lumeka Kabwende, Paul Pitzinger, Pieter Staarink, Marguerite Massinga-Loembe, Verena Krähling, Nadine Biedenkopf, Sarah Katharina Fehling, Thomas Strecker, David J Clark, Henry M Staines, Jay W Hooper, Peter Silvera, Vasee Moorthy, Marie-Paule Kieny, Akim A Adegnika, Martin P Grobusch, Stephan Becker, Michael Ramharter, Benjamin Mordmüller, Bertrand Lell, Sanjeev Krishna, Peter G Kremsner
BACKGROUND: The rVSVΔG-ZEBOV-GP vaccine prevented Ebola virus disease when used at 2 × 107 plaque-forming units (PFU) in a trial in Guinea. This study provides further safety and immunogenicity data. METHODS AND FINDINGS: A randomised, open-label phase I trial in Lambaréné, Gabon, studied 5 single intramuscular vaccine doses of 3 × 103, 3 × 104, 3 × 105, 3 × 106, or 2 × 107 PFU in 115 adults and a dose of 2 × 107 PFU in 20 adolescents and 20 children. The primary objective was safety and tolerability 28 days post-injection...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28982151/gmdptoolbox-a-matlab-library-for-designing-spatial-management-policies-application-to-the-long-term-collective-management-of-an-airborne-disease
#12
Marie-Josée Cros, Jean-Noël Aubertot, Nathalie Peyrard, Régis Sabbadin
Designing management policies in ecology and agroecology is complex. Several components must be managed together while they strongly interact spatially. Decision choices must be made under uncertainty on the results of the actions and on the system dynamics. Furthermore, the objectives pursued when managing ecological systems or agroecosystems are usually long term objectives, such as biodiversity conservation or sustainable crop production. The framework of Graph-Based Markov Decision Processes (GMDP) is well adapted to the qualitative modeling of such problems of sequential decision under uncertainty...
2017: PloS One
https://www.readbyqxmd.com/read/28982005/3d-porous-fe-n-c-spherical-nanostructures-as-high-performance-electrocatalysts-for-oxygen-reduction-in-both-alkaline-and-acidic-media
#13
Qiliang Wei, Gaixia Zhang, Xiaohua Yang, Régis Chenitz, Dustin William H Banham, Lijun Yang, Siyu Ye, Shanna Knights, Shuhui Sun
Exploring inexpensive and high performance non-precious metal catalysts (NPMCs), to replace the rare and expensive Pt-based catalyst, for oxygen reduction reaction (ORR) is crucial for future low temperature fuel cell devices. Herein, we developed a new type of highly efficient 3D porous Fe/N/C electrocatalyst through a simple pyrolysis approach. Our systematic study revealed that the pyrolysis temperature, the surface area, and the Fe content in the catalysts largely affect the ORR performance of the Fe/N/C catalysts, and the optimized parameters have been identified...
October 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28981375/prevalence-of-salmonella-in-11-spices-offered-for-sale-from-retail-establishments-and-in-imported-shipments-offered-for-entry-to-the-united-states
#14
Guodong Zhang, Lijun Hu, Régis Pouillot, Aparna Tatavarthy, Jane M Van Doren, Daria Kleinmeier, George C Ziobro, David Melka, Hua Wang, Eric W Brown, Errol Strain, Vincent K Bunning, Steven M Musser, Thomas S Hammack
The U.S. Food and Drug Administration conducted a survey to evaluate Salmonella prevalence and aerobic plate counts in packaged (dried) spices offered for sale at retail establishments in the United States. The study included 7,250 retail samples of 11 spice types that were collected during November 2013 to September 2014 and October 2014 to March 2015. No Salmonella-positive samples (based on analysis of 125 g) were found among retail samples of cumin seed (whole or ground), sesame seed (whole, not roasted or toasted, and not black), and white pepper (ground or cracked), for prevalence estimates of 0...
October 4, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28980715/the-early-impact-of-human-papillomavirus-vaccination-on-anogenital-warts-in-qu%C3%A3-bec-canada
#15
Marc Steben, Najwa Ouhoummane, Caroline Rodier, Liliya Sinyavskaya, Paul Brassard
BACKGROUND: In Québec, Canada, a public school-based and catch-up HPV vaccination programs with the quadrivalent vaccine have been introduced in September 2008 for girls aged 9-17 years. We assessed the early impact of the HPV vaccination program on the incidence of anogenital warts (AGW) in the Quebec general population. METHODS: We used the provincial health administrative data of the Régie de l'assurance maladie du Québec (RAMQ). AGW were identified either through a prescription of podofilox, or a medical procedure code specific to AGW, or a diagnostic code for viral warts followed by a prescription of imiquimod or fluorouracil...
October 5, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28977070/cardiovascular-risk-and-bipolar-disorder-factors-associated-with-a-positive-coronary-calcium-score-in-patients-with-bipolar-disorder-type-1
#16
Aline R Wageck, Felipe S Torres, Clarissa S Gama, Dayane S Martins, Ellen Scotton, Ramiro Reckziegel, Monise Costanzi, Regis G Rosa, Flávio Kapczinski, Maurício Kunz
OBJECTIVE: Cardiovascular disease is the leading cause of death in patients with bipolar disorder. The aim of this study was to evaluate the factors associated with positive coronary calcium score (CCS) in individuals with bipolar disorder type 1. METHODS: Patients from the Bipolar Disorder Program at Hospital de Clínicas de Porto Alegre, Brazil, underwent computed tomography scanning for calcium score measurement. Clinical and sociodemographic variables were compared between patients according to their CCS status: negative (CCS = 0) or positive (CCS > 0)...
October 2, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28973682/an-open-label-analgesic-efficacy-and-safety-of-pituitary-radiosurgery-for-patients-with-opioid-refractory-pain-study-protocol-for-a-randomized-controlled-trial
#17
Pierre-Yves Borius, Stéphanie Ranque Garnier, Karine Baumstarck, Frédéric Castinetti, Anne Donnet, Eric Guedj, Philippe Cornu, Serge Blond, Sébastien Salas, Jean Régis
BACKGROUND: Hypophysectomy performed by craniotomy or percutaneous techniques leads to complete pain relief in more than 70% to 80% of cases for opioid refractory cancer pain. Radiosurgery could be an interesting alternative approach to reduce complications. OBJECTIVE: To assess the analgesic efficacy compared with standard of care is the primary goal. The secondary objectives are to assess ophthalmic and endocrine tolerance, drug consumption, quality of life, and mechanisms of analgesic action...
August 2, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28973097/association-between-fungal-contamination-and-eye-bank-prepared-endothelial-keratoplasty-tissue-temperature-dependent-risk-factors-and-antifungal-supplementation-of-optisol-gentamicin-and-streptomycin
#18
Kimberly M Brothers, Robert M Q Shanks, Susan Hurlbert, Regis P Kowalski, Elmer Y Tu
Importance: Fungal contamination and infection from donor tissues processed for endothelial keratoplasty is a growing concern, prompting analysis of donor tissues after processing. Objective: To determine whether eyebank-processed endothelial keratoplasty tissue is at higher risk of contamination than unprocessed tissue and to model eyebank processing with regard to room temperature exposure on Candida growth in optisol-gentamicin and streptomycin (GS) with and without antifungal supplementation...
September 28, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28969582/gamma-decanolactone-improves-biochemical-parameters-associated-with-pilocarpine-induced-seizures-in-male-mice
#19
Pricila Pflüger, Gabriela Gregory Regner, Vanessa R Coelho, Lucas Lima da Silva, Leopoldo Nascimento, Cassiana Macagnan Viau, Régis Adriel Zanette, Cleonice Hoffmann, Jaqueline Nascimento Picada, Jenifer Saffi, Patrícia Pereira
Gamma-decanolactone (GD) is a monoterpene effective against seizures induced by pentylenetetrazole. The mechanism of action of GD is likely to be via glutamate antagonism. GD also inhibits intracellular reactive oxygen species (ROS) generation and the lipopolysaccharide-induced expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in vitro. Considering the neuropharmacological profile of GD studied so far, we investigated the effect of intraperitoneal administration of GD 100 and 300 mg/kg on pilocarpine (PIL)-induced status epilepticus (SE) in mice...
October 2, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28961640/fractional-resurfacing-and-topical-bimatoprost-for-the-treatment-of-laser-induced-postinflammatory-hypopigmentation-on-the-lower-extremities
#20
Ashley Regis, Jennifer MacGregor, Anne Chapas
No abstract text is available yet for this article.
September 28, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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