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https://www.readbyqxmd.com/read/27922741/how-do-dual-long-acting-bronchodilators-prevent-exacerbations-of-chronic-obstructive-pulmonary-disease
#1
Kai M Beeh, Pierre-Regis Burgel, Frits M E Franssen, Jose Luis Lopez-Campos, Stelios Loukides, John R Hurst, Matjaž Fležar, Charlotte Suppli Ulrik, Fabiano Di Marco, Daiana Stolz, Arschang Valipour, Brian Casserly, Björn Ställberg, Konstantinos Kostikas, Jadwiga A Wedzicha
Decreasing the frequency and severity of exacerbations is one of the main goals of treatment for patients with chronic obstructive pulmonary disease (COPD). Several studies have documented that long-acting bronchodilators (LABDs) can reduce exacerbation rate and/or severity, and others have shown that combinations of long-acting 2-adrenergic agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) provide greater reductions in exacerbation frequency than either their monocomponents or LABA/inhaled corticosteroids (LABA/ICS) combinations in patients at low and high risk for these events...
December 6, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27921363/morphomechanics-and-developmental-constraints-in-the-evolution-of-ammonites-shell-form
#2
Alexander Erlich, Derek E Moulton, Alain Goriely, Regis Chirat
The idea that physical processes involved in biological development underlie morphogenetic rules and channel morphological evolution has been central to the rise of evolutionary developmental biology. Here, we explore this idea in the context of seashell morphogenesis. We show that a morphomechanical model predicts the effects of variations in shell shape on the ornamental pattern in ammonites, a now extinct group of cephalopods with external chambered shell. Our model shows that several seemingly unrelated characteristics of synchronous, ontogenetic, intraspecific, and evolutionary variations in ornamental patterns among various ammonite species may all be understood from the fact that the mechanical forces underlying the oscillatory behavior of the shell secreting system scale with the cross-sectional curvature of the shell aperture...
December 6, 2016: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/27921336/magnetic-anisotropy-in-pentacoordinate-ni-ii-and-co-ii-complexes-unraveling-electronic-and-geometrical-contributions
#3
Talal Mallah, Benjamin Cahier, Mauro Perfetti, Georges Zakhia, Daoud Naoufal, Fatima El-Khatib, Régis Guillot, Eric Rivière, Roberta Sessoli, Anne-Laure Barra, Nathalie Guihéry
The magnetic properties of the pentacoordinated [MII(Me4cyclam)N3]+ (Me4cyclam = tetramethylcyclam; N3 = azido and M = Ni and Co) complexes were investigated. Magnetization and EPR studies indicate that they possess an easy plane of magnetization with the axial anisotropy parameters D being close to 22 and larger than 30 cm-1 for the Ni and Co derivative, respectively. Ab initio calculations reproduce the experimental values of the zero field splitting parameters and allow determining the orientation of the anisotropy tensor axes with respect to the molecular frame...
December 6, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27916346/cardiopulmonary-exercise-testing-is-a-better-outcome-predictor-than-exercise-echocardiography-in-asymptomatic-aortic-stenosis
#4
Olivia Domanski, Marjorie Richardson, Augustin Coisne, Anne-Sophie Polge, Stephanie Mouton, François Godart, Jean Louis Edmé, Regis Matran, Patrizio Lancellotti, David Montaigne
BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship between peak VO2 and AS severity criteria derived from rest and supine exercise echocardiography (SEE) has never been explored. OBJECTIVES: We aimed to determine whether low peak VO2 (<85% of predicted value) is associated with severity parameters in SEE, and poor clinical outcome...
November 3, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27913467/transplantation-for-bone-marrow-failure-current-issues
#5
Régis Peffault de Latour
The preferred treatment of idiopathic aplastic anemia (AA) is allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen (HLA)-identical sibling donor. Transplantation from a well-matched unrelated donor (MUD) may be considered for patients without a sibling donor after failure of immunosuppressive therapy, as may alternative transplantation (mismatched, cord blood or haplo-identical HSCT) for patients without a MUD. HSCT may also be contemplated for congenital disorders in cases of pancytopenia or severe isolated cytopenia...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27909444/smallholder-farms-and-the-potential-for-sustainable-intensification
#6
Leah M Mungai, Sieglinde Snapp, Joseph P Messina, Regis Chikowo, Alex Smith, Erin Anders, Robert B Richardson, Guiying Li
The sustainable intensification of African agriculture is gaining momentum with the compelling need to increase food and agricultural production. In Southern Africa, smallholder farming systems are predominately maize-based and subject to erratic climatic conditions. Farmer crop and soil management decisions are influenced by a plethora of complex factors such as market access resource availability, social relations, environment, and various messages on sustainable farming practices. Such factors pose barriers to increasing sustainable intensification in Africa...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27908476/-analysing-heart-rate-variability-to-improve-the-monitoring-of-pain
#7
REVIEW
Laura Butruille, Julien De Jonckheere, Mathieu Jeanne, Benoît Tavernier, Régis Logier
An innovative technique based on the analysis of instantaneous heart rate variability helps to improve the prevention and management of pain and discomfort. Simple to implement, this non-invasive technique is based on the continuous recording of the electrocardiograph signal.
December 2016: Revue de L'infirmière
https://www.readbyqxmd.com/read/27905833/non-conventional-expression-systems-for-the-production-of-vaccine-proteins-and-immunotherapeutic-molecules
#8
Isabelle Legastelois, Sophie Buffin, Isabelle Peubez, Charlotte Mignon, Régis Sodoyer, Bettina Werle
The increasing demand for recombinant vaccine antigens or immunotherapeutic molecules calls into question the universality of current protein expression systems. Vaccine production can require relatively low amounts of expressed materials, but represents an extremely diverse category consisting of different target antigens with marked structural differences. In contrast, monoclonal antibodies, by definition share key molecular characteristics and require a production system capable of very large outputs, which drives the quest for highly efficient and cost-effective systems...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27902274/pleomorphochaeta-caudata-gen-nov-sp-nov-an-anaerobic-bacterium-isolated-from-an-offshore-oil-well-reclassification-of-sphaerochaeta-multiformis-mo-spc2t-as-pleomorphochaeta-multiformis-mo-spc2t-comb-nov-as-the-type-strain-of-this-new-genus-and-emended-description
#9
Boussad Arroua, Anthony Ranchou-Peyruse, Magali Ranchou-Peyruse, Michel Magot, Laurent Urios, Regis Grimaud
A strictly anaerobic Gram-negative bacterium, designated strain SEBR 4223T, was isolated from the production water of an offshore Congolese oil field. Cells were non-motile, pleomorphic and having spherical, annular or budding shapes and often exhibiting long stalks. Strain SEBR 4223T grew on a range of carbohydrates, optimally at 37°C and pH 7, in a medium containing 40 g.l-1 NaCl. Predominant fatty acids were C14:0, C14:0 DMA, C16:0 and C16:1ω7c and the major polar lipids were phosphoglycolipids (PGL), phospholipids (PL), glycolipids (GL) and diphosphatidylglycerol (DPG)...
November 14, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27891531/origanum-majorana-essential-oil-lacks-mutagenic-activity-in-the-salmonella-microsome-and-micronucleus-assays
#10
Andrea Dos Santos Dantas, Luiz Carlos Klein-Júnior, Miriana S Machado, Temenouga N Guecheva, Luciana D Dos Santos, Régis A Zanette, Fernanda B de Mello, João Antonio Pêgas Henriques, João Roberto Braga de Mello
The present study aimed to investigate the in vitro mutagenic activity of Origanum majorana essential oil. The most abundant compounds identified by GC-MS were γ-terpinene (25.73%), α-terpinene (17.35%), terpinen-4-ol (17.24%), and sabinene (10.8%). Mutagenicity was evaluated by the Salmonella/microsome test using the preincubation procedure on TA98, TA97a, TA100, TA102, and TA1535 Salmonella typhimurium strains, in the absence or in the presence of metabolic activation. Cytotoxicity was detected at concentrations higher than 0...
2016: TheScientificWorldJournal
https://www.readbyqxmd.com/read/27889197/complication-related-removal-of-totally-implantable-venous-access-port-systems-does-the-interval-between-placement-and-first-use-and-the-neutropenia-inducing-potential-of-chemotherapy-regimens-influence-their-incidence-a-four-year-prospective-study-of-4045
#11
A Kakkos, L Bresson, D Hudry, S Cousin, C Lervat, E Bogart, J P Meurant, S El Bedoui, G Decanter, K Hannebicque, C Regis, A Hamdani, N Penel, E Tresch-Bruneel, F Narducci
BACKGROUND: Totally implantable venous access port systems are widely used in oncology, with frequent complications that sometimes necessitate device removal. The aim of this study is to investigate the impact of the time interval between port placement and initiation of chemotherapy and the neutropenia-inducing potential of the chemotherapy administered upon complication-related port removal. PATIENTS AND METHODS: Between January 2010 and December 2013, 4045 consecutive patients were included in this observational, single-center prospective study...
November 5, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27885955/editorial-vestibular-schwannoma-radiosurgery-progression-or-pseudoprogression
#12
Jean Régis, Christine Delsanti, Pierre-Hugues Roche
No abstract text is available yet for this article.
November 25, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27885426/prospective-cohort-study-assessing-chronic-pain-in-patients-following-minor-surgery-for-breast-cancer
#13
Régis Fuzier, Floriane Puel, Philippe Izard, Agnès Sommet, Sébastien Pierre
PURPOSE: Pain after tumorectomy and sentinel lymph node dissection is poorly reported in the literature. We carried out a prospective survey aimed at assessing pain three months after such minor surgery for breast cancer. METHODS: The study was approved by the local ethics committee. Most surgeries followed a standard protocol involving general anesthesia with no regional analgesia technique, laryngeal mask, sufentanil and propofol for induction, and multimodal analgesia during the postoperative period...
November 24, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27885030/social-status-alters-immune-regulation-and-response-to-infection-in-macaques
#14
Noah Snyder-Mackler, Joaquín Sanz, Jordan N Kohn, Jessica F Brinkworth, Shauna Morrow, Amanda O Shaver, Jean-Christophe Grenier, Roger Pique-Regi, Zachary P Johnson, Mark E Wilson, Luis B Barreiro, Jenny Tung
Social status is one of the strongest predictors of human disease risk and mortality, and it also influences Darwinian fitness in social mammals more generally. To understand the biological basis of these effects, we combined genomics with a social status manipulation in female rhesus macaques to investigate how status alters immune function. We demonstrate causal but largely plastic social status effects on immune cell proportions, cell type-specific gene expression levels, and the gene expression response to immune challenge...
November 25, 2016: Science
https://www.readbyqxmd.com/read/27880006/impairing-both-hma4-homeologs-is-required-for-cadmium-reduction-in-tobacco
#15
Verena Liedschulte, Hélène Laparra, James Nicolas Duncan Battey, Joanne Deborah Schwaar, Hervé Broye, Régis Mark, Markus Klein, Simon Goepfert, Lucien Bovet
In tobacco, the heavy metal P1B-ATPases HMA4.1 and HMA4.2 function in root-to-shoot zinc and cadmium transport. We present greenhouse and field data that dissect the possibilities to impact the two homeologous genes in order to define the best strategy for leaf cadmium reduction. In a first step, both genes were silenced using an RNAi approach leading to >90% reduction of leaf cadmium content. To modulate HMA4 function more precisely, mutant HMA4.1 and HMA4.2 alleles of a TILLING population were combined...
November 23, 2016: Plant, Cell & Environment
https://www.readbyqxmd.com/read/27876627/il-33-fine-tunes-mast-cell-degranulation-and-chemokine-production-at-the-single-cell-level
#16
Régis Joulia, Fatima-Ezzahra L'Faqihi, Salvatore Valitutti, Eric Espinosa
BACKGROUND: Mast cells are versatile key components of allergy and inflammation, known to respond to both innate and adaptive immunological stimuli. However the response of individual mast cells to cumulative stimuli remains poorly understood. OBJECTIVES: To dissect mast cell responses at the single-cell level and their potentiation by IL-33. METHODS: We monitored mast cell degranulation in real time by exploiting the capacity of fluorochrome-labeled avidin to stain degranulating cells...
November 19, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27870979/coronary-disease-risk-assessment-in-men-comparison-between-ascvd-risk-versus-framingham
#17
Natália Maria Maciel Guerra-Silva, Fernanda Sene Santucci, Ricardo Castanho Moreira, Cristiano Massao Tashima, Simone Cristina Castanho Sabaini de Melo, Leonardo Regis Leira Pereira, Debora de Mello Gonçales Sant'Ana
INTRODUCTION: This study evaluated the risk of men developing coronary heart disease and its determinant variables, comparing these results through two validated coronary risk scales. METHODS: A cross sectional epidemiological analytical study in which data were collected by spontaneous demand, through a semi-structured questionnaire, clinical examination, and blood collection. The Chi-square test, logistic regression and Kappa for statistical analysis were performed...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27870595/human-energy-expenditure-and-postural-coordination-on-the-mechanical-horse
#18
Héloïse Baillet, Régis Thouvarecq, Eric Vérin, Claire Tourny, Nicolas Benguigui, John Komar, David Leroy
The authors investigated and compared the energy expenditure and postural coordination of two groups of healthy subjects on a mechanical horse at 4 increasing oscillation frequencies. Energy expenditure was assessed from the oxygen consumption, respiratory quotient, and heart rate values, and postural coordination was characterized by relative phase computations between subjects (elbow, head, trunk) and horse. The results showed that the postural coordination of the riders was better adapted (i.e., maintenance of in-phase and antiphase) than that of the nonriders, but the energy expenditure remains the same...
November 21, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/27869595/infectious-dose-of-listeria-monocytogenes-in-outbreak-linked-to-ice-cream-united-states-2015
#19
Régis Pouillot, Karl C Klontz, Yi Chen, Laurel S Burall, Dumitru Macarisin, Matthew Doyle, Kären M Bally, Errol Strain, Atin R Datta, Thomas S Hammack, Jane M Van Doren
The relationship between the number of ingested Listeria monocytogenes cells in food and the likelihood of developing listeriosis is not well understood. Data from an outbreak of listeriosis linked to milkshakes made from ice cream produced in 1 factory showed that contaminated products were distributed widely to the public without any reported cases, except for 4 cases of severe illness in persons who were highly susceptible. The ingestion of high doses of L. monocytogenes by these patients infected through milkshakes was unlikely if possible additional contamination associated with the preparation of the milkshake is ruled out...
December 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27865758/bone-morphogenetic-protein-2-and-transforming-growth-factor-%C3%AE-1-inhibit-the-expression-of-the-proinflammatory-cytokine-il-34-in-rheumatoid-arthritis-synovial-fibroblasts
#20
Marguerite Chemel, Regis Brion, Aude-Isabelle Segaliny, Audrey Lamora, Celine Charrier, Benedicte Brulin, Yves Maugars, Benoit Le Goff, Dominique Heymann, Franck Verrecchia
IL-34 is a proinflammatory cytokine implicated in rheumatoid arthritis (RA). The current study aimed to assess the IL-34 expression in response to two members of the transforming growth factor (TGF)-β family, TGF-β1 and bone morphogenetic protein (BMP)-2, in synovial fibroblasts from RA patients. IL-34, TGF-β1, and BMP-2 productions were measured in patient synovial fluids by enzyme-linked immunosorbent assay. IL-34 mRNA levels were quantified by real-time quantitative PCR in human synovial fibroblasts and murine mesenchymal stem cells...
November 17, 2016: American Journal of Pathology
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