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https://www.readbyqxmd.com/read/28433691/direct-monitoring-of-basophil-degranulation-by-using-avidin-based-probes
#1
Régis Joulia, Claire Mailhol, Salvatore Valitutti, Alain Didier, Eric Espinosa
We show that fluorescent avidin binds to basophil cell surface upon degranulation and can be used to set up a new basophil activation test (BAT). This new assay provides results comparable to those provided by the CD63 exposure-based BAT, but has the advantage to directly monitor granule exteriorization.
April 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28432613/pediatric-tonsillectomy-is-a-resource-intensive-procedure-a-study-of-canadian-health-administrative-data
#2
Kimmo T T Murto, Sherri L Katz, Daniel I McIsaac, Matthew A Bromwich, Régis Vaillancourt, Carl van Walraven
BACKGROUND: The majority of pediatric surgeries are performed in a day surgery setting. The rate of adverse postoperative outcomes and the factors that influence them are poorly described in the Canadian setting. Concerns about the safety of adenotonsillectomy (AT) have been raised. The objective of this Ontario-based study was to determine the rates and risks of hospital readmission, emergency department (ED) visits, or deaths within 30 days following common pediatric surgeries, with an emphasis on AT...
April 21, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28430290/frequency-and-topography-of-small-cerebrovascular-lesions-in-vascular-and-in-mixed-dementia-a-post-mortem-7-tesla-magnetic-resonance-imaging-study-with-neuropathological-correlates
#3
Jacques De Reuck, Florent Auger, Nicolas Durieux, Vincent Deramecourt, Claude-Alain Maurage, Charlotte Cordonnier, Florence Pasquier, Didier Leys, Regis Bordet
<i><b>Introduction</b>: Mixed dementia (MixD) refers to a combination of definite Alzheimer's disease (AD) and vascular encephalopathy. The existence of a "pure" type of vascular dementia (VaD) is controversial. There is a need to find magnetic resonance imaging (MRI) characteristics allowing the distinction between VaD and MixD. The present post-mortem 7.0-tesla MRI compares the frequency or severity and the topography of the small cerebrovascular lesions in brains of patients with VaD and with MixD...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28415799/the-pancreas-responds-to-remote-damage-and-systemic-stress-by-secretion-of-the-pancreatic-secretory-proteins-psp-regi-and-pap-regiii
#4
Theresia Reding, Cristian Palmiere, Clinsyjos Pazhepurackel, Marc Schiesser, Daniel Bimmler, Andrea Schlegel, Ursula Süss, Sabrina Steiner, Leandro Mancina, Gitta Seleznik, Rolf Graf
INTRODUCTION: In patients with infection and sepsis serum levels of Pancreatic Stone protein/regenerating protein I (PSP) are highly elevated. The origin of PSP during these conditions is presumably the pancreas, however, an intestinal origin cannot be excluded. Similarly, pancreatitis-associated protein (PAP) was identified in the pancreas. These proteins were also localized in intestinal organs. Here we aim to elucidate the bio-distribution of PSP and PAP in animal models of sepsis and in healthy humans...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414256/salmonella-survival-kinetics-on-pecans-hazelnuts-and-pine-nuts-at-various-water-activities-and-temperatures
#5
Sofia M Santillana Farakos, Régis Pouillot, Susanne E Keller
The impact of temperature, water activity (aw), and nut composition on Salmonella survival on tree nuts has not been thoroughly examined. The aim of this study was to determine the effect of temperature, aw, and nut composition on the survival of Salmonella on tree nuts and develop predictive models. Pecans, hazelnuts, and pine nuts were chosen based on differences in their typical fat content. Nuts were inoculated with a cocktail of five Salmonella serotypes (11 log CFU/mL) and then were dried and stored at 4, 10, and 25°C at 0...
April 17, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28414255/a-quantitative-assessment-of-the-risk-of-human-salmonellosis-arising-from-the-consumption-of-almonds-in-the-united-states-the-impact-of-preventive-treatment-levels
#6
Sofia M Santillana Farakos, Régis Pouillot, Rhoma Johnson, Judith Spungen, Insook Son, Nathan Anderson, Jane M Van Doren
The presence of Salmonella on almonds continues to result in product-related outbreaks and recalls in the United States. In this study, the impact of microbial reduction treatment levels (1 to 5 log CFU) on the risk of human salmonellosis from the consumption of almond kernels in the United States was evaluated. An exposure model, including major steps in almond processing, was used to estimate prevalence and levels of contamination of Salmonella on almonds at the point of consumption. A Salmonella dose-response model and consumption data for almonds in the United States were used to assess risk of illness per serving and per year, quantifying variability and uncertainty separately...
April 17, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28413012/-identifying-frailty-and-the-importance-of-personalised-support
#7
Mathilde Nicolas, Régis Gonthier, Émilie Crawford-Achour
Over recent years, many hospitals have been looking to promote optimum ageing by developing a strategy for identifying frailty in elderly people. This raises the question of prevention in the field of ageing and the capacities to change behaviour which is harmful to health at any age. Early and long-term support is essential.
March 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28412552/copper-containing-mesoporous-bioactive-glass-nanoparticles-as-multifunctional-agent-for-bone-regeneration
#8
Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giogia Novajra, Maria Vallet-Regí, Giovanna Bruni, Almudena Torres-Pardo, José M González-Calbet, Livia Visai, Chiara Vitale-Brovarone
The application of mesoporous bioactive glasses (MBGs) containing controllable amount of different ions, with the aim to impart antibacterial activity, as well as stimulation of osteogenesis and angiogenesis, is attracting an increasing interest. In this contribution, in order to endow nano-sized MBG with additional biological functions, the framework of a binary SiO2-CaO mesoporous glass was modified with different concentrations of copper ions (2 and 5% mol.), through a one-pot ultrasound-assisted sol-gel procedure...
April 12, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28410584/case-crossover-study-to-examine-the-change-in-postpartum-risk-of-pulmonary-embolism-over-time
#9
Grégoire Ficheur, Alexandre Caron, Jean-Baptiste Beuscart, Laurie Ferret, Yu-Jin Jung, Charles Garabedian, Régis Beuscart, Emmanuel Chazard
BACKGROUND: Although the current guidelines recommend anticoagulation up until 6 weeks after delivery in women at high risk of venous thromboembolism (VTE), the risk of VTE may extend beyond 6 weeks. Our objective was to estimate the risk of a pulmonary embolism in successive 2-week intervals during the postpartum period. METHODS: In a population-based, case-crossover study, we analyzed the French national inpatient database from 2007 to 2013 (n = 5,517,680 singleton deliveries)...
April 14, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28402365/vectorization-of-ultrasound-responsive-nanoparticles-in-placental-mesenchymal-stem-cells-for-cancer-therapy
#10
Juan L Paris, Paz de la Torre, M Victoria Cabañas, Miguel Manzano, Montserrat Grau, Ana I Flores, María Vallet-Regí
A new platform constituted by engineered responsive nanoparticles transported by human mesenchymal stem cells is here presented as a proof of concept. Ultrasound-responsive mesoporous silica nanoparticles are coated with polyethylenimine to favor their effective uptake by decidua-derived mesenchymal stem cells. The responsive-release ability of the designed nanoparticles is confirmed, both in vial and in vivo. In addition, this capability is maintained inside the cells used as carriers. The migration capacity of the nanoparticle-cell platform towards mammary tumors is assessed in vitro...
April 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28401319/training-charter-in-spasticity-neurosurgery-added-competence
#11
REVIEW
D E Sakas, J K Krauss, J Regis, M Scerrati, J van Loon, M Sindou, P Mertens
No abstract text is available yet for this article.
April 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28399846/palliative-sedation-challenging-the-professional-competency-of-health-care-providers-and-staff-a-qualitative-focus-group-and-personal-written-narrative-study
#12
Danièle Leboul, Régis Aubry, Jean-Michel Peter, Victor Royer, Jean-François Richard, Frédéric Guirimand
BACKGROUND: Despite recent advances in palliative medicine, sedating a terminally ill patient is regarded as an indispensable treatment to manage unbearable suffering. With the prospect of widespread use of palliative sedation, the feelings and representations of health care providers and staff (carers) regarding sedation must be carefully explored if we are to gain a better understanding of its impact and potential pitfalls. The objective of the study was to provide a comprehensive description of the opinions of carers about the use of sedation practices in palliative care units (PCU), which have become a focus of public attention following changes in legislation...
April 11, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28398706/can-we-rely-on-pharmacy-claims-databases-to-ascertain-maternal-use-of-medications-during-pregnancy
#13
Jin-Ping Zhao, Odile Sheehy, Jessica Gorgui, Anick Bérard
BACKGROUND: Administrative databases are increasingly used to measure drug exposure in perinatal pharmacoepidemiology. We aimed to estimate the concordance between records of prescriptions filled in pharmacies and self-reported drug use during pregnancy. METHODS: Data on self-reported medication use were collected at each trimester of pregnancy among a sub-sample from the Organization of Teratology Information Specialists Antidepressants in Pregnancy Cohort. Women were eligible if they were Quebec resident and provided their pharmacist's contact information...
April 3, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28398052/mechanistic-aspects-of-the-polymerization-of-lactide-using-a-highly-efficient-aluminum-iii-catalytic-system
#14
Carine Robert, Thibault E Schmid, Vincent Richard, Pierre Haquette, Sumesh K Raman, Marie-Noelle Rager, Régis M Gauvin, Yohann Morin, Xavier Trivelli, Vincent Guérineau, Iker Del Rosal, Laurent Maron, Christophe M Thomas
We report here a unique example of an in situ generated aluminum initiator stabilized by a C2-symmetric salen ligand which shows a hitherto unknown high activity for the ROP of rac-lactide at room temperature. Using a simple and robust catalyst system, which is prepared from a salen complex and an onium salt, this convenient route employs readily available reagents that afford polylactide in good yields with narrow polydispersity indices, without the need for time-consuming and expensive processes that are typically required for catalyst preparation and purification...
April 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28398045/conformational-effects-through-hydrogen-bonding-in-a-constrained-%C3%AE-peptide-template-from-intraresidue-seven-membered-rings-to-a-gel-forming-sheet-structure
#15
Hawraà Awada, Claire M Grison, Florence Charnay-Pouget, Jean-Pierre Baltaze, François Brisset, Régis Guillot, Sylvie Robin, Ali Hachem, Nada Jaber, Daoud Naoufal, Ogaritte Yazbeck, David J Aitken
A series of three short oligomers (di-, tri-, and tetramers) of cis-2-(aminomethyl)cyclobutane carboxylic acid, a γ-amino acid featuring a cyclobutane ring constraint, were prepared, and their conformational behavior was examined spectroscopically and by molecular modeling. In dilute solutions, these peptides showed a number of low-energy conformers, including ribbonlike structures pleated around a rarely observed series of intramolecular seven-membered hydrogen bonds. In more concentrated solutions, these interactions defer to an organized supramolecular assembly, leading to thermoreversible organogel formation notably for the tripeptide, which produced fibrillar xerogels...
April 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28390017/interaction-of-tio2-nanoparticles-with-proteins-from-aquatic-organisms-the-case-of-gill-mucus-from-blue-mussel
#16
Adeline Bourgeault, Véronique Legros, Florence Gonnet, Regis Daniel, Aurélie Paquirissamy, Clémence Bénatar, Olivier Spalla, Corinne Chanéac, Jean-Philippe Renault, Serge Pin
To better understand the mechanisms of TiO2 nanoparticle (NP) uptake and toxicity in aquatic organisms, we investigated the interaction of NPs with the proteins found in gill mucus from blue mussels. Mucus is secreted by many aquatic organisms and is often their first line of defense against pathogens, xenobiotics, and other sources of environmental stress. Here, five TiO2 NPs and one SiO2 NP were incubated with gill mucus and run out on a one-dimensional polyacrylamide gel for a comparative qualitative analysis of the free proteins in the mucosal solution and the proteins bound to NPs...
April 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28379309/evidence-of-archaeal-methanogens-in-brain-abscess
#17
Michel Drancourt, Vanessa Demonfort Nkamga, Ndèye Aïssatou Lakhe, Jean-Marie Régis, Henry Dufour, Pierre-Edouard Fournier, Yassina Bechah, W Michael Scheld, Didier Raoult
Background.: Methanogens are antibiotic-resistant anaerobic archaea which escape routine detection in clinical microbiology. We hypothesized that methanogens may participate as part of the anaerobic community causing brain abscess. Methods.: Methanogens were investigated in one index sample by specific PCR-sequencing and culture. The pathogenesis of a methanogen isolate was assessed in a mouse model of brain abscess. Archaea-specific qPCR and metagenomics were used to detect specific archaeal sequences in brain abscess samples and controls...
April 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28376546/association-of-nursing-overtime-nurse-staffing-and-unit-occupancy-with-health-care-associated-infections-in-the-nicu
#18
Marc Beltempo, Régis Blais, Guy Lacroix, Michèle Cabot, Bruno Piedboeuf
Objective This study aims to assess the association of nursing overtime, nurse staffing, and unit occupancy with health care-associated infections (HCAIs) in the neonatal intensive care unit (NICU). Study Design A 2-year retrospective cohort study was conducted for 2,236 infants admitted in a Canadian tertiary care, 51-bed NICU. Daily administrative data were obtained from the database "Logibec" and combined to the patient outcomes database. Median values for the nursing overtime hours/total hours worked ratio, the available to recommended nurse staffing ratio, and the unit occupancy rate over 3-day periods before HCAI were compared with days that did not precede infections...
April 4, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28375018/design-and-magnetic-properties-of-a-mononuclear-co-ii-single-molecule-magnet-and-its-antiferromagnetically-coupled-binuclear-derivative
#19
Fatima El-Khatib, Benjamin Cahier, Feng Shao, Maurici López-Jordà, Régis Guillot, Eric Rivière, Hala Hafez, Zeinab Saad, Jean-Jacques Girerd, Nathalie Guihéry, Talal Mallah
The preparations of related mononuclear and binuclear Co(II) complexes with a quasi-identical local C3v symmetry using a cryptand organic ligand are reported. The mononuclear complex behaves as a single molecule magnet (SMM). A relatively weak antiferromagnetic exchange coupling (J) of the same order of magnitude as the local magnetic anisotropy (D) is determined experimentally and theoretically for the binuclear complex. The weak magnitude of the antiferromagnetic exchange coupling, analyzed using a combination of broken-symmetry density functional theory and wave function based calculations, is ascribed to the weak overlap between the singly occupied orbitals because of the local C3v symmetry of the Co(II) ions; the organic ligand was found to contribute to the exchange coupling as the azido bridge that directly links the Co(II) ions...
April 4, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28372793/-erratum-to-immunotherapy-and-allogeneic-stem-cells-transplantation-bull-cancer-103-2016-s164-174
#20
Flore Sicre de Fontbrune, Doriane Cavalieri, Mathieu Leclerc, Florence Beckerich, Sébastien Maury, Régis Peffault de Latour, Stéphanie N-Guyen, Jacques-Olivier Bay
No abstract text is available yet for this article.
April 1, 2017: Bulletin du Cancer
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