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JOURNAL ARTICLE
Barun Kumar Chakrabarti, Gerard Bree, Anh Dao, Guillaume Remy, Mengzheng Ouyang, Koray Bahadır Dönmez, Billy Wu, Mark Williams, Nigel P Brandon, Chandramohan George, Chee Tong John Low
Lithium-ion battery electrodes are typically manufactured via slurry casting, which involves mixing active material particles, conductive carbon, and a polymeric binder in a solvent, followed by casting and drying the coating on current collectors (Al or Cu). These electrodes are functional but still limited in terms of pore network percolation, electronic connectivity, and mechanical stability, leading to poor electron/ion conductivities and mechanical integrity upon cycling, which result in battery degradation...
April 16, 2024: ACS Applied Materials & Interfaces
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JOURNAL ARTICLE
Courtney Sakolish, Haley L Moyer, Han-Hsuan D Tsai, Lucie C Ford, Allison N Dickey, Piyush Bajaj, Remi Villenave, Philip Hewitt, Stephen S Ferguson, Jason Stanko, Ivan Rusyn
In vitro models that can faithfully replicate critical aspects of kidney tubule function such as directional drug transport are in high demand in pharmacology and toxicology. Accordingly, development and validation of new models is underway. The objective of this study was to characterize physiological and transport functions of various sources of human renal proximal tubule epithelial cells (RPTECs). We tested TERT1-immortalized RPTEC, including OAT1-, OCT2- or OAT3-overexpressing variants, and primary RPTECs...
April 16, 2024: Drug Metabolism and Disposition: the Biological Fate of Chemicals
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JOURNAL ARTICLE
Joshua Talib, Abayomi A Abatan, Remy HoekSpaans, Edmund I Yamba, Temitope S Egbebiyi, Cyril Caminade, Anne Jones, Cathryn E Birch, Oladapo M Olagbegi, Andrew P Morse
Malaria transmission across sub-Saharan Africa is sensitive to rainfall and temperature. Whilst different malaria modelling techniques and climate simulations have been used to predict malaria transmission risk, most of these studies use coarse-resolution climate models. In these models convection, atmospheric vertical motion driven by instability gradients and responsible for heavy rainfall, is parameterised. Over the past decade enhanced computational capabilities have enabled the simulation of high-resolution continental-scale climates with an explicit representation of convection...
2024: PloS One
#24
REVIEW
Romain Jouffroy, Félix Djossou, Rémi Neviere, Samir Jaber, Benoît Vivien, Nicholas Heming, Papa Gueye
This article describes the structures and processes involved in healthcare delivery for sepsis, from the prehospital setting until rehabilitation. Quality improvement initiatives in sepsis may reduce both morbidity and mortality. Positive outcomes are more likely when the following steps are optimized: early recognition, severity assessment, prehospital emergency medical system activation when available, early therapy (antimicrobials and hemodynamic optimization), early orientation to an adequate facility (emergency room, operating theater or intensive care unit), in-hospital organ failure resuscitation associated with source control, and finally a comprehensive rehabilitation program...
April 16, 2024: Annals of Intensive Care
#25
JOURNAL ARTICLE
Emmanuel Klinger, Andrei Mursa, Carlos M Rivera-Aguilar, Rémy Vicarini, Nicolas Passilly, Rodolphe Boudot
We report on the characterization of sub-Doppler resonances detected by probing the 6S1/2 - 7P1/2 transition of the Cs atom at 459 nm in a microfabricated vapor cell. The dependence of the sub-Doppler resonance (linewidth, amplitude) on some key experimental parameters, including the laser intensity and the cell temperature, is investigated. These narrow atomic resonances are of interest for high-resolution spectroscopy and instrumentation and may constitute the basis of a high-stability microcell optical standard...
April 15, 2024: Optics Letters
#26
JOURNAL ARTICLE
Brian E Lacy, Patrick Gagnon-Sanschagrin, Zeev Heimanson, Rebecca Bungay, Remi Bellefleur, Annie Guérin, Brock Bumpass, Danellys Borroto, George Joseph, Ankur A Dashputre
INTRODUCTION: Objective assessment of treatment effectiveness using real-world claims data is challenging. This study assessed treatment-free intervals (TFI) as a proxy for treatment effectiveness, and all-cause healthcare costs among adult patients with irritable bowel syndrome with diarrhea (IBS-D) treated with rifaximin or eluxadoline in the USA. METHODS: Adult patients (18-64 years) with IBS-D and ≥ 1 rifaximin or eluxadoline prescription were identified in the IQVIA PharMetrics® Plus database (10/01/2015-12/31/2021) and classified into two mutually exclusive cohorts (i...
April 15, 2024: Advances in Therapy
#27
JOURNAL ARTICLE
Aymeric Jacquemin, Thierry Naas, Laurent Dortet, Rémy A Bonnin
No abstract text is available yet for this article.
April 15, 2024: Journal of Antimicrobial Chemotherapy
#28
JOURNAL ARTICLE
Nicolas Ludwig, Catherine Galindo, Clea Witjaksono, Antoine Danvin, Philippe Peaupardin, Dominique Muller, Tamon Kusumoto, Satoshi Kodaira, Rémi Barillon, Quentin Raffy
While particle therapy has been used for decades for cancer treatment, there is still a lack of information on the molecular mechanisms of biomolecules radiolysis by accelerated ions. Here, we examine the effects of accelerated protons on highly concentrated native myoglobin, by means of Fourier transform infrared and UV-Visible spectroscopies. Upon irradiation, the secondary structure of the protein is drastically modified, from mostly alpha helices conformation to mostly beta elements at highest fluence. These changes are accompanied by significant production of carbon monoxide, which was shown to come from heme degradation under irradiation...
April 14, 2024: Scientific Reports
#29
JOURNAL ARTICLE
Gaëlle Quiniou, Leslie Andromaque, Rémi Duclaux-Loras, Océane Dinet, Ornella Cervantes, Mallorie Verdet, Camille Meunier, Gilles Boschetti, Christophe Viret, Stéphane Nancey, Mathias Faure, Aurore Rozières
Crohn disease (CD) is an inflammatory bowel disease whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD is associated with single-nucleotide polymorphisms affecting several genes involved in macroautophagy/autophagy, the catabolic process that ensures the degradation and recycling of cytosolic components and microorganisms. In a clinical translation perspective, monitoring the autophagic activity of CD patients will require some knowledge on the intrinsic functional status of autophagy...
April 14, 2024: Autophagy
#30
JOURNAL ARTICLE
James P Caruso, Remi Wilson, Luke Dosselman, John Eakin, Chandrasekhar Sundarrajan, Ammar Adenwalla, Ahmed K Almekkawi, Salah G Aoun, Carlos A Bagley, Michael Van Hal, Mazin Al Tamimi
BACKGROUND: Symptomatic cervical spondylosis is often treated with anterior cervical decompression and fusion (ACDF). However, few factors can predict which cervical level will degenerate and require intervention. This analysis evaluates pre-procedural factors associated with level of first-time single-level ACDF. METHODS: We performed a retrospective analysis of patients who underwent single-level ACDF without prior history of spine surgery. Mann Whitney U-tests and Spearman rank-order correlation were performed for analyses of associations between variables of interest and ACDF level...
April 11, 2024: World Neurosurgery
#31
JOURNAL ARTICLE
Broderick Dickerson, Jonathan Maury, Victoria Jenkins, Kay Nottingham, Dante Xing, Drew E Gonzalez, Megan Leonard, Jacob Kendra, Joungbo Ko, Choongsung Yoo, Sarah Johnson, Rémi Pradelles, Martin Purpura, Ralf Jäger, Ryan Sowinski, Christopher J Rasmussen, Richard B Kreider
BACKGROUND: Microalgae like Phaeodactylum tricornutum (PT) contain the carotenoid, fucoxanthin, which has been purported to promote fat loss, lower blood lipids, and improve glucose management. This study examined whether dietary supplementation with microalgae extracts from PT containing 4.4 mg/d of fucoxanthin affects changes in body composition or health markers in overweight women during an exercise and diet intervention. MATERIALS AND METHODS: A total of 37 females (28...
March 28, 2024: Nutrients
#32
JOURNAL ARTICLE
Marylin Madamet, Isabelle Fonta, Joel Mosnier, Nicolas Benoit, Rémy Amalvict, Sébastien Briolant, French National Reference Centre For Imported Malaria Study Group, Bruno Pradines
The early diagnosis of malaria is crucial to controlling morbidity and mortality. The World Health Organization (WHO) recommends diagnosing malaria either using light microscopy or a malaria rapid diagnostic test (RDT). Most RDTs use antibodies to detect two P. falciparum histidine-rich proteins named PfHRP2 and PfHRP3. However, false-negative results are known to occur due to the poor performance of RDTs depending on the species and the deletion of the Pfhrp2 and Pfhrp3 genes. This study evaluated new malaria RDTs for the detection of the human Plasmodium species...
March 29, 2024: Diagnostics
#33
JOURNAL ARTICLE
Georges E Janssens, Marte Molenaars, Katharina Herzog, Lotte Grevendonk, Carlijn M E Remie, Martin A T Vervaart, Hyung L Elfrink, Eric J M Wever, Bauke V Schomakers, Simone W Denis, Hans R Waterham, Mia L Pras-Raves, Michel van Weeghel, Antoine H C van Kampen, Alessandra Tammaro, Loes M Butter, Sanne van der Rijt, Sandrine Florquin, Aldo Jongejan, Perry D Moerland, Joris Hoeks, Patrick Schrauwen, Frédéric M Vaz, Riekelt H Houtkooper
Studies in preclinical models suggest that complex lipids, such as phospholipids, play a role in the regulation of longevity. However, identification of universally conserved complex lipid changes that occur during aging, and how these respond to interventions, is lacking. Here, to comprehensively map how complex lipids change during aging, we profiled ten tissues in young versus aged mice using a lipidomics platform. Strikingly, from >1,200 unique lipids, we found a tissue-wide accumulation of bis(monoacylglycero)phosphate (BMP) during mouse aging...
April 12, 2024: Nature aging
#34
JOURNAL ARTICLE
Rémi Philippe, Rémi Janet, Koosha Khalvati, Rajesh P N Rao, Daeyeol Lee, Jean-Claude Dreher
Humans frequently interact with agents whose intentions can fluctuate between competition and cooperation over time. It is unclear how the brain adapts to fluctuating intentions of others when the nature of the interactions (to cooperate or compete) is not explicitly and truthfully signaled. Here, we use model-based fMRI and a task in which participants thought they were playing with another player. In fact, they played with an algorithm that alternated without signaling between cooperative and competitive strategies...
April 12, 2024: Nature Communications
#35
JOURNAL ARTICLE
Oliver Barnstedt, Petra Mocellin, Stefan Remy
The dorsal hippocampus (dHPC) is a key brain region for the expression of spatial memories, such as navigating towards a learned reward location. The nucleus accumbens (NAc) is a prominent projection target of dHPC and implicated in value-based action selection. Yet, the contents of the dHPC→NAc information stream and their acute role in behavior remain largely unknown. Here, we found that optogenetic stimulation of the dHPC→NAc pathway while mice navigated towards a learned reward location was both necessary and sufficient for spatial memory-related appetitive behaviors...
April 12, 2024: Nature Communications
#36
JOURNAL ARTICLE
Remy S Petersen, Lauré M Fijen, Christian Apfelbacher, Markus Magerl, Karsten Weller, Werner Aberer, Adil Adatia, Paul Audhya, Noémi-Anna Bara, Stephen Betschel, Isabelle Boccon-Gibod, Laurence Bouillet, Nicholas Brodszki, Paula J Busse, Thomas Buttgereit, Anette Bygum, Mauro Cancian, Timothy Craig, Dorottya Csuka, Henriette Farkas, Daria Fomina, Johana Gil-Serrano, Mark Gompels, Guillermo Guidos Fogelbach, Mar Guilarte, Michihiro Hide, Sorena Kiani-Alikhan, Tamar Kinaciyan, Annet Lenten, Ramon Lleonart, Hilary Longhurst, William R Lumry, Alejandro Malbran, Laura Malinauskiene, Juan J Matta Campos, Joan Mendivil, Sandra A Nieto-Martinez, Jonathan G Peter, Grzegorz Porebski, Avner Reshef, Marc Riedl, Anna Valerieva, Susan Waserman, Marcus Maurer, Danny M Cohn
BACKGROUND: Clinical trials investigating drugs for acute treatment of hereditary angioedema attacks have assessed many different outcomes. This heterogeneity limits comparability of trial results and may lead to selective outcome reporting bias and a high burden on trial participants. OBJECTIVE: To achieve consensus on a Core Outcome Set comprising key outcomes that should ideally be utilized in all clinical efficacy trials involving acute treatment of hereditary angioedema attacks...
April 10, 2024: Journal of Allergy and Clinical Immunology in Practice
#37
JOURNAL ARTICLE
Alicia Maroto, Dany Jeanne Dit Fouque, Rémy Lartia, Antony Memboeuf
Energy-resolved mass spectrometry (ERMS) and an isotopically labelled internal standard were successfully combined to accurately quantify a tryptic peptide despite the presence of an isobaric interference. For this purpose, electrospray ionisation tandem mass spectrometry (ESI-MS/MS) experiments were conducted into an ion trap instrument using an unconventional 8 m/z broadband isolation window, which encompassed both the tryptic peptide and its internal standard. Interference removal was assessed by determining an excitation voltage that was high enough to maintain a constant value for the analyte/internal standard peaks intensity ratio, thus ensuring accurate quantification even in the presence of isobaric contamination...
May 2024: Journal of Mass Spectrometry: JMS
#38
JOURNAL ARTICLE
Thomas Roder, Grégory Pimentel, Pascal Fuchsmann, Mireille Tena Stern, Ueli von Ah, Guy Vergères, Stephan Peischl, Ola Brynildsrud, Rémy Bruggmann, Cornelia Bär
Unraveling bacterial gene function drives progress in various areas, such as food production, pharmacology, and ecology. While omics technologies capture high-dimensional phenotypic data, linking them to genomic data is challenging, leaving 40-60% of bacterial genes undescribed. To address this bottleneck, we introduce Scoary2, an ultra-fast microbial genome-wide association studies (mGWAS) software. With its data exploration app and improved performance, Scoary2 is the first tool to enable the study of large phenotypic datasets using mGWAS...
April 11, 2024: Genome Biology
#39
JOURNAL ARTICLE
Pierre Recouvreux, Pritha Pai, Valentin Dunsing, Rémy Torro, Monika Ludanyi, Pauline Mélénec, Mariem Boughzala, Vincent Bertrand, Pierre-François Lenne
Different signaling mechanisms concur to ensure robust tissue patterning and cell fate instruction during animal development. Most of these mechanisms rely on signaling proteins that are produced, transported, and detected. The spatiotemporal dynamics of signaling molecules are largely unknown, yet they determine signal activity's spatial range and time frame. Here, we use the Caenorhabditis elegans embryo to study how Wnt ligands, an evolutionarily conserved family of signaling proteins, dynamically organize to establish cell polarity in a developing tissue...
April 5, 2024: Current Biology: CB
#40
JOURNAL ARTICLE
Linda S Franck, Renee Mehra, Linda Remy, Jennifer Rienks
CONTEXT: Prior to the COVID-19 pandemic, home visiting services for low-income children and families were provided almost entirely in person. Little is known about clients' experience of home visiting provided virtually by video or phone instead of, or in addition to, in-person home visiting. OBJECTIVE: To explore the views of clients in the California Work Opportunity and Responsibility to Kids (CalWORKs) Home Visiting Program (HVP) across California during the first 2 years of the pandemic...
May 2024: Journal of Public Health Management and Practice: JPHMP
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