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https://www.readbyqxmd.com/read/29236356/proteomics-in-pathology
#1
Rémi Longuespée, Rita Casadonte, Kristina Schwamborn, David Reuss, Daniel Kazdal, Katharina Kriegsmann, Andreas von Deimling, Wilko Weichert, Peter Schirmacher, Jörg Kriegsmann, Mark Kriegsmann
Proteomic approaches are of growing importance in the biologist's toolbox. It greatly benefited from past and recent advances in sampling, chemical processing, mass spectrometry (MS) instrumentation and data processing. MS-based analysis of proteins is now on the process to be translated in pathology for objective diagnoses. In this viewpoint we present the workflows that we think are the most promising for applications in pathology. We also comment what we think are prerequisites for a successful translational implementation...
December 13, 2017: Proteomics
https://www.readbyqxmd.com/read/29234007/insights-into-the-structure-and-assembly-of-a-bacterial-cellulose-secretion-system
#2
Petya Violinova Krasteva, Joaquin Bernal-Bayard, Laetitia Travier, Fernando Ariel Martin, Pierre-Alexandre Kaminski, Gouzel Karimova, Rémi Fronzes, Jean-Marc Ghigo
Secreted exopolysaccharides present important determinants for bacterial biofilm formation, survival, and virulence. Cellulose secretion typically requires the concerted action of a c-di-GMP-responsive inner membrane synthase (BcsA), an accessory membrane-anchored protein (BcsB), and several additional Bcs components. Although the BcsAB catalytic duo has been studied in great detail, its interplay with co-expressed subunits remains enigmatic. Here we show that E. coli Bcs proteins partake in a complex protein interaction network...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29233190/microvascular-effects-of-intravenous-esmolol-in-patients-with-normal-cardiac-function-undergoing-postoperative-atrial-fibrillation-a-prospective-pilot-study-in-cardiothoracic-surgery
#3
William Fornier, Matthias Jacquet-Lagrèze, Thomas Collenot, Priscilla Teixeira, Philippe Portran, Rémi Schweizer, Michel Ovize, Jean-Luc Fellahi
BACKGROUND: Postoperative atrial fibrillation (POAF) is commonplace after cardiothoracic surgery. A rate control strategy using short-acting beta blockers is recommended as a first-line therapy in patients without hemodynamic instability. Microcirculatory effects of POAF and esmolol have not yet been investigated. We hypothesized that POAF without hemodynamic instability would induce microvascular dysfunction which could be reversed by intravenous esmolol. METHODS: Twenty-five cardiothoracic surgical patients with POAF were included in the study...
December 12, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29231248/slurp-1-is-mutated-in-mal-de-meleda-a-potential-molecular-signature-for-melanoma-and-a-putative-squamous-lineage-tumor-suppressor-gene
#4
Christina Bergqvist, Humam Kadara, Lamiaa Hamie, Georges Nemer, Remi Safi, Mirna Karouni, Nadine Marrouche, Ossama Abbas, Divina J Hasbani, Abdul G Kibbi, Dany Nassar, Yutaka Shimomura, Mazen Kurban
BACKGROUND: Mal de Meleda (MDM) is a rare inherited autosomal recessive genodermatosis characterized by palmoplantar keratoderma (PPK) with transgrediens and caused by mutations in the SLURP1 gene. Uncommonly, cutaneous tumors have been found at PPK sites in MDM patients. OBJECTIVE: To study a Middle Eastern family with MDM with both PPK and skin tumors. METHODS: We studied a Middle Eastern (Palestinian) family with clinical features of MDM and cutaneous tumors...
December 12, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29231168/multiple-sources-of-slow-activity-fluctuations-in-a-bacterial-chemosensory-network
#5
Remy Colin, Christelle Rosazza, Ady Vaknin, Victor Sourjik
Cellular networks are intrinsically subject to stochastic fluctuations, but analysis of the resulting noise remained largely limited to gene expression. The pathway controlling chemotaxis of Escherichia coli provides one example where posttranslational signaling noise has been deduced from cellular behavior. This noise was proposed to result from stochasticity in chemoreceptor methylation, and it is believed to enhance environment exploration by bacteria. Here we combined single-cell FRET measurements with analysis based on the fluctuation-dissipation theorem (FDT) to characterize origins of activity fluctuations within the chemotaxis pathway...
December 12, 2017: ELife
https://www.readbyqxmd.com/read/29230672/the-role-of-b-cell-maturation-antigen-in-the-biology-and-management-of-and-as-a-potential-therapeutic-target-in-multiple-myeloma
#6
Eric Sanchez, Emily J Smith, Moryel A Yashar, Saurabh Patil, Mingjie Li, Autumn L Porter, Edward J Tanenbaum, Remy E Schlossberg, Camilia M Soof, Tara Hekmati, George Tang, Cathy S Wang, Haiming Chen, James R Berenson
B-cell maturation antigen (BCMA) was originally identified as a cell membrane receptor, expressed exclusively on late stage B-cells and plasma cells (PCs). Investigations of BCMA as a target for therapeutic intervention in multiple myeloma (MM) were initiated in 2007, using cSG1 as a naked antibody (Ab) as well as an Ab-drug conjugate (ADC) targeting BCMA, ultimately leading to ongoing clinical studies for previously treated MM patients. Since then, multiple companies have developed anti-BCMA-directed ADCs...
December 11, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/29230087/nest-design-in-a-changing-world-great-tit-parus-major-nests-from-a-mediterranean-city-environment-as-a-case-study
#7
Marcel M Lambrechts, Anne Charmantier, Virginie Demeyrier, Annick Lucas, Samuel Perret, Matthieu Abouladzé, Michel Bonnet, Coline Canonne, Virginie Faucon, Stéphanie Grosset, Gaëlle le Prado, Frédéric Lidon, Thierry Noell, Pascal Pagano, Vincent Perret, Stéphane Pouplard, Rémy Spitaliéry, Cyril Bernard, Philippe Perret, Jacques Blondel, Arnaud Grégoire
Investigations of urbanization effects on birds have focused mainly on breeding traits expressed after the nest-building stage (e.g. first-egg date, clutch size, breeding success, and offspring characteristics). Urban studies largely ignored how and why the aspects of nest building might be associated with the degree of urbanization. As urban environments are expected to present novel environmental changes relative to rural environments, it is important to evaluate how nest-building behavior is impacted by vegetation modifications associated with urbanization...
December 2017: Urban Ecosystems
https://www.readbyqxmd.com/read/29229952/ultra-bright-%C3%AE-ray-emission-and-dense-positron-production-from-two-laser-driven-colliding-foils
#8
Han-Zhen Li, Tong-Pu Yu, Jin-Jin Liu, Yan Yin, Xing-Long Zhu, Remi Capdessus, Francesco Pegoraro, Zheng-Ming Sheng, Paul McKenna, Fu-Qiu Shao
Matter can be transferred into energy and the opposite transformation is also possible by use of high-power lasers. A laser pulse in plasma can convert its energy into γ-rays and then e - e + pairs via the multi-photon Breit-Wheeler process. Production of dense positrons at GeV energies is very challenging since extremely high laser intensity ~1024 Wcm-2 is required. Here we propose an all-optical scheme for ultra-bright γ-ray emission and dense positron production with lasers at intensity of 1022-23 Wcm-2...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229634/genomic-insights-into-colistin-resistant-klebsiella-pneumoniae-from-a-tunisian-teaching-hospital
#9
Nadia Jaidane, Rémy A Bonnin, Wejdene Mansour, Delphine Girlich, Elodie Creton, Garance Colleton, Cherifa Chaouch, Noureddine Boujaafar, Olfa Bouallegue, Thierry Naas
The emergence of colistin-resistant Klebsiella pneumoniae (CoRKp) is a public health concern since this antibiotic has become the last line of treatment for infections caused by multidrug-resistant (MDR) gram-negatives. In this study, we have investigated the molecular basis of colistin-resistance in 13 MDR Kp isolated from 12 patients in a teaching hospital in Sousse, Tunisia. Whole-genome sequencing (WGS) was used to decipher the molecular mechanism of colistin-resistance and to identify the resistome of these CoRKp It revealed a genome of ca...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29229104/heart-rate-and-risk-of-death-among-patients-with-pulmonary-hypertension-a-12-lead-ecg-analysis
#10
Helene Bouchery-Bardet, Christian Creveuil, Fabrice Bauer, Farzin Beygui, Laure Champ-Rigot, Eric Saloux, Fabien Labombarda, Vincent Roule, Rémi Sabatier, Damien Legallois, Gérard Zalcman, Emmanuel Bergot, Paul Milliez
BACKGROUND: Despite the emergence of new therapies, Pulmonary Hypertension (PH) still has a high mortality. Several clinical, echocardiographic, biological or hemodynamic prognostic factors have been identified but are of limited predictive value for survival. We aimed to assess whether heart rate (HR) and all ECG abnormalities measured on a 12-lead ECG may help to better identify patients at high risk of death in this population. METHODS AND RESULTS: 296 patients followed in a registry were included with all types of PH, except group 2 of the WHO clinical classification...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29228505/a-spatio-temporal-exposure-hazard-model-for-assessing-biological-risk-and-impact
#11
Emily Walker, Melen Leclerc, Jean-François Rey, Rémy Beaudouin, Samuel Soubeyrand, Antoine Messéan
We developed a simulation model for quantifying the spatio-temporal distribution of contaminants (e.g., xenobiotics) and assessing the risk of exposed populations at the landscape level. The model is a spatio-temporal exposure-hazard model based on (i) tools of stochastic geometry (marked polygon and point processes) for structuring the landscape and describing the exposed individuals, (ii) a dispersal kernel describing the dissemination of contaminants from polygon sources, and (iii) an (eco)toxicological equation describing the toxicokinetics and dynamics of contaminants in affected individuals...
December 11, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29228314/demodifying-rna-for-transcriptomic-analyses-of-archival-formalin-fixed-paraffin-embedded-samples
#12
Leah C Wehmas, Charles E Wood, Remi Gagne, Andrew Williams, Carole Yauk, Mark M Gosink, Deidre Dalmas, Ruixin Hao, Raegan O'Lone, Susan Hester
Archival formalin-fixed paraffin-embedded (FFPE) tissue samples offer a vast but largely untapped resource for genomic research. The primary technical issues limiting use of FFPE samples are RNA yield and quality. In this study, we evaluated methods to demodify RNA highly fragmented and crosslinked by formalin fixation. Primary endpoints were RNA recovery, RNA-sequencing quality metrics, and transcriptional responses to a reference chemical (phenobarbital, PB). Frozen mouse liver samples from control and PB groups (n = 6/group) were divided and preserved for 3 months as follows: frozen (FR); 70% ethanol (OH); 10% buffered formalin for 18 hours followed by ethanol (18F); or 10% buffered formalin (3F)...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29228171/gene-graphics-a-genomic-neighborhood-data-visualization-web-application
#13
Katherine J Harrison, Valérie de Crécy-Lagard, Rémi Zallot
Summary: The examination of gene neighborhood is an integral part of comparative genomics but no tools to produce publication quality graphics of gene clusters are available. Gene Graphics is a straightforward web application for creating such visuals. Supported inputs include National Center for Biotechnology Information (NCBI) gene and protein identifiers with automatic fetching of neighboring information, GenBank files and data extracted from the SEED database. Gene representations can be customized for many parameters including gene and genome names, colors and sizes...
December 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29226117/pediatric-anti-n-methyl-d-aspartate-receptor-encephalitis-a-review-with-pooled-analysis-and-critical-care-emphasis
#14
REVIEW
Kenneth E Remy, Jason W Custer, Joshua Cappell, Cortney B Foster, Nan A Garber, L Kyle Walker, Liliana Simon, Dayanand Bagdure
Purpose: Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is being recognized with increasing frequency among children. Given the paucity of evidence to guide the critical care management of these complex patients, we provide a comprehensive review of the literature with pooled analysis of published case reports and case series. Methods: We performed a comprehensive literature search using PubMed, Scopus, EMBASE, and Web of Science for relevant published studies...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29224132/treatment-of-mild-to-moderate-hypoglycemia-in-patients-with-type-1-diabetes-treated-with-insulin-pump-therapy-are-current-recommendations-effective
#15
Véronique Gingras, Katherine Desjardins, Mohamed Raef Smaoui, Valérie Savard, Virginie Messier, Ahmad Haidar, Laurent Legault, Rémi Rabasa-Lhoret
AIMS: Mild-to-moderate hypoglycemia (blood glucose < 4.0 mmol/L) is recommended to be treated with 15 g of carbohydrates and to repeat the treatment if hypoglycemia persists after 15 min. This recommendation was established before intensive insulin therapy and based on studies using insulin with different pharmacokinetic profiles from actual insulin analogs showing that 15 g of glucose increases blood glucose by ~ 1.5 mmol/L in 15 min. We aimed to explore the effect of current recommended treatment of mild-to-moderate hypoglycemia in type 1 diabetes (T1D) participants and factors associated with treatment effectiveness...
December 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29224050/maldi-imaging-combined-with-laser-microdissection-based-microproteomics-for-protein-identification-application-to-intratumor-heterogeneity-studies
#16
Rémi Longuespée, Deborah Alberts, Dominique Baiwir, Gabriel Mazzucchelli, Nicolas Smargiasso, Edwin De Pauw
Matrix-assisted laser desorption ionization (MALDI) imaging is widely used for in situ proteomic mapping and finds multiple applications in pathology. However, low fragmentation yields in MALDI avoid an optimal identification of peptides from tissues. On the other hand, LMD-based microproteomic analyses allow for the identification of hundreds to thousands of proteins from small tissue regions. Herein, we present the combination of MALDI imaging and LMD-based microproteomic approaches for parallel identification...
December 10, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222850/exploratory-study-of-imagery-rescripting-without-focusing-on-early-traumatic-memories-for-major-depressive-disorder
#17
Fuminori Yamada, Yoichi Hiramatsu, Tomokazu Murata, Yoichi Seki, Mizue Yokoo, Remi Noguchi, Takayuki Shibuya, Mari Tanaka, Rieko Takanashi, Eiji Shimizu
BACKGROUND: Mental imagery has a more powerful impact on our emotions than thinking in words about the same material. Treating intrusive images with imagery rescripting (IR) has been reported for various disorders, including post-traumatic stress disorder, social anxiety disorder, and bipolar disorder. There has been less research about IR as a major depressive disorder (MDD). AIMS: We examined whether IR without focusing on early traumatic memories is effective in MDD...
December 9, 2017: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/29220487/ancestral-genome-estimation-reveals-the-history-of-ecological-diversification-in-agrobacterium
#18
Florent Lassalle, Rémi Planel, Simon Penel, David Chapulliot, Valérie Barbe, Audrey Dubost, Alexandra Calteau, David Vallenet, Damien Mornico, Thomas Bigot, Laurent Guéguen, Ludovic Vial, Daniel Muller, Vincent Daubin, Xavier Nesme
Horizontal gene transfer (HGT) is considered as a major source of innovation in bacteria, and as such is expected to drive adaptation to new ecological niches. However, among the many genes acquired through HGT along the diversification history of genomes, only a fraction may have actively contributed to sustained ecological adaptation. We used a phylogenetic approach accounting for the transfer of genes (or groups of genes) to estimate the history of genomes in Agrobacterium biovar 1, a diverse group of soil and plant-dwelling bacterial species...
December 6, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29219379/optimizing-hyperuniformity-in-self-assembled-bidisperse-emulsions
#19
Joshua Ricouvier, Romain Pierrat, Rémi Carminati, Patrick Tabeling, Pavel Yazhgur
We study long range density fluctuations (hyperuniformity) in two-dimensional jammed packings of bidisperse droplets. Taking advantage of microfluidics, we systematically span a large range of size and concentration ratios of the two droplet populations. We identify various defects increasing long range density fluctuations mainly due to organization of local particle environment. By choosing an appropriate bidispersity, we fabricate materials with a high level of hyperuniformity. Interesting transparency properties of these optimized materials are established based on numerical simulations...
November 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29216093/140%C3%A2-%C3%A2-%C3%AE-m-single-polarization-passive-fully-aperiodic-large-pitch-fibers-operating-near-2%C3%A2-%C3%AE-m
#20
Dia Darwich, Mostafa Sabra, Remi du Jeu, Marie-Alicia Malleville, Romain Dauliat, Raphaël Jamier, Aurélien Benoit, Kay Schuster, Philippe Roy
In this paper, we demonstrate a single-polarization feature out of passive very-large-mode-area fully aperiodic large-pitch fibers. It has been previously shown theoretically that one of the two polarizations of the fundamental mode is selectively coupled to a cladding mode. This coupling does not require fiber bending, which permits us to avoid any decrease in mode effective area. The coupling is achieved owing to boron-doped silica inclusions implemented into the microstructured cladding and acting as stress-applying parts...
November 20, 2017: Applied Optics
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