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https://www.readbyqxmd.com/read/29906573/store-depletion-induced-h-channel-plasticity-rescues-a-channelopathy-linked-to-alzheimer-s-disease
#1
Timothy F Musial, Elizabeth Molina-Campos, Linda A Bean, Natividad Ybarra, Ronen Borenstein, Matthew L Russo, Eric W Buss, Daniel Justus, Krystina M Neuman, Gelique D Ayala, Sheila A Mullen, Yuliya Voskobiynyk, Christopher T Tulisiak, Jasmine A Fels, Nicola J Corbett, Gabriel Carballo, Colette D Kennedy, Jelena Popovic, Josefina Ramos-Franco, Michael Fill, Melissa R Pergande, Jeffrey A Borgia, Grant T Corbett, Kalipada Pahan, Ye Han, Dane M Chetkovich, Robert J Vassar, Richard W Byrne, M Matthew Oh, Travis R Stoub, Stefan Remy, John F Disterhoft, Daniel A Nicholson
Voltage-gated ion channels are critical for neuronal integration. Some of these channels, however, are misregulated in several neurological disorders, causing both gain- and loss-of-function channelopathies in neurons. Using several transgenic mouse models of Alzheimer's disease (AD), we find that sub-threshold voltage signals strongly influenced by hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels progressively deteriorate over chronological aging in hippocampal CA1 pyramidal neurons. The progressively degraded signaling via HCN channels in the transgenic mice is accompanied by an age-related global loss of their non-uniform dendritic expression...
June 12, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29904181/relativistic-doppler-boosted-%C3%AE-rays-in-high-fields
#2
Remi Capdessus, Martin King, Dario Del Sorbo, Matthew Duff, Christopher P Ridgers, Paul McKenna
The relativistic Doppler effect is one of the most famous implications of the principles of special relativity and is intrinsic to moving radiation sources, relativistic optics and many astrophysical phenomena. It occurs in the case of a plasma sail accelerated to relativistic velocities by an external driver, such as an ultra-intense laser pulse. Here we show that the relativistic Doppler effect on the high energy synchrotron photon emission (~10 MeV), strongly depends on two intrinsic properties of the plasma (charge state and ion mass) and the transverse extent of the driver...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29903592/intravenous-catheters-induce-a-local-inflammatory-response
#3
Katherine Chabot, Marie-Eve Lavoie, Jean-Philippe Bastard, Rémi Rabasa-Lhoret
AIM: Chronic inflammation has been associated to the development of cardiometabolic dysfunctions. The use of an intravenous (IV) catheter is highly recommended for physiology testing. Yet, the presence of an IV catheter triggers local inflammation that does not reflect systemic inflammatory status. The aim of this study was to assess the effect of an IV catheter on serum concentrations of IL-6, IL-8 and hsCRP in a fasting state and after a high-fat meal known to trigger low-grade inflammation...
June 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29900832/-multi-omic-approaches-reveal-new-therapeutic-targets-for-the-treatment-of-pancreatic-cancer
#4
Rémy Nicolle, Yuna Blum, Laetitia Marisa, Nelson Dusetti, Juan Iovanna
No abstract text is available yet for this article.
May 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29898956/congenital-macrothrombocytopenia-with-focal-myelofibrosis-due-to-mutations-in-human-g6b-b-is-rescued-in-humanized-mice
#5
Inga Hofmann, Mitchell J Geer, Timo Vögtle, Andrew Crispin, Dean R Campagna, Alastair Barr, Monica L Calicchio, Silke Heising, Johanna P van Geffen, Marijke J E Kuijpers, Johan W M Heemskerk, Johannes A Eble, Klaus Schmitz-Abe, Esther A Obeng, Michael Douglas, Kathleen Freson, Corinne Pondarré, Rémi Favier, Gavin E Jarvis, Kyriacos Markianos, Ernest Turro, Willem H Ouwehand, Alexandra Mazharian, Mark D Fleming, Yotis A Senis
Unlike primary myelofibrosis (PMF) in adults, myelofibrosis in children is rare. Congenital (inherited) forms of myelofibrosis (cMF) have been described, but the underlying genetic mechanisms remain elusive. Here we describe 4 families with autosomal recessive inherited macrothrombocytopenia with focal myelofibrosis due to germline loss-of-function mutations in the megakaryocyte-specific immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor G6b-B (G6b, C6orf25 or MPIG6B). Patients presented with a mild-to-moderate bleeding diathesis, macrothrombocytopenia, anemia, leukocytosis and atypical megakaryocytes associated with a distinctive, focal, perimegakaryocytic pattern of bone marrow fibrosis...
June 13, 2018: Blood
https://www.readbyqxmd.com/read/29897597/high-frequency-neuronavigated-rtms-in-auditory-verbal-hallucinations-a-pilot-double-blind-controlled-study-in-patients-with-schizophrenia
#6
Sonia Dollfus, Nemat Jaafari, Olivier Guillin, Benoit Trojak, Marion Plaze, Ghassen Saba, Cécilia Nauczyciel, Aurélie Montagne Larmurier, Nathalie Chastan, Vincent Meille, Marie-Odile Krebs, Samar S Ayache, Jean Pascal Lefaucheur, Annick Razafimandimby, Elise Leroux, Rémy Morello, Jean Marie Batail, Perrine Brazo, Nicolas Lafay, Issa Wassouf, Ghina Harika-Germaneau, Remy Guillevin, Carole Guillevin, Emmanuel Gerardin, Maud Rotharmel, Benoit Crépon, Raphael Gaillard, Christophe Delmas, Gael Fouldrin, Guillaume Laurent, Clément Nathou, Olivier Etard
INTRODUCTION: Despite extensive testing, the efficacy of low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) of temporo-parietal targets for the treatment of auditory verbal hallucinations (AVH) in patients with schizophrenia is still controversial, but promising results have been reported with both high-frequency and neuronavigated rTMS. Here, we report a double-blind sham-controlled study to assess the efficacy of high-frequency (20 Hz) rTMS applied over a precise anatomical site in the left temporal region using neuronavigation...
April 6, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29896112/a-systematic-review-of-the-complex-effects-of-cannabinoids-on-cerebral-and-peripheral-circulation-in-animal-models
#7
REVIEW
J Sebastian Richter, Véronique Quenardelle, Olivier Rouyer, Jean Sébastien Raul, Rémy Beaujeux, Bernard Gény, Valérie Wolff
While cannabis is perceived as a relatively safe drug by the public, accumulating clinical data suggest detrimental cardiovascular effects of cannabinoids. Cannabis has been legalized in several countries and jurisdictions recently. Experimental studies specifically targeting cannabinoids' effects on the cerebral vasculature are rare. There is evidence for transient vasoconstrictive effects of cannabinoids in the peripheral and cerebral vasculature in a complex interplay of vasodilation and vasoconstriction...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29895884/europe-wide-reassessment-of-dictyocoela-microsporidia-infecting-native-and-invasive-amphipods-crustacea-molecular-versus-ultrastructural-traits
#8
Karolina Bacela-Spychalska, Piotr Wróblewski, Tomasz Mamos, Michał Grabowski, Thierry Rigaud, Remi Wattier, Tomasz Rewicz, Alicja Konopacka, Mykola Ovcharenko
Microsporidia are common parasites infecting animals and protists. They are specifically common pathogens of amphipods (Crustacea, Malacostraca), with Dictyocoela spp. being particularly frequent and highly prevalent, exhibiting a range of phenotypic and ecological effects. Until now, seven species of Dictyocoela were defined, predominantly based on the genetic distance. However, neither the taxonomic status of this provisionally erected genus (based on eight novel sequences and one micrograph of the spore), nor its internal phylogenetic relationships have been clearly revealed...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29895865/a-potential-new-role-for-myofibroblasts-in-remodeling-of-sub-rupture-fatigue-tendon-injuries-by-exercise
#9
Rebecca Bell, N Remi Gendron, Matthew Anderson, Evan L Flatow, Nelly Andarawis-Puri
Tendons are ineffective at repairing sub-rupture fatigue injuries. Accordingly, we evaluated whether an exercise protocol that we have previously found to decrease structural damage kinks in fatigue damaged tendons, leads to improvement in mechanical properties. We hypothesized that exercise that promotes repair of fatigue damage will decrease apoptosis and increase the population of myofibroblasts. Rat patellar tendons underwent in vivo fatigue loading for 500 or 7200 cycles. Animals resumed cage activity for 2-weeks, then either remained cage active or began treadmill running until sacrifice at 4- or 10-weeks post-fatigue loading...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29895670/cerebellar-synapse-properties-and-cerebellum-dependent-motor-and-non-motor-performance-in-dp71-null-mice
#10
Romain Helleringer, Delphine Le Verger, Xia Li, Charlotte Izabelle, Rémi Chaussenot, Mehdi Belmaati-Cherkaoui, Raoudha Dammak, Paulette Decottignies, Hervé Daniel, Micaela Galante, Cyrille Vaillend
A recent focus has been placed on the role that cerebellar dysfunctions could play in the genesis of cognitive deficits in Duchenne muscular dystrophy (DMD). However, relevant genotype-phenotype analyses are missing to define whether cerebellar defects underlie the severe cases of intellectual deficiency, which have been associated with genetic loss of the smallest product of the dmd gene, the Dp71 dystrophin. To determine for the first time whether Dp71 loss could affect cerebellar physiology and functions, we have used patch-clamp electrophysiological recordings in acute cerebellar slices and a cerebellum-dependent behavioral test battery addressing cerebellum-dependent motor and non-motor functions in Dp71-null transgenic mice...
June 12, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29895424/response-to-cardiac-resynchronization-therapy-is-determined-by-intrinsic-electrical-substrate-rather-than-by-its-modification
#11
Marc Strik, Sylvain Ploux, Peter R Huntjens, Uyên Châu Nguyên, Antionio Frontera, Romain Eschalier, Remi Dubois, Philippe Ritter, Nicholas Klotz, Kevin Vernooy, Michel Haïssaguerre, Harry J G M Crijns, Frits W Prinzen, Pierre Bordachar
BACKGROUND: Electrocardiographic mapping (ECM) expresses electrical substrate through magnitude and direction of the activation delay vector (ADV). We investigated to what extent the response to cardiac resynchronization therapy (CRT) is determined by baseline ADV and by ADV modification through CRT and optimization of left ventricular (LV) pacing site. METHODS: ECM was performed in 79 heart failure patients (4 RBBB, 12 QRS < 120 ms, 23 non-specific conduction delay [NICD] and 40 left bundle branch block [LBBB])...
June 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29892608/mortality-in-neuromyelitis-optica-is-strongly-associated-with-african-ancestry
#12
Maureen A Mealy, Remi A Kessler, Zoe Rimler, Allyson Reid, Lauren Totonis, Gary Cutter, Ilya Kister, Michael Levy
No abstract text is available yet for this article.
July 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29891208/evaluation-of-six-diffusion-weighted-mri-models-for-assessing-effects-of-neoadjuvant-chemoradiation-in-pancreatic-cancer-patients
#13
Remy Klaassen, Oliver J Gurney-Champion, Marc R W Engelbrecht, Jaap Stoker, Johanna W Wilmink, Marc G Besselink, Arjan Bel, Geertjan van Tienhoven, Hanneke W M van Laarhoven, Aart J Nederveen
PURPOSE: To compare 6 diffusion-weighted imaging (DWI) MRI models for response evaluation in patients with pancreatic ductal adenocarcinoma (PDAC). MATERIALS AND METHODS: DWI images were acquired at 3T for b = 0-600 s/mm2 in fourteen patients with advanced PDAC during 2 separate pretreatment sessions and 9 patients with (borderline) resectable PDAC pre and post neoadjuvant chemoradiation. Data was fitted with a mono-exponential (ADC), double mono-exponential to b = 0 and 100 s/mm2 (ADCfast ), and b = 100 and 600 s/mm2 (ADCslow ), IVIM model with D* free (D, f, D*) and fixed (D, f), tri-exponent (D, f1 , f2 ), and stretched exponent model (DDC, α)...
May 4, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29890615/respiratory-condition-of-family-farmers-exposed-to-pesticides-in-the-state-of-rio-de-janeiro-brazil
#14
Rafael J Buralli, Helena Ribeiro, Thais Mauad, Luís F Amato-Lourenço, João M Salge, Fredi A Diaz-Quijano, Renata S Leão, Rejane C Marques, Daniele S Silva, Jean Remy Davée Guimarães
Pesticide exposure is a growing public health concern. Although Brazil is the world&rsquo;s largest consumer of pesticides, only a few studies have addressed the health effects among farmers. This study aimed to evaluate whether pesticide exposure is associated with respiratory outcomes among rural workers and relatives in Brazil during the crop and off-seasons. Family farmers (82) were interviewed about occupational history and respiratory symptoms, and cholinesterase tests were conducted in the crop-season...
June 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29890172/optimization-of-primary-drying-in-lyophilization-during-early-phase-drug-development-using-a-definitive-screening-design-with-formulation-and-process-factors
#15
Johnathan M Goldman, Haresh T More, Olga Yee, Elizabeth Borgeson, Brenda Remy, Jasmine Rowe, Vikram Sadineni
Development of optimal drug product lyophilization cycles is typically accomplished via multiple engineering runs to determine appropriate process parameters. These runs require significant time and product investments, which are especially costly during early phase development when the drug product formulation and lyophilization process are often defined simultaneously. Even small changes in the formulation may require a new set of engineering runs to define lyophilization process parameters. In order to overcome these development difficulties, an eight factor definitive screening design (DSD), including both formulation and process parameters, was executed on a fully human monoclonal antibody (mAb) drug product...
June 8, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29885749/corrigendum-to-trimage-a-dedicated-trimodality-pet-mr-eeg-imaging-tool-for-schizophrenia-eur-psychiatry-50-2018-7-20
#16
Alberto Del Guerra, Salleh Ahmad, Mihai Avram, Nicola Belcari, Arne Berneking, Laura Biagi, Maria Giuseppina Bisogni, Felix Brandl, Jorge Cabello, Niccolò Camarlinghi, Piergiorgio Cerello, Chang-Hoon Choi, Silvia Coli, Sabrina Colpo, Julien Fleury, Vito Gagliardi, Giuseppe Giraudo, Karsten Heekeren, Wolfram Kawohl, Theodora Kostou, Jean-Luc Lefaucheur, Christoph Lerche, George Loudos, Matteo Morrocchi, Julien Muller, Mona Mustafa, Irene Neuner, Panagiotis Papadimitroulas, Francesco Pennazio, Ravichandran Rajkumar, Cláudia Régio Brambilla, Julien Rivoire, Elena Rota Kops, Jürgen Scheins, Rémy Schimpf, N Jon Shah, Christian Sorg, Giancarlo Sportelli, Michela Tosetti, Riccardo Trinchero, Christine Wyss, Sibylle Ziegler
No abstract text is available yet for this article.
June 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29885372/posterior-c1c2-harms-fusion-with-3d-surgical-navigation
#17
Mourad Ould-Slimane, François-Xavier Ferracci, Sébastien Le Pape, Alexis Perrez, Paul Michelin, Rémi Gauthé
Several types of atlantoaxial instability can justify surgical fixation. The instrumented fusion procedure described by Harms with screw fixation of the C1 lateral masses and C2 pedicles is a demanding technique that provides lasting stabilization. However, it has been associated with nerve and vascular complications due to the local anatomical configuration. Surgical navigation systems can help improve the procedure's accuracy. We describe a series of 11 cases of C1C2 Harms fusion performed with surgical navigation and intraoperative 3D imaging checks...
June 6, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29882597/experimental-demonstration-of-the-impact-of-hard-and-soft-selection-regimes-on-polymorphism-maintenance-in-spatially-heterogeneous-environments
#18
Romain Gallet, Rémy Froissart, Virginie Ravigné
Predicting and managing contemporary adaption requires a proper understanding of the determinants of genetic variation. Spatial heterogeneity of the environment may stably maintain polymorphism when habitat contribution to the next generation can be considered independent of the degree of adaptation of local populations within habitats (i.e., under soft selection). In contrast, when habitats contribute proportionally to the mean fitness of the populations they host (hard selection), polymorphism is not expected to be maintained by selection...
June 8, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29879312/effect-of-a-gonadotropin-releasing-hormone-analog-for-ovarian-function-preservation-after-intravenous-cyclophosphamide-therapy-in-systemic-lupus-erythematosus-patients-a-retrospective-inception-cohort-study
#19
Tomohiro Koga, Masataka Umeda, Yushiro Endo, Midori Ishida, Yuya Fujita, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Remi Sumiyoshi, Takashi Igawa, Shoichi Fukui, Ayako Nishino, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Naoko Murakami, Michio Kitajima, Atsushi Kawakami
OBJECTIVE: To determine the effect of leuprolide acetate, a synthetic gonadotropin-releasing hormone analog (GnRH-a) on ovarian function preservation in systemic lupus erythematosus (SLE) patients treated with cyclophosphamide (CYC) in clinical practice. METHODS: We enrolled 30 premenopausal female SLE patients who fulfilled the 1997 American College of Rheumatology revised criteria and were treated with intravenous CYC (IVCY) in 2008-2017. We used Kaplan-Meier survival estimates to compare the GnRH-a-treated patients and those not treated with GnRH-a as controls...
June 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29879170/elimination-or-more-accurate-estimation-investigation-of-trends-in-malaria-diagnoses-in-the-ouest-department-of-haiti-from-2008-to-2017
#20
Thomas A Weppelmann, Caroline J Stephenson, Elisha Musih, John B Dame, Marie Y Remy, Robert Nicolas, Michael E von Fricken
BACKGROUND: According to the 2016 World Malaria Report, the malaria incidence in Haiti declined by > 40% between 2010 and 2015. Though elimination efforts have likely contributed, this time period also corresponded to a national change in diagnostic methods. METHODS: Monthly reports of aggregated patient data were acquired from five clinics in the Ouest Department of Haiti. Generalized linear models were used to compare the number of febrile patients tested, the number of positive tests, and the proportion of tests that were positive (TRP) before and after the national adoption of rapid diagnostic tests (RDTs)...
2018: PloS One
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