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https://www.readbyqxmd.com/read/28240745/the-biological-and-prognostic-significance-of-angiotropism-in-uveal-melanoma
#1
Raymond L Barnhill, Mengliang Ye, Aude Batistella, Marc-Henri Stern, Sergio Roman-Roman, Rémi Dendale, Olivier Lantz, Sophie Piperno-Neumann, Laurence Desjardins, Nathalie Cassoux, Claire Lugassy
Angiotropism is a marker of extravascular migration of melanoma cells along vascular and other structures and a prognostic factor in cutaneous melanoma. Because of this biological and prognostic importance in cutaneous melanoma, angiotropism was studied in uveal melanoma (UM). This retrospective study performed at a single ocular oncology referral center included 89 patients from the study period 2006-2008. All patients were diagnosed with UM from the choroid and/or ciliary body. All patients underwent enucleation for prognostic purposes and definitive therapy...
February 27, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28239762/-1-h-13-c-and-15-n-backbone-chemical-shift-assignments-of-camelid-single-domain-antibodies-against-active-state-%C3%A2%C2%B5-opioid-receptor
#2
Remy Sounier, Yinshan Yang, Joanna Hagelberger, Sébastien Granier, Hélène Déméné
Nanobodies are single chain antibodies that have become a highly valuable and versatile tool for biomolecular and therapeutic research. One application field is the stabilization of active states of flexible proteins, among which G-protein coupled receptors represent a very important class of membrane proteins. Here we present the backbone and side-chain assignment of the (1)H, (13)C and (15)N resonances of Nb33 and Nb39, two nanobodies that recognize and stabilize the µ-opioid receptor to opioids in its active agonist-bound conformation...
February 26, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28236715/the-association-of-sleep-and-physical-activity-with-integrity-of-white-matter-microstructure-in-bipolar-disorder-patients-and-healthy-controls
#3
Sanne Verkooijen, Remi Stevelink, Lucija Abramovic, Christiaan H Vinkers, Roel A Ophoff, René S Kahn, Marco P M Boks, Neeltje E M van Haren
We investigate how the sleep disruptions and irregular physical activity levels that are prominent features of bipolar disorder (BD) relate to white matter microstructure in patients and controls. Diffusion tension imaging (DTI) and 14-day actigraphy recordings were obtained in 51 BD I patients and 55 age-and-gender-matched healthy controls. Tract-based spatial statistics (TBSS) was used for voxelwise analysis of the association between fractional anisotropy (FA) and sleep and activity characteristics in the overall sample...
February 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28236014/the-smartor-a-distributed-sensor-network-to-improve-operating-room-efficiency
#4
Albert Y Huang, Guillaume Joerger, Vid Fikfak, Remi Salmon, Brian J Dunkin, Barbara L Bass, Marc Garbey
BACKGROUND: Despite the significant expense of OR time, best practice achieves only 70% efficiency. Compounding this problem is a lack of real-time data. Most current OR utilization programs require manual data entry. Automated systems require installation and maintenance of expensive tracking hardware throughout the institution. This study developed an inexpensive, automated OR utilization system and analyzed data from multiple operating rooms. STUDY DESIGN: OR activity was deconstructed into four room states...
February 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28235866/rab11-fip3-regulation-of-lck-endosomal-traffic-controls-tcr-signal-transduction
#5
Jérôme Bouchet, Iratxe Del Río-Iñiguez, Elena Vázquez-Chávez, Rémi Lasserre, Sonia Agüera-González, Céline Cuche, Mary W McCaffrey, Vincenzo Di Bartolo, Andrés Alcover
The role of endosomes in receptor signal transduction is a long-standing question, which remains largely unanswered. The T cell Ag receptor and various components of its proximal signaling machinery are associated with distinct endosomal compartments, but how endosomal traffic affects T cell signaling remains ill-defined. In this article, we demonstrate in human T cells that the subcellular localization and function of the protein tyrosine kinase Lck depends on the Rab11 effector FIP3 (Rab11 family interacting protein-3)...
February 24, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28235695/the-differential-effects-of-prolonged-exercise-upon-executive-function-and-cerebral-oxygenation
#6
Gavin D Tempest, Karen Davranche, Jeanick Brisswalter, Stephane Perrey, Rémi Radel
The acute-exercise effects upon cognitive functions are varied and dependent upon exercise duration and intensity, and the type of cognitive tasks assessed. The hypofrontality hypothesis assumes that prolonged exercise, at physiologically challenging intensities, is detrimental to executive functions due to cerebral perturbations (indicated by reduced prefrontal activity). The present study aimed to test this hypothesis by measuring oxygenation in prefrontal and motor regions using near-infrared spectroscopy during two executive tasks (flanker task and 2-back task) performed while cycling for 60min at a very low intensity and an intensity above the ventilatory threshold...
February 14, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28231031/different-serological-profiles-to-cooccurring-pathogenic-and-nonpathogenic-caliciviruses-in-wild-european-rabbits-oryctolagus-cuniculus-across-australia
#7
Tanya E Cox, June Liu, Remy van de Ven, Tanja Strive
Rabbit hemorrhagic disease virus (RHDV) was released in Australia as a biocontrol agent for wild European rabbits ( Oryctolagus cuniculus ) in 1995-96; however, its effects were variable across Australia with the greatest population reductions seen in lower annual rainfall areas (<400 mm). There is speculation that the reduced effectiveness observed at higher annual rainfall sites is at least partially due to the presence of a nonpathogenic calicivirus (RCV-A1). The RCV-A1 is related to RHDV and confers partial and transient protection against lethal RHDV infection in laboratory tests...
February 23, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28231020/could-niv-failure-rates-be-underestimated-in-the-lung-safe-study
#8
Rémi Coudroy, Jean-Pierre Frat, Arnaud W Thille
No abstract text is available yet for this article.
February 23, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28229479/sampling-strategies-for-evaluating-the-rate-of-adventitious-transgene-presence-in-non-genetically-modified-crop-fields
#9
David Makowski, Rémi Bancal, Arnaud Bensadoun, Hervé Monod, Antoine Messéan
According to E.U. regulations, the maximum allowable rate of adventitious transgene presence in non-genetically modified (GM) crops is 0.9%. We compared four sampling methods for the detection of transgenic material in agricultural non-GM maize fields: random sampling, stratified sampling, random sampling + ratio reweighting, random sampling + regression reweighting. Random sampling involves simply sampling maize grains from different locations selected at random from the field concerned. The stratified and reweighting sampling methods make use of an auxiliary variable corresponding to the output of a gene-flow model (a zero-inflated Poisson model) simulating cross-pollination as a function of wind speed, wind direction, and distance to the closest GM maize field...
February 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28224302/retinal-cavernous-haemangioma-treated-by-proton-beam-therapy
#10
Amir Mahdjoubi, Rémi Dendale, Livia Lumbroso-Le Rouic, Laurence Desjardins, Nathalie Cassoux
As one of intraocular tumours, retinal cavernous haemangioma is a benign vascular lesion that is mostly unilateral. Very few cases about cavernous haemangioma treatment are reported, and there is currently no consensus on the most effective treatment. This clinical case reports on a 40-year-old male, presenting a peripheral retinal cavernous haemangioma, complicated with a repetitive vitreous haemorrhage causing bad vision. Several therapeutic methods were unsuccessfully attempted to stop haemorrhagic recurrences...
February 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28222071/combination-of-the-histone-deacetylase-inhibitor-vorinostat-with-bevacizumab-in-patients-with-clear-cell-renal-cell-carcinoma-a-multicentre-single-arm-phase-i-ii-clinical-trial
#11
Roberto Pili, Glenn Liu, Sreenivasulu Chintala, Hendrick Verheul, Shabnam Rehman, Kristopher Attwood, Martin A Lodge, Richard Wahl, James I Martin, Kiersten Marie Miles, Silvia Paesante, Remi Adelaiye, Alejandro Godoy, Serina King, James Zwiebel, Michael A Carducci
BACKGROUND: Class II histone deacetylase (HDAC) inhibitors induce hypoxia-inducible factor-1 and -2α degradation and have antitumour effects in combination with vascular endothelial growth factor (VEGF) inhibitors. In this study, we tested the safety and efficacy of the HDAC inhibitor vorinostat and the VEGF blocker bevacizumab in metastatic clear-cell renal cell carcinoma (ccRCC) patients previously treated with different drugs including sunitinib, sorafenib, axitinib, interleukin-2, interferon, and temsirolimus...
February 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28221714/photonic-devices-out-of-equilibrium-transient-memory-signal-propagation-and-sensing
#12
Thomas Heuser, Rémi Merindol, Sebastian Loescher, Aileen Klaus, Andreas Walther
Soft photonic materials are important for sensors, displays, or energy management and have become switchable under static equilibrium conditions by integration of responsive polymer features. The next step is to equip such materials with the ability for autonomously dynamic and self-regulating behavior, which would advance their functionality and application possibilities to new levels. Here, this study shows the system integration of a nonlinear, biocatalytic pH-feedback system with a pH-responsive block copolymer photonic gel, and demonstrates autonomous transient memories, remotely controlled signal propagation, and sensing...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28220883/reducing-luminance-intensity-can-improve-motion-perception-in-noise
#13
Rémy Allard, Angelo Arleo
Visual perception generally improves under brighter environments. For instance, motion sensitivity is known to improve with luminance intensity especially at high temporal frequencies. However, the current study counter-intuitively shows that increasing luminance intensity can impair motion sensitivity in noise. Motion sensitivity was measured with and without noise added to a drifting Gabor patch as a function of the temporal frequency and luminance intensity. As expected, motion sensitivity in absence of noise reached a ceiling performance at a relatively low luminance intensity (about 35 td) for low temporal frequencies and improved with luminance intensity up to the highest luminance intensity tested (353 td) for high temporal frequencies...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220842/image-processing-in-digital-pathology-an-opportunity-to-solve-inter-batch-variability-of-immunohistochemical-staining
#14
Yves-Rémi Van Eycke, Justine Allard, Isabelle Salmon, Olivier Debeir, Christine Decaestecker
Immunohistochemistry (IHC) is a widely used technique in pathology to evidence protein expression in tissue samples. However, this staining technique is known for presenting inter-batch variations. Whole slide imaging in digital pathology offers a possibility to overcome this problem by means of image normalisation techniques. In the present paper we propose a methodology to objectively evaluate the need of image normalisation and to identify the best way to perform it. This methodology uses tissue microarray (TMA) materials and statistical analyses to evidence the possible variations occurring at colour and intensity levels as well as to evaluate the efficiency of image normalisation methods in correcting them...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219008/nanoroughness-strongly-impacts-lipid-mobility-in-supported-membranes
#15
Florence Blachon, Frédéric Harb, Bogdan Munteanu, Agnès Piednoir, Rémy Fulcrand, Thierry Charitat, Giovanna Fragneto, Olivier Pierre-Louis, Bernard Tinland, Jean-Paul Rieu
In vivo lipid membranes interact with rough supramolecular structures such as protein clusters and fibrils. How these features whose size ranges from a few nanometers to a few tens of nanometers impact lipid and protein mobility is still being investigated. Here, we study supported phospholipid bilayers, a unique biomimetic model, deposited on etched surfaces bearing nanometric corrugations. The surface roughness and mean curvature are carefully characterized by AFM imaging using ultrasharp tips. Neutron specular reflectivity supplements this surface characterization and indicates that the bilayers follow the large-scale corrugations of the substrate...
February 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28218624/loss-of-microrna-7a2-induces-hypogonadotropic-hypogonadism-and-infertility
#16
Kashan Ahmed, Mary P LaPierre, Emanuel Gasser, Rémy Denzler, Yinjie Yang, Thomas Rülicke, Jukka Kero, Mathieu Latreille, Markus Stoffel
MicroRNAs (miRNAs) are negative modulators of gene expression that fine-tune numerous biological processes. miRNA loss-of-function rarely results in highly penetrant phenotypes, but rather, influences cellular responses to physiologic and pathophysiologic stresses. Here, we have reported that a single member of the evolutionarily conserved miR-7 family, miR-7a2, is essential for normal pituitary development and hypothalamic-pituitary-gonadal (HPG) function in adulthood. Genetic deletion of mir-7a2 causes infertility, with low levels of gonadotropic and sex steroid hormones, small testes or ovaries, impaired spermatogenesis, and lack of ovulation in male and female mice, respectively...
February 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28216062/nalmefene-reduces-reward-anticipation-in-alcohol-dependence-an-experimental-functional-magnetic-resonance-imaging-study
#17
Darren R Quelch, Inge Mick, John McGonigle, Anna C Ramos, Remy S A Flechais, Mark Bolstridge, Eugenii Rabiner, Matthew B Wall, Rexford D Newbould, Björn Steiniger-Brach, Franz van den Berg, Malcolm Boyce, Dorrit Østergaard Nilausen, Lasse Breuning Sluth, Didier Meulien, Christoph von der Goltz, David Nutt, Anne Lingford-Hughes
BACKGROUND: Nalmefene is a µ- and δ-opioid receptor antagonist, κ-opioid receptor partial agonist that has recently been approved in Europe for treating alcohol dependence. It offers a treatment approach for alcohol-dependent individuals with "high-risk drinking levels" to reduce their alcohol consumption. However, the neurobiological mechanism underpinning its effects on alcohol consumption remains to be determined. Using a randomized, double-blind, placebo-controlled, within-subject crossover design we aimed to determine the effect of a single dose of nalmefene on striatal blood oxygen level-dependent (BOLD) signal change during anticipation of monetary reward using the monetary incentive delay task following alcohol challenge...
January 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28214231/mechanisms-of-action-and-structure-activity-relationships-of-cytotoxic-flavokawain-derivatives
#18
Charlotte Thieury, Nicolas Lebouvier, Rémy Le Guével, Yann Barguil, Gaëtan Herbette, Cyril Antheaume, Edouard Hnawia, Yoshinori Asakawa, Mohammed Nour, Thierry Guillaudeux
22 Flavokawain derivatives (FKd) were obtained by one step syntheses in order to conduct a SAR study to understand the structural requirements for optimum and selective cytotoxicity. FKd and natural flavokawains A and B found into kava, a South Pacific traditional beverage, were evaluated against nine cancer and one healthy cell lines. The targeted cell cycle phases as well as the effects on the induction of apoptosis and cell cycle protein levels were investigated. Therapeutic improvements (more activity and selectivity) were achieved with FKd compared to natural flavokawains and notably with the 2',3,4',6'-tetramethoxychalcone (FKd 19)...
February 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28213568/estimated-glomerular-filtration-rate-and-albuminuria-are-associated-with-biomarkers-of-cardiac-injury-in-a-population-based-cohort-study-the-maastricht-study
#19
Remy J H Martens, Dorien M Kimenai, Jeroen P Kooman, Coen D A Stehouwer, Frans E S Tan, Otto Bekers, Pieter C Dagnelie, Carla J H van der Kallen, Abraham A Kroon, Karel M L Leunissen, Frank M van der Sande, Nicolaas C Schaper, Simone J S Sep, Miranda T Schram, Jeroen D van Suijlen, Marja P van Dieijen-Visser, Steven J R Meex, Ronald M A Henry
BACKGROUND: Chronic kidney disease (CKD) is associated with an increased cardiovascular disease mortality risk. It is, however, less clear at what point in the course from normal kidney function to CKD the association with cardiovascular disease appears. Studying the associations of estimated glomerular filtration rate (eGFR) and albuminuria with biomarkers of (subclinical) cardiac injury in a population without substantial CKD may clarify this issue. METHODS: We examined the cross-sectional associations of eGFR and urinary albumin excretion (UAE) with high-sensitivity cardiac troponin (hs-cTn) T, hs-cTnI, and N-terminal probrain natriuretic-peptide (NT-proBNP) in 3103 individuals from a population-based diabetes-enriched cohort study...
February 17, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28213073/le-patient-un-interlocuteur-incontournable
#20
EDITORIAL
Rémi Gagnayre
No abstract text is available yet for this article.
January 2017: Soins; la Revue de Référence Infirmière
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