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https://www.readbyqxmd.com/read/29691405/causes-and-implications-of-the-unforeseen-2016-extreme-yield-loss-in-the-breadbasket-of-france
#1
Tamara Ben-Ari, Julien Boé, Philippe Ciais, Remi Lecerf, Marijn Van der Velde, David Makowski
In 2016, France, one of the leading wheat-producing and wheat-exporting regions in the world suffered its most extreme yield loss in over half a century. Yet, yield forecasting systems failed to anticipate this event. We show that this unprecedented event is a new type of compound extreme with a conjunction of abnormally warm temperatures in late autumn and abnormally wet conditions in the following spring. A binomial logistic regression accounting for fall and spring conditions is able to capture key yield loss events since 1959...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691159/a-cross-sectional-study-of-the-prevalence-of-exercise-induced-hypertension-in-childhood-following-repair-of-coarctation-of-the-aorta
#2
Taryn L Luitingh, Melissa G Y Lee, Bryn Jones, Remi Kowalski, Sofia Weskamp Aguero, Jane Koleff, Diana Zannino, Michael M H Cheung, Yves d'Udekem
BACKGROUND: Exercise-testing may be a more tolerable method of detecting hypertension in children after coarctation repair compared to gold-standard 24-hour ambulatory blood pressure (BP) monitoring (ABPM). This study aims to determine the prevalence of exercise-induced hypertension and end-organ damage in children after coarctation repair, and the effectiveness of exercise-testing compared to 24-hour ABPM in this population. METHODS: Exercise-testing (Bruce protocol), transthoracic echocardiogram, 24-hour ABPM, and pulse wave velocity were performed in 41 patients aged 8 to 18 years with previous coarctation repair...
March 27, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29689589/ten-year-clinical-and-radiological-outcomes-of-100-total-hip-arthroplasty-cases-with-a-modern-cementless-dual-mobility-cup
#3
Loïc Laurendon, Rémi Philippot, Thomas Neri, Bertrand Boyer, Frédéric Farizon
INTRODUCTION: The original cementless Sunfit® dual mobility cup (SERF, Décines, France) exhibited limited osseointegration due to its hydroxyapatite and alumina coating. We hypothesized that replacement of the alumina with plasma-sprayed titanium + hydroxyapatite and improvement of the external geometry (Sunfit TH®) would not increase the risk of aseptic loosening. The primary goal of this study was to determine the survivorship and clinical and radiological outcomes among patients with the Sunfit TH® implant...
April 23, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29689402/intradural-lumbar-migration-of-an-intracranial-neurosurgical-hemostatic-clip-associated-with-lumbosciatic-pain
#4
Mourad Ould-Slimane, Martin Petit, Gaëtan Tesson, Jordane Mouton, Rémi Gauthé
BACKGROUND: Clips implanted during intracranial neurosurgical procedures sometimes migrate intradurally with rare cases of spinal migration. The appearance of radicular symptoms of topography concordant with the position of the foreign body leads to discussion about the optimal therapeutic strategy. CASE DESCRIPTION: We report the case of a 52-year-old woman suffering from L5 radicular pain resistant to medical treatment in the presence of L4L5 lumbar stenosis and a neurosurgical clip migrated to the L5S1 level...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29689193/mechanosensation-dynamically-coordinates-polar-growth-and-cell-wall-assembly-to-promote-cell-survival
#5
Valeria Davì, Hirokazu Tanimoto, Dmitry Ershov, Armin Haupt, Henry De Belly, Rémi Le Borgne, Etienne Couturier, Arezki Boudaoud, Nicolas Minc
How growing cells cope with size expansion while ensuring mechanical integrity is not known. In walled cells, such as those of microbes and plants, growth and viability are both supported by a thin and rigid encasing cell wall (CW). We deciphered the dynamic mechanisms controlling wall surface assembly during cell growth, using a sub-resolution microscopy approach to monitor CW thickness in live rod-shaped fission yeast cells. We found that polar cell growth yielded wall thinning and that thickness negatively influenced growth...
April 23, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29689188/dental-and-maxillofacial-signs-in-aarskog-syndrome-a-review-of-3-siblings-and-the-literature
#6
Arnaud Depeyre, Matthias Schlund, Rémi Gryseleyn, Joel Ferri
PURPOSE: Dagfinn Aarksog first described faciodigitogenital syndrome in 1970. Its inheritance is X linked and autosomally recessive. Currently, the diagnosis of Aarskog-Scott syndrome (ASS) is based on clinical dysmorphologic findings and can be supported by genetic examination. REPORT OF CASES: This report describes 3 brothers already diagnosed with ASS who were referred for examination of oral and maxillofacial malformations associated with ASS. They presented classic features of ASS, such as digital and genital (shawl scrotum) anomalies...
March 29, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29688994/generation-of-immunodeficient-rats-with-rag1-and-il2rg-gene-deletions-and-human-tissue-grafting-models
#7
Séverine Ménoret, Laure-Hélène Ouisse, Laurent Tesson, Frédéric Delbos, Delphine Garnier, Séverine Remy, Claire Usal, Jean-Paul Concordet, Carine Giovannangeli, Vanessa Chenouard, Lucas Brusselle, Emmanuel Merieau, Véronique Nerrière-Daguin, Franck Duteille, Frédérique Bellier-Waast, Alexandre Fraichard, Tuan H Nguyen, Ignacio Anegon
BACKGROUND: Immunodeficient mice are invaluable tools to analyze the long-term effects of potentially immunogenic molecules in the absence of adaptive immune responses. Nevertheless, there are models and experimental situations that would beneficiate of larger immunodeficient recipients. Rats are ideally suited to perform experiments in which larger size is needed and are still a small animal model suitable for rodent facilities. Additionally, rats reproduce certain human diseases better than mice, such as ankylosing spondylitis and Duchenne disease and these disease models would greatly benefit of immunodeficient rats to test different immunogenic treatments...
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688967/the-european-society-of-gynaecological-oncology-european-society-for-radiotherapy-and-oncology-european-society-of-pathology-guidelines-for-the-management-of-patients-with-cervical-cancer
#8
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
BACKGROUND: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer. OBJECTIVE: The European Society of Gynaecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide...
May 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29688339/4-5-years-within-patient-evolution-of-a-colistin-resistant-kpc-producing-klebsiella-pneumoniae-st258
#9
Agnès B Jousset, Rémy A Bonnin, Isabelle Rosinski-Chupin, Delphine Girlich, Gaëlle Cuzon, Nicolas Cabanel, Hélène Frech, Eric Farfour, Laurent Dortet, Philippe Glaser, Thierry Naas
Background: KPC-producing Klebsiella pneumoniae (KPC-Kp) have emerged globally over the last decade as a major nosocomial pathogen that threatens patient's care. These highly resistant bacteria are mostly associated with a single Kp clonal group (CG) CG258, but the reasons for its host and hospital adaptation remain largely unknown. Methods: We analyzed the in vivo evolution of a colistin-resistant KPC-Kp-CG258 strain that contaminated a patient following an endoscopy, and was responsible for a fatal bacteraemia 4...
April 21, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29687919/controlling-motion-artefact-levels-in-mr-images-by-suspending-data-acquisition-during-periods-of-head-motion
#10
Rémi Castella, Lionel Arn, Estelle Dupuis, Martina F Callaghan, Bogdan Draganski, Antoine Lutti
PURPOSE: Head movements are a major source of MRI artefacts. Prospective motion correction techniques significantly improve data quality, but strong motion artefacts may remain in the data. We introduce a framework to suspend data acquisition during periods of head motion over a predefined threshold. METHODS: Data was acquired with prospective motion correction and an external optical tracking system. A predictor of motion impact was introduced that accounts for the amplitude of the signal acquired at the time of the motion...
April 24, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29687714/magnesium-ethoxide-promoted-conversion-of-nitriles-to-amidines-and-its-application-in-5-6-dihydroimidazobenzoxazepine-synthesis
#11
Michael E Dalziel, Julie A Deichert, Diane E Carrera, Danial Beaudry, Chong Han, Haiming Zhang, Remy Angelaud
Magnesium ethoxide has been shown to be a mild, safe, and scalable alternative to trimethylaluminum for the direct addition of amines to aryl nitriles to access cyclic amidines. A variety of electronically diverse oxa-, thia-, and diazepine products were successfully synthesized in moderate to high yields. Further elaboration of these compounds to 5,6-dihydroimidazobenzoxazepines, a privileged class of pharmacologically active heterocycles, highlights the utility of this method.
April 24, 2018: Organic Letters
https://www.readbyqxmd.com/read/29686308/unique-treatment-potential-of-cannabidiol-for-the-prevention-of-relapse-to-drug-use-preclinical-proof-of-principle
#12
Gustavo Gonzalez-Cuevas, Remi Martin-Fardon, Tony M Kerr, David G Stouffer, Loren H Parsons, Dana C Hammell, Stan L Banks, Audra L Stinchcomb, Friedbert Weiss
Cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa, has received attention for therapeutic potential in treating neurologic and psychiatric disorders. Recently, CBD has also been explored for potential in treating drug addiction. Substance use disorders are chronically relapsing conditions and relapse risk persists for multiple reasons including craving induced by drug contexts, susceptibility to stress, elevated anxiety, and impaired impulse control. Here, we evaluated the "anti-relapse" potential of a transdermal CBD preparation in animal models of drug seeking, anxiety and impulsivity...
March 22, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29685969/isoform-selective-hdac1-6-8-inhibitors-with-an-imidazo-ketopiperazine-cap-containing-stereochemical-diversity
#13
Bertrand Lecointre, Remy Narozny, Maria Teresa Borrello, Johanna Senger, Alokta Chakrabarti, Manfred Jung, Martin Marek, Christophe Romier, Jelena Melesina, Wolfgang Sippl, Laurent Bischoff, A Ganesan
A series of hydroxamic acids linked by different lengths to a chiral imidazo-ketopiperazine scaffold were synthesized. The compounds with linker lengths of 6 and 7 carbon atoms were the most potent in histone deacetylase (HDAC) inhibition, and were specific submicromolar inhibitors of the HDAC1, HDAC6 and HDAC8 isoforms. A docking model for the binding mode predicts binding of the hydroxamic acid to the active site zinc cation and additional interactions between the imidazo-ketopiperazine and the enzyme rim...
June 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29683444/high-pressure-high-temperature-deformation-experiment-using-the-new-generation-griggs-type-apparatus
#14
Jacques Précigout, Holger Stünitz, Yves Pinquier, Rémi Champallier, Alexandre Schubnel
In order to address geological processes at great depths, rock deformation should ideally be tested at high pressure (> 0.5 GPa) and high temperature (> 300 °C). However, because of the low stress resolution of current solid-pressure-medium apparatuses, high-resolution measurements are today restricted to low-pressure deformation experiments in the gas-pressure-medium apparatus. A new generation of solid-medium piston-cylinder ("Griggs-type") apparatus is here described. Able to perform high-pressure deformation experiments up to 5 GPa and designed to adapt an internal load cell, such a new apparatus offers the potential to establish a technological basis for high-pressure rheology...
April 3, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29680989/challenging-pre-surgical-localization-of-hyperfunctioning-parathyroid-glands-in-primary-hyperparathyroidism-the-added-value-of-18-f-fluorocholine-pet-ct
#15
Serena Grimaldi, Jacques Young, Peter Kamenicky, Dana Hartl, Marie Terroir, Sophie Leboulleux, Amandine Berdelou, Julien Hadoux, Segolene Hescot, Hervé Remy, Eric Baudin, Martin Schlumberger, Désirée Deandreis
PURPOSE: To evaluate the added value of 18 F-Fluorocholine (18 F-FCH) PET/CT in presurgical imaging of patients with primary hyperparathyroidism (HPT) and challenging localization of the hyper-functioning parathyroid glands. METHODS: We included 27 consecutive patients with primary HPT (19 F; median age: 58 years), with either (i) non-conclusive pre-surgical localization with 99 mTc-sestaMIBI scintigraphy and neck ultrasonography (US), (ii) recurrence of previously operated HPT, or (iii) familiar HPT with a suspicion of multiple gland disease...
April 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29680923/taxonomy-of-the-family-arenaviridae-and-the-order-bunyavirales-update-2018
#16
Piet Maes, Sergey V Alkhovsky, Yīmíng Bào, Martin Beer, Monica Birkhead, Thomas Briese, Michael J Buchmeier, Charles H Calisher, Rémi N Charrel, Il Ryong Choi, Christopher S Clegg, Juan Carlos de la Torre, Eric Delwart, Joseph L DeRisi, Patrick L Di Bello, Francesco Di Serio, Michele Digiaro, Valerian V Dolja, Christian Drosten, Tobiasz Z Druciarek, Jiang Du, Hideki Ebihara, Toufic Elbeaino, Rose C Gergerich, Amethyst N Gillis, Jean-Paul J Gonzalez, Anne-Lise Haenni, Jussi Hepojoki, Udo Hetzel, Thiện Hồ, Ní Hóng, Rakesh K Jain, Petrus Jansen van Vuren, Qi Jin, Miranda Gilda Jonson, Sandra Junglen, Karen E Keller, Alan Kemp, Anja Kipar, Nikola O Kondov, Eugene V Koonin, Richard Kormelink, Yegor Korzyukov, Mart Krupovic, Amy J Lambert, Alma G Laney, Matthew LeBreton, Igor S Lukashevich, Marco Marklewitz, Wanda Markotter, Giovanni P Martelli, Robert R Martin, Nicole Mielke-Ehret, Hans-Peter Mühlbach, Beatriz Navarro, Terry Fei Fan Ng, Márcio Roberto Teixeira Nunes, Gustavo Palacios, Janusz T Pawęska, Clarence J Peters, Alexander Plyusnin, Sheli R Radoshitzky, Víctor Romanowski, Pertteli Salmenperä, Maria S Salvato, Hélène Sanfaçon, Takahide Sasaya, Connie Schmaljohn, Bradley S Schneider, Yukio Shirako, Stuart Siddell, Tarja A Sironen, Mark D Stenglein, Nadia Storm, Harikishan Sudini, Robert B Tesh, Ioannis E Tzanetakis, Mangala Uppala, Olli Vapalahti, Nikos Vasilakis, Peter J Walker, Guópíng Wáng, Lìpíng Wáng, Yànxiăng Wáng, Tàiyún Wèi, Michael R Wiley, Yuri I Wolf, Nathan D Wolfe, Zhìqiáng Wú, Wénxìng Xú, Li Yang, Zuòkūn Yāng, Shyi-Dong Yeh, Yǒng-Zhèn Zhāng, Yàzhōu Zhèng, Xueping Zhou, Chénxī Zhū, Florian Zirkel, Jens H Kuhn
In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. At the same time, the recently established order Bunyavirales was expanded by 3 species. This article presents the updated taxonomy of the family Arenaviridae and the order Bunyavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV) and summarizes additional taxonomic proposals that may affect the order in the near future.
April 21, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29678057/user-profile-detection-in-health-online-fora
#17
Camille Pertin, Carole Deccache, Rémi Gagnayre, Thierry Hamon
Exchanges between diabetic patients on discussion fora permit to study their understanding of their disorder, their behavior and needs when facing health problems. When analyzing these exchanges and behavior, it is necessary to collect information on user profile. We present an approach combining lexicon and super-vised classifiers for the identification of age and gender of contributors, their disorders and relation between contributor and patient. According to parameters of the method, precision is between 100% for gender and 53...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29676907/%C3%AE-glucocerebrosidase-modulators-promote-dimerization-of-%C3%AE-glucocerebrosidase-and-reveal-an-allosteric-binding-site
#18
Jianbin Zheng, Long Chen, Owen S Skinner, Daniel Ysselstein, Jonathan Remis, Peter Lansbury, Renato Skerlj, Michael Mrosek, Ursula Heunisch, Stephan Krapp, Joel Charrow, Michael Schwake, Neil L Kelleher, Richard B Silverman, Dimitri Krainc
β-Glucocerebrosidase (GCase) mutations cause Gaucher's disease and are a high risk factor in Parkinson's disease. The implementation of a small molecule modulator is a strategy to restore proper folding and lysosome delivery of degradation-prone mutant GCase. Here, we present a potent quinazoline modulator, JZ-4109, which stabilizes wild-type and N370S mutant GCase and increases GCase abundance in patient-derived fibroblast cells. We then developed a covalent modification strategy using a lysine targeted inactivator (JZ-5029) for in vitro mechanistic studies...
April 20, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29674338/prevalence-of-hypertension-in-children-with-early-stage-adpkd
#19
Laura Massella, Djalila Mekahli, Dušan Paripović, Larisa Prikhodina, Nathalie Godefroid, Anna Niemirska, Ayşe Ağbaş, Karolina Kalicka, Augustina Jankauskiene, Malgorzata Mizerska-Wasiak, Alberto Caldas Afonso, Rémi Salomon, Georges Deschênes, Gema Ariceta, Z Birsin Özçakar, Ana Teixeira, Ali Duzova, Jérôme Harambat, Tomáš Seeman, Gabriela Hrčková, Adrian Catalin Lungu, Svetlana Papizh, Amira Peco-Antic, Stéphanie De Rechter, Ugo Giordano, Marietta Kirchner, Teresa Lutz, Franz Schaefer, Olivier Devuyst, Elke Wühl, Francesco Emma
BACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease is the most common inheritable kidney disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal dominant polycystic kidney disease may develop signs or symptoms during childhood, in particular hypertension. Although ambulatory BP monitoring is the preferred method to diagnose hypertension in pediatrics, data in children with autosomal dominant polycystic kidney disease are limited...
April 19, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29672724/spatial-variation-in-body-size-and-wing-dimorphism-correlates-with-environmental-conditions-in-the-grasshopper-dichroplus-vittatus-orthoptera-acrididae
#20
Natalia Rosetti, Maria I Remis
Wing dimorphism occurs widely in insects and involves discontinuous variation in a wide variety of traits involved in fight and reproduction. In the current study, we analyzed the spatial pattern of wing dimorphism and intraspecific morphometric variation in nine natural populations of the grasshopper Dichroplus vittatus (Bruner; Orthoptera: Acrididae) in Argentina. Considerable body size differences among populations, between sexes and wing morphs were detected. As a general trend, females were larger than males and macropterous individuals showed increased thorax length over brachypterous which can be explained by the morphological requirements for the development of flight muscles in the thoracic cavity favoring dispersal...
April 17, 2018: Environmental Entomology
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