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https://www.readbyqxmd.com/read/28345997/evaluation-of-a-new-method-to-determine-the-tibial-tuberosity-advancement-distance-required-to-reduce-the-patellar-tendon-tibial-plateau-angle-to-90%C3%A2-with-the-modified-maquet-technique-in-dogs
#1
Paul Pillard, Veronique Livet, Quentin Cabon, Camille Bismuth, Juliette Sonet, Denise Remy, Didier Fau, Claude Carozzo, Eric Viguier, Thibaut Cachon
OBJECTIVE To assess use of a new radiographic method to determine the distance by which the tibial tuberosity should be advanced to reduce the patellar tendon-tibial plateau angle (PTA) to 90° by means of the modified Maquet technique (MMT) in dogs. SAMPLE 24 pelvic limbs from 12 adult medium-sized to large-breed canine cadavers. PROCEDURES Radiographs of stifle joints at 135° extension in true lateral position were used to determine tibial tuberosity advancement distances for use in the MMT. A method was devised to incorporate the planned osteotomy axis; distal patellar translations of 0, 3, 5, or 10 mm; and advancement cage implant application level along the osteotomy site in advancement planning measurements...
April 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28344989/efficient-presentation-of-multiple-endogenous-epitopes-to-both-cd4-and-cd8-diabetogenic-t-cells-for-tolerance
#2
Shamael R Dastagir, Jorge Postigo-Fernandez, Chunliang Xu, James H Stoeckle, Rebuma Firdessa-Fite, Rémi J Creusot
Antigen-specific immunotherapy of type 1 diabetes, typically via delivery of a single native β cell antigen, has had little clinical benefit to date. With increasing evidence that diabetogenic T cells react against multiple β cell antigens, including previously unappreciated neo-antigens that can be emulated by mimotopes, a shift from protein- to epitope-based therapy is warranted. To this end, we aimed to achieve efficient co-presentation of multiple major epitopes targeting both CD4(+) and CD8(+) diabetogenic T cells...
March 17, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28344541/olfm4-kng1-and-sec24c-identified-by-proteomics-and-immunohistochemistry-as-potential-markers-of-early-colorectal-cancer-stages
#3
Florence Quesada-Calvo, Charlotte Massot, Virginie Bertrand, Rémi Longuespée, Noëlla Blétard, Joan Somja, Gabriel Mazzucchelli, Nicolas Smargiasso, Dominique Baiwir, Marie-Claire De Pauw-Gillet, Philippe Delvenne, Michel Malaise, Carla Coimbra Marques, Marc Polus, Edwin De Pauw, Marie-Alice Meuwis, Edouard Louis
BACKGROUND: Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is important for reducing CRC incidence and increasing patient's survival. METHODS: We analysed 76 colorectal tissue samples originated from early CRC stages, normal or inflamed mucosa by label-free proteomics. The characterisation of three selected biomarker candidates was performed by immunohistochemistry on an independent set of precancerous and cancerous lesions harbouring increasing CRC stages...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28344163/characterization-of-antibody-response-in-neuroinvasive-infection-caused-by-toscana-virus
#4
Anna Pierro, Sabrina Ficarelli, Nazli Ayhan, Silvia Morini, Luigi Raumer, Michele Bartoletti, Antonio Mastroianni, Francesca Prati, Simona Schivazappa, Patrizia Cenni, Caterina Vocale, Giada Rossini, Paolo Gaibani, Vittorio Sambri, Maria Paola Landini, Russel Edward Lewis, Remi N Charrel, Stefania Varani
OBJECTIVES: Among sandfly-borne pathogens, Toscana virus (TOSV) is a prominent cause of summer meningitis in Mediterranean Europe. Here, we assessed the kinetics of anti-TOSV antibodies over time in 41 patients diagnosed with TOSV-meningitis or meningoencephalitis in North-eastern Italy. METHODS: Acute and follow-up serum samples were collected up to 20 months after diagnosis of TOSV infection and tested for the presence of specific antibody using immunoenzymatic and indirect immunofluorescence assays...
March 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28342735/inhibition-of-effector-antigen-specific-t-cells-by-intradermal-administration-of-heme-oxygenase-1-inducers
#5
Thomas Simon, Julien Pogu, Séverine Rémy, Frédéric Brau, Sylvie Pogu, Maud Maquigneau, Jean-François Fonteneau, Nicolas Poirier, Bernard Vanhove, Gilles Blancho, Eliane Piaggio, Ignacio Anegon, Philippe Blancou
Developing protocols aimed at inhibiting effector T cells would be key for the treatment of T cell-dependent autoimmune diseases including type 1 autoimmune diabetes (T1D) and multiple sclerosis (MS). While heme oxygenase-1 (HO-1) inducers are clinically approved drugs for non-immune-related diseases, they do have immunosuppressive properties when administered systemically in rodents. Here we show that HO-1 inducers inhibit antigen-specific effector T cells when injected intradermally together with the T cell cognate antigens in mice...
March 22, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28342294/benzylphenylpyrrolizinones-with-anti-amyloid-and-scavenging-effects-potentially-useful-in-alzheimer-s-disease-treatment
#6
Jean-Pierre Gabriel Jourdan, Marc Since, Laîla El Kihel, Cédric Lecoutey, Sophie Corvaisier, Rémi Legay, Jana Sopkova-de Oliveira Santos, Thierry Cresteil, Aurélie Malzert-Fréon, Christophe Rochais, Patrick Dallemagne
This article describes the drug design steps developed to try to increase the scavenging and Aβ aggregation inhibition activities of a previously described series of benzylidenephenyl-pyrrolizinones. Among the novel synthesized derivatives, some benzylphenylpyrrolizinones exhibited interesting results in regard to those activities and first druggability parameters which confer to these compounds a potential therapeutic interest in Alzheimer's disease.
March 25, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28341097/first-report-of-oxa-232-producing-klebsiella-pneumoniae-strains-in-tunisia
#7
Hella Lahlaoui, Rémy A Bonnin, Mohamed Ben Moussa, Anis Ben Haj Khelifa, Thierry Naas
Eleven carbapenem-resistant Klebsiella pneumoniae isolates were recovered from the military hospital of Tunis, Tunisia. Three of these isolates carried the carbapenemase blaOXA-232 gene recently identified in France. These isolates were clonally related and co-expressed the extended-spectrum ß-lactamase, CTX-M-15. This work identified the occurrence of OXA-232 producers in North-African countries.
March 11, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28340612/the-singular-epidemiology-of-hpv-infection-among-french-guianese-women-with-normal-cytology
#8
Antoine Adenis, Valentin Dufit, Maylis Douine, Fatiha Najioullah, Vincent Molinie, Dominique Catherine, Odile Kilié, Nadia Thomas, Jean Luc Deshayes, Paul Brousse, Hatem Ben Amor, Remy Pignoux, Gabriel Carles, Claire Grenier, Vincent Lacoste, Raymond Cesaire, Mathieu Nacher
BACKGROUND: In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana. METHODS: Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear...
March 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28339516/improving-a-full-text-search-engine-the-importance-of-negation-detection-and-family-history-context-to-identify-cases-in-a-biomedical-data-warehouse
#9
Nicolas Garcelon, Antoine Neuraz, Vincent Benoit, Rémi Salomon, Anita Burgun
Objective: The repurposing of electronic health records (EHRs) can improve clinical and genetic research for rare diseases. However, significant information in rare disease EHRs is embedded in the narrative reports, which contain many negated clinical signs and family medical history. This paper presents a method to detect family history and negation in narrative reports and evaluates its impact on selecting populations from a clinical data warehouse (CDW). Materials and Methods: We developed a pipeline to process 1...
October 20, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28338296/photochromism-and-dual-color-fluorescence-in-a-polyoxometalate-benzospiropyran-molecular-switch
#10
Arnaud Parrot, Aurélie Bernard, Aurélie Jacquart, Stefano Artin Serapian, Carles Bo, Etienne Derat, Olivier Oms, Anne Dolbecq, Anna Proust, Rémi Métivier, Pierre Mialane, Guillaume Izzet
The photophysical properties of a Keggin-type polyoxometalate (POM) covalently bounded to a benzospiropyran (BSPR) unit have been investigated. These studies reveal that both closed and open forms are emissive with distinct spectral features (λem (closed form)=530 nm, λem (open form)=670 nm) and that the fluorescence of the BSPR unit of the hybrid is considerably enhanced compared to BSPR parent compounds. While the fluorescence excitation energy of the BSPR reference compounds (370 nm) is close to the intense absorption responsible of the photochromic character (350 nm), the fluorescence excitation of the hybrid is shifted to lower energy (400 nm), improving the population of the emissive state...
March 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28337033/cortical-cells-reveal-app-as-a-new-player-in-the-regulation-of-gabaergic-neurotransmission
#11
Anna Doshina, Florian Gourgue, Michiho Onizuka, Remi Opsomer, Peng Wang, Kunie Ando, Bernadette Tasiaux, Ilse Dewachter, Pascal Kienlen-Campard, Jean-Pierre Brion, Philippe Gailly, Jean-Noël Octave, Nathalie Pierrot
The amyloid precursor protein (APP) modulates synaptic activity, resulting from the fine tuning of excitatory and inhibitory neurotransmission. GABAergic inhibitory neurotransmission is affected by modifications in intracellular chloride concentrations regulated by Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) and neuronal K(+)-Cl(-) cotransporter 2 (KCC2), allowing entrance and efflux of chloride, respectively. Modifications in NKCC1 and KCC2 expression during maturation of cortical cells induce a shift in GABAergic signaling...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28335179/evaluation-of-the-effectiveness-and-the-irradiation-of-pelvic-venous-embolization
#12
Flore Tillie Pansini, Rémi Laurent, Nicolas Delhaye, Ambre Bohnert, Béatrice Sarraz-Bournet, Jacques Chevalier
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28334932/ribosome-dependent-vibrio-cholerae-mrnase-higb2-is-regulated-by-a-%C3%AE-strand-sliding-mechanism
#13
San Hadži, Abel Garcia-Pino, Sarah Haesaerts, Dukas Jurenas, Kenn Gerdes, Jurij Lah, Remy Loris
Toxin-antitoxin (TA) modules are small operons involved in bacterial stress response and persistence. higBA operons form a family of TA modules with an inverted gene organization and a toxin belonging to the RelE/ParE superfamily. Here, we present the crystal structures of chromosomally encoded Vibrio cholerae antitoxin (VcHigA2), toxin (VcHigB2) and their complex, which show significant differences in structure and mechanisms of function compared to the higBA module from plasmid Rts1, the defining member of the family...
February 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334797/molecular-mechanism-governing-ratio-dependent-transcription-regulation-in-the-ccdab-operon
#14
Alexandra Vandervelde, Igor Drobnak, San Hadži, Yann G-J Sterckx, Thomas Welte, Henri De Greve, Daniel Charlier, Rouslan Efremov, Remy Loris, Jurij Lah
Bacteria can become transiently tolerant to several classes of antibiotics. This phenomenon known as persistence is regulated by small genetic elements called toxin-antitoxin modules with intricate yet often poorly understood self-regulatory features. Here, we describe the structures of molecular complexes and interactions that drive the transcription regulation of the ccdAB toxin-antitoxin module. Low specificity and affinity of the antitoxin CcdA2 for individual binding sites on the operator are enhanced by the toxin CcdB2, which bridges the CcdA2 dimers...
February 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334699/robust-cell-tracking-in-epithelial-tissues-through-identification-of-maximum-common-subgraphs
#15
Jochen Kursawe, Rémi Bardenet, Jeremiah J Zartman, Ruth E Baker, Alexander G Fletcher
Tracking of cells in live-imaging microscopy videos of epithelial sheets is a powerful tool for investigating fundamental processes in embryonic development. Characterizing cell growth, proliferation, intercalation and apoptosis in epithelia helps us to understand how morphogenetic processes such as tissue invagination and extension are locally regulated and controlled. Accurate cell tracking requires correctly resolving cells entering or leaving the field of view between frames, cell neighbour exchanges, cell removals and cell divisions...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28333348/promoter-characterization-and-expression-of-the-blakpc-2-gene-in-escherichia-coli-pseudomonas-aeruginosa-and-acinetobacter-baumannii
#16
Delphine Girlich, Rémy A Bonnin, Agnes Jousset, Thierry Naas
Objectives: KPC-producing pathogens exhibit variable carbapenem susceptibility levels, which is probably the result of the genetic environment of the bla KPC genes. Here we determined the transcriptional start sites (TSSs) and the expression of the bla KPC-2 gene in various genetic contexts and in different hosts ( Escherichia coli , Pseudomonas aeruginosa and Acinetobacter baumannii ). Methods: The bla KPC-2 genes along with the upstream sequences derived from Tn 4401b (structure A), Tn 4401b interrupted by Tn 3 /IS 26 (structure B) and Tn 4401b interrupted by Tn 5563 (structure C) were cloned in two E...
March 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28333086/the-effect-of-a-breakfast-rich-in-slowly-digestible-starch-on-glucose-metabolism-a-statistical-meta-analysis-of-randomized-controlled-trials
#17
REVIEW
Sophie Vinoy, Alexandra Meynier, Aurélie Goux, Nathalie Jourdan-Salloum, Sylvie Normand, Rémi Rabasa-Lhoret, Olivier Brack, Julie-Anne Nazare, François Péronnet, Martine Laville
Starch digestibility may have an effect on the postprandial blood glucose profile. The aim of this meta-analysis was to analyze the relationship between Slowly Digestible Starch (SDS) levels and plasma glucose appearance and disappearance rates, as well as other parameters of glucose metabolism, after healthy subjects consumed cereal products that differed in SDS content. Three randomized controlled clinical trials that included a total of 79 subjects were identified. Using binary classification for the variables (high versus low levels, more than 12 g of SDS per portion, and less than 1 g of SDS per portion, respectively), we found that there was a 15-fold higher chance of having a low rate of appearance of exogenous glucose (RaE) after consumption of a high-SDS product...
March 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28332742/computational-neuroscience-in-the-european-journal-of-neuroscience
#18
EDITORIAL
Panayiota Poirazi, Stefan Remy, Athanasia Papoutsi
Many of us played computer games during our childhood and youth, and some of us still do, while others decided to do something seemingly more useful - like trying to better understand the mammalian brain. Many computer games have a linear progression; individual levels are subdivisions of a larger, more complex world. The practical advantage of having levels is that they divide a game into manageable sections. This article is protected by copyright. All rights reserved.
March 23, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28330432/preoperative-ct-scan-based-sizing-and-in-stent-restenosis-in-peripheral-endovascular-revascularizations
#19
Adrien Kaladji, Maximilien Giovannetti, Remy Pascot, Elodie Clochard, Anne Daoudal, Antoine Lucas, Alain Cardon
Objectives This study evaluates the effect of stent sizing with CT-scan on the incidence of restenosis in peripheral arterial disease. Methods This retrospective study included 59 patients with 66 arterial lesions who underwent a endovascular procedure for peripheral arterial disease between April 2013 and October 2013. All patients had de novo iliac or femoral lesions, were candidates for an endovascular procedure alone and underwent CTA preoperatively. The stent actually implanted, whose dimensions were chosen on the basis of the operator's experience on an intraoperative 2D angiography, was compared to the "ideal" stent chosen retrospectively on the basis of precise lesion sizing by the preoperative CTA...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28330064/mise-en-place-des-atlas-des-territoires-vasculaires-c%C3%A3-r%C3%A3-braux%C3%A2-la-zone-jonctionnelle-interne
#20
Sylvain Grange, Fabien Schneider, Rémi Grange, Rémi Richaud, Pierre Garnier, Fabrice-Guy Barral, Claire Boutet
No abstract text is available yet for this article.
March 2017: Journal of Neuroradiology. Journal de Neuroradiologie
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