keyword
https://read.qxmd.com/read/38282203/optical-trapping-and-fast-discrimination-of-label-free-bacteriophages-at-the-single-virion-level
#21
JOURNAL ARTICLE
Nicolas Villa, Enrico Tartari, Simon Glicenstein, Hugues de Villiers de la Noue, Emmanuel Picard, Pierre R Marcoux, Marc Zelsmann, Grégory Resch, Emmanuel Hadji, Romuald Houdré
There is a recent resurgence of interest in phage therapy (the therapeutic use of bacterial viruses) as an approach to eliminating difficult-to-treat infections. However, existing approaches for therapeutic phage selection and virulence testing are time-consuming, host-dependent, and facing reproducibility issues. Here, this study presents an innovative approach wherein integrated resonant photonic crystal (PhC) cavities in silicon are used as optical nanotweezers for probing and manipulating single bacteria and single virions with low optical power...
January 28, 2024: Small
https://read.qxmd.com/read/38261249/how-do-forewarnings-and-post-warnings-affect-misinformation-reliance-the-impact-of-warnings-on-the-continued-influence-effect-and-belief-regression
#22
JOURNAL ARTICLE
Klara Austeja Buczel, Adam Siwiak, Malwina Szpitalak, Romuald Polczyk
People often continue to rely on certain information in their reasoning, even if this information has been retracted; this is called the continued influence effect (CIE) of misinformation. One technique for reducing this effect involves explicitly warning people that there is a possibility that they might have been misled. The present study aimed to investigate these warnings' effectiveness, depending on when they were given (either before or after misinformation). In two experiments (N = 337), we found that while a forewarning did reduce reliance on misinformation, retrospectively warned participants (when the warning was placed either between the misinformation and the retraction or just before testing) relied on the misinformation to a similar degree as unwarned participants...
January 23, 2024: Memory & Cognition
https://read.qxmd.com/read/38255217/brain-plasticity-modulator-p75-neurotrophin-receptor-in-human-urine-after-different-acute-brain-injuries-a-prospective-cohort-study
#23
JOURNAL ARTICLE
Santtu Hellström, Antti Sajanti, Abhinav Srinath, Carolyn Bennett, Romuald Girard, Ying Cao, Janek Frantzén, Fredrika Koskimäki, Johannes Falter, Seán B Lyne, Tomi Rantamäki, Riikka Takala, Jussi P Posti, Susanna Roine, Jukka Puolitaival, Miro Jänkälä, Sulo Kolehmainen, Melissa Rahi, Jaakko Rinne, Eero Castrén, Janne Koskimäki
Acute brain injuries (ABIs) pose a substantial global burden, demanding effective prognostic indicators for outcomes. This study explores the potential of urinary p75 neurotrophin receptor (p75NTR) concentration as a prognostic biomarker, particularly in relation to unfavorable outcomes. The study involved 46 ABI patients, comprising sub-cohorts of aneurysmal subarachnoid hemorrhage, ischemic stroke, and traumatic brain injury. Furthermore, we had four healthy controls. Samples were systematically collected from patients treated at the University Hospital of Turku between 2017 and 2019, at early (1...
January 5, 2024: Biomedicines
https://read.qxmd.com/read/38195510/transcriptomic-signatures-of-individual-cell-types-in-cerebral-cavernous-malformation
#24
JOURNAL ARTICLE
Ying Li, Romuald Girard, Abhinav Srinath, Diana Vera Cruz, Cezary Ciszewski, Chang Chen, Rhonda Lightle, Sharbel Romanos, Je Yeong Sone, Thomas Moore, Dorothy DeBiasse, Agnieszka Stadnik, Justine J Lee, Robert Shenkar, Janne Koskimäki, Miguel A Lopez-Ramirez, Douglas A Marchuk, Mark H Ginsberg, Mark L Kahn, Changbin Shi, Issam A Awad
Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that different cell types may play a role in CCM pathogenesis. The contribution of each cell type to the dysfunctional cellular crosstalk remains unclear. Herein, RNA-seq was performed on fluorescence-activated cell sorted endothelial cells (ECs), pericytes, and neuroglia from CCM lesions and non-lesional brain tissue controls. Differentially Expressed Gene (DEG), pathway and Ligand-Receptor (LR) analyses were performed to characterize the dysfunctional genes of respective cell types within CCMs...
January 9, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38185368/cadaveric-study-of-flexor-digitorum-profundus-and-superficialis-and-flexor-pollicis-longus-innervation-patterns-for-application-in-selective-neurectomy
#25
JOURNAL ARTICLE
Gautier Houziaux, Romuald Seizeur, Weiguo Hu, Alexandra Forli, Anne Perruisseau-Carrier
PURPOSE: Spasticity management in finger flexors (flexor digitorum profundus and superficialis and flexor pollicis longus) is a challenge. Recent studies demonstrated the short- and long-term efficacy of selective and hyperselective neurectomy for the spastic upper limb. However, hyperselective neurectomy of flexor digitorum profundus and flexor digitorum superficialis branches was incomplete, without impairing their muscular body and function. This cadaveric study describes a novel medial approach in the forearm, to reach all the muscular branches: flexor digitorum superficialis and profundus and flexor pollicis longus...
January 5, 2024: Hand Surgery and Rehabilitation
https://read.qxmd.com/read/38181211/cadence-modulation-during-eccentric-cycling-affects-perception-of-effort-but-not-neuromuscular-alterations
#26
JOURNAL ARTICLE
Adrien Mater, Adrien Boly, Alain Martin, Romuald Lepers
INTRODUCTION: A recent study showed that cadence modulation during short eccentric (ECC) cycling exercise affects oxygen consumption (VO2), muscular activity (EMG), and perception of effort (PE). This study examined the effect of cadence on VO2, EMG and PE during prolonged ECC cycling and exercise-induced neuromuscular alterations. METHODS: 22 participants completed three sessions 2-3 weeks apart: 1) determination of the maximal concentric peak power output (PPO), familiarization with eccentric cycling at two cadences (30 and 60 rpm at 60%PPO) and neuromuscular testing procedure; 2) and 3) 30 min of eccentric cycling exercise at a cadence of 30 or 60 rpm...
December 27, 2023: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/38155267/acute-smartphone-use-impairs-vigilance-and-inhibition-capacities
#27
JOURNAL ARTICLE
Thomas Jacquet, Romuald Lepers, Benjamin Pageaux, Bénédicte Poulin-Charronnat
Smartphones are now in very widespread use, and concerns have arisen about potential detrimental effects, even with acute use. These adverse consequences are often linked to the emergence of mental fatigue. While the cognitive implications of fatigue are well-documented, knowledge about the specific influence of acute smartphone use on cognitive performance remains scarce. The aim of this study was therefore to investigate the impact of acute smartphone use on cognitive performance. It included two experiments: one designed to assess the impact of smartphone use on vigilance, and the other focusing on evaluating inhibition capacities...
December 27, 2023: Scientific Reports
https://read.qxmd.com/read/38153083/effects-of-2-4-ghz-radiofrequency-electromagnetic-field-rf-emf-on-glioblastoma-cells-u-118-mg
#28
JOURNAL ARTICLE
Agnieszka Nowak-Terpiłowska, Romuald Górski, Małgorzata Marszałek, Stanisław Wosiński, Rafał Przesmycki, Marek Bugaj, Leszek Nowosielski, Mikołaj Baranowski, Joanna Zeyland
INTRODUCTION AND OBJECTIVE: Mobile phones and Wi-Fi are the most commonly used forms of telecommunications. Initiated with the first generation, the mobile telephony is currently in its fifth generation without being screened extensively for any biological effects that it may have on humans or on animals. Some studies indicate that high frequency electromagnetic radiation emitted by mobile phone and Wi-Fi connection can have a negative effect upon human health, and can cause cancer, including brain tumour...
December 22, 2023: Annals of Agricultural and Environmental Medicine: AAEM
https://read.qxmd.com/read/38142836/extracellular-nucleotides-in-smooth-muscle-contraction
#29
REVIEW
Romuald Brice Babou Kammoe, Jean Sévigny
Extracellular nucleotides and nucleosides are crucial signalling molecules, eliciting diverse biological responses in almost all organs and tissues. These molecules exert their effects by activating specific nucleotide receptors, which are finely regulated by ectonucleotidases that break down their ligands. In this comprehensive review, we aim to elucidate the relevance of extracellular nucleotides as signalling molecules in the context of smooth muscle contraction, considering the modulatory influence of ectonucleotidases on this intricate process...
December 22, 2023: Biochemical Pharmacology
https://read.qxmd.com/read/38136652/ethnobotany-phytochemistry-and-biological-activities-of-the-genus-cordyline
#30
REVIEW
Romuald Tematio Fouedjou, Bienvenu Tsakem, Xavier Siwe-Noundou, Hervet P Dongmo Fogang, Aphalaine Tiombou Donkia, Beaudelaire Kemvoufo Ponou, Madan Poka, Patrick H Demana, Rémy B Teponno, Léon Azefack Tapondjou
Cordyline species have a long history in traditional medicine as a basis of treatment for various ailments such as a bloody cough, dysentery, and a high fever. There are about 26 accepted species names in this genus distributed worldwide, including C. fruticosa , C. autralis , C. stricta , C. cannifolia , and C. dracaenosides . This work presents a comprehensive review of the traditional uses of plants of the genus Cordylie and their chemical constituents and biological activities. A bibliographic search was conducted to identify available information on ethnobotany, ethnopharmacology, chemical composition, and biological activities...
December 12, 2023: Biomolecules
https://read.qxmd.com/read/38134268/trial-readiness-of-cavernous-malformations-with-symptomatic-hemorrhage-part-i-event-rates-and-clinical-outcome
#31
JOURNAL ARTICLE
Kelly D Flemming, Helen Kim, Stephanie Hage, Jay Mandrekar, Serena Kinkade, Romuald Girard, Michel Torbey, Judy Huang, John Huston, Yunhong Shu, Giuseppe Lanzino, Reed Selwyn, Blaine Hart, Marc Mabray, James Feghali, Haris I Sair, Jared Narvid, Janine M Lupo, Justine Lee, Agnieszka Stadnik, Roberto J Alcazar-Felix, Robert Shenkar, Karen Lane, Nichole McBee, Kevin Treine, Noeleen Ostapkovich, Ying Wang, Richard Thompson, James I Koenig, Timothy Carroll, Daniel Hanley, Issam Awad
BACKGROUND: Cerebral cavernous malformation with symptomatic hemorrhage (SH) are targets for novel therapies. A multisite trial-readiness project (https://www.clinicaltrials.gov; Unique identifier: NCT03652181) aimed to identify clinical, imaging, and functional changes in these patients. METHODS: We enrolled adult cerebral cavernous malformation patients from 5 high-volume centers with SH within the prior year and no planned surgery. In addition to clinical and imaging review, we assessed baseline, 1- and 2-year National Institutes of Health Stroke Scale, modified Rankin Scale, European Quality of Life 5D-3 L, and patient-reported outcome-measurement information system, Version 2...
January 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38134265/trial-readiness-of-cavernous-malformations-with-symptomatic-hemorrhage-part-ii-biomarkers-and-trial-modeling
#32
JOURNAL ARTICLE
Stephanie Hage, Serena Kinkade, Romuald Girard, Kelly D Flemming, Helen Kim, Michel T Torbey, Judy Huang, John Huston, Yunhong Shu, Reed G Selwyn, Blaine L Hart, Marc C Mabray, James Feghali, Haris I Sair, Jared Narvid, Janine M Lupo, Justine Lee, Agnieszka Stadnik, Roberto J Alcazar-Felix, Robert Shenkar, Nicholas Hobson, Dorothy DeBiasse, Karen Lane, Nichole A McBee, Kevin Treine, Noeleen Ostapkovich, Ying Wang, Richard E Thompson, James I Koenig, Timothy Carroll, Daniel F Hanley, Issam A Awad
BACKGROUND: Quantitative susceptibility mapping (QSM) and dynamic contrast-enhanced quantitative perfusion (DCEQP) magnetic resonance imaging sequences assessing iron deposition and vascular permeability were previously correlated with new hemorrhage in cerebral cavernous malformations. We assessed their prospective changes in a multisite trial-readiness project. METHODS: Patients with cavernous malformation and symptomatic hemorrhage (SH) in the prior year, without prior or planned lesion resection or irradiation were enrolled...
January 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38129880/vectorial-competence-insecticide-resistance-in-anopheles-funestus-and-operational-implications-for-malaria-vector-control-strategies-in-benin-republic
#33
REVIEW
Romaric Akoton, Pierre Marie Sovegnon, Oswald Y Djihinto, Adandé A Medjigbodo, Romuald Agonhossou, Helga M Saizonou, Genevieve M Tchigossou, Seun M Atoyebi, Eric Tossou, Francis Zeukeng, Hamirath O Lagnika, Wassiyath Mousse, Ayola Akim Adegnika, Rousseau Djouaka, Luc S Djogbénou
The primary reason for the failure of malaria vector control across endemic regions is the widespread insecticide resistance observed in Anopheles vectors. The most dominant African vectors of malaria parasites are Anopheles gambiae and Anopheles funestus mosquitoes. These species often exhibit divergent behaviours and adaptive changes underscoring the importance of deploying active and effective measures in their control. Unlike An. gambiae, An. funestus mosquitoes are poorly studied in Benin Republic. However, recent reports indicated that An...
December 21, 2023: Malaria Journal
https://read.qxmd.com/read/38111246/cutaneous-larva-migrans-as-a-frequent-problem-in-travellers
#34
JOURNAL ARTICLE
Anna Kuna, Romuald Olszański, Katarzyna Sikorska
Dermatological disorders are among the most common complaints of patients seeking medical assistance after returning from trips to tropical countries. Among exotic dermatoses, one of the frequently encountered diagnoses is Cutaneous Larva Migrans (CLM), primarily caused by the nematodes Ancylostoma braziliense and A. caninum. Cats and dogs, which serve as the definitive hosts for these nematodes, excrete with their stool parasite eggs into the environment, where they transform into larvae. Human infection occurs through the invasive form of the larvae, which penetrate the skin, causing itching and the characteristic serpiginous, slightly raised, and enlarging lesion at the site of invasion...
2023: International Maritime Health
https://read.qxmd.com/read/38105801/outcome-and-survival-of-surgically-treated-acute-subdural-hematomas-and-postcraniotomy-hematomas-a-retrospective-cohort-study
#35
JOURNAL ARTICLE
Iiro Heino, Antti Sajanti, Seán B Lyne, Janek Frantzén, Romuald Girard, Ying Cao, Joel F Ritala, Ari J Katila, Riikka S K Takala, Jussi P Posti, Antti J Saarinen, Santtu Hellström, Dan Laukka, Ilkka Saarenpää, Melissa Rahi, Olli Tenovuo, Jaakko Rinne, Janne Koskimäki
BACKGROUND: The morbidity and mortality of acute subdural hematoma (aSDH) remains high. Several factors have been reported to affect the outcome and survival of these patients. In this study, we explored factors potentially associated with the outcome and survival of surgically treated acute subdural hematoma (aSDH), including postcraniotomy hematomas (PCHs). METHODS: This retrospective cohort study was conducted in a single tertiary university hospital between 2008 and 2012 and all aSDH patients that underwent surgical intervention were included...
2023: Brain Spine
https://read.qxmd.com/read/38104339/-polish-adaptation-and-validation-of-the-individual-work-performance-questionnaire-iwpq
#36
JOURNAL ARTICLE
Arkadiusz Mirosław Jasiński, Romuald Derbis, Linda Koopmans
BACKGROUND: The objective of this study was to test the psychometric properties of the Polish version of the Individual Work Performance Questionnaire (IWPQ). MATERIAL AND METHODS: The study was conducted on 3 independent samples of 1582, 581 and 40 individuals employed as manual workers, social service and white collar workers. To test the IWPQ structure an exploratory factor analysis was conducted. Multigroup confirmatory factor analysis and invariance test were carried out among subgroups...
December 15, 2023: Medycyna Pracy
https://read.qxmd.com/read/38094483/-oculo-orbital-tumours-at-the-national-university-hospital-centre-of-bangui-cnhub-central-african-republic-in-2022
#37
JOURNAL ARTICLE
Rodrigue Romuald Elien Gagnan Yan Zaou Tou, Jean Michel Mbaïkoua, Jess Elio Kosh Komba Palet, Nouhoum Guirou
INTRODUCTION: Oculo-orbital tumors are common. Their clinical and histological features are multiple. The management of oculo-orbital tumors is a real challenge in sub-Saharan Africa, especially in our context. The aim of this study was to contribute to the improvement of the management of oculo-orbital tumors at the Bangui Teaching Hospital (CNHUB). METHODOLOGY: This was a prospective, observational study of oculo-orbital tumors over 12 months from January 1 to December 31, 2022 in the ophthalmology department of the CNHUB...
September 30, 2023: Med Trop Sante Int
https://read.qxmd.com/read/38094189/bone-health-in-children-with-severe-cerebral-palsy
#38
JOURNAL ARTICLE
Vincent Barbier, Vincent Goeb, Richard Gouron, Severine Fritot, Romuald Mentaverri, Céline Klein
AIM: To describe bone health and associated factors in children with severe cerebral palsy. METHOD: In a retrospective, single-centre study, we performed a comprehensive bone evaluation (including clinical, densitometric and bone biomarker assessments) of children with severe cerebral palsy. RESULTS: None of the 19 included children had a normal BMCTBLH Z score, and only one had a BMDTBLH Z score greater than -2. Six children had a BMDLS Z score greater than -2...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/38091334/what-works-in-engaging-communities-prioritising-nutrition-interventions-in-burkina-faso-ghana-and-south-africa
#39
JOURNAL ARTICLE
Daniella Watson, Mary Barker, P Romuald Boua, Samuel Chatio, Adelaide Compaoré, Marion Danis, Maxwell Dalaba, Agnes Erzse, Polly Hardy-Johnson, Sarah H Kehoe, Karen J Hofman, Wendy T Lawrence, Engelbert A Nonterah, Hermann Sorgho, Teurai Rwafa-Ponela, Kate A Ward
BACKGROUND: "Choosing All Together" (CHAT), is a community engagement tool designed to give the public a voice in how best to allocate limited resources to improve population health. This process evaluation explored the mechanisms through which CHAT generates community engagement. METHOD: The CHAT tool was adapted and implemented for use in two rural communities (Nanoro, Burkina Faso, and Navrongo, Ghana) and one urban township (Soweto, South Africa) to prioritize maternal and child nutrition interventions...
2023: PloS One
https://read.qxmd.com/read/38086319/multifactorial-stress-reactivity-to-virtual-tsst-c-in-healthy-children-and-adolescents-it-works-but-not-as-well-as-a-real-tsst-c
#40
JOURNAL ARTICLE
Angelika Ecker, Irina Jarvers, Martin Kocur, Stephanie Kandsperger, Romuald Brunner, Daniel Schleicher
A virtual version of the Trier Social Stress Test (TSST) has been increasingly used in stress research. Benefits of the virtual TSST include that it is more economical, and offers improved control of context and enhanced flexibility of use. Many studies have confirmed the applicability of virtual TSSTs in stress research, but only in adulthood. In the present study, we aimed to experimentally verify the transferability of a virtual TSST to adolescence. A total of 73 healthy adolescents (aged 11-17 years) of both sexes completed either a real (IV-TSST-C) or virtual (VR-TSST-C) TSST for children...
November 24, 2023: Psychoneuroendocrinology
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