Kelly D Flemming, Helen Kim, Stephanie Hage, Jay Mandrekar, Serena Kinkade, Romuald Girard, Michel Torbey, Judy Huang, John Huston, Yunhong Shu, Giuseppe Lanzino, Reed Selwyn, Blaine Hart, Marc Mabray, James Feghali, Haris I Sair, Jared Narvid, Janine M Lupo, Justine Lee, Agnieszka Stadnik, Roberto J Alcazar-Felix, Robert Shenkar, Karen Lane, Nichole McBee, Kevin Treine, Noeleen Ostapkovich, Ying Wang, Richard Thompson, James I Koenig, Timothy Carroll, Daniel Hanley, Issam Awad
BACKGROUND: Cerebral cavernous malformation with symptomatic hemorrhage (SH) are targets for novel therapies. A multisite trial-readiness project (https://www.clinicaltrials.gov; Unique identifier: NCT03652181) aimed to identify clinical, imaging, and functional changes in these patients. METHODS: We enrolled adult cerebral cavernous malformation patients from 5 high-volume centers with SH within the prior year and no planned surgery. In addition to clinical and imaging review, we assessed baseline, 1- and 2-year National Institutes of Health Stroke Scale, modified Rankin Scale, European Quality of Life 5D-3 L, and patient-reported outcome-measurement information system, Version 2...
January 2024: Stroke; a Journal of Cerebral Circulation